[ { "uniprot_canonical_ac": "D0PRN4-1", "uniprot_id": [ { "id": "NRX3B_CHICK", "url": "https://www.uniprot.org/uniprot/D0PRN4", "type": "external" } ], "mass": 72893.0, "length": 668, "protein_name": "Neurexin-3-beta", "gene_name": "NRXN3", "organism": "Chicken", "refseq_name": "neurexin 3 isoform b precursor", "refseq_ac": [ { "id": "NP_001258853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258853", "type": "external" } ], "gene_names_uniprotkb": "NRXN3", "gene_names_refseq": "NRXN3; Neurexin-3", "protein_names_uniprotkb": "Neurexin-3-beta; Neurexin III-beta", "protein_names_refseq": "neurexin 3 isoform b precursor; neurexin III", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "19926856", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EU702430.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000215.1. Transcript Variant: This variant (2) differs in the 5' UTR and lacks multiple exons in the 5' coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (b, also known as beta) is shorter and has a distinct N-terminus, compared to isoform a., [RefSeq]; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion (By similarity). Plays a role in angiogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D0PRN5", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "D0PRN4-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BRE2-1", "uniprot_id": [ { "id": "SIR5_CHICK", "url": "https://www.uniprot.org/uniprot/E1BRE2", "type": "external" } ], "mass": 33956.0, "length": 309, "protein_name": "NAD-dependent protein deacylase sirtuin-5, mitochondrial", "gene_name": "SIRT5", "organism": "Chicken", "refseq_name": "NAD-dependent protein deacylase sirtuin-5, mitochondrial", "refseq_ac": [ { "id": "NP_001263293", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263293", "type": "external" } ], "gene_names_uniprotkb": "SIRT5", "gene_names_refseq": "SIRT5", "protein_names_uniprotkb": "NAD-dependent protein deacylase sirtuin-5, mitochondrial; 2.3.1.-; Regulatory protein SIR2 homolog 5", "protein_names_refseq": "NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial; NAD-dependent protein deacetyalse sirtuin-5; NAD-dependent protein deacylase sirtuin-5, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (gga:420834)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15592404", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX933404.1, SRR13267649.76685.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000040.1. On Feb 3, 2013 this sequence version replaced XP_418925.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the functional protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.7.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.14", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" } ], "go_molecular_function": "GO:0036054 protein-malonyllysine demalonylase activity;GO:0036055 protein-succinyllysine desuccinylase activity;GO:0061697 protein-glutaryllysine deglutarylase activity;GO:0008270 zinc ion binding;GO:0070403 NAD+ binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0010566 regulation of ketone biosynthetic process;GO:0036047 peptidyl-lysine demalonylation;GO:0036048 protein desuccinylation;GO:0036049 peptidyl-lysine desuccinylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BRE2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BSI4-1", "uniprot_id": [ { "id": "E1BSI4_CHICK", "url": "https://www.uniprot.org/uniprot/E1BSI4", "type": "external" } ], "mass": 24602.0, "length": 219, "protein_name": "Charged multivesicular body protein 5", "gene_name": "CHMP5", "organism": "Chicken", "refseq_name": "charged multivesicular body protein 5", "refseq_ac": [ { "id": "NP_001264328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264328", "type": "external" } ], "gene_names_uniprotkb": "CHMP5", "gene_names_refseq": "CHMP5", "protein_names_uniprotkb": "Charged multivesicular body protein 5; Chromatin-modifying protein 5", "protein_names_refseq": "charged multivesicular body protein 5; chromatin modifying protein 5", "tax_id": 9031, "disease": "", "pathway": " (gga:420968); (R-GGA-917729)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01022782.1, HAEL01007092.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000041.1. On Apr 6, 2013 this sequence version replaced XP_419052.2. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005828 kinetochore microtubule;GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0010824 regulation of centrosome duplication;GO:0031468 nuclear membrane reassembly;GO:0039702 viral budding via host ESCRT complex;GO:0097352 autophagosome maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BSI4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BTE1-1", "uniprot_id": [ { "id": "WEE2_CHICK", "url": "https://www.uniprot.org/uniprot/E1BTE1", "type": "external" } ], "mass": 63301.0, "length": 565, "protein_name": "Wee1-like protein kinase 2", "gene_name": "WEE2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "WEE2; WEE1B", "gene_names_refseq": "", "protein_names_uniprotkb": "Wee1-like protein kinase 2; 2.7.10.2; Wee1-like protein kinase 1B; Wee1B kinase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15592404", "class_list": "", "function": "Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051321 meiotic cell cycle;GO:0060631 regulation of meiosis I", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BTE1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BVD1-1", "uniprot_id": [ { "id": "E1BVD1_CHICK", "url": "https://www.uniprot.org/uniprot/E1BVD1", "type": "external" } ], "mass": 35663.0, "length": 314, "protein_name": "aldose reductase", "gene_name": "LOC418170", "organism": "Chicken", "refseq_name": "aldo-keto reductase family 1 member B1", "refseq_ac": [ { "id": "XP_015141727", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015141727", "type": "external" } ], "gene_names_uniprotkb": "LOC418170", "gene_names_refseq": "LOC418170", "protein_names_uniprotkb": "aldose reductase; 1.1.1.21; Aldehyde reductase", "protein_names_refseq": "aldo-keto reductase family 1 member B1", "tax_id": 9031, "disease": "", "pathway": " (gga:418170); (R-GGA-193144); (R-GGA-70221); (R-GGA-975634)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0004032 aldose reductase (NADPH) activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BVD1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BYA3-1", "uniprot_id": [ { "id": "PTSS2_CHICK", "url": "https://www.uniprot.org/uniprot/E1BYA3", "type": "external" } ], "mass": 52146.0, "length": 442, "protein_name": "Phosphatidylserine synthase 2", "gene_name": "PTDSS1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTDSS1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylserine synthase 2; 2.7.8.29; PSS-2; PtdSer synthase 2; Serine-exchange enzyme II", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15592404", "class_list": "", "function": "Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (By similarity). Catalyzes the conversion of phosphatatidylethanolamine and does not act on phosphatidylcholine (By similarity). Can utilize both phosphatidylethanolamine (PE) plasmalogen and diacyl PE as substrate and the latter is six times better utilized, indicating the importance of an ester linkage at the sn-1 position (By similarity). Although it shows no sn-1 fatty acyl preference, exhibits significant preference towards docosahexaenoic acid (22:6n-3) compared with 18:1 or 20:4 at the sn-2 position (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.29", "type": "external" } ], "go_molecular_function": "GO:0106245 L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006659 phosphatidylserine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BYA3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BYJ2-1", "uniprot_id": [ { "id": "MSH6_CHICK", "url": "https://www.uniprot.org/uniprot/E1BYJ2", "type": "external" } ], "mass": 149891.0, "length": 1337, "protein_name": "DNA mismatch repair protein Msh6", "gene_name": "MSH6", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MSH6", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA mismatch repair protein Msh6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15592404;23314153", "class_list": "", "function": "Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity", "go_cellular_component": "GO:0032301 MutSalpha complex;GO:0005634 nucleus", "go_biological_process": "GO:0030890 positive regulation of B cell proliferation;GO:0006298 mismatch repair;GO:0007095 mitotic G2 DNA damage checkpoint signaling;GO:0032876 negative regulation of DNA endoreduplication", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E1BYJ2-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BZ22-1", "uniprot_id": [ { "id": "E1BZ22_CHICK", "url": "https://www.uniprot.org/uniprot/E1BZ22", "type": "external" } ], "mass": 32936.0, "length": 301, "protein_name": "11-beta-hydroxysteroid dehydrogenase 1", "gene_name": "HSD11B1B", "organism": "Chicken", "refseq_name": "corticosteroid 11-beta-dehydrogenase isozyme 1", "refseq_ac": [ { "id": "XP_417988", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_417988", "type": "external" } ], "gene_names_uniprotkb": "HSD11B1B", "gene_names_refseq": "HSD11B1B", "protein_names_uniprotkb": "11-beta-hydroxysteroid dehydrogenase 1; 1.1.1.146; 1.1.1.201; 7-oxosteroid reductase; Corticosteroid 11-beta-dehydrogenase isozyme 1", "protein_names_refseq": "corticosteroid 11-beta-dehydrogenase isozyme 1", "tax_id": 9031, "disease": "", "pathway": " (gga:419861)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052557.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_417988.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.146", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.146", "type": "external" }, { "id": "1.1.1.201", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.201", "type": "external" } ], "go_molecular_function": "GO:0070524 11-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0005496 steroid binding;GO:0047022 7-beta-hydroxysteroid dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006706 steroid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BZ22-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BZW7-1", "uniprot_id": [ { "id": "E1BZW7_CHICK", "url": "https://www.uniprot.org/uniprot/E1BZW7", "type": "external" } ], "mass": 21650.0, "length": 194, "protein_name": "Fibroblast growth factor", "gene_name": "FGF4", "organism": "Chicken", "refseq_name": "fibroblast growth factor 4 precursor", "refseq_ac": [ { "id": "NP_001026717", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026717", "type": "external" } ], "gene_names_uniprotkb": "FGF4", "gene_names_refseq": "FGF4", "protein_names_uniprotkb": "Fibroblast growth factor; FGF", "protein_names_refseq": "FGF-4; HBGF-4; fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene); fibroblast growth factor 4 precursor; heparin-binding growth factor 4", "tax_id": 9031, "disease": "", "pathway": " (gga:428857); (R-GGA-109704); (R-GGA-1257604); (R-GGA-190322); (R-GGA-190372); (R-GGA-190373); (R-GGA-190375); (R-GGA-5654219); (R-GGA-5654221); (R-GGA-5654227); (R-GGA-5654228); (R-GGA-5654687); (R-GGA-5654688); (R-GGA-5654689); (R-GGA-5654693); (R-GGA-5654695); (R-GGA-5654699); (R-GGA-5654700); (R-GGA-5654704); (R-GGA-5654706); (R-GGA-5654710); (R-GGA-5654712); (R-GGA-5654719); (R-GGA-5654720); (R-GGA-5654726); (R-GGA-5654727); (R-GGA-5654732); (R-GGA-5654733); (R-GGA-5658623); (R-GGA-5673001); (R-GGA-6811558)", "pathway_count": 31, "publication_count": 5, "publication_id_list": "16326079;16425226;17326134;17433109;19516907", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888540.226367.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992437 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1. On Nov 18, 2021 this sequence version replaced NP_001026717.2., [RefSeq]; FGF4 treatment increased phosphorylated MAPK (dpERK) signaling and promoted expression of scleraxis and tenascin in embryonic valves., [RefSeq, PubMed]; FGF4-mediated signaling is required for establishing gut tube domains along the A-P axis, [RefSeq, PubMed]; NOGO-A is up-regulated by FGF4 during brain development. Publication Status: Online-Only, [RefSeq, PubMed]; Role of FGF4 in cavitation was shown., [RefSeq, PubMed]; The RA pathway acts synergistically with FGF4 in endoderm patterning rather than mediating FGF4 activity Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0051781 positive regulation of cell division;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "E1BZW7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1C231-1", "uniprot_id": [ { "id": "LTN1_CHICK", "url": "https://www.uniprot.org/uniprot/E1C231", "type": "external" } ], "mass": 199446.0, "length": 1766, "protein_name": "E3 ubiquitin-protein ligase listerin", "gene_name": "LTN1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LTN1; RNF160", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase listerin; 2.3.2.27; RING finger protein 160; RING-type E3 ubiquitin transferase listerin; Zfp-294", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15592404", "class_list": "", "function": "E3 ubiquitin-protein ligase component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains (By similarity). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0043023 ribosomal large subunit binding", "go_cellular_component": "GO:0005829 cytosol;GO:1990112 RQC complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0016567 protein ubiquitination;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1C231-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1C251-1", "uniprot_id": [ { "id": "E1C251_CHICK", "url": "https://www.uniprot.org/uniprot/E1C251", "type": "external" } ], "mass": 10526.0, "length": 92, "protein_name": "Protein S100-B", "gene_name": "S100B", "organism": "Chicken", "refseq_name": "protein S100-B", "refseq_ac": [ { "id": "NP_001289071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289071", "type": "external" } ], "gene_names_uniprotkb": "S100B", "gene_names_refseq": "S100B", "protein_names_uniprotkb": "Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B", "protein_names_refseq": "S100 calcium binding protein, beta (neural); S100 calcium-binding protein, beta; protein S100-B", "tax_id": 9031, "disease": "", "pathway": " (gga:424038); (R-GGA-879415)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX932146.2, CN210870.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX932146.2, CN210870.1 and BU286075.1. On Oct 2, 2014 this sequence version replaced XP_004942606.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0097490 sympathetic neuron projection extension;GO:0007155 cell adhesion;GO:0007611 learning or memory;GO:0008284 positive regulation of cell population proliferation;GO:0045666 positive regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1C251-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1C2E5-1", "uniprot_id": [ { "id": "E1C2E5_CHICK", "url": "https://www.uniprot.org/uniprot/E1C2E5", "type": "external" } ], "mass": 52184.0, "length": 465, "protein_name": "NAD-capped RNA hydrolase NUDT12", "gene_name": "NUDT12", "organism": "Chicken", "refseq_name": "NAD-capped RNA hydrolase NUDT12", "refseq_ac": [ { "id": "XP_001231287", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001231287", "type": "external" } ], "gene_names_uniprotkb": "NUDT12", "gene_names_refseq": "NUDT12", "protein_names_uniprotkb": "NAD-capped RNA hydrolase NUDT12; 3.6.1.22; NADH pyrophosphatase NUDT12; Nucleoside diphosphate-linked moiety X motif 12", "protein_names_refseq": "NAD-capped RNA hydrolase NUDT12", "tax_id": 9031, "disease": "", "pathway": " (gga:768471); (R-GGA-196807)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress. Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle. Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.22", "type": "external" }, { "id": "2.7.7.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.2", "type": "external" }, { "id": "3.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.18", "type": "external" } ], "go_molecular_function": "GO:0000210 NAD+ diphosphatase activity;GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding;GO:0035529 NADH pyrophosphatase activity;GO:1990174 phosphodiesterase decapping endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005777 peroxisome", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0006402 mRNA catabolic process;GO:0032922 circadian regulation of gene expression;GO:0006742 NADP+ catabolic process;GO:0110155 NAD-cap decapping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1C2E5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1C2U2-1", "uniprot_id": [ { "id": "RIF1_CHICK", "url": "https://www.uniprot.org/uniprot/E1C2U2", "type": "external" } ], "mass": 254281.0, "length": 2326, "protein_name": "Telomere-associated protein RIF1", "gene_name": "RIF1", "organism": "Chicken", "refseq_name": "telomere-associated protein RIF1 isoform X1", "refseq_ac": [ { "id": "XP_015145353", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015145353", "type": "external" } ], "gene_names_uniprotkb": "RIF1", "gene_names_refseq": "RIF1", "protein_names_uniprotkb": "Telomere-associated protein RIF1; Rap1-interacting factor 1 homolog", "protein_names_refseq": "telomere-associated protein RIF1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:424316)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15592404;23333306", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015145353.1. COMPLETENESS: full length., [RefSeq]; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:23333306). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23333306). In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PUQ3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0035861 site of double-strand break;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0045830 positive regulation of isotype switching", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "E1C2U2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1C2W7-1", "uniprot_id": [ { "id": "RN152_CHICK", "url": "https://www.uniprot.org/uniprot/E1C2W7", "type": "external" } ], "mass": 22239.0, "length": 203, "protein_name": "E3 ubiquitin-protein ligase RNF152", "gene_name": "RNF152", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase RNF152", "refseq_ac": [ { "id": "NP_001291963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291963", "type": "external" } ], "gene_names_uniprotkb": "RNF152", "gene_names_refseq": "RNF152", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF152; 2.3.2.27; RING finger protein 152; RING-type E3 ubiquitin transferase RNF152", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF152; RING-type E3 ubiquitin transferase RNF152", "tax_id": 9031, "disease": "", "pathway": " (gga:420909); (R-GGA-8866654)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15592404", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB. Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling. Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation., [UniProtKB, UniProtKB]; VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR391296.1, BU337928.1, BU415530.1 and BI394494.1. On or before Feb 18, 2015 this sequence version replaced XP_004939755.1, XP_004939754.1. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031267 small GTPase binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0010508 positive regulation of autophagy;GO:0070936 protein K48-linked ubiquitination;GO:0034198 cellular response to amino acid starvation;GO:0070534 protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1C2W7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1C3A1-1", "uniprot_id": [ { "id": "E1C3A1_CHICK", "url": "https://www.uniprot.org/uniprot/E1C3A1", "type": "external" } ], "mass": 110142.0, "length": 966, "protein_name": "Kinesin-like protein", "gene_name": "KIF5B", "organism": "Chicken", "refseq_name": "kinesin-1 heavy chain isoform X1", "refseq_ac": [ { "id": "XP_418574", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_418574", "type": "external" } ], "gene_names_uniprotkb": "KIF5B", "gene_names_refseq": "KIF5B", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin-1 heavy chain isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005874 microtubule;GO:0035253 ciliary rootlet;GO:0005871 kinesin complex", "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0032230 positive regulation of synaptic transmission, GABAergic;GO:0043268 positive regulation of potassium ion transport;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1C3A1-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1C3M4-1", "uniprot_id": [ { "id": "E1C3M4_CHICK", "url": "https://www.uniprot.org/uniprot/E1C3M4", "type": "external" } ], "mass": 50820.0, "length": 468, "protein_name": "Adenylyltransferase and sulfurtransferase MOCS3", "gene_name": "MOCS3", "organism": "Chicken", "refseq_name": "adenylyltransferase and sulfurtransferase MOCS3", "refseq_ac": [ { "id": "XP_001232656", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001232656", "type": "external" } ], "gene_names_uniprotkb": "MOCS3; UBA4", "gene_names_refseq": "MOCS3", "protein_names_uniprotkb": "Adenylyltransferase and sulfurtransferase MOCS3; Adenylyltransferase MOCS3; Molybdenum cofactor synthesis protein 3; Sulfur carrier protein MOCS2A adenylyltransferase; Sulfur carrier protein MOCS2A sulfurtransferase; Sulfurtransferase MOCS3", "protein_names_refseq": "adenylyltransferase and sulfurtransferase MOCS3", "tax_id": 9031, "disease": "", "pathway": " (gga:769390); (R-GGA-947581)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052551.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.80", "type": "external" }, { "id": "2.8.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.11", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016779 nucleotidyltransferase activity;GO:0004792 thiosulfate-cyanide sulfurtransferase activity;GO:0042292 URM1 activating enzyme activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0032447 protein urmylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1C3M4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1C3P6-1", "uniprot_id": [ { "id": "E1C3P6_CHICK", "url": "https://www.uniprot.org/uniprot/E1C3P6", "type": "external" } ], "mass": 60649.0, "length": 544, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "PAK1", "organism": "Chicken", "refseq_name": "serine/threonine-protein kinase PAK 1", "refseq_ac": [ { "id": "NP_001155844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155844", "type": "external" } ], "gene_names_uniprotkb": "PAK1", "gene_names_refseq": "PAK1", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "p21 protein (Cdc42/Rac)-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); serine/threonine-protein kinase PAK 1", "tax_id": 9031, "disease": "", "pathway": " (gga:419083); (R-GGA-2029482); (R-GGA-2871796); (R-GGA-389359); (R-GGA-3928662); (R-GGA-3928664); (R-GGA-399954); (R-GGA-445144); (R-GGA-5218920); (R-GGA-5621575); (R-GGA-5627123); (R-GGA-5687128); (R-GGA-8964616); (R-GGA-9013149); (R-GGA-9013404); (R-GGA-9013406); (R-GGA-9013407); (R-GGA-9013420); (R-GGA-9013423); (R-GGA-9013424)", "pathway_count": 20, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: ERR2368565.88621.1, SRR13267659.306789.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000028.1. On or before Jun 21, 2009 this sequence version replaced XP_417275.1, XP_001231309.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.18", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005518 collagen binding;GO:0031267 small GTPase binding;GO:0043015 gamma-tubulin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0060244 negative regulation of cell proliferation involved in contact inhibition;GO:1903608 protein localization to cytoplasmic stress granule;GO:0006338 chromatin remodeling;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1C3P6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1C5V0-1", "uniprot_id": [ { "id": "SMYD2_CHICK", "url": "https://www.uniprot.org/uniprot/E1C5V0", "type": "external" } ], "mass": 49947.0, "length": 436, "protein_name": "N-lysine methyltransferase SMYD2", "gene_name": "SMYD2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SMYD2", "gene_names_refseq": "", "protein_names_uniprotkb": "N-lysine methyltransferase SMYD2; 2.1.1.-; 2.1.1.354; Histone methyltransferase SMYD2; SET and MYND domain-containing protein 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15592404", "class_list": "", "function": "Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000993 RNA polymerase II complex binding;GO:0046975 histone H3K36 methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity;GO:0140999 histone H3K4 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1C5V0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NBC9-1", "uniprot_id": [ { "id": "F1NBC9_CHICK", "url": "https://www.uniprot.org/uniprot/F1NBC9", "type": "external" } ], "mass": 44655.0, "length": 397, "protein_name": "ATP-sensitive inward rectifier potassium channel 11", "gene_name": "KCNJ11", "organism": "Chicken", "refseq_name": "ATP-sensitive inward rectifier potassium channel 11", "refseq_ac": [ { "id": "XP_426402", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_426402", "type": "external" } ], "gene_names_uniprotkb": "KCNJ11", "gene_names_refseq": "KCNJ11", "protein_names_uniprotkb": "ATP-sensitive inward rectifier potassium channel 11; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 11", "tax_id": 9031, "disease": "", "pathway": " (gga:428846); (R-GGA-1296025); (R-GGA-382556); (R-GGA-422356); (R-GGA-5578775)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_426402.4. COMPLETENESS: full length., [RefSeq]; Inward rectifier potassium channel that forms the pore of ATP-sensitive potassium channels (KATP), regulating potassium permeability as a function of cytoplasmic ATP and ADP concentrations in many different cells. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium. In pancreatic cells, it forms KATP channels with ABCC8/SUR1. Can form cardiac and smooth muscle-type KATP channels with ABCC9., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0044325 transmembrane transporter binding;GO:0015272 ATP-activated inward rectifier potassium channel activity;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0008282 inward rectifying potassium channel;GO:0030315 T-tubule", "go_biological_process": "GO:0050877 nervous system process;GO:0046676 negative regulation of insulin secretion;GO:0006006 glucose metabolic process;GO:0009410 response to xenobiotic stimulus;GO:0033198 response to ATP", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NBC9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NBT0-1", "uniprot_id": [ { "id": "STK10_CHICK", "url": "https://www.uniprot.org/uniprot/F1NBT0", "type": "external" } ], "mass": 112504.0, "length": 969, "protein_name": "Serine/threonine-protein kinase 10", "gene_name": "STK10", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "STK10", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase 10; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15592404", "class_list": "", "function": "May act as a polo kinase kinase by mediating phosphorylation of PLK1., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0046777 protein autophosphorylation;GO:2000401 regulation of lymphocyte migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1NBT0-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1ND88-1", "uniprot_id": [ { "id": "F1ND88_CHICK", "url": "https://www.uniprot.org/uniprot/F1ND88", "type": "external" } ], "mass": 30066.0, "length": 269, "protein_name": "Insulin-like growth factor-binding protein 5", "gene_name": "IGFBP5", "organism": "Chicken", "refseq_name": "insulin-like growth factor-binding protein 5", "refseq_ac": [ { "id": "XP_422069", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_422069", "type": "external" } ], "gene_names_uniprotkb": "IGFBP5", "gene_names_refseq": "IGFBP5", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 5", "protein_names_refseq": "insulin-like growth factor-binding protein 5", "tax_id": 9031, "disease": "", "pathway": " (gga:424220); (R-GGA-381426); (R-GGA-8957275)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_422069.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001968 fibronectin binding;GO:0048018 receptor ligand activity;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0042567 insulin-like growth factor ternary complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0071320 cellular response to cAMP;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation;GO:0017148 negative regulation of translation;GO:0014912 negative regulation of smooth muscle cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1ND88-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NEY2-1", "uniprot_id": [ { "id": "F1NEY2_CHICK", "url": "https://www.uniprot.org/uniprot/F1NEY2", "type": "external" } ], "mass": 39708.0, "length": 357, "protein_name": "Opsin-5", "gene_name": "OPN5", "organism": "Chicken", "refseq_name": "opsin-5 isoform X2", "refseq_ac": [ { "id": "XP_040553243", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040553243", "type": "external" } ], "gene_names_uniprotkb": "OPN5", "gene_names_refseq": "GPR136; GRP136; OPN5; Opn5m; PGR12; TMEM13; cOpn5m; neuropsin; opsin-5", "protein_names_uniprotkb": "Opsin-5; G-protein coupled receptor 136; G-protein coupled receptor PGR12; Neuropsin", "protein_names_refseq": "opsin-5 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-418594); (R-GGA-419771)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032795 heterotrimeric G-protein binding;GO:0005503 all-trans retinal binding;GO:0005502 11-cis retinal binding;GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043204 perikaryon;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:1990384 hyaloid vascular plexus regression;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0090303 positive regulation of wound healing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NEY2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NIA5-1", "uniprot_id": [ { "id": "F1NIA5_CHICK", "url": "https://www.uniprot.org/uniprot/F1NIA5", "type": "external" } ], "mass": 43358.0, "length": 374, "protein_name": "RNA demethylase ALKBH5", "gene_name": "ALKBH5", "organism": "Chicken", "refseq_name": "RNA demethylase ALKBH5", "refseq_ac": [ { "id": "NP_001244130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001244130", "type": "external" } ], "gene_names_uniprotkb": "ALKBH5", "gene_names_refseq": "ALKBH5", "protein_names_uniprotkb": "RNA demethylase ALKBH5; 1.14.11.53; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5", "protein_names_refseq": "RNA demethylase ALKBH5; alkB homolog 5, RNA demethylase", "tax_id": 9031, "disease": "", "pathway": " (gga:770703); (R-GGA-73943)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888528.412516.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. On Jul 9, 2016 this sequence version replaced XP_001233463.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0035515 oxidative RNA demethylase activity;GO:1990931 mRNA N6-methyladenosine dioxygenase activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0042382 paraspeckles", "go_biological_process": "GO:0006397 mRNA processing;GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0001666 response to hypoxia;GO:0061157 mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NIA5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NJH8-1", "uniprot_id": [ { "id": "F1NJH8_CHICK", "url": "https://www.uniprot.org/uniprot/F1NJH8", "type": "external" } ], "mass": 96547.0, "length": 843, "protein_name": "Transient receptor potential cation channel subfamily V member 1", "gene_name": "TRPV1", "organism": "Chicken", "refseq_name": "transient receptor potential cation channel subfamily V member 1 isoform X2", "refseq_ac": [ { "id": "XP_040505945", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040505945", "type": "external" } ], "gene_names_uniprotkb": "TRPV1", "gene_names_refseq": "TRPV1", "protein_names_uniprotkb": "Transient receptor potential cation channel subfamily V member 1; Osm-9-like TRP channel 1; Vanilloid receptor 1", "protein_names_refseq": "transient receptor potential cation channel subfamily V member 1 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-3295583)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052550.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane;GO:0032591 dendritic spine membrane", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:0050965 detection of temperature stimulus involved in sensory perception of pain;GO:0071468 cellular response to acidic pH;GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NJH8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NKP4-1", "uniprot_id": [ { "id": "F1NKP4_CHICK", "url": "https://www.uniprot.org/uniprot/F1NKP4", "type": "external" } ], "mass": 69526.0, "length": 622, "protein_name": "Phosphoenolpyruvate carboxykinase, cytosolic [GTP]", "gene_name": "PCK1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PCK1", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; 4.1.1.32; Serine-protein kinase PCK1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396458); (R-GGA-70263)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0030145 manganese ion binding;GO:0031406 carboxylic acid binding;GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0046327 glycerol biosynthetic process from pyruvate;GO:0009792 embryo development ending in birth or egg hatching;GO:0019563 glycerol catabolic process;GO:0007296 vitellogenesis;GO:0032869 cellular response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NKP4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NKQ7-1", "uniprot_id": [ { "id": "F1NKQ7_CHICK", "url": "https://www.uniprot.org/uniprot/F1NKQ7", "type": "external" } ], "mass": 22820.0, "length": 195, "protein_name": "FAS-associated death domain protein", "gene_name": "FADD", "organism": "Chicken", "refseq_name": "FAS-associated death domain protein", "refseq_ac": [ { "id": "XP_421073", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_421073", "type": "external" } ], "gene_names_uniprotkb": "FADD", "gene_names_refseq": "FADD", "protein_names_uniprotkb": "FAS-associated death domain protein; FAS-associating death domain-containing protein; Fas-associated death domain protein", "protein_names_refseq": "FAS-associated death domain protein", "tax_id": 9031, "disease": "", "pathway": " (gga:423146); (R-GGA-140534); (R-GGA-2562578); (R-GGA-3371378); (R-GGA-5218900); (R-GGA-5357786); (R-GGA-5357905); (R-GGA-5675482); (R-GGA-69416); (R-GGA-75157); (R-GGA-75158)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_421073.1. COMPLETENESS: full length., [RefSeq]; Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0035591 signaling adaptor activity;GO:0035877 death effector domain binding;GO:0089720 caspase binding;GO:0005123 death receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0031265 CD95 death-inducing signaling complex;GO:0097342 ripoptosome", "go_biological_process": "GO:0045087 innate immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051607 defense response to virus;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0048536 spleen development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NKQ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NKX5-1", "uniprot_id": [ { "id": "F1NKX5_CHICK", "url": "https://www.uniprot.org/uniprot/F1NKX5", "type": "external" } ], "mass": 38823.0, "length": 357, "protein_name": "Neurogenic differentiation factor", "gene_name": "NEUROD1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NEUROD1", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurogenic differentiation factor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395754)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046982 protein heterodimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032024 positive regulation of insulin secretion;GO:0043065 positive regulation of apoptotic process;GO:0045666 positive regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NKX5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NMB0-1", "uniprot_id": [ { "id": "F1NMB0_CHICK", "url": "https://www.uniprot.org/uniprot/F1NMB0", "type": "external" } ], "mass": 168511.0, "length": 1504, "protein_name": "Glutamate receptor", "gene_name": "GRIN2B", "organism": "Chicken", "refseq_name": "glutamate receptor ionotropic, NMDA 2B", "refseq_ac": [ { "id": "XP_040516439", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040516439", "type": "external" } ], "gene_names_uniprotkb": "GRIN2B", "gene_names_refseq": "GRIN2B", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, NMDA 2B", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-3928662); (R-GGA-438066); (R-GGA-5673001); (R-GGA-8849932); (R-GGA-9609736)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052573.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022849 glutamate-gated calcium ion channel activity;GO:0046872 metal ion binding;GO:0005234 extracellularly glutamate-gated ion channel activity;GO:0016594 glycine binding;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0017146 NMDA selective glutamate receptor complex;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007613 memory;GO:0045471 response to ethanol;GO:0060079 excitatory postsynaptic potential;GO:0014049 positive regulation of glutamate secretion;GO:0035249 synaptic transmission, glutamatergic", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NMB0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NMQ4-1", "uniprot_id": [ { "id": "F1NMQ4_CHICK", "url": "https://www.uniprot.org/uniprot/F1NMQ4", "type": "external" } ], "mass": 48195.0, "length": 414, "protein_name": "tRNA methyltransferase 10 homolog C", "gene_name": "TRMT10C", "organism": "Chicken", "refseq_name": "tRNA methyltransferase 10 homolog C isoform X2", "refseq_ac": [ { "id": "XP_015152676", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015152676", "type": "external" } ], "gene_names_uniprotkb": "TRMT10C", "gene_names_refseq": "TRMT10C", "protein_names_uniprotkb": "tRNA methyltransferase 10 homolog C; 2.1.1.218; 2.1.1.221; Mitochondrial ribonuclease P protein 1; RNA (guanine-9-)-methyltransferase domain-containing protein 1; mRNA methyladenosine-N(1)-methyltransferase; tRNA (adenine(9)-N(1))-methyltransferase; tRNA (guanine(9)-N(1))-methyltransferase", "protein_names_refseq": "tRNA methyltransferase 10 homolog C isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:418397)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221", "type": "external" }, { "id": "2.1.1.220", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.220", "type": "external" }, { "id": "2.1.1.218", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity;GO:0160106 tRNA (adenine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006397 mRNA processing;GO:0070131 positive regulation of mitochondrial translation;GO:0070901 mitochondrial tRNA methylation;GO:0001680 tRNA 3'-terminal CCA addition;GO:1990180 mitochondrial tRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NMQ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NMR6-1", "uniprot_id": [ { "id": "F1NMR6_CHICK", "url": "https://www.uniprot.org/uniprot/F1NMR6", "type": "external" } ], "mass": 29952.0, "length": 292, "protein_name": "Paired like homeobox 2B", "gene_name": "PHOX2B", "organism": "Chicken", "refseq_name": "paired mesoderm homeobox protein 2B", "refseq_ac": [ { "id": "XP_015140956", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015140956", "type": "external" } ], "gene_names_uniprotkb": "PHOX2B", "gene_names_refseq": "PHOX2B", "protein_names_uniprotkb": "Paired like homeobox 2B", "protein_names_refseq": "paired mesoderm homeobox protein 2B", "tax_id": 9031, "disease": "", "pathway": " (gga:395548)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0003360 brainstem development;GO:0048484 enteric nervous system development;GO:0021723 medullary reticular formation development;GO:0048486 parasympathetic nervous system development;GO:0061452 retrotrapezoid nucleus neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NMR6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NTD6-1", "uniprot_id": [ { "id": "ASCC3_CHICK", "url": "https://www.uniprot.org/uniprot/F1NTD6", "type": "external" } ], "mass": 251857.0, "length": 2211, "protein_name": "Activating signal cointegrator 1 complex subunit 3", "gene_name": "ascc3", "organism": "Chicken", "refseq_name": "activating signal cointegrator 1 complex subunit 3", "refseq_ac": [ { "id": "NP_001292140", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292140", "type": "external" } ], "gene_names_uniprotkb": "ascc3", "gene_names_refseq": "ASCC3", "protein_names_uniprotkb": "Activating signal cointegrator 1 complex subunit 3; 5.6.2.4", "protein_names_refseq": "activating signal cointegrator 1 complex subunit 3", "tax_id": 9031, "disease": "", "pathway": " (gga:421790); (R-GGA-9954716)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15592404", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000065.1. On Mar 4, 2015 this sequence version replaced XP_419816.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Also involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Drives the splitting of stalled ribosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0022626 cytosolic ribosome;GO:0180022 RQC-trigger complex", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006307 DNA alkylation repair;GO:1990116 ribosome-associated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1NTD6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NW29-1", "uniprot_id": [ { "id": "TYDP2_CHICK", "url": "https://www.uniprot.org/uniprot/F1NW29", "type": "external" } ], "mass": 41002.0, "length": 369, "protein_name": "Tyrosyl-DNA phosphodiesterase 2", "gene_name": "TDP2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TDP2", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosyl-DNA phosphodiesterase 2; 3.1.4.-; 5'-Tyr-DNA phosphodiesterase; 5'-tyrosyl-DNA phosphodiesterase; Tyr-DNA phosphodiesterase 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:421007)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15592404;22740648", "class_list": "", "function": "DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation (By similarity). Also has 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0003697 single-stranded DNA binding;GO:0004518 nuclease activity;GO:0070260 5'-tyrosyl-DNA phosphodiesterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016605 PML body", "go_biological_process": "GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1NW29-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PXN4-1", "uniprot_id": [ { "id": "A0A1D5PXN4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PXN4", "type": "external" } ], "mass": 78480.0, "length": 685, "protein_name": "Protein kinase C delta type", "gene_name": "PRKCD", "organism": "Chicken", "refseq_name": "protein kinase C delta type isoform X1", "refseq_ac": [ { "id": "XP_015148252", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015148252", "type": "external" } ], "gene_names_uniprotkb": "PRKCD", "gene_names_refseq": "PRKCD", "protein_names_uniprotkb": "Protein kinase C delta type; 2.7.11.13; nPKC-delta", "protein_names_refseq": "protein kinase C delta type isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:415905); (R-GGA-111465); (R-GGA-111933); (R-GGA-114508); (R-GGA-1489509); (R-GGA-2029485); (R-GGA-450520); (R-GGA-5218921); (R-GGA-5607764); (R-GGA-5668599); (R-GGA-6798695); (R-GGA-877300)", "pathway_count": 12, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052543.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1C5S5", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity;GO:0004699 diacylglycerol-dependent, calcium-independent serine/threonine kinase activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0007165 signal transduction;GO:0006915 apoptotic process;GO:0042307 positive regulation of protein import into nucleus;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:1904385 cellular response to angiotensin", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PXN4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NV46-1", "uniprot_id": [ { "id": "A0A1D5NV46_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NV46", "type": "external" } ], "mass": 61604.0, "length": 561, "protein_name": "glycerol kinase", "gene_name": "GK2", "organism": "Chicken", "refseq_name": "glycerol kinase isoform X1", "refseq_ac": [ { "id": "XP_003640559", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003640559", "type": "external" } ], "gene_names_uniprotkb": "GK2", "gene_names_refseq": "GK2", "protein_names_uniprotkb": "glycerol kinase; 2.7.1.30; ATP:glycerol 3-phosphotransferase", "protein_names_refseq": "glycerol kinase isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:418589); (R-GGA-75109)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 19, 2013 this sequence version replaced XP_003640559.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.30", "type": "external" } ], "go_molecular_function": "GO:0004370 glycerol kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:0006071 glycerol metabolic process;GO:0006072 glycerol-3-phosphate metabolic process;GO:0046167 glycerol-3-phosphate biosynthetic process;GO:0006641 triglyceride metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NV46-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NTY7-1", "uniprot_id": [ { "id": "A0A1D5NTY7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NTY7", "type": "external" } ], "mass": 43854.0, "length": 380, "protein_name": "Fibromodulin", "gene_name": "FMOD", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FMOD", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibromodulin; Keratan sulfate proteoglycan fibromodulin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395814); (R-GGA-2022854); (R-GGA-2022857); (R-GGA-6794361)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NTY7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NTR5-1", "uniprot_id": [ { "id": "A0A1D5NTR5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NTR5", "type": "external" } ], "mass": 307472.0, "length": 2774, "protein_name": "Teneurin-2", "gene_name": "TENM2", "organism": "Chicken", "refseq_name": "teneurin-2 isoform 2", "refseq_ac": [ { "id": "NP_001003718", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003718", "type": "external" } ], "gene_names_uniprotkb": "TENM2", "gene_names_refseq": "ODZ2; TEN2; TENM2", "protein_names_uniprotkb": "Teneurin-2; Protein Odd Oz/ten-m homolog 2; Tenascin-M2; Teneurin transmembrane protein 2", "protein_names_refseq": "neurestin; odd Oz/ten-m homolog 2; odz, odd Oz/ten-m homolog 2; protein Odd Oz/ten-m homolog 2; ten-2; ten-m2; tenascin-M2; teneurin-2 isoform 2; teneurin-2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "18366734", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000256.1. On or before Dec 16, 2021 this sequence version replaced XP_040502733.1, NP_001003718.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Induces gene transcription inhibition., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a ligand of the ADGRL1 and ADGRL3 receptors that are expressed at the surface of adjacent cells. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Teneurin-1 and -2 are expressed by distinct interconnected populations of neurons in the developing central nervous system Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0030426 growth cone;GO:0043197 dendritic spine;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex;GO:0006351 DNA-templated transcription;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5NTR5-1", "record_type": "protein", "filter_code": "0000000.0000100.001000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17926-1", "uniprot_id": [ { "id": "NFIC_CHICK", "url": "https://www.uniprot.org/uniprot/P17926", "type": "external" } ], "mass": 49233.0, "length": 439, "protein_name": "Nuclear factor 1 C-type", "gene_name": "NFIC", "organism": "Chicken", "refseq_name": "nuclear factor 1 C-type isoform 5", "refseq_ac": [ { "id": "NP_001384233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001384233", "type": "external" } ], "gene_names_uniprotkb": "NFIC; NFI-C", "gene_names_refseq": "CNFI-C; NFIC", "protein_names_uniprotkb": "Nuclear factor 1 C-type; CCAAT-box-binding transcription factor; CTF; NF-I/C; NF1-C; NFI-C; Nuclear factor 1/C; Nuclear factor I/C; TGGCA-binding protein", "protein_names_refseq": "CCAAT-box-binding transcription factor; CTF; NF-I/C; NF1-C; NFI-C; TGGCA-binding protein; nuclear factor 1 C-type isoform 5; nuclear factor 1 C-type; nuclear factor 1/C; nuclear factor I-C1; nuclear factor I/C (CCAAT-binding transcription factor)", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2339052", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X51483.1, SRR13267649.187277.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000374.1., [RefSeq]; Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006260 DNA replication;GO:0045893 positive regulation of DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P17926-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1P1X4-1", "uniprot_id": [ { "id": "F1P1X4_CHICK", "url": "https://www.uniprot.org/uniprot/F1P1X4", "type": "external" } ], "mass": 307179.0, "length": 2700, "protein_name": "Inositol 1,4,5-trisphosphate receptor", "gene_name": "ITPR2", "organism": "Chicken", "refseq_name": "inositol 1,4,5-trisphosphate receptor type 2 isoform X1", "refseq_ac": [ { "id": "XP_015146920", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015146920", "type": "external" } ], "gene_names_uniprotkb": "ITPR2", "gene_names_refseq": "ITPR2", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate receptor", "protein_names_refseq": "inositol 1,4,5-trisphosphate receptor type 2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:418212); (R-GGA-114508); (R-GGA-139853); (R-GGA-381676); (R-GGA-5578775); (R-GGA-983695)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity., [UniProtKB, UniProtKB]; Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005220 inositol 1,4,5-trisphosphate-gated calcium channel activity;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0097110 scaffold protein binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0030658 transport vesicle membrane;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0043235 receptor complex", "go_biological_process": "GO:0051209 release of sequestered calcium ion into cytosol;GO:0071320 cellular response to cAMP;GO:0001666 response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1P1X4-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZML9-1", "uniprot_id": [ { "id": "SETD3_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZML9", "type": "external" } ], "mass": 67196.0, "length": 593, "protein_name": "Actin-histidine N-methyltransferase", "gene_name": "SETD3", "organism": "Chicken", "refseq_name": "actin-histidine N-methyltransferase", "refseq_ac": [ { "id": "NP_001006486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006486", "type": "external" } ], "gene_names_uniprotkb": "SETD3; RCJMB04_1k10", "gene_names_refseq": "SETD3", "protein_names_uniprotkb": "Actin-histidine N-methyltransferase; 2.1.1.85; Protein-L-histidine N-tele-methyltransferase; SET domain-containing protein 3", "protein_names_refseq": "SET domain-containing protein 3; actin-histidine N-methyltransferase; histone-lysine N-methyltransferase setd3; protein-L-histidine N-tele-methyltransferase", "tax_id": 9031, "disease": "", "pathway": " (gga:423445)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15592404;15642098;18612635", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719365.1, SRR13267655.113391.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000215.1. On Jan 13, 2005 this sequence version replaced XP_421355.1., [RefSeq]; Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73'. Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E1C6M7", "ec_number_list": [ { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003779 actin binding;GO:0018064 protein-L-histidine N-tele-methyltransferase activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0042800 histone H3K4 methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0030047 actin modification;GO:0018021 peptidyl-histidine methylation;GO:0032259 methylation;GO:0070472 regulation of uterine smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5ZML9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29332-1", "uniprot_id": [ { "id": "CCNB2_CHICK", "url": "https://www.uniprot.org/uniprot/P29332", "type": "external" } ], "mass": 44652.0, "length": 399, "protein_name": "G2/mitotic-specific cyclin-B2", "gene_name": "CCNB1; CCNB2", "organism": "Chicken", "refseq_name": "G2/mitotic-specific cyclin-B2", "refseq_ac": [ { "id": "NP_001004369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004369", "type": "external" } ], "gene_names_uniprotkb": "CCNB1; CCNB2; CYCB2", "gene_names_refseq": "CCNB1; CCNB2; cycB2", "protein_names_uniprotkb": "G2/mitotic-specific cyclin-B2", "protein_names_refseq": "G2/mitotic-specific cyclin-B2; cyclin B2", "tax_id": 9031, "disease": "", "pathway": " (gga:415400); (R-GGA-2500257); (R-GGA-2565942); (R-GGA-2980767); (R-GGA-2995383); (R-GGA-3301854); (R-GGA-69273)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "1532584", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01000047.1, HAEK01001221.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000245.1. On Sep 17, 2004 this sequence version replaced XP_413784.1., [RefSeq]; Essential for the control of the cell cycle at the G2/M (mitosis) transition., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0051301 cell division;GO:0000082 G1/S transition of mitotic cell cycle;GO:0060317 cardiac epithelial to mesenchymal transition;GO:0044772 mitotic cell cycle phase transition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P29332-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZHQ5-1", "uniprot_id": [ { "id": "CHPT1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZHQ5", "type": "external" } ], "mass": 37091.0, "length": 335, "protein_name": "Cholinephosphotransferase 1", "gene_name": "CHPT1", "organism": "Chicken", "refseq_name": "cholinephosphotransferase 1", "refseq_ac": [ { "id": "NP_001025935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025935", "type": "external" } ], "gene_names_uniprotkb": "CHPT1; RCJMB04_34i2", "gene_names_refseq": "CHPT1", "protein_names_uniprotkb": "Cholinephosphotransferase 1; 2.7.8.2; Diacylglycerol cholinephosphotransferase 1", "protein_names_refseq": "cholinephosphotransferase 1; diacylglycerol cholinephosphotransferase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:418098); (R-GGA-1483191)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ721079.1, SRR13267659.155155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. On Aug 8, 2005 this sequence version replaced XP_416331.1., [RefSeq]; Catalyzes the final step of de novo phosphatidylcholine (PC) synthesis, i.e. the transfer of choline phosphate from CDP-choline to the free hydroxyl of a diacylglycerol (DAG), producing a PC. It thereby plays a central role in the formation and maintenance of vesicular membranes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.2", "type": "external" }, { "id": "2.7.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.1", "type": "external" }, { "id": "2.7.8.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.22", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004142 diacylglycerol cholinephosphotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006663 platelet activating factor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZHQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20135-1", "uniprot_id": [ { "id": "GSTT1_CHICK", "url": "https://www.uniprot.org/uniprot/P20135", "type": "external" } ], "mass": 29823.0, "length": 261, "protein_name": "Glutathione S-transferase theta-1", "gene_name": "GSTT1", "organism": "Chicken", "refseq_name": "glutathione S-transferase theta-1 isoform 1", "refseq_ac": [ { "id": "NP_990696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990696", "type": "external" } ], "gene_names_uniprotkb": "GSTT1", "gene_names_refseq": "GSTT1", "protein_names_uniprotkb": "Glutathione S-transferase theta-1; 2.5.1.18; GST class-theta; GST-CL1", "protein_names_refseq": "GST class-theta; GST-CL1; glutathione S-transferase theta-1 isoform 1; theta glutathione-S-transferase", "tax_id": 9031, "disease": "", "pathway": " (gga:396322); (R-GGA-156590)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "2337594;7492340", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267652.14951.1, U13676.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000260.1., [RefSeq]; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P20135-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07460-1", "uniprot_id": [ { "id": "IF5A2_CHICK", "url": "https://www.uniprot.org/uniprot/Q07460", "type": "external" } ], "mass": 16720.0, "length": 153, "protein_name": "Eukaryotic translation initiation factor 5A-2", "gene_name": "EIF5A2", "organism": "Chicken", "refseq_name": "eukaryotic translation initiation factor 5A-2", "refseq_ac": [ { "id": "NP_990863", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990863", "type": "external" } ], "gene_names_uniprotkb": "EIF5A2", "gene_names_refseq": "EIF5A2; EIF5A; eIF-5A", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5A-2; Eukaryotic initiation factor 5A isoform 2; eIF-4D; eIF-5A-2; eIF-5A2", "protein_names_refseq": "eIF-4D; eIF-5A-2; eIF-5A2; eukaryotic initiation factor 5A; eukaryotic translation initiation factor 5A-2; eukaryotic translation initiation factor 5A; initiation factor 5A", "tax_id": 9031, "disease": "", "pathway": " (gga:396545); (R-GGA-204626)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1556119;7916728", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267652.8588.1, M99499.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1., [RefSeq]; Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q07460-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F3G7-1", "uniprot_id": [ { "id": "C1GLT_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F3G7", "type": "external" } ], "mass": 42620.0, "length": 366, "protein_name": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1", "gene_name": "C1GALT1", "organism": "Chicken", "refseq_name": "glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1", "refseq_ac": [ { "id": "NP_001012575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012575", "type": "external" } ], "gene_names_uniprotkb": "C1GALT1; RCJMB04_17i7", "gene_names_refseq": "C1GALT1", "protein_names_uniprotkb": "Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; 2.4.1.122; C1GalT1; Core 1 O-glycan T-synthase; Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; Core 1 beta1,3-galactosyltransferase 1; Core 1 beta3-Gal-T1", "protein_names_refseq": "core 1 O-glycan T-synthase; core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; core 1 beta1,3-galactosyltransferase 1; core 1 beta3-Gal-T1; core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1; glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:420575); (R-GGA-913709)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15642098", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851683.1, SRR13267649.111534.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000036.1. On Feb 28, 2005 this sequence version replaced XP_418676.1., [RefSeq]; Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.122", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0016263 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0001822 kidney development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F3G7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W689-1", "uniprot_id": [ { "id": "ATX3_CHICK", "url": "https://www.uniprot.org/uniprot/Q9W689", "type": "external" } ], "mass": 41608.0, "length": 363, "protein_name": "Ataxin-3", "gene_name": "ATXN3", "organism": "Chicken", "refseq_name": "ataxin-3", "refseq_ac": [ { "id": "NP_989688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989688", "type": "external" } ], "gene_names_uniprotkb": "ATXN3; MDJ1; MJD", "gene_names_refseq": "ATXN3L; ATXN3; Ataxin-3; MDJ1; MJD1; MJD", "protein_names_uniprotkb": "Ataxin-3; 3.4.19.12; Machado-Joseph disease protein 1 homolog", "protein_names_refseq": "ataxin 3 like; ataxin-3; machado-Joseph disease protein 1 homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:378424); (R-GGA-5689877); (R-GGA-9615017)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10023088;12486728", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01014926.1, SRR13267649.112040.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992604 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000215.1., [RefSeq]; Deubiquitinating enzyme involved in protein homeostasis maintenance, transcription, cytoskeleton regulation, myogenesis and degradation of misfolded chaperone substrates (By similarity). Binds long polyubiquitin chains and trims them, while it has weak or no activity against chains of 4 or less ubiquitins (By similarity). Involved in degradation of misfolded chaperone substrates via its interaction with STUB1/CHIP: recruited to monoubiquitinated STUB1/CHIP, and restricts the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity). Interacts with key regulators of transcription and represses transcription: acts as a histone-binding protein that regulates transcription (By similarity). Acts as a negative regulator of mTORC1 signaling in response to amino acid deprivation by mediating deubiquitination of RHEB, thereby promoting RHEB inactivation by the TSC-TBC complex (By similarity). Regulates autophagy via the deubiquitination of 'Lys-402' of BECN1 leading to the stabilization of BECN1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" } ], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005765 lysosomal membrane;GO:0016363 nuclear matrix;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0034198 cellular response to amino acid starvation;GO:1904294 positive regulation of ERAD pathway;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9W689-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W6V2-1", "uniprot_id": [ { "id": "NEGR1_CHICK", "url": "https://www.uniprot.org/uniprot/Q9W6V2", "type": "external" } ], "mass": 37944.0, "length": 352, "protein_name": "Neuronal growth regulator 1", "gene_name": "NEGR1", "organism": "Chicken", "refseq_name": "neuronal growth regulator 1 precursor", "refseq_ac": [ { "id": "NP_990187", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990187", "type": "external" } ], "gene_names_uniprotkb": "NEGR1; NTRA", "gene_names_refseq": "NEGR1; NTRA-L; NTRA-S", "protein_names_uniprotkb": "Neuronal growth regulator 1; Neurotractin", "protein_names_refseq": "neuronal growth regulator 1 precursor; neurotractin-L; neurotractin-S", "tax_id": 9031, "disease": "", "pathway": " (gga:395662)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10330412", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ132999.1, ERR2368565.298907.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000239.1., [RefSeq]; May be involved in cell-adhesion. May participate in the regulation of neurite outgrowth in the developing brain., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q9W6V1", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane;GO:0005770 late endosome", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9W6V2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25433-1", "uniprot_id": [ { "id": "NTF3_CHICK", "url": "https://www.uniprot.org/uniprot/P25433", "type": "external" } ], "mass": 29701.0, "length": 257, "protein_name": "Neurotrophin-3", "gene_name": "NTF3", "organism": "Chicken", "refseq_name": "neurotrophin-3 isoform 2 preproprotein", "refseq_ac": [ { "id": "NP_001026659", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026659", "type": "external" } ], "gene_names_uniprotkb": "NTF3", "gene_names_refseq": "HDNF; NGF-2; NGF2; NT-3; NT3; NTF3; neurotrophin-3", "protein_names_uniprotkb": "Neurotrophin-3; HDNF; NGF-2; NT-3; Nerve growth factor 2; Neurotrophic factor", "protein_names_refseq": "nerve growth factor 2; neurotrophic factor; neurotrophin-3 isoform 2 preproprotein", "tax_id": 9031, "disease": "", "pathway": " (gga:428099)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1457809;15254910;2025430;24252516;8074744", "class_list": "", "function": "Neurotrophin-3 and TrkC are expressed in the outflow tract of the developing chicken heart, [RefSeq, PubMed]; Seems to promote the survival of visceral and proprioceptive sensory neurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The chemotactic response of NCCs toward the ocular region NT-3 gradient is essential for spatiotemporal cell orientation, amplifying the functional scope of this neurotrophic factor as a molecular guide for the embryo cells., [RefSeq, PubMed]; VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and is also intronless. The encoded protein (isoform 2) is shorter and has a distinct N-terminus, compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q6LAC6", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005165 neurotrophin receptor binding;GO:0042056 chemoattractant activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0002092 positive regulation of receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P25433-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W6S3-1", "uniprot_id": [ { "id": "SIN1_CHICK", "url": "https://www.uniprot.org/uniprot/Q9W6S3", "type": "external" } ], "mass": 59221.0, "length": 522, "protein_name": "Target of rapamycin complex 2 subunit MAPKAP1", "gene_name": "MAPKAP1", "organism": "Chicken", "refseq_name": "target of rapamycin complex 2 subunit MAPKAP1", "refseq_ac": [ { "id": "NP_990157", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990157", "type": "external" } ], "gene_names_uniprotkb": "MAPKAP1; SIN1", "gene_names_refseq": "MAPKAP1; SIN1", "protein_names_uniprotkb": "Target of rapamycin complex 2 subunit MAPKAP1; Mitogen-activated protein kinase 2-associated protein 1; SAPK-interacting protein 1; Stress-activated map kinase-interacting protein 1; TORC2 subunit MAPKAP1", "protein_names_refseq": "SAPK interacting protein; SAPK-interacting protein 1; TORC2 subunit MAPKAP1; mitogen-activated protein kinase 2-associated protein 1; stress-activated map kinase-interacting protein 1; target of rapamycin complex 2 subunit MAPKAP1", "tax_id": 9031, "disease": "", "pathway": " (gga:395627); (R-GGA-1257604); (R-GGA-389357); (R-GGA-5218920); (R-GGA-6804757); (R-GGA-9856530)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "10428959", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF153127.2, SRR13267655.102423.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000308.1. Sequence Note: This sequence has been modified as follows: removed 17 bp suspected to be vector contamination from the 5' end., [RefSeq]; Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output. In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1. In contrast to mTORC1, mTORC2 is nutrient-insensitive. Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019901 protein kinase binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005769 early endosome", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0032869 cellular response to insulin stimulus;GO:1900407 regulation of cellular response to oxidative stress;GO:0038203 TORC2 signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9W6S3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6U1I9-1", "uniprot_id": [ { "id": "SGK1_CHICK", "url": "https://www.uniprot.org/uniprot/Q6U1I9", "type": "external" } ], "mass": 48890.0, "length": 432, "protein_name": "Serine/threonine-protein kinase Sgk1", "gene_name": "SGK1", "organism": "Chicken", "refseq_name": "serine/threonine-protein kinase Sgk1", "refseq_ac": [ { "id": "NP_989807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989807", "type": "external" } ], "gene_names_uniprotkb": "SGK1; SGK", "gene_names_refseq": "SGK1; SGK", "protein_names_uniprotkb": "Serine/threonine-protein kinase Sgk1; 2.7.11.1; Serum/glucocorticoid-regulated kinase 1", "protein_names_refseq": "serine/threonine-protein kinase Sgk1; serum- and glucocorticoid-induced kinase", "tax_id": 9031, "disease": "", "pathway": " (gga:395133); (R-GGA-1257604); (R-GGA-2672351); (R-GGA-6804757); (R-GGA-9031628)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY380825.1, HAEK01071472.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000063.1., [RefSeq]; Protein kinase that may play an important role in cellular stress response. May be involved in the regulation of processes such as cell survival, neuronal excitability and renal sodium excretion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0015459 potassium channel regulator activity;GO:0106310 protein serine kinase activity;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016607 nuclear speck", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0006915 apoptotic process;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6U1I9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1P023-1", "uniprot_id": [ { "id": "F1P023_CHICK", "url": "https://www.uniprot.org/uniprot/F1P023", "type": "external" } ], "mass": 102401.0, "length": 922, "protein_name": "Solute carrier family 8 member A3", "gene_name": "COX16", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COX16", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 8 member A3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395759); (R-GGA-418359); (R-GGA-425561); (R-GGA-5578775)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0005432 calcium:sodium antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0005743 mitochondrial inner membrane;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0007154 cell communication;GO:0007612 learning;GO:0007613 memory;GO:0006874 intracellular calcium ion homeostasis;GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1P023-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJS0-1", "uniprot_id": [ { "id": "KC1G1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJS0", "type": "external" } ], "mass": 52194.0, "length": 456, "protein_name": "Casein kinase I isoform gamma-1", "gene_name": "CSNK1G1", "organism": "Chicken", "refseq_name": "casein kinase I isoform gamma-1", "refseq_ac": [ { "id": "NP_001005800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005800", "type": "external" } ], "gene_names_uniprotkb": "CSNK1G1; RCJMB04_16d5", "gene_names_refseq": "CSNK1G1; CTD-2116N17.1", "protein_names_uniprotkb": "Casein kinase I isoform gamma-1; 2.7.11.1; CKI-gamma 1", "protein_names_refseq": "CKI-gamma 1; casein kinase I isoform gamma-1; casein kinase I, gamma 1", "tax_id": 9031, "disease": "", "pathway": " (gga:415328)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720364.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA3109053 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ720364.1. On May 5, 2006 this sequence version replaced XP_413715.1., [RefSeq]; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0016055 Wnt signaling pathway;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJS0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21566-1", "uniprot_id": [ { "id": "COF2_CHICK", "url": "https://www.uniprot.org/uniprot/P21566", "type": "external" } ], "mass": 18662.0, "length": 166, "protein_name": "Cofilin-2", "gene_name": "CFL2", "organism": "Chicken", "refseq_name": "cofilin-2", "refseq_ac": [ { "id": "NP_001004406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004406", "type": "external" } ], "gene_names_uniprotkb": "CFL2", "gene_names_refseq": "CFL2; cofilin-2", "protein_names_uniprotkb": "Cofilin-2; Cofilin, muscle isoform", "protein_names_refseq": "cofilin 2 (muscle); cofilin-2", "tax_id": 9031, "disease": "", "pathway": " (gga:423320)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11885570;1699599;17823847;23250207;29749375", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01006275.1, HAEL01002176.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000215.1. On Sep 23, 2021 this sequence version replaced NP_001004406.1., [RefSeq]; Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods., [UniProtKB]; Our results suggest that the activity of A3-cofilin and also S3-cofilin can be regulated by PIP(2) in the cytoplasm of muscle cells., [RefSeq, PubMed]; Study reports chicken cofilactin (cofilin-decorated actin filament) 3.8 A resolution cryo-electron microscopy structure which enables to determine the nature of the cofilin-binding-induced conformational transition in the actin subunit. The cofilin-actin interface consists of three distinct parts and cofilin preferentially binds ADP-F-actin versus ATP-actin. Publication Status: Online-Only, [RefSeq, PubMed]; Type Ib BMP receptors mediate the rate of commissural axon extension through inhibition of cofilin activity, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0016363 nuclear matrix;GO:0030018 Z disc", "go_biological_process": "GO:0051014 actin filament severing;GO:0030043 actin filament fragmentation;GO:0030042 actin filament depolymerization;GO:0007519 skeletal muscle tissue development;GO:0030836 positive regulation of actin filament depolymerization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P21566-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08284-1", "uniprot_id": [ { "id": "H101_CHICK", "url": "https://www.uniprot.org/uniprot/P08284", "type": "external" } ], "mass": 22044.0, "length": 219, "protein_name": "Histone H1.01", "gene_name": "H1-01", "organism": "Chicken", "refseq_name": "histone H1.01", "refseq_ac": [ { "id": "NP_001035732", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035732", "type": "external" } ], "gene_names_uniprotkb": "H1-01", "gene_names_refseq": "H1-01; HIST1H101", "protein_names_uniprotkb": "Histone H1.01", "protein_names_refseq": "histone H1.01; histone cluster 1, H1.01 (similar to human histone cluster 1, class H1 genes)", "tax_id": 9031, "disease": "", "pathway": " (gga:417954); (R-GGA-140342); (R-GGA-2559584)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "4000927", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: SRR13267659.275366.1, DR427756.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On May 16, 2006 this sequence version replaced XP_416194.1., [RefSeq]; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P08284-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZL67-1", "uniprot_id": [ { "id": "NF2L1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZL67", "type": "external" } ], "mass": 85186.0, "length": 772, "protein_name": "Endoplasmic reticulum membrane sensor NFE2L1", "gene_name": "NFE2L1", "organism": "Chicken", "refseq_name": "endoplasmic reticulum membrane sensor NFE2L1", "refseq_ac": [ { "id": "NP_001025927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025927", "type": "external" } ], "gene_names_uniprotkb": "NFE2L1; NRF1; RCJMB04_7g14", "gene_names_refseq": "NFE2L1; NRF1", "protein_names_uniprotkb": "Endoplasmic reticulum membrane sensor NFE2L1; NF-E2-related factor 1; NFE2-related factor 1; Nuclear factor erythroid 2-related factor 1; Nuclear factor, erythroid derived 2, like 1", "protein_names_refseq": "NF-E2-related factor 1; NFE2-related factor 1; endoplasmic reticulum membrane sensor NFE2L1; nuclear factor (erythroid-derived 2)-like 1; nuclear factor erythroid 2-related factor 1", "tax_id": 9031, "disease": "", "pathway": " (gga:417987)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719867.1, SRR13267659.69892.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04013384, SAMN06140854 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ719867.1. On Aug 8, 2005 this sequence version replaced XP_416226.1., [RefSeq]; CNC-type bZIP family transcription factor that translocates to the nucleus and regulates expression of target genes in response to various stresses. Heterodimerizes with small-Maf proteins (MAFF, MAFG or MAFK) and binds DNA motifs including the antioxidant response elements (AREs), which regulate expression of genes involved in oxidative stress response. Activates or represses expression of target genes, depending on the context (By similarity). Plays a key role in cholesterol homeostasis by acting as a sensor of cholesterol excess: in low cholesterol conditions, translocates into the nucleus and represses expression of genes involved in defense against cholesterol excess (By similarity). In excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity). Critical for redox balance in response to oxidative stress: acts by binding the AREs motifs on promoters and mediating activation of oxidative stress response genes (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, mediates the 'bounce-back' of proteasome subunits by translocating into the nucleus and activating expression of genes encoding proteasome subunits (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor (By similarity). Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition (By similarity). In response to stress, it is released from the endoplasmic reticulum membrane following cleavage and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal (By similarity). Involved in proteasome homeostasis: in response to proteasome inhibition, it is released from the endoplasmic reticulum membrane, translocates to the nucleus and activates expression of genes encoding proteasome subunits (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008203 cholesterol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZL67-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58270-1", "uniprot_id": [ { "id": "DPF3_CHICK", "url": "https://www.uniprot.org/uniprot/P58270", "type": "external" } ], "mass": 48930.0, "length": 427, "protein_name": "Zinc finger protein DPF3", "gene_name": "DPF3", "organism": "Chicken", "refseq_name": "zinc finger protein DPF3 isoform X3", "refseq_ac": [ { "id": "XP_015142411", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015142411", "type": "external" } ], "gene_names_uniprotkb": "DPF3; CERD4", "gene_names_refseq": "DPF3", "protein_names_uniprotkb": "Zinc finger protein DPF3; Zinc finger protein cer-d4", "protein_names_refseq": "zinc finger protein DPF3 isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:395351)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11845289;17640523;18765789", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4. In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and plays a role in neural development., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071565 nBAF complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0006355 regulation of DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P58270-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34996-1", "uniprot_id": [ { "id": "P2RY1_CHICK", "url": "https://www.uniprot.org/uniprot/P34996", "type": "external" } ], "mass": 41194.0, "length": 362, "protein_name": "P2Y purinoceptor 1", "gene_name": "P2RY1", "organism": "Chicken", "refseq_name": "P2Y purinoceptor 1", "refseq_ac": [ { "id": "NP_990664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990664", "type": "external" } ], "gene_names_uniprotkb": "P2RY1", "gene_names_refseq": "P2RY1", "protein_names_uniprotkb": "P2Y purinoceptor 1; ATP receptor; P2Y1; Purinergic receptor", "protein_names_refseq": "ATP receptor P2Y1; G protein-coupled receptor; P2Y purinoceptor 1; purinergic receptor P2Y, G-protein coupled, 1", "tax_id": 9031, "disease": "", "pathway": " (gga:396275); (R-GGA-416476); (R-GGA-417957); (R-GGA-418592)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "8508924;8872457", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CN210812.1, X73268.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1., [RefSeq]; Receptor for extracellular adenine nucleotides such as ADP (PubMed:8508924). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (By similarity)., [UniProtKB, UniProtKB, PubMed]; Receptor for extracellular adenine nucleotides such as ADP. In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001621 G protein-coupled ADP receptor activity;GO:0031686 A1 adenosine receptor binding;GO:0045031 G protein-coupled ATP receptor activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0090075 relaxation of muscle;GO:0030168 platelet activation;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0008360 regulation of cell shape;GO:0071415 cellular response to purine-containing compound", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P34996-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PWR1-1", "uniprot_id": [ { "id": "KCAB1_CHICK", "url": "https://www.uniprot.org/uniprot/Q9PWR1", "type": "external" } ], "mass": 44639.0, "length": 401, "protein_name": "Voltage-gated potassium channel subunit beta-1", "gene_name": "KCNAB1", "organism": "Chicken", "refseq_name": "voltage-gated potassium channel subunit beta-1", "refseq_ac": [ { "id": "NP_990237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990237", "type": "external" } ], "gene_names_uniprotkb": "KCNAB1; KVB1.1", "gene_names_refseq": "KCNAB1; KCNAB3; KVB1.1", "protein_names_uniprotkb": "Voltage-gated potassium channel subunit beta-1; 1.1.1.-; K(+) channel subunit beta-1; Kv-beta-1", "protein_names_refseq": "K(+) channel subunit beta-1; kv-beta-1; potassium channel Shaker beta 1 subunit cKvbeta1.1; potassium voltage-gated channel subfamily A regulatory beta subunit 3; potassium voltage-gated channel, shaker-related subfamily, beta member 1; putative potassim channel beta-subunit; voltage-gated potassium channel subunit beta-1", "tax_id": 9031, "disease": "", "pathway": " (gga:395730); (R-GGA-1296072)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10095080;14755528", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U87787.1, SRR13267652.17824.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05341171 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U87787.1., [RefSeq]; Regulatory subunit of the voltage-gated potassium (Kv) channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members. Promotes the inactivation of KCNA1, KCNA2, KCNA4, KCNA5 and KCNA6 alpha subunit-containing channels (By similarity). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a variety of endogenous aldehydes and ketones (By similarity). The binding of NADPH is required for efficient down-regulation of potassium channel activity (By similarity). Oxidation of the bound NADPH restrains N-terminal domain from blocking the channel, thereby decreasing N-type inactivation of potassium channel activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; We conclude that the highly specialized abundant expression of Kv1.1 and 3.1 channel subunits is not permanently regulated by synaptic activity and that changes in overall protein levels do not predict membrane pools., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.21", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0070402 NADPH binding;GO:0004090 carbonyl reductase (NADPH) activity", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005829 cytosol;GO:0008076 voltage-gated potassium channel complex;GO:0009898 cytoplasmic side of plasma membrane;GO:0044224 juxtaparanode region of axon", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0071805 potassium ion transmembrane transport;GO:0055085 transmembrane transport;GO:0006813 potassium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9PWR1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I8G9-1", "uniprot_id": [ { "id": "RBBP7_CHICK", "url": "https://www.uniprot.org/uniprot/Q9I8G9", "type": "external" } ], "mass": 47703.0, "length": 424, "protein_name": "Histone-binding protein RBBP7", "gene_name": "RBBP7", "organism": "Chicken", "refseq_name": "histone-binding protein RBBP7", "refseq_ac": [ { "id": "NP_990001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990001", "type": "external" } ], "gene_names_uniprotkb": "RBBP7; RBAP46", "gene_names_refseq": "RBBP7", "protein_names_uniprotkb": "Histone-binding protein RBBP7; RBBP-7; Retinoblastoma-binding protein 7; Retinoblastoma-binding protein p46", "protein_names_refseq": "RBBP-7; Rbap46 polypeptide; histone-binding protein RBBP7; retinoblastoma binding protein 7; retinoblastoma-binding protein p46", "tax_id": 9031, "disease": "", "pathway": " (gga:395390)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11112423", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF279275.1, HAEL01006481.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000021.1., [RefSeq]; Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex;GO:0000781 chromosome, telomeric region;GO:0016581 NuRD complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9I8G9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90965-1", "uniprot_id": [ { "id": "RAB2A_CHICK", "url": "https://www.uniprot.org/uniprot/Q90965", "type": "external" } ], "mass": 23522.0, "length": 212, "protein_name": "Ras-related protein Rab-2A", "gene_name": "RAB2A", "organism": "Chicken", "refseq_name": "ras-related protein Rab-2A", "refseq_ac": [ { "id": "NP_990559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990559", "type": "external" } ], "gene_names_uniprotkb": "RAB2A; RAB2", "gene_names_refseq": "RAB2A; RAB2", "protein_names_uniprotkb": "Ras-related protein Rab-2A; 3.6.5.2", "protein_names_refseq": "GTP-binding protein; RAB2, member RAS oncogene family; ras-related protein Rab-2A", "tax_id": 9031, "disease": "", "pathway": " (gga:396153); (R-GGA-162658)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8746459", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.153312.1, SRR13267649.225366.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000043.1., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion. Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi. Together with RAB2B, redundantly required for efficient autophagic flux., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity;GO:0019003 GDP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0042470 melanosome;GO:0001669 acrosomal vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0007030 Golgi organization;GO:0061909 autophagosome-lysosome fusion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90965-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q98907-1", "uniprot_id": [ { "id": "P2RY3_CHICK", "url": "https://www.uniprot.org/uniprot/Q98907", "type": "external" } ], "mass": 37587.0, "length": 328, "protein_name": "P2Y purinoceptor 3", "gene_name": "P2RY3; P2RY6", "organism": "Chicken", "refseq_name": "P2Y purinoceptor 3", "refseq_ac": [ { "id": "NP_990526", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990526", "type": "external" } ], "gene_names_uniprotkb": "P2RY3; P2RY6", "gene_names_refseq": "P2RY3; P2RY6; P2Y3", "protein_names_uniprotkb": "P2Y purinoceptor 3; Nucleoside diphosphate receptor; P2Y3", "protein_names_refseq": "G protein-coupled P2 receptor; P2Y purinoceptor 3; nucleoside diphosphate receptor; pyrimidinergic receptor P2Y, G-protein coupled, 6", "tax_id": 9031, "disease": "", "pathway": " (gga:396114); (R-GGA-416476); (R-GGA-417957)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8700132", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: X98283.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X98283.1., [RefSeq]; Receptor for extracellular ADP > UTP > ATP = UDP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001621 G protein-coupled ADP receptor activity;GO:0045029 G protein-coupled UDP receptor activity;GO:0045030 G protein-coupled UTP receptor activity;GO:0045028 G protein-coupled purinergic nucleotide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0032962 positive regulation of inositol trisphosphate biosynthetic process;GO:0007186 G protein-coupled receptor signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q98907-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13731-1", "uniprot_id": [ { "id": "SERPH_CHICK", "url": "https://www.uniprot.org/uniprot/P13731", "type": "external" } ], "mass": 45682.0, "length": 405, "protein_name": "Serpin H1", "gene_name": "SERPINH1", "organism": "Chicken", "refseq_name": "serpin H1 precursor", "refseq_ac": [ { "id": "NP_990622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990622", "type": "external" } ], "gene_names_uniprotkb": "SERPINH1; HSP47", "gene_names_refseq": "HSP47; SERPINH1", "protein_names_uniprotkb": "Serpin H1; 47 kDa heat shock protein; Collagen-binding protein; Colligin", "protein_names_refseq": "47 kDa heat shock protein; collagen-binding protein; colligin; heat shock protein 47; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); serpin H1 precursor; serpin H1; serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)", "tax_id": 9031, "disease": "", "pathway": " (gga:396228); (R-GGA-1650814)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "2072906;28860186;3377793", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X57157.1, SRR13267656.12717.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992432, SAMEA103992648 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000032.1., [RefSeq]; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen., [UniProtKB, UniProtKB, UniProtKB]; Results suggest that a weak interaction between Hsp47 and FKBP65 confers mutual molecular stability and also allows for a synergistic effect during collagen folding., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "P29042", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005518 collagen binding;GO:0051082 unfolded protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0045121 membrane raft;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0030199 collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P13731-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90835-1", "uniprot_id": [ { "id": "EF1A_CHICK", "url": "https://www.uniprot.org/uniprot/Q90835", "type": "external" } ], "mass": 50157.0, "length": 462, "protein_name": "Elongation factor 1-alpha 1", "gene_name": "EEF1A1; EEF1A", "organism": "Chicken", "refseq_name": "elongation factor 1-alpha 1", "refseq_ac": [ { "id": "NP_001308445", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308445", "type": "external" } ], "gene_names_uniprotkb": "EEF1A1; EEF1A", "gene_names_refseq": "EEF1A1; EEF1A; EF1A", "protein_names_uniprotkb": "Elongation factor 1-alpha 1; 3.6.5.-; EF-1-alpha-1; EF-Tu; Elongation factor Tu", "protein_names_refseq": "EF-1 alpha; EF-1-alpha-1; EF-Tu; elongation factor 1 alpha; elongation factor 1-alpha 1; elongation factor Tu", "tax_id": 9031, "disease": "", "pathway": " (gga:373963); (R-GGA-156842); (R-GGA-3371511); (R-GGA-6798695); (R-GGA-8876725)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "8144022", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01012166.1, CO635767.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000065.1., [RefSeq]; This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis., [UniProtKB, UniProtKB]; Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" } ], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005516 calmodulin binding;GO:0005525 GTP binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0032587 ruffle membrane;GO:0022626 cytosolic ribosome;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0044829 host-mediated activation of viral genome replication;GO:0006412 translation;GO:0071364 cellular response to epidermal growth factor stimulus;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90835-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PTD5-1", "uniprot_id": [ { "id": "MTFR1_CHICK", "url": "https://www.uniprot.org/uniprot/Q9PTD5", "type": "external" } ], "mass": 36979.0, "length": 335, "protein_name": "Mitochondrial fission regulator 1", "gene_name": "MTFR1", "organism": "Chicken", "refseq_name": "mitochondrial fission regulator 1", "refseq_ac": [ { "id": "NP_989874", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989874", "type": "external" } ], "gene_names_uniprotkb": "MTFR1; CHPPR", "gene_names_refseq": "CHPPR; MTFR1", "protein_names_uniprotkb": "Mitochondrial fission regulator 1; Chondrocyte protein with a poly-proline region", "protein_names_refseq": "chondrocyte protein with a poly-proline region; mitochondrial fission regulator 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395222)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12359332;15389597;15592404", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF208489.1, SRR13267659.91466.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000043.1. On Jan 4, 2015 this sequence version replaced NP_989874.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1NUU1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0007005 mitochondrion organization;GO:0000266 mitochondrial fission;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9PTD5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02659-1", "uniprot_id": [ { "id": "APOV1_CHICK", "url": "https://www.uniprot.org/uniprot/P02659", "type": "external" } ], "mass": 11966.0, "length": 106, "protein_name": "Apovitellenin-1", "gene_name": "APOV1", "organism": "Chicken", "refseq_name": "apovitellenin-1 precursor", "refseq_ac": [ { "id": "NP_990814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990814", "type": "external" } ], "gene_names_uniprotkb": "APOV1", "gene_names_refseq": "APO-II; APO-VLDL-II; APOV1; APOVLDLII; apovitellenin-1", "protein_names_uniprotkb": "Apovitellenin-1; Apo-II; Apo-VLDL-II; Apovitellenin I; Very low density lipoprotein II", "protein_names_refseq": "apovitellenin I; apovitellenin-1 precursor; very low density lipoprotein II", "tax_id": 9031, "disease": "", "pathway": " (gga:396476)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "188805;19070113;2703502;6856469;7012793;7286648;7430115;988817", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU242700.1, BU125840.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992428, SAMEA103992440 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000019.1. On Feb 22, 2015 this sequence version replaced NP_990814.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results examine the genetic polymorphism in the functional apoVLDL-II gene in domestic fowl and their precursors, red jungle fowl., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90882", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0045735 nutrient reservoir activity", "go_cellular_component": "GO:0034361 very-low-density lipoprotein particle;GO:0042627 chylomicron", "go_biological_process": "GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P02659-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8UWC1-1", "uniprot_id": [ { "id": "Q8UWC1_CHICK", "url": "https://www.uniprot.org/uniprot/Q8UWC1", "type": "external" } ], "mass": 42077.0, "length": 359, "protein_name": "Fucosyltransferase", "gene_name": "FUT9", "organism": "Chicken", "refseq_name": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9", "refseq_ac": [ { "id": "NP_001072970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072970", "type": "external" } ], "gene_names_uniprotkb": "FUT9", "gene_names_refseq": "CFUC-TIX; FUT9", "protein_names_uniprotkb": "Fucosyltransferase; 2.4.1.-", "protein_names_refseq": "4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase 9; cFUT9; fucosyltransferase 9 (alpha (1,3) fucosyltransferase)", "tax_id": 9031, "disease": "", "pathway": " (gga:771133); (R-GGA-9037629)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01101059.1, SRR12888496.19424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992428 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000065.1. On Dec 9, 2006 this sequence version replaced XP_001233361.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032588 trans-Golgi network membrane;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0000271 polysaccharide biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0010976 positive regulation of neuron projection development;GO:0006493 protein O-linked glycosylation;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q8UWC1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55807-1", "uniprot_id": [ { "id": "NRT2_CHICK", "url": "https://www.uniprot.org/uniprot/P55807", "type": "external" } ], "mass": 34966.0, "length": 312, "protein_name": "NAD(P)(+)--arginine ADP-ribosyltransferase 2", "gene_name": "ART1F", "organism": "Chicken", "refseq_name": "NAD(P)(+)--arginine ADP-ribosyltransferase 2 precursor", "refseq_ac": [ { "id": "NP_990186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990186", "type": "external" } ], "gene_names_uniprotkb": "ART1F", "gene_names_refseq": "ART1E; ART1L3; AT2; CHAT2", "protein_names_uniprotkb": "NAD(P)(+)--arginine ADP-ribosyltransferase 2; 2.4.2.31; AT2; Mono(ADP-ribosyl)transferase 2", "protein_names_refseq": "ADP-ribosyltransferase 1 like 3; NAD(P)(+)--arginine ADP-ribosyltransferase 2 precursor; NAD(P)(+)--arginine ADP-ribosyltransferase 2; NAD--arginine ADP-ribosyltransferase 2; mono(ADP-ribosyl)transferase 2", "tax_id": 9031, "disease": "", "pathway": " (gga:395661)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7961658", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267654.235684.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D31865.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" } ], "go_molecular_function": "GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0044194 cytolytic granule", "go_biological_process": "GO:0046677 response to antibiotic", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P55807-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29415-1", "uniprot_id": [ { "id": "CXA3_CHICK", "url": "https://www.uniprot.org/uniprot/P29415", "type": "external" } ], "mass": 55793.0, "length": 511, "protein_name": "Gap junction alpha-3 protein", "gene_name": "GJA3", "organism": "Chicken", "refseq_name": "gap junction alpha-3 protein", "refseq_ac": [ { "id": "NP_001035734", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035734", "type": "external" } ], "gene_names_uniprotkb": "GJA3", "gene_names_refseq": "GJA3", "protein_names_uniprotkb": "Gap junction alpha-3 protein; Connexin-56; Cx56", "protein_names_refseq": "connexin-56; cx56; gap junction alpha-3 protein; gap junction protein, alpha 3, 46kDa (connexin 46)", "tax_id": 9031, "disease": "", "pathway": " (gga:428084); (R-GGA-190861)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "14762116;27143357;7678009;9063450", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888532.307506.1, SRR12888545.83187.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000027.1. On or before Dec 7, 2021 this sequence version replaced XP_015133700.1, XP_425642.1., [RefSeq]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB, UniProtKB, UniProtKB]; Structural component of lens fiber gap junctions (PubMed:7678009). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:7678009)., [UniProtKB, PubMed, UniProtKB]; Structural component of lens fiber gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore., [UniProtKB, UniProtKB, UniProtKB]; The role of the charged residues at the end of TM-1 in voltage sensing in Cx26, Cx46, and Cx50., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0055077 gap junction hemi-channel activity;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:1990349 gap junction-mediated intercellular transport;GO:0007154 cell communication", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P29415-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90771-1", "uniprot_id": [ { "id": "Q90771_CHICK", "url": "https://www.uniprot.org/uniprot/Q90771", "type": "external" } ], "mass": 36850.0, "length": 326, "protein_name": "cyclin-dependent kinase", "gene_name": "CDK6", "organism": "Chicken", "refseq_name": "cyclin-dependent kinase 6 isoform 1", "refseq_ac": [ { "id": "NP_001007893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007893", "type": "external" } ], "gene_names_uniprotkb": "CDK6", "gene_names_refseq": "CDK6", "protein_names_uniprotkb": "cyclin-dependent kinase; 2.7.11.22", "protein_names_refseq": "cell division protein kinase 6; cyclin-dependent kinase 6 isoform 1", "tax_id": 9031, "disease": "", "pathway": " (gga:420558); (R-GGA-2559580); (R-GGA-2559582); (R-GGA-2559585); (R-GGA-69231); (R-GGA-8934593); (R-GGA-9754119)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "18305152", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267654.270302.1, SRR13267648.22894.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000036.1. On Dec 15, 2004 this sequence version replaced XP_418659.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Cdk6 up-regulation in TDP-43-depleted cells is accompanied by an increase in phosphorylation of two of its major targets, the retinoblastoma protein pRb and pRb-related protein pRb2/p130., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0098770 FBXO family protein binding;GO:0030332 cyclin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0050680 negative regulation of epithelial cell proliferation;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90771-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90987-1", "uniprot_id": [ { "id": "STMN2_CHICK", "url": "https://www.uniprot.org/uniprot/Q90987", "type": "external" } ], "mass": 20882.0, "length": 179, "protein_name": "Stathmin-2", "gene_name": "STMN2", "organism": "Chicken", "refseq_name": "stathmin-2", "refseq_ac": [ { "id": "NP_990512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990512", "type": "external" } ], "gene_names_uniprotkb": "STMN2; SCG10", "gene_names_refseq": "SCG10; STMN2; stathmin-2", "protein_names_uniprotkb": "Stathmin-2; Protein SCG10; Superior cervical ganglion-10 protein", "protein_names_refseq": "Protein SCG10; stathmin-2; stathmin-like 2; superior cervical ganglion-10 protein", "tax_id": 9031, "disease": "", "pathway": " (gga:396095)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8735217", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01003281.1, HAEL01000108.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000044.1. On Aug 30, 2004 this sequence version replaced XP_444650.1., [RefSeq]; Is a key regulator of neurite extension through regulation of microtubule instabilily., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0030027 lamellipodium;GO:0030426 growth cone;GO:0043025 neuronal cell body", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0031117 positive regulation of microtubule depolymerization;GO:0010976 positive regulation of neuron projection development;GO:0031175 neuron projection development;GO:1990090 cellular response to nerve growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90987-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F389-1", "uniprot_id": [ { "id": "WWOX_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F389", "type": "external" } ], "mass": 46730.0, "length": 414, "protein_name": "WW domain-containing oxidoreductase", "gene_name": "WWOX", "organism": "Chicken", "refseq_name": "WW domain-containing oxidoreductase", "refseq_ac": [ { "id": "NP_001025745", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025745", "type": "external" } ], "gene_names_uniprotkb": "WWOX; RCJMB04_28b1", "gene_names_refseq": "WWOX", "protein_names_uniprotkb": "WW domain-containing oxidoreductase; 1.1.1.-", "protein_names_refseq": "WW domain-containing oxidoreductase", "tax_id": 9031, "disease": "", "pathway": " (gga:415801); (R-GGA-1251985); (R-GGA-8866904); (R-GGA-8866907)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851761.1, HAEK01049546.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000248.1. On Mar 18, 2015 this sequence version replaced NP_001025745.1., [RefSeq]; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Required for normal bone development. Inhibits Wnt signaling (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway;GO:0016055 Wnt signaling pathway;GO:0071560 cellular response to transforming growth factor beta stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F389-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6RK82-1", "uniprot_id": [ { "id": "F6RK82_CHICK", "url": "https://www.uniprot.org/uniprot/F6RK82", "type": "external" } ], "mass": 45886.0, "length": 413, "protein_name": "Nucleic acid dioxygenase ALKBH1", "gene_name": "ALKBH1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ALKBH1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleic acid dioxygenase ALKBH1; 1.14.11.33; 1.14.11.51; 4.2.99.18; Alkylated DNA repair protein alkB homolog 1; Alpha-ketoglutarate-dependent dioxygenase ABH1; DNA 6mA demethylase; DNA N6-methyl adenine demethylase ALKBH1; DNA lyase ABH1; DNA oxidative demethylase ALKBH1; mRNA N(3)-methylcytidine demethylase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33", "type": "external" }, { "id": "1.14.11.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.54", "type": "external" }, { "id": "1.14.11.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.53", "type": "external" }, { "id": "1.14.11.51", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0035516 broad specificity oxidative DNA demethylase activity;GO:0141131 DNA N6-methyladenine demethylase activity;GO:0042056 chemoattractant activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0000791 euchromatin", "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0042245 RNA repair;GO:1990983 regulation of translational initiation by tRNA modification;GO:0141137 positive regulation of gene expression, epigenetic", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F6RK82-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZHV1-1", "uniprot_id": [ { "id": "RB33B_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZHV1", "type": "external" } ], "mass": 25736.0, "length": 228, "protein_name": "Ras-related protein Rab-33B", "gene_name": "RAB33B", "organism": "Chicken", "refseq_name": "ras-related protein Rab-33B", "refseq_ac": [ { "id": "NP_001008466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008466", "type": "external" } ], "gene_names_uniprotkb": "RAB33B; RCJMB04_32p6", "gene_names_refseq": "RAB33B", "protein_names_uniprotkb": "Ras-related protein Rab-33B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-33B", "tax_id": 9031, "disease": "", "pathway": " (gga:422441); (R-GGA-6811438)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ721033.1, SRR13267655.233190.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000073.1. On Dec 16, 2004 this sequence version replaced XP_420408.1., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB33B acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. Participates in autophagosome formation by recruiting the ATG12-ATG5-ATG16L1 complex to phagophores, probably in a nucleotide-independent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005796 Golgi lumen;GO:0034045 phagophore assembly site membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0034497 protein localization to phagophore assembly site;GO:0048705 skeletal system morphogenesis;GO:0034067 protein localization to Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZHV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I946-1", "uniprot_id": [ { "id": "PDGFC_CHICK", "url": "https://www.uniprot.org/uniprot/Q9I946", "type": "external" } ], "mass": 38940.0, "length": 345, "protein_name": "Platelet-derived growth factor C", "gene_name": "PDGFC", "organism": "Chicken", "refseq_name": "platelet-derived growth factor C precursor", "refseq_ac": [ { "id": "NP_990052", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990052", "type": "external" } ], "gene_names_uniprotkb": "PDGFC; SCDGF", "gene_names_refseq": "PDGFC; SCDGF", "protein_names_uniprotkb": "Platelet-derived growth factor C; PDGF-C; Spinal cord-derived growth factor", "protein_names_refseq": "PDGF-C; platelet-derived growth factor C precursor; spinal cord-derived growth factor", "tax_id": 9031, "disease": "", "pathway": " (gga:395469); (R-GGA-186797)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10858496;19705434", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267648.13081.1, AB033829.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000071.1., [RefSeq]; Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, in angiogenesis and blood vessel development (By similarity)., [UniProtKB, PubMed]; Results describe the expression patterns of PDGF-A, -C, and their receptor PDGFR-alpha during avian heart development., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0008083 growth factor activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0051781 positive regulation of cell division", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9I946-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90W79-1", "uniprot_id": [ { "id": "CNTN5_CHICK", "url": "https://www.uniprot.org/uniprot/Q90W79", "type": "external" } ], "mass": 113048.0, "length": 1027, "protein_name": "Contactin-5", "gene_name": "CNTN5", "organism": "Chicken", "refseq_name": "contactin-5 precursor", "refseq_ac": [ { "id": "NP_989943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989943", "type": "external" } ], "gene_names_uniprotkb": "CNTN5; FAR2", "gene_names_refseq": "CNTN5; FAR-2; FAR2; contactin-5", "protein_names_uniprotkb": "Contactin-5; F11 axonin-1-related protein 2; FAR-2", "protein_names_refseq": "F11 axonin-1-related protein 2; FAR-2 protein fragment; contactin-5 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:395317); (R-GGA-163125)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "11461156", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ309935.1, SRR13267659.17086.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ309935.1., [RefSeq]; Contactins mediate cell surface interactions during nervous system development. May contribute to the formation of somatotopic maps of cerebellar afferents during the development of the nervous system., [UniProtKB, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0098552 side of membrane;GO:0098982 GABA-ergic synapse;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0099054 presynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90W79-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZIV7-1", "uniprot_id": [ { "id": "DESI2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZIV7", "type": "external" } ], "mass": 21409.0, "length": 193, "protein_name": "Deubiquitinase DESI2", "gene_name": "DESI2", "organism": "Chicken", "refseq_name": "deubiquitinase DESI2", "refseq_ac": [ { "id": "NP_001008460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008460", "type": "external" } ], "gene_names_uniprotkb": "DESI2; FAM152A; PPPDE1; RCJMB04_23d23", "gene_names_refseq": "C1orf121; CGI-146; DESI1; DESI2; DESI; DeSI-2; FAM152A; PNAS-4; PPPDE1", "protein_names_uniprotkb": "Deubiquitinase DESI2; 3.1.2.22; 3.4.19.12; DeSI-2; Desumoylating isopeptidase 2; PPPDE peptidase domain-containing protein 1; Palmitoyl protein thioesterase DESI2; Protein FAM152A; S-depalmitoylase DESI2", "protein_names_refseq": "PPPDE peptidase domain containing 1; PPPDE peptidase domain-containing protein 1; Protein FAM152A; S-depalmitoylase DESI2; desumoylating isopeptidase 1; deubiquitinase DESI2; family with sequence similarity 152, member A; palmitoyl protein thioesterase DESI2", "tax_id": 9031, "disease": "", "pathway": " (gga:421494)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720677.1, SRR13267654.5562.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000063.1. On Dec 16, 2004 this sequence version replaced XP_419541.1., [RefSeq]; Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity;GO:0101005 deubiquitinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZIV7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07354-1", "uniprot_id": [ { "id": "HPLN1_CHICK", "url": "https://www.uniprot.org/uniprot/P07354", "type": "external" } ], "mass": 40533.0, "length": 355, "protein_name": "Hyaluronan and proteoglycan link protein 1", "gene_name": "HAPLN1", "organism": "Chicken", "refseq_name": "hyaluronan and proteoglycan link protein 1 precursor", "refseq_ac": [ { "id": "NP_990813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990813", "type": "external" } ], "gene_names_uniprotkb": "HAPLN1; CRTL1", "gene_names_refseq": "CRTL1; HAPLN1L; HAPLN1", "protein_names_uniprotkb": "Hyaluronan and proteoglycan link protein 1; Cartilage-link protein; Cartilage-linking protein 1; Proteoglycan link protein", "protein_names_refseq": "cartilage link protein; cartilage-linking protein 1; hyaluronan and proteoglycan link protein 1 precursor; proteoglycan link protein", "tax_id": 9031, "disease": "", "pathway": " (gga:396475); (R-GGA-3000178)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1985942;3459154;3476955", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.268155.1, SRR13267651.6444.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000095.1., [RefSeq]; Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0045202 synapse;GO:0072534 perineuronal net;GO:0140150 gel phase of interstitial matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P07354-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90871-1", "uniprot_id": [ { "id": "IRF8_CHICK", "url": "https://www.uniprot.org/uniprot/Q90871", "type": "external" } ], "mass": 49171.0, "length": 425, "protein_name": "Interferon regulatory factor 8", "gene_name": "IRF8", "organism": "Chicken", "refseq_name": "interferon regulatory factor 8", "refseq_ac": [ { "id": "NP_990747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990747", "type": "external" } ], "gene_names_uniprotkb": "IRF8; ICSBP1; ICSBP", "gene_names_refseq": "ICSBP1; ICSBP; IRF8", "protein_names_uniprotkb": "Interferon regulatory factor 8; ICSBP; IRF-8; Interferon consensus sequence-binding protein", "protein_names_refseq": "IRF-8; interferon consensus sequence binding protein; interferon regulatory factor 8", "tax_id": 9031, "disease": "", "pathway": " (gga:396385)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19047367;7536924", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L39767.1, ERR2286007.66784.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992639 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L39767.1., [RefSeq]; IRF-4 and IRF-8, two lymphoid cell-specific transcription factors, increase telomerase activity by activating TERT transcription in immune cells., [RefSeq, PubMed]; Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune system (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0002273 plasmacytoid dendritic cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90871-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZHS1-1", "uniprot_id": [ { "id": "ELP3_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZHS1", "type": "external" } ], "mass": 62092.0, "length": 546, "protein_name": "Elongator complex protein 3", "gene_name": "ELP3", "organism": "Chicken", "refseq_name": "elongator complex protein 3", "refseq_ac": [ { "id": "NP_001034382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034382", "type": "external" } ], "gene_names_uniprotkb": "ELP3; RCJMB04_33o1", "gene_names_refseq": "ELP3", "protein_names_uniprotkb": "Elongator complex protein 3; 2.3.1.311; tRNA uridine(34) acetyltransferase", "protein_names_refseq": "elongation protein 3 homolog; elongator complex protein 3; tRNA uridine(34) acetyltransferase", "tax_id": 9031, "disease": "", "pathway": " (gga:422021)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ721063.1, HAEK01000768.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000070.1. On Jan 31, 2006 this sequence version replaced XP_420028.1., [RefSeq]; Catalytic tRNA acetyltransferase subunit of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Not a major acetyltransferase of tubulin (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.311", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.311", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0000049 tRNA binding;GO:0106261 tRNA uridine(34) acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0033588 elongator holoenzyme complex;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0002098 tRNA wobble uridine modification;GO:0002926 tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation;GO:0030335 positive regulation of cell migration;GO:0001764 neuron migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZHS1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "U3NEE3-1", "uniprot_id": [ { "id": "HNMTL_CHICK", "url": "https://www.uniprot.org/uniprot/U3NEE3", "type": "external" } ], "mass": 36375.0, "length": 322, "protein_name": "Carnosine N-methyltransferase 2", "gene_name": "LOC771456", "organism": "Chicken", "refseq_name": "carnosine N-methyltransferase 2", "refseq_ac": [ { "id": "NP_001305361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305361", "type": "external" } ], "gene_names_uniprotkb": "LOC771456", "gene_names_refseq": "HNMT-like; LOC771456", "protein_names_uniprotkb": "Carnosine N-methyltransferase 2; 2.1.1.22; HNMT-like; Histamine N-methyltransferase-like", "protein_names_refseq": "carnosine N-methyltransferase 2", "tax_id": 9031, "disease": "", "pathway": " (gga:771456)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15592404;23705015", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: KF271750.1, SRR12888540.193823.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000236.1., [RefSeq]; Carnosine N-methyltransferase was purified from chicken muscle, a rich source of the enzyme, characterized and identified using mass spectrometry analysis. GeneRIF: Chicken histamine N-methyltransferase-like gene encodes carnosine N-methyltransferase that catalyzes the transfer of methyl group of S-adenosyl-L-methionine to carnosine, yielding anserine. Publication Status: Online-Only, [RefSeq, PubMed]; N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.22", "type": "external" } ], "go_molecular_function": "GO:0008170 N-methyltransferase activity;GO:0030735 carnosine N-methyltransferase activity", "go_cellular_component": "", "go_biological_process": "GO:0032259 methylation;GO:0035498 carnosine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "U3NEE3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6JLB1-1", "uniprot_id": [ { "id": "Q6JLB1_CHICK", "url": "https://www.uniprot.org/uniprot/Q6JLB1", "type": "external" } ], "mass": 33175.0, "length": 302, "protein_name": "TATA-box binding protein", "gene_name": "TBP", "organism": "Chicken", "refseq_name": "TATA-box-binding protein", "refseq_ac": [ { "id": "NP_001383119", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383119", "type": "external" } ], "gene_names_uniprotkb": "TBP", "gene_names_refseq": "TBP1; TBP", "protein_names_uniprotkb": "TATA-box binding protein", "protein_names_refseq": "TA-TA binding protein 1; TATA sequence-binding protein; TATA-binding factor; TATA-binding protein; TATA-box factor; TATA-box-binding protein; transcription initiation factor TFIID TBP subunit", "tax_id": 9031, "disease": "", "pathway": " (gga:395995); (R-GGA-5250924); (R-GGA-674695); (R-GGA-6807505); (R-GGA-73762); (R-GGA-73772); (R-GGA-73776); (R-GGA-73779); (R-GGA-73863); (R-GGA-75953); (R-GGA-76042); (R-GGA-76061); (R-GGA-76066); (R-GGA-76071); (R-GGA-9018519)", "pathway_count": 15, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267660.17174.1, SRR13267659.316513.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000063.1., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1RPU7;F7BGR1", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0001093 TFIIB-class transcription factor binding;GO:0019899 enzyme binding;GO:0017162 aryl hydrocarbon receptor binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005668 RNA polymerase transcription factor SL1 complex;GO:0005737 cytoplasm;GO:0001939 female pronucleus;GO:0000791 euchromatin", "go_biological_process": "GO:0006352 DNA-templated transcription initiation;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0042789 mRNA transcription by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6JLB1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19352-1", "uniprot_id": [ { "id": "TPM2_CHICK", "url": "https://www.uniprot.org/uniprot/P19352", "type": "external" } ], "mass": 32777.0, "length": 284, "protein_name": "Tropomyosin beta chain", "gene_name": "TPM2", "organism": "Chicken", "refseq_name": "tropomyosin beta chain isoform X1", "refseq_ac": [ { "id": "XP_015132746", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015132746", "type": "external" } ], "gene_names_uniprotkb": "TPM2", "gene_names_refseq": "BRT-2; TPM2; TPM3; beta-tropomyosin; tropomyosin-2", "protein_names_uniprotkb": "Tropomyosin beta chain; Beta-tropomyosin; Tropomyosin-2", "protein_names_refseq": "tropomyosin beta chain isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-390522); (R-GGA-445355)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "2914939;2927392;3997867;6548747", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04267;P19353", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005884 actin filament;GO:0015629 actin cytoskeleton;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P19352-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZL19-1", "uniprot_id": [ { "id": "STX6_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZL19", "type": "external" } ], "mass": 29155.0, "length": 254, "protein_name": "Syntaxin-6", "gene_name": "STX10; STX6", "organism": "Chicken", "refseq_name": "syntaxin-6", "refseq_ac": [ { "id": "NP_001006531", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006531", "type": "external" } ], "gene_names_uniprotkb": "STX10; STX6; RCJMB04_8d16", "gene_names_refseq": "STX10; STX6; syntaxin-6", "protein_names_uniprotkb": "Syntaxin-6", "protein_names_refseq": "syntaxin 6; syntaxin-6", "tax_id": 9031, "disease": "", "pathway": " (gga:424413); (R-GGA-6811438); (R-GGA-6811440)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719915.1, HAEK01028905.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000237.1. On Jan 13, 2005 this sequence version replaced XP_422256.1., [RefSeq]; SNARE promoting movement of transport vesicles to target membranes. Targets endosomes to the trans-Golgi network, and may therefore function in retrograde trafficking. Together with SNARE STX12, promotes movement of vesicles from endosomes to the cell membrane, and may therefore function in the endocytic recycling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005829 cytosol;GO:0032588 trans-Golgi network membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0032880 regulation of protein localization;GO:0007032 endosome organization;GO:0042147 retrograde transport, endosome to Golgi;GO:0048193 Golgi vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZL19-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98165-1", "uniprot_id": [ { "id": "VLDLR_CHICK", "url": "https://www.uniprot.org/uniprot/P98165", "type": "external" } ], "mass": 94905.0, "length": 863, "protein_name": "Very low-density lipoprotein receptor", "gene_name": "VLDLR", "organism": "Chicken", "refseq_name": "very low-density lipoprotein receptor precursor", "refseq_ac": [ { "id": "NP_990560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990560", "type": "external" } ], "gene_names_uniprotkb": "VLDLR; VTGR", "gene_names_refseq": "LR8; VLDLR; VLDL; VTGR", "protein_names_uniprotkb": "Very low-density lipoprotein receptor; VLDL receptor; VLDL-R; VTG receptor; Vitellogenin receptor", "protein_names_refseq": "VLDL receptor; VLDL-R; VTG receptor; very low density lipoprotein (VLDL)/vitellogenin receptor; very low-density lipoprotein receptor precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:396154); (R-GGA-8866376); (R-GGA-8866427)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16041564;1655760;16677794;24519818;7957081", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X80207.1, SRR13267661.1942.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000089.1., [RefSeq]; Elevated circulating estrogen and/or decreased progesterone levels may have contributed to the upregulation of progesterone receptor mRNA and isoforms A and B in the pituitary gland of restricted ovulator hen, which have a point mutation in VLDLR., [RefSeq, PubMed]; LR8 binds, internalizes, and deposits the major yolk components in the ratio of their relative abundance in the accessible pool., [RefSeq, PubMed]; Multifunctional cell surface receptor that binds VLDL and transports it into cells by endocytosis and therefore plays an important role in energy metabolism. Also binds to a wide range of other molecules including Reelin/RELN or apolipoprotein E/APOE-containing ligands as well as clusterin/CLU. In the off-state of the pathway, forms homooligomers or heterooligomers with LRP8. Upon binding to ligands, homooligomers are rearranged to higher order receptor clusters that transmit the extracellular RELN signal to intracellular signaling processes by binding to DAB1 (By similarity). This interaction results in phosphorylation of DAB1 leading to the ultimate cell responses required for the correct positioning of newly generated neurons. Later, mediates a stop signal for migrating neurons, preventing them from entering the marginal zone (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; VLDLR transcripts are expressed in the tendon blastemas. Reelin inhibits tenogenic differentiation through VLDLR., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034185 apolipoprotein binding;GO:0005509 calcium ion binding;GO:0030228 lipoprotein particle receptor activity;GO:0048306 calcium-dependent protein binding;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0034361 very-low-density lipoprotein particle;GO:0098978 glutamatergic synapse;GO:0043235 receptor complex", "go_biological_process": "GO:0006869 lipid transport;GO:0006897 endocytosis;GO:0008203 cholesterol metabolic process;GO:0021517 ventral spinal cord development;GO:0034436 glycoprotein transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P98165-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90XB3-1", "uniprot_id": [ { "id": "OLIG2_CHICK", "url": "https://www.uniprot.org/uniprot/Q90XB3", "type": "external" } ], "mass": 30319.0, "length": 298, "protein_name": "Oligodendrocyte transcription factor 2", "gene_name": "OLIG2", "organism": "Chicken", "refseq_name": "oligodendrocyte transcription factor 2", "refseq_ac": [ { "id": "NP_001026697", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026697", "type": "external" } ], "gene_names_uniprotkb": "OLIG2", "gene_names_refseq": "OLIG2", "protein_names_uniprotkb": "Oligodendrocyte transcription factor 2; Oligo2", "protein_names_refseq": "bHLH protein OLIG2; bHLH transcription factor Olig2; oligo2; oligodendrocyte transcription factor 2", "tax_id": 9031, "disease": "", "pathway": " (gga:428612)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11567616;11567617;19088088", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF411041.1, BM490103.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF411041.1. On Aug 8, 2005 this sequence version replaced XP_426169.1., [RefSeq]; Electroporation of an Olig3 expression vector in the hindbrain suppressed the emergence of Lbx1(+) neurons, [RefSeq, PubMed]; Required for oligodendrocyte and motor neuron specification in the spinal cord., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90XC8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0071837 HMG box domain binding;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042552 myelination;GO:0061564 axon development;GO:0021778 oligodendrocyte cell fate specification", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q90XB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70082-1", "uniprot_id": [ { "id": "H2AJ_CHICK", "url": "https://www.uniprot.org/uniprot/P70082", "type": "external" } ], "mass": 14016.0, "length": 129, "protein_name": "Histone H2A.J", "gene_name": "H2A-IX; H2AC39", "organism": "Chicken", "refseq_name": "histone H2A.J", "refseq_ac": [ { "id": "NP_001025924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025924", "type": "external" } ], "gene_names_uniprotkb": "H2A-IX; H2AC39", "gene_names_refseq": "2A-IX; H2A-IX; H2AC39; H2AFJ; H2AJ; HIST1H2A9", "protein_names_uniprotkb": "Histone H2A.J; H2a/j; Histone H2A-IX", "protein_names_refseq": "H2A histone family, member J; H2a/j; buforin I; histone H2A-IX; histone H2A.J; histone cluster 1, H2A, IX (similar to human histone cluster 2, class H2A genes)", "tax_id": 9031, "disease": "", "pathway": " (gga:417947); (R-GGA-212300); (R-GGA-2299718); (R-GGA-2559580); (R-GGA-427413); (R-GGA-5250924); (R-GGA-606279); (R-GGA-68616); (R-GGA-73728); (R-GGA-73772); (R-GGA-8936459); (R-GGA-9018519); (R-GGA-9764725); (R-GGA-9841922); (R-GGA-9843940); (R-GGA-9843970); (R-GGA-9909649); (R-GGA-9940951); (R-GGA-9943411); (R-GGA-9943962)", "pathway_count": 20, "publication_count": 2, "publication_id_list": "15546875;8804862", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: HAEL01007247.1, HAEK01130657.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Aug 8, 2005 this sequence version replaced XP_416188.1., [RefSeq]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Ubiquitination of H2A does not affect the positioning of the histone octamer in the nucleosome in either the absence or the presence of linker histones, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P70082-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QLQ9-1", "uniprot_id": [ { "id": "GLL10_CHICK", "url": "https://www.uniprot.org/uniprot/Q6QLQ9", "type": "external" } ], "mass": 7130.0, "length": 68, "protein_name": "Gallinacin-10", "gene_name": "AvBD10; GAL10", "organism": "Chicken", "refseq_name": "gallinacin-10 preproprotein", "refseq_ac": [ { "id": "NP_001001609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001609", "type": "external" } ], "gene_names_uniprotkb": "AvBD10; GAL10", "gene_names_refseq": "AvBD10; GAL 10; GAL10; Gal-8; Gal8; gal-10", "protein_names_uniprotkb": "Gallinacin-10; Beta-defensin 10; Gal-10; Gal-8; Gallinacin-8", "protein_names_refseq": "beta-defensin 10; gallinacin-10 preproprotein; gallinacin-10; gallinacin-8", "tax_id": 9031, "disease": "", "pathway": " (gga:414341)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15148642;15310403;17244739;36481712", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BG713066.1, BU122054.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000070.1., [RefSeq]; Has bactericidal activity., [UniProtKB]; Temporal expression of avian beta defensin 10 and cathelicidins in the yolk sac tissue of broiler and layer embryos., [RefSeq, PubMed]; The chicken genome encodes only beta-defensins. The 13 chicken beta-defensin genes are clustered densely within a 86-Kb distance on the chromosome 3q3.5-q3.7. The deduced peptides share the characteristic defensin motif. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa;GO:0050832 defense response to fungus;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6QLQ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09108-1", "uniprot_id": [ { "id": "SCF_CHICK", "url": "https://www.uniprot.org/uniprot/Q09108", "type": "external" } ], "mass": 32328.0, "length": 287, "protein_name": "Kit ligand", "gene_name": "KITLG", "organism": "Chicken", "refseq_name": "kit ligand isoform 1 precursor", "refseq_ac": [ { "id": "NP_990461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990461", "type": "external" } ], "gene_names_uniprotkb": "KITLG; SCF", "gene_names_refseq": "KITLG", "protein_names_uniprotkb": "Kit ligand; MGF; Mast cell growth factor; SCF; Stem cell factor; c-Kit ligand", "protein_names_refseq": "C-kit ligand; KIT ligand precursor form 1; KIT ligand precursor form 4; MGF; SCF; kit ligand isoform 1 precursor; mast cell growth factor; stem cell factor", "tax_id": 9031, "disease": "", "pathway": " (gga:396028); (R-GGA-1257604); (R-GGA-1433557); (R-GGA-1433559); (R-GGA-5673001); (R-GGA-6811558); (R-GGA-9856649)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "22382085;22885556;7684722", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.224323.1, D13516.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1., [RefSeq]; Epidermal SCF molecule may be involved in the chemotactic guidance mechanism of in vivo NCCs., [RefSeq, PubMed]; KL mRNA expression during follicle maturation in the domestic hen was characterized., [RefSeq, PubMed]; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005173 stem cell factor receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0045636 positive regulation of melanocyte differentiation;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q09108-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HZ96-1", "uniprot_id": [ { "id": "AT1B4_CHICK", "url": "https://www.uniprot.org/uniprot/Q2HZ96", "type": "external" } ], "mass": 36363.0, "length": 321, "protein_name": "Protein ATP1B4", "gene_name": "ATP1B4", "organism": "Chicken", "refseq_name": "protein ATP1B4", "refseq_ac": [ { "id": "NP_001038116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038116", "type": "external" } ], "gene_names_uniprotkb": "ATP1B4", "gene_names_refseq": "ATP1B4", "protein_names_uniprotkb": "Protein ATP1B4; X,K-ATPase subunit beta-m; X/potassium-transporting ATPase subunit beta-m", "protein_names_refseq": "ATPase, (Na+)/K+ transporting, beta 4 polypeptide; ATPase, Na+/K+ transporting, beta 4 polypeptide; X/potassium-transporting ATPase subunit beta-m; protein ATP1B4; x,K-ATPase subunit beta-m", "tax_id": 9031, "disease": "", "pathway": " (gga:422365); (R-GGA-2173795)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "17592128", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ358914.1, SRR12888538.243591.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992437 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000071.1. On Aug 29, 2006 this sequence version replaced XP_420337.1., [RefSeq]; Chicken ATP1B4 ortholog associates with Na,K-ATPase alpha subunits of the same or other species, prevents alpha-subunit degradation, and produces functional ion pumps at the cell surface, indicating that it is a genuine Na,K-ATPase subunit., [RefSeq, PubMed]; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005637 nuclear inner membrane;GO:0005890 sodium:potassium-exchanging ATPase complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2HZ96-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QGQ7-1", "uniprot_id": [ { "id": "BMAL2_CHICK", "url": "https://www.uniprot.org/uniprot/Q8QGQ7", "type": "external" } ], "mass": 69132.0, "length": 622, "protein_name": "Basic helix-loop-helix ARNT-like protein 2", "gene_name": "ARNTL2; BMAL2", "organism": "Chicken", "refseq_name": "basic helix-loop-helix ARNT-like protein 2", "refseq_ac": [ { "id": "NP_989464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989464", "type": "external" } ], "gene_names_uniprotkb": "ARNTL2; BMAL2; ARNTL2", "gene_names_refseq": "ARNTL2; BMAL2", "protein_names_uniprotkb": "Basic helix-loop-helix ARNT-like protein 2; Aryl hydrocarbon receptor nuclear translocator-like protein 2; Brain and muscle ARNT-like 2; cBMAL2", "protein_names_refseq": "aryl hydrocarbon receptor nuclear translocator-like protein 2; basic helix-loop-helix ARNT-like protein 2; brain and muscle ARNT-like 2; cBMAL2; transcription factor BMAL2", "tax_id": 9031, "disease": "", "pathway": " (gga:373925)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11554928;15891043", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF246958.1, SRR13267658.2234.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. [provided by RefSeq, Feb 2014]., [RefSeq]; Expression of Bmal2 gene is detected in chicken pineal gland as a functional component of circadian rhythm., [RefSeq, PubMed]; Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. The preferred binding motif for the CLOCK-BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking adenine nucleotide at the 3-prime end of the canonical 6-nucleotide E-box sequence. CLOCK specifically binds to the half-site 5'-CAC-3', while BMAL1 binds to the half-site 5'-GTGA-3'., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0034751 aryl hydrocarbon receptor complex;GO:0005667 transcription regulator complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0007623 circadian rhythm;GO:0042753 positive regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8QGQ7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21265-1", "uniprot_id": [ { "id": "PUR8_CHICK", "url": "https://www.uniprot.org/uniprot/P21265", "type": "external" } ], "mass": 54653.0, "length": 485, "protein_name": "Adenylosuccinate lyase", "gene_name": "ADSL", "organism": "Chicken", "refseq_name": "adenylosuccinate lyase", "refseq_ac": [ { "id": "NP_990860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990860", "type": "external" } ], "gene_names_uniprotkb": "ADSL", "gene_names_refseq": "ADSL; purB", "protein_names_uniprotkb": "Adenylosuccinate lyase; 4.3.2.2; ADSL; ASL; ASase; Adenylosuccinase", "protein_names_refseq": "ASL; ASase; adenylosuccinase; adenylosuccinate lyase; adenysuccinate lyase", "tax_id": 9031, "disease": "", "pathway": " (gga:396540); (R-GGA-419140); (R-GGA-421203); (R-GGA-73817)", "pathway_count": 4, "publication_count": 10, "publication_id_list": "11323713;11572089;17224163;21058063;2111814;2123487;2147474;25867349;31111951;4726295", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M37901.1, AY786590.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Nov 27, 2021 this sequence version replaced NP_990860.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; A significant association between the MC4R genotype and body weight at 2, 4, and 10 wk of age was detected. Chickens possessing the BB genotype of CAPN1 showed significantly heavier body weight at 6 wk of age and guanine content at 4 wk of age, compared with those of the other genotypes. In addition, high expression levels of the CAPN1 and ADSL genes were detected in the breast muscle at 2 wk of age., [RefSeq, PubMed]; A single nucleotide polymorphism in exon 2 of the ADSL gene had an effect on inosine 5'-monophosphate content., [RefSeq, PubMed]; Authors...analyzed polymorphisms in the ADSL and LPL genes using the high-resolution melting curve method. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7UEA6;Q6BCQ1", "ec_number_list": [ { "id": "4.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.2", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity;GO:0070626 (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity;GO:0016829 lyase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006177 GMP biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process;GO:0044208 'de novo' AMP biosynthetic process;GO:0097294 'de novo' XMP biosynthetic process;GO:0009152 purine ribonucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P21265-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19150-1", "uniprot_id": [ { "id": "GBRA1_CHICK", "url": "https://www.uniprot.org/uniprot/P19150", "type": "external" } ], "mass": 51842.0, "length": 455, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-1", "gene_name": "GABRA1", "organism": "Chicken", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-1 precursor", "refseq_ac": [ { "id": "NP_989649", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989649", "type": "external" } ], "gene_names_uniprotkb": "GABRA1", "gene_names_refseq": "GABRA1", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-1; GABA(A) receptor subunit alpha-1; GABAAR subunit alpha-1", "protein_names_refseq": "GABA(A) receptor subunit alpha-1; GABAAR subunit alpha-1; gamma-aminobutyric acid (GABA) A receptor, alpha 1; gamma-aminobutyric acid receptor subunit alpha-1 precursor; gamma-aminobutyric acid receptor subunit alpha-1", "tax_id": 9031, "disease": "", "pathway": " (gga:374214); (R-GGA-977443)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1710013;17638299;22605922;24733046", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). The GABAARs can also initiate the formation of functional inhibitory GABAergic synapses (By similarity). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Chick cornea possesses alpha1 GABA-A, and rho1 GABA-C receptors, but not GABA-B receptors., [RefSeq, PubMed]; GABAA receptor blockade has a role in synaptic scaling through chloride accumulation in embryonic spinal motoneurons and interneurons Publication Status: Online-Only, [RefSeq, PubMed]; Our results show that 1 hr of normobaric acute hypoxia significantly changes the subunit mRNA levels. Different subunit mRNAs display different sensitivity to hypoxia: alpha(1), beta(2), and gamma(2) mRNAs are highly sensitive., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex;GO:0099634 postsynaptic specialization membrane", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P19150-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P10157-1", "uniprot_id": [ { "id": "ETS2_CHICK", "url": "https://www.uniprot.org/uniprot/P10157", "type": "external" } ], "mass": 54540.0, "length": 479, "protein_name": "Protein C-ets-2", "gene_name": "ETS2", "organism": "Chicken", "refseq_name": "protein C-ets-2", "refseq_ac": [ { "id": "NP_990643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990643", "type": "external" } ], "gene_names_uniprotkb": "ETS2", "gene_names_refseq": "ETS2; c-ets-2", "protein_names_uniprotkb": "Protein C-ets-2", "protein_names_refseq": "protein C-ets-2; v-ets avian erythroblastosis virus E26 oncogene homolog 2", "tax_id": 9031, "disease": "", "pathway": " (gga:396250); (R-GGA-2559585)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "3293999", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267654.226911.1, SRR13267658.20792.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000020.1., [RefSeq]; Probable transcription factor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001569 branching involved in blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P10157-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3L254-1", "uniprot_id": [ { "id": "WNT7B_CHICK", "url": "https://www.uniprot.org/uniprot/Q3L254", "type": "external" } ], "mass": 39530.0, "length": 349, "protein_name": "Protein Wnt-7b", "gene_name": "WNT7B", "organism": "Chicken", "refseq_name": "protein Wnt-7b isoform 1 precursor", "refseq_ac": [ { "id": "NP_001032351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032351", "type": "external" } ], "gene_names_uniprotkb": "WNT7B", "gene_names_refseq": "WNT7B", "protein_names_uniprotkb": "Protein Wnt-7b", "protein_names_refseq": "protein Wnt-7b isoform 1 precursor; protein Wnt-7b; wingless-type MMTV integration site family, member 7B", "tax_id": 9031, "disease": "", "pathway": " (gga:427937); (R-GGA-3238698)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16258938;7577679", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.249807.1, SRR13267652.25932.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Nov 23, 2005 this sequence version replaced XP_425509.1. Transcript Variant: This variant (1) differs in the 5' UTR and coding region compared to variant 2. This difference causes translation initiation at an upstream AUG and results in a protein (isoform 1) with a shorter and distinct N-terminus compared to isoform 2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Studied Wnt7b expression patterns in chick embryo nervous system, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3L253", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0071300 cellular response to retinoic acid;GO:0030182 neuron differentiation;GO:0060070 canonical Wnt signaling pathway;GO:0048144 fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q3L254-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49288-1", "uniprot_id": [ { "id": "MTR1C_CHICK", "url": "https://www.uniprot.org/uniprot/P49288", "type": "external" } ], "mass": 38576.0, "length": 346, "protein_name": "Melatonin receptor type 1C", "gene_name": "GPR50", "organism": "Chicken", "refseq_name": "melatonin receptor type 1C", "refseq_ac": [ { "id": "NP_990692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990692", "type": "external" } ], "gene_names_uniprotkb": "GPR50", "gene_names_refseq": "GPR50; Mel1c", "protein_names_uniprotkb": "Melatonin receptor type 1C; CKB; Mel-1C-R; Mel1c receptor", "protein_names_refseq": "CKB; Mel-1c melatonin receptor; mel-1C-R; mel1c receptor; melatonin receptor type 1C", "tax_id": 9031, "disease": "", "pathway": " (gga:396318)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24209505;27128575;7576645", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U31821.1, SRR13267649.107549.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000071.1., [RefSeq]; High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results suggest that melatonin mediates green light-induced bursal B-lymphocyte proliferation through melatonin receptor subrypes Mel1c and Mel1a receptors but not Mel1b receptors by activating the cyclic AMP/protein kinase A pathway, [RefSeq, PubMed]; These findings demonstrated that MEL mediated the monochromatic light-induced secretion of IGF-1 in chicks' livers by Mel1c and that Mel1a may be involved in this process., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008502 melatonin receptor activity;GO:1904408 melatonin binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0045820 negative regulation of glycolytic process;GO:0046325 negative regulation of D-glucose import", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P49288-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJW4-1", "uniprot_id": [ { "id": "SC22B_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJW4", "type": "external" } ], "mass": 24718.0, "length": 215, "protein_name": "Vesicle-trafficking protein SEC22b", "gene_name": "SEC22B", "organism": "Chicken", "refseq_name": "vesicle-trafficking protein SEC22b", "refseq_ac": [ { "id": "NP_001026437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026437", "type": "external" } ], "gene_names_uniprotkb": "SEC22B; RCJMB04_15c3", "gene_names_refseq": "SEC22B; SEC22L1", "protein_names_uniprotkb": "Vesicle-trafficking protein SEC22b; SEC22 vesicle-trafficking protein homolog B", "protein_names_refseq": "SEC22 vesicle trafficking protein-like 1; SEC22 vesicle-trafficking protein homolog B; vesicle-trafficking protein SEC22b", "tax_id": 9031, "disease": "", "pathway": " (gga:424377)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01023932.1, AJ720320.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000237.1. On Aug 8, 2005 this sequence version replaced XP_422221.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042470 melanosome;GO:0012507 ER to Golgi transport vesicle membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:1902902 negative regulation of autophagosome assembly;GO:0015031 protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0045732 positive regulation of protein catabolic process;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJW4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKC9-1", "uniprot_id": [ { "id": "1433Z_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKC9", "type": "external" } ], "mass": 27775.0, "length": 245, "protein_name": "14-3-3 protein zeta", "gene_name": "YWHAZ", "organism": "Chicken", "refseq_name": "14-3-3 protein zeta", "refseq_ac": [ { "id": "NP_001026514", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026514", "type": "external" } ], "gene_names_uniprotkb": "YWHAZ; RCJMB04_11l21", "gene_names_refseq": "14-3-3zeta; YWHAZ", "protein_names_uniprotkb": "14-3-3 protein zeta", "protein_names_refseq": "14-3-3 protein zeta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide", "tax_id": 9031, "disease": "", "pathway": " (gga:425619); (R-GGA-3769402); (R-GGA-392517); (R-GGA-430116); (R-GGA-512988); (R-GGA-5628897); (R-GGA-9614399)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "15642098;29652844", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01003976.1, AJ720155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN06143078 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000044.1. On Aug 8, 2005 this sequence version replaced XP_423359.1., [RefSeq]; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner., [UniProtKB, UniProtKB]; Results demonstrate that gga-miR-451 negatively regulates the Mycoplasma gallisepticum-induced production of inflammatory cytokines via targeting YWHAZ, inhibits the cell cycle progression and cell proliferation, and promotes cell apoptosis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0003016 respiratory system process;GO:0007165 signal transduction;GO:1900181 negative regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZKC9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51890-1", "uniprot_id": [ { "id": "LUM_CHICK", "url": "https://www.uniprot.org/uniprot/P51890", "type": "external" } ], "mass": 38642.0, "length": 343, "protein_name": "Lumican", "gene_name": "LUM", "organism": "Chicken", "refseq_name": "lumican precursor", "refseq_ac": [ { "id": "NP_001263286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263286", "type": "external" } ], "gene_names_uniprotkb": "LUM; LDC", "gene_names_refseq": "LDC; LUM", "protein_names_uniprotkb": "Lumican; KSPG lumican; Keratan sulfate proteoglycan lumican", "protein_names_refseq": "KSPG lumican; keratan sulfate proteoglycan lumican; lumican precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:417891); (R-GGA-2022854); (R-GGA-2022857); (R-GGA-216083)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "1370446;9545293", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01000545.1, M80584.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Feb 2, 2013 this sequence version replaced XP_416135.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. The genomic coordinates used for the transcript record were based on AF043111.1 and PubMed ID: 9565663., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005583 fibrillar collagen trimer", "go_biological_process": "GO:0032914 positive regulation of transforming growth factor beta1 production", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P51890-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90827-1", "uniprot_id": [ { "id": "NEL_CHICK", "url": "https://www.uniprot.org/uniprot/Q90827", "type": "external" } ], "mass": 90969.0, "length": 816, "protein_name": "Protein NEL", "gene_name": "NELL2; NEL", "organism": "Chicken", "refseq_name": "protein NEL precursor", "refseq_ac": [ { "id": "NP_001025911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025911", "type": "external" } ], "gene_names_uniprotkb": "NELL2; NEL", "gene_names_refseq": "NELL2; nel", "protein_names_uniprotkb": "Protein NEL; 93 kDa protein", "protein_names_refseq": "93 kDa protein; Mr 93 K protein; protein NEL precursor; protein NEL", "tax_id": 9031, "disease": "", "pathway": " (gga:417799)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15183717;22157752;7655083", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D86747.1, SRR13267655.24646.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. On Aug 8, 2005 this sequence version replaced XP_416042.1., [RefSeq]; NELL2 acts cell autonomously within CNS and PNS progenitors to promote their differentiation into neurons, and neuron-secreted NELL2 acts paracrinely to stimulate the mitogenesis of adjacent cells within the nascent dorsal root ganglion., [RefSeq, PubMed]; Nel interacts with a range of molecules through its different domains and exerts distinct functions., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0042802 identical protein binding;GO:0005080 protein kinase C binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0090260 negative regulation of retinal ganglion cell axon guidance;GO:0008283 cell population proliferation;GO:0009566 fertilization;GO:0045666 positive regulation of neuron differentiation;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q90827-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZLK5-1", "uniprot_id": [ { "id": "P4HA2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZLK5", "type": "external" } ], "mass": 61435.0, "length": 534, "protein_name": "Prolyl 4-hydroxylase subunit alpha-2", "gene_name": "P4HA2", "organism": "Chicken", "refseq_name": "prolyl 4-hydroxylase subunit alpha-2 precursor", "refseq_ac": [ { "id": "NP_001006155", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006155", "type": "external" } ], "gene_names_uniprotkb": "P4HA2; RCJMB04_5l17", "gene_names_refseq": "P4HA2", "protein_names_uniprotkb": "Prolyl 4-hydroxylase subunit alpha-2; 1.14.11.2; 4-PH alpha-2; Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2", "protein_names_refseq": "4-PH alpha-2; procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II; procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2; prolyl 4-hydroxylase alpha-2 subunit; prolyl 4-hydroxylase subunit alpha-2 precursor; prolyl 4-hydroxylase, alpha polypeptide II", "tax_id": 9031, "disease": "", "pathway": " (gga:416326)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;9211872", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719729.1, SRR13267655.245056.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ719729.1. On Jan 13, 2005 this sequence version replaced XP_414642.1., [RefSeq]; Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.2", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0031418 L-ascorbic acid binding;GO:0004656 procollagen-proline 4-dioxygenase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZLK5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15988-1", "uniprot_id": [ { "id": "CO6A2_CHICK", "url": "https://www.uniprot.org/uniprot/P15988", "type": "external" } ], "mass": 109177.0, "length": 1022, "protein_name": "Collagen alpha-2(VI) chain", "gene_name": "COL6A2", "organism": "Chicken", "refseq_name": "collagen alpha-2(VI) chain precursor", "refseq_ac": [ { "id": "NP_990679", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990679", "type": "external" } ], "gene_names_uniprotkb": "COL6A2", "gene_names_refseq": "COL6A2; colVIA2", "protein_names_uniprotkb": "Collagen alpha-2(VI) chain", "protein_names_refseq": "alpha 2(VI) collagen; collagen alpha-2(VI) chain precursor; collagen alpha-2(VI) chain; collagen, type VI, alpha 2; type VI collagen alpha-2 subunit; type VI collagen subunit alpha2", "tax_id": 9031, "disease": "", "pathway": " (gga:396292); (R-GGA-1650814)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "2011522;2015818;2351679;2491845;2787244", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X15041.1, SRR13267656.14965.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000235.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains because no single transcript from the same strain was available for the full length of the gene.The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Collagen VI acts as a cell-binding protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 5, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "Q6LEJ6;Q90583;Q90604", "ec_number_list": [], "go_molecular_function": "GO:0005518 collagen binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005576 extracellular region;GO:0042383 sarcolemma;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P15988-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "H9L0D7-1", "uniprot_id": [ { "id": "H9L0D7_CHICK", "url": "https://www.uniprot.org/uniprot/H9L0D7", "type": "external" } ], "mass": 54485.0, "length": 500, "protein_name": "Wiskott-Aldrich syndrome protein family member", "gene_name": "WASF2", "organism": "Chicken", "refseq_name": "wiskott-Aldrich syndrome protein family member 2", "refseq_ac": [ { "id": "XP_015153080", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015153080", "type": "external" } ], "gene_names_uniprotkb": "WASF2", "gene_names_refseq": "WASF2", "protein_names_uniprotkb": "Wiskott-Aldrich syndrome protein family member; WASP family protein member", "protein_names_refseq": "wiskott-Aldrich syndrome protein family member 2", "tax_id": 9031, "disease": "", "pathway": " (gga:426359); (R-GGA-2029482); (R-GGA-4420097); (R-GGA-5663213); (R-GGA-9013149); (R-GGA-9013404); (R-GGA-9013423)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052554.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005769 early endosome;GO:0005911 cell-cell junction;GO:0030027 lamellipodium;GO:0045202 synapse", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0098974 postsynaptic actin cytoskeleton organization;GO:0010592 positive regulation of lamellipodium assembly;GO:0051497 negative regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "H9L0D7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79996-1", "uniprot_id": [ { "id": "MK09_CHICK", "url": "https://www.uniprot.org/uniprot/P79996", "type": "external" } ], "mass": 44009.0, "length": 382, "protein_name": "Mitogen-activated protein kinase 9", "gene_name": "MAPK9", "organism": "Chicken", "refseq_name": "mitogen-activated protein kinase 9 isoform 1", "refseq_ac": [ { "id": "NP_990426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990426", "type": "external" } ], "gene_names_uniprotkb": "MAPK9; JNK2", "gene_names_refseq": "JNK2-ALPHA1; JNK2; MAPK9", "protein_names_uniprotkb": "Mitogen-activated protein kinase 9; 2.7.11.24; MAP kinase 9; MAPK 9; Stress-activated protein kinase JNK2; c-Jun N-terminal kinase 2", "protein_names_refseq": "MAP kinase 9; c-JUN amino-terminal kinase-2 alpha1; c-Jun N-terminal kinase 2; mitogen-activated protein kinase 9 isoform 1; stress-activated protein kinase JNK2", "tax_id": 9031, "disease": "", "pathway": " (gga:395983); (R-GGA-2559580); (R-GGA-2871796); (R-GGA-437986); (R-GGA-450321); (R-GGA-450341)", "pathway_count": 6, "publication_count": 11, "publication_id_list": "12193592;13130464;15837794;16186825;17875933;18793328;19661463;21968197;8533096;9177299;9195981", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB000807.1, SRR13267655.8334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000256.1., [RefSeq]; Inhibition of JNK1/2 leads to reduced viral progeny release, decreased viral transcription and lower virus protein expression; limiting apoptotic cell death as evidenced by blockage of Bax activation, cytochrome c release, and caspase activation, [RefSeq, PubMed]; RANKL inhibits VEGF-induced cell proliferation while causing increased expression of CtsK via calcineurin/NFATc1 and c-Jun N-terminal kinase (JNK)1/2-dependent signaling., [RefSeq, PubMed]; Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (By similarity). May play a role in the development of the central nervous system during embryogenesis. May play a role in the regulation of the circadian clock (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004705 JUN kinase activity;GO:0106310 protein serine kinase activity;GO:0004707 MAP kinase activity;GO:0004712 protein serine/threonine/tyrosine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0007254 JNK cascade;GO:0048511 rhythmic process;GO:0010744 positive regulation of macrophage derived foam cell differentiation;GO:0031398 positive regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P79996-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2VB19-1", "uniprot_id": [ { "id": "PUM1_CHICK", "url": "https://www.uniprot.org/uniprot/Q2VB19", "type": "external" } ], "mass": 126677.0, "length": 1189, "protein_name": "Pumilio homolog 1", "gene_name": "PUM1", "organism": "Chicken", "refseq_name": "pumilio homolog 1", "refseq_ac": [ { "id": "NP_001012858", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012858", "type": "external" } ], "gene_names_uniprotkb": "PUM1; RCJMB04_1f11", "gene_names_refseq": "PUM1", "protein_names_uniprotkb": "Pumilio homolog 1", "protein_names_refseq": "pumilio 1; pumilio homolog 1", "tax_id": 9031, "disease": "", "pathway": " (gga:419554); (R-GGA-432722)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15642098;17474090", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851393.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000339.1. On Sep 23, 2021 this sequence version replaced NP_001012858.1., [RefSeq]; Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q5F4A7", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0035198 miRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0005654 nucleoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0006417 regulation of translation;GO:0007283 spermatogenesis;GO:0008344 adult locomotory behavior;GO:0048863 stem cell differentiation;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2VB19-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19179-1", "uniprot_id": [ { "id": "PLSI_CHICK", "url": "https://www.uniprot.org/uniprot/P19179", "type": "external" } ], "mass": 70939.0, "length": 630, "protein_name": "Plastin-1", "gene_name": "PLS1", "organism": "Chicken", "refseq_name": "plastin-1", "refseq_ac": [ { "id": "NP_990678", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990678", "type": "external" } ], "gene_names_uniprotkb": "PLS1", "gene_names_refseq": "PLS1; plastin-1", "protein_names_uniprotkb": "Plastin-1; Fimbrin", "protein_names_refseq": "I-plastin; fimbrin; plastin-1", "tax_id": 9031, "disease": "", "pathway": " (gga:396291)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2391360", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X52562.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992428 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1., [RefSeq]; Actin-bundling protein. In the inner ear, it is required for stereocilia formation. Mediates liquid packing of actin filaments that is necessary for stereocilia to grow to their proper dimensions., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005903 brush border;GO:0032432 actin filament bundle;GO:0032420 stereocilium", "go_biological_process": "GO:0051017 actin filament bundle assembly;GO:0051639 actin filament network formation;GO:0001951 intestinal D-glucose absorption;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0040018 positive regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P19179-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NYI3-1", "uniprot_id": [ { "id": "F1NYI3_CHICK", "url": "https://www.uniprot.org/uniprot/F1NYI3", "type": "external" } ], "mass": 55242.0, "length": 505, "protein_name": "RNA-splicing ligase RtcB homolog", "gene_name": "RTCB", "organism": "Chicken", "refseq_name": "RNA-splicing ligase RtcB homolog", "refseq_ac": [ { "id": "XP_416300", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_416300", "type": "external" } ], "gene_names_uniprotkb": "RTCB", "gene_names_refseq": "RTCB", "protein_names_uniprotkb": "RNA-splicing ligase RtcB homolog; 3'-phosphate/5'-hydroxy nucleic acid ligase; 6.5.1.8", "protein_names_refseq": "RNA-splicing ligase RtcB homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:418064)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_416300.1. COMPLETENESS: full length., [RefSeq]; Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.5.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.8", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0170057 RNA ligase (GTP) activity;GO:0017166 vinculin binding;GO:0044600 protein guanylyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0072669 tRNA-splicing ligase complex;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0070054 mRNA splicing, via endonucleolytic cleavage and ligation;GO:0036498 IRE1-mediated unfolded protein response;GO:0000968 tRNA exon ligation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NYI3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NWP9-1", "uniprot_id": [ { "id": "F1NWP9_CHICK", "url": "https://www.uniprot.org/uniprot/F1NWP9", "type": "external" } ], "mass": 27592.0, "length": 245, "protein_name": "Fibroblast growth factor", "gene_name": "FGF13", "organism": "Chicken", "refseq_name": "fibroblast growth factor 13 isoform X2", "refseq_ac": [ { "id": "XP_015133693", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015133693", "type": "external" } ], "gene_names_uniprotkb": "FGF13", "gene_names_refseq": "FGF13; FHF-2", "protein_names_uniprotkb": "Fibroblast growth factor; FGF", "protein_names_refseq": "fibroblast growth factor 13 isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0008017 microtubule binding;GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0030425 dendrite", "go_biological_process": "GO:0030154 cell differentiation;GO:0051781 positive regulation of cell division;GO:0046785 microtubule polymerization;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NWP9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PU41-1", "uniprot_id": [ { "id": "CCKN_CHICK", "url": "https://www.uniprot.org/uniprot/Q9PU41", "type": "external" } ], "mass": 14091.0, "length": 130, "protein_name": "Cholecystokinin", "gene_name": "CCK", "organism": "Chicken", "refseq_name": "cholecystokinin precursor", "refseq_ac": [ { "id": "NP_001001741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001741", "type": "external" } ], "gene_names_uniprotkb": "CCK", "gene_names_refseq": "CCK", "protein_names_uniprotkb": "Cholecystokinin; CCK", "protein_names_refseq": "cholecystokinin precursor; preprocholecystokinin", "tax_id": 9031, "disease": "", "pathway": " (gga:414884); (R-GGA-375276); (R-GGA-416476)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "10069039;11072120;20376668;24440787;3620999;8355559;8637413;9039026", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CN210803.1, CN210802.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMN03376187 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000037.1. On Aug 30, 2004 this sequence version replaced XP_418814.1., [RefSeq]; CCK mRNA was expressed in neurons of the entire mesopallium, but not in any part of the nidopallium, [RefSeq, PubMed]; Mice treated with CCK at different doses display much delayed onset of collagen-induced arthritis and significantly lower incidence and decreased joint severity., [RefSeq, PubMed]; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030424 axon;GO:0005576 extracellular region", "go_biological_process": "GO:0007409 axonogenesis;GO:0001764 neuron migration;GO:0007586 digestion;GO:0038188 cholecystokinin signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9PU41-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F480-1", "uniprot_id": [ { "id": "ITPK1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F480", "type": "external" } ], "mass": 45316.0, "length": 407, "protein_name": "Inositol-tetrakisphosphate 1-kinase", "gene_name": "ITPK1", "organism": "Chicken", "refseq_name": "inositol-tetrakisphosphate 1-kinase", "refseq_ac": [ { "id": "NP_001012606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012606", "type": "external" } ], "gene_names_uniprotkb": "ITPK1; RCJMB04_2g4", "gene_names_refseq": "ITPK1", "protein_names_uniprotkb": "Inositol-tetrakisphosphate 1-kinase; 2.7.1.134; 2.7.1.159; Inositol 1,3,4-trisphosphate 5/6-kinase; Inositol-triphosphate 5/6-kinase; Ins(1,3,4)P(3) 5/6-kinase", "protein_names_refseq": "inositol 1,3,4-triphosphate 5/6 kinase; inositol 1,3,4-trisphosphate 5/6-kinase; inositol-tetrakisphosphate 1-kinase; inositol-triphosphate 5/6-kinase; ins(1,3,4)P(3) 5/6-kinase", "tax_id": 9031, "disease": "", "pathway": " (gga:423421); (R-GGA-1855167); (R-GGA-1855204); (R-GGA-983231)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851420.1, SRR13267654.79491.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000215.1. On Feb 28, 2005 this sequence version replaced XP_421331.1., [RefSeq]; Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.134", "type": "external" }, { "id": "2.7.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.159", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" } ], "go_molecular_function": "GO:0047325 inositol-3,4,5,6-tetrakisphosphate 1-kinase activity;GO:0052725 inositol-1,3,4-trisphosphate 6-kinase activity;GO:0052726 inositol-1,3,4-trisphosphate 5-kinase activity;GO:0052835 inositol-3,4,6-trisphosphate 1-kinase activity;GO:0000287 magnesium ion binding", "go_cellular_component": "", "go_biological_process": "GO:0070266 necroptotic process;GO:0032957 inositol trisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F480-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZM36-1", "uniprot_id": [ { "id": "IF4A3_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZM36", "type": "external" } ], "mass": 46816.0, "length": 412, "protein_name": "Eukaryotic initiation factor 4A-III", "gene_name": "EIF4A3", "organism": "Chicken", "refseq_name": "eukaryotic initiation factor 4A-III", "refseq_ac": [ { "id": "NP_001025820", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025820", "type": "external" } ], "gene_names_uniprotkb": "EIF4A3; DDX48; RCJMB04_3e17", "gene_names_refseq": "DDX48; EIF4A3; eIF4A-III", "protein_names_uniprotkb": "Eukaryotic initiation factor 4A-III; 3.6.4.13; ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD box protein 48; Eukaryotic translation initiation factor 4A isoform 3; eIF-4A-III; eIF4A-III", "protein_names_refseq": "ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; DEAD box protein 48; eIF-4A-III; eukaryotic initiation factor 4A-III", "tax_id": 9031, "disease": "", "pathway": " (gga:416704); (R-GGA-159236); (R-GGA-429947); (R-GGA-72163); (R-GGA-975957)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719548.1, HAEK01000552.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000062.1. On Aug 8, 2005 this sequence version replaced XP_415000.1., [RefSeq]; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006417 regulation of translation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000398 mRNA splicing, via spliceosome;GO:0051028 mRNA transport;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZM36-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02588-1", "uniprot_id": [ { "id": "TNNC2_CHICK", "url": "https://www.uniprot.org/uniprot/P02588", "type": "external" } ], "mass": 18375.0, "length": 163, "protein_name": "Troponin C, skeletal muscle", "gene_name": "TNNC2", "organism": "Chicken", "refseq_name": "troponin C, skeletal muscle", "refseq_ac": [ { "id": "NP_990781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990781", "type": "external" } ], "gene_names_uniprotkb": "TNNC2", "gene_names_refseq": "TNNC2", "protein_names_uniprotkb": "Troponin C, skeletal muscle", "protein_names_refseq": "troponin C (TNC); troponin C type 2 (fast); troponin C, skeletal muscle", "tax_id": 9031, "disease": "", "pathway": " (gga:396434); (R-GGA-390522)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "10231519;1390738;15299475;16213185;18942859;1908459;22579625;2963002;3338985;3969570;8519752;9367759;992069", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01010446.1, M19027.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992437 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000328.1. On Sep 23, 2021 this sequence version replaced NP_990781.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A model of the orientation of the C-terminal lobe of troponin C (TnC) in skeletal muscle., [RefSeq, PubMed]; Data show that a recombinant troponin C/calmodulin chimera, in which the carboxyl-terminal domain of TnC is replaced by that of CaM, has the same ability as CaM to bind and transmit the signal to calcium sites on the enzyme., [RefSeq, PubMed]; Fast pressure jumps can perturb calcium and magnesium binding to troponin C F29W.(, [RefSeq, PubMed]; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005861 troponin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0006937 regulation of muscle contraction", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P02588-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76LW2-1", "uniprot_id": [ { "id": "H6ST2_CHICK", "url": "https://www.uniprot.org/uniprot/Q76LW2", "type": "external" } ], "mass": 47175.0, "length": 403, "protein_name": "Heparan-sulfate 6-O-sulfotransferase 2", "gene_name": "HS6ST2", "organism": "Chicken", "refseq_name": "heparan-sulfate 6-O-sulfotransferase 2", "refseq_ac": [ { "id": "NP_989821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989821", "type": "external" } ], "gene_names_uniprotkb": "HS6ST2; RCJMB04_19a20", "gene_names_refseq": "HS6ST-2; HS6ST2", "protein_names_uniprotkb": "Heparan-sulfate 6-O-sulfotransferase 2; 2.8.2.-; HS6ST-2; cHS6ST-2", "protein_names_refseq": "cHS6ST-2; heparan-sulfate 6-O-sulfotransferase 2", "tax_id": 9031, "disease": "", "pathway": " (gga:395150); (R-GGA-2022928)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "14660620;15642098;20039926", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB071190.1, SRR13267659.23207.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000071.1., [RefSeq]; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate (By similarity). May also play a role in limb development., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Study showed that one heparan sulfate 2-O-sulfotransferase (HS2ST) and two isoforms of heparan sulfate 6-O-sulfotransferase (HS6ST-1 and -2) occurred in chick embryos and showed where the transcripts were distributed throughout the limb bud, [RefSeq, PubMed]; The chick HS6ST-2 transcripts is preferentially localized in the anterior and posterior proximal regions of the limb buds, respectively., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZJE1", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0017095 heparan sulfate 6-sulfotransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0060173 limb development;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q76LW2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F398-1", "uniprot_id": [ { "id": "MAEA_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F398", "type": "external" } ], "mass": 45388.0, "length": 396, "protein_name": "E3 ubiquitin-protein transferase MAEA", "gene_name": "MAEA", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein transferase MAEA", "refseq_ac": [ { "id": "NP_001012622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012622", "type": "external" } ], "gene_names_uniprotkb": "MAEA; RCJMB04_26n5", "gene_names_refseq": "MAEA", "protein_names_uniprotkb": "E3 ubiquitin-protein transferase MAEA; 2.3.2.27; Macrophage erythroblast attacher", "protein_names_refseq": "E3 ubiquitin-protein transferase MAEA; macrophage erythroblast attacher", "tax_id": 9031, "disease": "", "pathway": " (gga:426024); (R-GGA-9861718)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851752.1, HAEK01067900.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000074.1. On Feb 28, 2005 this sequence version replaced XP_423702.1., [RefSeq]; Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. MAEA is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (By similarity). Plays a role in erythroblast maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (By similarity). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005886 plasma membrane", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0007155 cell adhesion;GO:0051301 cell division;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0033033 negative regulation of myeloid cell apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F398-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90980-1", "uniprot_id": [ { "id": "CNG3_CHICK", "url": "https://www.uniprot.org/uniprot/Q90980", "type": "external" } ], "mass": 74779.0, "length": 645, "protein_name": "Cyclic nucleotide-gated channel rod photoreceptor subunit alpha", "gene_name": "CNGA1", "organism": "Chicken", "refseq_name": "cyclic nucleotide-gated channel rod photoreceptor subunit alpha", "refseq_ac": [ { "id": "NP_990551", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990551", "type": "external" } ], "gene_names_uniprotkb": "CNGA1", "gene_names_refseq": "CNGA1", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel rod photoreceptor subunit alpha; CNG channel 3; CNG-3; CNG3", "protein_names_refseq": "CNG channel 3; CNG-3; CNG3; alpha subunit of rod photoreceptor CNG-channel; cyclic nucleotide gated channel alpha 1; cyclic nucleotide-gated channel rod photoreceptor subunit alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:396143); (R-GGA-2485179); (R-GGA-2514859)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "7684234", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X89599.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMN08016552 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1., [RefSeq]; Visual signal transduction is mediated by a G protein-coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0030552 cAMP binding;GO:0030553 cGMP binding;GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042622 photoreceptor outer segment membrane;GO:0017071 intracellular cyclic nucleotide activated cation channel complex;GO:0120200 rod photoreceptor outer segment;GO:0016020 membrane", "go_biological_process": "GO:0007601 visual perception;GO:0098655 monoatomic cation transmembrane transport;GO:0007606 sensory perception of chemical stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90980-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06637-1", "uniprot_id": [ { "id": "BFSP1_CHICK", "url": "https://www.uniprot.org/uniprot/Q06637", "type": "external" } ], "mass": 76105.0, "length": 657, "protein_name": "Filensin", "gene_name": "BFSP1", "organism": "Chicken", "refseq_name": "filensin", "refseq_ac": [ { "id": "NP_990482", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990482", "type": "external" } ], "gene_names_uniprotkb": "BFSP1", "gene_names_refseq": "BFSP1", "protein_names_uniprotkb": "Filensin; Beaded filament structural protein 1; CP95; Lens fiber cell beaded-filament structural protein CP 95", "protein_names_refseq": "CP95; beaded filament structural protein 1, filensin; filensin; lens fiber cell beaded-filament structural protein CP 95", "tax_id": 9031, "disease": "", "pathway": " (gga:396056)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7693735", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X72873.1, SRR13267649.19315.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000061.1., [RefSeq]; Required for the correct formation of lens intermediate filaments., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0005882 intermediate filament", "go_biological_process": "GO:0070307 lens fiber cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q06637-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25429-1", "uniprot_id": [ { "id": "BDNF_CHICK", "url": "https://www.uniprot.org/uniprot/P25429", "type": "external" } ], "mass": 27715.0, "length": 246, "protein_name": "Neurotrophic factor BDNF precursor form", "gene_name": "BDNF", "organism": "Chicken", "refseq_name": "neurotrophic factor BDNF precursor form isoform 2 precursor", "refseq_ac": [ { "id": "NP_001026787", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026787", "type": "external" } ], "gene_names_uniprotkb": "BDNF", "gene_names_refseq": "BDNF", "protein_names_uniprotkb": "Neurotrophic factor BDNF precursor form; Brain-derived neurotrophic factor; proBDNF", "protein_names_refseq": "neurotrophic factor BDNF precursor form isoform 2 precursor; neurotrophic factor BDNF precursor form; neurotrophic factor; pre-pro-brain-derived; proBDNF", "tax_id": 9031, "disease": "", "pathway": " (gga:396186); (R-GGA-1257604); (R-GGA-6811558); (R-GGA-9026527); (R-GGA-9028731); (R-GGA-9032759)", "pathway_count": 6, "publication_count": 10, "publication_id_list": "1457809;15080885;15128848;16611805;1906813;2025430;23094873;23396147;26404565;30488213", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01007323.1, SRR12888496.183610.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000212.1. On or before Dec 7, 2021 this sequence version replaced XP_040556651.1, XP_419645.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; BDNF released by preganglionic axons acts chemotactically on TrkB-positive sympathetic neurons, to pattern the developing peripheral nervous system. Publication Status: Online-Only, [RefSeq, PubMed]; Blockade of spontaneous retinal activity with tetrodotoxin, or the blockade of axonal transport with colchicine, both reversed the normal mismatch between retinal BDNF mRNA and protein., [RefSeq, PubMed]; Findings demonstrate roles for BDNF-induced, trk-dependent signaling in ciliary ganglion neurons, both in regulating expression of alpha7-nAChRs and in enhancing transmission at alpha3*-nAChR-mediated synapses, [RefSeq, PubMed]; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Prenatal sensory stimulation induces BDNF gene expression in the brain and potentiates the development of natural pattern recognition in newborn chicks., [RefSeq, PubMed]; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The stress resilient Production Reds showed stable BDNF levels across the isolation test period whereas the vulnerable Black Australorps showed an increase in hippocampal BDNF levels, [RefSeq, PubMed]; These results suggest that BDNF promotes the induction of imprinting through TrkB exclusively during the critical period., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q45N27", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0048812 neuron projection morphogenesis;GO:0043524 negative regulation of neuron apoptotic process;GO:0050804 modulation of chemical synaptic transmission;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P25429-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90687-1", "uniprot_id": [ { "id": "PTN11_CHICK", "url": "https://www.uniprot.org/uniprot/Q90687", "type": "external" } ], "mass": 67983.0, "length": 593, "protein_name": "Tyrosine-protein phosphatase non-receptor type 11", "gene_name": "PTPN11", "organism": "Chicken", "refseq_name": "tyrosine-protein phosphatase non-receptor type 11", "refseq_ac": [ { "id": "NP_990299", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990299", "type": "external" } ], "gene_names_uniprotkb": "PTPN11", "gene_names_refseq": "PTPN11; SYP", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 11; 3.1.3.48; SH-PTP2; cSH-PTP2", "protein_names_refseq": "SH-PTP2; cSH-PTP2; tyrosine-protein phosphatase non-receptor type 11", "tax_id": 9031, "disease": "", "pathway": " (gga:395815); (R-GGA-1059683); (R-GGA-109704); (R-GGA-1257604); (R-GGA-1433557); (R-GGA-180292); (R-GGA-186763); (R-GGA-210990); (R-GGA-210993); (R-GGA-389513); (R-GGA-389948); (R-GGA-432142); (R-GGA-512988); (R-GGA-5654689); (R-GGA-5654693); (R-GGA-5654695); (R-GGA-5654700); (R-GGA-5654706); (R-GGA-5654710); (R-GGA-5654712); (R-GGA-5654720); (R-GGA-5654726); (R-GGA-5654727); (R-GGA-5654732); (R-GGA-5654733); (R-GGA-6811558); (R-GGA-8853659); (R-GGA-8854691); (R-GGA-8865999); (R-GGA-8934593); (R-GGA-912694); (R-GGA-936964)", "pathway_count": 32, "publication_count": 2, "publication_id_list": "19433062;8921851", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U38620.1, HAEK01006151.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000260.1., [RefSeq]; These results suggest that SHP2-mediated tyrosine dephosphorylation is an important step in Sema4D-induced axon repulsion., [RefSeq, PubMed]; This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation (By similarity). The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation (PubMed:8921851)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" } ], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0030971 receptor tyrosine kinase binding;GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity;GO:0001784 phosphotyrosine residue binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:0038127 ERBB signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0071364 cellular response to epidermal growth factor stimulus;GO:0032331 negative regulation of chondrocyte differentiation;GO:0045778 positive regulation of ossification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90687-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1P0Z7-1", "uniprot_id": [ { "id": "F1P0Z7_CHICK", "url": "https://www.uniprot.org/uniprot/F1P0Z7", "type": "external" } ], "mass": 21509.0, "length": 186, "protein_name": "ARF like GTPase 8B", "gene_name": "ARL8B", "organism": "Chicken", "refseq_name": "ADP-ribosylation factor-like protein 8B isoform X1", "refseq_ac": [ { "id": "XP_414440", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_414440", "type": "external" } ], "gene_names_uniprotkb": "ARL8B", "gene_names_refseq": "ARL8B", "protein_names_uniprotkb": "ARF like GTPase 8B", "protein_names_refseq": "ADP-ribosylation factor-like protein 8B isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052543.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_414440.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005819 spindle;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0051301 cell division;GO:0008089 anterograde axonal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1P0Z7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QGW7-1", "uniprot_id": [ { "id": "LITAF_CHICK", "url": "https://www.uniprot.org/uniprot/Q8QGW7", "type": "external" } ], "mass": 16013.0, "length": 148, "protein_name": "Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog", "gene_name": "LITAF", "organism": "Chicken", "refseq_name": "lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog", "refseq_ac": [ { "id": "NP_989598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989598", "type": "external" } ], "gene_names_uniprotkb": "LITAF; SIMPLE", "gene_names_refseq": "LITAF; TNF-alpha", "protein_names_uniprotkb": "Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; LPS-induced TNF-alpha factor homolog; Small integral membrane protein of lysosome/late endosome", "protein_names_refseq": "LPS-induced TNF-alpha factor homolog; TNF-alpha factor; lipid-induced TNF-alpha factor; lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; small integral membrane protein of lysosome/late endosome; tissue necrosis factor-alpha; tumor necrosis factor-alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:374125)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "18539728;18612836;22270623;26276563;26899319;29719531", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01044512.1, ERR2365563.175125.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000257.1., [RefSeq]; Data show that IL-10, IFN-gamma and TNF-alpha contents in the cecal tonsil were significantly decreased in the 30, 45 and 60 mg/kg groups, while IL-6 content in the cecal tonsil was only decreased in 60 mg/kg at 14 and 28 days of age., [RefSeq, PubMed]; IL1B and LITAF mRNAs are increased in the vagina during insemination. This response may lead to sperm degradation and elimination., [RefSeq, PubMed]; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines., [UniProtKB, UniProtKB]; The expression of interleukin(IL)-1 beta, IL-6, and tumor necrosis factor (TNF)-alpha in amyoidosis arthropathy in chickens was studied., [RefSeq, PubMed]; The results showed that Se deficiency induced high expression levels of PTGE, COX-2, TNF-alpha, and NF-kappaB in the gastrointestinal tract tissues., [RefSeq, PubMed]; The results showed that the expression levels of IL-6, IL-8, TNF-alpha, and NF-kappaB which seemed to be a critical mediator in the inflammatory response tended to increase in the birds chronically treated with As2O3. However, the mRNA expression levels of IL-4, IL-12beta, and IL-1beta were decreased in the experiment., [RefSeq, PubMed]; This paper provides characterization of chicken tumor necrosis factor-alpha Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0005125 cytokine activity;GO:0042802 identical protein binding;GO:0050699 WW domain binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005765 lysosomal membrane;GO:0009898 cytoplasmic side of plasma membrane;GO:0098574 cytoplasmic side of lysosomal membrane", "go_biological_process": "GO:0019953 sexual reproduction;GO:0006351 DNA-templated transcription;GO:0001817 regulation of cytokine production;GO:0001816 cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q8QGW7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZMC9-1", "uniprot_id": [ { "id": "NDE1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZMC9", "type": "external" } ], "mass": 39564.0, "length": 342, "protein_name": "Nuclear distribution protein nudE homolog 1", "gene_name": "NDE1", "organism": "Chicken", "refseq_name": "nuclear distribution protein nudE homolog 1", "refseq_ac": [ { "id": "NP_001006169", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006169", "type": "external" } ], "gene_names_uniprotkb": "NDE1; RCJMB04_2i10", "gene_names_refseq": "NDE1", "protein_names_uniprotkb": "Nuclear distribution protein nudE homolog 1", "protein_names_refseq": "nuclear distribution protein nudE homolog 1; nudE nuclear distribution E homolog 1; nudE nuclear distribution gene E homolog 1", "tax_id": 9031, "disease": "", "pathway": " (gga:416597); (R-GGA-141430); (R-GGA-141444); (R-GGA-2467813); (R-GGA-2500257); (R-GGA-2565942); (R-GGA-380259); (R-GGA-380270); (R-GGA-380284); (R-GGA-380320); (R-GGA-5620912); (R-GGA-5663220); (R-GGA-8854518); (R-GGA-9648025)", "pathway_count": 14, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01000956.1, AJ719455.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000257.1. On Jan 13, 2005 this sequence version replaced XP_414897.1., [RefSeq]; Required for centrosome duplication and formation and function of the mitotic spindle., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0030659 cytoplasmic vesicle membrane;GO:0032154 cleavage furrow", "go_biological_process": "GO:0007059 chromosome segregation;GO:0016477 cell migration;GO:0051301 cell division;GO:0007020 microtubule nucleation;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZMC9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F3W3-1", "uniprot_id": [ { "id": "MK06_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F3W3", "type": "external" } ], "mass": 82747.0, "length": 721, "protein_name": "Mitogen-activated protein kinase 6", "gene_name": "MAPK4; MAPK6", "organism": "Chicken", "refseq_name": "mitogen-activated protein kinase 6", "refseq_ac": [ { "id": "NP_001025720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025720", "type": "external" } ], "gene_names_uniprotkb": "MAPK4; MAPK6; RCJMB04_5i17", "gene_names_refseq": "MAPK4; MAPK6", "protein_names_uniprotkb": "Mitogen-activated protein kinase 6; 2.7.11.24; MAP kinase 6; MAPK 6", "protein_names_refseq": "MAP kinase 6; MAPK 6; mitogen-activated protein kinase 6", "tax_id": 9031, "disease": "", "pathway": " (gga:415419); (R-GGA-5687128)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851537.1, SRR13267661.13728.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992692 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000245.1. On Aug 8, 2005 this sequence version replaced XP_413802.1., [RefSeq]; Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0004707 MAP kinase activity", "go_cellular_component": "GO:0032156 septin cytoskeleton;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F3W3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53478-1", "uniprot_id": [ { "id": "ACT5_CHICK", "url": "https://www.uniprot.org/uniprot/P53478", "type": "external" } ], "mass": 41836.0, "length": 376, "protein_name": "Actin, cytoplasmic type 5", "gene_name": "ACTG1L", "organism": "Chicken", "refseq_name": "actin, cytoplasmic type 5", "refseq_ac": [ { "id": "NP_001007825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007825", "type": "external" } ], "gene_names_uniprotkb": "ACTG1L", "gene_names_refseq": "ACTG1L", "protein_names_uniprotkb": "Actin, cytoplasmic type 5; 3.6.4.-", "protein_names_refseq": "actin, cytoplasmic 2; actin, cytoplasmic type 5; actin, cytoplasmic, type 5; actin, gamma 1 propeptide; cytoplasmic type 5; gamma-actin; type 5 nonmuscle actin", "tax_id": 9031, "disease": "", "pathway": " (gga:415296); (R-GGA-114608); (R-GGA-190873); (R-GGA-196025); (R-GGA-2029482); (R-GGA-3928662); (R-GGA-3928665); (R-GGA-418990); (R-GGA-437239); (R-GGA-4420097); (R-GGA-5626467); (R-GGA-5663213); (R-GGA-5663220); (R-GGA-5674135); (R-GGA-5689603); (R-GGA-5696394); (R-GGA-8856828); (R-GGA-9035034); (R-GGA-9764561); (R-GGA-9933937); (R-GGA-9933939); (R-GGA-9933946); (R-GGA-9933947); (R-GGA-9934037); (R-GGA-9953170); (R-GGA-9958825)", "pathway_count": 26, "publication_count": 2, "publication_id_list": "27775032;4000121", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01154857.1, HAEL01005232.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000245.1. On Dec 15, 2004 this sequence version replaced XP_413685.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells., [UniProtKB]; SAXS kinetic analysis indicated that G-actin tetramerization gives the highest energetic barrier to further polymerization. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0019901 protein kinase binding;GO:0098973 structural constituent of postsynaptic actin cytoskeleton", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0007409 axonogenesis;GO:0048870 cell motility", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P53478-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1P1U2-1", "uniprot_id": [ { "id": "F1P1U2_CHICK", "url": "https://www.uniprot.org/uniprot/F1P1U2", "type": "external" } ], "mass": 72960.0, "length": 660, "protein_name": "Tumor protein p73", "gene_name": "TP73", "organism": "Chicken", "refseq_name": "tumor protein p73 isoform X1", "refseq_ac": [ { "id": "XP_046759187", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046759187", "type": "external" } ], "gene_names_uniprotkb": "TP73", "gene_names_refseq": "TP73", "protein_names_uniprotkb": "Tumor protein p73", "protein_names_refseq": "tumor protein p73 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:419382); (R-GGA-6804759); (R-GGA-8939236)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052552.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046872 metal ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0051262 protein tetramerization;GO:0006915 apoptotic process;GO:1901248 positive regulation of lung ciliated cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1P1U2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17251-1", "uniprot_id": [ { "id": "PTHR_CHICK", "url": "https://www.uniprot.org/uniprot/P17251", "type": "external" } ], "mass": 20226.0, "length": 176, "protein_name": "Parathyroid hormone-related protein", "gene_name": "PTHLH", "organism": "Chicken", "refseq_name": "parathyroid hormone-related protein isoform 2 preproprotein", "refseq_ac": [ { "id": "NP_990669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990669", "type": "external" } ], "gene_names_uniprotkb": "PTHLH", "gene_names_refseq": "PTHLH; PTHrP", "protein_names_uniprotkb": "Parathyroid hormone-related protein; PTH-rP; PTHrP[107-139]; PTHrP", "protein_names_refseq": "PTH-rP; parathyroid hormone-related protein isoform 2 preproprotein; parathyroid hormone-related protein", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-373080); (R-GGA-418555)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10366729;2349111;26662056", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X52131.1, SRR12888498.248929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992440, SAMEA103992544 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Dec 3, 2021 this sequence version replaced NP_990669.2. Transcript Variant: This variant (2) has an alternate 3' sequence, as compared to variant 1. The resulting isoform (2) lacks the last two aa, as compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport (By similarity). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (By similarity). Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (By similarity). Required for skeletal homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Overexpression of Btg1 induced intense upregulation of PTHrP. In complementary knockdown experiments, this marker was regulated in an opposite fashion., [RefSeq, PubMed]; Potent inhibitor of osteoclastic bone resorption., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005615 extracellular space;GO:0005654 nucleoplasm", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0002076 osteoblast development;GO:0032330 regulation of chondrocyte differentiation;GO:0030282 bone mineralization;GO:0003420 regulation of growth plate cartilage chondrocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P17251-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22451-1", "uniprot_id": [ { "id": "RL5_CHICK", "url": "https://www.uniprot.org/uniprot/P22451", "type": "external" } ], "mass": 34091.0, "length": 297, "protein_name": "Large ribosomal subunit protein uL18", "gene_name": "RPL5", "organism": "Chicken", "refseq_name": "large ribosomal subunit protein uL18", "refseq_ac": [ { "id": "NP_989912", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989912", "type": "external" } ], "gene_names_uniprotkb": "RPL5", "gene_names_refseq": "RPL5", "protein_names_uniprotkb": "Large ribosomal subunit protein uL18; 60S ribosomal protein L5", "protein_names_refseq": "60S ribosomal protein L5; large ribosomal subunit protein uL18", "tax_id": 9031, "disease": "", "pathway": " (gga:395269); (R-GGA-1799339); (R-GGA-72706); (R-GGA-975956); (R-GGA-975957); (R-GGA-9954709); (R-GGA-9954714); (R-GGA-9954716)", "pathway_count": 8, "publication_count": 3, "publication_id_list": "1398102;1840495;7649987", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01003933.1, HAEK01082851.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000239.1., [RefSeq]; Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008097 5S rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0045202 synapse;GO:0022625 cytosolic large ribosomal subunit;GO:0022626 cytosolic ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000027 ribosomal large subunit assembly;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P22451-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NZ23-1", "uniprot_id": [ { "id": "F1NZ23_CHICK", "url": "https://www.uniprot.org/uniprot/F1NZ23", "type": "external" } ], "mass": 89062.0, "length": 780, "protein_name": "General transcription and DNA repair factor IIH helicase/translocase subunit XPB", "gene_name": "ERCC3", "organism": "Chicken", "refseq_name": "general transcription and DNA repair factor IIH helicase subunit XPB", "refseq_ac": [ { "id": "NP_001006523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006523", "type": "external" } ], "gene_names_uniprotkb": "ERCC3", "gene_names_refseq": "ERCC3", "protein_names_uniprotkb": "General transcription and DNA repair factor IIH helicase/translocase subunit XPB; 5.6.2.4; DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3", "protein_names_refseq": "DNA excision repair protein ERCC-3; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH subunit XPB; excision repair cross-complementation group 3; excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing); general transcription and DNA repair factor IIH helicase subunit XPB", "tax_id": 9031, "disease": "", "pathway": " (gga:424226); (R-GGA-5696395); (R-GGA-5696400); (R-GGA-674695); (R-GGA-6781823); (R-GGA-6782135); (R-GGA-6782210); (R-GGA-6796648); (R-GGA-72086); (R-GGA-73772); (R-GGA-73776); (R-GGA-73779); (R-GGA-73863); (R-GGA-75953); (R-GGA-75955); (R-GGA-76042); (R-GGA-77075)", "pathway_count": 17, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720077.1, SRR13267659.226911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000236.1. On Mar 15, 2015 this sequence version replaced NP_001006523.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0097550 transcription preinitiation complex;GO:0005675 transcription factor TFIIH holo complex;GO:0005669 transcription factor TFIID complex;GO:0000112 nucleotide-excision repair factor 3 complex", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006289 nucleotide-excision repair;GO:0006979 response to oxidative stress;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NZ23-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZMV3-1", "uniprot_id": [ { "id": "NC2B_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZMV3", "type": "external" } ], "mass": 19444.0, "length": 176, "protein_name": "Protein Dr1", "gene_name": "DR1", "organism": "Chicken", "refseq_name": "protein Dr1", "refseq_ac": [ { "id": "NP_001008478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008478", "type": "external" } ], "gene_names_uniprotkb": "DR1; RCJMB04_1b9", "gene_names_refseq": "DR1", "protein_names_uniprotkb": "Protein Dr1; Down-regulator of transcription 1; NC2-beta; Negative cofactor 2-beta; TATA-binding protein-associated phosphoprotein", "protein_names_refseq": "NC2-beta; TATA-binding protein-associated phosphoprotein; down-regulator of transcription 1, TBP-binding (negative cofactor 2); negative cofactor 2-beta; protein Dr1", "tax_id": 9031, "disease": "", "pathway": " (gga:424496)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719281.1, HAEK01039569.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000239.1. On Dec 16, 2004 this sequence version replaced XP_422336.1., [RefSeq]; The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0017025 TBP-class protein binding;GO:0016251 RNA polymerase II general transcription initiation factor activity;GO:0140223 general transcription initiation factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex;GO:0017054 negative cofactor 2 complex;GO:0140672 ATAC complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0051726 regulation of cell cycle;GO:0045995 regulation of embryonic development;GO:0051302 regulation of cell division;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZMV3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90888-1", "uniprot_id": [ { "id": "MAFB_CHICK", "url": "https://www.uniprot.org/uniprot/Q90888", "type": "external" } ], "mass": 35467.0, "length": 311, "protein_name": "Transcription factor MafB", "gene_name": "MAFB", "organism": "Chicken", "refseq_name": "transcription factor MafB", "refseq_ac": [ { "id": "NP_001026023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026023", "type": "external" } ], "gene_names_uniprotkb": "MAFB", "gene_names_refseq": "MAFB", "protein_names_uniprotkb": "Transcription factor MafB; Maf-B; V-maf musculoaponeurotic fibrosarcoma oncogene homolog B", "protein_names_refseq": "maf-B; transcription factor MafB; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B", "tax_id": 9031, "disease": "", "pathway": " (gga:419173)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11036080;12081646;25005477;34324991;7935473", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BU255994.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000328.1. On Aug 8, 2005 this sequence version replaced XP_417353.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha-A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE)., [UniProtKB, PubMed, PubMed]; Dimeric combinations of MafB, cFos and cJun in developing chick limb buds control the number of apoptotic cells., [RefSeq, PubMed]; Identification of regulatory elements for MafB expression in the cardiac neural crest., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0045637 regulation of myeloid cell differentiation;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q90888-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18908-1", "uniprot_id": [ { "id": "ANF_CHICK", "url": "https://www.uniprot.org/uniprot/P18908", "type": "external" } ], "mass": 15714.0, "length": 140, "protein_name": "Natriuretic peptides A", "gene_name": "NPPA", "organism": "Chicken", "refseq_name": "natriuretic peptides B precursor", "refseq_ac": [ { "id": "NP_990256", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990256", "type": "external" } ], "gene_names_uniprotkb": "NPPA", "gene_names_refseq": "ANF; ANP; NPPA; NPPB", "protein_names_uniprotkb": "Natriuretic peptides A; ANP; Atrial natriuretic peptide; Prepronatriodilatin", "protein_names_refseq": "atrial natriuretic factor; atrial natriuretic peptide; natriuretic peptide B; natriuretic peptide precursor A; natriuretic peptides A; natriuretic peptides B precursor; natriuretic peptides B; prepronatriodilatin", "tax_id": 9031, "disease": "", "pathway": " (gga:395765)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1826483;26463554;2972278", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X57702.1, BU143825.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051, SAMN00000795 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X57702.1., [RefSeq]; BNP stimulates the proliferation, differentiation, and lipolysis of preadipocytes through upregulation of the levels of expression of its receptor NPR1 and key genes enriched in the glycerolipid metabolic pathway., [RefSeq, PubMed]; Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0051427 hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005576 extracellular region", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0006182 cGMP biosynthetic process;GO:0007218 neuropeptide signaling pathway;GO:0097746 blood vessel diameter maintenance;GO:0003085 negative regulation of systemic arterial blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P18908-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02391-1", "uniprot_id": [ { "id": "GSLG1_CHICK", "url": "https://www.uniprot.org/uniprot/Q02391", "type": "external" } ], "mass": 129711.0, "length": 1142, "protein_name": "Golgi apparatus protein 1", "gene_name": "GLG1", "organism": "Chicken", "refseq_name": "Golgi apparatus protein 1 precursor", "refseq_ac": [ { "id": "NP_990827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990827", "type": "external" } ], "gene_names_uniprotkb": "GLG1; CFR", "gene_names_refseq": "CFR; GLG1", "protein_names_uniprotkb": "Golgi apparatus protein 1; Cysteine-rich fibroblast growth factor receptor", "protein_names_refseq": "Golgi apparatus protein 1 precursor; cysteine-rich fibroblast growth factor receptor; golgi apparatus protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:396492)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1448090;19285038;2553717;9066777", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M95766.1, SRR13267654.124233.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000247.1., [RefSeq]; Binds fibroblast growth factor and E-selectin (cell-adhesion lectin on endothelial cells mediating the binding of neutrophils) (By similarity). Binds fibroblast growth factor (FGF). May be involved in intracellular FGF trafficking and the regulation of cellular responses to FGFS (PubMed:1448090)., [UniProtKB, UniProtKB, PubMed]; Efficient secretion of CFR is depending on processing by furin-like proprotein convertases., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q91019", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0031012 extracellular matrix;GO:0005815 microtubule organizing center", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q02391-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F450-1", "uniprot_id": [ { "id": "PAN2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F450", "type": "external" } ], "mass": 134863.0, "length": 1197, "protein_name": "PAN2-PAN3 deadenylation complex catalytic subunit PAN2", "gene_name": "PAN2", "organism": "Chicken", "refseq_name": "PAN2-PAN3 deadenylation complex catalytic subunit PAN2", "refseq_ac": [ { "id": "NP_001012972", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012972", "type": "external" } ], "gene_names_uniprotkb": "PAN2; RCJMB04_3e13; USP52", "gene_names_refseq": "PAN2; USP52", "protein_names_uniprotkb": "PAN2-PAN3 deadenylation complex catalytic subunit PAN2; 3.1.13.4; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 2; Poly(A)-nuclease deadenylation complex subunit 2", "protein_names_refseq": "PAB-dependent poly(A)-specific ribonuclease subunit 2; PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 2; PAN2 poly(A) specific ribonuclease subunit homolog; PAN2 polyA specific ribonuclease subunit homolog; PAN2-PAN3 deadenylation complex catalytic subunit PAN2; poly(A) specific ribonuclease subunit PAN2; poly(A)-nuclease deadenylation complex subunit 2; ubiquitin specific peptidase 52; ubiquitin specific protease 52", "tax_id": 9031, "disease": "", "pathway": " (gga:429172); (R-GGA-429947)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851450.1, SRR13267649.85334.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000490.1. On Mar 14, 2005 this sequence version replaced XP_426727.1., [RefSeq]; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0031251 PAN complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly;GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F450-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7ZUA6-1", "uniprot_id": [ { "id": "LMBR1_CHICK", "url": "https://www.uniprot.org/uniprot/Q7ZUA6", "type": "external" } ], "mass": 55084.0, "length": 488, "protein_name": "Limb region 1 protein homolog", "gene_name": "LMBR1", "organism": "Chicken", "refseq_name": "limb region 1 protein homolog isoform X3", "refseq_ac": [ { "id": "XP_046766138", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046766138", "type": "external" } ], "gene_names_uniprotkb": "LMBR1; SAPH1", "gene_names_refseq": "ACHP; C7orf2; DIF14; LMBR1; LSS; PPD2; THYP; TPT; ZRS", "protein_names_uniprotkb": "Limb region 1 protein homolog", "protein_names_refseq": "limb region 1 protein homolog isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:373986)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14991708;16650944;21161408", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052574.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Putative membrane receptor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "B2CW63;E0W5S4;E0W5S5;E0W5S6;E0W5S7;Q7ZZZ1;Q90WF5", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q7ZUA6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QGH2-1", "uniprot_id": [ { "id": "SUMO1_CHICK", "url": "https://www.uniprot.org/uniprot/Q8QGH2", "type": "external" } ], "mass": 11557.0, "length": 101, "protein_name": "Small ubiquitin-related modifier 1", "gene_name": "SUMO1", "organism": "Chicken", "refseq_name": "small ubiquitin-related modifier 1", "refseq_ac": [ { "id": "NP_989466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989466", "type": "external" } ], "gene_names_uniprotkb": "SUMO1; RCJMB04_2j18", "gene_names_refseq": "DAP1; GMP1; OFC10; PIC1; SENP2; SMT3C; SMT3H3; SMT3; SUMO1; UBL1; sentrin", "protein_names_uniprotkb": "Small ubiquitin-related modifier 1; SUMO-1", "protein_names_refseq": "GAP modifying protein 1; SMT3 homolog 3; SMT3 suppressor of mif two 3 homolog 1; SUMO-1; small ubiquitin-related modifier 1; ubiquitin-homology domain protein PIC1; ubiquitin-like 1 (sentrin); ubiquitin-like protein SMT3C; ubiquitin-like protein UBL1", "tax_id": 9031, "disease": "", "pathway": " (gga:373930); (R-GGA-3065676); (R-GGA-3065678); (R-GGA-3065679); (R-GGA-3108214); (R-GGA-3232118); (R-GGA-3232142); (R-GGA-3899300); (R-GGA-4085377); (R-GGA-4090294); (R-GGA-4551638); (R-GGA-4570464); (R-GGA-4615885); (R-GGA-4655427); (R-GGA-4755510); (R-GGA-5693565); (R-GGA-5696395); (R-GGA-877312); (R-GGA-8866904); (R-GGA-9615933); (R-GGA-9793242); (R-GGA-9856649); (R-GGA-9937850)", "pathway_count": 23, "publication_count": 2, "publication_id_list": "15642098;25205350", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719470.1, DR413967.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ719470.1., [RefSeq]; RNF4, targeted by the small ubiquitin-like modifier (SUMO) for ubiquitin-mediated degradation, plays a novel role in preventing the loss of intact chromosomes and ensures the maintenance of chromosome integrity., [RefSeq, PubMed]; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044389 ubiquitin-like protein ligase binding;GO:0031386 protein tag activity", "go_cellular_component": "GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0016925 protein sumoylation;GO:0034605 cellular response to heat;GO:0071276 cellular response to cadmium ion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8QGH2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q76KB2-1", "uniprot_id": [ { "id": "H6ST1_CHICK", "url": "https://www.uniprot.org/uniprot/Q76KB2", "type": "external" } ], "mass": 48092.0, "length": 408, "protein_name": "Heparan-sulfate 6-O-sulfotransferase 1", "gene_name": "HS6ST1", "organism": "Chicken", "refseq_name": "heparan-sulfate 6-O-sulfotransferase 1", "refseq_ac": [ { "id": "NP_989813", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989813", "type": "external" } ], "gene_names_uniprotkb": "HS6ST1", "gene_names_refseq": "CHS6ST-1; HS6ST1", "protein_names_uniprotkb": "Heparan-sulfate 6-O-sulfotransferase 1; 2.8.2.-; HS6ST-1; cHS6ST-1", "protein_names_refseq": "HS6ST-1; heparan-sulfate 6-O-sulfotransferase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395141); (R-GGA-2022928)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "14660620;20039926", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB093515.1, CR386631.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN08016665, SAMN08016667 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1. On Nov 23, 2021 this sequence version replaced NP_989813.1., [RefSeq]; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate (By similarity). May also play a role in limb development., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Study showed that one heparan sulfate 2-O-sulfotransferase (HS2ST) and two isoforms of heparan sulfate 6-O-sulfotransferase (HS6ST-1 and -2) occurred in chick embryos and showed where the transcripts were distributed throughout the limb bud, [RefSeq, PubMed]; The chick HS6ST-1 transcripts is preferentially localized in the anterior and posterior proximal regions of the limb buds, respectively., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0017095 heparan sulfate 6-sulfotransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0060173 limb development;GO:0048666 neuron development;GO:0015012 heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q76KB2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62303-1", "uniprot_id": [ { "id": "RUXE_CHICK", "url": "https://www.uniprot.org/uniprot/P62303", "type": "external" } ], "mass": 10804.0, "length": 92, "protein_name": "Small nuclear ribonucleoprotein E", "gene_name": "SNRPE", "organism": "Chicken", "refseq_name": "small nuclear ribonucleoprotein E", "refseq_ac": [ { "id": "NP_990581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990581", "type": "external" } ], "gene_names_uniprotkb": "SNRPE", "gene_names_refseq": "SNRPE", "protein_names_uniprotkb": "Small nuclear ribonucleoprotein E; Sm protein E; Sm-E; SmE; snRNP-E", "protein_names_refseq": "SmE protein; sm protein E; sm-E; small nuclear ribonucleoprotein E; snRNP-E", "tax_id": 9031, "disease": "", "pathway": " (gga:396180); (R-GGA-111367); (R-GGA-191859); (R-GGA-72163); (R-GGA-72165); (R-GGA-73856); (R-GGA-77588); (R-GGA-9770562)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "1478669", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CN228948.1, BU354168.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000356.1., [RefSeq]; Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. As part of the U7 snRNP it is involved in histone 3'-end processing., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P08578;Q15498", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005829 cytosol;GO:0034709 methylosome;GO:0005686 U2 snRNP", "go_biological_process": "GO:0000387 spliceosomal snRNP assembly;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62303-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZHW4-1", "uniprot_id": [ { "id": "RAB5B_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZHW4", "type": "external" } ], "mass": 23615.0, "length": 215, "protein_name": "Ras-related protein Rab-5B", "gene_name": "RAB5B", "organism": "Chicken", "refseq_name": "ras-related protein Rab-5B", "refseq_ac": [ { "id": "NP_001186777", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186777", "type": "external" } ], "gene_names_uniprotkb": "RAB5B; RCJMB04_32j11", "gene_names_refseq": "RAB5B", "protein_names_uniprotkb": "Ras-related protein Rab-5B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-5B", "tax_id": 9031, "disease": "", "pathway": " (gga:100529061); (R-GGA-6798695); (R-GGA-8856828); (R-GGA-8876198)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "15642098;16879355", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01169604.1, SRR13267658.23375.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000490.1., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in early endocytic trafficking. Required for EEA1 recruitment to early endosomes. Required for EGF and transferrin endocytosis and trafficking through early endosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0031901 early endosome membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0016197 endosomal transport;GO:0048227 plasma membrane to endosome transport;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZHW4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28683-1", "uniprot_id": [ { "id": "OPSG_CHICK", "url": "https://www.uniprot.org/uniprot/P28683", "type": "external" } ], "mass": 39967.0, "length": 355, "protein_name": "Green-sensitive opsin", "gene_name": "OPN1MSW; PRA1", "organism": "Chicken", "refseq_name": "green-sensitive opsin", "refseq_ac": [ { "id": "NP_990821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990821", "type": "external" } ], "gene_names_uniprotkb": "OPN1MSW; PRA1", "gene_names_refseq": "CHK-1; OPN1MSW; OPNG; PRA1; RHO", "protein_names_uniprotkb": "Green-sensitive opsin; Green cone photoreceptor pigment", "protein_names_refseq": "green cone photoreceptor pigment; green sensitive cone opsin; green-sensitive opsin; opsin CHK-1; opsin, green senitive (rhodopsin-like); rhodopsin (opsin 2, rod pigment) (retinitis pigmentosa 4, autosomal dominant)", "tax_id": 9031, "disease": "", "pathway": " (gga:396486)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1385866;1554715;15697246;19457115;23383325;26324327", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M92038.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA103992290 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M92038.1., [RefSeq]; The increase in rhodopsin mRNA levels evoked by a series of cAMP analogs suggested the response was mediated by protein kinase A.These results suggest a cAMP-mediated signaling pathway may play a role in rod differentiation., [RefSeq, PubMed]; The meta-III decay rate is about 700 times faster in chicken green than in rhodopsin; the faster decay of chicken green can be converted to the slower decay in rhodopsin by replacing the residues in chicken green with the corresponding rhodopsin residues., [RefSeq, PubMed]; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity;GO:0004930 G protein-coupled receptor activity;GO:0046872 metal ion binding;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment;GO:0016020 membrane", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P28683-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "R4GKK6-1", "uniprot_id": [ { "id": "R4GKK6_CHICK", "url": "https://www.uniprot.org/uniprot/R4GKK6", "type": "external" } ], "mass": 82047.0, "length": 752, "protein_name": "Solute carrier family 26 member 6", "gene_name": "SLC26A6", "organism": "Chicken", "refseq_name": "solute carrier family 26 member 6", "refseq_ac": [ { "id": "NP_001239183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239183", "type": "external" } ], "gene_names_uniprotkb": "SLC26A6", "gene_names_refseq": "SLC26A6", "protein_names_uniprotkb": "Solute carrier family 26 member 6", "protein_names_refseq": "solute carrier family 26 (anion exchanger), member 6; solute carrier family 26 member 6", "tax_id": 9031, "disease": "", "pathway": " (gga:416012); (R-GGA-427601)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA103992323, SAMEA103992428 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000252.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015499 formate transmembrane transporter activity;GO:0030165 PDZ domain binding;GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0031526 brush border membrane;GO:0012506 vesicle membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0042045 epithelial fluid transport;GO:0015797 mannitol transmembrane transport;GO:0046724 oxalic acid secretion;GO:0071320 cellular response to cAMP", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "R4GKK6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZIS0-1", "uniprot_id": [ { "id": "DHSD_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZIS0", "type": "external" } ], "mass": 16435.0, "length": 157, "protein_name": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial", "gene_name": "SDHD", "organism": "Chicken", "refseq_name": "succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial", "refseq_ac": [ { "id": "NP_001006321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006321", "type": "external" } ], "gene_names_uniprotkb": "SDHD; RCJMB04_23p7", "gene_names_refseq": "SDHD", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; CybS; Malate dehydrogenase [quinone] cytochrome b small subunit; Succinate dehydrogenase complex subunit D; Succinate-ubiquinone oxidoreductase cytochrome b small subunit; Succinate-ubiquinone reductase membrane anchor subunit", "protein_names_refseq": "cybS; malate dehydrogenase [quinone] cytochrome b small subunit; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial; succinate dehydrogenase complex, subunit D, integral membrane protein; succinate-ubiquinone oxidoreductase cytochrome b small subunit; succinate-ubiquinone reductase membrane anchor subunit", "tax_id": 9031, "disease": "", "pathway": " (gga:419793); (R-GGA-71403)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "15642098;15805592;16371358;16935256", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720714.1, AJ450044.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05341171 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000341.1. On Jan 13, 2005 this sequence version replaced XP_417930.1., [RefSeq]; Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:16371358). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (By similarity). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0048039 ubiquinone binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006121 mitochondrial electron transport, succinate to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5ZIS0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53666-1", "uniprot_id": [ { "id": "LIMK2_CHICK", "url": "https://www.uniprot.org/uniprot/P53666", "type": "external" } ], "mass": 72468.0, "length": 642, "protein_name": "LIM domain kinase 2", "gene_name": "LIMK2", "organism": "Chicken", "refseq_name": "LIM domain kinase 2 isoform 2", "refseq_ac": [ { "id": "NP_990446", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990446", "type": "external" } ], "gene_names_uniprotkb": "LIMK2; LIMK", "gene_names_refseq": "LIMK2; LIMK", "protein_names_uniprotkb": "LIM domain kinase 2; 2.7.11.1; LIMK-2", "protein_names_refseq": "LIM domain kinase 2 isoform 2", "tax_id": 9031, "disease": "", "pathway": " (gga:396010)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "28531200;7852284", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D26310.1, SRR13267658.20725.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000260.1., [RefSeq]; Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP., [UniProtKB, UniProtKB]; Study identified miR-202-5p as one of the several novel miRNAs, and their target genes LIMK2, which may be involved in spermatogenesis and germline stem cell development in chicken. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0072686 mitotic spindle;GO:0005819 spindle", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0030036 actin cytoskeleton organization;GO:0030953 astral microtubule organization;GO:1902018 negative regulation of cilium assembly;GO:1900182 positive regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P53666-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57535-1", "uniprot_id": [ { "id": "NDK_CHICK", "url": "https://www.uniprot.org/uniprot/O57535", "type": "external" } ], "mass": 17288.0, "length": 153, "protein_name": "Nucleoside diphosphate kinase", "gene_name": "NME2", "organism": "Chicken", "refseq_name": "nucleoside diphosphate kinase", "refseq_ac": [ { "id": "NP_990378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990378", "type": "external" } ], "gene_names_uniprotkb": "NME2", "gene_names_refseq": "CNDPK; NDPK2; NME2", "protein_names_uniprotkb": "Nucleoside diphosphate kinase; 2.7.4.6; NDK; NDP kinase", "protein_names_refseq": "NDK; NDP kinase; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside diphosphate kinase 2; nucleoside diphosphate kinase", "tax_id": 9031, "disease": "", "pathway": " (gga:395916); (R-GGA-499943); (R-GGA-6798695); (R-GGA-9755088)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "26673886", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU143540.1, CF250843.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000316.1., [RefSeq]; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)., [UniProtKB]; NDPK2 plays a crucial role downstream of T3 action and that its phosphorylation is involved in the non-genomic signaling during imprinting., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "2.7.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.9", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0030027 lamellipodium;GO:0001726 ruffle", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0042981 regulation of apoptotic process;GO:0050679 positive regulation of epithelial cell proliferation;GO:0045682 regulation of epidermis development;GO:0045618 positive regulation of keratinocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O57535-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3YK19-1", "uniprot_id": [ { "id": "FANCJ_CHICK", "url": "https://www.uniprot.org/uniprot/Q3YK19", "type": "external" } ], "mass": 140105.0, "length": 1252, "protein_name": "Fanconi anemia group J protein homolog", "gene_name": "BRIP1", "organism": "Chicken", "refseq_name": "Fanconi anemia group J protein homolog", "refseq_ac": [ { "id": "NP_001028230", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028230", "type": "external" } ], "gene_names_uniprotkb": "BRIP1; FANCJ", "gene_names_refseq": "BRIP1; FANCJ", "protein_names_uniprotkb": "Fanconi anemia group J protein homolog; 5.6.2.3; DNA 5'-3' helicase FANCJ", "protein_names_refseq": "ATP-dependent RNA helicase BRIP1; DNA 5'-3' helicase FANCJ; Fanconi anemia group J protein homolog; Protein FACJ", "tax_id": 9031, "disease": "", "pathway": " (gga:417642); (R-GGA-351465); (R-GGA-5685938); (R-GGA-5685942); (R-GGA-5693537); (R-GGA-5693568); (R-GGA-5693579); (R-GGA-5693607); (R-GGA-5693616)", "pathway_count": 9, "publication_count": 7, "publication_id_list": "11239454;12086603;12442171;16116421;17412408;17452773;17460694", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.251973.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000323.1. On or before Dec 9, 2021 this sequence version replaced XP_015151274.1, XP_415887.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; DNA-dependent helicase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability (PubMed:16116421). Involved in the repair of DNA double-strand breaks by homologous recombination (By similarity). Involved in the repair of abasic sites at replication forks by promoting the degradation of DNA-protein cross-links: acts by catalyzing unfolding of HMCES DNA-protein cross-link via its helicase activity, exposing the underlying DNA and enabling cleavage of the DNA-protein adduct by the SPRTN metalloprotease (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0005657 replication fork", "go_biological_process": "GO:0006281 DNA repair;GO:1990918 double-strand break repair involved in meiotic recombination;GO:0006289 nucleotide-excision repair;GO:0106300 protein-DNA covalent cross-linking repair", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q3YK19-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F3K4-1", "uniprot_id": [ { "id": "WDR48_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F3K4", "type": "external" } ], "mass": 76314.0, "length": 678, "protein_name": "WD repeat-containing protein 48", "gene_name": "WDR48", "organism": "Chicken", "refseq_name": "WD repeat-containing protein 48", "refseq_ac": [ { "id": "NP_001026135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026135", "type": "external" } ], "gene_names_uniprotkb": "WDR48; RCJMB04_14o15; UAF1", "gene_names_refseq": "UAF1; WDR48", "protein_names_uniprotkb": "WD repeat-containing protein 48; USP1-associated factor 1", "protein_names_refseq": "USP1-associated factor 1; WD repeat-containing protein 48", "tax_id": 9031, "disease": "", "pathway": " (gga:420427); (R-GGA-110314); (R-GGA-5689880); (R-GGA-6783310)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "15642098;21482670", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851646.1, SRR13267661.4604.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000035.1. On Aug 8, 2005 this sequence version replaced XP_418532.1., [RefSeq]; Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. Also activates deubiquitinating activity of complexes containing USP12. Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme. Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination. Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes. Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress., [UniProtKB, UniProtKB]; Results indicate that the USP1/UAF1 complex promotes homologous recombination, at least in part by suppressing nonhomologous end-joining., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003690 double-stranded DNA binding;GO:0043130 ubiquitin binding;GO:0003697 single-stranded DNA binding;GO:0035800 deubiquitinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:0006974 DNA damage response;GO:0046427 positive regulation of receptor signaling pathway via JAK-STAT;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0000724 double-strand break repair via homologous recombination;GO:1905168 positive regulation of double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5F3K4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q71R50-1", "uniprot_id": [ { "id": "DHR11_CHICK", "url": "https://www.uniprot.org/uniprot/Q71R50", "type": "external" } ], "mass": 27727.0, "length": 255, "protein_name": "Dehydrogenase/reductase SDR family member 11", "gene_name": "DHRS11", "organism": "Chicken", "refseq_name": "dehydrogenase/reductase SDR family member 11 precursor", "refseq_ac": [ { "id": "NP_989838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989838", "type": "external" } ], "gene_names_uniprotkb": "DHRS11; SDR24C1", "gene_names_refseq": "DHRS11; SDR24C1", "protein_names_uniprotkb": "Dehydrogenase/reductase SDR family member 11; 1.1.1.270; 1.1.1.62; 17-beta-hydroxysteroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; Estradiol 17-beta-dehydrogenase; Short-chain dehydrogenase/reductase family 24C member 1", "protein_names_refseq": "17-beta-hydroxysteroid dehydrogenase; 3-beta-hydroxysteroid 3-dehydrogenase; dehydrogenase/reductase (SDR family) member 11; dehydrogenase/reductase SDR family member 11 precursor; estradiol 17-beta-dehydrogenase; short-chain dehydrogenase/reductase family 24C member 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395172)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.161047.1, SRR13267654.220260.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000323.1., [RefSeq]; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.270", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.270", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.210", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.210", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.1.1.n12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12", "type": "external" }, { "id": "1.1.1.330", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.330", "type": "external" } ], "go_molecular_function": "GO:0072582 17-beta-hydroxysteroid dehydrogenase (NADP+) activity;GO:0000166 nucleotide binding;GO:0004303 estradiol 17-beta-dehydrogenase [NAD(P)+] activity;GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006703 estrogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q71R50-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NZ44-1", "uniprot_id": [ { "id": "F1NZ44_CHICK", "url": "https://www.uniprot.org/uniprot/F1NZ44", "type": "external" } ], "mass": 74483.0, "length": 670, "protein_name": "Transporter", "gene_name": "SLC6A4", "organism": "Chicken", "refseq_name": "sodium-dependent serotonin transporter isoform X1", "refseq_ac": [ { "id": "XP_015151185", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015151185", "type": "external" } ], "gene_names_uniprotkb": "SLC6A4", "gene_names_refseq": "SERT; SLC6A4", "protein_names_uniprotkb": "Transporter", "protein_names_refseq": "sodium-dependent serotonin transporter isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-380615); (R-GGA-442660)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052550.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0015297 antiporter activity;GO:0005335 serotonin:sodium:chloride symporter activity;GO:0005326 neurotransmitter transmembrane transporter activity;GO:0005178 integrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0010008 endosome membrane;GO:0043005 neuron projection;GO:0098793 presynapse", "go_biological_process": "GO:0046621 negative regulation of organ growth;GO:0048484 enteric nervous system development;GO:0010628 positive regulation of gene expression;GO:0009636 response to toxic substance;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NZ44-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F3E8-1", "uniprot_id": [ { "id": "BACD2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F3E8", "type": "external" } ], "mass": 36032.0, "length": 314, "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2", "gene_name": "TNFAIP1", "organism": "Chicken", "refseq_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2", "refseq_ac": [ { "id": "NP_001025897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025897", "type": "external" } ], "gene_names_uniprotkb": "TNFAIP1; RCJMB04_19f9", "gene_names_refseq": "TNFAIP1", "protein_names_uniprotkb": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1", "protein_names_refseq": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1; tumor necrosis factor, alpha-induced protein 1 (endothelial)", "tax_id": 9031, "disease": "", "pathway": " (gga:417672); (R-GGA-9696264); (R-GGA-9696270)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851702.1, SRR13267655.89519.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000323.1. On Aug 8, 2005 this sequence version replaced XP_415918.1., [RefSeq]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0006955 immune response;GO:0016477 cell migration;GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F3E8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NXH3-1", "uniprot_id": [ { "id": "F1NXH3_CHICK", "url": "https://www.uniprot.org/uniprot/F1NXH3", "type": "external" } ], "mass": 51859.0, "length": 478, "protein_name": "Dual specificity protein phosphatase 10", "gene_name": "DUSP10", "organism": "Chicken", "refseq_name": "dual specificity protein phosphatase 10", "refseq_ac": [ { "id": "NP_001026215", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026215", "type": "external" } ], "gene_names_uniprotkb": "DUSP10", "gene_names_refseq": "DUSP10", "protein_names_uniprotkb": "Dual specificity protein phosphatase 10; 3.1.3.16; 3.1.3.48", "protein_names_refseq": "dual specificity protein phosphatase 10", "tax_id": 9031, "disease": "", "pathway": " (gga:421340); (R-GGA-112409); (R-GGA-5675221)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720476.1, SRR13267654.61588.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000062.1. On Sep 23, 2021 this sequence version replaced NP_001026215.1., [RefSeq]; Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily. It preferably dephosphorylates p38., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0048273 mitogen-activated protein kinase p38 binding;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0050680 negative regulation of epithelial cell proliferation;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0046329 negative regulation of JNK cascade;GO:1903753 negative regulation of p38MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NXH3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NXU8-1", "uniprot_id": [ { "id": "NCLX_CHICK", "url": "https://www.uniprot.org/uniprot/F1NXU8", "type": "external" } ], "mass": 64331.0, "length": 593, "protein_name": "Mitochondrial sodium/calcium exchanger protein", "gene_name": "SLC8B1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC8B1; NCKX6; NCLX", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial sodium/calcium exchanger protein; Na(+)/K(+)/Ca(2+)-exchange protein 6; Sodium/calcium exchanger protein, mitochondrial; Sodium/potassium/calcium exchanger 6; Solute carrier family 8 member B1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15592404;27328625", "class_list": "", "function": "Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (By similarity). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (By similarity). Mitochondrial calcium export is ph-dependent (By similarity). Involved in B-lymphocyte chemotaxis (PubMed:27328625)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005432 calcium:sodium antiporter activity;GO:0086038 calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0051560 mitochondrial calcium ion homeostasis;GO:2001256 regulation of store-operated calcium entry;GO:1901623 regulation of lymphocyte chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1NXU8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1NYE6-1", "uniprot_id": [ { "id": "F1NYE6_CHICK", "url": "https://www.uniprot.org/uniprot/F1NYE6", "type": "external" } ], "mass": 52742.0, "length": 454, "protein_name": "Phosphatidate cytidylyltransferase", "gene_name": "CDS1", "organism": "Chicken", "refseq_name": "phosphatidate cytidylyltransferase 1", "refseq_ac": [ { "id": "XP_420571", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_420571", "type": "external" } ], "gene_names_uniprotkb": "CDS1", "gene_names_refseq": "CDS1", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase; 2.7.7.41", "protein_names_refseq": "phosphatidate cytidylyltransferase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:422611); (R-GGA-1483226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 19, 2013 this sequence version replaced XP_420571.3. COMPLETENESS: full length., [RefSeq]; Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.41", "type": "external" } ], "go_molecular_function": "GO:0004605 phosphatidate cytidylyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045600 positive regulation of fat cell differentiation;GO:0006661 phosphatidylinositol biosynthetic process;GO:0140042 lipid droplet formation;GO:0016024 CDP-diacylglycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1NYE6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1P065-1", "uniprot_id": [ { "id": "FARP1_CHICK", "url": "https://www.uniprot.org/uniprot/F1P065", "type": "external" } ], "mass": 119705.0, "length": 1046, "protein_name": "FERM, ARHGEF and pleckstrin domain-containing protein 1", "gene_name": "FARP1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FARP1", "gene_names_refseq": "", "protein_names_uniprotkb": "FERM, ARHGEF and pleckstrin domain-containing protein 1; FERM, RhoGEF and pleckstrin domain-containing protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15592404;19217374", "class_list": "", "function": "Functions as a guanine nucleotide exchange factor for RAC1 (By similarity). Plays a role in semaphorin signaling via its interaction with PLXNA4. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030425 dendrite;GO:0043197 dendritic spine;GO:0030175 filopodium;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007416 synapse assembly;GO:0048813 dendrite morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1P065-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1P0N0-1", "uniprot_id": [ { "id": "F1P0N0_CHICK", "url": "https://www.uniprot.org/uniprot/F1P0N0", "type": "external" } ], "mass": 78132.0, "length": 690, "protein_name": "SKI like proto-onco", "gene_name": "SKIL", "organism": "Chicken", "refseq_name": "ski-like protein", "refseq_ac": [ { "id": "NP_990505", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990505", "type": "external" } ], "gene_names_uniprotkb": "SKIL", "gene_names_refseq": "SKIL; SNO; c-sno", "protein_names_uniprotkb": "SKI like proto-onco", "protein_names_refseq": "SKI-like oncogene; ski-like protein; ski-related; snoN", "tax_id": 9031, "disease": "", "pathway": " (gga:396087); (R-GGA-2173795)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16966324;19717568", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.284543.1, SRR13267659.292513.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1. On Nov 15, 2021 this sequence version replaced NP_990505.1., [RefSeq]; SnoN (SKIL) is expressed in the tip of the growing digit cartilage primordia, and in the developing joints. The addition of TGF beta in micromass cultures is quickly followed by an intense up-regulation of this TGF beta-signaling repressor., [RefSeq, PubMed]; SnoN is directly regulated by sumoylation leading to the enhancement of the ability of SnoN to repress transcription in a promoter-specific manner, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0019904 protein domain specific binding;GO:0042803 protein homodimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0030514 negative regulation of BMP signaling pathway;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1P0N0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1P0W5-1", "uniprot_id": [ { "id": "F1P0W5_CHICK", "url": "https://www.uniprot.org/uniprot/F1P0W5", "type": "external" } ], "mass": 15919.0, "length": 148, "protein_name": "Hypocretin neuropeptide precursor", "gene_name": "HCRT", "organism": "Chicken", "refseq_name": "hypocretin neuropeptide precursor isoform 1 precursor", "refseq_ac": [ { "id": "NP_989516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989516", "type": "external" } ], "gene_names_uniprotkb": "HCRT", "gene_names_refseq": "HCRT", "protein_names_uniprotkb": "Hypocretin neuropeptide precursor; Hypocretin; Orexin precursor; Prepro-orexin; Preprohypocretin", "protein_names_refseq": "hypocretin (orexin) neuropeptide; hypocretin neuropeptide precursor isoform 1 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:374005); (R-GGA-416476)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "23548597", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01118493.1, AB056748.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051, SAMN06140853 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000365.1. On Oct 17, 2021 this sequence version replaced NP_989516.1., [RefSeq]; Binds to orexin receptor HCRTR2/OX2R only. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner., [UniProtKB, UniProtKB]; Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity. Stimulates food intake. Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner., [UniProtKB, UniProtKB]; This study found evidence that hypothalamic orexin plays a role in the sleep-wake cycle and it may be involved in aspects of energy balance., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031771 type 1 orexin receptor binding;GO:0031772 type 2 orexin receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0043025 neuronal cell body;GO:0045177 apical part of cell;GO:0045202 synapse", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0007218 neuropeptide signaling pathway;GO:0042594 response to starvation;GO:0042755 eating behavior;GO:0046928 regulation of neurotransmitter secretion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1P0W5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1P1Z5-1", "uniprot_id": [ { "id": "F1P1Z5_CHICK", "url": "https://www.uniprot.org/uniprot/F1P1Z5", "type": "external" } ], "mass": 50770.0, "length": 470, "protein_name": "SRY-box 8", "gene_name": "SOX8", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SOX8", "gene_names_refseq": "", "protein_names_uniprotkb": "SRY-box 8", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395483)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0048484 enteric nervous system development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1P1Z5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1P4I3-1", "uniprot_id": [ { "id": "F1P4I3_CHICK", "url": "https://www.uniprot.org/uniprot/F1P4I3", "type": "external" } ], "mass": 11688.0, "length": 104, "protein_name": "Vesicle-associated membrane protein 3", "gene_name": "VAMP3", "organism": "Chicken", "refseq_name": "vesicle-associated membrane protein 3", "refseq_ac": [ { "id": "NP_001034578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034578", "type": "external" } ], "gene_names_uniprotkb": "VAMP3", "gene_names_refseq": "VAMP3", "protein_names_uniprotkb": "Vesicle-associated membrane protein 3", "protein_names_refseq": "vesicle-associated membrane protein 3 (cellubrevin); vesicle-associated membrane protein 3", "tax_id": 9031, "disease": "", "pathway": " (gga:419368); (R-GGA-1236974); (R-GGA-6811440); (R-GGA-8856825); (R-GGA-8856828); (R-GGA-8980692); (R-GGA-9013026); (R-GGA-9013106); (R-GGA-9013149); (R-GGA-9013404); (R-GGA-9013406); (R-GGA-9013407); (R-GGA-9013408); (R-GGA-9013423); (R-GGA-9035034)", "pathway_count": 15, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BM488089.1, AM067284.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM488089.1, BX929338.2 and BI067069.1. On Feb 13, 2006 this sequence version replaced XP_417529.1. Sequence Note: This RefSeq record was created from transcript sequence data from multiple strains because no single transcript from the same strain was available for the full length of the gene., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity;GO:0017075 syntaxin-1 binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030141 secretory granule", "go_biological_process": "GO:0034446 substrate adhesion-dependent cell spreading;GO:0001921 positive regulation of receptor recycling;GO:0042147 retrograde transport, endosome to Golgi;GO:0035493 SNARE complex assembly;GO:0006906 vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1P4I3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1P4W9-1", "uniprot_id": [ { "id": "CFA65_CHICK", "url": "https://www.uniprot.org/uniprot/F1P4W9", "type": "external" } ], "mass": 197765.0, "length": 1775, "protein_name": "Cilia- and flagella-associated protein 65", "gene_name": "CFAP65", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CFAP65; CCDC108", "gene_names_refseq": "", "protein_names_uniprotkb": "Cilia- and flagella-associated protein 65; Coiled-coil domain-containing protein 108", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15592404;22761584", "class_list": "", "function": "Plays a crucial role in sperm flagellar formation and motility (PubMed:22761584). Essential for acrosome formation, manchette organization, spermatid head morphogenesis and mitochondrial sheath assembly within the sperm flagellum during spermiogenesis (By similarity). Also required for proper assembly and stabilization of the C2a projection, a structural subunit of the central pair apparatus within the axoneme of motile cilia and flagella (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "I6WQT8", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:1990716 axonemal central apparatus;GO:0005737 cytoplasm;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:0002080 acrosomal membrane", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0001675 acrosome assembly;GO:0003341 cilium movement;GO:0007288 sperm axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1P4W9-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F6S3W4-1", "uniprot_id": [ { "id": "F6S3W4_CHICK", "url": "https://www.uniprot.org/uniprot/F6S3W4", "type": "external" } ], "mass": 48467.0, "length": 425, "protein_name": "Bone morphogenetic protein 10", "gene_name": "BMP10", "organism": "Chicken", "refseq_name": "bone morphogenetic protein 10 precursor", "refseq_ac": [ { "id": "NP_001264975", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264975", "type": "external" } ], "gene_names_uniprotkb": "BMP10", "gene_names_refseq": "BMP-10; BMP10", "protein_names_uniprotkb": "Bone morphogenetic protein 10", "protein_names_refseq": "bone morphogenetic protein 10 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:395177); (R-GGA-201451); (R-GGA-2129379)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "14722768;15224399", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ581667.1, SRR13267649.200334.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051, SAMN06140853 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000331.1. On May 4, 2013 this sequence version replaced XP_417667.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines., [UniProtKB, UniProtKB]; The expression of the BMP10 gene during chick development [BMP10], [RefSeq, PubMed]; The observed expression pattern of BMP10 mRNA suggests that it may play a role in regulating the formation of the ventricular wall and trabecules., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0031433 telethonin binding;GO:0033612 receptor serine/threonine kinase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0030018 Z disc", "go_biological_process": "GO:0007155 cell adhesion;GO:0045893 positive regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth;GO:0030509 BMP signaling pathway;GO:0010596 negative regulation of endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F6S3W4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F7BGT1-1", "uniprot_id": [ { "id": "F7BGT1_CHICK", "url": "https://www.uniprot.org/uniprot/F7BGT1", "type": "external" } ], "mass": 18070.0, "length": 156, "protein_name": "Oxidized purine nucleoside triphosphate hydrolase", "gene_name": "NUDT1", "organism": "Chicken", "refseq_name": "oxidized purine nucleoside triphosphate hydrolase", "refseq_ac": [ { "id": "NP_001006160", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006160", "type": "external" } ], "gene_names_uniprotkb": "NUDT1", "gene_names_refseq": "NUDT1", "protein_names_uniprotkb": "Oxidized purine nucleoside triphosphate hydrolase; 2-hydroxy-dATP diphosphatase; 3.6.1.56; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; Methylated purine nucleoside triphosphate hydrolase; Nucleoside diphosphate-linked moiety X motif 1", "protein_names_refseq": "nudix (nucleoside diphosphate linked moiety X)-type motif 1; oxidized purine nucleoside triphosphate hydrolase", "tax_id": 9031, "disease": "", "pathway": " (gga:416467); (R-GGA-2393930)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU411655.1, BU394260.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. On Jan 4, 2008 this sequence version replaced NP_001006160.1., [RefSeq]; Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.56", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity;GO:0030515 snoRNA binding;GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity;GO:0047693 ATP diphosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0042262 DNA protection;GO:0006152 purine nucleoside catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F7BGT1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "K9JA28-1", "uniprot_id": [ { "id": "INLR1_CHICK", "url": "https://www.uniprot.org/uniprot/K9JA28", "type": "external" } ], "mass": 64663.0, "length": 567, "protein_name": "Interferon lambda receptor 1", "gene_name": "IFNLR1", "organism": "Chicken", "refseq_name": "interferon lambda receptor 1 precursor", "refseq_ac": [ { "id": "NP_001376470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376470", "type": "external" } ], "gene_names_uniprotkb": "IFNLR1; IL28RA", "gene_names_refseq": "CRF2-12; IFNLR1; IL-28RA; IL28RA", "protein_names_uniprotkb": "Interferon lambda receptor 1; CRF2-12; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; IFN-lambda R1; IL-28 receptor subunit alpha; IL-28R-alpha; IL-28RA; Interleukin-28 receptor subunit alpha", "protein_names_refseq": "Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12; IFN-lambda R1; IL-28 receptor subunit alpha; IL-28R-alpha; Interleukin-28 receptor subunit alpha; interferon lambda receptor 1 precursor; interferon lambda receptor isotype 1; interferon lambda receptor soluble 1; interleukin 28 receptor, alpha (interferon, lambda receptor)", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-449836); (R-GGA-8854691)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15592404;24371053", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: KF680104.1, SRR12888508.80654.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000339.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "K9J9W8;W0FB28", "ec_number_list": [], "go_molecular_function": "GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0051607 defense response to virus;GO:0019221 cytokine-mediated signaling pathway;GO:0034342 response to type III interferon", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "K9JA28-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O12944-1", "uniprot_id": [ { "id": "RAD54_CHICK", "url": "https://www.uniprot.org/uniprot/O12944", "type": "external" } ], "mass": 82765.0, "length": 733, "protein_name": "DNA repair and recombination protein RAD54-like", "gene_name": "RAD54L", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RAD54L; RAD54", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA repair and recombination protein RAD54-like; 3.6.4.-; Putative recombination factor GdRad54; RAD54 homolog", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:424611)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9108474", "class_list": "", "function": "Multifunctional ATPase that plays a role in homologous recombination (HR) which is a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Acts as a molecular motor during the homology search and guides RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism. Also plays an essential role in RAD51-mediated synaptic complex formation which consists of three strands encased in a protein filament formed once homology is recognized. Once DNA strand exchange occured, dissociates RAD51 from nucleoprotein filaments formed on dsDNA., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0036310 ATP-dependent DNA/DNA annealing activity;GO:0015616 DNA translocase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0007131 reciprocal meiotic recombination;GO:0045003 double-strand break repair via synthesis-dependent strand annealing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O12944-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O13035-1", "uniprot_id": [ { "id": "SAP_CHICK", "url": "https://www.uniprot.org/uniprot/O13035", "type": "external" } ], "mass": 57601.0, "length": 518, "protein_name": "Prosaposin", "gene_name": "PSAP", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PSAP", "gene_names_refseq": "", "protein_names_uniprotkb": "Prosaposin; Proactivator polypeptide", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395602)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9461526", "class_list": "", "function": "Acts as a lysosomal activator protein that stimulates acid ceramidase (EC 3.5.1.23) by solubilizing and presenting ceramide substrates at the lipid-water interface, facilitating their hydrolysis into sphingosine and fatty acids. It also activates acid sphingomyelinase (EC 3.1.4.12), though ceramide catabolism represents its primary physiological role., [UniProtKB, UniProtKB]; Acts as an essential lysosomal cofactor that activates acid beta-glucosylceramidases (EC 3.2.1.45) by altering lipid bilayer properties to facilitate enzyme access to its membrane-embedded glucosylceramide substrate, while also protecting glucocerebrosidase from intralysosomal proteolytic degradation., [UniProtKB, UniProtKB]; Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling., [UniProtKB, UniProtKB, UniProtKB]; Saposins are specific low-molecular mass non-enzymatic glycoproteins that act as activator proteins for lysosomal sphingolipid-degrading enzymes, facilitating the hydrolysis of sphingolipids by extracting lipid substrates from membranes and presenting them to their respective enzymes. They are derived from a common precursor protein, prosaposin, which is proteolytically cleaved to yield four homologous proteins (saposin A, B, C, and D), each with distinct but partially overlapping lipid and enzyme specificities., [UniProtKB, UniProtKB]; Stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A ARSA (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases., [UniProtKB, UniProtKB]; acts as an essential lysosomal cofactor that activates galactocerebrosidase (GALC, EC 3.2.1.46) by facilitating enzyme access to its membrane-embedded galactosylceramide substrate, the principal lipid component of myelin., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005764 lysosome", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0006665 sphingolipid metabolic process;GO:0019216 regulation of lipid metabolic process;GO:0060736 prostate gland growth;GO:0060742 epithelial cell differentiation involved in prostate gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O13035-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42146-1", "uniprot_id": [ { "id": "TIMP2_CHICK", "url": "https://www.uniprot.org/uniprot/O42146", "type": "external" } ], "mass": 24313.0, "length": 220, "protein_name": "Metalloproteinase inhibitor 2", "gene_name": "TIMP2", "organism": "Chicken", "refseq_name": "metalloproteinase inhibitor 2 precursor", "refseq_ac": [ { "id": "NP_989629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989629", "type": "external" } ], "gene_names_uniprotkb": "TIMP2", "gene_names_refseq": "TIMP2", "protein_names_uniprotkb": "Metalloproteinase inhibitor 2; TIMP-2; Tissue inhibitor of metalloproteinases 2", "protein_names_refseq": "TIMP-2; metalloproteinase inhibitor 2 precursor; metalloproteinase inhibitor 2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2", "tax_id": 9031, "disease": "", "pathway": " (gga:374178)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15497141;16537168;17295208;23218521;26395636;27342592;9462696", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.150610.1, DR424804.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000317.1. On Sep 23, 2021 this sequence version replaced NP_989629.1., [RefSeq]; Age-related changes of MMP-13 with balance of TIMPs act in concert to effect the controlled testicular remodeling and maturation., [RefSeq, PubMed]; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor., [UniProtKB]; Distribution of matrix metalloproteinase (MMP)-2, MMP-9, tissue inhibitor of matrix metalloproteinase (TIMP)-1 and TIMP-2 using immunohistochemistry in the ascites syndrome of broiler chickens in a salt-induced experimental model, [RefSeq, PubMed]; Protein level of MMP-9 was diminished, while MMP-7 and TIMP-3 were elevated in the oviduct of growing birds. MMP-2 and TIMP-2 protein levels remained constant, with a slight increase in MMP-2 concentration just before reaching maturity., [RefSeq, PubMed]; Real-time polymerase chain reaction and western blot revealed different expression of MMP-2, -7, -9 and TIMP-2 and -3 on mRNA and protein levels, respectively, as well as activity of MMP-2 and -9 by activity assay in the oviduct parts., [RefSeq, PubMed]; TIMP-2 expression by cardiac neural crest cells initiates proMMP-2 activation important for their migration., [RefSeq, PubMed]; These findings collectively show for the first time that multiple MMPs, ADAMs, and TIMPs appear to functionally interact during corneal development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0034097 response to cytokine;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O42146-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42184-1", "uniprot_id": [ { "id": "CLIP1_CHICK", "url": "https://www.uniprot.org/uniprot/O42184", "type": "external" } ], "mass": 161027.0, "length": 1433, "protein_name": "CAP-Gly domain-containing linker protein 1", "gene_name": "CLIP1", "organism": "Chicken", "refseq_name": "CAP-Gly domain-containing linker protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001383593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383593", "type": "external" } ], "gene_names_uniprotkb": "CLIP1; RSN", "gene_names_refseq": "CLIP1; RSN", "protein_names_uniprotkb": "CAP-Gly domain-containing linker protein 1; CLIP-170; Cytoplasmic linker protein 170; Restin", "protein_names_refseq": "CAP-Gly domain-containing linker protein 1 isoform 2; CAP-Gly domain-containing linker protein 1; CLIP-170; cytoplasmic linker protein 170; cytoplasmic linker protein CLIP-170; restin", "tax_id": 9031, "disease": "", "pathway": " (gga:395784)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "9469933;9784600", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF014012.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF014012.1, AF045650.1, BU248759.1, BU226675.1, JAENSK010000260.1, CV039124.1 and BU234690.1. On or before Oct 25, 2021 this sequence version replaced XP_040504355.1, XP_040540477.1. Transcript Variant: This variant (2) has 25 exons. It is lacking the ninth exon, the eighteenth exon and the twenty-third exon. The eleventh intron is the longer variant. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O42228;O57563;O57564", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0051010 microtubule plus-end binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005938 cell cortex;GO:0030659 cytoplasmic vesicle membrane;GO:0001726 ruffle;GO:0035371 microtubule plus-end", "go_biological_process": "GO:0031116 positive regulation of microtubule polymerization;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O42184-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42224-1", "uniprot_id": [ { "id": "SMO_CHICK", "url": "https://www.uniprot.org/uniprot/O42224", "type": "external" } ], "mass": 88255.0, "length": 794, "protein_name": "Protein smoothened", "gene_name": "SMO", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SMO", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein smoothened", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9598354", "class_list": "", "function": "G protein-coupled receptor, which transduces the smoothened signaling pathway. Activated by cholesterol in response to hedgehog (DHH, IHH or SHH) morphogens. In absence of hedgehog, SMO is inactivated by patched protein (PTCH1 or PTCH2), which prevents SMO access to cholesterol. In response to hedgehog-binding to pathched, inhibition is relieved, promoting SMO translocation to primary cilium and activation by cholesterol: cholesterol causes a conformation change that triggers signaling via G protein G(i), mediating inhibition of adenylate cyclase activity and decreassed production of cAMP. Decreased cAMP levels then inhibit protein kinase A (PKA) and promote release of GLI (GLI1, GLI2 and GLI3) transcription factors, which activate expression of target genes. Active SMO also directly inhibits PKA by sequestering its catalytic subunit, PRKACA, at the cell membrane, preventing PRKACA-mediated phosphorylation and subsequent processing of GLI transcription factors., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034236 protein kinase A catalytic subunit binding;GO:0008142 oxysterol binding;GO:0004930 G protein-coupled receptor activity;GO:0005113 patched binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0030425 dendrite", "go_biological_process": "GO:0001933 negative regulation of protein phosphorylation;GO:0007417 central nervous system development;GO:0007224 smoothened signaling pathway;GO:0007389 pattern specification process;GO:0009888 tissue development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O42224-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42230-1", "uniprot_id": [ { "id": "GBX2_CHICK", "url": "https://www.uniprot.org/uniprot/O42230", "type": "external" } ], "mass": 35856.0, "length": 340, "protein_name": "Homeobox protein GBX-2", "gene_name": "GBX2", "organism": "Chicken", "refseq_name": "homeobox protein GBX-2", "refseq_ac": [ { "id": "NP_990399", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990399", "type": "external" } ], "gene_names_uniprotkb": "GBX2", "gene_names_refseq": "GBX1; GBX2", "protein_names_uniprotkb": "Homeobox protein GBX-2; Gastrulation and brain-specific homeobox protein 2", "protein_names_refseq": "gastrulation and brain-specific homeobox protein 2; gastrulation brain homeo box 2; gastrulation brain homeobox 1; gastrulation brain homeobox 2 protein; homeobox protein GBX-2", "tax_id": 9031, "disease": "", "pathway": " (gga:395950)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15465488;16961590;22564795;26826496;9346236", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF022151.1, BI393586.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992440, SAMEA103992453 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000235.1., [RefSeq]; DNMT3A is important for enabling the activation of Gbx2 expression, necessary for normal development of the inner ear, [RefSeq, PubMed]; May act as a transcription factor for cell pluripotency and differentiation in the embryo., [UniProtKB]; Otx2 and Gbx2 provide a global mechanism for patterning of the embryonic ectoderm and ensure the coordinated development of the central and peripheral nervous system in the head., [RefSeq, PubMed]; Otx2, Gbx2, and Fgf8 are expressed in the chick developing inner ear, [RefSeq, PubMed]; Results suggest that the interaction between Gbx2 and Otx2 in developing inner ear defines Fgf10 expression domain to induce the cochlear ganglion and that Gbx2 expression is important for the formation of the endolymphatic duct., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0051960 regulation of nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O42230-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42236-1", "uniprot_id": [ { "id": "SEM3C_CHICK", "url": "https://www.uniprot.org/uniprot/O42236", "type": "external" } ], "mass": 85433.0, "length": 751, "protein_name": "Semaphorin-3C", "gene_name": "SEMA3C", "organism": "Chicken", "refseq_name": "semaphorin-3C precursor", "refseq_ac": [ { "id": "NP_989574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989574", "type": "external" } ], "gene_names_uniprotkb": "SEMA3C; COLL3", "gene_names_refseq": "SEMA3C; semaphorin-3C", "protein_names_uniprotkb": "Semaphorin-3C; COLL-3; Collapsin-3", "protein_names_refseq": "COLL-3; collapsin-3; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; semaphorin-3C precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:374090)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "22899844;7605628;9331347", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267656.13567.1, ERR2286007.51501.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On or before Oct 27, 2021 this sequence version replaced XP_015156278.1, NP_989574.1., [RefSeq]; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin., [UniProtKB]; The role of the motoneuronal Sema3 code could be to set population-specific axon sensitivity to limb-derived chemotropic Sema3 proteins, therefore specifying stereotyped motor nerve trajectories in their target field., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q90664", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O42236-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42237-1", "uniprot_id": [ { "id": "SEM3E_CHICK", "url": "https://www.uniprot.org/uniprot/O42237", "type": "external" } ], "mass": 90979.0, "length": 785, "protein_name": "Semaphorin-3E", "gene_name": "SEMA3E", "organism": "Chicken", "refseq_name": "semaphorin-3E precursor", "refseq_ac": [ { "id": "NP_989573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989573", "type": "external" } ], "gene_names_uniprotkb": "SEMA3E; COLL5", "gene_names_refseq": "SEMA3E; semaphorin-3E", "protein_names_uniprotkb": "Semaphorin-3E; COLL-5; Collapsin-5", "protein_names_refseq": "COLL-5; collapsin-5; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; semaphorin-3E precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:374089)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16338115;7605628;9331347", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.185506.1, AF022947.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Nov 9, 2021 this sequence version replaced NP_989573.1., [RefSeq]; Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Induces the collapse and paralysis of neuronal growth cones. Plays an important role in ensuring the specificity of synapse formation (By similarity)., [UniProtKB]; Results suggest a molecular mechanism whereby ingrowth of retinal axons into the tectum can be regulated by semaphorin 3E/BDNF modulation without disturbing tectal axon growth out of the tectum mediated by Sema3A., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q90666", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O42237-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42281-1", "uniprot_id": [ { "id": "PRPH2_CHICK", "url": "https://www.uniprot.org/uniprot/O42281", "type": "external" } ], "mass": 40208.0, "length": 354, "protein_name": "Peripherin-2", "gene_name": "PRPH2", "organism": "Chicken", "refseq_name": "peripherin-2", "refseq_ac": [ { "id": "NP_990369", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990369", "type": "external" } ], "gene_names_uniprotkb": "PRPH2; RDS", "gene_names_refseq": "CRDS1; PRPH2; RDS; peripherin-2", "protein_names_uniprotkb": "Peripherin-2; CRDS1; Photoreceptor outer segment membrane glycoprotein 1; Retinal degeneration slow protein", "protein_names_refseq": "chicken retinal degeneration slow 1; peripherin-2; photoreceptor outer segment membrane glycoprotein 1; retinal degeneration slow protein; retinal degeneration, slow", "tax_id": 9031, "disease": "", "pathway": " (gga:395899)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "28539581;9478005", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF031238.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF031238.1., [RefSeq]; May be involved in the morphogenesis of retina outer segment disks and the development and maintenance of the retina ultrastructure., [UniProtKB, UniProtKB]; Our study unravels unexpected opposing roles of per(WT) and Rom-1 in rod outer segment (OS)targeting of adRP-linked peripherin-2 mutants and suggests a new treatment strategy for the affected individuals. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007155 cell adhesion;GO:0072659 protein localization to plasma membrane;GO:0007601 visual perception;GO:0060041 retina development in camera-type eye;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O42281-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42290-1", "uniprot_id": [ { "id": "MAFA_CHICK", "url": "https://www.uniprot.org/uniprot/O42290", "type": "external" } ], "mass": 32445.0, "length": 286, "protein_name": "Transcription factor MafA", "gene_name": "MAFA", "organism": "Chicken", "refseq_name": "transcription factor MafA", "refseq_ac": [ { "id": "NP_990356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990356", "type": "external" } ], "gene_names_uniprotkb": "MAFA", "gene_names_refseq": "L-MAF; MAFA; MAFL", "protein_names_uniprotkb": "Transcription factor MafA; L-Maf; Lens-specific Maf", "protein_names_refseq": "bZIP transcription factor L-Maf; lens-specific Maf; transcription factor MafA; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A", "tax_id": 9031, "disease": "", "pathway": " (gga:395881)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12970735;16247450;17428264;21761477;30328540;9525857", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: AF034570.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF034570.1. On Dec 9, 2006 this sequence version replaced XP_001232434.1., [RefSeq]; On the level of gene expression, GRIFIN's promoter was activated by transcription factor L-Maf alone and together with Pax6 like a crystallin gene, substantiating C-GRIFIN's status as lens-specific galectin., [RefSeq, PubMed]; Pegulates cell cycle exit of the posterior lens cells by activating cyclin-dependent kinase inhibitor p27 (p27kip1), and thus directs fiber cell differentiation during lens formation in chick., [RefSeq, PubMed]; Results show that before L-Maf induction BMP activity is required for lens specification, whereas after L-Maf up-regulation, the early differentiation of primary lens fibre cells occurs independent of BMP signals., [RefSeq, PubMed]; Transcription factor involved in transcription regulation during lens development, including that of crystallin and filensin/BFSP1 genes (PubMed:9525857). Binds to CRE-type MARE 5'-TGCTGACGTCAGCA-3' and TRE-type MARE 5'-TGCTGACTCAGCA-3' DNA sequences (PubMed:12970735)., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q8AWH8", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009749 response to glucose;GO:0030073 insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "O42290-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000100000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42393-1", "uniprot_id": [ { "id": "RAPSN_CHICK", "url": "https://www.uniprot.org/uniprot/O42393", "type": "external" } ], "mass": 46808.0, "length": 412, "protein_name": "43 kDa receptor-associated protein of the synapse", "gene_name": "RAPSN", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RAPSN", "gene_names_refseq": "", "protein_names_uniprotkb": "43 kDa receptor-associated protein of the synapse; 43 kDa postsynaptic protein; Acetylcholine receptor-associated 43 kDa protein; RAPsyn", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395986)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9185539", "class_list": "", "function": "Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0033130 acetylcholine receptor binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0031594 neuromuscular junction;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:1900075 positive regulation of neuromuscular synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O42393-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42398-1", "uniprot_id": [ { "id": "CAC1S_CHICK", "url": "https://www.uniprot.org/uniprot/O42398", "type": "external" } ], "mass": 32729.0, "length": 281, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha-1S", "gene_name": "CACNA1S", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CACNA1S", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha-1S; Voltage-gated calcium channel subunit alpha Cav1.1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0030315 T-tubule;GO:1990454 L-type voltage-gated calcium channel complex", "go_biological_process": "GO:0006936 muscle contraction;GO:0051209 release of sequestered calcium ion into cytosol;GO:0070588 calcium ion transmembrane transport;GO:0071313 cellular response to caffeine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O42398-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42400-1", "uniprot_id": [ { "id": "AXIN1_CHICK", "url": "https://www.uniprot.org/uniprot/O42400", "type": "external" } ], "mass": 94932.0, "length": 841, "protein_name": "Axin-1", "gene_name": "AXIN1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AXIN1; AXIN; AXN", "gene_names_refseq": "", "protein_names_uniprotkb": "Axin-1; Axis inhibition protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395786)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9230313", "class_list": "", "function": "Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0030877 beta-catenin destruction complex", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0048468 cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O42400-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42412-1", "uniprot_id": [ { "id": "IOD3_CHICK", "url": "https://www.uniprot.org/uniprot/O42412", "type": "external" } ], "mass": 28876.0, "length": 258, "protein_name": "Thyroxine 5-deiodinase", "gene_name": "DIO3", "organism": "Chicken", "refseq_name": "thyroxine 5-deiodinase", "refseq_ac": [ { "id": "NP_001116120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116120", "type": "external" } ], "gene_names_uniprotkb": "DIO3", "gene_names_refseq": "DIO3", "protein_names_uniprotkb": "Thyroxine 5-deiodinase; 1.21.99.3; 5DIII; DIOIII; Type 3 DI; Type III iodothyronine deiodinase", "protein_names_refseq": "5DIII; DIOIII; iodothyronine deiodinase 3; thyroxine 5-deiodinase; type 3 DI; type III iodothyronine deiodinase; type-III 5'-deiodinase", "tax_id": 9031, "disease": "", "pathway": " (gga:395939)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22771619;9389494", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: Y11273.1, SRR13267655.9099.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JAENSK010000215.1. On Mar 13, 2008 this sequence version replaced XP_426465.1. The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. As in mammals, studies in chicken show that this enzyme is involved in embryonic development. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2016]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; D3 are expressed in the choroid plexus and several sensory brain centers, [RefSeq, PubMed]; Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:9389494). Catalyzes the deiodination of L-thyroxine (T4) to 3,3',5'-triiodothyronine (rT3) and 3,5,3'-triiodothyronine (T3) to 3,3'-diiodothyronine (3,3'-T2) via inner-ring deiodination (IRD) (PubMed:9389494). Catalyzes the deiodination of rT3 to 3',5'-diiodothyronine (3',5'-T2), 3,3'-T2 to 3'-monoiodothyronine (3'-T1) and 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1) via IRD (By similarity). Catalyzes the deiodination of 3-T1 to L-thyronine (T0) via outer-ring deiodination (ORD) (By similarity). Catalyzes the tyrosyl ring deiodinations of 3,3',5,5'-tetraiodothyronamine, 3,3',5'-triiodothyronamine, 3,5,3'-triiodothyronamine, 3,5-diiodothyronamine, 3,3'-diiodothyronamine and 3-iodothyronamine (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.21.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.3", "type": "external" }, { "id": "1.21.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.21.99.4", "type": "external" } ], "go_molecular_function": "GO:0033798 thyroxine 5-deiodinase activity;GO:0004800 thyroxine 5'-deiodinase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0042404 thyroid hormone catabolic process;GO:0042446 hormone biosynthetic process;GO:0042403 thyroid hormone metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O42412-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O42479-1", "uniprot_id": [ { "id": "HEMH_CHICK", "url": "https://www.uniprot.org/uniprot/O42479", "type": "external" } ], "mass": 45430.0, "length": 402, "protein_name": "Ferrochelatase, mitochondrial", "gene_name": "FECH", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FECH", "gene_names_refseq": "", "protein_names_uniprotkb": "Ferrochelatase, mitochondrial; 4.98.1.1; Heme synthase; Protoheme ferro-lyase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:374020); (R-GGA-421984)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16121195;2915978;9808757", "class_list": "", "function": "Catalyzes the ferrous insertion into protoporphyrin IX., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0004325 ferrochelatase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006783 heme biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O42479-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57328-1", "uniprot_id": [ { "id": "FZD1_CHICK", "url": "https://www.uniprot.org/uniprot/O57328", "type": "external" } ], "mass": 65491.0, "length": 592, "protein_name": "Frizzled-1", "gene_name": "FZD1", "organism": "Chicken", "refseq_name": "frizzled-1 precursor", "refseq_ac": [ { "id": "NP_001025508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025508", "type": "external" } ], "gene_names_uniprotkb": "FZD1; FZ1", "gene_names_refseq": "FZD1; Fz-1; cFz-1", "protein_names_uniprotkb": "Frizzled-1; Fz-1; cFz-1", "protein_names_refseq": "7-transmembrane protein frizzled-1; frizzled family receptor 1; frizzled homolog 1; frizzled-1 precursor; frizzled-1", "tax_id": 9031, "disease": "", "pathway": " (gga:374062)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10781956;9598377", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: AF031830.1, SRR13267649.95163.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF031830.1. On Aug 8, 2005 this sequence version replaced XP_418648.1., [RefSeq]; Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9IA07", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0060070 canonical Wnt signaling pathway;GO:0035567 non-canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O57328-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57329-1", "uniprot_id": [ { "id": "FZD7_CHICK", "url": "https://www.uniprot.org/uniprot/O57329", "type": "external" } ], "mass": 62811.0, "length": 567, "protein_name": "Frizzled-7", "gene_name": "FZD7", "organism": "Chicken", "refseq_name": "frizzled-7 precursor", "refseq_ac": [ { "id": "NP_989552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989552", "type": "external" } ], "gene_names_uniprotkb": "FZD7; FZ7", "gene_names_refseq": "Chfz7; FZD7; Frz-7; Fz-7; cFz-7", "protein_names_uniprotkb": "Frizzled-7; Fz-7; cFz-7", "protein_names_refseq": "frizzled 7, seven transmembrane spanning receptor; frizzled family receptor 7; frizzled homolog 7; frizzled-7 precursor; frizzled-7", "tax_id": 9031, "disease": "", "pathway": " (gga:374060)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10781956;9598377", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: AF224317.1, AF031831.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000236.1. On Oct 18, 2021 this sequence version replaced NP_989552.1., [RefSeq]; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9IA04", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0060070 canonical Wnt signaling pathway;GO:0035567 non-canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O57329-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57337-1", "uniprot_id": [ { "id": "HES1_CHICK", "url": "https://www.uniprot.org/uniprot/O57337", "type": "external" } ], "mass": 31072.0, "length": 290, "protein_name": "Transcription factor HES-1", "gene_name": "HES1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HES1; HAIRY1", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor HES-1; C-HAIRY1; Hairy and enhancer of split 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9393857", "class_list": "", "function": "Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045665 negative regulation of neuron differentiation;GO:0009952 anterior/posterior pattern specification;GO:0050767 regulation of neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O57337-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57405-1", "uniprot_id": [ { "id": "TYRP1_CHICK", "url": "https://www.uniprot.org/uniprot/O57405", "type": "external" } ], "mass": 60595.0, "length": 535, "protein_name": "5,6-dihydroxyindole-2-carboxylic acid oxidase", "gene_name": "TYRP1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TYRP1", "gene_names_refseq": "", "protein_names_uniprotkb": "5,6-dihydroxyindole-2-carboxylic acid oxidase; 1.14.18.-; DHICA oxidase; TRP-1; TRP1; Tyrosinase-related protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9434144", "class_list": "", "function": "Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.18.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004503 tyrosinase activity", "go_cellular_component": "GO:0042470 melanosome;GO:0033162 melanosome membrane", "go_biological_process": "GO:0032438 melanosome organization;GO:0042438 melanin biosynthetic process;GO:0048023 positive regulation of melanin biosynthetic process;GO:0030318 melanocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O57405-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57424-1", "uniprot_id": [ { "id": "HYAS2_CHICK", "url": "https://www.uniprot.org/uniprot/O57424", "type": "external" } ], "mass": 63745.0, "length": 552, "protein_name": "Hyaluronan synthase 2", "gene_name": "HAS2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HAS2", "gene_names_refseq": "", "protein_names_uniprotkb": "Hyaluronan synthase 2; 2.4.1.212; CHAS2; HA synthase 2; Hyaluronate synthase 2; Hyaluronic acid synthase 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9442026", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (By similarity). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.212", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.212", "type": "external" } ], "go_molecular_function": "GO:0050501 hyaluronan synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0036302 atrioventricular canal development;GO:0000271 polysaccharide biosynthetic process;GO:0085029 extracellular matrix assembly;GO:0001570 vasculogenesis;GO:0035810 positive regulation of urine volume", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O57424-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57425-1", "uniprot_id": [ { "id": "HYAS3_CHICK", "url": "https://www.uniprot.org/uniprot/O57425", "type": "external" } ], "mass": 64653.0, "length": 574, "protein_name": "Hyaluronan synthase 3", "gene_name": "HAS3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HAS3", "gene_names_refseq": "", "protein_names_uniprotkb": "Hyaluronan synthase 3; 2.4.1.212; CHAS3; HA synthase 3; Hyaluronate synthase 3; Hyaluronic acid synthase 3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15592404;9442026", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (By similarity). This is one of three isoenzymes responsible for cellular hyaluronan synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1NU27", "ec_number_list": [ { "id": "2.4.1.212", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.212", "type": "external" } ], "go_molecular_function": "GO:0050501 hyaluronan synthase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0000271 polysaccharide biosynthetic process;GO:0085029 extracellular matrix assembly;GO:0030213 hyaluronan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O57425-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O57429-1", "uniprot_id": [ { "id": "UBP2_CHICK", "url": "https://www.uniprot.org/uniprot/O57429", "type": "external" } ], "mass": 40932.0, "length": 357, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 2", "gene_name": "USP2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "USP2; UBP41", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 2; 3.4.19.12; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9325273", "class_list": "", "function": "Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin-specific peptidase and isopeptidase activities. May play a role in the regulation of the circadian clock., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O57429-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73612-1", "uniprot_id": [ { "id": "EFNB1_CHICK", "url": "https://www.uniprot.org/uniprot/O73612", "type": "external" } ], "mass": 36859.0, "length": 334, "protein_name": "Ephrin-B1", "gene_name": "EFNB1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EFNB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephrin-B1; CEK5 ligand; CEK5-L", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395896)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9070326", "class_list": "", "function": "Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O73612-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73691-1", "uniprot_id": [ { "id": "EGR1_CHICK", "url": "https://www.uniprot.org/uniprot/O73691", "type": "external" } ], "mass": 21308.0, "length": 194, "protein_name": "Early growth response protein 1", "gene_name": "EGR1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EGR1; ZENK", "gene_names_refseq": "", "protein_names_uniprotkb": "Early growth response protein 1; EGR-1; Zinc finger protein ZENK", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9501495", "class_list": "", "function": "Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the expression of proteins that are involved in inflammatory processes (By similarity). Plays a role in regulating the expression of circadian clock genes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O73691-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73706-1", "uniprot_id": [ { "id": "CAC1B_CHICK", "url": "https://www.uniprot.org/uniprot/O73706", "type": "external" } ], "mass": 18327.0, "length": 159, "protein_name": "Voltage-dependent N-type calcium channel subunit alpha-1B", "gene_name": "CACNA1B", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CACNA1B", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-dependent N-type calcium channel subunit alpha-1B; CHCACHA1B; Voltage-gated calcium channel subunit alpha Cav2.2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9405708", "class_list": "", "function": "Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This alpha-1B subunit gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group. They are involved in pain signaling. Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons. Mediates Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005245 voltage-gated calcium channel activity", "go_cellular_component": "GO:0044305 calyx of Held;GO:0042734 presynaptic membrane;GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O73706-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73718-1", "uniprot_id": [ { "id": "TBX3_CHICK", "url": "https://www.uniprot.org/uniprot/O73718", "type": "external" } ], "mass": 46425.0, "length": 414, "protein_name": "T-box transcription factor TBX3", "gene_name": "TBX3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TBX3", "gene_names_refseq": "", "protein_names_uniprotkb": "T-box transcription factor TBX3; T-box protein 3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "9550719;9655805", "class_list": "", "function": "Transcriptional repressor involved in developmental processes. Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes. Probably plays a role in limb pattern formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0001708 cell fate specification;GO:0032275 luteinizing hormone secretion;GO:0046884 follicle-stimulating hormone secretion;GO:0030540 female genitalia development;GO:0048332 mesoderm morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O73718-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73884-1", "uniprot_id": [ { "id": "PHOP1_CHICK", "url": "https://www.uniprot.org/uniprot/O73884", "type": "external" } ], "mass": 30443.0, "length": 268, "protein_name": "Phosphoethanolamine/phosphocholine phosphatase", "gene_name": "PHOSPHO1", "organism": "Chicken", "refseq_name": "phosphoethanolamine/phosphocholine phosphatase", "refseq_ac": [ { "id": "NP_990176", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990176", "type": "external" } ], "gene_names_uniprotkb": "PHOSPHO1", "gene_names_refseq": "PHOSPHO1", "protein_names_uniprotkb": "Phosphoethanolamine/phosphocholine phosphatase; 3.1.3.75; 3X11A", "protein_names_refseq": "3X11A; phosphatase, orphan 1; phosphoethanolamine/phosphocholine phosphatase; putative phosphatase", "tax_id": 9031, "disease": "", "pathway": " (gga:395650)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15050893;20053388;9990301", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ006529.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ006529.1., [RefSeq]; In conclusion, this study has disclosed that PHOSPHO1 expression mirrors that of TNAP during embryonic bone development and that PHOSPHO1 contributes to bone mineralization in developing chick long bones., [RefSeq, PubMed]; PHOSPHO1-a member of the large haloacid dehalogenase superfamily of hydrolases-is localized to sites of mineralisation in both cartilage and bone, [RefSeq, PubMed]; Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (By similarity). Involved in the generation of inorganic phosphate for bone mineralization (PubMed:15050893)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.75", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" } ], "go_molecular_function": "GO:0052731 phosphocholine phosphatase activity;GO:0052732 phosphoethanolamine phosphatase activity;GO:0046872 metal ion binding;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0065010 extracellular membrane-bounded organelle;GO:0031012 extracellular matrix;GO:1903561 extracellular vesicle", "go_biological_process": "GO:0035630 bone mineralization involved in bone maturation;GO:0030500 regulation of bone mineralization;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O73884-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O73895-1", "uniprot_id": [ { "id": "TPSN_CHICK", "url": "https://www.uniprot.org/uniprot/O73895", "type": "external" } ], "mass": 45456.0, "length": 430, "protein_name": "Tapasin", "gene_name": "TAPBP", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TAPBP; B-TAPBPL", "gene_names_refseq": "", "protein_names_uniprotkb": "Tapasin; TAP-associated protein; TAP-binding protein; TPN; TPSN", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10079297;3141149", "class_list": "", "function": "Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O73886;O73887;O93604", "ec_number_list": [], "go_molecular_function": "GO:0023024 MHC class I protein complex binding;GO:0062061 TAP complex binding", "go_cellular_component": "GO:0042824 MHC class I peptide loading complex", "go_biological_process": "GO:0002502 peptide antigen assembly with MHC class I protein complex", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "O73895-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O93295-1", "uniprot_id": [ { "id": "ENTP8_CHICK", "url": "https://www.uniprot.org/uniprot/O93295", "type": "external" } ], "mass": 54035.0, "length": 493, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 8", "gene_name": "ENTPD8", "organism": "Chicken", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 8", "refseq_ac": [ { "id": "NP_989578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989578", "type": "external" } ], "gene_names_uniprotkb": "ENTPD8", "gene_names_refseq": "ENTPD1; ENTPD8; ecto-ATPase", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 8; 3.6.1.5; E-NTPDase 8; Liver ecto-ATP diphosphohydrolase; NTPDase 8; NTPDase8", "protein_names_refseq": "E-NTPDase 8; NTPDase 8; NTPDase8; ectonucleoside triphosphate diphosphohydrolase 1; ectonucleoside triphosphate diphosphohydrolase 8; liver ecto-ATP diphosphohydrolase; nucleoside triphosphate diphosphohydrolase 8", "tax_id": 9031, "disease": "", "pathway": " (gga:374095)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11985621;16101300;20000380;9295305;9632655", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888536.53827.1, SRR13267659.120311.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05341171 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000308.1. On Sep 23, 2021 this sequence version replaced NP_989578.2., [RefSeq]; Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity (PubMed:11985621). Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (PubMed:11985621, PubMed:16101300). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:11985621, PubMed:16101300). This activity contributes to the regulation of extracellular levels of nucleotides (PubMed:11985621, PubMed:16101300). Hydrolyzes ATP and ADP and prefers triphosphonucleosides and adenine over uracil as substrates (PubMed:11985621, PubMed:16101300). Does not hydrolyzes AMP (PubMed:11985621, PubMed:16101300)., [UniProtKB, PubMed, PubMed]; The stability of chicken nucleoside triphosphate diphosphohydrolase 8 requires both of its transmembrane domains, [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q90X66", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0004382 GDP phosphatase activity;GO:0043262 ADP phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0009203 ribonucleoside triphosphate catabolic process;GO:0009191 ribonucleoside diphosphate catabolic process;GO:0009134 nucleoside diphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "O93295-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O93319-1", "uniprot_id": [ { "id": "CAD11_CHICK", "url": "https://www.uniprot.org/uniprot/O93319", "type": "external" } ], "mass": 87573.0, "length": 792, "protein_name": "Cadherin-11", "gene_name": "CDH11", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CDH11", "gene_names_refseq": "", "protein_names_uniprotkb": "Cadherin-11", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:415797)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly. Involved in the regulation of cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0098609 cell-cell adhesion;GO:0030199 collagen fibril organization;GO:0007043 cell-cell junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "O93319-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O93367-1", "uniprot_id": [ { "id": "TLX3_CHICK", "url": "https://www.uniprot.org/uniprot/O93367", "type": "external" } ], "mass": 32369.0, "length": 297, "protein_name": "T-cell leukemia homeobox protein 3", "gene_name": "TLX3", "organism": "Chicken", "refseq_name": "T-cell leukemia homeobox protein 3", "refseq_ac": [ { "id": "NP_001392780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001392780", "type": "external" } ], "gene_names_uniprotkb": "TLX3; HOX11L2", "gene_names_refseq": "TLX-3; TLX3", "protein_names_uniprotkb": "T-cell leukemia homeobox protein 3; Homeobox TLX-3; Homeobox protein Hox-11L2", "protein_names_refseq": "T-cell leukemia homeobox protein 3; homeobox TLX-3; homeobox protein Hox-11L2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15922575;18835836;9651221", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: ERR7564013.48831.1, ERR7564012.28858.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000256.1. On or before May 4, 2022 this sequence version replaced XP_040503014.1, XP_040538808.1., [RefSeq]; Seems to be involved in the development of cranial sensory innervation from peripheral ganglia., [UniProtKB]; TLX3 gene expression is an independent risk factor predicting poor survival in childhood T-cell acute lymphoblastic leukemia., [RefSeq, PubMed]; Tlx-3, in addition to being required for proper formation of somatic as well as visceral sensory neurons in the trigeminal and solitary nuclei, respectively, is sufficient for proper formation of special somatic sensory neurons in vestibular nuclei, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O93367-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O93436-1", "uniprot_id": [ { "id": "STAM2_CHICK", "url": "https://www.uniprot.org/uniprot/O93436", "type": "external" } ], "mass": 52407.0, "length": 468, "protein_name": "Signal transducing adapter molecule 2", "gene_name": "STAM2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "STAM2; EAST", "gene_names_refseq": "", "protein_names_uniprotkb": "Signal transducing adapter molecule 2; Epidermal growth factor receptor-associated protein with SH3 and TAM domain; STAM-2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:424317)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "9694904;9720929;9801161", "class_list": "", "function": "Involved in intracellular signal transduction mediated by EGF. As a protein associated with focal adhesions and actin filaments, it may play a role in EGF receptor-stimulated cytoskeletal reorganization. The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0035091 phosphatidylinositol binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0031901 early endosome membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0007165 signal transduction;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "O93436-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O93505-1", "uniprot_id": [ { "id": "TYRP2_CHICK", "url": "https://www.uniprot.org/uniprot/O93505", "type": "external" } ], "mass": 59314.0, "length": 521, "protein_name": "L-dopachrome tautomerase", "gene_name": "DCT", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DCT; TYRP2", "gene_names_refseq": "", "protein_names_uniprotkb": "L-dopachrome tautomerase; 5.3.3.12; DCT; DT; L-dopachrome Delta-isomerase; TRP-2; TRP2; Tyrosinase-related protein 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395775)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9756992", "class_list": "", "function": "Plays a role in melanin biosynthesis. Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA)., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016491 oxidoreductase activity;GO:0004167 dopachrome isomerase activity", "go_cellular_component": "GO:0042470 melanosome;GO:0033162 melanosome membrane", "go_biological_process": "GO:0002052 positive regulation of neuroblast proliferation;GO:0048066 developmental pigmentation;GO:0021847 ventricular zone neuroblast division;GO:0006583 melanin biosynthetic process from tyrosine", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O93505-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O93510-1", "uniprot_id": [ { "id": "GELS_CHICK", "url": "https://www.uniprot.org/uniprot/O93510", "type": "external" } ], "mass": 85832.0, "length": 778, "protein_name": "Gelsolin", "gene_name": "GSN", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GSN", "gene_names_refseq": "", "protein_names_uniprotkb": "Gelsolin; ADF; Actin-depolymerizing factor; Brevin; Homogenin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395774)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9736748", "class_list": "", "function": "Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (By similarity). Plays a role in ciliogenesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007417 central nervous system development;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0060271 cilium assembly;GO:0051014 actin filament severing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "O93510-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "O93525-1", "uniprot_id": [ { "id": "NOGG_CHICK", "url": "https://www.uniprot.org/uniprot/O93525", "type": "external" } ], "mass": 25596.0, "length": 223, "protein_name": "Noggin", "gene_name": "NOG", "organism": "Chicken", "refseq_name": "noggin precursor", "refseq_ac": [ { "id": "NP_989454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989454", "type": "external" } ], "gene_names_uniprotkb": "NOG", "gene_names_refseq": "NOG", "protein_names_uniprotkb": "Noggin; cNoggin", "protein_names_refseq": "cNoggin; noggin precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:373912)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15269169;15456730;15766751;24038612;26173507;9769170;9927590", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: HAEK01078195.1, HAEK01154049.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000317.1. On Dec 3, 2021 this sequence version replaced NP_989454.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Inhibitor of bone morphogenetic proteins (BMP) signaling. Controls somitogenesis by sequestering the BMP-4 activity which in turn differentiates distinct subtypes of the mesoderm along the mediolateral axis., [UniProtKB]; Noggin and Shh are both required in order to change the future amnion into a feather-bearing skin., [RefSeq, PubMed]; Noggin overexpression inhibits G1/S transition and blocking G1/S abrogates Bone Morphogenetic Proteins-induced delamination; moreover, transcription of Wnt1 is stimulated by BMP and by the developing somites, [RefSeq, PubMed]; Noggin overexpression resulted in disrupted cord organization, and dilated sinusoidal space, eventually leading to increased apoptosis and failed hepatocyte differentiation., [RefSeq, PubMed]; Results show that inhibition of BMP4 by noggin results in a reduction of embryonic blood vessels, [RefSeq, PubMed]; The expression level of Noggin (together with other cartilage expressed BMP antagonists) is a landmark in the transition between the chondrogenic and fibrogenic response to BMPs in the differentiation of connective tissues., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "O73674", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0051151 negative regulation of smooth muscle cell differentiation;GO:0001649 osteoblast differentiation;GO:0009953 dorsal/ventral pattern formation;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "O93525-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00337-1", "uniprot_id": [ { "id": "LDHB_CHICK", "url": "https://www.uniprot.org/uniprot/P00337", "type": "external" } ], "mass": 36318.0, "length": 333, "protein_name": "L-lactate dehydrogenase B chain", "gene_name": "LDHB", "organism": "Chicken", "refseq_name": "L-lactate dehydrogenase B chain", "refseq_ac": [ { "id": "NP_989508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989508", "type": "external" } ], "gene_names_uniprotkb": "LDHB", "gene_names_refseq": "LDHB", "protein_names_uniprotkb": "L-lactate dehydrogenase B chain; 1.1.1.27; LDH-B", "protein_names_refseq": "L-lactate dehydrogenase B chain", "tax_id": 9031, "disease": "", "pathway": " (gga:373997); (R-GGA-373920); (R-GGA-70268)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "16830864;2243792;32416791", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CO635772.1, HAEK01106107.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1., [RefSeq]; Altered expression of lactate dehydrogenase and monocarboxylate transporter involved in lactate metabolism in broiler wooden breast., [RefSeq, PubMed]; Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)., [UniProtKB, UniProtKB]; The expression of LDHA and LDHB in the glycogen body of chick embryos and adult chickens is reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O93362;Q548X0", "ec_number_list": [ { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004459 L-lactate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005829 cytosol;GO:0045121 membrane raft", "go_biological_process": "GO:0006089 lactate metabolic process;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P00337-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00340-1", "uniprot_id": [ { "id": "LDHA_CHICK", "url": "https://www.uniprot.org/uniprot/P00340", "type": "external" } ], "mass": 36514.0, "length": 332, "protein_name": "L-lactate dehydrogenase A chain", "gene_name": "LDHA", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LDHA", "gene_names_refseq": "", "protein_names_uniprotkb": "L-lactate dehydrogenase A chain; 1.1.1.27; LDH-A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396221); (R-GGA-373920)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "2243792", "class_list": "", "function": "Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" } ], "go_molecular_function": "GO:0004459 L-lactate dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006089 lactate metabolic process;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P00340-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00368-1", "uniprot_id": [ { "id": "DHE3_CHICK", "url": "https://www.uniprot.org/uniprot/P00368", "type": "external" } ], "mass": 55712.0, "length": 503, "protein_name": "Glutamate dehydrogenase 1, mitochondrial", "gene_name": "GLUD1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GLUD1; GLUD", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutamate dehydrogenase 1, mitochondrial; 1.4.1.3; GDH 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "4735574", "class_list": "", "function": "Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0004352 glutamate dehydrogenase (NAD+) activity;GO:0004353 glutamate dehydrogenase [NAD(P)+] activity;GO:0004354 glutamate dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006541 glutamine metabolic process;GO:0006538 L-glutamate catabolic process;GO:0072350 tricarboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P00368-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00378-1", "uniprot_id": [ { "id": "DYR_CHICK", "url": "https://www.uniprot.org/uniprot/P00378", "type": "external" } ], "mass": 21650.0, "length": 189, "protein_name": "Dihydrofolate reductase", "gene_name": "DHFR", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DHFR", "gene_names_refseq": "", "protein_names_uniprotkb": "Dihydrofolate reductase; 1.5.1.3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "1510919;6766736;8670138", "class_list": "", "function": "Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. May bind to mRNA., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.3", "type": "external" } ], "go_molecular_function": "GO:0004146 dihydrofolate reductase activity;GO:0003729 mRNA binding;GO:0050661 NADP binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0006730 one-carbon metabolic process;GO:0046655 folic acid metabolic process;GO:0031427 response to methotrexate;GO:0046653 tetrahydrofolate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P00378-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00548-1", "uniprot_id": [ { "id": "KPYM_CHICK", "url": "https://www.uniprot.org/uniprot/P00548", "type": "external" } ], "mass": 58015.0, "length": 530, "protein_name": "Pyruvate kinase PKM", "gene_name": "PKM", "organism": "Chicken", "refseq_name": "pyruvate kinase PKM", "refseq_ac": [ { "id": "NP_990800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990800", "type": "external" } ], "gene_names_uniprotkb": "PKM", "gene_names_refseq": "PKLR; PKM2; PKM", "protein_names_uniprotkb": "Pyruvate kinase PKM; 2.7.1.40", "protein_names_refseq": "pyruvate kinase M1/2; pyruvate kinase PKM; pyruvate kinase muscle isozyme; pyruvate kinase, muscle", "tax_id": 9031, "disease": "", "pathway": " (gga:396456); (R-GGA-352882)", "pathway_count": 2, "publication_count": 13, "publication_id_list": "16287166;2981634;2985560;3539098;3885220;4463937;6303388;6574503;7629021;7768978;7916593;8182283;9434147", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: J00903.1, SRR13267659.281108.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992437 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000245.1., [RefSeq]; Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016301 kinase activity;GO:0030955 potassium ion binding;GO:0004743 pyruvate kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "P00548-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00565-1", "uniprot_id": [ { "id": "KCRM_CHICK", "url": "https://www.uniprot.org/uniprot/P00565", "type": "external" } ], "mass": 43328.0, "length": 381, "protein_name": "Creatine kinase M-type", "gene_name": "CKM", "organism": "Chicken", "refseq_name": "creatine kinase M-type", "refseq_ac": [ { "id": "NP_990838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990838", "type": "external" } ], "gene_names_uniprotkb": "CKM", "gene_names_refseq": "CKM; CPK-M; LOC107051134", "protein_names_uniprotkb": "Creatine kinase M-type; 2.7.3.2; CPK-M; Creatine kinase M chain; Creatine phosphokinase M-type; M-CK", "protein_names_refseq": "B-creatine kinase; M-CK; creatine kinase M chain; creatine kinase M-type; creatine kinase, M-type; creatine kinase, muscle; creatine phosphokinase M-type", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "6091045;6096363;8525081", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X00954.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X00954.1. On Aug 30, 2004 this sequence version replaced XP_427851.1., [RefSeq]; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8525081). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" } ], "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol", "go_biological_process": "GO:0046314 phosphocreatine biosynthetic process;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P00565-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P00793-1", "uniprot_id": [ { "id": "PEPA_CHICK", "url": "https://www.uniprot.org/uniprot/P00793", "type": "external" } ], "mass": 40432.0, "length": 367, "protein_name": "Pepsin A", "gene_name": "PGA", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PGA", "gene_names_refseq": "", "protein_names_uniprotkb": "Pepsin A; 3.4.23.1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6617663", "class_list": "", "function": "Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004190 aspartic-type endopeptidase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P00793-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01014-1", "uniprot_id": [ { "id": "OVALY_CHICK", "url": "https://www.uniprot.org/uniprot/P01014", "type": "external" } ], "mass": 43772.0, "length": 388, "protein_name": "Ovalbumin-related protein Y", "gene_name": "SERPINB14B", "organism": "Chicken", "refseq_name": "ovalbumin-related protein Y", "refseq_ac": [ { "id": "NP_001026172", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026172", "type": "external" } ], "gene_names_uniprotkb": "SERPINB14B; Y", "gene_names_refseq": "OVALY; SERPINB14B; SERPINB3; oval-Y", "protein_names_uniprotkb": "Ovalbumin-related protein Y; Gene Y protein", "protein_names_refseq": "clade (ovalbumin); gene Y protein; member 14B; ovalbumin Y; ovalbumin-related Y; ovalbumin-related protein Y; serpin peptidase inhibitor, clade B (ovalbumin), member 3", "tax_id": 9031, "disease": "", "pathway": " (gga:420897); (R-GGA-6798695); (R-GGA-8939242)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "16428832;18950868;25436390;26157071;7122240", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: AB288388.1, AB288389.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA103992290 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from J00922.1. On Aug 8, 2005 this sequence version replaced XP_418983.1., [RefSeq]; Ovalbumin Y is a unique chimeric glycoprotein having an amino acid sequence similar to that of ovalbumin, [RefSeq, PubMed]; Recent data have revealed a possible role of this protein in early embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P01014-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01038-1", "uniprot_id": [ { "id": "CYT_CHICK", "url": "https://www.uniprot.org/uniprot/P01038", "type": "external" } ], "mass": 15287.0, "length": 139, "protein_name": "Cystatin", "gene_name": "", "organism": "Chicken", "refseq_name": "cystatin precursor", "refseq_ac": [ { "id": "NP_990831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990831", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "CST3", "protein_names_uniprotkb": "Cystatin; Egg-white cystatin; Ovocystatin", "protein_names_refseq": "cystatin precursor; egg-white cystatin; ovocystatin", "tax_id": 9031, "disease": "", "pathway": " (gga:396497)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "15336605;20085381;2721673;2793849;3191914;6409085;6662498;6712597;8263912", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CN210879.1, CN210880.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000062.1. On Jan 19, 2011 this sequence version replaced NP_990831.1. Sequence Note: This RefSeq record was created from transcripts of different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; In calvarial bone explants egg white cystatin decreases calcium release into the medium significantly., [RefSeq, PubMed]; The I108T mutant, which exhibited larger secondary structural fluctuations and hydrophobic core expanding tendency compared with the wild-type chicken cystatin, is a new amyloidogenic form of chicken cystatin., [RefSeq, PubMed]; This protein binds tightly to and inhibits a variety of thiol proteases including ficin, papain, and cathepsins B, C, H, and L. Although isolated from egg white, it is also present in serum., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031982 vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P01038-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01295-1", "uniprot_id": [ { "id": "GRP_CHICK", "url": "https://www.uniprot.org/uniprot/P01295", "type": "external" } ], "mass": 17807.0, "length": 164, "protein_name": "Gastrin-releasing peptide", "gene_name": "GRP", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GRP", "gene_names_refseq": "", "protein_names_uniprotkb": "Gastrin-releasing peptide; GRP-10; GRP; Proventricular peptide", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15592404;2297533;7215543", "class_list": "", "function": "Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Stimulates pancreatic protein and fluid secretion, and increases acid secretion from the avian proventriculus (PubMed:2297533)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A3Q2U7K9", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0034774 secretory granule lumen", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:2000987 positive regulation of behavioral fear response;GO:0090277 positive regulation of peptide hormone secretion;GO:1900738 positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P01295-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P01994-1", "uniprot_id": [ { "id": "HBA_CHICK", "url": "https://www.uniprot.org/uniprot/P01994", "type": "external" } ], "mass": 15429.0, "length": 142, "protein_name": "Hemoglobin subunit alpha-A", "gene_name": "HBAA", "organism": "Chicken", "refseq_name": "hemoglobin subunit alpha-A", "refseq_ac": [ { "id": "NP_001004376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004376", "type": "external" } ], "gene_names_uniprotkb": "HBAA", "gene_names_refseq": "HBA1; HBAA; alpha-A-globin", "protein_names_uniprotkb": "Hemoglobin subunit alpha-A; Alpha-A-globin; Hemoglobin alpha-A chain", "protein_names_refseq": "adult alpha A globin; alpha-A globin; hemoglobin alpha, subunit A; hemoglobin alpha, subunit?A; hemoglobin alpha-A chain; hemoglobin subunit alpha-A; hemoglobin, alpha 1", "tax_id": 9031, "disease": "", "pathway": " (gga:416652)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11157800;1656392;18083574;19693775;25239823;25860507;4567660;6251083;6253930;6273837;6300093;6894907;7057930;714170", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DR427745.1, AL584093.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. On Sep 17, 2004 this sequence version replaced XP_414949.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Epigenetic mechanisms are necessary for in vivo chicken alpha-globin gene switching through differential gene silencing of the embryonic alpha-globin gene in order to allow proper activation of adult alpha-globin genes., [RefSeq, PubMed]; Involved in oxygen transport from the lung to the various peripheral tissues., [UniProtKB]; These results suggest that the Upstream Enhancer Element activity contributes to the positioning of a nucleosome that is necessary for the alpha-globin 3' enhancer activation, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9PWP3", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P01994-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02001-1", "uniprot_id": [ { "id": "HBAD_CHICK", "url": "https://www.uniprot.org/uniprot/P02001", "type": "external" } ], "mass": 15695.0, "length": 141, "protein_name": "Hemoglobin subunit alpha-D", "gene_name": "HBAD", "organism": "Chicken", "refseq_name": "hemoglobin subunit alpha-D", "refseq_ac": [ { "id": "NP_001004375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004375", "type": "external" } ], "gene_names_uniprotkb": "HBAD", "gene_names_refseq": "HBA2; HBAD; HBM", "protein_names_uniprotkb": "Hemoglobin subunit alpha-D; Alpha-D-globin; Hemoglobin alpha-D chain", "protein_names_refseq": "adult alpha D globin; alpha-D-globin; hemoglobin alpha-D chain; hemoglobin subunit alpha-D; hemoglobin subunit mu; hemoglobin, alpha 2", "tax_id": 9031, "disease": "", "pathway": " (gga:416651)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "10037733;11157800;1225908;15156557;1656392;19120022;21337627;6273837;6300093;7054172", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01000114.1, AL586558.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. On Sep 17, 2004 this sequence version replaced XP_414948.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; In avian erythroblastosis virus-transformed chicken erythroleukaemic cells, where globin gene expression is abortive, the whole domain of alpha-globin genes is transcribed for about 33 kb in the globin direction and this RNA is part of the nuclear matrix, [RefSeq, PubMed]; In this model, the deoxy hemoglobin D associates noncooperatively to give a linear oligomeric chain with an equilibrium association constant of 1.42 x 10(4) M(-1) at 20 degrees C for each step., [RefSeq, PubMed]; Involved in oxygen transport from the lung to the various peripheral tissues., [UniProtKB]; Spatial organization of the chicken HBA2 and HBA1 gene domains is different in erythroid and non-erythroid cells., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q549K7;Q78AJ9", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P02001-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02007-1", "uniprot_id": [ { "id": "HBPI_CHICK", "url": "https://www.uniprot.org/uniprot/P02007", "type": "external" } ], "mass": 15709.0, "length": 142, "protein_name": "Hemoglobin subunit pi", "gene_name": "", "organism": "Chicken", "refseq_name": "hemoglobin subunit pi", "refseq_ac": [ { "id": "NP_001004374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004374", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "HBAP; HBZ", "protein_names_uniprotkb": "Hemoglobin subunit pi; Hemoglobin pi chain; Hemoglobin pi' chain; Pi-globin", "protein_names_refseq": "embryonic alpha-globin pi-prime; hemoglobin alpha, subunit pi; hemoglobin pi chain; hemoglobin pi' chain; hemoglobin subunit pi; hemoglobin, zeta; pi-globin", "tax_id": 9031, "disease": "", "pathway": " (gga:416650)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11157800;15156557;21954598;22139578;6157691;6572397", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AL586168.1, AL586571.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992428 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. On Sep 17, 2004 this sequence version replaced XP_414947.1., [RefSeq]; In avian erythroblastosis virus-transformed chicken erythroleukaemic cells, where globin gene expression is abortive, the whole domain of alpha-globin genes is transcribed for about 33 kb in the globin direction and this RNA is part of the nuclear matrix, [RefSeq, PubMed]; Inactivation of the pi gene in erythroblasts of adult lineage is not mediated by packaging of the embryonic part of the alpha-globin gene domain into a repressive heterochromatin-like structure, [RefSeq, PubMed]; Suppression of the gene pi activity in erythroid cells of adult lineage correlates with the decrease of the histone acetylation level within the embryonic subdomain of the alpha-globin gene domain., [RefSeq, PubMed]; The pi' chain is the counterpart of the alpha chain in the major early embryonic hemoglobin P., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q78AK0", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P02007-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02127-1", "uniprot_id": [ { "id": "HBRH_CHICK", "url": "https://www.uniprot.org/uniprot/P02127", "type": "external" } ], "mass": 16589.0, "length": 147, "protein_name": "Hemoglobin subunit rho", "gene_name": "", "organism": "Chicken", "refseq_name": "hemoglobin subunit rho", "refseq_ac": [ { "id": "NP_001004390", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004390", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "HBB-R; HBBR; HBG1", "protein_names_uniprotkb": "Hemoglobin subunit rho; Hemoglobin rho chain; Rho-globin", "protein_names_refseq": "hemoglobin rho chain; hemoglobin subunit rho; hemoglobin, gamma A; rho-globin", "tax_id": 9031, "disease": "", "pathway": " (gga:419079)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "6170981;6313671;7240154;8307571", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: V00412.1, AL586369.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000032.1. On Sep 17, 2004 this sequence version replaced XP_417271.1., [RefSeq]; The rho chain is the major early embryonic beta-type hemoglobin chain., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P02127-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02128-1", "uniprot_id": [ { "id": "HBE_CHICK", "url": "https://www.uniprot.org/uniprot/P02128", "type": "external" } ], "mass": 16603.0, "length": 147, "protein_name": "Hemoglobin subunit epsilon", "gene_name": "HBE", "organism": "Chicken", "refseq_name": "hemoglobin subunit epsilon", "refseq_ac": [ { "id": "NP_001075173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075173", "type": "external" } ], "gene_names_uniprotkb": "HBE", "gene_names_refseq": "HBBE; HBE", "protein_names_uniprotkb": "Hemoglobin subunit epsilon; Epsilon-globin; Hemoglobin epsilon chain", "protein_names_refseq": "epsilon-globin; hemoglobin epsilon chain; hemoglobin subunit epsilon", "tax_id": 9031, "disease": "", "pathway": " (gga:107049060); (R-GGA-1237044); (R-GGA-1247673); (R-GGA-2168880); (R-GGA-6798695); (R-GGA-9707564); (R-GGA-9707616)", "pathway_count": 7, "publication_count": 5, "publication_id_list": "21337627;6313671;7054171;7054172;8307571", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: J00861.1, HAEL01013666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2812691, SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000032.1. On Sep 23, 2021 this sequence version replaced NP_001075173.2., [RefSeq]; Beta-type chain found in early embryos., [UniProtKB]; In this model, the deoxy hemoglobin D associates noncooperatively to give a linear oligomeric chain with an equilibrium association constant of 1.42 x 10(4) M(-1) at 20 degrees C for each step., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P02128-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02197-1", "uniprot_id": [ { "id": "MYG_CHICK", "url": "https://www.uniprot.org/uniprot/P02197", "type": "external" } ], "mass": 17422.0, "length": 154, "protein_name": "Myoglobin", "gene_name": "MB", "organism": "Chicken", "refseq_name": "myoglobin", "refseq_ac": [ { "id": "NP_001161224", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161224", "type": "external" } ], "gene_names_uniprotkb": "MB", "gene_names_refseq": "MB", "protein_names_uniprotkb": "Myoglobin; 1.11.1.-; 1.7.-.-; Nitrite reductase MB; Pseudoperoxidase MB", "protein_names_refseq": "myoglobin; nitrite reductase MB; pseudoperoxidase MB", "tax_id": 9031, "disease": "", "pathway": " (gga:418056); (R-GGA-8981607)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "1169972;3427916;6838896", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01035439.1, HAEK01131718.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Nov 19, 2009 this sequence version replaced XP_416292.1., [RefSeq]; Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand. Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide. Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02198", "ec_number_list": [ { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "1.7.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0004601 peroxidase activity;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0016528 sarcoplasm", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0019430 removal of superoxide radicals;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P02197-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02263-1", "uniprot_id": [ { "id": "H2A4_CHICK", "url": "https://www.uniprot.org/uniprot/P02263", "type": "external" } ], "mass": 13940.0, "length": 129, "protein_name": "Histone H2A-IV", "gene_name": "", "organism": "Chicken", "refseq_name": "histone H2A-IV", "refseq_ac": [ { "id": "NP_001072943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072943", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "2A-I; H2A-I; H2AC31; H2A; HIST1H2A4; HIST2H2AC", "protein_names_uniprotkb": "Histone H2A-IV", "protein_names_refseq": "histone H2A-IV; histone cluster 1, H2A, IV (similar to human histone cluster 2, class H2A, member C); histone cluster 2, H2ac", "tax_id": 9031, "disease": "", "pathway": " (gga:100858459); (gga:101749238); (gga:404299); (gga:417955); (gga:427881); (gga:427891); (gga:427895); (R-GGA-212300); (R-GGA-2299718); (R-GGA-2559580); (R-GGA-427413); (R-GGA-5250924); (R-GGA-5689901); (R-GGA-606279); (R-GGA-68616); (R-GGA-73728); (R-GGA-73772); (R-GGA-8936459); (R-GGA-9018519); (R-GGA-9764725); (R-GGA-9841922); (R-GGA-9843940); (R-GGA-9843970); (R-GGA-9909649); (R-GGA-9940951); (R-GGA-9943411); (R-GGA-9943962); (R-GGA-9970672)", "pathway_count": 28, "publication_count": 6, "publication_id_list": "12450536;1946434;2713375;4000938;6269072;667168", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: BX275918.4, BX275917.4 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Dec 9, 2006 this sequence version replaced XP_001233162.1., [RefSeq]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P02263-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02272-1", "uniprot_id": [ { "id": "H2AV_CHICK", "url": "https://www.uniprot.org/uniprot/P02272", "type": "external" } ], "mass": 13509.0, "length": 128, "protein_name": "Histone H2A.V", "gene_name": "H2AZ2", "organism": "Chicken", "refseq_name": "histone H2A.V", "refseq_ac": [ { "id": "NP_001383537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383537", "type": "external" } ], "gene_names_uniprotkb": "H2AZ2; H2AF", "gene_names_refseq": "H2A.F/Z; H2A.F; H2AFV; H2AF; H2AZ2", "protein_names_uniprotkb": "Histone H2A.V; H2A.F/Z", "protein_names_refseq": "H2A histone family, member V; histone H2A.V", "tax_id": 9031, "disease": "", "pathway": " (gga:426617)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15983376;16204459;2493634;6574451", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU409494.1, BU415330.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992432, SAMEA103992484 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU415330.1 and BU137764.1. On or before Oct 25, 2021 this sequence version replaced XP_015128745.1, XP_040545450.1., [RefSeq]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P02272-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02504-1", "uniprot_id": [ { "id": "CRYAA_CHICK", "url": "https://www.uniprot.org/uniprot/P02504", "type": "external" } ], "mass": 19787.0, "length": 173, "protein_name": "Alpha-crystallin A chain", "gene_name": "CRYAA", "organism": "Chicken", "refseq_name": "alpha-crystallin A chain", "refseq_ac": [ { "id": "NP_001025968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025968", "type": "external" } ], "gene_names_uniprotkb": "CRYAA", "gene_names_refseq": "CRYAA; cHsp25", "protein_names_uniprotkb": "Alpha-crystallin A chain", "protein_names_refseq": "alpha-crystallin A chain; alphaA-crystallin", "tax_id": 9031, "disease": "", "pathway": " (gga:418546)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26719333;3678835;6723655", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: EF408909.1, BU113558.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992660 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from EF408909.1. On Aug 8, 2005 this sequence version replaced XP_416753.1., [RefSeq]; Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf., [RefSeq, PubMed]; Contributes to the transparency and refractive index of the lens. May act as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070062 extracellular exosome", "go_biological_process": "GO:0032387 negative regulation of intracellular transport;GO:0043066 negative regulation of apoptotic process;GO:0051260 protein homooligomerization;GO:0007601 visual perception;GO:0009408 response to heat", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P02504-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02521-1", "uniprot_id": [ { "id": "ARLY1_CHICK", "url": "https://www.uniprot.org/uniprot/P02521", "type": "external" } ], "mass": 50796.0, "length": 466, "protein_name": "Delta-1 crystallin", "gene_name": "ASL1", "organism": "Chicken", "refseq_name": "delta-1 crystallin", "refseq_ac": [ { "id": "NP_990832", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990832", "type": "external" } ], "gene_names_uniprotkb": "ASL1", "gene_names_refseq": "ASL1; ASL; CRYD1; D-CRY", "protein_names_uniprotkb": "Delta-1 crystallin; Delta crystallin I", "protein_names_refseq": "crystallin delta 1; delta crystallin I; delta-1 crystallin; delta-crystallin 1; delta1-crystallin", "tax_id": 9031, "disease": "", "pathway": " (gga:396498); (R-GGA-187630)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "22461196;2987831;3839507;4018032;6418730;6547670;6585817;9792920", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01006490.1, J00843.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000323.1. On Feb 21, 2015 this sequence version replaced NP_990832.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles., [UniProtKB]; Embryonic chick pituitary gland consists of two different regions where delta-crystallin and Lhx3 are expressed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90814", "ec_number_list": [], "go_molecular_function": "GO:0004056 argininosuccinate lyase activity;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006525 arginine metabolic process;GO:0042450 L-arginine biosynthetic process via ornithine", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P02521-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02604-1", "uniprot_id": [ { "id": "MLE1_CHICK", "url": "https://www.uniprot.org/uniprot/P02604", "type": "external" } ], "mass": 20899.0, "length": 192, "protein_name": "Myosin light chain 1, skeletal muscle isoform", "gene_name": "", "organism": "Chicken", "refseq_name": "myosin light chain 1, skeletal muscle isoform isoform X1", "refseq_ac": [ { "id": "XP_015144626", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015144626", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "MLC-1; MLC-3; MLC; MYL1", "protein_names_uniprotkb": "Myosin light chain 1, skeletal muscle isoform; Alkali myosin light chain 1; MLC-1; Myosin light chain 1f; Myosin light chain A1; Myosin light chain alkali 1; Skeletal-muscle myosin L-1 light chain", "protein_names_refseq": "myosin light chain 1, skeletal muscle isoform isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 6, "publication_id_list": "3979397;6128725;6709041;7173826;7238855;8316857", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015144626.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90895;Q9PWQ5", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0043292 contractile muscle fiber;GO:0016460 myosin II complex", "go_biological_process": "GO:0043520 regulation of myosin II filament assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P02604-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02605-1", "uniprot_id": [ { "id": "MLE3_CHICK", "url": "https://www.uniprot.org/uniprot/P02605", "type": "external" } ], "mass": 16710.0, "length": 150, "protein_name": "Myosin light chain 3, skeletal muscle isoform", "gene_name": "", "organism": "Chicken", "refseq_name": "myosin light chain 1, skeletal muscle isoform", "refseq_ac": [ { "id": "NP_001038097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038097", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "MLC-1; MLC-3; MLC; MYL1", "protein_names_uniprotkb": "Myosin light chain 3, skeletal muscle isoform; Alkali myosin light chain 3; MLC-3; Myosin light chain 3f; Myosin light chain A2; Myosin light chain alkali 2; Skeletal-muscle myosin L-4 light chain", "protein_names_refseq": "alkali myosin light chain 1; alkali myosin light chain 3; myosin a1; myosin light chain 1, skeletal muscle isoform; myosin light chain 1f; myosin light chain 3f; myosin light chain A1; myosin light chain A2; myosin light chain alkali 1; myosin light chain alkali 2; myosin, light polypeptide 1, alkali; skeletal, fast; skeletal-muscle myosin L-1 light chain; skeletal-muscle myosin L-4 light chain", "tax_id": 9031, "disease": "", "pathway": " (gga:396470)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "22455925;23899007;6128725;6709041;6783403", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01006668.1, HAEK01048377.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992437 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000235.1. On Sep 23, 2021 this sequence version replaced NP_001038097.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Fiber fluorescence data were interpreted using the crystal structure of the head domain of chicken skeletal myosin in the nucleotide-free state., [RefSeq, PubMed]; Metastasis of aggressive amoeboid sarcoma cells is dependent on Rho/ROCK/MLC signaling. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90896", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0043292 contractile muscle fiber;GO:0016460 myosin II complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P02605-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02707-1", "uniprot_id": [ { "id": "LECH_CHICK", "url": "https://www.uniprot.org/uniprot/P02707", "type": "external" } ], "mass": 24216.0, "length": 207, "protein_name": "Hepatic lectin", "gene_name": "", "organism": "Chicken", "refseq_name": "hepatic lectin", "refseq_ac": [ { "id": "NP_990815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990815", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "LOC396477", "protein_names_uniprotkb": "Hepatic lectin", "protein_names_refseq": "hepatic lectin", "tax_id": 9031, "disease": "", "pathway": " (gga:396477)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2050668;3281941;7240175", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU125096.1, J03188.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000389.1. On Aug 30, 2004 this sequence version replaced XP_423768.1., [RefSeq]; Hepatic lectin is a membrane receptor protein that recognizes and binds exposed N-acetylglucosamine moieties of plasma glycoproteins, thus mediating their clearance (from the circulation) and endocytosis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P02707-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02713-1", "uniprot_id": [ { "id": "ACHG_CHICK", "url": "https://www.uniprot.org/uniprot/P02713", "type": "external" } ], "mass": 58926.0, "length": 514, "protein_name": "Acetylcholine receptor subunit gamma", "gene_name": "CHRNG", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CHRNG", "gene_names_refseq": "", "protein_names_uniprotkb": "Acetylcholine receptor subunit gamma", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1330309;6096871", "class_list": "", "function": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0095500 acetylcholine receptor signaling pathway;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport;GO:0051899 membrane depolarization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P02713-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P02717-1", "uniprot_id": [ { "id": "ACHD_CHICK", "url": "https://www.uniprot.org/uniprot/P02717", "type": "external" } ], "mass": 59011.0, "length": 513, "protein_name": "Acetylcholine receptor subunit delta", "gene_name": "CHRND", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CHRND", "gene_names_refseq": "", "protein_names_uniprotkb": "Acetylcholine receptor subunit delta", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2311580;6096871", "class_list": "", "function": "After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0095500 acetylcholine receptor signaling pathway;GO:0007268 chemical synaptic transmission;GO:0034220 monoatomic ion transmembrane transport;GO:0051899 membrane depolarization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P02717-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P04047-1", "uniprot_id": [ { "id": "KITH_CHICK", "url": "https://www.uniprot.org/uniprot/P04047", "type": "external" } ], "mass": 24872.0, "length": 224, "protein_name": "Thymidine kinase, cytosolic", "gene_name": "TK1", "organism": "Chicken", "refseq_name": "thymidine kinase, cytosolic", "refseq_ac": [ { "id": "NP_990229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990229", "type": "external" } ], "gene_names_uniprotkb": "TK1", "gene_names_refseq": "TK1; TK", "protein_names_uniprotkb": "Thymidine kinase, cytosolic; 2.7.1.21", "protein_names_refseq": "thymidine kinase 1, soluble; thymidine kinase, cytosolic", "tax_id": 9031, "disease": "", "pathway": " (gga:395719)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "6092937;6328447", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01000291.1, HAEK01032351.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000317.1. On Oct 9, 2004 this sequence version replaced XP_420091.1., [RefSeq]; Cell-cycle-regulated enzyme of importance in nucleotide metabolism. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.74", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.74", "type": "external" }, { "id": "2.7.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.21", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0004797 thymidine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0046104 thymidine metabolic process;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P04047-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05083-1", "uniprot_id": [ { "id": "ARLY2_CHICK", "url": "https://www.uniprot.org/uniprot/P05083", "type": "external" } ], "mass": 51044.0, "length": 466, "protein_name": "Argininosuccinate lyase", "gene_name": "ASL2", "organism": "Chicken", "refseq_name": "argininosuccinate lyase", "refseq_ac": [ { "id": "NP_001025885", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025885", "type": "external" } ], "gene_names_uniprotkb": "ASL2", "gene_names_refseq": "ASL2; ASL; CRYD2; delta-2-crystallin", "protein_names_uniprotkb": "Argininosuccinate lyase; 4.3.2.1; ASAL; Arginosuccinase; Delta crystallin II; Delta-2 crystallin", "protein_names_refseq": "ASAL; argininosuccinate lyase 2; argininosuccinate lyase; arginosuccinase; crystallin delta 2; delta crystallin II; delta-2 crystallin; delta-crystallin 2", "tax_id": 9031, "disease": "", "pathway": " (gga:417545); (R-GGA-187630)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "3941090;4018032;6418730;9792920", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01000179.1, HAEL01000060.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000323.1. On Dec 6, 2009 this sequence version replaced XP_415792.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles. This protein may also function as an enzymatically active argininosuccinate lyase., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.2.1", "type": "external" } ], "go_molecular_function": "GO:0004056 argininosuccinate lyase activity;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006525 arginine metabolic process;GO:0042450 L-arginine biosynthetic process via ornithine", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P05083-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P05099-1", "uniprot_id": [ { "id": "MATN1_CHICK", "url": "https://www.uniprot.org/uniprot/P05099", "type": "external" } ], "mass": 54034.0, "length": 493, "protein_name": "Matrilin-1", "gene_name": "MATN1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MATN1; CMP", "gene_names_refseq": "", "protein_names_uniprotkb": "Matrilin-1; Cartilage matrix protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "1600245;2542265;3025875;9260286", "class_list": "", "function": "A major component of the extracellular matrix of non-articular cartilage (PubMed:1600245). Binds to type 2 collagens and forms long concatenated protein networks as part of the extracellular matrix (PubMed:1600245). Required for the network-like organization and bundling of collagen fibrils surrounding chondrocytes in the zones of maturation and hypertrophy (By similarity). Required for mechanotransduction and adaption to mechanical loading in cartilage chondrocytes, resulting in an increase in expression of the extracellular matrix components ACAN and COL2A1 (By similarity). Acts as a moderator of angiogenesis in response to injury (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P05099-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07322-1", "uniprot_id": [ { "id": "ENOB_CHICK", "url": "https://www.uniprot.org/uniprot/P07322", "type": "external" } ], "mass": 47196.0, "length": 434, "protein_name": "Beta-enolase", "gene_name": "ENO3", "organism": "Chicken", "refseq_name": "beta-enolase", "refseq_ac": [ { "id": "NP_990450", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990450", "type": "external" } ], "gene_names_uniprotkb": "ENO3", "gene_names_refseq": "ENO3", "protein_names_uniprotkb": "Beta-enolase; 2-phospho-D-glycerate hydro-lyase; 4.2.1.11; Phosphopyruvate hydratase", "protein_names_refseq": "2-phospho-D-glycerate hydro-lyase; beta-enolase; phosphopyruvate hydratase", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-352875); (R-GGA-352882)", "pathway_count": 2, "publication_count": 18, "publication_id_list": "1593633;16287166;2110163;2898218;2985560;3094011;3539098;3885220;4463937;499525;6303388;6345546;6574503;7629021;7768978;7916593;8182283;9434147", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D37901.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D37901.1., [RefSeq]; Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.11", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004634 phosphopyruvate hydratase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0000015 phosphopyruvate hydratase complex", "go_biological_process": "GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 1.9, "record_id": "P07322-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P07916-1", "uniprot_id": [ { "id": "ELN_CHICK", "url": "https://www.uniprot.org/uniprot/P07916", "type": "external" } ], "mass": 63696.0, "length": 750, "protein_name": "Elastin", "gene_name": "ELN", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ELN", "gene_names_refseq": "", "protein_names_uniprotkb": "Elastin; Tropoelastin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "2841924;3502711;3593675;6696746", "class_list": "", "function": "Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P07916-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08070-1", "uniprot_id": [ { "id": "TBA2_CHICK", "url": "https://www.uniprot.org/uniprot/P08070", "type": "external" } ], "mass": 49798.0, "length": 446, "protein_name": "Tubulin alpha-2 chain", "gene_name": "", "organism": "Chicken", "refseq_name": "tubulin alpha-2 chain", "refseq_ac": [ { "id": "NP_990775", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990775", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "TUBA8B; TUBA8; TUBAT", "protein_names_uniprotkb": "Tubulin alpha-2 chain; 3.6.5.-; Testis-specific", "protein_names_refseq": "testis-specific alpha-tubulin; tubulin alpha-2 chain; tubulin, alpha 8", "tax_id": 9031, "disease": "", "pathway": " (gga:396426)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18612635;3561402", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CO635770.1, SRR12888549.117899.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Oct 29, 2021 this sequence version replaced NP_990775.1., [RefSeq]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P08070-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08267-1", "uniprot_id": [ { "id": "FRIH_CHICK", "url": "https://www.uniprot.org/uniprot/P08267", "type": "external" } ], "mass": 21092.0, "length": 180, "protein_name": "Ferritin heavy chain", "gene_name": "FTH", "organism": "Chicken", "refseq_name": "ferritin heavy chain", "refseq_ac": [ { "id": "NP_990417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990417", "type": "external" } ], "gene_names_uniprotkb": "FTH", "gene_names_refseq": "FTH1; FTH", "protein_names_uniprotkb": "Ferritin heavy chain; 1.16.3.1; Ferritin H subunit", "protein_names_refseq": "ferritin H chain; ferritin H subunit; ferritin heavy chain; ferritin, heavy polypeptide 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395970); (R-GGA-432722); (R-GGA-6798695); (R-GGA-917937)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "16879355;18729209;21305469;3600643", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y14698.1, HAEK01200281.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992428 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000214.1., [RefSeq]; Data show that during development ferritoid appears before ferritin. At this time, ferritoid is cytoplasmic, suggesting that its nuclear transport function requires an interaction with ferritin., [RefSeq, PubMed]; Data show that three isolated genes: Defender Against Cell Death (Dad1), Polyubiquitin II (UbII) and Ferritin Heavy chain (fth1), are implicated in Programmed Cell Death (PCD)., [RefSeq, PubMed]; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Delivery to lysosomes is mediated by the cargo receptor NCOA4 for autophagic degradation and release of iron (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": 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The reference sequence was derived from JAENSK010000012.1. On Apr 5, 2013 this sequence version replaced XP_416189.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P08286-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08287-1", "uniprot_id": [ { "id": "H11L_CHICK", "url": "https://www.uniprot.org/uniprot/P08287", "type": "external" } ], "mass": 22528.0, "length": 225, "protein_name": "Histone H1.11L", "gene_name": "", "organism": "Chicken", "refseq_name": "histone H1.11L", "refseq_ac": [ { "id": "NP_001035733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035733", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "H1-1L; HIST1H111L; HIST1H1C", "protein_names_uniprotkb": "Histone H1.11L", "protein_names_refseq": "histone 1, H1c; histone H1.11L; histone cluster 1, H1.11L (similar to human histone cluster 1, class H1 genes)", "tax_id": 9031, "disease": "", "pathway": " (gga:427892)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "3597432;8218199", "class_list": "", "function": "Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures., [UniProtKB]; PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M17019.1. On May 16, 2006 this sequence version replaced XP_425466.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P08287-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P08940-1", "uniprot_id": [ { "id": "MIM1_CHICK", "url": "https://www.uniprot.org/uniprot/P08940", "type": "external" } ], "mass": 35637.0, "length": 326, "protein_name": "Myeloid protein 1", "gene_name": "MIM1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MIM1; MIM-1", "gene_names_refseq": "", "protein_names_uniprotkb": "Myeloid protein 1; p33", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1397316;2688896", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0044194 cytolytic granule", "go_biological_process": "GO:0030851 granulocyte differentiation;GO:0046677 response to antibiotic", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P08940-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09203-1", "uniprot_id": [ { "id": "TBB1_CHICK", "url": "https://www.uniprot.org/uniprot/P09203", "type": "external" } ], "mass": 49909.0, "length": 445, "protein_name": "Tubulin beta-1 chain", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubulin beta-1 chain; Beta-tubulin class-I", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3837190", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02555", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0001764 neuron migration;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P09203-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09206-1", "uniprot_id": [ { "id": "TBB3_CHICK", "url": "https://www.uniprot.org/uniprot/P09206", "type": "external" } ], "mass": 49861.0, "length": 445, "protein_name": "Tubulin beta-3 chain", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubulin beta-3 chain; Beta-tubulin class-IV", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "28483977;3759966", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a role in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:1990791 dorsal root ganglion development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P09206-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09207-1", "uniprot_id": [ { "id": "TBB6_CHICK", "url": "https://www.uniprot.org/uniprot/P09207", "type": "external" } ], "mass": 50154.0, "length": 446, "protein_name": "Tubulin beta-6 chain", "gene_name": "", "organism": "Chicken", "refseq_name": "tubulin beta-6 chain", "refseq_ac": [ { "id": "NP_990776", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990776", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "TUBB1", "protein_names_uniprotkb": "Tubulin beta-6 chain; Beta-tubulin class-VI", "protein_names_refseq": "beta-tubulin class-VI; tubulin beta-6 chain; tubulin, beta 3", "tax_id": 9031, "disease": "", "pathway": " (gga:396427)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18083574;25860507;2888766", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: J02828.1, SRR13267658.24170.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992648 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000328.1., [RefSeq]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P09207-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09244-1", "uniprot_id": [ { "id": "TBB7_CHICK", "url": "https://www.uniprot.org/uniprot/P09244", "type": "external" } ], "mass": 49671.0, "length": 444, "protein_name": "Tubulin beta-7 chain", "gene_name": "", "organism": "Chicken", "refseq_name": "tubulin beta-7 chain", "refseq_ac": [ { "id": "NP_990646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990646", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "TUBB", "protein_names_uniprotkb": "Tubulin beta-7 chain; Tubulin beta 4'", "protein_names_refseq": "beta 5-tubulin; c(beta)7 tubulin; tubulin beta 4'; tubulin beta-7 chain; tubulin, beta 2A; tubulin, beta polypeptide", "tax_id": 9031, "disease": "", "pathway": " (gga:396254)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "3351937", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]; VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSL010000175.1. On or before May 8, 2024 this sequence version replaced XP_046793428.1, XP_001236061.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P09244-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09479-1", "uniprot_id": [ { "id": "ACHA_CHICK", "url": "https://www.uniprot.org/uniprot/P09479", "type": "external" } ], "mass": 52183.0, "length": 456, "protein_name": "Acetylcholine receptor subunit alpha", "gene_name": "CHRNA1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CHRNA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Acetylcholine receptor subunit alpha", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395608)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1379917;3267226;3821734;3860855;6327170", "class_list": "", "function": "Upon acetylcholine binding, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P09479-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09480-1", "uniprot_id": [ { "id": "ACHA2_CHICK", "url": "https://www.uniprot.org/uniprot/P09480", "type": "external" } ], "mass": 60675.0, "length": 528, "protein_name": "Neuronal acetylcholine receptor subunit alpha-2", "gene_name": "CHRNA2", "organism": "Chicken", "refseq_name": "neuronal acetylcholine receptor subunit alpha-2 precursor", "refseq_ac": [ { "id": "NP_990146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990146", "type": "external" } ], "gene_names_uniprotkb": "CHRNA2", "gene_names_refseq": "CHRNA2; NACHRA2", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-2", "protein_names_refseq": "alpha-2 subunit, nicotinic acetylcholine receptor; cholinergic receptor, nicotinic, alpha 2 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal); neuronal acetylcholine receptor subunit alpha-2 precursor; neuronal acetylcholine receptor subunit alpha-2", "tax_id": 9031, "disease": "", "pathway": " (gga:395607)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "3267226;7678806", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ250360.1, SRR13267654.118095.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992432, SAMEA103992440 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ250360.1., [RefSeq]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA2 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4 and plays a role in nicotine dependence., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0095500 acetylcholine receptor signaling pathway;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P09480-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09531-1", "uniprot_id": [ { "id": "TGFB1_CHICK", "url": "https://www.uniprot.org/uniprot/P09531", "type": "external" } ], "mass": 44437.0, "length": 391, "protein_name": "Transforming growth factor beta-1 proprotein", "gene_name": "TGFB1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TGFB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Transforming growth factor beta-1 proprotein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "1353860;15592404;2464131", "class_list": "", "function": "Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1., [UniProtKB, UniProtKB]; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively., [UniProtKB, UniProtKB]; Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains remain non-covalently linked rendering TGF-beta-1 inactive during storage in extracellular matrix. At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS that control activation of TGF-beta-1 and maintain it in a latent state during storage in extracellular milieus. TGF-beta-1 is released from LAP by integrins (ITGAV:ITGB6 or ITGAV:ITGB8): integrin-binding to LAP stabilizes an alternative conformation of the LAP bowtie tail and results in distortion of the LAP chain and subsequent release of the active TGF-beta-1. Once activated following release of LAP, TGF-beta-1 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). While expressed by many cells types, TGF-beta-1 only has a very localized range of action within cell environment thanks to fine regulation of its activation by Latency-associated peptide chain (LAP) and 'milieu molecules'. Plays an important role in bone remodeling: acts as a potent stimulator of osteoblastic bone formation. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner (By similarity). Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PM67", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005160 transforming growth factor beta receptor binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007507 heart development;GO:0030154 cell differentiation;GO:0042127 regulation of cell population proliferation;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0051781 positive regulation of cell division", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P09531-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09642-1", "uniprot_id": [ { "id": "TBA3_CHICK", "url": "https://www.uniprot.org/uniprot/P09642", "type": "external" } ], "mass": 36088.0, "length": 322, "protein_name": "Tubulin alpha-3 chain", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubulin alpha-3 chain; 3.6.5.-", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3267229", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. 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Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P09652-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09653-1", "uniprot_id": [ { "id": "TBB5_CHICK", "url": "https://www.uniprot.org/uniprot/P09653", "type": "external" } ], "mass": 49971.0, "length": 446, "protein_name": "Tubulin beta-5 chain", "gene_name": "", "organism": "Chicken", "refseq_name": "tubulin beta-5 chain", "refseq_ac": [ { "id": "NP_001026183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026183", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "TUBB6", "protein_names_uniprotkb": "Tubulin beta-5 chain; Beta-tubulin class-V", "protein_names_refseq": "beta-5 tubulin; beta-tubulin class-V; tubulin beta-5 chain", "tax_id": 9031, "disease": "", "pathway": " (gga:421037); (R-GGA-2467813); (R-GGA-2500257); (R-GGA-3371497); (R-GGA-5620924); (R-GGA-6807878); (R-GGA-6811434); (R-GGA-6811436); (R-GGA-9646399); (R-GGA-9648025); (R-GGA-983189)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "3025656", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01000228.1, HAEK01051231.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992432, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000042.1. On Sep 23, 2021 this sequence version replaced NP_001026183.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P09653-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09654-1", "uniprot_id": [ { "id": "VIME_CHICK", "url": "https://www.uniprot.org/uniprot/P09654", "type": "external" } ], "mass": 53142.0, "length": 460, "protein_name": "Vimentin", "gene_name": "VIM", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "VIM", "gene_names_refseq": "", "protein_names_uniprotkb": "Vimentin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "19132533;3036797;6573660", "class_list": "", "function": "Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91023", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0005882 intermediate filament;GO:0016363 nuclear matrix", "go_biological_process": "GO:0045109 intermediate filament organization;GO:0010634 positive regulation of epithelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P09654-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P09987-1", "uniprot_id": [ { "id": "H1_CHICK", "url": "https://www.uniprot.org/uniprot/P09987", "type": "external" } ], "mass": 21881.0, "length": 218, "protein_name": "Histone H1", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "6190814", "class_list": "", "function": "Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P09987-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0C597-1", "uniprot_id": [ { "id": "DUS29_CHICK", "url": "https://www.uniprot.org/uniprot/P0C597", "type": "external" } ], "mass": 24322.0, "length": 214, "protein_name": "Dual specificity phosphatase 29", "gene_name": "DUSP29", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DUSP29; DUPD1", "gene_names_refseq": "", "protein_names_uniprotkb": "Dual specificity phosphatase 29; 3.1.3.16; 3.1.3.48; Dual specificity phosphatase DUPD1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "16093725", "class_list": "", "function": "Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues within the same substrate, with a preference for phosphotyrosine as a substrate (By similarity). Involved in the modulation of AMPK and MAPK1/2 signaling pathways (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" } ], "go_molecular_function": "GO:0004722 protein serine/threonine phosphatase activity;GO:0008138 protein tyrosine/serine/threonine phosphatase activity;GO:0033549 MAP kinase phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006470 protein dephosphorylation;GO:0043409 negative regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P0C597-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CB05-1", "uniprot_id": [ { "id": "CEP63_CHICK", "url": "https://www.uniprot.org/uniprot/P0CB05", "type": "external" } ], "mass": 82000.0, "length": 711, "protein_name": "Centrosomal protein of 63 kDa", "gene_name": "CEP63", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CEP63", "gene_names_refseq": "", "protein_names_uniprotkb": "Centrosomal protein of 63 kDa; Cep63", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15592404;19182792", "class_list": "", "function": "Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication (PubMed:19182792). Plays a role in DNA damage response (PubMed:19182792). Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:19182792)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005814 centriole", "go_biological_process": "GO:0051301 cell division;GO:0042770 signal transduction in response to DNA damage;GO:0000077 DNA damage checkpoint signaling;GO:0051225 spindle assembly;GO:0007099 centriole replication", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P0CB05-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0CF65-1", "uniprot_id": [ { "id": "CRBN_CHICK", "url": "https://www.uniprot.org/uniprot/P0CF65", "type": "external" } ], "mass": 51118.0, "length": 445, "protein_name": "Protein cereblon", "gene_name": "CRBN", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CRBN", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein cereblon", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "15592404;20223979;25043012", "class_list": "", "function": "Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (PubMed:20223979). Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (By similarity). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0060173 limb development;GO:0030177 positive regulation of Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P0CF65-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P0DJJ2-1", "uniprot_id": [ { "id": "ASTL_CHICK", "url": "https://www.uniprot.org/uniprot/P0DJJ2", "type": "external" } ], "mass": 46388.0, "length": 409, "protein_name": "Astacin-like metalloendopeptidase", "gene_name": "ASTL", "organism": "Chicken", "refseq_name": "astacin-like metalloendopeptidase precursor", "refseq_ac": [ { "id": "NP_001292019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292019", "type": "external" } ], "gene_names_uniprotkb": "ASTL", "gene_names_refseq": "ASTL; HE2A; LOC423176", "protein_names_uniprotkb": "Astacin-like metalloendopeptidase; 3.4.-.-", "protein_names_refseq": "astacin like metalloendopeptidase; astacin-like metallo-endopeptidase (M12 family); astacin-like metalloendopeptidase precursor; hatching enzyme 2A", "tax_id": 9031, "disease": "", "pathway": " (gga:423176)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12445392;15592404;16903475;22275110", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01008636.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992428, SAMEA103992559 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1. On Dec 3, 2021 this sequence version replaced NP_001292019.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; ASTL is dynamically expressed in the embryonic epithelium and in embryonic stem cells, suggesting an important function for the control of epithelial cell behavior during early development., [RefSeq, PubMed]; Probable oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. May act as a protease (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0008233 peptidase activity;GO:0070001 aspartic-type peptidase activity;GO:0070002 glutamic-type peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0060473 cortical granule", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0009566 fertilization;GO:0010954 positive regulation of protein processing;GO:0060468 prevention of polyspermy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P0DJJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11009-1", "uniprot_id": [ { "id": "KCRS_CHICK", "url": "https://www.uniprot.org/uniprot/P11009", "type": "external" } ], "mass": 47084.0, "length": 419, "protein_name": "Creatine kinase S-type, mitochondrial", "gene_name": "CKMT2", "organism": "Chicken", "refseq_name": "creatine kinase S-type, mitochondrial", "refseq_ac": [ { "id": "NP_001161216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161216", "type": "external" } ], "gene_names_uniprotkb": "CKMT2", "gene_names_refseq": "CKMT2; MIBCK; SMTCK", "protein_names_uniprotkb": "Creatine kinase S-type, mitochondrial; 2.7.3.2; Basic-type mitochondrial creatine kinase; Mib-CK; S-MtCK; Sarcomeric mitochondrial creatine kinase", "protein_names_refseq": "S-MtCK; basic-type mitochondrial creatine kinase; creatine kinase S-type, mitochondrial; creatine kinase, mitochondrial 2 (sarcomeric); mib-CK; sarcomeric mitochondrial creatine kinase", "tax_id": 9031, "disease": "", "pathway": " (gga:396508)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "2831887;8305443;8662608;8692275", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01041016.1, SRR12888541.280307.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000095.1. On Nov 18, 2009 this sequence version replaced XP_424899.1., [RefSeq]; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" } ], "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0046314 phosphocreatine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P11009-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P11533-1", "uniprot_id": [ { "id": "DMD_CHICK", "url": "https://www.uniprot.org/uniprot/P11533", "type": "external" } ], "mass": 422881.0, "length": 3660, "protein_name": "Dystrophin", "gene_name": "DMD", "organism": "Chicken", "refseq_name": "dystrophin", "refseq_ac": [ { "id": "NP_990630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990630", "type": "external" } ], "gene_names_uniprotkb": "DMD", "gene_names_refseq": "DMD", "protein_names_uniprotkb": "Dystrophin", "protein_names_refseq": "dystrophin; putative short dystrophin", "tax_id": 9031, "disease": "", "pathway": " (gga:396236)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "24014171;3062582;3072195", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X13369.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000021.1. On Sep 23, 2021 this sequence version replaced NP_990630.2. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; May play a role in anchoring the cytoskeleton to the plasma membrane., [UniProtKB]; Ordered disorder of the astrocytic dystrophin-associated protein complex in the norm and pathology. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0016010 dystrophin-associated glycoprotein complex;GO:0005856 cytoskeleton;GO:0045211 postsynaptic membrane;GO:0042383 sarcolemma;GO:0030016 myofibril", "go_biological_process": "GO:0048666 neuron development;GO:0007519 skeletal muscle tissue development;GO:0055001 muscle cell development;GO:0090257 regulation of muscle system process;GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P11533-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12106-1", "uniprot_id": [ { "id": "CO9A1_CHICK", "url": "https://www.uniprot.org/uniprot/P12106", "type": "external" } ], "mass": 91474.0, "length": 920, "protein_name": "Collagen alpha-1(IX) chain", "gene_name": "COL9A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COL9A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(IX) chain", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 7, "publication_id_list": "2422170;2584206;2981204;3339014;3858862;3868958;6328487", "class_list": "", "function": "Structural component of hyaline cartilage and vitreous of the eye., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q90779", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005594 collagen type IX trimer", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0009887 animal organ morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P12106-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12394-1", "uniprot_id": [ { "id": "CP17A_CHICK", "url": "https://www.uniprot.org/uniprot/P12394", "type": "external" } ], "mass": 56984.0, "length": 508, "protein_name": "Steroid 17-alpha-hydroxylase/17,20 lyase", "gene_name": "CYP17A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CYP17A1; CYP17", "gene_names_refseq": "", "protein_names_uniprotkb": "Steroid 17-alpha-hydroxylase/17,20 lyase; 1.14.14.19; 1.14.14.32; 17-alpha-hydroxyprogesterone aldolase; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:425056)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "3047010", "class_list": "", "function": "Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.19", "type": "external" }, { "id": "1.14.14.32", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.32", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016829 lyase activity;GO:0019825 oxygen binding;GO:0004508 steroid 17-alpha-monooxygenase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0042446 hormone biosynthetic process;GO:0046677 response to antibiotic;GO:0006694 steroid biosynthetic process;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P12394-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P12620-1", "uniprot_id": [ { "id": "TNNT3_CHICK", "url": "https://www.uniprot.org/uniprot/P12620", "type": "external" } ], "mass": 31142.0, "length": 263, "protein_name": "Troponin T, fast skeletal muscle isoforms", "gene_name": "TNNT3", "organism": "Chicken", "refseq_name": "troponin T, fast skeletal muscle isoforms isoform X30", "refseq_ac": [ { "id": "XP_015142056", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015142056", "type": "external" } ], "gene_names_uniprotkb": "TNNT3", "gene_names_refseq": "TNNT3", "protein_names_uniprotkb": "Troponin T, fast skeletal muscle isoforms", "protein_names_refseq": "troponin T, fast skeletal muscle isoforms isoform X30", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15784741;3198600", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P12618;P12619;P12621", "ec_number_list": [], "go_molecular_function": "GO:0030172 troponin C binding;GO:0005523 tropomyosin binding;GO:0031013 troponin I binding", "go_cellular_component": "GO:0005861 troponin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0045214 sarcomere organization;GO:0006937 regulation of muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P12620-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P13648-1", "uniprot_id": [ { "id": "LMNA_CHICK", "url": "https://www.uniprot.org/uniprot/P13648", "type": "external" } ], "mass": 73164.0, "length": 657, "protein_name": "Lamin-A", "gene_name": "LMNA", "organism": "Chicken", "refseq_name": "lamin-A", "refseq_ac": [ { "id": "NP_990618", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990618", "type": "external" } ], "gene_names_uniprotkb": "LMNA", "gene_names_refseq": "LMNA; lamin-A", "protein_names_uniprotkb": "Lamin-A", "protein_names_refseq": "lamin A; lamin-A", "tax_id": 9031, "disease": "", "pathway": " (gga:396224)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2795656", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X16879.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X16879.1., [RefSeq]; Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (By similarity). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (By similarity). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0160123 structural constituent of nuclear lamina", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005882 intermediate filament;GO:0016363 nuclear matrix;GO:0005652 nuclear lamina", "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0006998 nuclear envelope organization;GO:0031507 heterochromatin formation;GO:0007097 nuclear migration;GO:0051664 nuclear pore localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P13648-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P14154-1", "uniprot_id": [ { "id": "CXA1_CHICK", "url": "https://www.uniprot.org/uniprot/P14154", "type": "external" } ], "mass": 43125.0, "length": 381, "protein_name": "Gap junction alpha-1 protein", "gene_name": "GJA1", "organism": "Chicken", "refseq_name": "gap junction alpha-1 protein", "refseq_ac": [ { "id": "NP_989917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989917", "type": "external" } ], "gene_names_uniprotkb": "GJA1", "gene_names_refseq": "CX43; GJA1; connexin-43", "protein_names_uniprotkb": "Gap junction alpha-1 protein; Connexin-43; Cx43", "protein_names_refseq": "connexin 43; gap junction alpha-1 protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395278)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12487409;15843434;18676366;2166164;26782534;30560870", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01032399.1, M29003.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000063.1. On Sep 23, 2021 this sequence version replaced NP_989917.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Fluid flow shear stress induces the translocation of Cx43 to the membrane surface and unapposed hemichannels formed by Cx43 serve as a novel portal for the release of PGE2 in response to mechanical strain, [RefSeq, PubMed]; Functional disruption experiments in chicken embryos and promoter analysis implicate synergistic Hedgehog and WNT/beta-Catenin signaling in activating Connexin-43 expression, establishing gap junction networks synchronizing the Ca2+ profile among cells, thereby coordinating cell movement patterns during feather bud elongation. Publication Status: Online-Only, [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Plays an essential role in gap junction communication in the ventricles., [UniProtKB, UniProtKB]; That Cx43-hemichannel activity associated with PGE(2) release is adaptively regulated by mechanical loading to provide an effective means of regulating levels of extracellular signaling molecules responsible for initiation of bone (re)modeling., [RefSeq, PubMed]; The present study describes four previously unknown SNPs, four haplotypes from two variants having high linkage disequilibrium, and seven diplotypes of the chicken GJA1 gene, and reports their significant association with growth traits. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90ZE0", "ec_number_list": [], "go_molecular_function": "GO:0055077 gap junction hemi-channel activity;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0014704 intercalated disc;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007507 heart development;GO:0010644 cell communication by electrical coupling;GO:0099111 microtubule-based transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P14154-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15120-1", "uniprot_id": [ { "id": "UROK_CHICK", "url": "https://www.uniprot.org/uniprot/P15120", "type": "external" } ], "mass": 49400.0, "length": 434, "protein_name": "Urokinase-type plasminogen activator", "gene_name": "PLAU", "organism": "Chicken", "refseq_name": "urokinase-type plasminogen activator preproprotein", "refseq_ac": [ { "id": "NP_990774", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990774", "type": "external" } ], "gene_names_uniprotkb": "PLAU", "gene_names_refseq": "PLAU", "protein_names_uniprotkb": "Urokinase-type plasminogen activator; 3.4.21.73; U-plasminogen activator; uPA", "protein_names_refseq": "U-plasminogen activator; uPA; urokinase-type plasminogen activator preproprotein; urokinase-type plasminogen activator", "tax_id": 9031, "disease": "", "pathway": " (gga:396424); (R-GGA-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "2295632;24481918", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: J05187.1, ERR2286007.87608.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000231.1. On Sep 23, 2021 this sequence version replaced NP_990774.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Serine protease that cleaves the inactive precursor plasminogen at a specific Arg-Val peptide bond, converting it into active plasmin. Secreted as an inactive zymogen, it is recruited and activated at the cell surface through interaction with the urokinase plasminogen activator receptor (uPAR). Cell-surface activation enables localized, plasmin-dependent pericellular proteolysis, regulating extracellular matrix degradation in cell migration and tissue remodeling (By similarity). Also contributes to fibrinolysis and blood clot clearance by promoting plasmin generation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; UPA has a key role during CNS development. In association with its receptor, it orchestrates both proteolytic and nonproteolytic events that govern the proper formation of neural networks., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0031639 plasminogen activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P15120-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15340-1", "uniprot_id": [ { "id": "HSP1_CHICK", "url": "https://www.uniprot.org/uniprot/P15340", "type": "external" } ], "mass": 8117.0, "length": 62, "protein_name": "Sperm histone", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Sperm histone; Galline; Protamine", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2745455;2892748;992941", "class_list": "", "function": "Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02320", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0031406 carboxylic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0030261 chromosome condensation;GO:0035092 sperm DNA condensation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P15340-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15575-1", "uniprot_id": [ { "id": "B3AT_CHICK", "url": "https://www.uniprot.org/uniprot/P15575", "type": "external" } ], "mass": 102223.0, "length": 922, "protein_name": "Band 3 anion transport protein", "gene_name": "SLC4A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC4A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Band 3 anion transport protein; Solute carrier family 4 member 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396532)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "3185555", "class_list": "", "function": "Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005452 solute:inorganic anion antiporter activity;GO:0015106 bicarbonate transmembrane transporter activity;GO:0140900 chloride:bicarbonate antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P15575-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15720-1", "uniprot_id": [ { "id": "MBP_CHICK", "url": "https://www.uniprot.org/uniprot/P15720", "type": "external" } ], "mass": 18808.0, "length": 174, "protein_name": "Myelin basic protein", "gene_name": "MBP", "organism": "Chicken", "refseq_name": "myelin basic protein", "refseq_ac": [ { "id": "NP_990611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990611", "type": "external" } ], "gene_names_uniprotkb": "MBP", "gene_names_refseq": "MBP", "protein_names_uniprotkb": "Myelin basic protein; MBP", "protein_names_refseq": "myelin basic protein", "tax_id": 9031, "disease": "", "pathway": " (gga:396217)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18618245;2475444", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X17103.1, CN210845.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X17103.1., [RefSeq]; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0043209 myelin sheath", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P15720-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15743-1", "uniprot_id": [ { "id": "PTHY_CHICK", "url": "https://www.uniprot.org/uniprot/P15743", "type": "external" } ], "mass": 13943.0, "length": 119, "protein_name": "Parathyroid hormone", "gene_name": "PTH", "organism": "Chicken", "refseq_name": "parathyroid hormone preproprotein", "refseq_ac": [ { "id": "NP_990783", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990783", "type": "external" } ], "gene_names_uniprotkb": "PTH", "gene_names_refseq": "PTH", "protein_names_uniprotkb": "Parathyroid hormone; PTH", "protein_names_refseq": "parathyroid hormone preproprotein; thyroid hormone", "tax_id": 9031, "disease": "", "pathway": " (gga:396436); (R-GGA-373080); (R-GGA-418555)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "20852100;2710135;3251402", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M31604.1, M36522.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992533, SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; A single nucleotide polymorphism in parathyroid hormone affected the eggshell percentage and breaking strength, and it may be associated with the variation of serum calcium and PTH level., [RefSeq, PubMed]; Parathyroid hormone elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding;GO:0031857 type 1 parathyroid hormone receptor binding;GO:0031856 parathyroid hormone receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0010629 negative regulation of gene expression;GO:0006874 intracellular calcium ion homeostasis;GO:0030501 positive regulation of bone mineralization;GO:0045725 positive regulation of glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P15743-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15979-1", "uniprot_id": [ { "id": "HA1F_CHICK", "url": "https://www.uniprot.org/uniprot/P15979", "type": "external" } ], "mass": 38246.0, "length": 345, "protein_name": "Class I histocompatibility antigen, F10 alpha chain", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Class I histocompatibility antigen, F10 alpha chain; B-F histocompatibility F10 antigen; B-F-beta-IV; B12", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2370087;3141149", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0042612 MHC class I protein complex", "go_biological_process": "GO:0006955 immune response;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P15979-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P15989-1", "uniprot_id": [ { "id": "CO6A3_CHICK", "url": "https://www.uniprot.org/uniprot/P15989", "type": "external" } ], "mass": 339599.0, "length": 3137, "protein_name": "Collagen alpha-3(VI) chain", "gene_name": "COL6A3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COL6A3", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-3(VI) chain", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "1977751;2322559;2584214", "class_list": "", "function": "Collagen VI acts as a cell-binding protein., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005589 collagen type VI trimer", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P15989-1", "record_type": "protein", "filter_code": "0000000.0000100.001000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16053-1", "uniprot_id": [ { "id": "NFM_CHICK", "url": "https://www.uniprot.org/uniprot/P16053", "type": "external" } ], "mass": 95835.0, "length": 858, "protein_name": "Neurofilament medium polypeptide", "gene_name": "NEFM", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NEFM", "gene_names_refseq": "", "protein_names_uniprotkb": "Neurofilament medium polypeptide; 160 kDa neurofilament protein; NF-M; Neurofilament triplet M protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396206)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2106668;3123320", "class_list": "", "function": "Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with other neuronal intermediate filament proteins to form neuronal filamentous networks (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0030424 axon;GO:0005882 intermediate filament;GO:0099160 postsynaptic intermediate filament cytoskeleton", "go_biological_process": "GO:0033693 neurofilament bundle assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P16053-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16419-1", "uniprot_id": [ { "id": "MYPC2_CHICK", "url": "https://www.uniprot.org/uniprot/P16419", "type": "external" } ], "mass": 126943.0, "length": 1132, "protein_name": "Myosin-binding protein C, fast-type", "gene_name": "MYBPC2", "organism": "Chicken", "refseq_name": "myosin-binding protein C, fast-type", "refseq_ac": [ { "id": "NP_001038124", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038124", "type": "external" } ], "gene_names_uniprotkb": "MYBPC2", "gene_names_refseq": "MYBPC2", "protein_names_uniprotkb": "Myosin-binding protein C, fast-type; C-protein, skeletal muscle fast isoform; Fast MyBP-C", "protein_names_refseq": "fast MyBP-C; myosin binding protein C2; myosin-binding protein C, fast-type", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "20064001;2315308;8227129", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U00922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from U00922.1. On Aug 29, 2006 this sequence version replaced XP_423215.1., [RefSeq]; The developmental expression of the cardiac and skeletal muscle isoforms of myosin-binding protein C throughout development in chick embryos are reported., [RefSeq, PubMed]; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q90606", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0032982 myosin filament;GO:0031430 M band;GO:0031672 A band;GO:0014705 C zone", "go_biological_process": "GO:0007155 cell adhesion;GO:0045214 sarcomere organization;GO:0030241 skeletal muscle myosin thick filament assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P16419-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P16527-1", "uniprot_id": [ { "id": "MARCS_CHICK", "url": "https://www.uniprot.org/uniprot/P16527", "type": "external" } ], "mass": 27728.0, "length": 281, "protein_name": "Myristoylated alanine-rich C-kinase substrate", "gene_name": "MARCKS", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MARCKS", "gene_names_refseq": "", "protein_names_uniprotkb": "Myristoylated alanine-rich C-kinase substrate; MARCKS", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396473)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2608063", "class_list": "", "function": "MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0032432 actin filament bundle", "go_biological_process": "GO:0007015 actin filament organization;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P16527-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17200-1", "uniprot_id": [ { "id": "ACM4_CHICK", "url": "https://www.uniprot.org/uniprot/P17200", "type": "external" } ], "mass": 54937.0, "length": 490, "protein_name": "Muscarinic acetylcholine receptor M4", "gene_name": "CHRM4", "organism": "Chicken", "refseq_name": "muscarinic acetylcholine receptor M4 isoform 2", "refseq_ac": [ { "id": "NP_001026362", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026362", "type": "external" } ], "gene_names_uniprotkb": "CHRM4", "gene_names_refseq": "CHRM4", "protein_names_uniprotkb": "Muscarinic acetylcholine receptor M4", "protein_names_refseq": "muscarinic acetylcholine receptor M4 isoform 2; muscarinic acetylcholine receptor M4", "tax_id": 9031, "disease": "", "pathway": " (gga:423195)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2154460", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.101945.1, SRR13267649.70133.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1. On Dec 9, 2021 this sequence version replaced NP_001026362.1., [RefSeq]; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. May couple to multiple functional responses in cell lines., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0016907 G protein-coupled acetylcholine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007194 negative regulation of adenylate cyclase activity;GO:0040012 regulation of locomotion;GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P17200-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P17923-1", "uniprot_id": [ { "id": "NFIA_CHICK", "url": "https://www.uniprot.org/uniprot/P17923", "type": "external" } ], "mass": 57474.0, "length": 522, "protein_name": "Nuclear factor 1 A-type", "gene_name": "NFIA", "organism": "Chicken", "refseq_name": "nuclear factor 1 A-type isoform X13", "refseq_ac": [ { "id": "XP_046778314", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046778314", "type": "external" } ], "gene_names_uniprotkb": "NFIA; NFI-A", "gene_names_refseq": "CNFI-A; NFIA; cNFI-A3", "protein_names_uniprotkb": "Nuclear factor 1 A-type; CCAAT-box-binding transcription factor; CTF; NF-I/A; NF1-A; NFI-A; Nuclear factor 1/A; Nuclear factor I/A; TGGCA-binding protein", "protein_names_refseq": "nuclear factor 1 A-type isoform X13", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2339052", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052580.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006260 DNA replication;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P17923-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18080-1", "uniprot_id": [ { "id": "HEM0_CHICK", "url": "https://www.uniprot.org/uniprot/P18080", "type": "external" } ], "mass": 54778.0, "length": 513, "protein_name": "5-aminolevulinate synthase, erythroid-specific, mitochondrial", "gene_name": "ALAS2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ALAS2; ALASE", "gene_names_refseq": "", "protein_names_uniprotkb": "5-aminolevulinate synthase, erythroid-specific, mitochondrial; 2.3.1.37; 5-aminolevulinic acid synthase 2; ALAS-E; Delta-ALA synthase 2; Delta-aminolevulinate synthase 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-421984)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16121195;2915978;9808757", "class_list": "", "function": "Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products (By similarity). Contributes significantly to heme formation during erythropoiesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0003870 5-aminolevulinate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process;GO:0042541 hemoglobin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P18080-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18302-1", "uniprot_id": [ { "id": "DREB_CHICK", "url": "https://www.uniprot.org/uniprot/P18302", "type": "external" } ], "mass": 71535.0, "length": 652, "protein_name": "Drebrin", "gene_name": "DBN1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DBN1", "gene_names_refseq": "", "protein_names_uniprotkb": "Drebrin; Developmentally-regulated brain protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396496)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "3208110;8361332", "class_list": "", "function": "Actin cytoskeleton-organizing protein that plays a role in the formation of cell projections (By similarity). Plays a role in dendritic spine morphogenesis and organization, including the localization of the dopamine receptor DRD1 to the dendritic spines (By similarity). Involved in synaptic plasticity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q91358;Q91359", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding", "go_cellular_component": "GO:0014069 postsynaptic density;GO:0030027 lamellipodium;GO:0030425 dendrite;GO:0030426 growth cone;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0048812 neuron projection morphogenesis;GO:0098974 postsynaptic actin cytoskeleton organization;GO:0045773 positive regulation of axon extension;GO:0061003 positive regulation of dendritic spine morphogenesis;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P18302-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18652-1", "uniprot_id": [ { "id": "KS6AA_CHICK", "url": "https://www.uniprot.org/uniprot/P18652", "type": "external" } ], "mass": 84440.0, "length": 752, "protein_name": "Ribosomal protein S6 kinase 2 alpha", "gene_name": "RPS6KA", "organism": "Chicken", "refseq_name": "ribosomal protein S6 kinase 2 alpha", "refseq_ac": [ { "id": "NP_001103241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103241", "type": "external" } ], "gene_names_uniprotkb": "RPS6KA; RSK", "gene_names_refseq": "RPS6KA1L; RPS6KA1; RPS6KA; RSK", "protein_names_uniprotkb": "Ribosomal protein S6 kinase 2 alpha; 2.7.11.1; MAP kinase-activated protein kinase 1; MAPK-activated protein kinase 1; MAPKAP kinase 1; MAPKAPK-1; Ribosomal protein S6 kinase II alpha; S6KII-alpha; p90-RSK", "protein_names_refseq": "MAP kinase-activated protein kinase 1; MAPK-activated protein kinase 1; MAPKAP kinase 1; MAPKAPK-1; S6KII-alpha; p90-RSK; ribosomal protein S6 kinase 2 alpha; ribosomal protein S6 kinase II alpha; ribosomal protein S6 kinase, 90kDa, polypeptide 1", "tax_id": 9031, "disease": "", "pathway": " (gga:386579)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2779569", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267652.8859.1, SRR13267654.60303.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000339.1. Sequence Note: The sequence M28488.1 is from a chimeric clone. Only the ribosomal protein S6 kinase sequence region was propagated into this RefSeq record., [RefSeq]; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004711 ribosomal protein S6 kinase activity;GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0038202 TORC1 signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18652-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18860-1", "uniprot_id": [ { "id": "CXA5_CHICK", "url": "https://www.uniprot.org/uniprot/P18860", "type": "external" } ], "mass": 41745.0, "length": 369, "protein_name": "Gap junction alpha-5 protein", "gene_name": "GJA5", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GJA5", "gene_names_refseq": "", "protein_names_uniprotkb": "Gap junction alpha-5 protein; Connexin-42; Cx42", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2167316", "class_list": "", "function": "One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0086076 gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007507 heart development;GO:0086044 atrial cardiac muscle cell to AV node cell communication by electrical coupling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18860-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18870-1", "uniprot_id": [ { "id": "JUN_CHICK", "url": "https://www.uniprot.org/uniprot/P18870", "type": "external" } ], "mass": 34358.0, "length": 314, "protein_name": "Transcription factor Jun", "gene_name": "JUN", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "JUN", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor Jun; Proto-oncogene c-Jun; Transcription factor AP-1 subunit Jun", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:424673); (R-GGA-437986)", "pathway_count": 2, "publication_count": 10, "publication_id_list": "12193592;13130464;15837794;16186825;17875933;18793328;2577867;7769661;8533096;9195981", "class_list": "", "function": "Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048545 response to steroid hormone;GO:0043923 host-mediated activation of viral transcription", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P18870-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18943-1", "uniprot_id": [ { "id": "COX1_CHICK", "url": "https://www.uniprot.org/uniprot/P18943", "type": "external" } ], "mass": 57051.0, "length": 515, "protein_name": "Cytochrome c oxidase subunit 1", "gene_name": "MT-CO1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MT-CO1; COI; COXI; MTCO1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 1; 7.1.1.9; Cytochrome c oxidase polypeptide I", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2329578", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0006119 oxidative phosphorylation;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18943-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P18944-1", "uniprot_id": [ { "id": "COX2_CHICK", "url": "https://www.uniprot.org/uniprot/P18944", "type": "external" } ], "mass": 25569.0, "length": 227, "protein_name": "Cytochrome c oxidase subunit 2", "gene_name": "MT-CO2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MT-CO2; COII; COXII; MTCO2", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome c oxidase subunit 2; 7.1.1.9; Cytochrome c oxidase polypeptide II", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5419276); (R-GGA-5628897); (R-GGA-611105); (R-GGA-9707564); (R-GGA-9864848)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "2329578", "class_list": "", "function": "Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005507 copper ion binding;GO:0004129 cytochrome-c oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045277 respiratory chain complex IV", "go_biological_process": "GO:0042773 ATP synthesis coupled electron transport;GO:0006979 response to oxidative stress;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P18944-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19019-1", "uniprot_id": [ { "id": "GBRB3_CHICK", "url": "https://www.uniprot.org/uniprot/P19019", "type": "external" } ], "mass": 54433.0, "length": 476, "protein_name": "Gamma-aminobutyric acid receptor subunit beta-3", "gene_name": "GABRB3", "organism": "Chicken", "refseq_name": "gamma-aminobutyric acid receptor subunit beta-3 precursor", "refseq_ac": [ { "id": "NP_990677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990677", "type": "external" } ], "gene_names_uniprotkb": "GABRB3", "gene_names_refseq": "GABRB3", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit beta-3; GABA(A) receptor subunit beta-3; GABAAR subunit beta-3", "protein_names_refseq": "GABA(A) receptor subunit beta-3; GABA-A receptor beta-3 subunit; GABAAR subunit beta-3; gamma-aminobutyric acid (GABA) A receptor, beta 3; gamma-aminobutyric acid receptor subunit beta-3 precursor; gamma-aminobutyric acid receptor subunit beta-3", "tax_id": 9031, "disease": "", "pathway": " (gga:396290)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2170940", "class_list": "", "function": "Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. GABAARs containing beta-3 subunits exhibit synaptogenic activity (By similarity). Extrasynaptic beta-3 receptors contribute to the tonic GABAergic inhibition (By similarity). Beta-containing receptors can also function as histamine receptor where histamine binds at the interface of two neighboring beta subunits (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex;GO:0099634 postsynaptic specialization membrane", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P19019-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19098-1", "uniprot_id": [ { "id": "CP19A_CHICK", "url": "https://www.uniprot.org/uniprot/P19098", "type": "external" } ], "mass": 58146.0, "length": 507, "protein_name": "Aromatase", "gene_name": "CYP19A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CYP19A1; AROM; CYP19", "gene_names_refseq": "", "protein_names_uniprotkb": "Aromatase; 1.14.14.14; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "3182796", "class_list": "", "function": "Catalyzes the formation of aromatic C18 estrogens from C19 androgens., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.14", "type": "external" } ], "go_molecular_function": "GO:0070330 aromatase activity;GO:0005506 iron ion binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0032355 response to estradiol;GO:0008585 female gonad development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P19098-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P19966-1", "uniprot_id": [ { "id": "TAGL_CHICK", "url": "https://www.uniprot.org/uniprot/P19966", "type": "external" } ], "mass": 22315.0, "length": 200, "protein_name": "Transgelin", "gene_name": "TAGLN", "organism": "Chicken", "refseq_name": "transgelin", "refseq_ac": [ { "id": "NP_990825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990825", "type": "external" } ], "gene_names_uniprotkb": "TAGLN; SM22", "gene_names_refseq": "SM22; TAGLN", "protein_names_uniprotkb": "Transgelin; SM22-alpha; Smooth muscle protein 22-alpha", "protein_names_refseq": "SM22-alpha; smooth muscle protein 22-alpha; transgelin", "tax_id": 9031, "disease": "", "pathway": " (gga:396490)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1872880;3571244", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M83105.1, HAEL01002734.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000341.1., [RefSeq]; Actin cross-linking/gelling protein., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P19966-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20678-1", "uniprot_id": [ { "id": "CP2H2_CHICK", "url": "https://www.uniprot.org/uniprot/P20678", "type": "external" } ], "mass": 56485.0, "length": 491, "protein_name": "Cytochrome P450 2H2", "gene_name": "CYP2H2", "organism": "Chicken", "refseq_name": "cytochrome P450 2H2", "refseq_ac": [ { "id": "NP_001001757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001757", "type": "external" } ], "gene_names_uniprotkb": "CYP2H2", "gene_names_refseq": "CYP2C18; CYP2C23b; CYP2C8; CYP2H2; CYPIIH2", "protein_names_uniprotkb": "Cytochrome P450 2H2; 1.14.14.1; CYPIIH2; Cytochrome P450 PCHP7", "protein_names_refseq": "cytochrome P450 2H2; cytochrome P450 PCHP7; cytochrome P450, family 2, subfamily C, polypeptide 18; cytochrome P450, family 2, subfamily C, polypeptide 23b; cytochrome P450, family 2, subfamily C, polypeptide 8", "tax_id": 9031, "disease": "", "pathway": " (gga:414841)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1527070;2375760;2470563", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M25469.1, SRR12888524.79783.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992639, SAMN03376184 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000231.1. On Sep 23, 2021 this sequence version replaced NP_001001757.1., [RefSeq]; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008392 arachidonate epoxygenase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0019373 epoxygenase P450 pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P20678-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20740-1", "uniprot_id": [ { "id": "OVOS_CHICK", "url": "https://www.uniprot.org/uniprot/P20740", "type": "external" } ], "mass": 166355.0, "length": 1473, "protein_name": "Ovostatin", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ovostatin; Ovomacroglobulin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "2470748;6408074;7535598;7680577", "class_list": "", "function": "Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced)., [UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P20740-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20785-1", "uniprot_id": [ { "id": "CO6A1_CHICK", "url": "https://www.uniprot.org/uniprot/P20785", "type": "external" } ], "mass": 107984.0, "length": 1019, "protein_name": "Collagen alpha-1(VI) chain", "gene_name": "COL6A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COL6A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-1(VI) chain", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396000)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1396681;1572359;2784434", "class_list": "", "function": "Collagen VI acts as a cell-binding protein., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005604 basement membrane;GO:0005589 collagen type VI trimer", "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0030198 extracellular matrix organization;GO:0009888 tissue development;GO:0009653 anatomical structure morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P20785-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21868-1", "uniprot_id": [ { "id": "CSK21_CHICK", "url": "https://www.uniprot.org/uniprot/P21868", "type": "external" } ], "mass": 45191.0, "length": 391, "protein_name": "Casein kinase II subunit alpha", "gene_name": "CSNK2A1", "organism": "Chicken", "refseq_name": "casein kinase II subunit alpha", "refseq_ac": [ { "id": "NP_001002242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002242", "type": "external" } ], "gene_names_uniprotkb": "CSNK2A1", "gene_names_refseq": "CSNK2A1", "protein_names_uniprotkb": "Casein kinase II subunit alpha; 2.7.11.1; CK II", "protein_names_refseq": "CK II; casein kinase 2, alpha 1 polypeptide; casein kinase II alpha subunit; casein kinase II subunit alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:432370)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14634006;18612635;1989988", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01000477.1, HAEK01017178.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000328.1. Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. It is involved in various cellular processes, including cell cycle control, apoptosis, and circadian rhythms. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Feb 2014]., [RefSeq]; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8 (By similarity). Plays an important role in the circadian clock function by phosphorylating BMAL1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Microtubule-associated protein that confers microtubule stability in a phosphorylation-independent manner (casein kinase CK2, alpha subunit), [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005956 protein kinase CK2 complex", "go_biological_process": "GO:0006302 double-strand break repair;GO:0016055 Wnt signaling pathway;GO:0048511 rhythmic process;GO:0051726 regulation of cell cycle;GO:1905337 positive regulation of aggrephagy", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P21868-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21869-1", "uniprot_id": [ { "id": "CSK22_CHICK", "url": "https://www.uniprot.org/uniprot/P21869", "type": "external" } ], "mass": 41246.0, "length": 350, "protein_name": "Casein kinase II subunit alpha'", "gene_name": "", "organism": "Chicken", "refseq_name": "casein kinase II subunit alpha'", "refseq_ac": [ { "id": "NP_001012709", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012709", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "CSNK2A2", "protein_names_uniprotkb": "Casein kinase II subunit alpha'; 2.7.11.1; CK II", "protein_names_refseq": "CK II; casein kinase 2, alpha prime polypeptide; casein kinase II subunit alpha'; casein kinase II, alpha' subunit", "tax_id": 9031, "disease": "", "pathway": " (gga:415626); (R-GGA-8939243)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "1989988", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M59457.1, HAEK01184647.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000247.1. On Mar 10, 2005 this sequence version replaced XP_413992.1., [RefSeq]; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha and alpha' chains contain the catalytic site. Participates in Wnt signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005956 protein kinase CK2 complex;GO:0031519 PcG protein complex", "go_biological_process": "GO:1905818 regulation of chromosome separation;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0016055 Wnt signaling pathway;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P21869-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23007-1", "uniprot_id": [ { "id": "CISY_CHICK", "url": "https://www.uniprot.org/uniprot/P23007", "type": "external" } ], "mass": 47378.0, "length": 433, "protein_name": "Citrate synthase, mitochondrial", "gene_name": "CS", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CS", "gene_names_refseq": "", "protein_names_uniprotkb": "Citrate synthase, mitochondrial; 2.3.3.1; Citrate (Si)-synthase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-372987)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "2043641;2337600", "class_list": "", "function": "Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0036440 citrate synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006101 citrate metabolic process;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P23007-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23228-1", "uniprot_id": [ { "id": "HMCS1_CHICK", "url": "https://www.uniprot.org/uniprot/P23228", "type": "external" } ], "mass": 57559.0, "length": 522, "protein_name": "Hydroxymethylglutaryl-CoA synthase, cytoplasmic", "gene_name": "HMGCS1", "organism": "Chicken", "refseq_name": "hydroxymethylglutaryl-CoA synthase, cytoplasmic", "refseq_ac": [ { "id": "NP_990742", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990742", "type": "external" } ], "gene_names_uniprotkb": "HMGCS1; HMGCS", "gene_names_refseq": "HMGCS1", "protein_names_uniprotkb": "Hydroxymethylglutaryl-CoA synthase, cytoplasmic; 2.3.3.10; 3-hydroxy-3-methylglutaryl coenzyme A synthase; HMG-CoA synthase", "protein_names_refseq": "3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); HMG-CoA synthase; hydroxymethylglutaryl-CoA synthase, cytoplasmic", "tax_id": 9031, "disease": "", "pathway": " (gga:396379)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1980405;7696316", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01001413.1, HAEK01034499.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000089.1. On Sep 23, 2021 this sequence version replaced NP_990742.1., [RefSeq]; Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" } ], "go_molecular_function": "GO:0004421 hydroxymethylglutaryl-CoA synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006084 acetyl-CoA metabolic process;GO:0006695 cholesterol biosynthetic process;GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P23228-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24052-1", "uniprot_id": [ { "id": "MK_CHICK", "url": "https://www.uniprot.org/uniprot/P24052", "type": "external" } ], "mass": 15579.0, "length": 142, "protein_name": "Midkine", "gene_name": "RIHB", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RIHB", "gene_names_refseq": "", "protein_names_uniprotkb": "Midkine; RI-HB; Retinoic acid-induced heparin-binding protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:423196)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1993066;2018506;2558016;7925417", "class_list": "", "function": "Has mitogenic activity, and neurite extension activity for PC12 cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0005604 basement membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0051781 positive regulation of cell division", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P24052-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24271-1", "uniprot_id": [ { "id": "RAG1_CHICK", "url": "https://www.uniprot.org/uniprot/P24271", "type": "external" } ], "mass": 119917.0, "length": 1041, "protein_name": "V(D)J recombination-activating protein 1", "gene_name": "RAG1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RAG1", "gene_names_refseq": "", "protein_names_uniprotkb": "V(D)J recombination-activating protein 1; RAG-1; RING-type E3 ubiquitin transferase RAG1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:423164)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1986866", "class_list": "", "function": "Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends. In addition to its endonuclease activity, RAG1 also acts as an E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H3. Histone H3 monoubiquitination is required for the joining step of V(D)J recombination (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0097519 DNA recombinase complex;GO:1905347 endodeoxyribonuclease complex", "go_biological_process": "GO:0002250 adaptive immune response;GO:0030183 B cell differentiation;GO:0006325 chromatin organization;GO:0033077 T cell differentiation in thymus;GO:0002331 pre-B cell allelic exclusion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P24271-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24343-1", "uniprot_id": [ { "id": "HXD12_CHICK", "url": "https://www.uniprot.org/uniprot/P24343", "type": "external" } ], "mass": 30014.0, "length": 266, "protein_name": "Homeobox protein Hox-D12", "gene_name": "HOXD12", "organism": "Chicken", "refseq_name": "homeobox protein Hox-D12", "refseq_ac": [ { "id": "NP_990580", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990580", "type": "external" } ], "gene_names_uniprotkb": "HOXD12; CHOX-4.7", "gene_names_refseq": "HOXD12", "protein_names_uniprotkb": "Homeobox protein Hox-D12; Chox-4.7; Chox-4F; Ghox-4.7; Homeobox protein Hox-4.7; Homeobox protein Hox-4F", "protein_names_refseq": "Ghox 4.7; Hox D12; chox-4.7; chox-4F; ghox-4.7; homeo box D12; homeobox protein Hox-4.7; homeobox protein Hox-4F; homeobox protein Hox-D12", "tax_id": 9031, "disease": "", "pathway": " (gga:396178)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11036080;1672266;1673231;1682126;22708793", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X62019.1, HAEL01007512.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992604, SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000236.1., [RefSeq]; Expression of Hoxd11/Hoxd12 in the chick hindlimb decreased and disappeared from the presumptive zeugopod region before cartilage formation., [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P24343-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24367-1", "uniprot_id": [ { "id": "PPIB_CHICK", "url": "https://www.uniprot.org/uniprot/P24367", "type": "external" } ], "mass": 22413.0, "length": 207, "protein_name": "Peptidyl-prolyl cis-trans isomerase B", "gene_name": "PPIB", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PPIB", "gene_names_refseq": "", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase B; 5.2.1.8; Cyclophilin B; PPIase B; Rotamase B; S-cyclophilin; SCYLP", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396447)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12753654;2040593", "class_list": "", "function": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0042470 melanosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006457 protein folding;GO:1904027 negative regulation of collagen fibril organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P24367-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24503-1", "uniprot_id": [ { "id": "CADH4_CHICK", "url": "https://www.uniprot.org/uniprot/P24503", "type": "external" } ], "mass": 100886.0, "length": 913, "protein_name": "Cadherin-4", "gene_name": "CDH4", "organism": "Chicken", "refseq_name": "cadherin-4 precursor", "refseq_ac": [ { "id": "NP_001004391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004391", "type": "external" } ], "gene_names_uniprotkb": "CDH4", "gene_names_refseq": "CDH4; cadherin-4", "protein_names_uniprotkb": "Cadherin-4; R-CAD; R-cadherin; Retinal cadherin", "protein_names_refseq": "R-CAD; R-cadherin; cadherin 4, type 1, R-cadherin (retinal); cadherin-4 precursor; retinal cadherin", "tax_id": 9031, "disease": "", "pathway": " (gga:419222)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15312902;1712604;18322922", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D14459.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000328.1. On Sep 17, 2004 this sequence version replaced XP_417399.1., [RefSeq]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development., [UniProtKB]; Expression of R-cadherin at the synaptic level on the somata and the proximal neurites of identified neuron populations has been traced selectively in the developing chicken visual system., [RefSeq, PubMed]; R-cadherin was complementarily expressed in surrounding areas of song nuclei., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0009986 cell surface;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P24503-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P24798-1", "uniprot_id": [ { "id": "AT1A3_CHICK", "url": "https://www.uniprot.org/uniprot/P24798", "type": "external" } ], "mass": 111284.0, "length": 1010, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-3", "gene_name": "ATP1A3", "organism": "Chicken", "refseq_name": "sodium/potassium-transporting ATPase subunit alpha-3", "refseq_ac": [ { "id": "NP_990806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990806", "type": "external" } ], "gene_names_uniprotkb": "ATP1A3", "gene_names_refseq": "ATP1A3", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-3; 7.2.2.13; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; Sodium pump subunit alpha-3", "protein_names_refseq": "ATPase, Na+/K+ transporting, alpha 3 polypeptide; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-3 subunit; sodium pump subunit alpha-3; sodium/potassium-transporting ATPase subunit alpha-3", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2171348", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M59960.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M59960.1. On Dec 9, 2006 this sequence version replaced XP_001235243.1., [RefSeq]; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.13", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0006883 intracellular sodium ion homeostasis;GO:0030007 intracellular potassium ion homeostasis;GO:0036376 sodium ion export across plasma membrane;GO:1990573 potassium ion import across plasma membrane;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P24798-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25207-1", "uniprot_id": [ { "id": "NFYB_CHICK", "url": "https://www.uniprot.org/uniprot/P25207", "type": "external" } ], "mass": 22585.0, "length": 205, "protein_name": "Nuclear transcription factor Y subunit beta", "gene_name": "NFYB", "organism": "Chicken", "refseq_name": "nuclear transcription factor Y subunit beta", "refseq_ac": [ { "id": "NP_001383173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383173", "type": "external" } ], "gene_names_uniprotkb": "NFYB; RCJMB04_7n24", "gene_names_refseq": "NF-YB; NFYB", "protein_names_uniprotkb": "Nuclear transcription factor Y subunit beta; CAAT box DNA-binding protein subunit B; NF-YB; Nuclear transcription factor Y subunit B", "protein_names_refseq": "CAAT box DNA-binding protein subunit B; CAAT-box DNA binding protein subunit B (NF-YB); nuclear transcription factor Y subunit B; nuclear transcription factor Y subunit beta; nuclear transcription factor Y, beta", "tax_id": 9031, "disease": "", "pathway": " (gga:396205)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1549471;15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267656.23948.1, HAEK01023873.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1., [RefSeq]; Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZL45", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016602 CCAAT-binding factor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P25207-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25324-1", "uniprot_id": [ { "id": "THTR_CHICK", "url": "https://www.uniprot.org/uniprot/P25324", "type": "external" } ], "mass": 32287.0, "length": 289, "protein_name": "Thiosulfate sulfurtransferase", "gene_name": "TST", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TST", "gene_names_refseq": "", "protein_names_uniprotkb": "Thiosulfate sulfurtransferase; 2.8.1.1; Rhodanese", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "2275748", "class_list": "", "function": "Catalyzes the transfer of sulfur ion from thiosulfate to cyanide, although other thiol compounds, besides cyanide, can act as sulfur ion acceptors (By similarity). It also has weak mercaptopyruvate sulfurtransferase (MST) activity (By similarity). Has a pivotal role in cyanide detoxification. Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.1", "type": "external" } ], "go_molecular_function": "GO:0016783 sulfurtransferase activity;GO:0008097 5S rRNA binding;GO:0004792 thiosulfate-cyanide sulfurtransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0051029 rRNA transport;GO:0035928 rRNA import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P25324-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26261-1", "uniprot_id": [ { "id": "SDC3_CHICK", "url": "https://www.uniprot.org/uniprot/P26261", "type": "external" } ], "mass": 43069.0, "length": 405, "protein_name": "Syndecan-3", "gene_name": "SDC3", "organism": "Chicken", "refseq_name": "syndecan-3 precursor", "refseq_ac": [ { "id": "NP_990714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990714", "type": "external" } ], "gene_names_uniprotkb": "SDC3", "gene_names_refseq": "SDC3; syn-3; syndecan-3", "protein_names_uniprotkb": "Syndecan-3", "protein_names_refseq": "syndecan 3 (N-syndecan); syndecan-3 precursor; syndecan-3 proteoglycan", "tax_id": 9031, "disease": "", "pathway": " (gga:396343)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "14991716;1565618;7729580", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01095382.1, M84910.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000339.1. On Sep 23, 2021 this sequence version replaced NP_990714.1., [RefSeq]; Cell surface proteoglycan that may bear both heparan sulfate and chondroitin sulfate. The multiple functional domains provide potential sites for mediating the adhesive cell-matrix interactions and cytoskeletal reorganization involved in limb chondrogenesis. Interaction with other matrix ligands as well as phosphorylation and shedding of the ectodomain might be involved in cell shape changes that occur during chondrogenesis. Furthermore, shedding of the ectodomain might break the adhesive interactions that promoted condensation, thus facilitating the deposition of cartilage matrix molecules., [UniProtKB]; Indian hedgehog and syndecan-3 have roles in chondrocyte proliferation and limb skeletogenesis, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 0, "predicted_o_glycosites": 8, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019838 growth factor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0016477 cell migration;GO:0030154 cell differentiation;GO:1900026 positive regulation of substrate adhesion-dependent cell spreading;GO:0003419 growth plate cartilage chondrocyte proliferation;GO:0035988 chondrocyte proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P26261-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26652-1", "uniprot_id": [ { "id": "TIMP3_CHICK", "url": "https://www.uniprot.org/uniprot/P26652", "type": "external" } ], "mass": 24505.0, "length": 212, "protein_name": "Metalloproteinase inhibitor 3", "gene_name": "TIMP3", "organism": "Chicken", "refseq_name": "metalloproteinase inhibitor 3 precursor", "refseq_ac": [ { "id": "NP_990818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990818", "type": "external" } ], "gene_names_uniprotkb": "TIMP3; IMP-3", "gene_names_refseq": "IMP-3; TIMP-3; TIMP3", "protein_names_uniprotkb": "Metalloproteinase inhibitor 3; 21 kDa protein of extracellular matrix; TIMP-3; Tissue inhibitor of metalloproteinases 3", "protein_names_refseq": "21 kDa protein of extracellular matrix; TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory); metalloproteinase inhibitor 3 precursor; metalloproteinase inhibitor 3; tissue inhibitor of metalloproteinase 3; tissue inhibitor of metalloproteinases 3", "tax_id": 9031, "disease": "", "pathway": " (gga:396483); (R-GGA-114608)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "1512267;1845973;26395636;27342592", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01003599.1, HAEK01043525.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992482, SAMN05341171 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1., [RefSeq]; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli., [UniProtKB]; Protein level of MMP-9 was diminished, while MMP-7 and TIMP-3 were elevated in the oviduct of growing birds. MMP-2 and TIMP-2 protein levels remained constant, with a slight increase in MMP-2 concentration just before reaching maturity., [RefSeq, PubMed]; Real-time polymerase chain reaction and western blot revealed different expression of MMP-2, -7, -9 and TIMP-2 and -3 on mRNA and protein levels, respectively, as well as activity of MMP-2 and -9 by activity assay in the oviduct parts., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005604 basement membrane", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0034097 response to cytokine;GO:0009725 response to hormone;GO:0010716 negative regulation of extracellular matrix disassembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P26652-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26932-1", "uniprot_id": [ { "id": "CNN1_CHICK", "url": "https://www.uniprot.org/uniprot/P26932", "type": "external" } ], "mass": 32361.0, "length": 292, "protein_name": "Calponin-1", "gene_name": "CNN1", "organism": "Chicken", "refseq_name": "calponin-1", "refseq_ac": [ { "id": "NP_990847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990847", "type": "external" } ], "gene_names_uniprotkb": "CNN1", "gene_names_refseq": "CNN1; Calponin-1", "protein_names_uniprotkb": "Calponin-1; Calponin, smooth muscle", "protein_names_refseq": "calponin 1, basic, smooth muscle; calponin alpha; calponin, smooth muscle; calponin-1", "tax_id": 9031, "disease": "", "pathway": " (gga:396522)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10873572;11839310;1639822;2071603;8130072;8276752;8280082;8454594", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M63559.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M63559.1., [RefSeq]; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P26933;Q9PSG0", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P26932-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27043-1", "uniprot_id": [ { "id": "ANGI_CHICK", "url": "https://www.uniprot.org/uniprot/P27043", "type": "external" } ], "mass": 15767.0, "length": 139, "protein_name": "Angiogenin", "gene_name": "ANG", "organism": "Chicken", "refseq_name": "angiogenin precursor", "refseq_ac": [ { "id": "NP_990590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990590", "type": "external" } ], "gene_names_uniprotkb": "ANG", "gene_names_refseq": "ANG; RNASE6", "protein_names_uniprotkb": "Angiogenin; 3.1.27.-; Ribonuclease A", "protein_names_refseq": "angiogenin precursor; angiogenin, ribonuclease, RNase A family, 5; leukocyte ribonuclease A-1; ribonuclease A/angiogenin", "tax_id": 9031, "disease": "", "pathway": " (gga:396194); (R-GGA-418990); (R-GGA-6798695); (R-GGA-6803157)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "1549365", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ395275.1, BU412255.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992484, SAMEA2812691 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ395275.1., [RefSeq]; Secreted ribonuclease that can either promote or restrict cell proliferation of target cells, depending on the context. Endocytosed in target cells via its receptor PLXNB2 and translocates to the cytoplasm or nucleus. Under stress conditions, localizes to the cytoplasm and promotes the assembly of stress granules (SGs): specifically cleaves a subset of tRNAs within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs), resulting in translation repression and inhibition of cell proliferation (By similarity). tiRNas also prevent formation of apoptosome, thereby promoting cell survival (By similarity). Preferentially cleaves RNAs between a pyrimidine and an adenosine residue, suggesting that it cleaves the anticodon loop of tRNA(Ala) (32-UUAGCAU-38) after positions 33 and 36. Cleaves a subset of tRNAs, including tRNA(Ala), tRNA(Glu), tRNA(Gly), tRNA(Lys), tRNA(Val), tRNA(His), tRNA(Asp) and tRNA(Sec). Under growth conditions and in differentiated cells, translocates to the nucleus and stimulates ribosomal RNA (rRNA) transcription, including that containing the initiation site sequences of 45S rRNA, thereby promoting cell growth and proliferation. Angiogenin induces vascularization of normal and malignant tissues via its ability to promote rRNA transcription (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0042803 protein homodimerization activity;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0032055 negative regulation of translation in response to stress;GO:0001525 angiogenesis;GO:0043066 negative regulation of apoptotic process;GO:0050830 defense response to Gram-positive bacterium;GO:0071425 hematopoietic stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P27043-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27921-1", "uniprot_id": [ { "id": "JUND_CHICK", "url": "https://www.uniprot.org/uniprot/P27921", "type": "external" } ], "mass": 33206.0, "length": 323, "protein_name": "Transcription factor JunD", "gene_name": "JUND", "organism": "Chicken", "refseq_name": "transcription factor JunD", "refseq_ac": [ { "id": "NP_001383604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383604", "type": "external" } ], "gene_names_uniprotkb": "JUND", "gene_names_refseq": "JUND", "protein_names_uniprotkb": "Transcription factor JunD; Transcription factor AP-1 subunit JunD", "protein_names_refseq": "Transcription factor jun-D; jun D proto-oncogene; transcription factor AP-1 subunit JunD; transcription factor JunD", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1923529;27795443", "class_list": "", "function": "JunD and AP-1 antagonize the induction of DAPK1 to promote the survival of v-Src-transformed cells. Publication Status: Online-Only, [RefSeq, PubMed]; PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000376.1, BX263510.4 and CB270908.1. On or before Oct 25, 2021 this sequence version replaced XP_040509717.1, XP_040548850.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0001221 transcription coregulator binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0035976 transcription factor AP-1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048545 response to steroid hormone", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P27921-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28173-1", "uniprot_id": [ { "id": "PUR1_CHICK", "url": "https://www.uniprot.org/uniprot/P28173", "type": "external" } ], "mass": 56257.0, "length": 510, "protein_name": "Amidophosphoribosyltransferase", "gene_name": "PPAT", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PPAT; GPAT", "gene_names_refseq": "", "protein_names_uniprotkb": "Amidophosphoribosyltransferase; 2.4.2.14; ATase; GPAT; Glutamine phosphoribosylpyrophosphate amidotransferase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:422743); (R-GGA-419140)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "11323713;17224163;2111814;2123487;2147474;4726295;8336716", "class_list": "", "function": "Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0004044 amidophosphoribosyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0009113 purine nucleobase biosynthetic process;GO:0006164 purine nucleotide biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P28173-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28568-1", "uniprot_id": [ { "id": "GTR3_CHICK", "url": "https://www.uniprot.org/uniprot/P28568", "type": "external" } ], "mass": 54175.0, "length": 496, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 3", "gene_name": "SLC2A3", "organism": "Chicken", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 3", "refseq_ac": [ { "id": "NP_990842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990842", "type": "external" } ], "gene_names_uniprotkb": "SLC2A3; GLUT3", "gene_names_refseq": "CEF-GT3; GLUT3; SLC2A14; SLC2A3", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 3; CEF-GT3; GLUT-3; Glucose transporter type 3", "protein_names_refseq": "GLUT-3; glucose transporter type 3; solute carrier family 2 (facilitated glucose transporter), member 3; solute carrier family 2, facilitated glucose transporter member 3", "tax_id": 9031, "disease": "", "pathway": " (gga:396517); (R-GGA-352832)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16268111;1875932;8161202;8589457", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01000612.1, SRR13267659.114768.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000015.1. On Sep 23, 2021 this sequence version replaced NP_990842.1., [RefSeq]; Facilitative glucose transporter. Can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport. Required for mesendoderm differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The extent of mRNA expression of GLUT1, GLUT2, GLUT3 and GLUT8 in chickens intrinsically lacking GLUT4 is reported., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005536 D-glucose binding;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043204 perikaryon;GO:0042995 cell projection", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0015757 galactose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P28568-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28682-1", "uniprot_id": [ { "id": "OPSB_CHICK", "url": "https://www.uniprot.org/uniprot/P28682", "type": "external" } ], "mass": 39657.0, "length": 361, "protein_name": "Blue-sensitive opsin", "gene_name": "", "organism": "Chicken", "refseq_name": "blue-sensitive opsin", "refseq_ac": [ { "id": "NP_990848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990848", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "CHK-2; OPN2SW", "protein_names_uniprotkb": "Blue-sensitive opsin; Blue cone photoreceptor pigment", "protein_names_refseq": "blue cone photoreceptor pigment; blue-sensitive opsin; opsin CHK-2", "tax_id": 9031, "disease": "", "pathway": " (gga:396525)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1385866;16260862", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M92037.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M92037.1., [RefSeq]; Study shows that in embryonic retinal cell cultures, rhodopsin, followed by violet and blue opsin expressions is highly dependent on serum, cell density and tissue conditions, while red and green opsins are more autonomous, [RefSeq, PubMed]; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P28682-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28684-1", "uniprot_id": [ { "id": "OPSV_CHICK", "url": "https://www.uniprot.org/uniprot/P28684", "type": "external" } ], "mass": 38720.0, "length": 347, "protein_name": "Violet-sensitive opsin", "gene_name": "", "organism": "Chicken", "refseq_name": "violet-sensitive opsin", "refseq_ac": [ { "id": "NP_990769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990769", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "OPN1SW; SWS1; opsin", "protein_names_uniprotkb": "Violet-sensitive opsin; Violet cone opsin; Violet cone photoreceptor pigment", "protein_names_refseq": "violet cone opsin; violet cone photoreceptor pigment; violet sensitive cone opsin; violet-sensitive opsin", "tax_id": 9031, "disease": "", "pathway": " (gga:396419)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1385866;16260862;32866531", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M92039.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M92039.1., [RefSeq]; Interactions of cone abundancies, opsin expression, and environmental lighting with emmetropization in chickens., [RefSeq, PubMed]; Study shows that in embryonic retinal cell cultures, rhodopsin, followed by violet and blue opsin expressions is highly dependent on serum, cell density and tissue conditions, while red and green opsins are more autonomous, [RefSeq, PubMed]; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P28684-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28685-1", "uniprot_id": [ { "id": "CNTN2_CHICK", "url": "https://www.uniprot.org/uniprot/P28685", "type": "external" } ], "mass": 113302.0, "length": 1036, "protein_name": "Contactin-2", "gene_name": "CNTN2", "organism": "Chicken", "refseq_name": "contactin-2 precursor", "refseq_ac": [ { "id": "NP_001004395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004395", "type": "external" } ], "gene_names_uniprotkb": "CNTN2", "gene_names_refseq": "AXONIN-1; CNTN2; contactin-2", "protein_names_uniprotkb": "Contactin-2; Axonin-1", "protein_names_refseq": "contactin 2 (axonal); contactin-2 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:419825)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10830169;1311675;18346270;23055510;7867620", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X63101.1, SRR13267656.8470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992440 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000356.1. On Sep 23, 2021 this sequence version replaced NP_001004395.1., [RefSeq]; Axon-associated cell adhesion molecule (AxCAM) which promotes neurite outgrowth by interaction with the AxCAM L1 (G4) of neuritic membrane. Contributes to the organization of axonal domains at nodes of Ranvier (By similarity)., [UniProtKB]; Axonin-1/TAG-1 is required for the navigation, but not for the elongation, of granule cell processes in the developing cerebellum in vivo Publication Status: Online-Only, [RefSeq, PubMed]; Depletion of Cntn2 in the retina reduces the ability of Cntn2-positive cells to restrict their arbors to appropriate sublaminae., [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0098552 side of membrane", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0007420 brain development;GO:0007411 axon guidance;GO:0007158 neuron cell-cell adhesion;GO:0097090 presynaptic membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P28685-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28686-1", "uniprot_id": [ { "id": "CCN3_CHICK", "url": "https://www.uniprot.org/uniprot/P28686", "type": "external" } ], "mass": 38268.0, "length": 351, "protein_name": "CCN family member 3", "gene_name": "CCN3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CCN3; NOV", "gene_names_refseq": "", "protein_names_uniprotkb": "CCN family member 3; Cellular communication network factor 3; Nephroblastoma-overexpressed gene protein; Protein NOV", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396204)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1309586", "class_list": "", "function": "Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of CCN3 gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0005921 gap junction", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0045597 positive regulation of cell differentiation;GO:0002062 chondrocyte differentiation;GO:0051240 positive regulation of multicellular organismal process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P28686-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29616-1", "uniprot_id": [ { "id": "MYSC_CHICK", "url": "https://www.uniprot.org/uniprot/P29616", "type": "external" } ], "mass": 128009.0, "length": 1102, "protein_name": "Myosin heavy chain, cardiac muscle isoform", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin heavy chain, cardiac muscle isoform", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1418675;1774788", "class_list": "", "function": "Muscle contraction., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032982 myosin filament;GO:0030016 myofibril;GO:0016460 myosin II complex", "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0055014 atrial cardiac muscle cell development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P29616-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30374-1", "uniprot_id": [ { "id": "RSFR_CHICK", "url": "https://www.uniprot.org/uniprot/P30374", "type": "external" } ], "mass": 15948.0, "length": 139, "protein_name": "Ribonuclease homolog", "gene_name": "", "organism": "Chicken", "refseq_name": "ribonuclease homolog precursor", "refseq_ac": [ { "id": "NP_001007943", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007943", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "RNASE4; RSFR", "protein_names_uniprotkb": "Ribonuclease homolog; 3.1.27.-; RSFR", "protein_names_refseq": "ribonuclease A family member 4; ribonuclease homolog precursor; ribonuclease homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:423668); (R-GGA-418990); (R-GGA-6798695); (R-GGA-6803157)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "1599460", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01013987.1, SRR12888534.116079.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992484, SAMEA2812691 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000227.1. On Dec 15, 2004 this sequence version replaced XP_421549.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P30374-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31043-1", "uniprot_id": [ { "id": "CD28_CHICK", "url": "https://www.uniprot.org/uniprot/P31043", "type": "external" } ], "mass": 25401.0, "length": 221, "protein_name": "T-cell-specific surface glycoprotein CD28 homolog", "gene_name": "CD28", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CD28", "gene_names_refseq": "", "protein_names_uniprotkb": "T-cell-specific surface glycoprotein CD28 homolog; CHT28", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396249)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8144954", "class_list": "", "function": "Possibly involved in T-cell activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0031295 T cell costimulation;GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway;GO:0050862 positive regulation of T cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P31043-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32017-1", "uniprot_id": [ { "id": "CO9A3_CHICK", "url": "https://www.uniprot.org/uniprot/P32017", "type": "external" } ], "mass": 63013.0, "length": 675, "protein_name": "Collagen alpha-3(IX) chain", "gene_name": "COL9A3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COL9A3", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen alpha-3(IX) chain", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1577778", "class_list": "", "function": "Collagen type IX is a minor cartilage non-fibrillar collagen. It is associated with type II collagen fibrils., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength", "go_cellular_component": "GO:0005604 basement membrane;GO:0005594 collagen type IX trimer", "go_biological_process": "GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P32017-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33145-1", "uniprot_id": [ { "id": "CADHK_CHICK", "url": "https://www.uniprot.org/uniprot/P33145", "type": "external" } ], "mass": 80613.0, "length": 732, "protein_name": "B-cadherin", "gene_name": "K-CAM", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "K-CAM", "gene_names_refseq": "", "protein_names_uniprotkb": "B-cadherin; K-CAM protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1763068;2026653", "class_list": "", "function": "Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. B-cadherin may have important functions in neurogenesis, in at least some epithelia, and in embryogenesis., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0009986 cell surface;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P33145-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33717-1", "uniprot_id": [ { "id": "IGF2_CHICK", "url": "https://www.uniprot.org/uniprot/P33717", "type": "external" } ], "mass": 20837.0, "length": 187, "protein_name": "Insulin-like growth factor 2", "gene_name": "IGF2", "organism": "Chicken", "refseq_name": "insulin-like growth factor 2 precursor", "refseq_ac": [ { "id": "NP_001025513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025513", "type": "external" } ], "gene_names_uniprotkb": "IGF2; IGF-2", "gene_names_refseq": "IGF-II; IGF2", "protein_names_uniprotkb": "Insulin-like growth factor 2; IGF-II; Insulin-like growth factor II", "protein_names_refseq": "insulin-like growth factor 2 (somatomedin A)prepro-IGF-IIprepro-insulin-like growth factor-II; insulin-like growth factor 2 (somatomedin A); insulin-like growth factor 2 precursor; insulin-like growth factor II; prepro-IGF-II; prepro-insulin-like growth factor-II", "tax_id": 9031, "disease": "", "pathway": " (gga:395097)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "14601723;15986892;16183342;1688912;17369538;20379887;26944971;28981085;3379351;8804558", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.207073.1, SRR13267659.78065.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1. On Oct 5, 2007 this sequence version replaced XP_421026.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Blood levels of IGF-II may be a more important functionary for chick embryonic development than IGF-I., [RefSeq, PubMed]; IGF1 and IGF2 might separately be more important for muscle and liver growth in chick embryonic development. Variation of IGFs expression during the incubation might be concerned with the methylation of gene promoter., [RefSeq, PubMed]; IGF2 is a candidate gene influencing growth and carcass traits, and has biallelic expression., [RefSeq, PubMed]; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling., [UniProtKB, UniProtKB]; These findings implied that polymorphisms within IGF1 and IGF2 genes could be in linkage disequilibrium with the actual causative mutations that affect growth and carcass traits., [RefSeq, PubMed]; These results suggest that the mechanism of action whereby IGFBP2 excess impairs long bone development is to inhibit IGF-I and IGF-II-mediated proliferation and matrix synthesis., [RefSeq, PubMed]; We found that MYOD transcription factor can upregulate miR-223 expression by binding to an E-box region of the gga-miR-223 gene promoter during avian myoblast differentiation. IGF2 and ZEB1 are two target genes of miR-223 Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P79890;Q7ZZT6", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005159 insulin-like growth factor receptor binding;GO:0005179 hormone activity;GO:0008083 growth factor activity;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0051781 positive regulation of cell division;GO:0046628 positive regulation of insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P33717-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P34822-1", "uniprot_id": [ { "id": "DSL1_CHICK", "url": "https://www.uniprot.org/uniprot/P34822", "type": "external" } ], "mass": 48626.0, "length": 427, "protein_name": "Dorsalin-1", "gene_name": "DSL1", "organism": "Chicken", "refseq_name": "dorsalin-1 precursor", "refseq_ac": [ { "id": "NP_990763", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990763", "type": "external" } ], "gene_names_uniprotkb": "DSL1", "gene_names_refseq": "DSL1; GDF2", "protein_names_uniprotkb": "Dorsalin-1; DSL-1", "protein_names_refseq": "DSL-1; dorsalin-1 precursor; dorsalin-1", "tax_id": 9031, "disease": "", "pathway": " (gga:396412)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7916656", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L12032.1, CN221680.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L12032.1., [RefSeq]; Appears to regulate cell differentiation within the neural tube. May regulate the differentiation of cell types along the dorsoventral axis of the neural tube, acting in conjunction with distinct ventralizing signals from the notochord and floor plate. Controls the cell differentiation in the neural tube in several ways: (1) promotes the differentiation of cell types that derive from the dorsal neural tube. (2) ensures that the dorsal neural tube is refractory to ventralizing species from the notochord. (3) can diffuse and influence the fate of cells in more ventral regions of the neural tube., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030858 positive regulation of epithelial cell differentiation;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006879 intracellular iron ion homeostasis;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P34822-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35062-1", "uniprot_id": [ { "id": "H2A3_CHICK", "url": "https://www.uniprot.org/uniprot/P35062", "type": "external" } ], "mass": 13966.0, "length": 129, "protein_name": "Histone H2A-III", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H2A-III", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "12450536;2713375;3267232;8406011", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q92016", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P35062-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35431-1", "uniprot_id": [ { "id": "CAV1_CHICK", "url": "https://www.uniprot.org/uniprot/P35431", "type": "external" } ], "mass": 20447.0, "length": 178, "protein_name": "Caveolin-1", "gene_name": "CAV1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CAV1", "gene_names_refseq": "", "protein_names_uniprotkb": "Caveolin-1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:373996)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1279683", "class_list": "", "function": "May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G protein alpha subunits and can functionally regulate their activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019901 protein kinase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0030154 cell differentiation;GO:0031295 T cell costimulation;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0001937 negative regulation of endothelial cell proliferation;GO:0070836 caveola assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35431-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35915-1", "uniprot_id": [ { "id": "HMGCL_CHICK", "url": "https://www.uniprot.org/uniprot/P35915", "type": "external" } ], "mass": 31436.0, "length": 298, "protein_name": "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "gene_name": "HMGCL", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HMGCL", "gene_names_refseq": "", "protein_names_uniprotkb": "Hydroxymethylglutaryl-CoA lyase, mitochondrial; 3-hydroxy-3-methylglutarate-CoA lyase; 4.1.3.4; HL; HMG-CoA lyase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8440722", "class_list": "", "function": "Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004419 hydroxymethylglutaryl-CoA lyase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome", "go_biological_process": "GO:0046951 ketone body biosynthetic process;GO:0006552 L-leucine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P35915-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36196-1", "uniprot_id": [ { "id": "ACES_CHICK", "url": "https://www.uniprot.org/uniprot/P36196", "type": "external" } ], "mass": 83020.0, "length": 767, "protein_name": "Acetylcholinesterase", "gene_name": "ACHE", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ACHE", "gene_names_refseq": "", "protein_names_uniprotkb": "Acetylcholinesterase; 3.1.1.7; AChE", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8049273", "class_list": "", "function": "Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.7", "type": "external" } ], "go_molecular_function": "GO:0003990 acetylcholinesterase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0019695 choline metabolic process;GO:0006581 acetylcholine catabolic process;GO:0010842 retina layer formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P36196-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36197-1", "uniprot_id": [ { "id": "ZEB1_CHICK", "url": "https://www.uniprot.org/uniprot/P36197", "type": "external" } ], "mass": 123151.0, "length": 1114, "protein_name": "Zinc finger E-box-binding homeobox 1", "gene_name": "ZEB1", "organism": "Chicken", "refseq_name": "zinc finger E-box-binding homeobox 1", "refseq_ac": [ { "id": "NP_990462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990462", "type": "external" } ], "gene_names_uniprotkb": "ZEB1; TCF8", "gene_names_refseq": "TCF8; ZEB1", "protein_names_uniprotkb": "Zinc finger E-box-binding homeobox 1; Delta EF1; Delta-crystallin enhancer-binding factor; TCF-8; Transcription factor 8", "protein_names_refseq": "TCF-8; delta EF1; delta-crystallin enhancer-binding factor; deltaEF1; transcription factor 8 (represses interleukin 2 expression); zinc finger E-box-binding homeobox 1", "tax_id": 9031, "disease": "", "pathway": " (gga:396029)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "19008385;23765923;26691438;28981085;34116118;7904558;8964504", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D14313.1, KY362200.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000036.1. On Sep 23, 2021 this sequence version replaced NP_990462.1., [RefSeq]; Acts as a transcriptional repressor. Positively regulates neuronal differentiation. Represses transcription by binding to the E box-containing promoter. Binds to delta 1-crystallin enhancer core and represses lens-specific transcription (PubMed:7904558). It also binds many other non-lens specific DNA sequences (PubMed:7904558)., [UniProtKB, PubMed]; Epigenetic modification cooperates with Zeb1 transcription factor to regulate Bmp4 to promote chicken PGCs formation., [RefSeq, PubMed]; Expression of Sox10, the major transcription factor that regulates neural crest development, was also decreased by the shRNAs against deltaEF1 or Sip1., [RefSeq, PubMed]; MiR-150 and miR-200c play an important role in human endothelial lineage specification and chick embryonic vasculogenesis by targeting ZEB1., [RefSeq, PubMed]; These findings indicate that the chicken infectious anemia virus promoter activity can be affected directly or indirectly by COUP-TF1 and deltaEF1., [RefSeq, PubMed]; We found that MYOD transcription factor can upregulate miR-223 expression by binding to an E-box region of the gga-miR-223 gene promoter during avian myoblast differentiation. IGF2 and ZEB1 are two target genes of miR-223 Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O42408", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045666 positive regulation of neuron differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P36197-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40220-1", "uniprot_id": [ { "id": "RABP1_CHICK", "url": "https://www.uniprot.org/uniprot/P40220", "type": "external" } ], "mass": 15663.0, "length": 137, "protein_name": "Cellular retinoic acid-binding protein 1", "gene_name": "CRABP1", "organism": "Chicken", "refseq_name": "cellular retinoic acid-binding protein 1", "refseq_ac": [ { "id": "NP_001025710", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025710", "type": "external" } ], "gene_names_uniprotkb": "CRABP1", "gene_names_refseq": "CRABP-I; CRABP1; cCRABP-I", "protein_names_uniprotkb": "Cellular retinoic acid-binding protein 1; CRABP-I; Cellular retinoic acid-binding protein I", "protein_names_refseq": "cellular retinoic acid binding protein I (CRABP-I) homologue; cellular retinoic acid-binding protein 1; cellular retinoic acid-binding protein I", "tax_id": 9031, "disease": "", "pathway": " (gga:374211)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15642085;17706616;1966833;9608736", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01000032.1, BU254213.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000245.1. On Aug 8, 2005 this sequence version replaced XP_413744.1., [RefSeq]; Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors., [UniProtKB]; Our data show immunoreactivity of CRABP-I in the tectal anlage at E2.5 and during the entire period of embryonic development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O42405;Q5R2I9", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0019841 retinol binding;GO:0016918 retinal binding;GO:0005501 retinoid binding;GO:0001972 retinoic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030424 axon;GO:0043005 neuron projection;GO:0070852 cell body fiber", "go_biological_process": "GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P40220-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41239-1", "uniprot_id": [ { "id": "CSK_CHICK", "url": "https://www.uniprot.org/uniprot/P41239", "type": "external" } ], "mass": 50751.0, "length": 450, "protein_name": "Tyrosine-protein kinase CSK", "gene_name": "CSK", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CSK", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein kinase CSK; 2.7.10.4; C-Src kinase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396396)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1372437;7935444", "class_list": "", "function": "Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs). Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0060368 regulation of Fc receptor mediated stimulatory signaling pathway;GO:0002250 adaptive immune response;GO:0034332 adherens junction organization;GO:0051239 regulation of multicellular organismal process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P41239-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42165-1", "uniprot_id": [ { "id": "IFNA1_CHICK", "url": "https://www.uniprot.org/uniprot/P42165", "type": "external" } ], "mass": 22116.0, "length": 193, "protein_name": "Interferon type A1/A2", "gene_name": "IFNA1; IFNA2", "organism": "Chicken", "refseq_name": "interferon type A3 precursor", "refseq_ac": [ { "id": "NP_990758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990758", "type": "external" } ], "gene_names_uniprotkb": "IFNA1; IFNA2", "gene_names_refseq": "IFN-alpha; IFN-gamma; IFNA1; IFNA2; IFNA3; IFNA6; IFNA", "protein_names_uniprotkb": "Interferon type A1/A2", "protein_names_refseq": "IFN alpha; interferon alpha; interferon type A1/A2; interferon type A3 precursor; interferon type A3", "tax_id": 9031, "disease": "", "pathway": " (gga:100857744); (gga:100857947); (gga:100858177); (gga:100859032); (gga:396398)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "15699590;21354949;23427151;24068929;26872625;7521382;8631799", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: SRR12888550.37741.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U07868.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data suggest that down-regulation of circular viral DNA transcription is primary mechanism of IFN-alpha against duck hepatitis B virus; this process requires protein biosynthesis., [RefSeq, PubMed]; Expression of Gallus interferon-alpha in a baculovirus system., [RefSeq, PubMed]; Fpv014 contribute to increased resistance to chicken alpha interferon response., [RefSeq, PubMed]; Has antiviral activities., [UniProtKB]; RNA sequencing results revealed that the chicken IFNA3 was more upregulated in the intestinal mucosal layer of Necrotic enteritis induced chicken lines that are resistant and sensitive to avian leukosis and Marek's disease., [RefSeq, PubMed]; The results show that cells stimulated to produce IFN-alpha and IFN-gamma enter the circulating blood but those stimulated to produce IL-2 do not, or in very low number, and the IFN responses to both vaccines are the same., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P42165-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43031-1", "uniprot_id": [ { "id": "INHA_CHICK", "url": "https://www.uniprot.org/uniprot/P43031", "type": "external" } ], "mass": 35853.0, "length": 329, "protein_name": "Inhibin alpha chain", "gene_name": "INHA", "organism": "Chicken", "refseq_name": "inhibin alpha chain precursor", "refseq_ac": [ { "id": "NP_001026428", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026428", "type": "external" } ], "gene_names_uniprotkb": "INHA", "gene_names_refseq": "INHA", "protein_names_uniprotkb": "Inhibin alpha chain", "protein_names_refseq": "inhibin alpha chain precursor; inhibin alpha chain", "tax_id": 9031, "disease": "", "pathway": " (gga:424197)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22267736;8399835", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267654.144617.1, SRR13267651.11222.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000236.1. On Aug 8, 2005 this sequence version replaced XP_422043.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Inhibin alpha-subunit N terminus interacts with activin type IB receptor to disrupt activin signaling., [RefSeq, PubMed]; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q90708", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0043512 inhibin A complex;GO:0005615 extracellular space", "go_biological_process": "GO:0048731 system development;GO:0046880 regulation of follicle-stimulating hormone secretion;GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway;GO:0051241 negative regulation of multicellular organismal process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P43031-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43233-1", "uniprot_id": [ { "id": "CATB_CHICK", "url": "https://www.uniprot.org/uniprot/P43233", "type": "external" } ], "mass": 37587.0, "length": 340, "protein_name": "Cathepsin B", "gene_name": "CTSB", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CTSB", "gene_names_refseq": "", "protein_names_uniprotkb": "Cathepsin B; 3.4.22.1; Cathepsin B1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7647095", "class_list": "", "function": "Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005764 lysosome", "go_biological_process": "GO:0060561 apoptotic process involved in morphogenesis;GO:0051603 proteolysis involved in protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P43233-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43449-1", "uniprot_id": [ { "id": "CCNA2_CHICK", "url": "https://www.uniprot.org/uniprot/P43449", "type": "external" } ], "mass": 44080.0, "length": 395, "protein_name": "Cyclin-A2", "gene_name": "CCNA2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CCNA2; CCNA; CYCA", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclin-A2; Cyclin-A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396172)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8282760", "class_list": "", "function": "Essential for the control of the cell cycle at G1/S and G2/M transition (By similarity). Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0051301 cell division;GO:0000086 G2/M transition of mitotic cell cycle;GO:0000082 G1/S transition of mitotic cell cycle;GO:0044843 cell cycle G1/S phase transition", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P43449-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43679-1", "uniprot_id": [ { "id": "ACHB3_CHICK", "url": "https://www.uniprot.org/uniprot/P43679", "type": "external" } ], "mass": 52276.0, "length": 455, "protein_name": "Neuronal acetylcholine receptor subunit beta-3", "gene_name": "CHRNB3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CHRNB3", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit beta-3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7852408", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit. Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNA6, CHRNB2 and CHRNB4. Modulates receptor assembly and increases receptor sensitivity to nicotine when associated with CHRNB2, CHRNA4 and/or CHRNA6 as well as CHRNA3 and CHRNB4. Seems to play a role in nicotine addiction., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0095500 acetylcholine receptor signaling pathway;GO:0034220 monoatomic ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P43679-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43692-1", "uniprot_id": [ { "id": "GATA5_CHICK", "url": "https://www.uniprot.org/uniprot/P43692", "type": "external" } ], "mass": 41859.0, "length": 391, "protein_name": "Transcription factor GATA-5", "gene_name": "GATA5", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GATA5", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor GATA-5; GATA-binding factor 5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15329343;8083222", "class_list": "", "function": "Probably involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045165 cell fate commitment", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P43692-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46156-1", "uniprot_id": [ { "id": "GLL1_CHICK", "url": "https://www.uniprot.org/uniprot/P46156", "type": "external" } ], "mass": 7209.0, "length": 65, "protein_name": "Gallinacin-1", "gene_name": "GAL1", "organism": "Chicken", "refseq_name": "gallinacin-1 alpha precursor", "refseq_ac": [ { "id": "NP_990324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990324", "type": "external" } ], "gene_names_uniprotkb": "GAL1", "gene_names_refseq": "AvBD1; GAL 1; GAL1", "protein_names_uniprotkb": "Gallinacin-1; Beta-defensin 1; Gal-1", "protein_names_refseq": "Gal 1-alpha; antimicrobial peptide 1; antimicrobial peptide CHP2; beta-defensin 1 antimicrobial peptide; chicken heterophil peptide 2; gal-1 alpha; gallinacin 1; gallinacin-1 alpha precursor; gallinacin-1 alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:395841); (R-GGA-1461957); (R-GGA-1461973)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "15148642;15310403;16394622;17244739;32186462;8150085;9745666", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF033335.1, BU472812.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2812691, SAMEA2812692 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF033335.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Has bactericidal activity. Potent activity against E.coli ML-35, L.monocytogenes EGD and C.albicans., [UniProtKB, PubMed]; The chicken genome encodes only beta-defensins. The 13 chicken beta-defensin genes are clustered densely within a 86-Kb distance on the chromosome 3q3.5-q3.7. The deduced peptides share the characteristic defensin motif. Publication Status: Online-Only, [RefSeq, PubMed]; Tissue-, age- and dose-dependent changes in avian beta-defensin and LEAP2 mRNA abundance in the intestines of Salmonella Typhimurium challenged broilers., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q09MK1;Q0PWH4;Q6B9W7;Q6GXJ4", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0006952 defense response;GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism;GO:0050832 defense response to fungus", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P46156-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46157-1", "uniprot_id": [ { "id": "GLL1A_CHICK", "url": "https://www.uniprot.org/uniprot/P46157", "type": "external" } ], "mass": 7286.0, "length": 65, "protein_name": "Gallinacin-1 alpha", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Gallinacin-1 alpha; Antimicrobial peptide CHP2; Chicken heterophil peptide 2; Gal-1 alpha", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1461957); (R-GGA-1461973)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "11254635;7964174;8150085", "class_list": "", "function": "Has bactericidal activity. Potent activity against E.coli ML-35, L.monocytogenes EGD and C.albicans., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P80390;Q09MR8;Q9DG59", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0030141 secretory granule", "go_biological_process": "GO:0006952 defense response;GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism;GO:0050832 defense response to fungus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P46157-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48433-1", "uniprot_id": [ { "id": "SOX3_CHICK", "url": "https://www.uniprot.org/uniprot/P48433", "type": "external" } ], "mass": 34456.0, "length": 312, "protein_name": "Transcription factor SOX-3", "gene_name": "SOX3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SOX3", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription factor SOX-3; cSox3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "14517545;7748786", "class_list": "", "function": "Transcription factor that may function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045665 negative regulation of neuron differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48433-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48463-1", "uniprot_id": [ { "id": "PP2AA_CHICK", "url": "https://www.uniprot.org/uniprot/P48463", "type": "external" } ], "mass": 35563.0, "length": 309, "protein_name": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "gene_name": "PPP2CA", "organism": "Chicken", "refseq_name": "serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "refseq_ac": [ { "id": "NP_990455", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990455", "type": "external" } ], "gene_names_uniprotkb": "PPP2CA", "gene_names_refseq": "PPP2CA; PPP2CB", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; 3.1.3.16; PP2A-alpha", "protein_names_refseq": "PP2A-alpha; phosphatase 2A catalytic subunit; protein phosphatase 2, catalytic subunit, beta isozyme; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform", "tax_id": 9031, "disease": "", "pathway": " (gga:396021)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01008111.1, D17531.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992559 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000073.1., [RefSeq]; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase (By similarity). Key mediator of a quality checkpoint during transcription elongation as part of the Integrator-PP2A (INTAC) complex. The INTAC complex drives premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: within the INTAC complex, PPP2CA catalyzes dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, thereby preventing transcriptional elongation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0004722 protein serine/threonine phosphatase activity;GO:0180006 RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity;GO:0180007 RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005829 cytosol;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0035331 negative regulation of hippo signaling;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly;GO:0160240 RNA polymerase II transcription initiation surveillance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P48463-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48804-1", "uniprot_id": [ { "id": "FGF4_CHICK", "url": "https://www.uniprot.org/uniprot/P48804", "type": "external" } ], "mass": 21642.0, "length": 194, "protein_name": "Fibroblast growth factor 4", "gene_name": "FGF4", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FGF4; FGF-4", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibroblast growth factor 4; FGF-4; HBGF-4; Heparin-binding growth factor 4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7935794", "class_list": "", "function": "Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0051781 positive regulation of cell division;GO:0030334 regulation of cell migration;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P48804-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49285-1", "uniprot_id": [ { "id": "MTR1A_CHICK", "url": "https://www.uniprot.org/uniprot/P49285", "type": "external" } ], "mass": 39896.0, "length": 353, "protein_name": "Melatonin receptor type 1A", "gene_name": "", "organism": "Chicken", "refseq_name": "melatonin receptor type 1A", "refseq_ac": [ { "id": "NP_990693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990693", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "CKA; MTNR1A; Mel1a; mel-1A-R", "protein_names_uniprotkb": "Melatonin receptor type 1A; CKA; Mel-1A-R; Mel1a receptor", "protein_names_refseq": "Mel-1a melatonin receptor; mel1a receptor; melatonin receptor type 1A", "tax_id": 9031, "disease": "", "pathway": " (gga:396319); (R-GGA-373076); (R-GGA-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "24209505;7576645", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U31820.1, EF197907.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMN05341171 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1., [RefSeq]; High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity (By similarity)., [UniProtKB]; Results suggest that melatonin mediates green light-induced bursal B-lymphocyte proliferation through melatonin receptor subrypes Mel1c and Mel1a receptors but not Mel1b receptors by activating the cyclic AMP/protein kinase A pathway, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0042562 hormone binding;GO:0008502 melatonin receptor activity;GO:1904408 melatonin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0045820 negative regulation of glycolytic process;GO:0046325 negative regulation of D-glucose import", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P49285-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49416-1", "uniprot_id": [ { "id": "SDC4_CHICK", "url": "https://www.uniprot.org/uniprot/P49416", "type": "external" } ], "mass": 21502.0, "length": 197, "protein_name": "Syndecan-4", "gene_name": "SDC4", "organism": "Chicken", "refseq_name": "syndecan-4 precursor", "refseq_ac": [ { "id": "NP_001007870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007870", "type": "external" } ], "gene_names_uniprotkb": "SDC4", "gene_names_refseq": "SDC4; syndecan-4", "protein_names_uniprotkb": "Syndecan-4", "protein_names_refseq": "heparan sulfate proteoglycan; syndecan 4 (amphiglycan, ryudocan); syndecan-4 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:419184)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10633082;8276871", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01036348.1, HAEL01001931.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000328.1. On Dec 15, 2004 this sequence version replaced XP_417362.1., [RefSeq]; Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 2, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0016477 cell migration;GO:0061098 positive regulation of protein tyrosine kinase activity;GO:1903078 positive regulation of protein localization to plasma membrane;GO:0090630 activation of GTPase activity;GO:1903076 regulation of protein localization to plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P49416-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49581-1", "uniprot_id": [ { "id": "ACHA6_CHICK", "url": "https://www.uniprot.org/uniprot/P49581", "type": "external" } ], "mass": 57495.0, "length": 494, "protein_name": "Neuronal acetylcholine receptor subunit alpha-6", "gene_name": "CHRNA6", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CHRNA6", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396321)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9203638", "class_list": "", "function": "Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA6 forms pentameric channels with CHRNB2, CHRNB3 and CHRNA4 that exhibit high sensitivity to ACh and nicotine and are predominantly expressed in only a few brain areas, including dopaminergic neurons, norepirephrine neurons and cells of the visual system (PubMed:9203638). nAChrs containing CHRNA6 subunits mediate endogenous cholinergic modulation of dopamine and gamma-aminobutyric acid (GABA) release in response to nicotine at nerve terminals., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q90709", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse;GO:0045211 postsynaptic membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0035094 response to nicotine;GO:0035095 behavioral response to nicotine;GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P49581-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P49708-1", "uniprot_id": [ { "id": "IFNG_CHICK", "url": "https://www.uniprot.org/uniprot/P49708", "type": "external" } ], "mass": 18953.0, "length": 164, "protein_name": "Interferon gamma", "gene_name": "IFNG", "organism": "Chicken", "refseq_name": "interferon gamma precursor", "refseq_ac": [ { "id": "NP_990480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990480", "type": "external" } ], "gene_names_uniprotkb": "IFNG", "gene_names_refseq": "IFNG; INFG", "protein_names_uniprotkb": "Interferon gamma; IFN-gamma", "protein_names_refseq": "IFN-gamma; Interferon-gamma level; interferon gamma precursor; interferon-gama", "tax_id": 9031, "disease": "", "pathway": " (gga:396054); (R-GGA-877300); (R-GGA-877312); (R-GGA-9732724)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "17888472;17899460;25638972;25673902;8590305;8898958;9511740", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X99774.1, AY705909.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Knockdown of IFN-gamma did not seem to fully abrogate vaccine-induced protection against Marek's disease in chickens., [RefSeq, PubMed]; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity)., [UniProtKB]; The dose-response effects of supplemental dietary chormium on interferon-gamma expression in response to Newcastle disease virus vaccine in broiler chickens is reported., [RefSeq, PubMed]; The effect of class B CpG ODN administered by subcutaneous or intraocular injection on cytokine expression in chickens is reported., [RefSeq, PubMed]; The pivotal role of chicken interferon-gamma in the pathogenesis and immunosuppression of infectious bursal disease virus infection in in vivo, ex vivo and in vitro experiments are reported., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "D3GGX1;Q53YS2", "ec_number_list": [], "go_molecular_function": "GO:0005133 type II interferon receptor binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032834 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response;GO:0060552 positive regulation of fructose 1,6-bisphosphate metabolic process;GO:0060557 positive regulation of vitamin D biosynthetic process;GO:0032747 positive regulation of interleukin-23 production;GO:0032700 negative regulation of interleukin-17 production", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P49708-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50141-1", "uniprot_id": [ { "id": "GCH1_CHICK", "url": "https://www.uniprot.org/uniprot/P50141", "type": "external" } ], "mass": 26115.0, "length": 236, "protein_name": "GTP cyclohydrolase 1", "gene_name": "GCH1", "organism": "Chicken", "refseq_name": "GTP cyclohydrolase 1", "refseq_ac": [ { "id": "NP_990554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990554", "type": "external" } ], "gene_names_uniprotkb": "GCH1", "gene_names_refseq": "GCH1", "protein_names_uniprotkb": "GTP cyclohydrolase 1; 3.5.4.16; GTP cyclohydrolase I; GTP-CH-I", "protein_names_refseq": "GTP cyclohydrolase 1 (dopa-responsive dystonia); GTP cyclohydrolase 1; GTP cyclohydrolase I; GTP-CH-I", "tax_id": 9031, "disease": "", "pathway": " (gga:396146)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7542887", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267654.42774.1, HAEK01037924.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000215.1. On Sep 23, 2021 this sequence version replaced NP_990554.1., [RefSeq]; May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis. May modify pain sensitivity and persistence., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.16", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0003934 GTP cyclohydrolase I activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0006729 tetrahydrobiopterin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P50141-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50478-1", "uniprot_id": [ { "id": "AMPH_CHICK", "url": "https://www.uniprot.org/uniprot/P50478", "type": "external" } ], "mass": 75205.0, "length": 682, "protein_name": "Amphiphysin", "gene_name": "AMPH", "organism": "Chicken", "refseq_name": "amphiphysin", "refseq_ac": [ { "id": "NP_001004398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004398", "type": "external" } ], "gene_names_uniprotkb": "AMPH", "gene_names_refseq": "AMPH", "protein_names_uniprotkb": "Amphiphysin", "protein_names_refseq": "amphiphysin (Stiff-Man syndrome with breast cancer 128kDa autoantigen); amphiphysin", "tax_id": 9031, "disease": "", "pathway": " (gga:420761)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1628617", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X60422.1, ERR2368565.188668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000037.1. On Sep 23, 2021 this sequence version replaced NP_001004398.1., [RefSeq]; May participate in mechanisms of regulated exocytosis in synapses and certain endocrine cell types. May control the properties of the membrane associated cytoskeleton., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle;GO:0044306 neuron projection terminus", "go_biological_process": "GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P50478-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50890-1", "uniprot_id": [ { "id": "RSSA_CHICK", "url": "https://www.uniprot.org/uniprot/P50890", "type": "external" } ], "mass": 33021.0, "length": 296, "protein_name": "Small ribosomal subunit protein uS2", "gene_name": "RPSA", "organism": "Chicken", "refseq_name": "small ribosomal subunit protein uS2", "refseq_ac": [ { "id": "NP_001007824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007824", "type": "external" } ], "gene_names_uniprotkb": "RPSA; LAMR1", "gene_names_refseq": "37LRP; 67LR; DMRT1; LAMR1; LBP/p40; LRP/LR; RPSA2; RPSAP58; RPSA; lamR", "protein_names_uniprotkb": "Small ribosomal subunit protein uS2; 37 kDa laminin receptor precursor; 37/67 kDa laminin receptor; 37LRP; 40S ribosomal protein SA; 67 kDa laminin receptor; 67LR; LBP/p40; LRP/LR; LamR; Laminin receptor 1; Laminin-binding protein precursor p40", "protein_names_refseq": "37kD Laminin receptor; 40S ribosomal protein SA; ribosomal protein SA pseudogene 58; small ribosomal subunit protein uS2", "tax_id": 9031, "disease": "", "pathway": " (gga:395181); (R-GGA-1799339); (R-GGA-72649); (R-GGA-72695); (R-GGA-72702); (R-GGA-72706); (R-GGA-975956); (R-GGA-975957); (R-GGA-9954714); (R-GGA-9954716)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "8985115", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CF251566.1, CN210807.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992484 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000037.1. On or before Oct 3, 2010 this sequence version replaced XP_001235320.1, XP_418817.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043236 laminin binding;GO:0005055 laminin receptor activity;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P50890-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51641-1", "uniprot_id": [ { "id": "CNTFR_CHICK", "url": "https://www.uniprot.org/uniprot/P51641", "type": "external" } ], "mass": 40308.0, "length": 362, "protein_name": "Ciliary neurotrophic factor receptor subunit alpha", "gene_name": "CNTFR", "organism": "Chicken", "refseq_name": "ciliary neurotrophic factor receptor subunit alpha precursor", "refseq_ac": [ { "id": "NP_990359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990359", "type": "external" } ], "gene_names_uniprotkb": "CNTFR", "gene_names_refseq": "CNTFR", "protein_names_uniprotkb": "Ciliary neurotrophic factor receptor subunit alpha; CNTF receptor subunit alpha; CNTFR-alpha; GPA receptor subunit alpha; GPAR-alpha; Growth-promoting activity receptor subunit alpha", "protein_names_refseq": "CNTF receptor subunit alpha; CNTFR-alpha; GPA receptor subunit alpha; GPAR-alpha; GPARalpha; ciliary neurotrophic factor receptor subunit alpha precursor; ciliary neurotrophic factor receptor subunit alpha; growth promoting activity (GPA) receptor alpha; growth-promoting activity receptor subunit alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:395885)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7595532;7671828", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267647.22207.1, SRR13267660.961.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000087.1. On Oct 29, 2021 this sequence version replaced NP_990359.1., [RefSeq]; Functions either as a membrane-anchored non-signaling receptor via a GPI anchor or, after proteolytic release, as a soluble ligand-binding chaperone, and mediates signaling of CNTF-related cytokines, including ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine factor 1 (CLCF1), and the heterodimeric cytokine formed by CLCF1 and the cytokine receptor-like factor 1 (CRLF1) (PubMed:7671828). Involved namely in cell survival of motor neurons and regulation of oligodendrocyte progenitor proliferation. Functions within the ciliary neurotrophic factor receptor (CNTFR) complex as a membrane-anchored non-signaling receptor subunit associated with two other signaling receptor subunits IL6ST/gp130 and LIFR. Alternatively functions as a soluble ligand-binding chaperone that binds ligand in the extracellular space, forming a cytokine complex which is delivered to the IL6ST/gp130 and LIFR signaling receptor subunits. Mechanistically, ligand binding to the CNTFR induces dimerization of the IL6ST/gp130 and LIFR (or IL27RA/WSX1 in the case of MT-RNR2/humanin), which activate JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (or IL27RA/WSX1). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1) (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004897 ciliary neurotrophic factor receptor activity;GO:0004921 interleukin-11 receptor activity;GO:0019970 interleukin-11 binding;GO:0005125 cytokine activity", "go_cellular_component": "GO:0070110 ciliary neurotrophic factor receptor complex;GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0097059 CNTFR-CLCF1 complex", "go_biological_process": "GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0070446 negative regulation of oligodendrocyte progenitor proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51641-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52186-1", "uniprot_id": [ { "id": "KCNJ2_CHICK", "url": "https://www.uniprot.org/uniprot/P52186", "type": "external" } ], "mass": 48518.0, "length": 427, "protein_name": "Inward rectifier potassium channel 2", "gene_name": "KCNJ2", "organism": "Chicken", "refseq_name": "inward rectifier potassium channel 2", "refseq_ac": [ { "id": "NP_990701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990701", "type": "external" } ], "gene_names_uniprotkb": "KCNJ2; IRK1", "gene_names_refseq": "IRK1; KCNJ2; Kir2.1", "protein_names_uniprotkb": "Inward rectifier potassium channel 2; IRK-1; Inward rectifier K(+) channel Kir2.1; Potassium channel, inwardly rectifying subfamily J member 2", "protein_names_refseq": "IRK-1; inward rectifier K(+) channel Kir2.1; inward rectifier potassium channel 2; inward rectifier potassium channel cIRK1; potassium channel, inwardly rectifying subfamily J member 2", "tax_id": 9031, "disease": "", "pathway": " (gga:396328)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "26520451;7642595;9533862", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX933572.2, U20216.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000317.1. On Sep 23, 2021 this sequence version replaced NP_990701.1., [RefSeq]; Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (PubMed:7642595, PubMed:9533862). Can be blocked by external barium (PubMed:7642595). Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Molecular dynamics simulations were performed to investigate the structural mechanism of chicken Kir2.2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O42229", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030315 T-tubule;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006813 potassium ion transport;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P52186-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52731-1", "uniprot_id": [ { "id": "PDE6C_CHICK", "url": "https://www.uniprot.org/uniprot/P52731", "type": "external" } ], "mass": 100009.0, "length": 862, "protein_name": "Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'", "gene_name": "PDE6C", "organism": "Chicken", "refseq_name": "cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'", "refseq_ac": [ { "id": "NP_990317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990317", "type": "external" } ], "gene_names_uniprotkb": "PDE6C", "gene_names_refseq": "PDE6C", "protein_names_uniprotkb": "Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; 3.1.4.35; cGMP phosphodiesterase 6C", "protein_names_refseq": "cGMP phosphodiesterase 6C; cone cGMP phosphodiesterase a'-subunit; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'; phosphodiesterase 6C, cGMP-specific, cone, alpha prime", "tax_id": 9031, "disease": "", "pathway": " (gga:395834)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18614542;7821382", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L29233.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992393 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L29233.1., [RefSeq]; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P52731-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52802-1", "uniprot_id": [ { "id": "EFNA2_CHICK", "url": "https://www.uniprot.org/uniprot/P52802", "type": "external" } ], "mass": 23049.0, "length": 200, "protein_name": "Ephrin-A2", "gene_name": "EFNA2", "organism": "Chicken", "refseq_name": "ephrin-A2 precursor", "refseq_ac": [ { "id": "NP_990314", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990314", "type": "external" } ], "gene_names_uniprotkb": "EFNA2; ELF1; EPLG6; LERK6", "gene_names_refseq": "EFNA2; ELF-1", "protein_names_uniprotkb": "Ephrin-A2; ELF-1; EPH-related receptor tyrosine kinase ligand 6; LERK-6", "protein_names_refseq": "EPH-related receptor tyrosine kinase ligand 6; Eph ligand family-1; LERK-6; ephrin-A2 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:395831)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7634327", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: L40932.1, BU237157.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L40932.1., [RefSeq]; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0048013 ephrin receptor signaling pathway;GO:0046849 bone remodeling;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P52802-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52804-1", "uniprot_id": [ { "id": "EFNA5_CHICK", "url": "https://www.uniprot.org/uniprot/P52804", "type": "external" } ], "mass": 26206.0, "length": 228, "protein_name": "Ephrin-A5", "gene_name": "EFNA5", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EFNA5; RAGS", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephrin-A5; EPH-related receptor tyrosine kinase ligand 7; LERK-7; Repulsive axon guidance signal protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396100)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7634326", "class_list": "", "function": "Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation (By similarity). Induces growth cone collapse and repulsion of retinal ganglion cell axons., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding;GO:0045499 chemorepellent activity;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0051893 regulation of focal adhesion assembly;GO:0032956 regulation of actin cytoskeleton organization;GO:0048013 ephrin receptor signaling pathway;GO:0022407 regulation of cell-cell adhesion;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P52804-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53449-1", "uniprot_id": [ { "id": "ALDOC_CHICK", "url": "https://www.uniprot.org/uniprot/P53449", "type": "external" } ], "mass": 14438.0, "length": 137, "protein_name": "Fructose-bisphosphate aldolase C", "gene_name": "ALDOC", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ALDOC", "gene_names_refseq": "", "protein_names_uniprotkb": "Fructose-bisphosphate aldolase C; 4.1.2.13; Brain-type aldolase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-352875); (R-GGA-352882)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "1593633;16287166;2110163;2985560;3094011;3539098;3885220;4463937;499525;6303388;6345546;6574503;7629021;7768978;7916593;8182283;9434147", "class_list": "", "function": "Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" } ], "go_molecular_function": "GO:0004332 fructose-bisphosphate aldolase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0030388 fructose 1,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "P53449-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53760-1", "uniprot_id": [ { "id": "LCAT_CHICK", "url": "https://www.uniprot.org/uniprot/P53760", "type": "external" } ], "mass": 47804.0, "length": 413, "protein_name": "Phosphatidylcholine-sterol acyltransferase", "gene_name": "LCAT", "organism": "Chicken", "refseq_name": "phosphatidylcholine-sterol acyltransferase precursor", "refseq_ac": [ { "id": "NP_001280023", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280023", "type": "external" } ], "gene_names_uniprotkb": "LCAT", "gene_names_refseq": "LCAT", "protein_names_uniprotkb": "Phosphatidylcholine-sterol acyltransferase; 2.3.1.43; Lecithin-cholesterol acyltransferase; Phospholipid-cholesterol acyltransferase", "protein_names_refseq": "phosphatidylcholine-sterol acyltransferase precursor; phosphatidylcholine-sterol acyltransferase; phospholipid-cholesterol acyltransferase", "tax_id": 9031, "disease": "", "pathway": " (gga:396136)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7592817;8820107", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X91011.1, HAEK01013473.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000247.1. On May 29, 2014 this sequence version replaced XP_414027.4., [RefSeq]; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:8820107)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.43", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.43", "type": "external" } ], "go_molecular_function": "GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0008203 cholesterol metabolic process;GO:0046470 phosphatidylcholine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P53760-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55024-1", "uniprot_id": [ { "id": "TYRO_CHICK", "url": "https://www.uniprot.org/uniprot/P55024", "type": "external" } ], "mass": 60357.0, "length": 529, "protein_name": "Tyrosinase", "gene_name": "TYR", "organism": "Chicken", "refseq_name": "tyrosinase precursor", "refseq_ac": [ { "id": "NP_989491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989491", "type": "external" } ], "gene_names_uniprotkb": "TYR", "gene_names_refseq": "TYR", "protein_names_uniprotkb": "Tyrosinase; 1.14.18.1; Monophenol monooxygenase", "protein_names_refseq": "monophenol monooxygenase; tyrosinase TYR-AS1; tyrosinase TYR-AS2; tyrosinase TYR-AS3; tyrosinase TYR-AS4; tyrosinase TYR-AS5; tyrosinase precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:373971)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1494538;19437131;20460655;29050424;30293452;8647445", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D88349.1, S81675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02738221 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000027.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Among the 11 chicken tissues examined, the feather bulb, comb and skin showed higher levels of all TYR variants. All TYR variants were expressed at significantly different levels in black and white feather bulbs and may be involved in melanin formation in plumage., [RefSeq, PubMed]; Individuals with genotypes AA and AT had greater TYR expression than those with genotype TT. A luciferase assay of the promoter activity revealed that genotype AA had greater activity than genotype TT., [RefSeq, PubMed]; The co-segregation of plumage coloration and sequence polymorphism in TYR and MC1R genes were investigated using an intercross between black and white plumage color types of the Dongxiang blue-shelled chicken., [RefSeq, PubMed]; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds (By similarity). Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine (By similarity). In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone (By similarity)., [UniProtKB, UniProtKB]; This study provided original information for elucidating the possible roles of exon-1 of TYR gene and 5' flanking region in chickens with different flesh color chicken., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0004503 tyrosinase activity", "go_cellular_component": "GO:0042470 melanosome;GO:0033162 melanosome membrane", "go_biological_process": "GO:0043473 pigmentation;GO:0042438 melanin biosynthetic process;GO:0009637 response to blue light", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P55024-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55169-1", "uniprot_id": [ { "id": "CCND1_CHICK", "url": "https://www.uniprot.org/uniprot/P55169", "type": "external" } ], "mass": 33264.0, "length": 292, "protein_name": "G1/S-specific cyclin-D1", "gene_name": "CCND1", "organism": "Chicken", "refseq_name": "G1/S-specific cyclin-D1 isoform 1", "refseq_ac": [ { "id": "NP_990712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990712", "type": "external" } ], "gene_names_uniprotkb": "CCND1", "gene_names_refseq": "CCND1", "protein_names_uniprotkb": "G1/S-specific cyclin-D1", "protein_names_refseq": "G1/S-specific cyclin-D1 isoform 1; G1/S-specific cyclin-D1; cyclin D1 (PRAD1: parathyroid adenomatosis 1)", "tax_id": 9031, "disease": "", "pathway": " (gga:396341)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15328007;18678914;21709239;23193186", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267652.7887.1, SRR13267658.24485.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1. On Oct 19, 2021 this sequence version replaced NP_990712.1., [RefSeq]; FGF signaling maintains cyclin D2 in the immature caudal neural epithelium, while Shh activates cyclin D1 in the neural groove., [RefSeq, PubMed]; Motoneuron progenitors in the embryonic spinal cord persistently express Cyclin D1 during the initial phase of differentiation, while down-regulating Cyclin D2, [RefSeq, PubMed]; Pitx2 activity directs asymmetrical gonad morphogenesis by controlling mitotic spindle orientation of the developing gonad cortex and how, by modulating cyclinD1 expression during asymmetric ovarian development, [RefSeq, PubMed]; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals., [UniProtKB, UniProtKB]; The cell cycle inhibitor p21 was significantly increased, whereas cyclin D1, a cell cycle promoter, decreased in sustained hyperglycemia compared with controls, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0043539 protein serine/threonine kinase activator activity;GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex;GO:0005815 microtubule organizing center;GO:0000307 cyclin-dependent protein kinase holoenzyme complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010971 positive regulation of G2/M transition of mitotic cell cycle;GO:0051301 cell division;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55169-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55806-1", "uniprot_id": [ { "id": "NRT1_CHICK", "url": "https://www.uniprot.org/uniprot/P55806", "type": "external" } ], "mass": 35319.0, "length": 312, "protein_name": "NAD(P)(+)--arginine ADP-ribosyltransferase 1", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "NAD(P)(+)--arginine ADP-ribosyltransferase 1; 2.4.2.31; AT1; Mono(ADP-ribosyl)transferase 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7961658", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.31", "type": "external" } ], "go_molecular_function": "GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:0106274 NAD+-protein-arginine ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0044194 cytolytic granule", "go_biological_process": "GO:0046677 response to antibiotic", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P55806-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55878-1", "uniprot_id": [ { "id": "GLI1_CHICK", "url": "https://www.uniprot.org/uniprot/P55878", "type": "external" } ], "mass": 60216.0, "length": 556, "protein_name": "Transcription activator GLI1", "gene_name": "GLI1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GLI1; GLI", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription activator GLI1; GLI", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8948590", "class_list": "", "function": "Transcription activator that acts as a key effector of the smoothened signaling pathway, and which plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract (PubMed:8948590). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (By similarity). Activated in response to smoothened signaling: in presence of hedgehog (DHH, IHH or SHH) and subsequent activation of smoothened, GLI1 translocates to the nucleus and promotes expression of target genes (By similarity). In contrast to GLI2 and GLI3, does not contain a repressor domain and only acts as a transcription activator (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P55878-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56734-1", "uniprot_id": [ { "id": "AVR4_CHICK", "url": "https://www.uniprot.org/uniprot/P56734", "type": "external" } ], "mass": 16644.0, "length": 150, "protein_name": "Avidin-related protein 4/5", "gene_name": "AVR4; AVR5", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AVR4; AVR5", "gene_names_refseq": "", "protein_names_uniprotkb": "Avidin-related protein 4/5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "11964162;15858262;8125122", "class_list": "", "function": "Forms a strong non-covalent specific complex with biotin., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0009374 biotin binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P56734-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P59101-1", "uniprot_id": [ { "id": "SCX_CHICK", "url": "https://www.uniprot.org/uniprot/P59101", "type": "external" } ], "mass": 20562.0, "length": 187, "protein_name": "Basic helix-loop-helix transcription factor scleraxis", "gene_name": "SCX", "organism": "Chicken", "refseq_name": "basic helix-loop-helix transcription factor scleraxis", "refseq_ac": [ { "id": "NP_989584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989584", "type": "external" } ], "gene_names_uniprotkb": "SCX", "gene_names_refseq": "SCXB; SCX", "protein_names_uniprotkb": "Basic helix-loop-helix transcription factor scleraxis", "protein_names_refseq": "basic helix-loop-helix transcription factor scleraxis; class II bHLH protein scleraxis; scleraxis homolog B", "tax_id": 9031, "disease": "", "pathway": " (gga:374101)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "11585810;15253939;15716340;16876153;19717568;26662056;29330921;31024001;32930359", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF505881.1, BU324587.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000050.1 and JAENSK010000049.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Gain-of-function and loss-of-function experiments in the micromass culture assay revealed a positive transcriptional influence of Fhl2 in the expression of Scleraxis., [RefSeq, PubMed]; Increased or decreased levels of phosphorylated ERK result in the loss of scleraxis transcripts, distal rib development, [RefSeq, PubMed]; Inhibition of WNT/beta-catenin is necessary and sufficient to induce Scx expression in developing tendons of chicken limb., [RefSeq, PubMed]; Overexpression of Btg1 induced intense upregulation of Scleraxis. In complementary knockdown experiments, this marker was regulated in an opposite fashion., [RefSeq, PubMed]; Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages., [UniProtKB]; TGF B treatments upregulate Scleraxis preceding both fibrogenesis in the micromass cultures and cartilage differentiation during interdigital ectopic chondrogenesis., [RefSeq, PubMed]; The increased chondrogenesis observed in loss-of-function experiments of Uhrfs genes in micromass cultures was preceded by downregulation of Scleraxis gene. Publication Status: Online-Only, [RefSeq, PubMed]; These findings suggest that TeM is a late marker of tendon formation and that Scx positively regulates TeM expression in a tendon cell lineage-dependent manner., [RefSeq, PubMed]; Transcriptional activation by Pea3 and Erm in response to FGF signaling is both necessary and sufficient for Scx expression., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032502 developmental process;GO:0071773 cellular response to BMP stimulus;GO:0044344 cellular response to fibroblast growth factor stimulus", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P59101-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62985-1", "uniprot_id": [ { "id": "RL40_CHICK", "url": "https://www.uniprot.org/uniprot/P62985", "type": "external" } ], "mass": 8098.0, "length": 69, "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "UBA52; UBCEP2", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eL40 fusion protein; 60S ribosomal protein L40; CEP52; Ubiquitin A-52 residue ribosomal protein fusion product 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1227882); (R-GGA-1227888); (R-GGA-1227892); (R-GGA-351465); (R-GGA-353299); (R-GGA-353303); (R-GGA-433822); (R-GGA-433871); (R-GGA-434001); (R-GGA-434131); (R-GGA-437980); (R-GGA-437986); (R-GGA-573298)", "pathway_count": 13, "publication_count": 63, "publication_id_list": "10893229;11057907;11239454;11460167;12086603;12193592;12221085;12442171;12609980;12692549;12773817;13130464;14555995;14625308;14633987;15145317;15287722;15371334;15572677;15642098;15837794;16056267;16115877;16116421;16153868;16186825;16260493;16301747;16306937;16858409;16914100;17047224;17135271;17255097;17327220;17332413;17395714;17412408;17452773;17460694;17496917;17526488;1764072;17875933;17878161;18070982;18200010;18793328;18984593;19224918;19465916;19479062;19666475;19675569;19881509;19898473;20097753;2850543;8533096;8846784;9195981;9463386;9689078", "class_list": "", "function": "Component of the 60S subunit of the ribosome., [UniProtKB, UniProtKB]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02248;P02249;P02250;P14793;P62973;Q29120;Q91887;Q91888", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 6.4, "record_id": "P62985-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68246-1", "uniprot_id": [ { "id": "TNNI2_CHICK", "url": "https://www.uniprot.org/uniprot/P68246", "type": "external" } ], "mass": 21234.0, "length": 183, "protein_name": "Troponin I, fast skeletal muscle", "gene_name": "TNNI2", "organism": "Chicken", "refseq_name": "troponin I, fast skeletal muscle", "refseq_ac": [ { "id": "NP_990748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990748", "type": "external" } ], "gene_names_uniprotkb": "TNNI2", "gene_names_refseq": "TNI; TNNI2", "protein_names_uniprotkb": "Troponin I, fast skeletal muscle; Troponin I, fast-twitch isoform", "protein_names_refseq": "sTnI protein (aa 85-182); troponin I type 2 (skeletal, fast); troponin I, fast skeletal muscle; troponin I, skeletal, fast", "tax_id": 9031, "disease": "", "pathway": " (gga:396386)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "15784741;16061251;16415057;25752780;3010234;624283;8318890", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01003131.1, HAEK01110633.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04013383 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000214.1., [RefSeq]; Data indicate that myocardial markers ISL1, TNNI2 and NKX2-5 and HCN4 were studied in sequential stages of chick embryo development., [RefSeq, PubMed]; Results describe the solution structures of a 'mobile' actin-binding domain (approximately 6.1 kDa) in the troponin ternary complex., [RefSeq, PubMed]; The C-terminal region of TnI is a tethered domain connected to the rest of the troponin complex by a flexible linker, residues 137-146, followed by a collapsed region with at most nascent secondary structure, [RefSeq, PubMed]; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02644", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005861 troponin complex", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0060048 cardiac muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P68246-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70079-1", "uniprot_id": [ { "id": "KCRU_CHICK", "url": "https://www.uniprot.org/uniprot/P70079", "type": "external" } ], "mass": 47104.0, "length": 417, "protein_name": "Creatine kinase U-type, mitochondrial", "gene_name": "CKMT1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CKMT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Creatine kinase U-type, mitochondrial; 2.7.3.2; Acidic-type mitochondrial creatine kinase; Mia-CK; U-MtCK; Ubiquitous mitochondrial creatine kinase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2831887;8662608", "class_list": "", "function": "Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90782", "ec_number_list": [ { "id": "2.7.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.3.2", "type": "external" } ], "go_molecular_function": "GO:0004111 creatine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0046314 phosphocreatine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P70079-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P70081-1", "uniprot_id": [ { "id": "H48_CHICK", "url": "https://www.uniprot.org/uniprot/P70081", "type": "external" } ], "mass": 11439.0, "length": 103, "protein_name": "Histone H4 type VIII", "gene_name": "H4-VIII", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "H4-VIII", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H4 type VIII", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8804862", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006334 nucleosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P70081-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79760-1", "uniprot_id": [ { "id": "CP1A4_CHICK", "url": "https://www.uniprot.org/uniprot/P79760", "type": "external" } ], "mass": 59361.0, "length": 530, "protein_name": "Cytochrome P450 1A4", "gene_name": "CYP1A4", "organism": "Chicken", "refseq_name": "cytochrome P450 1A4", "refseq_ac": [ { "id": "NP_990478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990478", "type": "external" } ], "gene_names_uniprotkb": "CYP1A4", "gene_names_refseq": "CYP1A1; CYP1A4; CYP1A5; CYPIA4; CYPIA5", "protein_names_uniprotkb": "Cytochrome P450 1A4; 1.14.14.1; CYPIA4; Cytochrome P450 TCDDAHH", "protein_names_refseq": "cytochrome P450 1A1; cytochrome P450 1A4; cytochrome P450 1A5; cytochrome P450 TCDDAA; cytochrome P450 TCDDAHH; cytochrome P450, family 1, subfamily A, polypeptide 4", "tax_id": 9031, "disease": "", "pathway": " (gga:396052)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "23726999;28364347;8955152", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X99453.1, SRR13267659.295037.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000245.1. On Oct 1, 2021 this sequence version replaced NP_990478.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; CYP1A4 and CYP1A5 have different and somewhat overlapping substrate specificity in quinoxaline metabolism, [RefSeq, PubMed]; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics., [UniProtKB]; The metabolism of xenobiotics by cytochrome P450 was significantly different during the process of male germ cell differentiation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.14.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.-", "type": "external" }, { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen;GO:0008395 steroid hydroxylase activity;GO:0004497 monooxygenase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0043231 intracellular membrane-bounded organelle;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008210 estrogen metabolic process;GO:0006805 xenobiotic metabolic process;GO:0046677 response to antibiotic;GO:0042178 xenobiotic catabolic process;GO:0009404 toxin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P79760-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79763-1", "uniprot_id": [ { "id": "FSHR_CHICK", "url": "https://www.uniprot.org/uniprot/P79763", "type": "external" } ], "mass": 78698.0, "length": 693, "protein_name": "Follicle-stimulating hormone receptor", "gene_name": "FSHR", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FSHR", "gene_names_refseq": "", "protein_names_uniprotkb": "Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395962)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8902217;9332357", "class_list": "", "function": "G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q90719", "ec_number_list": [], "go_molecular_function": "GO:0004963 follicle-stimulating hormone receptor activity;GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0008584 male gonad development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P79763-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79784-1", "uniprot_id": [ { "id": "ENTP2_CHICK", "url": "https://www.uniprot.org/uniprot/P79784", "type": "external" } ], "mass": 54534.0, "length": 495, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 2", "gene_name": "ENTPD2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENTPD2; CD39L1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 2; 3.6.1.5; CD39 antigen-like 1; Ecto-ATP diphosphohydrolase 2; Ecto-ATPDase 2; Ecto-ATPase 2; NTPDase 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "7989647;8995405", "class_list": "", "function": "Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs), with a marked preference for triphosphonucleosides over diphosphonucleosides. The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates. This activity contributes to the regulation of extracellular nucleotides levels (By similarity). ATP hydrolysis is characterized by fast ADP accumulation and delayed AMP formation, reflecting limited ADP hydrolase activity (By similarity). Hydrolyzes ADP and UDP only to a marginal extent, and does not hydrolyze AMP (By similarity). All nucleoside 5'-diphosphates are hydrolyzed at rates lower than those of their corresponding triphosphates (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0016887 ATP hydrolysis activity;GO:0004382 GDP phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0009203 ribonucleoside triphosphate catabolic process;GO:0009134 nucleoside diphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P79784-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79785-1", "uniprot_id": [ { "id": "AGTR1_CHICK", "url": "https://www.uniprot.org/uniprot/P79785", "type": "external" } ], "mass": 41220.0, "length": 359, "protein_name": "Type-1 angiotensin II receptor", "gene_name": "AGTR1", "organism": "Chicken", "refseq_name": "type-1 angiotensin II receptor", "refseq_ac": [ { "id": "NP_990488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990488", "type": "external" } ], "gene_names_uniprotkb": "AGTR1", "gene_names_refseq": "AGTR1", "protein_names_uniprotkb": "Type-1 angiotensin II receptor; AT1 receptor; Angiotensin II type-1 receptor", "protein_names_refseq": "AT1 receptor; AT1; angiotensin II type-1 receptor; type-1 angiotensin II receptor", "tax_id": 9031, "disease": "", "pathway": " (gga:396065); (R-GGA-375276); (R-GGA-416476); (R-GGA-8856825); (R-GGA-8856828)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "20495810;28339549;8985144", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BI064791.1, SRR12888487.172186.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992432, SAMEA103992437 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1., [RefSeq]; In contrast to the authors' previous genome wide association study and microsatellite data, they find no association of the SNP genotypes or haplotypes in the region between 11.8 and 13.6 Mbp on chromosome 9, suggesting that the AGTR1 and UTS2D genes might have limited association with the disease phenotype., [RefSeq, PubMed]; Investigation of gene expression and role of Ang II receptor during embryonic development: expression in CAM and heart of embryo; limited effect of Ang II receptor antagonist on blood pressure of embryo, [RefSeq, PubMed]; Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031711 bradykinin receptor binding;GO:0001596 angiotensin type I receptor activity;GO:0004945 angiotensin type II receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0001822 kidney development;GO:0008217 regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P79785-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79880-1", "uniprot_id": [ { "id": "GUC1A_CHICK", "url": "https://www.uniprot.org/uniprot/P79880", "type": "external" } ], "mass": 22808.0, "length": 199, "protein_name": "Guanylyl cyclase-activating protein 1", "gene_name": "GUCA1A", "organism": "Chicken", "refseq_name": "guanylyl cyclase-activating protein 1", "refseq_ac": [ { "id": "NP_989651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989651", "type": "external" } ], "gene_names_uniprotkb": "GUCA1A; GCAP1", "gene_names_refseq": "GCAP1; GUCA1A", "protein_names_uniprotkb": "Guanylyl cyclase-activating protein 1; GCAP 1; Guanylate cyclase activator 1A", "protein_names_refseq": "GCAP 1; guanylate cyclase activator 1A (retina); guanylyl cyclase-activating protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:374216); (R-GGA-2514859)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10427104;17997965;8641465", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DR427576.1, DR424159.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000356.1., [RefSeq]; Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030249 guanylate cyclase regulator activity;GO:0008048 calcium sensitive guanylate cyclase activator activity", "go_cellular_component": "GO:0001917 photoreceptor inner segment;GO:0120199 cone photoreceptor outer segment", "go_biological_process": "GO:0031284 positive regulation of guanylate cyclase activity;GO:0071277 cellular response to calcium ion;GO:0007601 visual perception;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P79880-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79995-1", "uniprot_id": [ { "id": "CAD10_CHICK", "url": "https://www.uniprot.org/uniprot/P79995", "type": "external" } ], "mass": 88392.0, "length": 789, "protein_name": "Cadherin-10", "gene_name": "CDH10", "organism": "Chicken", "refseq_name": "cadherin-10 precursor", "refseq_ac": [ { "id": "NP_999838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_999838", "type": "external" } ], "gene_names_uniprotkb": "CDH10", "gene_names_refseq": "CDH10; cadherin-10", "protein_names_uniprotkb": "Cadherin-10", "protein_names_refseq": "cadherin 10, type 2 (T2-cadherin); cadherin-10 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:408049); (R-GGA-418990)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "9215642", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB000512.1, SRR13267649.125720.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB000512.1. On Aug 30, 2004 this sequence version replaced XP_444653.1., [RefSeq]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P79995-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80226-1", "uniprot_id": [ { "id": "FABPL_CHICK", "url": "https://www.uniprot.org/uniprot/P80226", "type": "external" } ], "mass": 14210.0, "length": 126, "protein_name": "Fatty acid-binding protein, liver", "gene_name": "FABP1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FABP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Fatty acid-binding protein, liver; Fatty acid-binding protein 1; L-BABP; L-FABP; LB-FABP; Liver basic FABP; Liver bile acid-binding protein; Liver-type fatty acid-binding protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395345)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12652125;15518556;16439356;2266974;7553344", "class_list": "", "function": "Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Binds 2 molecules of cholate per subunit., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90WB0", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P80226-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80585-1", "uniprot_id": [ { "id": "TBCA_CHICK", "url": "https://www.uniprot.org/uniprot/P80585", "type": "external" } ], "mass": 12679.0, "length": 108, "protein_name": "Tubulin-specific chaperone A", "gene_name": "TBCA", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TBCA", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubulin-specific chaperone A; CFA; TCP1-chaperonin cofactor A; Tubulin-folding cofactor A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8756698", "class_list": "", "function": "Tubulin-folding protein; involved in the early step of the tubulin folding pathway., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005874 microtubule;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006457 protein folding;GO:0007021 tubulin complex assembly;GO:0007023 post-chaperonin tubulin folding pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P80585-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q00546-1", "uniprot_id": [ { "id": "TENR_CHICK", "url": "https://www.uniprot.org/uniprot/Q00546", "type": "external" } ], "mass": 148280.0, "length": 1353, "protein_name": "Tenascin-R", "gene_name": "TNR", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TNR", "gene_names_refseq": "", "protein_names_uniprotkb": "Tenascin-R; Restrictin; TN-R", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396213)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "11069908;1375037;7615642;9049254;9722619", "class_list": "", "function": "Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Involved in cell attachment and neurite formation. Interaction with CNTN1 enhances the neurite outgrowth., [UniProtKB, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q00546-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02011-1", "uniprot_id": [ { "id": "CNTF_CHICK", "url": "https://www.uniprot.org/uniprot/Q02011", "type": "external" } ], "mass": 21330.0, "length": 195, "protein_name": "Ciliary neurotrophic factor", "gene_name": "CNTF", "organism": "Chicken", "refseq_name": "ciliary neurotrophic factor", "refseq_ac": [ { "id": "NP_990823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990823", "type": "external" } ], "gene_names_uniprotkb": "CNTF; CNF; GPA", "gene_names_refseq": "CNF; CNTF; GPA", "protein_names_uniprotkb": "Ciliary neurotrophic factor; CNTF; GPA; Growth-promoting activity", "protein_names_refseq": "ciliary neurotrophic factor; growth-promoting activity factor", "tax_id": 9031, "disease": "", "pathway": " (gga:396488); (R-GGA-6788467)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "1610564;2322465", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: M80827.1, SRR13267657.28204.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M80827.1., [RefSeq]; Functions as a cytokine through the ciliary neurotrophic factor receptor (CNTFR) complex. The CNTFR complex indeed consists of the membrane-anchored non-signaling receptor CNTFR and the two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (By similarity). Functionally, promotes neuronal survival, supports differentiation of various neuronal and non-neuronal cells, and importantly regulates oligodendrocyte progenitor proliferation (PubMed:2322465). Mechanistically, ligand binding to the CNTFR induces dimerization of the IL6ST/gp130 and LIFR, which activates JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains, which activate JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1). Can also signal via trans-signaling using soluble forms of CNTFR (By similarity). Seems to prevent the degeneration of motor axons after axotomy (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005138 interleukin-6 receptor binding;GO:0005127 ciliary neurotrophic factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030424 axon;GO:0043025 neuronal cell body;GO:0032991 protein-containing complex", "go_biological_process": "GO:0048680 positive regulation of axon regeneration;GO:0070120 ciliary neurotrophic factor-mediated signaling pathway;GO:0070446 negative regulation of oligodendrocyte progenitor proliferation;GO:0048143 astrocyte activation;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q02011-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02960-1", "uniprot_id": [ { "id": "MIF_CHICK", "url": "https://www.uniprot.org/uniprot/Q02960", "type": "external" } ], "mass": 12484.0, "length": 115, "protein_name": "Macrophage migration inhibitory factor", "gene_name": "MIF", "organism": "Chicken", "refseq_name": "macrophage migration inhibitory factor", "refseq_ac": [ { "id": "NP_001292020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292020", "type": "external" } ], "gene_names_uniprotkb": "MIF", "gene_names_refseq": "MIF", "protein_names_uniprotkb": "Macrophage migration inhibitory factor; 5.3.2.1; 5.3.3.12; L-dopachrome isomerase; L-dopachrome tautomerase; MIF; Phenylpyruvate tautomerase", "protein_names_refseq": "L-dopachrome isomerase; L-dopachrome tautomerase; Phenylpyruvate tautomerase; macrophage migration inhibitory factor (glycosylation-inhibiting factor); macrophage migration inhibitory factor", "tax_id": 9031, "disease": "", "pathway": " (gga:100857237)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "25086294;7679497", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DR425057.1, CF250536.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BU431911.1, AB052158.1 and AL585053.1. On Feb 21, 2015 this sequence version replaced XP_003642282.1. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; Both host and parasite MIF molecules bind to chicken macrophages via CD74 surface receptor., [RefSeq, PubMed]; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" } ], "go_molecular_function": "GO:0005125 cytokine activity;GO:0042289 MHC class II protein binding;GO:0004167 dopachrome isomerase activity;GO:0050178 phenylpyruvate tautomerase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q02960-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03696-1", "uniprot_id": [ { "id": "NGCA_CHICK", "url": "https://www.uniprot.org/uniprot/Q03696", "type": "external" } ], "mass": 136571.0, "length": 1266, "protein_name": "Neuronal-glial cell adhesion molecule", "gene_name": "", "organism": "Chicken", "refseq_name": "neuronal-glial cell adhesion molecule precursor", "refseq_ac": [ { "id": "NP_990484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990484", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "L1CAM", "protein_names_uniprotkb": "Neuronal-glial cell adhesion molecule; Ng-CAM", "protein_names_refseq": "neuron-glia cell adhesion molecule (Ng-CAM); neuronal-glial cell adhesion molecule precursor; neuronal-glial cell adhesion molecule; ng-CAM", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1705558;25308870", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X56969.1 [ECO:0000332] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X56969.1., [RefSeq]; Blocking studies revealed that L1CAM is primarily responsible for these Schwann cell-neurite interactions., [RefSeq, PubMed]; Mediates the adhesion of neurons to neurons and neurons to glia. It is involved in neuronal migration, neurite fasciculation and outgrowth., [UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 12, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0044295 axonal growth cone", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411 axon guidance;GO:0070593 dendrite self-avoidance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q03696-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04594-1", "uniprot_id": [ { "id": "PRLR_CHICK", "url": "https://www.uniprot.org/uniprot/Q04594", "type": "external" } ], "mass": 94102.0, "length": 831, "protein_name": "Prolactin receptor", "gene_name": "PRLR", "organism": "Chicken", "refseq_name": "prolactin receptor precursor", "refseq_ac": [ { "id": "NP_990185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990185", "type": "external" } ], "gene_names_uniprotkb": "PRLR", "gene_names_refseq": "PRL-R; PRLRb; PRLR", "protein_names_uniprotkb": "Prolactin receptor; PRL-R; cPRLR", "protein_names_refseq": "cPRLR; dPRLR-dSPEF2 fusion; equates to base 1078-1204 of D13154; prolactin receptor b; prolactin receptor precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:395660)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1445292;17675186;27081197;29253229;29566646;34998433", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000087.1. On Dec 27, 2021 this sequence version replaced NP_990185.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A comprehensive survey for the presence or absence of ev21 and incomplete duplication (ID) of prolactin receptor (PRLR) and sperm flagellar protein 2 (SPEF2) genes across 1,994 birds from 52 chicken breeds, three commercial hybrid groups, and the Red Jungle Fowl revealed that almost all LF breeds have both ev21 and ID., [RefSeq, PubMed]; DPRLR causes differences in immune responses between early and late feathering chickens after ALV-J infection. Publication Status: Online-Only, [RefSeq, PubMed]; Prlr expression in the skin did not show significant difference between early- (EF) and late-feathering (LF) phenotype chicks, while Spef2 expression displayed a significant difference between EF and LF chicks, suggesting that Spef2 may be a good candidate gene for chicken feathering. Moreover, dPrlr/dSpef2, the fusion gene, was also a good candidate gene as it was expressed only in LF chicks., [RefSeq, PubMed]; Study presents the causal mutation for feathering rate in turkey that causes a partial C-terminal loss of the prolactin receptor, and this truncated PRLR protein is strikingly similar to the protein encoded by the slow feathering K allele in chicken. Publication Status: Online-Only, [RefSeq, PubMed]; This is a receptor for the anterior pituitary hormone prolactin., [UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0017046 peptide hormone binding;GO:0019955 cytokine binding;GO:0004925 prolactin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q04594-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07497-1", "uniprot_id": [ { "id": "EPHB5_CHICK", "url": "https://www.uniprot.org/uniprot/Q07497", "type": "external" } ], "mass": 111947.0, "length": 1002, "protein_name": "Ephrin type-B receptor 5", "gene_name": "EPHB5", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EPHB5; CEK9", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephrin type-B receptor 5; 2.7.10.1; EK9; EPH-like kinase 9; cEK9", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:418308)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8510926;8909550", "class_list": "", "function": "Receptor for members of the ephrin-B family., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q07497-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09121-1", "uniprot_id": [ { "id": "IF5A1_CHICK", "url": "https://www.uniprot.org/uniprot/Q09121", "type": "external" } ], "mass": 15889.0, "length": 144, "protein_name": "Eukaryotic translation initiation factor 5A-1", "gene_name": "EIF5A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EIF5A1; RCJMB04_6a12", "gene_names_refseq": "", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 5A-1; Eukaryotic initiation factor 5A isoform 1; eIF-4D; eIF-5A-1; eIF-5A1; eIF-5A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1556119;15642098", "class_list": "", "function": "Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZLI6", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q09121-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1HGK7-1", "uniprot_id": [ { "id": "KTNA1_CHICK", "url": "https://www.uniprot.org/uniprot/Q1HGK7", "type": "external" } ], "mass": 56039.0, "length": 492, "protein_name": "Katanin p60 ATPase-containing subunit A1", "gene_name": "KATNA1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KATNA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Katanin p60 ATPase-containing subunit A1; 5.6.1.1; Katanin p60 subunit A1; p60 katanin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:421626)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008568 microtubule severing ATPase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0051013 microtubule severing;GO:0051301 cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1HGK7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1XI86-1", "uniprot_id": [ { "id": "IMPG2_CHICK", "url": "https://www.uniprot.org/uniprot/Q1XI86", "type": "external" } ], "mass": 157540.0, "length": 1423, "protein_name": "Interphotoreceptor matrix proteoglycan 2", "gene_name": "IMPG2", "organism": "Chicken", "refseq_name": "interphotoreceptor matrix proteoglycan 2 precursor", "refseq_ac": [ { "id": "NP_001038104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038104", "type": "external" } ], "gene_names_uniprotkb": "IMPG2", "gene_names_refseq": "IMPG2", "protein_names_uniprotkb": "Interphotoreceptor matrix proteoglycan 2; Sialoprotein associated with cones and rods proteoglycan; Spacrcan", "protein_names_refseq": "interphotoreceptor matrix proteoglycan 2 precursor; sialoprotein associated with cones and rods proteoglycan; spacrcan", "tax_id": 9031, "disease": "", "pathway": " (gga:418393)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16469746", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB204591.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05341171 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000019.1, AB204591.1 and HAEK01027402.1. On Nov 24, 2021 this sequence version replaced NP_001038104.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix., [UniProtKB, UniProtKB]; Cloning and characterization of chick SPACRCAN, [RefSeq, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 7, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0033165 interphotoreceptor matrix", "go_biological_process": "GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1XI86-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q25BN1-1", "uniprot_id": [ { "id": "DICER_CHICK", "url": "https://www.uniprot.org/uniprot/Q25BN1", "type": "external" } ], "mass": 218610.0, "length": 1921, "protein_name": "Endoribonuclease Dicer", "gene_name": "DICER1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DICER1; DICER", "gene_names_refseq": "", "protein_names_uniprotkb": "Endoribonuclease Dicer; 3.1.26.3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:423437)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15247924", "class_list": "", "function": "Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004386 helicase activity;GO:0004525 ribonuclease III activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016442 RISC complex;GO:0070578 RISC-loading complex", "go_biological_process": "GO:0031054 pre-miRNA processing;GO:0030422 siRNA processing;GO:0006309 apoptotic DNA fragmentation;GO:0051239 regulation of multicellular organismal process;GO:0098795 global gene silencing by mRNA cleavage", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q25BN1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2IAL7-1", "uniprot_id": [ { "id": "CTHL2_CHICK", "url": "https://www.uniprot.org/uniprot/Q2IAL7", "type": "external" } ], "mass": 16975.0, "length": 154, "protein_name": "Cathelicidin-2", "gene_name": "CATHL2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CATHL2; CMAP27", "gene_names_refseq": "", "protein_names_uniprotkb": "Cathelicidin-2; CATH-2; Fowlicidin-2; Myeloid antimicrobial peptide 27", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:420407); (R-GGA-6798695); (R-GGA-6803157)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "15963828;16326712", "class_list": "", "function": "Binds bacterial lipopolysaccharide (LPS). Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). Has hemolytic activity (in vitro). May play a role in the innate immune response., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q56QZ4", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0042116 macrophage activation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2IAL7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2LK54-1", "uniprot_id": [ { "id": "COL12_CHICK", "url": "https://www.uniprot.org/uniprot/Q2LK54", "type": "external" } ], "mass": 81837.0, "length": 742, "protein_name": "Collectin-12", "gene_name": "COLEC12", "organism": "Chicken", "refseq_name": "collectin-12", "refseq_ac": [ { "id": "NP_001034688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034688", "type": "external" } ], "gene_names_uniprotkb": "COLEC12; CL3", "gene_names_refseq": "COLEC12", "protein_names_uniprotkb": "Collectin-12; CL-3; Collectin-3; cCL-3", "protein_names_refseq": "cCL-3; collectin 1 precursor CL-3; collectin sub-family member 12; collectin-12; collectin-3", "tax_id": 9031, "disease": "", "pathway": " (gga:421061)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16289291;25721364;36692868", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ157755.1, SRR13267659.121289.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000043.1. On Sep 23, 2021 this sequence version replaced NP_001034688.1., [RefSeq]; Colec12 and Trail signaling confine cranial neural crest cell trajectories and promote collective cell migration., [RefSeq, PubMed]; In chickens, six different collagenous lectins have been characterized so far: mannose-binding lectin (MBL), surfactant protein A (SP-A), collectin 10 (COLEC10), collectin 11 (COLEC11), collectin 12 (COLEC12), lung lectin (LL) and one ficolin (FCN)., [RefSeq, PubMed]; Scavenger receptor that displays several functions associated with host defense. Binds to carbohydrates (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0030169 low-density lipoprotein particle binding;GO:0038187 pattern recognition receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006955 immune response;GO:0030198 extracellular matrix organization;GO:0006910 phagocytosis, recognition", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2LK54-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2LK94-1", "uniprot_id": [ { "id": "COL11_CHICK", "url": "https://www.uniprot.org/uniprot/Q2LK94", "type": "external" } ], "mass": 29503.0, "length": 271, "protein_name": "Collectin-11", "gene_name": "COLEC11", "organism": "Chicken", "refseq_name": "collectin-11 precursor", "refseq_ac": [ { "id": "NP_001038130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038130", "type": "external" } ], "gene_names_uniprotkb": "COLEC11; CL2", "gene_names_refseq": "COLEC11", "protein_names_uniprotkb": "Collectin-11; CL-2; Collectin-2; cCL-2", "protein_names_refseq": "CL-2; cCL-2; collectin 2; collectin sub-family member 11; collectin-11 precursor; collectin-11", "tax_id": 9031, "disease": "", "pathway": " (gga:428649)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16289291;25721364", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ129669.1, SRR13267656.26672.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ129669.1. On Aug 29, 2006 this sequence version replaced XP_426207.1., [RefSeq]; In chickens, six different collagenous lectins have been characterized so far: mannose-binding lectin (MBL), surfactant protein A (SP-A), collectin 10 (COLEC10), collectin 11 (COLEC11), collectin 12 (COLEC12), lung lectin (LL) and one ficolin (FCN)., [RefSeq, PubMed]; Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding. Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0003677 DNA binding;GO:0005509 calcium ion binding;GO:0005537 D-mannose binding;GO:0042806 fucose binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0032502 developmental process;GO:0019730 antimicrobial humoral response;GO:0001867 complement activation, lectin pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2LK94-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YHT7-1", "uniprot_id": [ { "id": "MOR1A_CHICK", "url": "https://www.uniprot.org/uniprot/Q2YHT7", "type": "external" } ], "mass": 33519.0, "length": 300, "protein_name": "Cell surface glycoprotein CD200 receptor 1-A", "gene_name": "CD200R1A", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CD200R1A", "gene_names_refseq": "", "protein_names_uniprotkb": "Cell surface glycoprotein CD200 receptor 1-A; CD200 cell surface glycoprotein receptor 1-A; Cell surface glycoprotein OX2 receptor 1-A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:768673)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18062907", "class_list": "", "function": "", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q2YHT6", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0150077 regulation of neuroinflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2YHT7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q45KJ5-1", "uniprot_id": [ { "id": "LN28A_CHICK", "url": "https://www.uniprot.org/uniprot/Q45KJ5", "type": "external" } ], "mass": 22089.0, "length": 202, "protein_name": "Protein lin-28 homolog A", "gene_name": "LIN28A", "organism": "Chicken", "refseq_name": "protein lin-28 homolog A", "refseq_ac": [ { "id": "NP_001026944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026944", "type": "external" } ], "gene_names_uniprotkb": "LIN28A; LIN28", "gene_names_refseq": "LIN28A; LIN28", "protein_names_uniprotkb": "Protein lin-28 homolog A; Lin-28A", "protein_names_refseq": "Lin-28.1; lin-28A; protein lin-28 homolog A", "tax_id": 9031, "disease": "", "pathway": " (gga:428206)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "18077221;23314866;30520734;37453484", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DQ127226.2, SRR13267648.2373.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA103992290, SAMEA103992531 [ECO:0000350] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ127226.2. On Nov 24, 2005 this sequence version replaced NP_001026944.1., [RefSeq]; Conserved during vertebrate limb development., [RefSeq, PubMed]; Data indicate that cultured embryonic stem cells (cESCs) expressed pluripotency transcription factors, POUV, Sox-2, Nanog and Lin28 exhibited typical characteristics of pluripotency, even after six generations of rapid doubling., [RefSeq, PubMed]; LIN28 is essential for the maintenance of chicken primordial germ cells., [RefSeq, PubMed]; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism. Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (By similarity). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Suppressor of microRNA (miRNA) biogenesis, including that of let-7. Binds specific target miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in their terminal loop, and recruits uridylyltransferase. This results in the terminal uridylation of target pre-miRNAs. Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation (By similarity). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The results show that a regulatory circuit formed by Wnt, Lin28a and let-7 miRNAs controls the deployment and the subsequent silencing of the multipotency program in a position-dependent manner. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0000932 P-body", "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:0019827 stem cell population maintenance;GO:0031054 pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q45KJ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q4KWZ7-1", "uniprot_id": [ { "id": "REV1_CHICK", "url": "https://www.uniprot.org/uniprot/Q4KWZ7", "type": "external" } ], "mass": 138197.0, "length": 1256, "protein_name": "Translesion synthesis protein REV1", "gene_name": "REV1", "organism": "Chicken", "refseq_name": "translesion synthesis protein REV1", "refseq_ac": [ { "id": "NP_001025982", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025982", "type": "external" } ], "gene_names_uniprotkb": "REV1", "gene_names_refseq": "REV1L; REV1", "protein_names_uniprotkb": "Translesion synthesis protein REV1; 2.7.7.-; Molecular adapter protein REV1; REV1 homolog; Rev1-like terminal deoxycytidyl transferase; Reversionless protein 1 homolog; Template-dependent deoxycytidyl transferase REV1", "protein_names_refseq": "DNA repair protein REV1; REV1 homolog; REV1, polymerase (DNA directed); molecular adapter protein REV1; rev1-like terminal deoxycytidyl transferase; reversionless protein 1 homolog; template-dependent deoxycytidyl transferase REV1; translesion synthesis protein REV1", "tax_id": 9031, "disease": "", "pathway": " (gga:418703); (R-GGA-353503)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "12356753;15988022;16263170;25190518", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY675169.1, BU225816.1, BU364855.1, BU262797.1, BU279291.1, BU297371.1 and AJ395921.1. On May 17, 2006 this sequence version replaced NP_001025982.1., [RefSeq]; Bifunctional protein involved in the maintenance of genome stability through translesion DNA synthesis (TLS) and antibody diversification via somatic hypermutation (PubMed:15988022). Functions as a molecular adapter protein at stalled DNA replication, coordinating polymerases recruitment, selection, and switching, in a manner independent of its deoxycytidyl transferase activity. At the site of DNA lesion, recruits and mediates the switch between low-fidelity inserter DNA polymerases, such as POLK, that incorporate nucleotides opposite lesions and the extender DNA polymerase zeta complex which continues DNA synthesis from distorted primer termini. In vitro, acts as a template-dependent deoxycytidyl transferase that preferentially incorporates deoxycytidine residues from dCTP to the 3'-end of a DNA primer opposite apurinic/apyrimidinic (AP) site, uracil, undamaged DNA templates (G > A > C > T) and a variety of damaged DNA templates. Opposite template guanine, efficiently incorporates not only dCMP but also non-complementary dGMP and dTMP, with lower efficiency for dAMP, demonstrating low fidelity on undamaged DNA. This catalytic activity has been implicated in somatic hypermutation, likely achieved by incorporation of deoxycytidine opposite abasic sites, generated at cytidines via activation-induced deoxycytidine deaminase (AID)-mediated deamination and uracil DNA glycosylase (UNG) activity, respectively (By similarity). In addition, exhibits a 5'-deoxyribose-5-phosphate lyase activity in vitro, though its necessity in vivo is not confirmed (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells., [RefSeq, PubMed]; The catalytic activity of REV1 is utilised in vivo in higher eukaryotes and is involved in immunoglobulin diversification., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A0A8V0YTN6", "ec_number_list": [ { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006302 double-strand break repair;GO:0016446 somatic hypermutation of immunoglobulin genes;GO:0019985 translesion synthesis;GO:0042276 error-prone translesion synthesis;GO:0070987 error-free translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q4KWZ7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q56I99-1", "uniprot_id": [ { "id": "SMAD5_CHICK", "url": "https://www.uniprot.org/uniprot/Q56I99", "type": "external" } ], "mass": 52228.0, "length": 465, "protein_name": "SMAD family member 5", "gene_name": "SMAD5", "organism": "Chicken", "refseq_name": "SMAD family member 5", "refseq_ac": [ { "id": "NP_001014968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014968", "type": "external" } ], "gene_names_uniprotkb": "SMAD5; MADH5", "gene_names_refseq": "MADH5; SMAD5", "protein_names_uniprotkb": "SMAD family member 5; MAD homolog 5; Mothers against DPP homolog 5; Mothers against decapentaplegic homolog 5; SMAD 5", "protein_names_refseq": "MAD homolog 5; SMAD 5; SMAD family member 5; SMAD, mothers against DPP homolog 5; mothers against DPP homolog 5; mothers against decapentaplegic homolog 5", "tax_id": 9031, "disease": "", "pathway": " (gga:395679)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15197161;18334652;28219352", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY953144.1, AF143240.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY953144.1. On Apr 21, 2005 this sequence version replaced XP_414623.1., [RefSeq]; Bmp2-mediated Smad5 signalling suppresses the proliferative response to Shh by downregulation of the pathway, and allows granule cell precursor to enter their differentiation programme, [RefSeq, PubMed]; Each digital phalanx-forming region has a unique p-SMAD1/5/8 activity signature, [RefSeq, PubMed]; Our results demonstrated that E8 medium is able to maintain cBC growth for weeks and RA treatment induced germ cell differentiation of cBCs through the BMP-Smad1/5 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070411 I-SMAD binding", "go_cellular_component": "GO:0071144 heteromeric SMAD protein complex;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0030509 BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q56I99-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5EG71-1", "uniprot_id": [ { "id": "EPGN_CHICK", "url": "https://www.uniprot.org/uniprot/Q5EG71", "type": "external" } ], "mass": 17030.0, "length": 151, "protein_name": "Epigen", "gene_name": "EPGN", "organism": "Chicken", "refseq_name": "epigen precursor", "refseq_ac": [ { "id": "NP_001012404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012404", "type": "external" } ], "gene_names_uniprotkb": "EPGN", "gene_names_refseq": "EPGN", "protein_names_uniprotkb": "Epigen; EPG; Epithelial mitogen", "protein_names_refseq": "EPG; epigen precursor; epigen; epithelial mitogen homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:497270); (R-GGA-1257604); (R-GGA-177929); (R-GGA-179812); (R-GGA-180292); (R-GGA-180336); (R-GGA-182971); (R-GGA-212718); (R-GGA-5673001); (R-GGA-6811558); (R-GGA-8856825); (R-GGA-8856828)", "pathway_count": 12, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY885230.1, SRR12888552.142739.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992527 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000073.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Promotes the growth of epithelial cells., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0050679 positive regulation of epithelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5EG71-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F336-1", "uniprot_id": [ { "id": "MBLC2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F336", "type": "external" } ], "mass": 30774.0, "length": 277, "protein_name": "Acyl-coenzyme A thioesterase MBLAC2", "gene_name": "MBLAC2", "organism": "Chicken", "refseq_name": "acyl-coenzyme A thioesterase MBLAC2", "refseq_ac": [ { "id": "NP_001026779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026779", "type": "external" } ], "gene_names_uniprotkb": "MBLAC2; RCJMB04_38d18", "gene_names_refseq": "MBLAC2", "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase MBLAC2; 3.1.2.2; 3.5.2.6; Acyl-CoA thioesterase MBLAC2; Beta-lactamase MBLAC2; Metallo-beta-lactamase domain-containing protein 2; Palmitoyl-coenzyme A thioesterase MBLAC2", "protein_names_refseq": "acyl-CoA thioesterase MBLAC2; acyl-coenzyme A thioesterase MBLAC2; beta-lactamase MBLAC2; metallo-beta-lactamase domain-containing protein 2; palmitoyl-coenzyme A thioesterase MBLAC2", "tax_id": 9031, "disease": "", "pathway": " (gga:431565)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851814.1, SRR13267649.193086.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000095.1. On Aug 8, 2005 this sequence version replaced XP_429119.1., [RefSeq]; Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA). Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.13.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.19", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0052816 long-chain fatty acyl-CoA hydrolase activity;GO:0008800 beta-lactamase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F336-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F352-1", "uniprot_id": [ { "id": "RASN_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F352", "type": "external" } ], "mass": 21278.0, "length": 189, "protein_name": "GTPase NRas", "gene_name": "NRAS", "organism": "Chicken", "refseq_name": "GTPase NRas", "refseq_ac": [ { "id": "NP_001012567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012567", "type": "external" } ], "gene_names_uniprotkb": "NRAS; RCJMB04_34f10", "gene_names_refseq": "N-RAS; NRAS", "protein_names_uniprotkb": "GTPase NRas; 3.6.5.2; Transforming protein N-Ras", "protein_names_refseq": "GTPase NRas; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene-like protein; transforming protein N-Ras", "tax_id": 9031, "disease": "", "pathway": " (gga:419885); (R-GGA-1169092); (R-GGA-1250347); (R-GGA-1433557); (R-GGA-171007); (R-GGA-179812); (R-GGA-180336); (R-GGA-186763); (R-GGA-1963640); (R-GGA-210993); (R-GGA-2179392); (R-GGA-2424491); (R-GGA-2871796); (R-GGA-375165); (R-GGA-5218921); (R-GGA-5621575); (R-GGA-5654688); (R-GGA-5654693); (R-GGA-5654699); (R-GGA-5654700); (R-GGA-5654704); (R-GGA-5654706); (R-GGA-5654712); (R-GGA-5654719); (R-GGA-5658442); (R-GGA-5673000); (R-GGA-5673001); (R-GGA-5674135); (R-GGA-5675221); (R-GGA-6798695); (R-GGA-8849471); (R-GGA-8851805); (R-GGA-9607240); (R-GGA-9634635); (R-GGA-9648002)", "pathway_count": 35, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851798.1, SRR13267655.241638.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000356.1. On Feb 28, 2005 this sequence version replaced XP_418011.1., [RefSeq]; Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (By similarity). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0007265 Ras protein signal transduction;GO:0001938 positive regulation of endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F352-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F362-1", "uniprot_id": [ { "id": "CC50A_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F362", "type": "external" } ], "mass": 41448.0, "length": 372, "protein_name": "Cell cycle control protein 50A", "gene_name": "TMEM30A", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TMEM30A; CDC50A; RCJMB04_32j24", "gene_names_refseq": "", "protein_names_uniprotkb": "Cell cycle control protein 50A; P4-ATPase flippase complex beta subunit TMEM30A; Transmembrane protein 30A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:421861); (R-GGA-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes (By similarity)., [UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015247 aminophospholipid flippase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0045332 phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F362-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F378-1", "uniprot_id": [ { "id": "CTHB1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F378", "type": "external" } ], "mass": 26927.0, "length": 251, "protein_name": "Cathelicidin-B1", "gene_name": "CATHB1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CATHB1; RCJMB04_29o22", "gene_names_refseq": "", "protein_names_uniprotkb": "Cathelicidin-B1; CATH-B1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:100858412)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;17827276", "class_list": "", "function": "Has potent antimicrobial activity against Gram-positive and Gram-negative bacteria (in vitro). May play a role in the innate immune response., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7M6V2", "ec_number_list": [], "go_molecular_function": "GO:0001530 lipopolysaccharide binding", "go_cellular_component": "GO:0099512 supramolecular fiber;GO:0005615 extracellular space", "go_biological_process": "GO:0045087 innate immune response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5F378-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F383-1", "uniprot_id": [ { "id": "SPP2B_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F383", "type": "external" } ], "mass": 66397.0, "length": 596, "protein_name": "Signal peptide peptidase-like 2B", "gene_name": "SPPL2B", "organism": "Chicken", "refseq_name": "signal peptide peptidase-like 2B precursor", "refseq_ac": [ { "id": "NP_001026104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026104", "type": "external" } ], "gene_names_uniprotkb": "SPPL2B; RCJMB04_29c5", "gene_names_refseq": "SPPL2B; SPPL2C", "protein_names_uniprotkb": "Signal peptide peptidase-like 2B; 3.4.23.-; SPP-like 2B; SPPL2b", "protein_names_refseq": "protein SPP-like 2B; protein SPPL2b; signal peptide peptidase like 2B; signal peptide peptidase-like 2B precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:420056)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851767.1, SRR13267654.45117.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000374.1. On Sep 23, 2021 this sequence version replaced NP_001026104.1., [RefSeq]; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0042500 aspartic endopeptidase activity, intramembrane cleaving", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006509 membrane protein ectodomain proteolysis;GO:0050776 regulation of immune response;GO:0031293 membrane protein intracellular domain proteolysis;GO:0033619 membrane protein proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F383-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F3A6-1", "uniprot_id": [ { "id": "OTU1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F3A6", "type": "external" } ], "mass": 33384.0, "length": 302, "protein_name": "Ubiquitin thioesterase OTU1", "gene_name": "YOD1", "organism": "Chicken", "refseq_name": "ubiquitin thioesterase OTU1", "refseq_ac": [ { "id": "NP_001026670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026670", "type": "external" } ], "gene_names_uniprotkb": "YOD1; RCJMB04_24h21", "gene_names_refseq": "YOD1", "protein_names_uniprotkb": "Ubiquitin thioesterase OTU1; 3.4.19.12", "protein_names_refseq": "YOD1 OTU deubiquinating enzyme 1 homolog; ubiquitin thioesterase OTU1", "tax_id": 9031, "disease": "", "pathway": " (gga:428266)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851744.1, SRR13267654.231051.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000356.1. On Aug 8, 2005 this sequence version replaced XP_425825.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Ubiquitin moieties on substrates may present a steric impediment to the threading process when the substrate is transferred to the VCP pore and threaded through VCP's axial channel. Mediates deubiquitination of 'Lys-27'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitin chains. Also able to hydrolyze 'Lys-11'-linked ubiquitin chains. Cleaves both polyubiquitin and di-ubiquitin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070536 protein K63-linked deubiquitination;GO:0016236 macroautophagy;GO:0030968 endoplasmic reticulum unfolded protein response;GO:0036503 ERAD pathway;GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F3A6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F3B1-1", "uniprot_id": [ { "id": "MTG16_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F3B1", "type": "external" } ], "mass": 64874.0, "length": 591, "protein_name": "Transcriptional corepressor CBFA2T3", "gene_name": "CBFA2T3", "organism": "Chicken", "refseq_name": "transcriptional corepressor CBFA2T3", "refseq_ac": [ { "id": "NP_001025751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025751", "type": "external" } ], "gene_names_uniprotkb": "CBFA2T3; RCJMB04_23o9", "gene_names_refseq": "CBFA2T3; MTG16a; MTG16b", "protein_names_uniprotkb": "Transcriptional corepressor CBFA2T3", "protein_names_refseq": "core-binding factor, runt domain, alpha subunit 2; myeloid translocation gene-related protein 2; protein CBFA2T3; transcriptional corepressor CBFA2T3; translocated to, 3", "tax_id": 9031, "disease": "", "pathway": " (gga:415846)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;15649458", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851739.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000248.1. On Sep 23, 2021 this sequence version replaced NP_001025751.1., [RefSeq]; Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Regulates the proliferation and the differentiation of erythroid progenitors. Plays a role in granulocyte differentiation. May also function as an A-kinase-anchoring protein (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q5IJ74;Q5IJ75", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5F3B1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F3N6-1", "uniprot_id": [ { "id": "BAP1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F3N6", "type": "external" } ], "mass": 77704.0, "length": 700, "protein_name": "Ubiquitin carboxyl-terminal hydrolase BAP1", "gene_name": "BAP1", "organism": "Chicken", "refseq_name": "ubiquitin carboxyl-terminal hydrolase BAP1", "refseq_ac": [ { "id": "NP_001025761", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025761", "type": "external" } ], "gene_names_uniprotkb": "BAP1; RCJMB04_11f19", "gene_names_refseq": "BAP1", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase BAP1; 3.4.19.12; BRCA1-associated protein 1", "protein_names_refseq": "BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase); ubiquitin carboxyl-terminal hydrolase BAP1", "tax_id": 9031, "disease": "", "pathway": " (gga:415944)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267658.22203.1, SRR13267649.178950.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000252.1. On Jan 28, 2021 this sequence version replaced NP_001025761.1., [RefSeq]; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0035517 PR-DUB complex", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0045892 negative regulation of DNA-templated transcription;GO:0001558 regulation of cell growth;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F3N6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F3R2-1", "uniprot_id": [ { "id": "KDM5B_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F3R2", "type": "external" } ], "mass": 173462.0, "length": 1522, "protein_name": "Lysine-specific demethylase 5B", "gene_name": "KDM5B", "organism": "Chicken", "refseq_name": "lysine-specific demethylase 5B", "refseq_ac": [ { "id": "NP_001026200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026200", "type": "external" } ], "gene_names_uniprotkb": "KDM5B; JARID1B; RCJMB04_9d3", "gene_names_refseq": "JARID1B; KDM5B", "protein_names_uniprotkb": "Lysine-specific demethylase 5B; 1.14.11.67; Histone demethylase JARID1B; Jumonji/ARID domain-containing protein 1B; [histone H3]-trimethyl-L-lysine(4) demethylase 5B", "protein_names_refseq": "Jumonji, AT rich interactive domain 1B (RBP2-like); [histone H3]-trimethyl-L-lysine(4) demethylase 5B; histone demethylase JARID1B; jumonji/ARID domain-containing protein 1B; lysine (K)-specific demethylase 5B; lysine-specific demethylase 5B", "tax_id": 9031, "disease": "", "pathway": " (gga:421168)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851588.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000356.1. On Aug 8, 2005 this sequence version replaced XP_419248.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor. May repress the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.67", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.67", "type": "external" } ], "go_molecular_function": "GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0032453 histone H3K4 demethylase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F3R2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F3T9-1", "uniprot_id": [ { "id": "UGDH_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F3T9", "type": "external" } ], "mass": 55064.0, "length": 494, "protein_name": "UDP-glucose 6-dehydrogenase", "gene_name": "UGDH", "organism": "Chicken", "refseq_name": "UDP-glucose 6-dehydrogenase isoform 2", "refseq_ac": [ { "id": "NP_001012599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012599", "type": "external" } ], "gene_names_uniprotkb": "UGDH; RCJMB04_7d7", "gene_names_refseq": "UDP-GlcDH; UDPGDH; UGDH", "protein_names_uniprotkb": "UDP-glucose 6-dehydrogenase; 1.1.1.22; UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH", "protein_names_refseq": "UDP-Glc dehydrogenase; UDP-glucose 6-dehydrogenase isoform 2; UDP-glucose dehydrogenase", "tax_id": 9031, "disease": "", "pathway": " (gga:422792)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;20717929", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851561.1, SRR13267652.7972.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Feb 28, 2005 this sequence version replaced XP_420744.1., [RefSeq]; Catalyzes the formation of UDP-alpha-D-glucuronate, a constituent of complex glycosaminoglycans (By similarity). Required for the biosynthesis of chondroitin sulfate and heparan sulfate. Required for embryonic development via its role in the biosynthesis of glycosaminoglycans (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These results indicate a more diverse role for UGDH in the support of selective Glycosaminoglycans production than previously described., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.22", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0003979 UDP-glucose 6-dehydrogenase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001702 gastrulation with mouth forming second;GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0006065 UDP-glucuronate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5F3T9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F3W5-1", "uniprot_id": [ { "id": "SUV92_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F3W5", "type": "external" } ], "mass": 46659.0, "length": 407, "protein_name": "Histone-lysine N-methyltransferase SUV39H2", "gene_name": "SUV39H2", "organism": "Chicken", "refseq_name": "histone-lysine N-methyltransferase SUV39H2", "refseq_ac": [ { "id": "NP_001026541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026541", "type": "external" } ], "gene_names_uniprotkb": "SUV39H2; RCJMB04_5f7", "gene_names_refseq": "SUV39H2", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SUV39H2; 2.1.1.-; Su(var)3-9 homolog 2; Suppressor of variegation 3-9 homolog 2", "protein_names_refseq": "histone-lysine N-methyltransferase SUV39H2; su(var)3-9 homolog 2", "tax_id": 9031, "disease": "", "pathway": " (gga:426314)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851535.1, SRR13267661.21449.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000011.1. On Aug 8, 2005 this sequence version replaced XP_423976.1., [RefSeq]; Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H2 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046974 histone H3K9 methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding;GO:0140947 histone H3K9me2 methyltransferase activity;GO:0140949 histone H3K9 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0031508 pericentric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F3W5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F433-1", "uniprot_id": [ { "id": "PRAF3_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F433", "type": "external" } ], "mass": 21652.0, "length": 188, "protein_name": "PRA1 family protein 3", "gene_name": "ARL6IP5", "organism": "Chicken", "refseq_name": "PRA1 family protein 3", "refseq_ac": [ { "id": "NP_001012623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012623", "type": "external" } ], "gene_names_uniprotkb": "ARL6IP5; PRAF3; RCJMB04_3k9", "gene_names_refseq": "ARL6IP5; PRAF3", "protein_names_uniprotkb": "PRA1 family protein 3; ADP-ribosylation factor-like protein 6-interacting protein 5; ARL-6-interacting protein 5; Aip-5", "protein_names_refseq": "ADP-ribosylation factor-like 6 interacting protein 5; ADP-ribosylation factor-like protein 6-interacting protein 5; ADP-ribosylation-like factor 6 interacting protein 5; ARL-6-interacting protein 5; PRA1 family protein 3; aip-5; cytoskeleton related vitamin A responsive protein", "tax_id": 9031, "disease": "", "pathway": " (gga:426074); (R-GGA-210500)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01001039.1, HAEK01023954.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000252.1. On Feb 28, 2005 this sequence version replaced XP_423751.1., [RefSeq]; Regulates intracellular concentrations of taurine and glutamate. Negatively modulates SLC1A1/EAAC1 glutamate transport activity by decreasing its affinity for glutamate in a PKC activity-dependent manner. May be involved in membrane traffic., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0099523 presynaptic cytosol", "go_biological_process": "GO:0002037 negative regulation of L-glutamate import across plasma membrane;GO:0043065 positive regulation of apoptotic process;GO:0010917 negative regulation of mitochondrial membrane potential;GO:0051051 negative regulation of transport;GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F433-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F485-1", "uniprot_id": [ { "id": "DDX42_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F485", "type": "external" } ], "mass": 103054.0, "length": 944, "protein_name": "ATP-dependent RNA helicase DDX42", "gene_name": "DDX42", "organism": "Chicken", "refseq_name": "ATP-dependent RNA helicase DDX42", "refseq_ac": [ { "id": "NP_001026097", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026097", "type": "external" } ], "gene_names_uniprotkb": "DDX42; RCJMB04_2e15", "gene_names_refseq": "DDX42", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX42; 3.6.4.13; DEAD box protein 42", "protein_names_refseq": "ATP-dependent RNA helicase DDX42; DEAD (Asp-Glu-Ala-Asp) box helicase 42; DEAD (Asp-Glu-Ala-Asp) box polypeptide 42; DEAD box protein 42", "tax_id": 9031, "disease": "", "pathway": " (gga:419959)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851415.1, SRR13267654.130547.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ851415.1. On Aug 8, 2005 this sequence version replaced XP_418081.1., [RefSeq]; ATP-dependent RNA helicase that binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Also mediates RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Required for assembly of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs: DDX42 associates transiently with the SF3B subcomplex of the 17S U2 SnRNP complex and is released after fulfilling its role in the assembly of 17S U2 SnRNP., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071004 U2-type prespliceosome", "go_biological_process": "GO:0042981 regulation of apoptotic process;GO:0008104 intracellular protein localization;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F485-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F4B1-1", "uniprot_id": [ { "id": "PGP_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F4B1", "type": "external" } ], "mass": 32996.0, "length": 312, "protein_name": "Phosphoglycolate phosphatase", "gene_name": "PGP", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PGP; RCJMB04_1e2", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphoglycolate phosphatase; 3.1.3.18; 3.1.3.21; 3.1.3.48; AUM; Aspartate-based ubiquitous Mg(2+)-dependent phosphatase; G3PP; Glycerol-3-phosphate phosphatase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:416559)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Phosphatase with activity against multiple substrates (By similarity). Acts as a metabolite repair enzyme which eliminates toxic glycolytic side products (By similarity). Dephosphorylates 2-phosphoglycolate which is generated during the repair of oxidative DNA lesions (By similarity). Dephosphorylates 4-phosphoerythronate, a side product which is produced by GAPDH and which inhibits 6-phosphogluconate dehydrogenase (By similarity). Dephosphorylation of 4-phosphoerythronate prevents the accumulation of high 4-phosphoerythronate levels which would otherwise inhibit the pentose phosphate pathway (By similarity). Dephosphorylates 2-phospho-L-lactate which is a product of a pyruvate kinase side reaction (By similarity). This prevents the inhibition of fructose-2,6-bisphosphate production and allows glycolysis to occur (By similarity). Has glycerol-3-phosphate phosphatase activity, hydrolyzing glycerol-3-phosphate into glycerol and thereby regulating the cellular levels of glycerol-3-phosphate, a metabolic intermediate of glucose, lipid and energy metabolism (By similarity). Has been shown to have tyrosine-protein phosphatase activity although the physiological relevance is unclear (By similarity). In vitro, has phosphatase activity toward ADP, ATP, GDP and GTP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008967 phosphoglycolate phosphatase activity;GO:0000121 sn-glycerol 1-phosphatase activity;GO:0043136 sn-glycerol 3-phosphatase activity;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0006114 glycerol biosynthetic process;GO:0045721 negative regulation of gluconeogenesis;GO:0110052 toxic metabolite repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F4B1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5MNV6-1", "uniprot_id": [ { "id": "ZNT7_CHICK", "url": "https://www.uniprot.org/uniprot/Q5MNV6", "type": "external" } ], "mass": 41989.0, "length": 378, "protein_name": "Zinc transporter 7", "gene_name": "SLC30A7", "organism": "Chicken", "refseq_name": "zinc transporter 7", "refseq_ac": [ { "id": "NP_001008788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008788", "type": "external" } ], "gene_names_uniprotkb": "SLC30A7; ZNT7", "gene_names_refseq": "SLC30A7; ZNT7", "protein_names_uniprotkb": "Zinc transporter 7; Solute carrier family 30 member 7", "protein_names_refseq": "solute carrier family 30 (zinc transporter), member 7; zinc transporter 7; znT-7", "tax_id": 9031, "disease": "", "pathway": " (gga:424464)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15525635;15994300;16636052", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01001888.1, HAEK01074480.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000239.1. On Jan 3, 2005 this sequence version replaced XP_422307.1., [RefSeq]; Contributes to the conversion of apo-alkaline phosphatase to holo-alkaline phosphatase, [RefSeq, PubMed]; Zinc ion transporter mediating zinc entry from the cytosol into the lumen of organelles along the secretory pathway (PubMed:15525635, PubMed:15994300, PubMed:16636052). By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases (PubMed:15525635, PubMed:15994300, PubMed:16636052)., [UniProtKB, PubMed, PubMed, PubMed]; ZnT5(-)ZnT7(-/-) cells showed exacerbation of the unfolded protein response as did the wild-type cells cultured under a zinc-deficient condition, revealing that both complexes play a role in homeostatic maintenance of secretory pathway function, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:1990674 Golgi cis cisterna membrane;GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006882 intracellular zinc ion homeostasis;GO:1904257 zinc ion import into Golgi lumen", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5MNV6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5NDE8-1", "uniprot_id": [ { "id": "PMGT2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5NDE8", "type": "external" } ], "mass": 66754.0, "length": 577, "protein_name": "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2", "gene_name": "POMGNT2", "organism": "Chicken", "refseq_name": "protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2", "refseq_ac": [ { "id": "NP_001012294", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012294", "type": "external" } ], "gene_names_uniprotkb": "POMGNT2; AGO61; GTDC2", "gene_names_refseq": "AGO61; C2H3ORF39; C3orf39; GTDC2; MDDGA8; POMGNT2", "protein_names_uniprotkb": "Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2; 2.4.1.312; Extracellular O-linked N-acetylglucosamine transferase-like; Glycosyltransferase-like domain-containing protein 2; POMGnT2", "protein_names_refseq": "extracellular O-linked N-acetylglucosamine transferase-like; glycosyltransferase-like domain containing 2; glycosyltransferase-like domain-containing protein 2; glycosyltransferase; protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2", "tax_id": 9031, "disease": "", "pathway": " (gga:428446); (R-GGA-8932505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01015266.1, SRR12888502.21018.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000037.1. On or before Dec 14, 2021 this sequence version replaced XP_015137060.1, XP_426006.1., [RefSeq]; O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.312", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.312", "type": "external" } ], "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity;GO:0008375 acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001764 neuron migration;GO:0006493 protein O-linked glycosylation;GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q5NDE8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QJC2-1", "uniprot_id": [ { "id": "DCR1C_CHICK", "url": "https://www.uniprot.org/uniprot/Q5QJC2", "type": "external" } ], "mass": 80677.0, "length": 714, "protein_name": "Protein artemis", "gene_name": "DCLRE1C", "organism": "Chicken", "refseq_name": "protein artemis", "refseq_ac": [ { "id": "NP_001026765", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026765", "type": "external" } ], "gene_names_uniprotkb": "DCLRE1C; SNM1C", "gene_names_refseq": "DCLRE1C; SNM1C; artemis; nuclease", "protein_names_uniprotkb": "Protein artemis; 3.1.-.-; DNA cross-link repair 1C protein; SNM1 homolog C; SNM1-like protein; chSNM1C", "protein_names_refseq": "DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae); DNA cross-link repair 1C protein; SNM1 homolog C; SNM1-like protein; chSNM1C; protein artemis", "tax_id": 9031, "disease": "", "pathway": " (gga:430764); (R-GGA-5693571)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15572677;18674614;34387696", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY376898.1, SRR13267659.228183.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000011.1. On Dec 8, 2021 this sequence version replaced NP_001026765.1., [RefSeq]; KU70 and DNA-PKcs unexpectedly function together during the induction of apoptosis., [RefSeq, PubMed]; Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation, and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (By similarity)., [UniProtKB]; Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0004519 endonuclease activity;GO:0035312 5'-3' DNA exonuclease activity", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0005634 nucleus", "go_biological_process": "GO:0006310 DNA recombination;GO:0000723 telomere maintenance;GO:0002250 adaptive immune response;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5QJC2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QJC3-1", "uniprot_id": [ { "id": "DCR1B_CHICK", "url": "https://www.uniprot.org/uniprot/Q5QJC3", "type": "external" } ], "mass": 50830.0, "length": 457, "protein_name": "5' exonuclease Apollo", "gene_name": "DCLRE1B", "organism": "Chicken", "refseq_name": "5' exonuclease Apollo", "refseq_ac": [ { "id": "NP_001026671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026671", "type": "external" } ], "gene_names_uniprotkb": "DCLRE1B; SNM1B", "gene_names_refseq": "DCLRE1B; SNM1B", "protein_names_uniprotkb": "5' exonuclease Apollo; 3.1.-.-; 3.5.2.6; Beta-lactamase MBLAC2; DNA cross-link repair 1B protein; SNM1 homolog B", "protein_names_refseq": "5' exonuclease Apollo; DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae); SNM1 homolog B; beta-lactamase MBLAC2", "tax_id": 9031, "disease": "", "pathway": " (gga:428269)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15572677", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY376897.1, BX950430.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992453 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY376897.1. On Mar 27, 2015 this sequence version replaced NP_001026671.2., [RefSeq]; 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways (By similarity). May be required for DNA interstrand cross-link repair (PubMed:15572677). Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (By similarity). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.13.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.19", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0008409 5'-3' exonuclease activity;GO:0008800 beta-lactamase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0000723 telomere maintenance;GO:0031848 protection from non-homologous end joining at telomere;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0036297 interstrand cross-link repair;GO:0031627 telomeric loop formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5QJC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5QJC4-1", "uniprot_id": [ { "id": "DCR1A_CHICK", "url": "https://www.uniprot.org/uniprot/Q5QJC4", "type": "external" } ], "mass": 108328.0, "length": 972, "protein_name": "DNA cross-link repair 1A protein", "gene_name": "DCLRE1A", "organism": "Chicken", "refseq_name": "DNA cross-link repair 1A protein", "refseq_ac": [ { "id": "NP_001008683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008683", "type": "external" } ], "gene_names_uniprotkb": "DCLRE1A; SNM1A", "gene_names_refseq": "DCLRE1A; SNM1A", "protein_names_uniprotkb": "DNA cross-link repair 1A protein; 3.5.2.6; Beta-lactamase MBLAC2; SNM1 homolog A; chSNM1A", "protein_names_refseq": "DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae); DNA cross-link repair 1A protein; SNM1 homolog A; beta-lactamase MBLAC2; chSNM1A", "tax_id": 9031, "disease": "", "pathway": " (gga:423902); (R-GGA-353248); (R-GGA-353303)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12773817;15572677;15642098;1764072", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY376896.1, SRR13267659.146100.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000232.1. On Dec 20, 2004 this sequence version replaced XP_421765.1., [RefSeq]; May be required for DNA interstrand cross-link repair., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.13.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.19", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0008800 beta-lactamase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006303 double-strand break repair via nonhomologous end joining;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5QJC4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5S7W5-1", "uniprot_id": [ { "id": "NTAL_CHICK", "url": "https://www.uniprot.org/uniprot/Q5S7W5", "type": "external" } ], "mass": 22277.0, "length": 198, "protein_name": "Linker for activation of T-cells family member 2", "gene_name": "LAT2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LAT2; LAB; NTAL", "gene_names_refseq": "", "protein_names_uniprotkb": "Linker for activation of T-cells family member 2; Linker for activation of B-cells; Non-T-cell activation linker", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:417489)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15539154", "class_list": "", "function": "Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells. May also be involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization through the recruitment of GRB2., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0042113 B cell activation;GO:0002250 adaptive immune response;GO:0050853 B cell receptor signaling pathway;GO:0043303 mast cell degranulation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5S7W5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZHS0-1", "uniprot_id": [ { "id": "ABRX1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZHS0", "type": "external" } ], "mass": 46043.0, "length": 405, "protein_name": "BRCA1-A complex subunit Abraxas 1", "gene_name": "ABRAXAS1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ABRAXAS1; ABRA1; CCDC98; FAM175A; RCJMB04_33o10", "gene_names_refseq": "", "protein_names_uniprotkb": "BRCA1-A complex subunit Abraxas 1; Coiled-coil domain-containing protein 98; Protein FAM175A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "15592404;15642098", "class_list": "", "function": "Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0008608 attachment of spindle microtubules to kinetochore;GO:0090307 mitotic spindle assembly;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZHS0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZHT1-1", "uniprot_id": [ { "id": "ACD11_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZHT1", "type": "external" } ], "mass": 87002.0, "length": 777, "protein_name": "Acyl-CoA dehydrogenase family member 11", "gene_name": "ACAD11", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ACAD11; RCJMB04_33j3", "gene_names_refseq": "", "protein_names_uniprotkb": "Acyl-CoA dehydrogenase family member 11; 1.3.8.8; ACAD-11", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:420689)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Participates in fatty acid beta-oxidation (FAO) and energy production in the central nervous system (CNS), and to a lesser extent in the liver. Catalyzes the first step in FAO, which consists in the proR-proR stereospecific alpha,beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, with maximal activity towards saturated docosanoyl-CoA (CoA 22:0) in both the cerebellum and the liver. Among the different mitochondrial acyl-CoA dehydrogenases, its FAO activity overlaps with that of ACADV and ACADL, but plays a primary role in tissues where it is the main long-chain ACAD expressed, such as the CNS, where together with ACAD9, they accommodate the full spectrum of long chain fatty acid substrates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity;GO:0050660 flavin adenine dinucleotide binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZHT1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZHY5-1", "uniprot_id": [ { "id": "CHIP_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZHY5", "type": "external" } ], "mass": 35661.0, "length": 314, "protein_name": "E3 ubiquitin-protein ligase CHIP", "gene_name": "STUB1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "STUB1; RCJMB04_32b21", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CHIP; 2.3.2.27; RING-type E3 ubiquitin transferase CHIP; STIP1 homology and U box-containing protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:426918)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation (By similarity). Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030018 Z disc", "go_biological_process": "GO:0006281 DNA repair;GO:0007165 signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZHY5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZHZ0-1", "uniprot_id": [ { "id": "DX39B_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZHZ0", "type": "external" } ], "mass": 49003.0, "length": 428, "protein_name": "Spliceosome RNA helicase DDX39B", "gene_name": "DDX39B", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DDX39B; BAT1; RCJMB04_32b9; UAP56", "gene_names_refseq": "", "protein_names_uniprotkb": "Spliceosome RNA helicase DDX39B; 3.6.4.13; 56 kDa U2AF65-associated protein; DEAD box protein UAP56", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Involved in nuclear export of spliced and unspliced mRNA. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. The TREX complex is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Involved in transcription elongation and genome stability., [UniProtKB, UniProtKB]; Splice factor that is required for the first ATP-dependent step in spliceosome assembly and for the interaction of U2 snRNP with the branchpoint. Has both RNA-stimulated ATP binding/hydrolysis activity and ATP-dependent RNA unwinding activity. Even with the stimulation of RNA, the ATPase activity is weak. Can only hydrolyze ATP but not other NTPs. The RNA stimulation of ATPase activity does not have a strong preference for the sequence and length of the RNA. However, ssRNA stimulates the ATPase activity much more strongly than dsRNA. Can unwind 5' or 3' overhangs or blunt end RNA duplexes in vitro. The ATPase and helicase activities are not influenced by U2AF2; the effect of ALYREF/THOC4 is reported conflictingly (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZHZ0-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZHZ4-1", "uniprot_id": [ { "id": "HAKAI_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZHZ4", "type": "external" } ], "mass": 54851.0, "length": 493, "protein_name": "E3 ubiquitin-protein ligase Hakai", "gene_name": "CBLL1", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase Hakai isoform 1", "refseq_ac": [ { "id": "NP_001007849", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007849", "type": "external" } ], "gene_names_uniprotkb": "CBLL1; HAKAI; RCJMB04_31p12", "gene_names_refseq": "CBLL1; HAKAI", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Hakai; 2.3.2.27; Casitas B-lineage lymphoma-transforming sequence-like protein 1; RING-type E3 ubiquitin transferase Hakai; c-Cbl-like protein 1", "protein_names_refseq": "Cas-Br-M (murine) ecotropic retroviral transforming sequence-like 1; Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1; E3 ubiquitin-protein ligase Hakai isoform 1; E3 ubiquitin-protein ligase Hakai; RING-type E3 ubiquitin transferase Hakai; c-Cbl-like protein 1; casitas B-lineage lymphoma-transforming sequence-like protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:417701)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720990.1, SRR12888552.409094.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1, BM485951.1, BM440308.1, BI066854.1, BU379251.1, AJ394917.1 and AJ727912.1. On Dec 15, 2004 this sequence version replaced XP_415946.1. Transcript Variant: This variant (1) has the long third exon. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates. Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0006397 mRNA processing;GO:0007162 negative regulation of cell adhesion;GO:0030155 regulation of cell adhesion;GO:0030335 positive regulation of cell migration;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZHZ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZI23-1", "uniprot_id": [ { "id": "GLO2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZI23", "type": "external" } ], "mass": 34224.0, "length": 310, "protein_name": "Hydroxyacylglutathione hydrolase, mitochondrial", "gene_name": "HAGH", "organism": "Chicken", "refseq_name": "hydroxyacylglutathione hydrolase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001012807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012807", "type": "external" } ], "gene_names_uniprotkb": "HAGH; RCJMB04_31d24", "gene_names_refseq": "HAGH", "protein_names_uniprotkb": "Hydroxyacylglutathione hydrolase, mitochondrial; 3.1.2.6; Glx II; Glyoxalase II", "protein_names_refseq": "glx II; glyoxalase II; hydroxyacylglutathione hydrolase, mitochondrial precursor; hydroxyacylglutathione hydrolase, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (gga:416537)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01090135.1, HAEL01002646.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992453 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000257.1. On Sep 23, 2021 this sequence version replaced NP_001012807.1., [RefSeq]; Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.6", "type": "external" } ], "go_molecular_function": "GO:0004416 hydroxyacylglutathione hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione;GO:0019853 L-ascorbic acid biosynthetic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZI23-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZI49-1", "uniprot_id": [ { "id": "PRPS2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZI49", "type": "external" } ], "mass": 35663.0, "length": 325, "protein_name": "Ribose-phosphate pyrophosphokinase 2", "gene_name": "PRPS2", "organism": "Chicken", "refseq_name": "ribose-phosphate pyrophosphokinase 2", "refseq_ac": [ { "id": "NP_001006264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006264", "type": "external" } ], "gene_names_uniprotkb": "PRPS2; RCJMB04_30f3", "gene_names_refseq": "PRPS2", "protein_names_uniprotkb": "Ribose-phosphate pyrophosphokinase 2; 2.7.6.1; PRS-II; Phosphoribosyl pyrophosphate synthase II", "protein_names_refseq": "PRS-II; phosphoribosyl pyrophosphate synthase II; phosphoribosyl pyrophosphate synthetase II; ribose-phosphate pyrophosphokinase 2", "tax_id": 9031, "disease": "", "pathway": " (gga:418639)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720935.1, HAEL01011522.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000024.1. On Jan 13, 2005 this sequence version replaced XP_416837.1., [RefSeq]; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.6.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0016301 kinase activity;GO:0004749 ribose phosphate diphosphokinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006098 pentose-phosphate shunt;GO:0009156 ribonucleoside monophosphate biosynthetic process;GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process;GO:0009165 nucleotide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZI49-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZI74-1", "uniprot_id": [ { "id": "DHX30_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZI74", "type": "external" } ], "mass": 137703.0, "length": 1231, "protein_name": "ATP-dependent RNA helicase DHX30", "gene_name": "DHX30", "organism": "Chicken", "refseq_name": "ATP-dependent RNA helicase DHX30 precursor", "refseq_ac": [ { "id": "NP_001012869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012869", "type": "external" } ], "gene_names_uniprotkb": "DHX30; RCJMB04_29l1", "gene_names_refseq": "DHX30", "protein_names_uniprotkb": "ATP-dependent RNA helicase DHX30; 3.6.4.13; DEAH box protein 30", "protein_names_refseq": "ATP-dependent RNA helicase DHX30 precursor; DEAH (Asp-Glu-Ala-His) box helicase 30; DEAH (Asp-Glu-Ala-His) box polypeptide 30; DEAH box protein 30; DEAH-box helicase 30; putative ATP-dependent RNA helicase DHX30", "tax_id": 9031, "disease": "", "pathway": " (gga:420376)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720910.1, SRR13267649.222240.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000035.1. On Sep 23, 2021 this sequence version replaced NP_001012869.1., [RefSeq]; RNA-dependent helicase. Plays an important role in the assembly of the mitochondrial large ribosomal subunit. Required for optimal function of the zinc-finger antiviral protein ZC3HAV1. Associates with mitochondrial DNA. Involved in nervous system development and differentiation through its involvement in the up-regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0002151 G-quadruplex RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0007417 central nervous system development;GO:0042254 ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZI74-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZI87-1", "uniprot_id": [ { "id": "TBCD_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZI87", "type": "external" } ], "mass": 113662.0, "length": 1019, "protein_name": "Tubulin-specific chaperone D", "gene_name": "TBCD", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TBCD; RCJMB04_29e8", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubulin-specific chaperone D; Beta-tubulin cofactor D; Tubulin-folding cofactor D", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:417334)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Tubulin-folding protein implicated in the first step of the tubulin folding pathway and required for tubulin complex assembly. Involved in the regulation of microtubule polymerization or depolymerization, it modulates microtubule dynamics by capturing GTP-bound beta-tubulin (TUBB). Its ability to interact with beta tubulin is regulated via its interaction with ARL2. Acts as a GTPase-activating protein (GAP) for ARL2. Induces microtubule disruption in absence of ARL2. Increases degradation of beta tubulin, when overexpressed in polarized cells. Promotes epithelial cell detachment, a process antagonized by ARL2. Induces tight adherens and tight junctions disassembly at the lateral cell membrane. Required for correct assembly and maintenance of the mitotic spindle, and proper progression of mitosis. Involved in neuron morphogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0048487 beta-tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0006457 protein folding;GO:0070830 bicellular tight junction assembly;GO:0000226 microtubule cytoskeleton organization;GO:0010812 negative regulation of cell-substrate adhesion;GO:0007021 tubulin complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZI87-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZID5-1", "uniprot_id": [ { "id": "UBP28_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZID5", "type": "external" } ], "mass": 118747.0, "length": 1047, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 28", "gene_name": "USP28", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "USP28; RCJMB04_27l24", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 28; 3.4.19.12; Deubiquitinating enzyme 28; Ubiquitin thioesterase 28; Ubiquitin-specific-processing protease 28", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:428246)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Deubiquitinase involved in DNA damage response checkpoint and MYC proto-oncogene stability. Involved in DNA damage induced apoptosis by specifically deubiquitinating proteins of the DNA damage pathway such as CLSPN. Also involved in G2 DNA damage checkpoint, by deubiquitinating CLSPN, and preventing its degradation by the anaphase promoting complex/cyclosome (APC/C). Specifically deubiquitinates MYC in the nucleoplasm, leading to prevent MYC degradation by the proteasome. Deubiquitinates ZNF304, hence may prevent ZNF304 degradation by the proteasome, leading to the activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0008283 cell population proliferation;GO:0016579 protein deubiquitination;GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZID5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZIK0-1", "uniprot_id": [ { "id": "P4K2B_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZIK0", "type": "external" } ], "mass": 53922.0, "length": 479, "protein_name": "Phosphatidylinositol 4-kinase type 2-beta", "gene_name": "PI4K2B", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PI4K2B; RCJMB04_25j21", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphatidylinositol 4-kinase type 2-beta; 2.7.1.67; Phosphatidylinositol 4-kinase type II-beta", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:422807)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.67", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004430 1-phosphatidylinositol 4-kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007032 endosome organization;GO:0007030 Golgi organization;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZIK0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZIR9-1", "uniprot_id": [ { "id": "RN185_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZIR9", "type": "external" } ], "mass": 20828.0, "length": 194, "protein_name": "E3 ubiquitin-protein ligase RNF185", "gene_name": "RNF185", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase RNF185", "refseq_ac": [ { "id": "NP_001007841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007841", "type": "external" } ], "gene_names_uniprotkb": "RNF185; RCJMB04_23p11", "gene_names_refseq": "RNF185; RNF5", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF185; 2.3.2.27; RING finger protein 185", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF185; RING-type E3 ubiquitin transferase RNF185; ring finger protein 185", "tax_id": 9031, "disease": "", "pathway": " (gga:416965)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720715.1, HAEK01013321.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000260.1. On Dec 15, 2004 this sequence version replaced XP_415258.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0044390 ubiquitin-like protein conjugating enzyme binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006914 autophagy;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZIR9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZIU9-1", "uniprot_id": [ { "id": "S39A9_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZIU9", "type": "external" } ], "mass": 32192.0, "length": 305, "protein_name": "Zinc transporter ZIP9", "gene_name": "SLC39A9", "organism": "Chicken", "refseq_name": "zinc transporter ZIP9", "refseq_ac": [ { "id": "NP_001007934", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007934", "type": "external" } ], "gene_names_uniprotkb": "SLC39A9; RCJMB04_23h6; ZIP9", "gene_names_refseq": "SLC39A9; ZIP9", "protein_names_uniprotkb": "Zinc transporter ZIP9; Solute carrier family 39 member 9; ZIP-9; Zrt- and Irt-like protein 9", "protein_names_refseq": "ZIP-9; solute carrier family 39 (zinc transporter), member 9; zinc transporter SLC39A9; zinc transporter ZIP9; zrt- and Irt-like protein 9", "tax_id": 9031, "disease": "", "pathway": " (gga:423261)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15642098;19420709;23505453", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720685.1, HAEL01009090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992559 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000214.1. On Dec 15, 2004 this sequence version replaced XP_421182.1., [RefSeq]; SLC39A9 functions to regulate zinc homeostasis in the secretory pathway without significantly altering cytosolic zinc homeostasis., [RefSeq, PubMed]; Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments (By similarity). Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation (PubMed:23505453). Also functions as a membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (By similarity). Moreover, has dual functions as a membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0004930 G protein-coupled receptor activity;GO:0005497 androgen binding;GO:0022883 zinc efflux transmembrane transporter activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0070830 bicellular tight junction assembly;GO:0006882 intracellular zinc ion homeostasis;GO:1905562 regulation of vascular endothelial cell proliferation;GO:2000654 regulation of cellular response to testosterone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5ZIU9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZIV1-1", "uniprot_id": [ { "id": "MTMR2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZIV1", "type": "external" } ], "mass": 65968.0, "length": 571, "protein_name": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2", "gene_name": "MTMR2", "organism": "Chicken", "refseq_name": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2", "refseq_ac": [ { "id": "NP_001034363", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034363", "type": "external" } ], "gene_names_uniprotkb": "MTMR2; RCJMB04_23g22", "gene_names_refseq": "MTMR2", "protein_names_uniprotkb": "Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2; 3.1.3.95; Myotubularin-related protein 2; Phosphatidylinositol-3-phosphate phosphatase", "protein_names_refseq": "phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR2; phosphatidylinositol-3,5-bisphosphate 3-phosphatase; phosphatidylinositol-3-phosphate phosphatase", "tax_id": 9031, "disease": "", "pathway": " (gga:418992)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720683.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992428, SAMEA103992527 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000027.1. On Sep 23, 2021 this sequence version replaced NP_001034363.1., [RefSeq]; Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" } ], "go_molecular_function": "GO:0004438 phosphatidylinositol-3-phosphate phosphatase activity;GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0031901 early endosome membrane", "go_biological_process": "GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZIV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZIV5-1", "uniprot_id": [ { "id": "PDC10_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZIV5", "type": "external" } ], "mass": 24702.0, "length": 212, "protein_name": "Programmed cell death protein 10", "gene_name": "PDCD10", "organism": "Chicken", "refseq_name": "programmed cell death protein 10", "refseq_ac": [ { "id": "NP_001006554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006554", "type": "external" } ], "gene_names_uniprotkb": "PDCD10; RCJMB04_23e18", "gene_names_refseq": "PDCD10", "protein_names_uniprotkb": "Programmed cell death protein 10", "protein_names_refseq": "programmed cell death protein 10", "tax_id": 9031, "disease": "", "pathway": " (gga:425003)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;21041308", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720679.1, CR387835.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ720679.1. On Jan 13, 2005 this sequence version replaced XP_422810.1., [RefSeq]; PDCD10/CCM3 acts as a critical regulator of neuronal survival during development, [RefSeq, PubMed]; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development. Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0090443 FAR/SIN/STRIPAK complex", "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis;GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZIV5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZIW1-1", "uniprot_id": [ { "id": "PEO1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZIW1", "type": "external" } ], "mass": 73995.0, "length": 669, "protein_name": "Twinkle mtDNA helicase", "gene_name": "TWNK", "organism": "Chicken", "refseq_name": "twinkle mtDNA helicase precursor", "refseq_ac": [ { "id": "NP_001026515", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026515", "type": "external" } ], "gene_names_uniprotkb": "TWNK; PEO1; RCJMB04_23c24", "gene_names_refseq": "C10orf2; C6H10orf2; PEO1; TWNK", "protein_names_uniprotkb": "Twinkle mtDNA helicase; 5.6.2.3; Progressive external ophthalmoplegia 1 protein homolog; Twinkle protein, mitochondrial", "protein_names_refseq": "progressive external ophthalmoplegia 1 protein homolog; twinkle mtDNA helicase precursor; twinkle protein, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (gga:425626)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720673.1, HAEK01004799.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000232.1. On Aug 8, 2005 this sequence version replaced XP_423361.1. Sequence Note: This sequence has been modified as follows: removed 35 bp suspected to be vector contamination from the 3' end., [RefSeq]; Mitochondrial helicase involved in mtDNA replication and repair. Might have a role in mtDNA repair. Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB. Preferentially unwinds DNA substrates with pre-existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate. Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand. In addition to its DNA strand separation activity, also has DNA strand annealing, DNA strand-exchange and DNA branch migration activities., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0008289 lipid binding;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006264 mitochondrial DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZIW1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZIX8-1", "uniprot_id": [ { "id": "KDM3A_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZIX8", "type": "external" } ], "mass": 149333.0, "length": 1325, "protein_name": "Lysine-specific demethylase 3A", "gene_name": "KDM3A", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KDM3A; JHDM2A; JMJD1A; RCJMB04_22o22", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysine-specific demethylase 3A; 1.14.11.65; JmjC domain-containing histone demethylation protein 2A; Jumonji domain-containing protein 1A; [histone H3]-dimethyl-L-lysine(9) demethylase 3A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:422917)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031490 chromatin DNA binding;GO:0003712 transcription coregulator activity;GO:0032454 histone H3K9 demethylase activity;GO:0140683 histone H3K9me/H3K9me2 demethylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZIX8-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJ58-1", "uniprot_id": [ { "id": "PI51B_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJ58", "type": "external" } ], "mass": 60719.0, "length": 540, "protein_name": "Phosphatidylinositol 4-phosphate 5-kinase type-1 beta", "gene_name": "PIP5K1B", "organism": "Chicken", "refseq_name": "phosphatidylinositol 4-phosphate 5-kinase type-1 beta", "refseq_ac": [ { "id": "NP_001026593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026593", "type": "external" } ], "gene_names_uniprotkb": "PIP5K1B; RCJMB04_20j15", "gene_names_refseq": "PIP5K1B", "protein_names_uniprotkb": "Phosphatidylinositol 4-phosphate 5-kinase type-1 beta; 2.7.1.68; PIP5K1-beta; PIP5KIbeta; Phosphatidylinositol 4-phosphate 5-kinase type I beta; PtdIns(4)P-5-kinase 1 beta; Type I phosphatidylinositol 4-phosphate 5-kinase beta", "protein_names_refseq": "PIP5K1-beta; PIP5KIbeta; phosphatidylinositol 4-phosphate 5-kinase type-1 beta; phosphatidylinositol-4-phosphate 5-kinase, type I, beta; ptdIns(4)P-5-kinase 1 beta; type I phosphatidylinositol 4-phosphate 5-kinase beta", "tax_id": 9031, "disease": "", "pathway": " (gga:427243)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720576.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000094.1. On Sep 23, 2021 this sequence version replaced NP_001026593.1., [RefSeq]; Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility (By similarity). PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.68", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJ58-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJ66-1", "uniprot_id": [ { "id": "SYEM_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJ66", "type": "external" } ], "mass": 56954.0, "length": 502, "protein_name": "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial", "gene_name": "EARS2", "organism": "Chicken", "refseq_name": "nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001026638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026638", "type": "external" } ], "gene_names_uniprotkb": "EARS2; RCJMB04_20f12", "gene_names_refseq": "EARS2; mtGluRS", "protein_names_uniprotkb": "Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial; 6.1.1.17; 6.1.1.24; GluRS; Glutamate--tRNA(Gln) ligase EARS2, mitochondrial; Glutamyl-tRNA synthetase; Mitochondrial glutamyl-tRNA synthetase; mtGluRS", "protein_names_refseq": "gluRS; glutamate--tRNA ligase; glutamate--tRNA(Gln) ligase EARS2, mitochondrial; glutamyl-tRNA synthetase 2, mitochondrial (putative); mitochondrial glutamyl-tRNA synthetase; nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial precursor; nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial; probable glutamate--tRNA ligase, mitochondrial; probable glutamyl-tRNA synthetase, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (gga:427672)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720568.1, HAEK01023911.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000257.1. On Aug 8, 2005 this sequence version replaced XP_425246.1., [RefSeq]; Non-discriminating glutamyl-tRNA synthetase that catalyzes aminoacylation of both mitochondrial tRNA(Glu) and tRNA(Gln) and participates in RNA aminoacylation for mitochondrial protein translation. Attachs glutamate to tRNA(Glu) or tRNA(Gln) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) or tRNA(Gln)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "6.1.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.24", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0004818 glutamate-tRNA ligase activity;GO:0050561 glutamate-tRNA(Gln) ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006424 glutamyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJ66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJD8-1", "uniprot_id": [ { "id": "DIESL_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJD8", "type": "external" } ], "mass": 37968.0, "length": 332, "protein_name": "DGAT1/2-independent enzyme synthesizing storage lipids", "gene_name": "TMEM68", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TMEM68; RCJMB04_19b17", "gene_names_refseq": "", "protein_names_uniprotkb": "DGAT1/2-independent enzyme synthesizing storage lipids; 2.3.1.-; 2.3.1.20; 2.3.1.22; DIESL; MGAT/DGAT; Monoacylglycerol/Diacylglycerol O-acyltransferase; Transmembrane protein 68", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:421124)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Catalytic subunit of the alternative triglyceride biosynthesis pathway, which mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids. Synthesizes triacylglycerol at the expense of membrane phospholipids, such as phosphatidylcholine (PC) and its ether-linked form (ePC), thereby altering the composition of membranes. The alternative triglyceride biosynthesis pathway is probably required to provide the energy required for rapid growth when fuel sources are limiting. It maintains mitochondrial function during periods of extracellular lipid starvation (By similarity). Can also use acyl-CoA as donor: acts as a acyl-CoA:monoacylglycerol acyltransferase (MGAT), but also shows acyl-CoA:diacylglycerol acyltransferase (DGAT) activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "2.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.22", "type": "external" } ], "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity;GO:0046027 phospholipid:diacylglycerol acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0019432 triglyceride biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJD8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJH6-1", "uniprot_id": [ { "id": "ULK3_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJH6", "type": "external" } ], "mass": 53065.0, "length": 468, "protein_name": "Serine/threonine-protein kinase ULK3", "gene_name": "ULK3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ULK3; RCJMB04_18b17", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine/threonine-protein kinase ULK3; 2.7.11.1; Unc-51-like kinase 3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Serine/threonine protein kinase that acts as a regulator of smoothened signaling and autophagy. Acts as a positive regulator of smoothened signaling in the presence of hedgehog (DHH, IHH or SHH) ligand: autophosphorylates and mediates phosphorylation of full-length GLI2, promoting subsequent phosphorylation by CDK1 and GLI2 dissociation from SUFU and translocation to the nucleus. Also phosphorylates as GLI1 and GLI3, although less efficiently., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0000045 autophagosome assembly;GO:0010506 regulation of autophagy;GO:0042594 response to starvation;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJH6-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJH9-1", "uniprot_id": [ { "id": "DKC1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJH9", "type": "external" } ], "mass": 58150.0, "length": 516, "protein_name": "H/ACA ribonucleoprotein complex subunit DKC1", "gene_name": "DKC1", "organism": "Chicken", "refseq_name": "H/ACA ribonucleoprotein complex subunit DKC1", "refseq_ac": [ { "id": "NP_001026286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026286", "type": "external" } ], "gene_names_uniprotkb": "DKC1; RCJMB04_17p9", "gene_names_refseq": "DKC1", "protein_names_uniprotkb": "H/ACA ribonucleoprotein complex subunit DKC1; 5.4.99.-; Dyskerin", "protein_names_refseq": "H/ACA ribonucleoprotein complex subunit DKC1; dyskeratosis congenita 1, dyskerin; h/ACA ribonucleoprotein complex subunit 4", "tax_id": 9031, "disease": "", "pathway": " (gga:422196); (R-GGA-417076)", "pathway_count": 2, "publication_count": 9, "publication_id_list": "11074001;15642098;16121131;16522649;17395830;18308646;18358808;18523010;18612635", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720455.1, HAEL01003657.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000071.1. On Nov 25, 2021 this sequence version replaced NP_001026286.1., [RefSeq]; Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. Required for ribosome biogenesis and telomere maintenance., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.99.25", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25", "type": "external" }, { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0009982 pseudouridine synthase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0015030 Cajal body;GO:0005697 telomerase holoenzyme complex;GO:0031429 box H/ACA snoRNP complex", "go_biological_process": "GO:0000455 enzyme-directed rRNA pseudouridine synthesis;GO:0000495 box H/ACA sno(s)RNA 3'-end processing;GO:0031118 rRNA pseudouridine synthesis;GO:0031120 snRNA pseudouridine synthesis;GO:1990481 mRNA pseudouridine synthesis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q5ZJH9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJJ2-1", "uniprot_id": [ { "id": "RFA1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJJ2", "type": "external" } ], "mass": 68001.0, "length": 614, "protein_name": "Replication protein A 70 kDa DNA-binding subunit", "gene_name": "RPA1", "organism": "Chicken", "refseq_name": "replication protein A 70 kDa DNA-binding subunit", "refseq_ac": [ { "id": "NP_001006221", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006221", "type": "external" } ], "gene_names_uniprotkb": "RPA1; RCJMB04_17l6", "gene_names_refseq": "RPA1", "protein_names_uniprotkb": "Replication protein A 70 kDa DNA-binding subunit; RF-A protein 1; RP-A p70; Replication factor A protein 1", "protein_names_refseq": "RF-A protein 1; RP-A p70; replication factor A protein 1; replication protein A 70 kDa DNA-binding subunit; replication protein A1, 70kDa", "tax_id": 9031, "disease": "", "pathway": " (gga:417563); (R-GGA-110312); (R-GGA-110314); (R-GGA-110320); (R-GGA-174437); (R-GGA-176187); (R-GGA-3108214); (R-GGA-3371453); (R-GGA-351451); (R-GGA-351468); (R-GGA-353303); (R-GGA-5358565); (R-GGA-5358606); (R-GGA-5651801); (R-GGA-5655862); (R-GGA-5656121); (R-GGA-5656169); (R-GGA-5685938); (R-GGA-5685942); (R-GGA-5693537); (R-GGA-5693607); (R-GGA-5696395); (R-GGA-5696397); (R-GGA-5696400); (R-GGA-6782135); (R-GGA-6782210); (R-GGA-6783310); (R-GGA-68962); (R-GGA-69166)", "pathway_count": 29, "publication_count": 8, "publication_id_list": "10449415;11080452;12773817;15066121;15572677;15642098;17575048;1764072", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720442.1, HAEK01008022.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000323.1. On Jan 13, 2005 this sequence version replaced XP_415809.1., [RefSeq]; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0003697 single-stranded DNA binding;GO:0043047 single-stranded telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016605 PML body;GO:0005662 DNA replication factor A complex", "go_biological_process": "GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination;GO:0006289 nucleotide-excision repair;GO:0051321 meiotic cell cycle;GO:0034502 protein localization to chromosome", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q5ZJJ2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJL4-1", "uniprot_id": [ { "id": "CLP1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJL4", "type": "external" } ], "mass": 47594.0, "length": 425, "protein_name": "Polyribonucleotide 5'-hydroxyl-kinase Clp1", "gene_name": "CLP1", "organism": "Chicken", "refseq_name": "polyribonucleotide 5'-hydroxyl-kinase Clp1", "refseq_ac": [ { "id": "NP_001012292", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012292", "type": "external" } ], "gene_names_uniprotkb": "CLP1; RCJMB04_17f4", "gene_names_refseq": "CLP1", "protein_names_uniprotkb": "Polyribonucleotide 5'-hydroxyl-kinase Clp1; 2.7.1.78; Polyadenylation factor Clp1; Polynucleotide kinase Clp1; Pre-mRNA cleavage complex II protein Clp1", "protein_names_refseq": "ATP/GTP-binding protein; CLP1, cleavage and polyadenylation factor I subunit, homolog; polyribonucleotide 5'-hydroxyl-kinase Clp1", "tax_id": 9031, "disease": "", "pathway": " (gga:423131); (R-GGA-9770562)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15592404;15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720420.1, HAEL01000405.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992648 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000214.1. On Sep 23, 2021 this sequence version replaced NP_001012292.1., [RefSeq]; Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by dicer1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1NA64", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" } ], "go_molecular_function": "GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity;GO:0051736 ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity;GO:0005524 ATP binding;GO:0051731 polynucleotide 5'-hydroxyl-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005849 mRNA cleavage factor complex;GO:0000214 tRNA-intron endonuclease complex", "go_biological_process": "GO:0070922 RISC complex assembly;GO:0021695 cerebellar cortex development;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation;GO:0000379 tRNA-type intron splice site recognition and cleavage;GO:0031124 mRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZJL4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJL5-1", "uniprot_id": [ { "id": "PURA2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJL5", "type": "external" } ], "mass": 49455.0, "length": 451, "protein_name": "Adenylosuccinate synthetase isozyme 2", "gene_name": "ADSS2", "organism": "Chicken", "refseq_name": "adenylosuccinate synthetase isozyme 2 isoform 1", "refseq_ac": [ { "id": "NP_001026692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026692", "type": "external" } ], "gene_names_uniprotkb": "ADSS2; ADSS; RCJMB04_17e23", "gene_names_refseq": "ADSS2; ADSS; AdSS 2", "protein_names_uniprotkb": "Adenylosuccinate synthetase isozyme 2; 6.3.4.4; AMPSase 2; AdSS 2; Adenylosuccinate synthetase, acidic isozyme; Adenylosuccinate synthetase, liver isozyme; IMP--aspartate ligase 2; L-type adenylosuccinate synthetase", "protein_names_refseq": "adenylosuccinate synthetase isozyme 2 isoform 1; adenylosuccinate synthetase isozyme 2", "tax_id": 9031, "disease": "", "pathway": " (gga:428579); (R-GGA-421203)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15642098;2111814", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720419.1, HAEK01059873.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000063.1. On Aug 8, 2005 this sequence version replaced XP_426136.1., [RefSeq]; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0004019 adenylosuccinate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0046040 IMP metabolic process;GO:0044208 'de novo' AMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZJL5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJN4-1", "uniprot_id": [ { "id": "UBP10_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJN4", "type": "external" } ], "mass": 86556.0, "length": 785, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 10", "gene_name": "USP10", "organism": "Chicken", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 10", "refseq_ac": [ { "id": "NP_001006130", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006130", "type": "external" } ], "gene_names_uniprotkb": "USP10; RCJMB04_16o18", "gene_names_refseq": "USP10", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 10; 3.4.19.12; Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10", "protein_names_refseq": "deubiquitinating enzyme 10; ubiquitin carboxyl-terminal hydrolase 10; ubiquitin specific protease 10; ubiquitin thioesterase 10; ubiquitin thiolesterase 10; ubiquitin-specific-processing protease 10", "tax_id": 9031, "disease": "", "pathway": " (gga:415817)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720400.1, SRR13267654.234082.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000248.1. On Sep 23, 2021 this sequence version replaced NP_001006130.1., [RefSeq]; Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, RPS2/us5, RPS3/us3, RPS10/eS10, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteracts MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels. Plays a key role in 40S ribosome subunit recycling when a ribosome has stalled during translation: acts both by inhibiting formation of stress granules, which store stalled translation pre-initiation complexes, and mediating deubiquitination of 40S ribosome subunits. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044325 transmembrane transporter binding;GO:0002039 p53 binding;GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0006281 DNA repair;GO:0006508 proteolysis;GO:0010506 regulation of autophagy;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJN4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJN8-1", "uniprot_id": [ { "id": "SELT_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJN8", "type": "external" } ], "mass": 22318.0, "length": 199, "protein_name": "Thioredoxin reductase-like selenoprotein T", "gene_name": "SELENOT", "organism": "Chicken", "refseq_name": "thioredoxin reductase-like selenoprotein T precursor", "refseq_ac": [ { "id": "NP_001006557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006557", "type": "external" } ], "gene_names_uniprotkb": "SELENOT; RCJMB04_16o1", "gene_names_refseq": "SELENOT", "protein_names_uniprotkb": "Thioredoxin reductase-like selenoprotein T; 1.8.1.9; SelT", "protein_names_refseq": "SELT; thioredoxin reductase-like enzyme; thioredoxin reductase-like selenoprotein T precursor; thioredoxin reductase-like selenoprotein T", "tax_id": 9031, "disease": "", "pathway": " (gga:425041)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15642098;24958020;32031748", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ450766.1, AJ720396.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992531, SAMN02738223 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AJ450766.1, DR419695.1, AJ720396.1 and CV862139.1. On Apr 6, 2007 this sequence version replaced NP_001006557.2. This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. [provided by RefSeq, Jul 2017]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data indicate that a selenium -deficient diet led to a decrease in selenoprotein T (SelT), oxidative stress in the chicken immune organs., [RefSeq, PubMed]; Dysfunction of thioredoxin triggers inflammation through activation of autophagy in chicken cardiomyocytes., [RefSeq, PubMed]; Selenoprotein with thioredoxin reductase-like oxidoreductase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.9", "type": "external" }, { "id": "1.11.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.2", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0042593 glucose homeostasis;GO:0031016 pancreas development;GO:0009749 response to glucose;GO:0045454 cell redox homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5ZJN8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJT1-1", "uniprot_id": [ { "id": "HMCES_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJT1", "type": "external" } ], "mass": 38221.0, "length": 336, "protein_name": "Abasic site processing protein HMCES", "gene_name": "HMCES", "organism": "Chicken", "refseq_name": "abasic site processing protein HMCES", "refseq_ac": [ { "id": "NP_001006137", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006137", "type": "external" } ], "gene_names_uniprotkb": "HMCES; RCJMB04_15p13; SRAPD1", "gene_names_refseq": "C12H3ORF37; C3orf37; DC12; HMCES; SRAPD1", "protein_names_uniprotkb": "Abasic site processing protein HMCES; 3.4.-.-; 4.-.-.-; ES cell-specific 5hmC-binding protein; Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Peptidase HMCES; SRAP domain-containing protein 1", "protein_names_refseq": "5-hydroxymethylcytosine (hmC) binding, ES cell-specific; ES cell-specific 5hmC-binding protein; SRAP domain-containing protein 1; UPF0361 protein C3orf37 homolog; abasic site processing protein HMCES; embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; peptidase HMCES; putative endonuclease HMCES; putative peptidase SRAPD1", "tax_id": 9031, "disease": "", "pathway": " (gga:416015)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720353.1, HAEL01011155.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000252.1. On Jan 13, 2005 this sequence version replaced XP_414358.1., [RefSeq]; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (By similarity). The HMCES DNA-protein cross-link is then either reversed or degraded. HMCES is able to catalyze the reversal of its thiazolidine cross-link and cycle between a cross-link and a non-cross-linked state depending on DNA context: mediates self-reversal of the thiazolidine cross-link in double stranded DNA, allowing APEX1 to initiate downstream repair of abasic sites. The HMCES DNA-protein cross-link can also be degraded by the SPRTN metalloprotease following unfolding by the BRIP1/FANCJ helicase (By similarity). Promotes error-free repair of abasic sites by protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). The HMCES DNA-protein cross-link is then either reversed or degraded. According to a model, the HMCES DNA-protein cross-link (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008233 peptidase activity;GO:0003697 single-stranded DNA binding;GO:0140431 DNA-(abasic site) binding;GO:0160129 protein-DNA covalent cross-linking activity", "go_cellular_component": "GO:0005657 replication fork", "go_biological_process": "GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0006508 proteolysis;GO:0006974 DNA damage response;GO:0016446 somatic hypermutation of immunoglobulin genes;GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJT1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJW8-1", "uniprot_id": [ { "id": "DTL_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJW8", "type": "external" } ], "mass": 78633.0, "length": 720, "protein_name": "Denticleless protein homolog", "gene_name": "DTL", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DTL; CDT2; RCJMB04_15a2", "gene_names_refseq": "", "protein_names_uniprotkb": "Denticleless protein homolog", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:421373)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity). May play a role in the regulation of the circadian clock (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005694 chromosome;GO:0031465 Cul4B-RING E3 ubiquitin ligase complex", "go_biological_process": "GO:0051247 positive regulation of protein metabolic process;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0009411 response to UV;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJW8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZJY5-1", "uniprot_id": [ { "id": "SMC5_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZJY5", "type": "external" } ], "mass": 124924.0, "length": 1065, "protein_name": "Structural maintenance of chromosomes protein 5", "gene_name": "SMC5", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SMC5; RCJMB04_14g12; RCJMB04_6o14; SMC5L1", "gene_names_refseq": "", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 5; SMC protein 5; SMC-5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5F3U6", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016605 PML body;GO:0000781 chromosome, telomeric region;GO:0030915 Smc5-Smc6 complex", "go_biological_process": "GO:0051301 cell division;GO:0000724 double-strand break repair via homologous recombination;GO:0090398 cellular senescence;GO:0000722 telomere maintenance via recombination;GO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZJY5-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZK10-1", "uniprot_id": [ { "id": "NSF1C_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZK10", "type": "external" } ], "mass": 40641.0, "length": 369, "protein_name": "NSFL1 cofactor p47", "gene_name": "NSFL1C", "organism": "Chicken", "refseq_name": "NSFL1 cofactor p47", "refseq_ac": [ { "id": "NP_001026030", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026030", "type": "external" } ], "gene_names_uniprotkb": "NSFL1C; RCJMB04_13o20", "gene_names_refseq": "NSFL1C", "protein_names_uniprotkb": "NSFL1 cofactor p47; p97 cofactor p47", "protein_names_refseq": "NSFL1 (p97) cofactor (p47); NSFL1 cofactor p47; p97 cofactor p47", "tax_id": 9031, "disease": "", "pathway": " (gga:419268); (R-GGA-9013407)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01012129.1, HAEL01008571.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000328.1. On Aug 8, 2005 this sequence version replaced XP_417441.1., [RefSeq]; Reduces the ATPase activity of VCP. Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis. May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Inhibits the activity of CTSL (in vitro). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A levels during mitotic progression by promoting AURKA removal from centrosomes in prophase. Also, regulates spindle orientation during mitosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:1990730 VCP-NSFL1C complex;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005795 Golgi stack", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0000045 autophagosome assembly;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061025 membrane fusion;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZK10-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZK33-1", "uniprot_id": [ { "id": "LETM1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZK33", "type": "external" } ], "mass": 85849.0, "length": 752, "protein_name": "Mitochondrial proton/calcium exchanger protein", "gene_name": "LETM1", "organism": "Chicken", "refseq_name": "mitochondrial proton/calcium exchanger protein", "refseq_ac": [ { "id": "NP_001006461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006461", "type": "external" } ], "gene_names_uniprotkb": "LETM1; RCJMB04_13i11", "gene_names_refseq": "KHE; LETM1", "protein_names_uniprotkb": "Mitochondrial proton/calcium exchanger protein; Electroneutral mitochondrial K(+)/H(+)exchanger; KHE; Leucine zipper-EF-hand-containing transmembrane protein 1", "protein_names_refseq": "LETM1 and EF-hand domain-containing protein 1, mitochondrial; electroneutral mitochondrial K(+)/H(+)exchanger; leucine zipper-EF-hand-containing transmembrane protein 1; mitochondrial proton/calcium exchanger protein", "tax_id": 9031, "disease": "", "pathway": " (gga:422898)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720251.1, SRR13267654.30759.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Sep 28, 2011 this sequence version replaced NP_001006461.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (By similarity). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Also functions as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0043022 ribosome binding;GO:0015369 calcium:proton antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0006816 calcium ion transport;GO:0006813 potassium ion transport;GO:0007005 mitochondrion organization;GO:0006851 mitochondrial calcium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZK33-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZK90-1", "uniprot_id": [ { "id": "ARSK_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZK90", "type": "external" } ], "mass": 61401.0, "length": 535, "protein_name": "Arylsulfatase K", "gene_name": "ARSK", "organism": "Chicken", "refseq_name": "arylsulfatase K precursor", "refseq_ac": [ { "id": "NP_001026586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026586", "type": "external" } ], "gene_names_uniprotkb": "ARSK", "gene_names_refseq": "ARSK", "protein_names_uniprotkb": "Arylsulfatase K; 3.1.6.18; 3.1.6.1; ASK; Glucuronate-2-sulfatase", "protein_names_refseq": "ASK; arylsulfatase K precursor; arylsulfatase K; glucuronate-2-sulfatase", "tax_id": 9031, "disease": "", "pathway": " (gga:427116)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720194.1, SRR13267648.19025.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000095.1. On Aug 8, 2005 this sequence version replaced XP_424708.1., [RefSeq]; Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (By similarity). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (By similarity). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.6.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.1", "type": "external" }, { "id": "3.1.6.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.18", "type": "external" }, { "id": "3.1.6.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.15", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004065 arylsulfatase activity;GO:0015024 glucuronate-2-sulfatase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZK90-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKA6-1", "uniprot_id": [ { "id": "WASH1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKA6", "type": "external" } ], "mass": 51683.0, "length": 476, "protein_name": "WASH complex subunit 1", "gene_name": "WASHC1", "organism": "Chicken", "refseq_name": "WASH complex subunit 1", "refseq_ac": [ { "id": "NP_001006245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006245", "type": "external" } ], "gene_names_uniprotkb": "WASHC1; RCJMB04_12b7; WASH1", "gene_names_refseq": "FAM39B; WASH1; WASH2P; WASHC1", "protein_names_uniprotkb": "WASH complex subunit 1; WAS protein family homolog 1", "protein_names_refseq": "WAS protein family homolog 1; WAS protein family homolog 2 pseudogene; WASH complex subunit 1; family with sequence similarity 39, member B", "tax_id": 9031, "disease": "", "pathway": " (gga:418145)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720178.1, SRR13267654.88882.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. On Sep 23, 2021 this sequence version replaced NP_001006245.1., [RefSeq]; Acts as a nucleation-promoting factor at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0043014 alpha-tubulin binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0015031 protein transport;GO:0016197 endosomal transport;GO:0034314 Arp2/3 complex-mediated actin nucleation;GO:0042147 retrograde transport, endosome to Golgi;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKA6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKB9-1", "uniprot_id": [ { "id": "DDX6_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKB9", "type": "external" } ], "mass": 54418.0, "length": 483, "protein_name": "Probable ATP-dependent RNA helicase DDX6", "gene_name": "DDX6", "organism": "Chicken", "refseq_name": "probable ATP-dependent RNA helicase DDX6", "refseq_ac": [ { "id": "NP_001268976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268976", "type": "external" } ], "gene_names_uniprotkb": "DDX6; RCJMB04_11n24", "gene_names_refseq": "DDX6; RCK", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX6; 3.6.4.13; DEAD box protein 6", "protein_names_refseq": "ATP-dependent RNA helicase p54; DEAD (Asp-Glu-Ala-Asp) box helicase 6; DEAD (Asp-Glu-Ala-Asp) box polypeptide 6; probable ATP-dependent RNA helicase DDX6", "tax_id": 9031, "disease": "", "pathway": " (gga:419783)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720165.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000341.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0017148 negative regulation of translation;GO:0035278 miRNA-mediated gene silencing by inhibition of translation;GO:0033962 P-body assembly;GO:0034063 stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKB9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKD7-1", "uniprot_id": [ { "id": "MOV10_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKD7", "type": "external" } ], "mass": 109051.0, "length": 967, "protein_name": "RNA helicase MOV-10", "gene_name": "MOV10", "organism": "Chicken", "refseq_name": "putative helicase MOV-10", "refseq_ac": [ { "id": "NP_001012861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012861", "type": "external" } ], "gene_names_uniprotkb": "MOV10; RCJMB04_11i10", "gene_names_refseq": "MOV10", "protein_names_uniprotkb": "RNA helicase MOV-10; 5.6.2.5; RNA 5'-3' helicase MOV-10", "protein_names_refseq": "Mov10, Moloney leukemia virus 10, homolog; putative helicase MOV-10", "tax_id": 9031, "disease": "", "pathway": " (gga:419872)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720147.1, SRR13267654.200683.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000356.1. On Sep 23, 2021 this sequence version replaced NP_001012861.1., [RefSeq]; 5'-3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) (By similarity). Required for embryonic viability and for normal central nervous system development and function. May function as a messenger ribonucleoprotein (mRNP) clearance factor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0032574 5'-3' RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0035279 miRNA-mediated gene silencing by mRNA destabilization;GO:0035195 miRNA-mediated post-transcriptional gene silencing;GO:0061014 positive regulation of mRNA catabolic process;GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKD7-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKD9-1", "uniprot_id": [ { "id": "KLH20_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKD9", "type": "external" } ], "mass": 68025.0, "length": 610, "protein_name": "Kelch-like protein 20", "gene_name": "KLHL20", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KLHL20; RCJMB04_11i2", "gene_names_refseq": "", "protein_names_uniprotkb": "Kelch-like protein 20", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:425091)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0019964 type II interferon binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0016605 PML body;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0015031 protein transport;GO:0043066 negative regulation of apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006895 Golgi to endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKD9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKH4-1", "uniprot_id": [ { "id": "NDEL1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKH4", "type": "external" } ], "mass": 38230.0, "length": 343, "protein_name": "Nuclear distribution protein nudE-like 1", "gene_name": "NDEL1", "organism": "Chicken", "refseq_name": "nuclear distribution protein nudE-like 1", "refseq_ac": [ { "id": "NP_001025867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025867", "type": "external" } ], "gene_names_uniprotkb": "NDEL1; RCJMB04_10n4", "gene_names_refseq": "NDEL1", "protein_names_uniprotkb": "Nuclear distribution protein nudE-like 1", "protein_names_refseq": "nuclear distribution protein nudE-like 1; nudE nuclear distribution E homolog-like 1; nudE nuclear distribution gene E homolog like 1", "tax_id": 9031, "disease": "", "pathway": " (gga:417317)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720110.1, SRR13267656.17405.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000315.1. On Aug 8, 2005 this sequence version replaced XP_415586.1., [RefSeq]; Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule;GO:0005871 kinesin complex;GO:0000776 kinetochore", "go_biological_process": "GO:0007059 chromosome segregation;GO:0016477 cell migration;GO:0007020 microtubule nucleation;GO:0010975 regulation of neuron projection development;GO:0000132 establishment of mitotic spindle orientation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKH4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKK7-1", "uniprot_id": [ { "id": "ERCC3_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKK7", "type": "external" } ], "mass": 89680.0, "length": 788, "protein_name": "General transcription and DNA repair factor IIH helicase/translocase subunit XPB", "gene_name": "ERCC3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ERCC3; RCJMB04_10e8", "gene_names_refseq": "", "protein_names_uniprotkb": "General transcription and DNA repair factor IIH helicase/translocase subunit XPB; 5.6.2.4; DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; TFIIH subunit XPB", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-353303)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12773817;15572677;15642098;1764072", "class_list": "", "function": "ATP-dependent 3'-5' DNA helicase/translocase; binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting and twisting that allows XPD/ERCC2 helicase to anchor. The ATP-dependent helicase activity of XPB/ERCC3 may be required for promoter escape. Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.5.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005654 nucleoplasm;GO:0005675 transcription factor TFIIH holo complex;GO:0000112 nucleotide-excision repair factor 3 complex", "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5ZKK7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKM1-1", "uniprot_id": [ { "id": "SPB1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKM1", "type": "external" } ], "mass": 95006.0, "length": 832, "protein_name": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3", "gene_name": "FTSJ3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FTSJ3; RCJMB04_10b6", "gene_names_refseq": "", "protein_names_uniprotkb": "pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3; 2.1.1.-; Protein ftsJ homolog 3; Putative rRNA methyltransferase 3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:419943)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15592404;15642098", "class_list": "", "function": "RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016435 rRNA (guanine) methyltransferase activity;GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity;GO:0062105 RNA 2'-O-methyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0030687 preribosome, large subunit precursor;GO:0030688 preribosome, small subunit precursor", "go_biological_process": "GO:0031167 rRNA methylation;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0001510 RNA methylation;GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZKM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKN1-1", "uniprot_id": [ { "id": "CDK9_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKN1", "type": "external" } ], "mass": 42803.0, "length": 372, "protein_name": "Cyclin-dependent kinase 9", "gene_name": "CDK9", "organism": "Chicken", "refseq_name": "cyclin-dependent kinase 9", "refseq_ac": [ { "id": "NP_001006201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006201", "type": "external" } ], "gene_names_uniprotkb": "CDK9; RCJMB04_9p8", "gene_names_refseq": "CDK9", "protein_names_uniprotkb": "Cyclin-dependent kinase 9; 2.7.11.22; 2.7.11.23; Cell division protein kinase 9", "protein_names_refseq": "cell division protein kinase 9; cyclin-dependent kinase 9 (CDC2-related kinase); cyclin-dependent kinase 9", "tax_id": 9031, "disease": "", "pathway": " (gga:417226)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720053.1, HAEK01000819.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000308.1. On Jan 13, 2005 this sequence version replaced XP_415509.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex also has a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000307 cyclin-dependent protein kinase holoenzyme complex;GO:0070691 P-TEFb complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0120187 positive regulation of protein localization to chromatin", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKN1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKN2-1", "uniprot_id": [ { "id": "PGRC1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKN2", "type": "external" } ], "mass": 21282.0, "length": 192, "protein_name": "Membrane-associated progesterone receptor component 1", "gene_name": "PGRMC1", "organism": "Chicken", "refseq_name": "membrane-associated progesterone receptor component 1", "refseq_ac": [ { "id": "NP_001258868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258868", "type": "external" } ], "gene_names_uniprotkb": "PGRMC1; RCJMB04_7g20; RCJMB04_9p4", "gene_names_refseq": "PGRMC1; mPR", "protein_names_uniprotkb": "Membrane-associated progesterone receptor component 1; mPR", "protein_names_refseq": "membrane-associated progesterone receptor component 1", "tax_id": 9031, "disease": "", "pathway": " (gga:772196); (R-GGA-6798695)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15642098;23913445", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01061316.1, HAEL01006040.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992531, SAMEA103992639 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000071.1. On Dec 17, 2012 this sequence version replaced XP_001234322.2. Sequence Note: This RefSeq record was created from transcripts of different breeds and genomic sequence data because no single transcript from the same breed was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; Component of a progesterone-binding protein complex. Binds progesterone (By similarity). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (By similarity). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data suggest that progesterone receptors A (PRA) and B (PRB) and progesterone receptor membrane component 1 (PGRMC1) are expressed in neurons of embryonic dorsal root ganglia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZL66", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0005496 steroid binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:1903078 positive regulation of protein localization to plasma membrane;GO:0006783 heme biosynthetic process;GO:0140077 positive regulation of lipoprotein transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZKN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKP6-1", "uniprot_id": [ { "id": "ADA_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKP6", "type": "external" } ], "mass": 40679.0, "length": 357, "protein_name": "Adenosine deaminase", "gene_name": "ADA", "organism": "Chicken", "refseq_name": "adenosine deaminase", "refseq_ac": [ { "id": "NP_001006290", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006290", "type": "external" } ], "gene_names_uniprotkb": "ADA; RCJMB04_9m8", "gene_names_refseq": "ADA", "protein_names_uniprotkb": "Adenosine deaminase; 3.5.4.4; Adenosine aminohydrolase", "protein_names_refseq": "adenosine aminohydrolase; adenosine deaminase", "tax_id": 9031, "disease": "", "pathway": " (gga:419194)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15642098;23102846;26911648", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720038.1, HAEL01011899.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000328.1. On Sep 23, 2021 this sequence version replaced NP_001006290.1., [RefSeq]; ADA activity in serum was decreased of laying hens naturally infected by Salmonella Gallinarum., [RefSeq, PubMed]; According to microarray and qRT-PCR analyses, the nucleotide metabolism-related gene ADA was more highly expressed in the chicken primordial germ cells than that of stage X blastoderms., [RefSeq, PubMed]; Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" } ], "go_molecular_function": "GO:0004000 adenosine deaminase activity;GO:0008270 zinc ion binding;GO:0046936 2'-deoxyadenosine deaminase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005764 lysosome;GO:0009897 external side of plasma membrane;GO:0060205 cytoplasmic vesicle lumen;GO:0070161 anchoring junction", "go_biological_process": "GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:0006154 adenosine catabolic process;GO:0009117 nucleotide metabolic process;GO:0046103 inosine biosynthetic process;GO:0042110 T cell activation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q5ZKP6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKR7-1", "uniprot_id": [ { "id": "ACBG2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKR7", "type": "external" } ], "mass": 84207.0, "length": 763, "protein_name": "Long-chain-fatty-acid--CoA ligase ACSBG2", "gene_name": "ACSBG2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ACSBG2; RCJMB04_9i11", "gene_names_refseq": "", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase ACSBG2; 6.2.1.15; 6.2.1.3; Acyl-CoA synthetase bubblegum family member 2; Arachidonate--CoA ligase ACSBG2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Catalyzes the conversion of fatty acids such as long chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids., [UniProtKB, UniProtKB]; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKR7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKS6-1", "uniprot_id": [ { "id": "BECN1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKS6", "type": "external" } ], "mass": 51435.0, "length": 447, "protein_name": "Beclin-1", "gene_name": "BECN1", "organism": "Chicken", "refseq_name": "beclin-1", "refseq_ac": [ { "id": "NP_001006332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006332", "type": "external" } ], "gene_names_uniprotkb": "BECN1; RCJMB04_9f22", "gene_names_refseq": "BECN1; beclin-1", "protein_names_uniprotkb": "Beclin-1", "protein_names_refseq": "beclin 1 (coiled-coil, myosin-like BCL2 interacting protein); beclin 1, autophagy related; beclin-1", "tax_id": 9031, "disease": "", "pathway": " (gga:420018)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720008.1, HAEK01013090.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ720008.1. On Jan 13, 2005 this sequence version replaced XP_418139.1., [RefSeq]; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0043548 phosphatidylinositol 3-kinase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0010008 endosome membrane;GO:0005776 autophagosome", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0051301 cell division;GO:0051607 defense response to virus;GO:0045022 early endosome to late endosome transport;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKS6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKS8-1", "uniprot_id": [ { "id": "UBIA1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKS8", "type": "external" } ], "mass": 35750.0, "length": 333, "protein_name": "UbiA prenyltransferase domain-containing protein 1", "gene_name": "UBIAD1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "UBIAD1; RCJMB04_9f15", "gene_names_refseq": "", "protein_names_uniprotkb": "UbiA prenyltransferase domain-containing protein 1; 2.5.1.-; 2.5.1.39", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:419456)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione; K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0016209 antioxidant activity;GO:0004659 prenyltransferase activity;GO:0008412 4-hydroxybenzoate polyprenyltransferase activity;GO:0120566 menadiol geranylgeranyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072359 circulatory system development;GO:0006744 ubiquinone biosynthetic process;GO:0009234 menaquinone biosynthetic process;GO:0042371 vitamin K biosynthetic process;GO:0001885 endothelial cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKS8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKU5-1", "uniprot_id": [ { "id": "RAB14_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKU5", "type": "external" } ], "mass": 23897.0, "length": 215, "protein_name": "Ras-related protein Rab-14", "gene_name": "RAB14", "organism": "Chicken", "refseq_name": "ras-related protein Rab-14", "refseq_ac": [ { "id": "NP_001012814", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012814", "type": "external" } ], "gene_names_uniprotkb": "RAB14; RCJMB04_9b24", "gene_names_refseq": "RAB14", "protein_names_uniprotkb": "Ras-related protein Rab-14; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-14", "tax_id": 9031, "disease": "", "pathway": " (gga:417119)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719989.1, HAEK01095668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000308.1. On Mar 14, 2005 this sequence version replaced XP_415402.1., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB14 is involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development (By similarity). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB4B (By similarity). Interaction with RAB11FIP1 may function in the process of neurite formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0012505 endomembrane system", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042742 defense response to bacterium;GO:0006895 Golgi to endosome transport;GO:0032456 endocytic recycling;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKV8-1", "uniprot_id": [ { "id": "KIF2A_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKV8", "type": "external" } ], "mass": 79864.0, "length": 706, "protein_name": "Kinesin-like protein KIF2A", "gene_name": "KIF2A", "organism": "Chicken", "refseq_name": "kinesin-like protein KIF2A", "refseq_ac": [ { "id": "NP_001034401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034401", "type": "external" } ], "gene_names_uniprotkb": "KIF2A; RCJMB04_9a7", "gene_names_refseq": "KIF2A", "protein_names_uniprotkb": "Kinesin-like protein KIF2A", "protein_names_refseq": "kinesin-like protein KIF2A", "tax_id": 9031, "disease": "", "pathway": " (gga:427156)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719976.1, SRR13267649.292686.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000089.1. On Sep 27, 2011 this sequence version replaced NP_001034401.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005874 microtubule", "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZKV8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZKY0-1", "uniprot_id": [ { "id": "TM175_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZKY0", "type": "external" } ], "mass": 56098.0, "length": 501, "protein_name": "Endosomal/lysosomal proton channel TMEM175", "gene_name": "TMEM175", "organism": "Chicken", "refseq_name": "endosomal/lysosomal proton channel TMEM175", "refseq_ac": [ { "id": "NP_001006582", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006582", "type": "external" } ], "gene_names_uniprotkb": "TMEM175; RCJMB04_8l18", "gene_names_refseq": "TMEM175", "protein_names_uniprotkb": "Endosomal/lysosomal proton channel TMEM175; Potassium channel TMEM175; Transmembrane protein 175", "protein_names_refseq": "endosomal/lysomomal potassium channel TMEM175; endosomal/lysosomal potassium channel TMEM175; endosomal/lysosomal proton channel TMEM175", "tax_id": 9031, "disease": "", "pathway": " (gga:427293)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15592404;15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719954.1, HAEK01061182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000095.1. On Sep 23, 2021 this sequence version replaced NP_001006582.1., [RefSeq]; Proton-activated proton channel that catalyzes proton efflux from endosomes and lysosomes to maintain a steady-state pH. Activated at low pH (under pH 4.6) by luminal side protons: selectively mediates lysosomal proton release from lysosomes, eliciting a proton leak that balances V-ATPase activity to maintain pH homeostasis. Regulation of lumenal pH stability is required for autophagosome-lysosome fusion. Also acts as a potassium channel at higher pH, regulating potassium conductance in endosomes and lysosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1NKK7", "ec_number_list": [], "go_molecular_function": "GO:0022841 potassium ion leak channel activity;GO:0005267 potassium channel activity;GO:0050544 arachidonate binding;GO:0015252 proton channel activity", "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0070050 neuron cellular homeostasis;GO:0035752 lysosomal lumen pH elevation;GO:0090385 phagosome-lysosome fusion;GO:0071805 potassium ion transmembrane transport;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZKY0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZL21-1", "uniprot_id": [ { "id": "MMAC_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZL21", "type": "external" } ], "mass": 27637.0, "length": 238, "protein_name": "Cyanocobalamin reductase / alkylcobalamin dealkylase", "gene_name": "MMACHC", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MMACHC; RCJMB04_8d5", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyanocobalamin reductase / alkylcobalamin dealkylase; 1.16.1.6; 2.5.1.151; Alkylcobalamin:glutathione S-alkyltransferase; CblC; Cyanocobalamin reductase (cyanide-eliminating); MMACHC; Methylmalonic aciduria and homocystinuria type C protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:424597)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Cobalamin (vitamin B12) cytosolic chaperone that catalyzes the reductive decyanation of cyanocob(III)alamin (cyanocobalamin, CNCbl) to yield cob(II)alamin and cyanide, using FAD or FMN as cofactors and NADPH as cosubstrate. Cyanocobalamin constitutes the inactive form of vitamin B12 introduced from the diet, and is converted into the active cofactors methylcobalamin (MeCbl) involved in methionine biosynthesis, and 5'-deoxyadenosylcobalamin (AdoCbl) involved in the TCA cycle. Forms a complex with the lysosomal transporter ABCD4 and its chaperone LMBRD1, to transport cobalamin across the lysosomal membrane into the cytosol. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Also acts as a glutathione transferase by catalyzing the dealkylation of the alkylcob(III)alamins MeCbl and AdoCbl, using the thiolate of glutathione for nucleophilic displacement to generate cob(I)alamin and the corresponding glutathione thioether. The conversion of incoming MeCbl or AdoCbl into a common intermediate cob(I)alamin is necessary to meet the cellular needs for both cofactors. Cysteine and homocysteine cannot substitute for glutathione in this reaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.16.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.1.6", "type": "external" }, { "id": "2.5.1.151", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.151", "type": "external" } ], "go_molecular_function": "GO:0043295 glutathione binding;GO:0071949 FAD binding;GO:0016740 transferase activity;GO:0016491 oxidoreductase activity;GO:0032451 demethylase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0009235 cobalamin metabolic process;GO:0070988 demethylation;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZL21-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZL33-1", "uniprot_id": [ { "id": "STRAP_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZL33", "type": "external" } ], "mass": 38141.0, "length": 350, "protein_name": "Serine-threonine kinase receptor-associated protein", "gene_name": "STRAP", "organism": "Chicken", "refseq_name": "serine-threonine kinase receptor-associated protein", "refseq_ac": [ { "id": "NP_001006247", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006247", "type": "external" } ], "gene_names_uniprotkb": "STRAP; RCJMB04_7p19", "gene_names_refseq": "STRAP", "protein_names_uniprotkb": "Serine-threonine kinase receptor-associated protein", "protein_names_refseq": "serine-threonine kinase receptor-associated protein", "tax_id": 9031, "disease": "", "pathway": " (gga:418175); (R-GGA-2173788)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719901.1, HAEK01030433.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Sep 27, 2011 this sequence version replaced NP_001006247.1., [RefSeq]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005102 signaling receptor binding;GO:1990447 U2 snRNP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0032797 SMN complex;GO:0034719 SMN-Sm protein complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0030277 maintenance of gastrointestinal epithelium;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0000387 spliceosomal snRNP assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZL33-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZL34-1", "uniprot_id": [ { "id": "CPSF6_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZL34", "type": "external" } ], "mass": 59360.0, "length": 551, "protein_name": "Cleavage and polyadenylation specificity factor subunit 6", "gene_name": "CPSF6", "organism": "Chicken", "refseq_name": "cleavage and polyadenylation specificity factor subunit 6", "refseq_ac": [ { "id": "NP_001034360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034360", "type": "external" } ], "gene_names_uniprotkb": "CPSF6; RCJMB04_7p13", "gene_names_refseq": "CPSF6", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 6", "protein_names_refseq": "cleavage and polyadenylation specific factor 6, 68kDa; cleavage and polyadenylation specificity factor subunit 6", "tax_id": 9031, "disease": "", "pathway": " (gga:417844)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719900.1, SRR13267654.167708.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Mar 6, 2015 this sequence version replaced NP_001034360.1. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs. Plays a role in mRNA export., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck", "go_biological_process": "GO:0046833 positive regulation of RNA export from nucleus;GO:0051290 protein heterotetramerization;GO:0110104 mRNA alternative polyadenylation;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZL34-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZL36-1", "uniprot_id": [ { "id": "ZFY27_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZL36", "type": "external" } ], "mass": 44926.0, "length": 406, "protein_name": "Protrudin", "gene_name": "ZFYVE27", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ZFYVE27; RCJMB04_7p9", "gene_names_refseq": "", "protein_names_uniprotkb": "Protrudin; Zinc finger FYVE domain-containing protein 27", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:423839)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Molecular tethering protein, which plays a role in the formation of membrane contact sites between the endoplasmic reticulum and late endosomes/lysosomes. Promotes neurite formation by tethering endosomes to the endoplasmic reticulum membrane: interacts with Rab7-positive late endosomes, acting as a bridge to form endoplasmic reticulum membrane-endosome contact sites., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0030424 axon;GO:0030425 dendrite", "go_biological_process": "GO:0031175 neuron projection development;GO:0072659 protein localization to plasma membrane;GO:0016192 vesicle-mediated transport;GO:0045773 positive regulation of axon extension;GO:0048011 neurotrophin TRK receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZL36-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZL43-1", "uniprot_id": [ { "id": "MTND_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZL43", "type": "external" } ], "mass": 21674.0, "length": 180, "protein_name": "Acireductone dioxygenase", "gene_name": "ADI1", "organism": "Chicken", "refseq_name": "acireductone dioxygenase", "refseq_ac": [ { "id": "NP_001026260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026260", "type": "external" } ], "gene_names_uniprotkb": "ADI1; MTCBP1; RCJMB04_7o8", "gene_names_refseq": "ADI1; ARD'; Fe-ARD; MTCBP-1; MTCBP1; Ni-ARD", "protein_names_uniprotkb": "Acireductone dioxygenase; 1.13.11.53; 1.13.11.54; ARD'; ARD; Acireductone dioxygenase (Fe(2+)-requiring); Acireductone dioxygenase (Ni(2+)-requiring); Fe-ARD; MTCBP-1; Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1; Ni-ARD", "protein_names_refseq": "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; aci-reductone dioxygenase; acireductone dioxygenase (Ni(2+)-requiring); acireductone dioxygenase; fe-ARD", "tax_id": 9031, "disease": "", "pathway": " (gga:421918); (R-GGA-1237112)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01003408.1, AJ719891.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992440, SAMEA103992559 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000065.1. On Aug 8, 2005 this sequence version replaced XP_419935.1., [RefSeq]; Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.54", "type": "external" }, { "id": "1.13.11.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.53", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016151 nickel cation binding;GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity;GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine;GO:0006555 methionine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZL43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZLA6-1", "uniprot_id": [ { "id": "MYO1C_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZLA6", "type": "external" } ], "mass": 118907.0, "length": 1028, "protein_name": "Unconventional myosin-Ic", "gene_name": "MYO1C", "organism": "Chicken", "refseq_name": "unconventional myosin-Ic", "refseq_ac": [ { "id": "NP_001006220", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006220", "type": "external" } ], "gene_names_uniprotkb": "MYO1C; RCJMB04_6o17", "gene_names_refseq": "MYO1C", "protein_names_uniprotkb": "Unconventional myosin-Ic; MMI-beta; MMIb; Myosin I beta", "protein_names_refseq": "MMI-beta; MMIb; myosin I beta; unconventional myosin-Ic", "tax_id": 9031, "disease": "", "pathway": " (gga:417555)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719828.1, SRR13267655.117280.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000323.1. On Sep 23, 2021 this sequence version replaced NP_001006220.2., [RefSeq]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0015629 actin cytoskeleton;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030048 actin filament-based movement", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZLA6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZLC5-1", "uniprot_id": [ { "id": "ATPB_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZLC5", "type": "external" } ], "mass": 56628.0, "length": 533, "protein_name": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial", "gene_name": "ATP5F1B", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ATP5F1B; ATP5B; RCJMB04_6l18", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP synthase F(1) complex catalytic subunit beta, mitochondrial; 7.1.2.2; ATP synthase F1 subunit beta", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:426673)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;16287166", "class_list": "", "function": "Catalytic subunit beta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). With the subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P84168", "ec_number_list": [ { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZLC5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZLL1-1", "uniprot_id": [ { "id": "KC1E_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZLL1", "type": "external" } ], "mass": 47471.0, "length": 416, "protein_name": "Casein kinase I isoform epsilon", "gene_name": "CSNK1E", "organism": "Chicken", "refseq_name": "casein kinase I isoform epsilon", "refseq_ac": [ { "id": "NP_989708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989708", "type": "external" } ], "gene_names_uniprotkb": "CSNK1E; DBT; RCJMB04_5k10", "gene_names_refseq": "CSNK1E; DBT", "protein_names_uniprotkb": "Casein kinase I isoform epsilon; 2.7.11.1; CKI-epsilon; CKIe", "protein_names_refseq": "CKI-epsilon; CKIe; casein kinase I isoform epsilon", "tax_id": 9031, "disease": "", "pathway": " (gga:378891)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267658.23554.1, SRR13267656.17891.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Mar 5, 2015 this sequence version replaced NP_989708.2. The protein encoded by this gene is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. [provided by RefSeq, Feb 2014]., [RefSeq]; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q7T1G2;Q7T3L8", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0006897 endocytosis;GO:0007165 signal transduction;GO:0048511 rhythmic process;GO:0090263 positive regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZLL1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZLM0-1", "uniprot_id": [ { "id": "CDC73_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZLM0", "type": "external" } ], "mass": 60698.0, "length": 531, "protein_name": "Parafibromin", "gene_name": "CDC73", "organism": "Chicken", "refseq_name": "parafibromin", "refseq_ac": [ { "id": "NP_001026436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026436", "type": "external" } ], "gene_names_uniprotkb": "CDC73; RCJMB04_5j4", "gene_names_refseq": "CDC73", "protein_names_uniprotkb": "Parafibromin; Cell division cycle protein 73 homolog", "protein_names_refseq": "cell division cycle 73, Paf1/RNA polymerase II complex component, homolog; cell division cycle protein 73 homolog; parafibromin", "tax_id": 9031, "disease": "", "pathway": " (gga:424356)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719714.1, SRR13267658.720.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000237.1. On Aug 8, 2005 this sequence version replaced XP_422199.1., [RefSeq]; Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0019827 stem cell population maintenance;GO:0006368 transcription elongation by RNA polymerase II;GO:2000134 negative regulation of G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZLM0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZLN4-1", "uniprot_id": [ { "id": "FEN1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZLN4", "type": "external" } ], "mass": 42983.0, "length": 381, "protein_name": "Flap endonuclease 1", "gene_name": "FEN1", "organism": "Chicken", "refseq_name": "flap endonuclease 1", "refseq_ac": [ { "id": "NP_001072959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072959", "type": "external" } ], "gene_names_uniprotkb": "FEN1; RCJMB04_5g12", "gene_names_refseq": "FEN-1; FEN1", "protein_names_uniprotkb": "Flap endonuclease 1; 3.1.-.-; FEN-1; Flap structure-specific endonuclease 1", "protein_names_refseq": "FEN-1 nuclease; flap endonuclease 1", "tax_id": 9031, "disease": "", "pathway": " (gga:769677); (R-GGA-110362); (R-GGA-174437); (R-GGA-5651801); (R-GGA-5685939); (R-GGA-69166)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "12136109;15642098;16055708;20145043", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719700.1, AJ445675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ719700.1. On Dec 9, 2006 this sequence version replaced XP_001231721.1., [RefSeq]; Fen-1 eliminates heterologous sequences at DNA damage site and facilitates DNA repair by homologous recombination, [RefSeq, PubMed]; Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA., [UniProtKB, HAMAP]; These results illustrate that FEN1 plays a role in LP-BER in higher eukaryotes, presumably by processing the flap-containing intermediates of BER., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90YB0", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0030145 manganese ion binding;GO:0004523 RNA-DNA hybrid ribonuclease activity;GO:0008409 5'-3' exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006284 base-excision repair;GO:0043137 DNA replication, removal of RNA primer;GO:0045876 positive regulation of sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5ZLN4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZLP8-1", "uniprot_id": [ { "id": "IF2B3_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZLP8", "type": "external" } ], "mass": 64373.0, "length": 584, "protein_name": "Insulin-like growth factor 2 mRNA-binding protein 3", "gene_name": "IGF2BP3", "organism": "Chicken", "refseq_name": "insulin-like growth factor 2 mRNA-binding protein 3", "refseq_ac": [ { "id": "NP_001006359", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006359", "type": "external" } ], "gene_names_uniprotkb": "IGF2BP3; RCJMB04_5e15; VICKZ3", "gene_names_refseq": "IGF2BP3; VICKZ3", "protein_names_uniprotkb": "Insulin-like growth factor 2 mRNA-binding protein 3; IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; VICKZ family member 3", "protein_names_refseq": "IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; VICKZ family member 3; insulin-like growth factor 2 mRNA-binding protein 3", "tax_id": 9031, "disease": "", "pathway": " (gga:420617)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15601260;15642098;28111433;32121275", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719686.1, SRR13267661.18636.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ719686.1. On Jan 13, 2005 this sequence version replaced XP_418716.1., [RefSeq]; MiR-9-5p Inhibits Skeletal Muscle Satellite Cell Proliferation and Differentiation by Targeting IGF2BP3 through the IGF2-PI3K/Akt Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability., [UniProtKB, UniProtKB]; Real-time qPCR results revealed that the downregulation of chicken miRNA gga-let-7d in the intestinal mucosal layer of Necrotic enteritis induced Fayoumi chicken line M15.2 was associated with the upregulation of its top-ranking target gene IGF2BP3., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:0006417 regulation of translation;GO:0007399 nervous system development;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q5ZLP8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZLS7-1", "uniprot_id": [ { "id": "GLYR1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZLS7", "type": "external" } ], "mass": 60601.0, "length": 553, "protein_name": "Cytokine-like nuclear factor N-PAC", "gene_name": "GLYR1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GLYR1; NP60; RCJMB04_4p18", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytokine-like nuclear factor N-PAC; Glyoxylate reductase 1 homolog; NPAC; Nuclear protein NP60; Putative oxidoreductase GLYR1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:426988)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression. Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA. Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0051287 NAD binding;GO:0031491 nucleosome binding;GO:0050661 NADP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0140673 transcription elongation-coupled chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZLS7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZLX2-1", "uniprot_id": [ { "id": "IF2A_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZLX2", "type": "external" } ], "mass": 36178.0, "length": 315, "protein_name": "Eukaryotic translation initiation factor 2 subunit 1", "gene_name": "EIF2S1", "organism": "Chicken", "refseq_name": "eukaryotic translation initiation factor 2 subunit 1", "refseq_ac": [ { "id": "NP_001384104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001384104", "type": "external" } ], "gene_names_uniprotkb": "EIF2S1; EIF2A; RCJMB04_4i21", "gene_names_refseq": "EIF2A; EIF2S1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha; eIF2-alpha", "protein_names_refseq": "eIF-2-alpha; eIF-2A; eIF-2alpha; eIF2-alpha; eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa", "tax_id": 9031, "disease": "", "pathway": " (gga:423279); (R-GGA-381042); (R-GGA-72649); (R-GGA-72695); (R-GGA-72702); (R-GGA-72731); (R-GGA-9840373)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "12445392;15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01010541.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1., [RefSeq]; Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B. EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule;GO:0033290 eukaryotic 48S preinitiation complex;GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:0006413 translational initiation;GO:0036499 PERK-mediated unfolded protein response;GO:0034976 response to endoplasmic reticulum stress;GO:0034198 cellular response to amino acid starvation;GO:0034644 cellular response to UV", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZLX2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZM57-1", "uniprot_id": [ { "id": "HACD3_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZM57", "type": "external" } ], "mass": 42835.0, "length": 362, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase", "gene_name": "HACD3", "organism": "Chicken", "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase", "refseq_ac": [ { "id": "NP_001007829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007829", "type": "external" } ], "gene_names_uniprotkb": "HACD3; PTPLAD1; RCJMB04_3b6", "gene_names_refseq": "B-IND1; HACD3; HACD; PTPLAD1", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; 3-hydroxyacyl-CoA dehydratase; 4.2.1.134; HACD; Protein-tyrosine phosphatase-like A domain-containing protein 1", "protein_names_refseq": "butyrate-induced transcript 1; protein tyrosine phosphatase-like A domain containing 1; protein tyrosine phosphatase-like protein PTPLAD1; protein-tyrosine phosphatase-like A domain-containing protein 1; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase", "tax_id": 9031, "disease": "", "pathway": " (gga:415539)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719527.1, SRR13267649.253291.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000246.1. On Dec 15, 2004 this sequence version replaced XP_413908.1., [RefSeq]; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Involved in Rac1-signaling pathways leading to the modulation of gene expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.134", "type": "external" } ], "go_molecular_function": "GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZM57-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZM98-1", "uniprot_id": [ { "id": "HSPA9_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZM98", "type": "external" } ], "mass": 73192.0, "length": 675, "protein_name": "Stress-70 protein, mitochondrial", "gene_name": "HSPA9", "organism": "Chicken", "refseq_name": "stress-70 protein, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001006147", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006147", "type": "external" } ], "gene_names_uniprotkb": "HSPA9; RCJMB04_2m8", "gene_names_refseq": "HSPA9B; HSPA9", "protein_names_uniprotkb": "Stress-70 protein, mitochondrial; 3.6.4.10; 75 kDa glucose-regulated protein; GRP-75; Heat shock 70 kDa protein 9", "protein_names_refseq": "75 kDa glucose-regulated protein; GRP-75; heat shock 70 kDa protein 9; heat shock 70kDa protein 9 (mortalin); stress-70 protein, mitochondrial precursor; stress-70 protein, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (gga:416183)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;16287166", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719486.1, SRR13267653.29560.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000256.1. On Sep 23, 2021 this sequence version replaced NP_001006147.1., [RefSeq]; Mitochondrial chaperone that plays a key role in mitochondrial protein import, folding, and assembly. Plays an essential role in the protein quality control system, the correct folding of proteins, the re-folding of misfolded proteins, and the targeting of proteins for subsequent degradation. These processes are achieved through cycles of ATP binding, ATP hydrolysis, and ADP release, mediated by co-chaperones. In mitochondria, it associates with the TIM (translocase of the inner membrane) protein complex to assist in the import and folding of mitochondrial proteins (By similarity). Plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis, interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. Regulates mitochondrial calcium-dependent apoptosis by coupling two calcium channels, ITPR1 and VDAC1, at the mitochondria-associated endoplasmic reticulum (ER) membrane to facilitate calcium transport from the ER lumen to the mitochondria intermembrane space, providing calcium for the downstream calcium channel MCU, which releases it into the mitochondrial matrix (By similarity). Although primarily located in the mitochondria, it is also found in other cellular compartments. In the cytosol, it associates with proteins involved in signaling, apoptosis, or senescence. It may play a role in cell cycle regulation via its interaction with and promotion of degradation of TP53 (By similarity). May play a role in the control of cell proliferation and cellular aging (By similarity). Protects against reactive oxygen species (ROS) (By similarity). Extracellular HSPA9 plays a cytoprotective role by preventing cell lysis following immune attack by the membrane attack complex by disrupting formation of the complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P84163", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:1902037 negative regulation of hematopoietic stem cell differentiation;GO:0030218 erythrocyte differentiation;GO:0042026 protein refolding;GO:0045646 regulation of erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZM98-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZMA2-1", "uniprot_id": [ { "id": "PRP19_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZMA2", "type": "external" } ], "mass": 55135.0, "length": 505, "protein_name": "Pre-mRNA-processing factor 19", "gene_name": "PRPF19", "organism": "Chicken", "refseq_name": "pre-mRNA-processing factor 19", "refseq_ac": [ { "id": "NP_001034420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034420", "type": "external" } ], "gene_names_uniprotkb": "PRPF19; RCJMB04_2m2", "gene_names_refseq": "PRPF19", "protein_names_uniprotkb": "Pre-mRNA-processing factor 19; 2.3.2.27; PRP19/PSO4 homolog; RING-type E3 ubiquitin transferase PRP19", "protein_names_refseq": "PRP19/PSO4 homolog; PRP19/PSO4 pre-mRNA processing factor 19 homolog; RING-type E3 ubiquitin transferase PRP19; pre-mRNA-processing factor 19", "tax_id": 9031, "disease": "", "pathway": " (gga:430767)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;16287166", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.66203.1, SRR13267654.71413.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000212.1. On Sep 23, 2021 this sequence version replaced NP_001034420.2., [RefSeq]; Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P84167", "ec_number_list": [], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005819 spindle", "go_biological_process": "GO:0006281 DNA repair;GO:0000398 mRNA splicing, via spliceosome;GO:0070534 protein K63-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZMA2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZMC2-1", "uniprot_id": [ { "id": "MYO1G_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZMC2", "type": "external" } ], "mass": 114970.0, "length": 1007, "protein_name": "Unconventional myosin-Ig", "gene_name": "MYO1G", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MYO1G; RCJMB04_2i22", "gene_names_refseq": "", "protein_names_uniprotkb": "Unconventional myosin-Ig", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:420412)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005902 microvillus", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030048 actin filament-based movement;GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0072678 T cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZMC2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZMG1-1", "uniprot_id": [ { "id": "UFL1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZMG1", "type": "external" } ], "mass": 89104.0, "length": 789, "protein_name": "E3 UFM1-protein ligase 1", "gene_name": "UFL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "UFL1; RCJMB04_2c12", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 UFM1-protein ligase 1; 2.3.2.-; E3 UFM1-protein transferase 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy). As part of the UREL complex, plays a key role in ribosome recycling by catalyzing mono-ufmylation of RPL26/uL24 subunit of the 60S ribosome. Ufmylation of RPL26/uL24 occurs on free 60S ribosomes following ribosome dissociation: it weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane. Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum. Involved in reticulophagy in response to endoplasmic reticulum stress by mediating ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins. Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071568 UFM1 transferase activity;GO:0061666 UFM1 ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0006281 DNA repair;GO:0060218 hematopoietic stem cell differentiation;GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZMG1-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZMH1-1", "uniprot_id": [ { "id": "SEPT2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZMH1", "type": "external" } ], "mass": 40225.0, "length": 349, "protein_name": "Septin-2", "gene_name": "SEPTIN2", "organism": "Chicken", "refseq_name": "septin-2", "refseq_ac": [ { "id": "NP_001006182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006182", "type": "external" } ], "gene_names_uniprotkb": "SEPTIN2; RCJMB04_2a21; SEPT2", "gene_names_refseq": "SEPT2L; SEPT2; SEPTIN2L; SEPTIN2", "protein_names_uniprotkb": "Septin-2", "protein_names_refseq": "septin-2", "tax_id": 9031, "disease": "", "pathway": " (gga:416777)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719413.1, HAEK01006246.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ719413.1. On Jan 13, 2005 this sequence version replaced XP_415071.1., [RefSeq]; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005940 septin ring;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0015630 microtubule cytoskeleton;GO:0032154 cleavage furrow", "go_biological_process": "GO:0060271 cilium assembly;GO:0008104 intracellular protein localization;GO:0007224 smoothened signaling pathway;GO:0061640 cytoskeleton-dependent cytokinesis;GO:0017157 regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZMH1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZML0-1", "uniprot_id": [ { "id": "BABA2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZML0", "type": "external" } ], "mass": 43430.0, "length": 383, "protein_name": "BRISC and BRCA1-A complex member 2", "gene_name": "BABAM2", "organism": "Chicken", "refseq_name": "BRISC and BRCA1-A complex member 2", "refseq_ac": [ { "id": "NP_001008458", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008458", "type": "external" } ], "gene_names_uniprotkb": "BABAM2; BRE; RCJMB04_1l17", "gene_names_refseq": "BABAM2; BRE", "protein_names_uniprotkb": "BRISC and BRCA1-A complex member 2; BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein", "protein_names_refseq": "BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; BRISC and BRCA1 A complex member 2; BRISC and BRCA1-A complex member 2; brain and reproductive organ-expressed protein", "tax_id": 9031, "disease": "", "pathway": " (gga:421417)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;25568339", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719374.1, SRR13267654.122831.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000063.1. On Dec 16, 2004 this sequence version replaced XP_419470.1., [RefSeq]; Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF signaling through its interactions with TNFRSF1A; however these effects may be indirect., [UniProtKB, UniProtKB]; Increased or decreased BRE expression affects somitogenesis, neurogenesis, and NCC migration during early chick embryo development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070552 BRISC complex;GO:0070531 BRCA1-A complex", "go_biological_process": "GO:0051301 cell division;GO:0006915 apoptotic process;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZML0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZMM1-1", "uniprot_id": [ { "id": "RIOX1_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZMM1", "type": "external" } ], "mass": 65685.0, "length": 601, "protein_name": "Ribosomal oxygenase 1", "gene_name": "RIOX1", "organism": "Chicken", "refseq_name": "ribosomal oxygenase 1", "refseq_ac": [ { "id": "NP_001026367", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026367", "type": "external" } ], "gene_names_uniprotkb": "RIOX1; NO66; RCJMB04_1k4", "gene_names_refseq": "C14orf169; C5H14ORF169; NO66; RIOX1", "protein_names_uniprotkb": "Ribosomal oxygenase 1; 1.14.11.27; 1.14.11.79; Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; Histone lysine demethylase NO66", "protein_names_refseq": "bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66; histone lysine demethylase NO66; lysine-specific demethylase NO66; nucleolar protein 66; ribosomal oxygenase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:423249); (R-GGA-9629569)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: AJ719363.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ719363.1. On Aug 8, 2005 this sequence version replaced XP_430035.1., [RefSeq]; Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase (By similarity). Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4' (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes demethylation of non-histone proteins (By similarity). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on 'His-216', thereby playing a role in ribosome biogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.79", "type": "external" } ], "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0034647 histone H3K4me/H3K4me2/H3K4me3 demethylase activity;GO:0032453 histone H3K4 demethylase activity;GO:0005506 iron ion binding;GO:0016706 2-oxoglutarate-dependent dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0045668 negative regulation of osteoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZMM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZMN2-1", "uniprot_id": [ { "id": "MCM3_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZMN2", "type": "external" } ], "mass": 91251.0, "length": 812, "protein_name": "DNA replication licensing factor MCM3", "gene_name": "MCM3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MCM3; RCJMB04_1j4", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA replication licensing factor MCM3; 3.6.4.12", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:422043)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0042555 MCM complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006271 DNA strand elongation involved in DNA replication;GO:1902975 mitotic DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZMN2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZMQ9-1", "uniprot_id": [ { "id": "PEX5_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZMQ9", "type": "external" } ], "mass": 71791.0, "length": 645, "protein_name": "Peroxisomal targeting signal 1 receptor", "gene_name": "PEX5", "organism": "Chicken", "refseq_name": "peroxisomal targeting signal 1 receptor", "refseq_ac": [ { "id": "NP_001012836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012836", "type": "external" } ], "gene_names_uniprotkb": "PEX5; RCJMB04_1g17", "gene_names_refseq": "PEX5", "protein_names_uniprotkb": "Peroxisomal targeting signal 1 receptor; PTS1 receptor; PTS1-BP; PTS1R; Peroxin-5; Peroxisomal C-terminal targeting signal import receptor; Peroxisome receptor 1", "protein_names_refseq": "PTS1 receptor; PTS1-BP; PTS1R; peroxin-5; peroxisomal C-terminal targeting signal import receptor; peroxisomal targeting signal 1 receptor; peroxisome receptor 1", "tax_id": 9031, "disease": "", "pathway": " (gga:418299)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719325.1, SRR13267659.158922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AJ448622.1, CO422287.1, CR406127.1, AM063666.1, BU288967.1, JAENSK010000015.1, AJ719325.1, HAEK01028814.1, HAEK01074977.1, AJ741817.1 and AJ741816.1. On Nov 24, 2021 this sequence version replaced NP_001012836.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5., [UniProtKB, UniProtKB]; Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005052 peroxisome matrix targeting signal-1 binding;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix;GO:0005829 cytosol", "go_biological_process": "GO:0044721 protein import into peroxisome matrix, substrate release;GO:0016558 protein import into peroxisome matrix;GO:0016560 protein import into peroxisome matrix, docking;GO:0000425 pexophagy;GO:0016562 protein import into peroxisome matrix, receptor recycling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZMQ9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZMS2-1", "uniprot_id": [ { "id": "PA1B2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZMS2", "type": "external" } ], "mass": 25567.0, "length": 229, "protein_name": "Platelet-activating factor acetylhydrolase IB subunit alpha2", "gene_name": "PAFAH1B2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PAFAH1B2; PAFAHB; RCJMB04_1f10", "gene_names_refseq": "", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase IB subunit alpha2; 3.1.1.47; PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH subunit beta", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "Alpha2 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" } ], "go_molecular_function": "GO:0047179 platelet-activating factor acetyltransferase activity;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0016042 lipid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZMS2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZMS3-1", "uniprot_id": [ { "id": "IF2G_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZMS3", "type": "external" } ], "mass": 51076.0, "length": 472, "protein_name": "Eukaryotic translation initiation factor 2 subunit 3", "gene_name": "EIF2S3", "organism": "Chicken", "refseq_name": "eukaryotic translation initiation factor 2 subunit 3", "refseq_ac": [ { "id": "NP_001006260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006260", "type": "external" } ], "gene_names_uniprotkb": "EIF2S3; RCJMB04_1f8", "gene_names_refseq": "EIF2S3L; EIF2S3", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 3; 3.6.5.3; Eukaryotic translation initiation factor 2 subunit gamma; eIF2-gamma", "protein_names_refseq": "Putative eukaryotic translation initiation factor 2 subunit 3-like protein; eIF-2-gamma; eIF2-gamma; eukaryotic translation initiation factor 2 subunit 3; eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa", "tax_id": 9031, "disease": "", "pathway": " (gga:418597)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;17187762", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01000166.1, HAEL01003082.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000021.1. On Sep 23, 2021 this sequence version replaced NP_001006260.1., [RefSeq]; Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity)., [UniProtKB, UniProtKB]; We found eukaryotic elongation factor-2 (eEF2), a key component of mRNA translation, in growth cones by immunocytochemistry., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003743 translation initiation factor activity;GO:1990856 methionyl-initiator methionine tRNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005850 eukaryotic translation initiation factor 2 complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0001731 formation of translation preinitiation complex", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZMS3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZMV9-1", "uniprot_id": [ { "id": "WDR24_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZMV9", "type": "external" } ], "mass": 80210.0, "length": 705, "protein_name": "GATOR2 complex protein WDR24", "gene_name": "WDR24", "organism": "Chicken", "refseq_name": "GATOR2 complex protein WDR24", "refseq_ac": [ { "id": "NP_001025799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025799", "type": "external" } ], "gene_names_uniprotkb": "WDR24; RCJMB04_1a19", "gene_names_refseq": "WDR24", "protein_names_uniprotkb": "GATOR2 complex protein WDR24; 2.3.2.27", "protein_names_refseq": "GATOR complex protein WDR24; GATOR2 complex protein WDR24; WD repeat-containing protein 24", "tax_id": 9031, "disease": "", "pathway": " (gga:416406)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;31980681", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719275.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000257.1. On Aug 8, 2005 this sequence version replaced XP_414721.1., [RefSeq]; CREBBP and WDR 24 Identified as Candidate Genes for Quantitative Variation in Red-Brown Plumage Colouration in the Chicken. Publication Status: Online-Only, [RefSeq, PubMed]; Catalytic component of the GATOR2 complex, a multiprotein complex that acts as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. In addition to its role in regulation of the mTORC1 complex, promotes the acidification of lysosomes and facilitates autophagic flux. Within the GATOR2 complex, WDR24 constitutes the catalytic subunit that mediates 'Lys-6'-linked ubiquitination of NPRL2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0005774 vacuolar membrane;GO:0061700 GATOR2 complex", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0006914 autophagy;GO:0031669 cellular response to nutrient levels;GO:0016239 positive regulation of macroautophagy;GO:0034198 cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5ZMV9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q66PG4-1", "uniprot_id": [ { "id": "LARG2_CHICK", "url": "https://www.uniprot.org/uniprot/Q66PG4", "type": "external" } ], "mass": 85568.0, "length": 739, "protein_name": "Xylosyl- and glucuronyltransferase LARGE2s", "gene_name": "LARGE2", "organism": "Chicken", "refseq_name": "xylosyl- and glucuronyltransferase LARGE2s", "refseq_ac": [ { "id": "NP_001004404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004404", "type": "external" } ], "gene_names_uniprotkb": "LARGE2; GYLTL1B", "gene_names_refseq": "GYLTL1B; LARGE2; LARGE", "protein_names_uniprotkb": "Xylosyl- and glucuronyltransferase LARGE2s; 2.4.-.-; Glycosyltransferase-like 1B; LARGE xylosyl- and glucuronyltransferase 2", "protein_names_refseq": "acetylglucosaminyltransferase-like 1A; acetylglucosaminyltransferase-like protein; glycosyltransferase-like 1A; glycosyltransferase-like 1B; glycosyltransferase-like protein LARGE1; glycosyltransferase-like protein LARGE2; like-glycosyltransferase; xylosyl- and glucuronyltransferase LARGE2s", "tax_id": 9031, "disease": "", "pathway": " (gga:423200)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15958417", "class_list": "glycogene;glycosyltransferase", "function": "##Evidence-Data-START## Transcript exon combination :: AY662336.1, SRR13267658.21745.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY662336.1. On Sep 17, 2004 this sequence version replaced XP_421124.1., [RefSeq]; Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity). Supports the maturation of DAG1 more effectively than LARGE1 (By similarity). In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0042285 xylosyltransferase activity;GO:0046872 metal ion binding;GO:0015020 glucuronosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q66PG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6B3N0-1", "uniprot_id": [ { "id": "HXA5_CHICK", "url": "https://www.uniprot.org/uniprot/Q6B3N0", "type": "external" } ], "mass": 29742.0, "length": 270, "protein_name": "Homeobox protein Hox-A5", "gene_name": "HOXA5", "organism": "Chicken", "refseq_name": "homeobox protein Hox-A5", "refseq_ac": [ { "id": "NP_001305348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305348", "type": "external" } ], "gene_names_uniprotkb": "HOXA5", "gene_names_refseq": "HOX1.3; HOX1C; HOXA5", "protein_names_uniprotkb": "Homeobox protein Hox-A5", "protein_names_refseq": "homeo box 1C; homeo box A5; homeobox protein HOXA5; homeobox protein Hox-1C; homeobox protein Hox-A5", "tax_id": 9031, "disease": "", "pathway": " (gga:100858404)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "23462683", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY686640.1, HAEL01011593.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000037.1. On Jan 6, 2016 this sequence version replaced XP_003640747.1., [RefSeq]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' (By similarity)., [UniProtKB]; The role of Hoxa-5 in after somite segmentation in chick, was investigated., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0043065 positive regulation of apoptotic process;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6B3N0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6EE31-1", "uniprot_id": [ { "id": "TCPQ_CHICK", "url": "https://www.uniprot.org/uniprot/Q6EE31", "type": "external" } ], "mass": 59485.0, "length": 548, "protein_name": "T-complex protein 1 subunit theta", "gene_name": "CCT8", "organism": "Chicken", "refseq_name": "T-complex protein 1 subunit theta", "refseq_ac": [ { "id": "NP_001004389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004389", "type": "external" } ], "gene_names_uniprotkb": "CCT8", "gene_names_refseq": "CCT8", "protein_names_uniprotkb": "T-complex protein 1 subunit theta; 3.6.1.-; CCT-theta; TCP-1-theta", "protein_names_refseq": "CCT-theta; T-complex protein 1 subunit theta; TCP-1-theta; chaperonin containing TCP1, subunit 8 (theta); chaperonin subunit 8 theta", "tax_id": 9031, "disease": "", "pathway": " (gga:418486)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15128875;16287166", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01067528.1, HAEL01006484.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000020.1. On Jul 10, 2015 this sequence version replaced NP_001004389.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone", "go_cellular_component": "GO:0005813 centrosome;GO:0005832 chaperonin-containing T-complex", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q6EE31-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6GXJ1-1", "uniprot_id": [ { "id": "GLL4_CHICK", "url": "https://www.uniprot.org/uniprot/Q6GXJ1", "type": "external" } ], "mass": 7163.0, "length": 63, "protein_name": "Gallinacin-4", "gene_name": "GAL4", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GAL4", "gene_names_refseq": "", "protein_names_uniprotkb": "Gallinacin-4; Beta-defensin 4; Gal-4; Gal-7; Gallinacin-7", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:414342)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15148642;15310403;17244739;17346671", "class_list": "", "function": "Has bactericidal activity. Potent activity against S.typhimurium and S.entiriditis., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0PXU4;Q6QLR0", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium;GO:0050832 defense response to fungus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6GXJ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IV18-1", "uniprot_id": [ { "id": "GLL13_CHICK", "url": "https://www.uniprot.org/uniprot/Q6IV18", "type": "external" } ], "mass": 9997.0, "length": 89, "protein_name": "Gallinacin-13", "gene_name": "GAL13", "organism": "Chicken", "refseq_name": "gallinacin-13 precursor", "refseq_ac": [ { "id": "NP_001001780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001780", "type": "external" } ], "gene_names_uniprotkb": "GAL13", "gene_names_refseq": "AvBD13; GAL13; Gal-11; Gal11; gal-13", "protein_names_uniprotkb": "Gallinacin-13; Beta-defensin 13; Gal-11; Gal-13; Gallinacin-11", "protein_names_refseq": "beta-defensin 13; gallinacin-11; gallinacin-13 precursor; gallinacin-13", "tax_id": 9031, "disease": "", "pathway": " (gga:414877)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15310403;15744537;17244739;19695713", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY621315.1 [ECO:0000332] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000070.1 and AY621315.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Beta-defensin 13 can activate NH-kappaB, induce the inflammatory cytokines IL-12 and IFN-alpha, and up-regulate CD80 and monocyte proliferation., [RefSeq, PubMed]; Has bactericidal activity., [UniProtKB]; Has bactericidal activity. Potent activity against E.coli, L.monocytogenes, S.typhimurium and S.pyogenes but mot against S.aureus., [UniProtKB, PubMed]; The chicken genome encodes only beta-defensins. The 13 chicken beta-defensin genes are clustered densely within a 86-Kb distance on the chromosome 3q3.5-q3.7. The deduced peptides share the characteristic defensin motif. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q66VU2", "ec_number_list": [], "go_molecular_function": "GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002227 innate immune response in mucosa", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6IV18-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6IVA4-1", "uniprot_id": [ { "id": "UBA5_CHICK", "url": "https://www.uniprot.org/uniprot/Q6IVA4", "type": "external" } ], "mass": 44178.0, "length": 397, "protein_name": "Ubiquitin-like modifier-activating enzyme 5", "gene_name": "UBA5", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "UBA5; UBAL", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin-like modifier-activating enzyme 5; UFM1-activating enzyme; Ubiquitin activating enzyme-like protein; Ubiquitin-activating enzyme 5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:414879)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E1-like enzyme which specifically catalyzes the first step in ufmylation. Activates UFM1 by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a UFM1-E1 thioester and free AMP. Activates UFM1 via a trans-binding mechanism, in which UFM1 interacts with distinct sites in both subunits of the UBA5 homodimer. Trans-binding also promotes stabilization of the UBA5 homodimer, and enhances ATP-binding. Transfer of UFM1 from UBA5 to the E2-like enzyme UFC1 also takes place using a trans mechanism. Ufmylation plays a key role in various processes, such as ribosome recycling, response to DNA damage, interferon response or reticulophagy (also called ER-phagy)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0071566 UFM1 activating enzyme activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0030218 erythrocyte differentiation;GO:0034976 response to endoplasmic reticulum stress;GO:0071569 protein ufmylation;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6IVA4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QLR1-1", "uniprot_id": [ { "id": "GLL9_CHICK", "url": "https://www.uniprot.org/uniprot/Q6QLR1", "type": "external" } ], "mass": 7279.0, "length": 67, "protein_name": "Gallinacin-9", "gene_name": "GAL9", "organism": "Chicken", "refseq_name": "gallinacin-9 preproprotein", "refseq_ac": [ { "id": "NP_001001611", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001611", "type": "external" } ], "gene_names_uniprotkb": "GAL9", "gene_names_refseq": "AvBD9; BD-9; GAL9; Gal-6; Gal6; gal-9", "protein_names_uniprotkb": "Gallinacin-9; Beta-defensin 9; Gal-6; Gal-9; Gallinacin-6", "protein_names_refseq": "Gal 9; beta-defensin 9; gallinacin-6; gallinacin-9 preproprotein; gallinacin-9", "tax_id": 9031, "disease": "", "pathway": " (gga:414343); (R-GGA-1461957); (R-GGA-1461973)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15148642;15310403;17194828;17244739", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY621311.1, BG712665.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992428 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000070.1., [RefSeq]; Has bactericidal activity. Potent activity against C.jejuni, C.perfringens, S.aureus, C.albicans and S.cerevisiae. Less potent against S.typhimurium and E.coli., [UniProtKB, PubMed]; The chicken genome encodes only beta-defensins. The 13 chicken beta-defensin genes are clustered densely within a 86-Kb distance on the chromosome 3q3.5-q3.7. The deduced peptides share the characteristic defensin motif. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q09MS3", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium;GO:0031640 killing of cells of another organism;GO:0050832 defense response to fungus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q6QLR1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6QLR2-1", "uniprot_id": [ { "id": "GLL7_CHICK", "url": "https://www.uniprot.org/uniprot/Q6QLR2", "type": "external" } ], "mass": 7563.0, "length": 67, "protein_name": "Gallinacin-7", "gene_name": "GAL7", "organism": "Chicken", "refseq_name": "gallinacin-7 preproprotein", "refseq_ac": [ { "id": "NP_001001194", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001194", "type": "external" } ], "gene_names_uniprotkb": "GAL7", "gene_names_refseq": "AvBD7; BD7; GAL7; Gal-5; Gal5", "protein_names_uniprotkb": "Gallinacin-7; Beta-defensin 7; Gal 7; Gal-5; Gallinacin-5", "protein_names_refseq": "Gal 7; beta-defensin 7 antimicrobial peptide; beta-defensin 7 preproprotein; gallinacin-5; gallinacin-7 preproprotein; gallinacin-7", "tax_id": 9031, "disease": "", "pathway": " (gga:407777)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "15148642;15310403;17244739", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY621309.1, FJ882407.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992527 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY621309.1., [RefSeq]; Has bactericidal activity., [UniProtKB]; The chicken genome encodes only beta-defensins. The 13 chicken beta-defensin genes are clustered densely within a 86-Kb distance on the chromosome 3q3.5-q3.7. The deduced peptides share the characteristic defensin motif. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q09MR1;Q09MV1", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0031731 CCR6 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:0060326 cell chemotaxis;GO:0042742 defense response to bacterium", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q6QLR2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6U7I1-1", "uniprot_id": [ { "id": "UBP7_CHICK", "url": "https://www.uniprot.org/uniprot/Q6U7I1", "type": "external" } ], "mass": 128297.0, "length": 1101, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 7", "gene_name": "USP7", "organism": "Chicken", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 7 isoform 2", "refseq_ac": [ { "id": "NP_001334941", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334941", "type": "external" } ], "gene_names_uniprotkb": "USP7", "gene_names_refseq": "UBP; USP7", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 7; 3.4.19.12; Deubiquitinating enzyme 7; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7", "protein_names_refseq": "deubiquitinating enzyme 7; ubiquitin carboxyl-terminal hydrolase 7 isoform 2; ubiquitin carboxyl-terminal hydrolase 7; ubiquitin specific peptidase 7 (herpes virus-associated); ubiquitin specific protease 7; ubiquitin thioesterase 7; ubiquitin-specific-processing protease 7", "tax_id": 9031, "disease": "", "pathway": " (gga:395126)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY376870.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. Transcript Variant: This variant (2) differs in the 3' coding region and contains a distinct 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Hydrolase that deubiquitinates target proteins, such as p53/TP53. Deubiquitinates p53/TP53, and thereby modulates p53/TP53 stability, p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development (By similarity). Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6U7I2;Q6U7I3", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016605 PML body;GO:0005694 chromosome", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q6U7I1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6VYA3-1", "uniprot_id": [ { "id": "SOSD1_CHICK", "url": "https://www.uniprot.org/uniprot/Q6VYA3", "type": "external" } ], "mass": 23144.0, "length": 206, "protein_name": "Sclerostin domain-containing protein 1", "gene_name": "SOSTDC1", "organism": "Chicken", "refseq_name": "sclerostin domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_989704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989704", "type": "external" } ], "gene_names_uniprotkb": "SOSTDC1; WISE", "gene_names_refseq": "SOSTDC1; WISE", "protein_names_uniprotkb": "Sclerostin domain-containing protein 1; Wnt-signaling modulator", "protein_names_refseq": "context-dependent activator and inhibitor of Wnt signalling protein Wise; sclerostin domain-containing protein 1 precursor; sclerostin domain-containing protein 1; wnt-signaling modulator", "tax_id": 9031, "disease": "", "pathway": " (gga:378800)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12900447;17654720;17765217;18538759;32779697", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01001926.1, HAEK01071785.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02738218, SAMN02738220 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000036.1. On Sep 23, 2021 this sequence version replaced NP_989704.1., [RefSeq]; Can activate or inhibit Wnt signaling in a context-dependent manner. Activates the canonical Wnt pathway whereby acts through Disheveled proteins and beta-catenin. Antagonises Wnt signaling through the canonical pathways presumably by blocking accessibility of certain WNTs to their receptors. Induces posterior neural markers via components of the canonical Wnt pathway., [UniProtKB, PubMed]; Characterization of the different oligomeric states of the DAN family antagonists SOSTDC1 and SOST., [RefSeq, PubMed]; While secreted Wise either synergizes or inhibits the Wnt signals depending on the partner ligand, ER-retained Wise consistently blocks the Wnt pathway. ER-retained Wise reduces LRP6 on the cell surface, making cells less susceptible to the Wnt signal., [RefSeq, PubMed]; Wise is able to function cell non-autonomously on neural crest cells and promote trigeminal ganglion formation., [RefSeq, PubMed]; Wise is expressed in regions where other signaling molecules such as Wnt, Bmp, and Shh are known to function in morphogenesis and differentiation., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036122 BMP binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030509 BMP signaling pathway;GO:0030514 negative regulation of BMP signaling pathway;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway;GO:0045596 negative regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q6VYA3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6XXM1-1", "uniprot_id": [ { "id": "CENPA_CHICK", "url": "https://www.uniprot.org/uniprot/Q6XXM1", "type": "external" } ], "mass": 15243.0, "length": 131, "protein_name": "Histone H3-like centromeric protein A", "gene_name": "CENPA", "organism": "Chicken", "refseq_name": "histone H3-like centromeric protein A", "refseq_ac": [ { "id": "NP_001094507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094507", "type": "external" } ], "gene_names_uniprotkb": "CENPA", "gene_names_refseq": "CENP-A; CENPA; ggCENP-A", "protein_names_uniprotkb": "Histone H3-like centromeric protein A; CENP-A; Centromere protein A; GgCENP-A", "protein_names_refseq": "histone H3-like centromeric protein A", "tax_id": 9031, "disease": "", "pathway": " (gga:100113359)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "14563550;15870271;17524417;23277427;28743004;30225548", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992527 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000283.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Analysis of karyology data confirmed that the location of the main CENP-A peaks in chromosomes is the best means of locating the centromeres in 25 galGal5 chromosome models, the majority of which (16) are fully sequenced and assembled. Review article, [RefSeq, PubMed]; CCAN has two distinct roles: recruiting CENP-A to establish the kinetochore and serving as a structural core to directly recruit kinetochore proteins., [RefSeq, PubMed]; CENP-A-depleted cells exhibit a specific defect in maintaining kinetochore localization of the checkpoint protein BubR1 under conditions of checkpoint activation, [RefSeq, PubMed]; Data show that CENP-A induces some positioning of its own and some unwrapping at the entry-exit relative to canonical nucleosomes on both 5 S DNA and the alpha-satellite sequence on which it is normally loaded., [RefSeq, PubMed]; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes (PubMed:14563550). Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:15870271)., [UniProtKB, PubMed, PubMed, UniProtKB]; M18BP1/KNL2 is essential for centromere formation through direct binding to CENP-A nucleosome in non-mammalian vertebrates., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000779 condensed chromosome, centromeric region;GO:0043505 CENP-A containing nucleosome", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0000281 mitotic cytokinesis;GO:0000132 establishment of mitotic spindle orientation;GO:0034080 CENP-A containing chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q6XXM1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q6YI48-1", "uniprot_id": [ { "id": "PTPRU_CHICK", "url": "https://www.uniprot.org/uniprot/Q6YI48", "type": "external" } ], "mass": 161679.0, "length": 1434, "protein_name": "Receptor-type tyrosine-protein phosphatase U", "gene_name": "PTPRU", "organism": "Chicken", "refseq_name": "receptor-type tyrosine-protein phosphatase U precursor", "refseq_ac": [ { "id": "NP_989823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989823", "type": "external" } ], "gene_names_uniprotkb": "PTPRU; RPTPPSI", "gene_names_refseq": "PTPRU", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase U; 3.1.3.48; R-PTP-U; R-PTP-psi; Receptor-type protein-tyrosine phosphatase psi; cRPTPPSI", "protein_names_refseq": "R-PTP-U; R-PTP-psi; cRPTPPSI; phosphoprotein phosphatase; receptor tyrosine phosphatase; receptor-type protein-tyrosine phosphatase psi; receptor-type tyrosine-protein phosphatase U precursor; receptor-type tyrosine-protein phosphatase U", "tax_id": 9031, "disease": "", "pathway": " (gga:395153)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12799079", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY147868.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000339.1., [RefSeq]; Tyrosine-protein phosphatase which dephosphorylates CTNNB1. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q90948", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q6YI48-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q789F3-1", "uniprot_id": [ { "id": "MAF_CHICK", "url": "https://www.uniprot.org/uniprot/Q789F3", "type": "external" } ], "mass": 37708.0, "length": 359, "protein_name": "Transcription factor Maf", "gene_name": "MAF", "organism": "Chicken", "refseq_name": "transcription factor Maf", "refseq_ac": [ { "id": "NP_001038136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038136", "type": "external" } ], "gene_names_uniprotkb": "MAF", "gene_names_refseq": "MAF", "protein_names_uniprotkb": "Transcription factor Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog", "protein_names_refseq": "c-Maf; proto-oncogene c-maf; transcription factor Maf; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:693248)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11036080;12081646;26719333;7935473", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D28598.1, SRR13267655.176341.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from D28598.1., [RefSeq]; Acts as a transcriptional activator or repressor. Positively regulates the expression of alpha A crystallin genes during lens fiber cell differentiation. Binds to Maf recognition elements (MARE)., [UniProtKB, PubMed]; Roles as nuclear effectors of FGF signaling in mouse embryonic lens. Collectively, these studies show that FGF signaling up-regulates expression of alphaA-crystallin both directly and indirectly via up-regulation of c-Maf., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q789F2;Q90786;Q92171", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030219 megakaryocyte differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q789F3-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7T0L4-1", "uniprot_id": [ { "id": "TE2IP_CHICK", "url": "https://www.uniprot.org/uniprot/Q7T0L4", "type": "external" } ], "mass": 36182.0, "length": 329, "protein_name": "Telomeric repeat-binding factor 2-interacting protein 1", "gene_name": "TERF2IP", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TERF2IP; RAP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Telomeric repeat-binding factor 2-interacting protein 1; RAP1 homolog; Repressor/activator protein 1 homolog; TERF2-interacting telomeric protein 1; TRF2-interacting telomeric protein 1; cRAP1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395122); (R-GGA-418124)", "pathway_count": 2, "publication_count": 7, "publication_id_list": "10338214;10571037;14659874;14966288;15383534;16943437;18587156", "class_list": "", "function": "Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8JGU1", "ec_number_list": [], "go_molecular_function": "GO:0042162 telomeric DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0070187 shelterin complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0010833 telomere maintenance via telomere lengthening;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0031848 protection from non-homologous end joining at telomere;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q7T0L4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7T2H2-1", "uniprot_id": [ { "id": "FGRL1_CHICK", "url": "https://www.uniprot.org/uniprot/Q7T2H2", "type": "external" } ], "mass": 54099.0, "length": 487, "protein_name": "Fibroblast growth factor receptor-like 1", "gene_name": "FGFRL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FGFRL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Fibroblast growth factor receptor-like 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395107)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12813049", "class_list": "", "function": "Has a negative effect on cell proliferation., [UniProtKB, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0008201 heparin binding;GO:0017134 fibroblast growth factor binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q7T2H2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7T2Z5-1", "uniprot_id": [ { "id": "UNC5C_CHICK", "url": "https://www.uniprot.org/uniprot/Q7T2Z5", "type": "external" } ], "mass": 102906.0, "length": 931, "protein_name": "Netrin receptor UNC5C", "gene_name": "UNC5C", "organism": "Chicken", "refseq_name": "netrin receptor UNC5C isoform 1 precursor", "refseq_ac": [ { "id": "NP_989782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989782", "type": "external" } ], "gene_names_uniprotkb": "UNC5C", "gene_names_refseq": "UNC5C", "protein_names_uniprotkb": "Netrin receptor UNC5C; Protein unc-5 homolog 3; Protein unc-5 homolog C; cUNC-5H3", "protein_names_refseq": "UNC5-like protein 3; cUNC-5H3; netrin receptor UNC5C isoform 1 precursor; netrin receptor UNC5C; protein unc-5 homolog 3; protein unc-5 homolog C; unc-5 homolog 3", "tax_id": 9031, "disease": "", "pathway": " (gga:395101)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12799087;28483977", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AY187310.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Nov 17, 2021 this sequence version replaced NP_989782.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Receptor for netrin required for axon guidance (By similarity). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). Involved in dorsal root ganglion axon projection towards the spinal cord (PubMed:28483977)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005042 netrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030027 lamellipodium;GO:0030425 dendrite;GO:0030426 growth cone", "go_biological_process": "GO:0007411 axon guidance;GO:1990791 dorsal root ganglion development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7T2Z5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q7T3T4-1", "uniprot_id": [ { "id": "SMS1_CHICK", "url": "https://www.uniprot.org/uniprot/Q7T3T4", "type": "external" } ], "mass": 49014.0, "length": 417, "protein_name": "Phosphatidylcholine:ceramide cholinephosphotransferase 1", "gene_name": "SGMS1", "organism": "Chicken", "refseq_name": "phosphatidylcholine:ceramide cholinephosphotransferase 1", "refseq_ac": [ { "id": "NP_989721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989721", "type": "external" } ], "gene_names_uniprotkb": "SGMS1; MOB; RCJMB04_29o9", "gene_names_refseq": "MOB; SGMS1; TMEM23", "protein_names_uniprotkb": "Phosphatidylcholine:ceramide cholinephosphotransferase 1; 2.7.8.27; Protein Mob; Sphingomyelin synthase 1", "protein_names_refseq": "phosphatidylcholine:ceramide cholinephosphotransferase 1; protein Mob; transmembrane protein 23", "tax_id": 9031, "disease": "", "pathway": " (gga:378907)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15642098;21647613", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720919.1, AY280962.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000227.1. On Oct 10, 2004 this sequence version replaced NP_989721.1., [RefSeq]; Major sphingomyelin synthase at the Golgi apparatus. Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction depends on the levels of CER and DAG in Golgi membranes. Converts the newly synthesized CER, that is transported from the endoplasmic reticulum to the trans-Golgi by the Cer transport protein (CERT), to SM. Can form a heteromeric complex with glucosylceramide synthase (GCS) increasing SMS activity and reducing glucosylceramide synthesis, a critical mechanism that controls the metabolic fate of CER in the Golgi (By similarity). Does not use free phosphorylcholine or CDP-choline as donor. Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to CER to form ceramide phosphoethanolamine (CPE) (By similarity). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting. Plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Molecular cloning, sequence characterization, and tissue expression analysis of chicken sphingomyelin synthase 1 (SMS1).These data serve as a foundation for further insight into the chicken SMS1 gene., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZI65", "ec_number_list": [ { "id": "2.7.8.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.27", "type": "external" }, { "id": "3.1.4.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.62", "type": "external" } ], "go_molecular_function": "GO:0033188 sphingomyelin synthase activity;GO:0047493 ceramide cholinephosphotransferase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006686 sphingomyelin biosynthetic process;GO:0006954 inflammatory response;GO:0043066 negative regulation of apoptotic process;GO:0046513 ceramide biosynthetic process;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q7T3T4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q804X6-1", "uniprot_id": [ { "id": "FA9_CHICK", "url": "https://www.uniprot.org/uniprot/Q804X6", "type": "external" } ], "mass": 51804.0, "length": 471, "protein_name": "Coagulation factor IX", "gene_name": "F9", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "F9", "gene_names_refseq": "", "protein_names_uniprotkb": "Coagulation factor IX; 3.4.21.22; Christmas factor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:374258)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12624623", "class_list": "", "function": "Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0031638 zymogen activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q804X6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q805F9-1", "uniprot_id": [ { "id": "DDB1_CHICK", "url": "https://www.uniprot.org/uniprot/Q805F9", "type": "external" } ], "mass": 126955.0, "length": 1140, "protein_name": "DNA damage-binding protein 1", "gene_name": "DDB1", "organism": "Chicken", "refseq_name": "DNA damage-binding protein 1", "refseq_ac": [ { "id": "NP_989547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989547", "type": "external" } ], "gene_names_uniprotkb": "DDB1; RCJMB04_6h2", "gene_names_refseq": "DDB1", "protein_names_uniprotkb": "DNA damage-binding protein 1; DDB p127 subunit; Damage-specific DNA-binding protein 1; UV-damaged DNA-binding factor", "protein_names_refseq": "DDB p127 subunit; DNA damage-binding protein 1; UV-damaged DNA-binding factor; damage-specific DNA binding protein 1, 127kDa", "tax_id": 9031, "disease": "", "pathway": " (gga:374050); (R-GGA-353303)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "12773817;15572677;15642098;1764072;17976535;25043012", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719779.1, AB074298.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000212.1., [RefSeq]; Protein, which is both involved in DNA repair and protein ubiquitination, as part of the UV-DDB complex and DCX (DDB1-CUL4-X-box) complexes, respectively (By similarity). Core component of the UV-DDB complex (UV-damaged DNA-binding protein complex), a complex that recognizes UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also functions as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (Probable). The functional specificity of the DCX E3 ubiquitin-protein ligase complex is determined by the variable substrate recognition component recruited by DDB1 (By similarity). May play a role in the regulation of the circadian clock (By similarity)., [UniProtKB, PubMed, UniProtKB]; These results demonstrate that the DDB1 gene is indispensable for cell viability in higher vertebrates and this conditional DDB1-knockout clone would be highly useful for the functional analysis of DDB1., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0031464 Cul4A-RING E3 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006281 DNA repair;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0042752 regulation of circadian rhythm;GO:0048511 rhythmic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q805F9-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8AV28-1", "uniprot_id": [ { "id": "PCM1_CHICK", "url": "https://www.uniprot.org/uniprot/Q8AV28", "type": "external" } ], "mass": 212725.0, "length": 1904, "protein_name": "Pericentriolar material 1 protein", "gene_name": "PCM1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PCM1", "gene_names_refseq": "", "protein_names_uniprotkb": "Pericentriolar material 1 protein; PCM-1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395204)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12403812", "class_list": "", "function": "Required for centrosome assembly and function (PubMed:12403812). Essential for the correct localization of several centrosomal proteins including CETN3 and PCNT (By similarity). Required to anchor microtubules to the centrosome (PubMed:12403812). Probably involved in the biogenesis of cilia (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005813 centrosome;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body", "go_biological_process": "GO:0090316 positive regulation of intracellular protein transport;GO:0060271 cilium assembly;GO:0035735 intraciliary transport involved in cilium assembly;GO:1905515 non-motile cilium assembly;GO:0071539 protein localization to centrosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8AV28-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8AXL1-1", "uniprot_id": [ { "id": "SAT1_CHICK", "url": "https://www.uniprot.org/uniprot/Q8AXL1", "type": "external" } ], "mass": 19965.0, "length": 171, "protein_name": "Diamine acetyltransferase 1", "gene_name": "SAT1", "organism": "Chicken", "refseq_name": "diamine acetyltransferase 1", "refseq_ac": [ { "id": "NP_989517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989517", "type": "external" } ], "gene_names_uniprotkb": "SAT1; SAT; SSAT", "gene_names_refseq": "SAT1; SAT", "protein_names_uniprotkb": "Diamine acetyltransferase 1; 2.3.1.57; Polyamine N-acetyltransferase 1; Putrescine acetyltransferase; SSAT-1; SSAT; Spermidine/spermine N(1)-acetyltransferase 1", "protein_names_refseq": "SSAT-1; SSAT; diamine acetyltransferase 1; polyamine N-acetyltransferase 1; putrescine acetyltransferase; spermidine/spermine N(1)-acetyltransferase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:374006); (R-GGA-351200)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12076082", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01110354.1, HAEL01000344.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992437 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000021.1., [RefSeq]; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)-acetylspermine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.57", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004145 diamine N-acetyltransferase activity;GO:0019809 spermidine binding;GO:0008080 N-acetyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0001525 angiogenesis;GO:0006596 polyamine biosynthetic process;GO:0009447 putrescine catabolic process;GO:0032918 spermidine acetylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8AXL1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8AXU9-1", "uniprot_id": [ { "id": "SH3G3_CHICK", "url": "https://www.uniprot.org/uniprot/Q8AXU9", "type": "external" } ], "mass": 40005.0, "length": 353, "protein_name": "Endophilin-A3", "gene_name": "SH3GL3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SH3GL3; SH3P13", "gene_names_refseq": "", "protein_names_uniprotkb": "Endophilin-A3; Endophilin-3; SH3 domain-containing GRB2-like protein 3; SH3p13", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395201)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12606338", "class_list": "", "function": "Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Implicated in endocytosis of yolk proteins during oogenesis., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0016020 membrane;GO:0031901 early endosome membrane;GO:0098793 presynapse", "go_biological_process": "GO:0006897 endocytosis;GO:0061024 membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8AXU9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8AXV0-1", "uniprot_id": [ { "id": "SH3G1_CHICK", "url": "https://www.uniprot.org/uniprot/Q8AXV0", "type": "external" } ], "mass": 41732.0, "length": 367, "protein_name": "Endophilin-A2", "gene_name": "SH3GL1", "organism": "Chicken", "refseq_name": "endophilin-A2", "refseq_ac": [ { "id": "NP_989860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989860", "type": "external" } ], "gene_names_uniprotkb": "SH3GL1; SH3P8", "gene_names_refseq": "SH3GL1; SH3P8", "protein_names_uniprotkb": "Endophilin-A2; Endophilin-2; SH3 domain-containing GRB2-like protein 2; SH3p8", "protein_names_refseq": "SH3 domain-containing GRB2-like protein 2; SH3-domain GRB2-like 1; endophilin II; endophilin-2; endophilin-A2", "tax_id": 9031, "disease": "", "pathway": " (gga:395202)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12606338", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.243914.1, AJ439351.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000375.1., [RefSeq]; Implicated in endocytosis. In a first step mediates neck formation during ultrafast endocytosis and function at a second step to aid in the removal of clathrin coats from the regenerated vesicles (By similarity). May recruit other proteins to membranes with high curvature (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0016020 membrane;GO:0002102 podosome;GO:0031901 early endosome membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0061024 membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8AXV0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8AXV1-1", "uniprot_id": [ { "id": "SH3G2_CHICK", "url": "https://www.uniprot.org/uniprot/Q8AXV1", "type": "external" } ], "mass": 39934.0, "length": 353, "protein_name": "Endophilin-A1", "gene_name": "SH3GL2", "organism": "Chicken", "refseq_name": "endophilin-A1", "refseq_ac": [ { "id": "NP_989861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989861", "type": "external" } ], "gene_names_uniprotkb": "SH3GL2; SH3P4", "gene_names_refseq": "SH3GL2; SH3P4", "protein_names_uniprotkb": "Endophilin-A1; Endophilin-1; SH3 domain-containing GRB2-like protein 1; SH3p4", "protein_names_refseq": "SH3 domain-containing GRB2-like protein 1; SH3-domain GRB2-like 2; endophilin I; endophilin-1; endophilin-A1", "tax_id": 9031, "disease": "", "pathway": " (gga:395203)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12606338", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01016792.1, HAEK01046094.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000092.1., [RefSeq]; Implicated in endocytosis. Involved ultrafast endocytosis, by mediating, in a first step, neck formation and in a second step, aids in the removal of clathrin coats from the regenerated vesicles. May recruit other proteins to membranes with high curvature., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0008289 lipid binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005769 early endosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0098793 presynapse", "go_biological_process": "GO:0097749 membrane tubulation;GO:0048488 synaptic vesicle endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8AXV1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JG54-1", "uniprot_id": [ { "id": "RGMA_CHICK", "url": "https://www.uniprot.org/uniprot/Q8JG54", "type": "external" } ], "mass": 47775.0, "length": 432, "protein_name": "Repulsive guidance molecule A", "gene_name": "RGMA", "organism": "Chicken", "refseq_name": "repulsive guidance molecule A precursor", "refseq_ac": [ { "id": "NP_989868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989868", "type": "external" } ], "gene_names_uniprotkb": "RGMA; RGM", "gene_names_refseq": "RGMA", "protein_names_uniprotkb": "Repulsive guidance molecule A", "protein_names_refseq": "RGM domain family, member A; repulsive guidance molecule A precursor; repulsive guidance molecule A", "tax_id": 9031, "disease": "", "pathway": " (gga:395214)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12353034;15258590;15258591;16738252;18280178;23073896;26292756", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.128529.1, AY128507.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992692 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000245.1. On Jan 1, 2015 this sequence version replaced NP_989868.1., [RefSeq]; Acts as an axon-specific repulsive guidance molecule in the retinotectal system. Repulsive for a subset of axons of the temporal half of the retina. Provides thus positional information for the temporal axons invading the optic tectum in the stratum opticum., [UniProtKB]; C-RGMa activates the Leukemia-associated RhoGEF (LARG)/Rho/Rock pathway to block axonal growth., [RefSeq, PubMed]; RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance molecules in notochord formation, somitogenesis, and myogenesis., [RefSeq, PubMed]; RGMa overexpression promotes neuronal differentiation, whereas RGMa small interference RNA represses it., [RefSeq, PubMed]; Repulsive guidance molecule A expression on retinal axons is a major determinant of topographic targeting in the retino-tectal projection and in the retina., [RefSeq, PubMed]; Repulsive guidance molecule is mediated by the action of neogenin., [RefSeq, PubMed]; Repulsive guidance molecule regulates neuronal survival., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0030509 BMP signaling pathway;GO:0010604 positive regulation of macromolecule metabolic process;GO:0080090 regulation of primary metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q8JG54-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JGM4-1", "uniprot_id": [ { "id": "QSOX1_CHICK", "url": "https://www.uniprot.org/uniprot/Q8JGM4", "type": "external" } ], "mass": 83079.0, "length": 743, "protein_name": "Sulfhydryl oxidase 1", "gene_name": "QSOX1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "QSOX1; QSCN6; QSOX; SOX", "gene_names_refseq": "", "protein_names_uniprotkb": "Sulfhydryl oxidase 1; 1.8.3.2; Quiescin Q6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:373914)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10542195;12176051", "class_list": "", "function": "Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" } ], "go_molecular_function": "GO:0016971 flavin-dependent sulfhydryl oxidase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q8JGM4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8JJC0-1", "uniprot_id": [ { "id": "ZIC1_CHICK", "url": "https://www.uniprot.org/uniprot/Q8JJC0", "type": "external" } ], "mass": 48165.0, "length": 444, "protein_name": "Zinc finger protein ZIC 1", "gene_name": "ZIC1", "organism": "Chicken", "refseq_name": "zinc finger protein ZIC 1", "refseq_ac": [ { "id": "NP_989585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989585", "type": "external" } ], "gene_names_uniprotkb": "ZIC1; ZIC", "gene_names_refseq": "ZIC1", "protein_names_uniprotkb": "Zinc finger protein ZIC 1; Zinc finger protein of the cerebellum 1", "protein_names_refseq": "Zic family member 1 (odd-paired homolog, Drosophila); zinc finger protein ZIC 1; zinc finger protein Zic1; zinc finger protein of the cerebellum 1", "tax_id": 9031, "disease": "", "pathway": " (gga:374103)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "11944941;22639388;24371071", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB078610.1, SRR13267649.295135.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1. On Nov 24, 2021 this sequence version replaced NP_989585.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity)., [UniProtKB, PubMed]; Data have identified a novel chick gene and show it has a role in the correct specification of Zic-1 at the neural plate border., [RefSeq, PubMed]; MYC, TERT, and ZIC1 genes are common targets of viral integration., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0021510 spinal cord development;GO:0030154 cell differentiation;GO:0042472 inner ear morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q8JJC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QFP1-1", "uniprot_id": [ { "id": "NSG1_CHICK", "url": "https://www.uniprot.org/uniprot/Q8QFP1", "type": "external" } ], "mass": 21075.0, "length": 185, "protein_name": "Neuronal vesicle trafficking-associated protein 1", "gene_name": "NSG1", "organism": "Chicken", "refseq_name": "neuronal vesicle trafficking-associated protein 1", "refseq_ac": [ { "id": "NP_989896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989896", "type": "external" } ], "gene_names_uniprotkb": "NSG1", "gene_names_refseq": "NSG1", "protein_names_uniprotkb": "Neuronal vesicle trafficking-associated protein 1; Neuron-specific protein family member 1; Protein LZ1", "protein_names_refseq": "LZ1; Protein LZ1; neuron specific gene family member 1; neuron-specific protein family member 1; neuronal vesicle trafficking-associated protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:395251)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "21404368", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF498103.1, HAEL01011319.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000074.1., [RefSeq]; Expression of NSG1 in two apparently unrelated cell types such as neurons and germ cells suggests NSG1 roles in neurons and germ-cells chemotaxis and endocytotic machinery., [RefSeq, PubMed]; Plays a role in the recycling mechanism in neurons of multiple receptors and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032051 clathrin light chain binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0099627 neurotransmitter receptor cycle;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0006915 apoptotic process;GO:0042982 amyloid precursor protein metabolic process;GO:0016197 endosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8QFP1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QG60-1", "uniprot_id": [ { "id": "CRY2_CHICK", "url": "https://www.uniprot.org/uniprot/Q8QG60", "type": "external" } ], "mass": 66097.0, "length": 582, "protein_name": "Cryptochrome-2", "gene_name": "CRY2", "organism": "Chicken", "refseq_name": "cryptochrome-2", "refseq_ac": [ { "id": "NP_989575", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989575", "type": "external" } ], "gene_names_uniprotkb": "CRY2", "gene_names_refseq": "CRY2; gCry2", "protein_names_uniprotkb": "Cryptochrome-2", "protein_names_refseq": "cryptochrome 2 (photolyase-like); cryptochrome circadian clock 2; cryptochrome-2", "tax_id": 9031, "disease": "", "pathway": " (gga:374092)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11684328;11904144;15459395;19456395", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.195175.1, AY034433.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000214.1. This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. [provided by RefSeq, Feb 2014]., [RefSeq]; Data characterize a non-opsin photoreception mechanism in the chick iris and suggest a conserved photoreceptive role for cryptochromes in vertebrates, [RefSeq, PubMed]; Light-sensitive clock components in the pinealocytes may be involved in the repression of Cry2 transcription at night, which may contribute to resetting the phase of the clock within 24 h, [RefSeq, PubMed]; Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, BMAL1, BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and BMAL1 or BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-BMAL1|BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2, RORA/B/G, which form a second feedback loop and which activate and repress BMAL1 transcription, respectively. CRY1 and CRY2 have redundant functions but also differential and selective contributions at least in defining the pace of the SCN circadian clock and its circadian transcriptional outputs. Less potent transcriptional repressor in cerebellum and liver than CRY1, though less effective in lengthening the period of the SCN oscillator. Seems to play a critical role in tuning SCN circadian period by opposing the action of CRY1. With CRY1, dispensable for circadian rhythm generation but necessary for the development of intercellular networks for rhythm synchrony (By similarity). Represses CLOCK-BMAL1-mediated transcriptional activation (PubMed:11684328)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q8QG52;Q8QGQ5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0071949 FAD binding;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097381 photoreceptor disc membrane;GO:0042622 photoreceptor outer segment membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0007623 circadian rhythm;GO:0042752 regulation of circadian rhythm;GO:0032922 circadian regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8QG60-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QGH3-1", "uniprot_id": [ { "id": "CAD20_CHICK", "url": "https://www.uniprot.org/uniprot/Q8QGH3", "type": "external" } ], "mass": 89157.0, "length": 798, "protein_name": "Cadherin-20", "gene_name": "CDH20", "organism": "Chicken", "refseq_name": "cadherin-20 precursor", "refseq_ac": [ { "id": "NP_989465", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989465", "type": "external" } ], "gene_names_uniprotkb": "CDH20", "gene_names_refseq": "CDH20", "protein_names_uniprotkb": "Cadherin-20; F-cadherin; MN-cadherin", "protein_names_refseq": "MN-cadherin; cadherin-20 precursor; cadherin-20", "tax_id": 9031, "disease": "", "pathway": " (gga:373927)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12007407;15992777;16564015;19218874", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF459439.1, AF465257.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000040.1., [RefSeq]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB, PubMed, PubMed, PubMed]; Findings show that cadherin-20 expression in motor neurons is regulated by Sonic hedgehog in a time-dependent manner, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q7ZYV7;Q804X8", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q8QGH3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q8QGP3-1", "uniprot_id": [ { "id": "CBPZ_CHICK", "url": "https://www.uniprot.org/uniprot/Q8QGP3", "type": "external" } ], "mass": 73919.0, "length": 647, "protein_name": "Carboxypeptidase Z", "gene_name": "CPZ", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CPZ", "gene_names_refseq": "", "protein_names_uniprotkb": "Carboxypeptidase Z; 3.4.17.-; CPZ; cCPZ", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "12944424", "class_list": "", "function": "Cleaves substrates with C-terminal arginine residues. Modulates the Wnt signaling pathway, probably by cleaving some undefined protein. Regulates the development of skeletal elements during development, probably by activating WNT4., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016485 protein processing;GO:0006518 peptide metabolic process;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q8QGP3-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90592-1", "uniprot_id": [ { "id": "GTR2_CHICK", "url": "https://www.uniprot.org/uniprot/Q90592", "type": "external" } ], "mass": 57699.0, "length": 533, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 2", "gene_name": "SLC2A2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC2A2; GLUT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 2; GLUT-2; Glucose transporter type 2, liver", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396272); (R-GGA-352832)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "8161202;8589457", "class_list": "", "function": "Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells. Also able to mediate the transport of dehydroascorbate and urate., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity;GO:0005354 galactose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0015755 fructose transmembrane transport;GO:0015757 galactose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90592-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90600-1", "uniprot_id": [ { "id": "RB_CHICK", "url": "https://www.uniprot.org/uniprot/Q90600", "type": "external" } ], "mass": 104436.0, "length": 921, "protein_name": "Retinoblastoma-associated protein", "gene_name": "RB1", "organism": "Chicken", "refseq_name": "retinoblastoma-associated protein", "refseq_ac": [ { "id": "NP_989750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989750", "type": "external" } ], "gene_names_uniprotkb": "RB1", "gene_names_refseq": "RB1", "protein_names_uniprotkb": "Retinoblastoma-associated protein; Rb; p104; pRb", "protein_names_refseq": "p104; pRb; rb; retinoblastoma 1 (including osteosarcoma); retinoblastoma-associated protein", "tax_id": 9031, "disease": "", "pathway": " (gga:386582)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10400747;21906182;23155027;25100553;30784300;31398034;8180136;8193168", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267661.18291.1, SRR13267649.33835.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000027.1. On Sep 23, 2021 this sequence version replaced NP_989750.1. Sequence Note: This sequence has been modified as follows: removed 77 bp suspected to be vector contamination from the 3' end., [RefSeq]; Experiments showed an essential role of pRb in S-phase entry of the supporting cells in the damaged neonatal chicken utricle and have shown that the proliferation of these cells requires the phosphorylation of pRb Erratum:[Neuroreport. 2024 Nov 6;35(16):1061-1062. doi: 10.1097/WNR.0000000000002102. PMID: 39324944], [RefSeq, PubMed]; Gene expression analysis showed that gRB1 knockdown promoted markers indicating proliferation of Ki-67 (MKi67) expression at 96 h (P < 0.05), and overexpression of gRB1 reduced MKi67 expression at 72 h (P < 0.05)., [RefSeq, PubMed]; SNP g.32828A>G of RB1 is an obesity-associated variant that directly affects binding with NF-KB and SOX2, leading to changes in RB1 expression which in turn may influence chicken abdominal fat deposition., [RefSeq, PubMed]; The RB1 gene was a major gene for body weight and bone traits, [RefSeq, PubMed]; The cell cycle-related gene RB1 showed higher expression in the cultured chicken embryonic fibroblast cells than that of cultured chicken primordial germ cells., [RefSeq, PubMed]; Tumor suppressor that is a key regulator of the G1/S transition of the cell cycle. The hypophosphorylated form binds transcription regulators of the E2F family, preventing transcription of E2F-responsive genes. Both physically blocks E2Fs transactivating domain and recruits chromatin-modifying enzymes that actively repress transcription. Cyclin and CDK-dependent phosphorylation of RB1 induces its dissociation from E2Fs, thereby activating transcription of E2F responsive genes and triggering entry into S phase. RB1 also promotes the G0-G1 transition upon phosphorylation and activation by CDK3/cyclin-C., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q788Q6;Q90599;Q91016", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0035189 Rb-E2F complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0031175 neuron projection development;GO:0030308 negative regulation of cell growth", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q90600-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90631-1", "uniprot_id": [ { "id": "KTN1_CHICK", "url": "https://www.uniprot.org/uniprot/Q90631", "type": "external" } ], "mass": 155976.0, "length": 1364, "protein_name": "Kinectin", "gene_name": "KTN1", "organism": "Chicken", "refseq_name": "kinectin", "refseq_ac": [ { "id": "NP_990707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990707", "type": "external" } ], "gene_names_uniprotkb": "KTN1", "gene_names_refseq": "KTN1", "protein_names_uniprotkb": "Kinectin", "protein_names_refseq": "kinectin 1 (kinesin receptor); kinectin", "tax_id": 9031, "disease": "", "pathway": " (gga:396335)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7787244;9822636", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U15617.1, SRR13267649.232155.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000215.1. On Sep 23, 2021 this sequence version replaced NP_990707.1., [RefSeq]; Receptor for kinesin thus involved in kinesin-driven vesicle motility., [UniProtKB]", "predicted_glycosites": 10, "predicted_n_glycosites": 10, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019894 kinesin binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0015031 protein transport;GO:0007018 microtubule-based movement", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90631-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90647-1", "uniprot_id": [ { "id": "VATA_CHICK", "url": "https://www.uniprot.org/uniprot/Q90647", "type": "external" } ], "mass": 68476.0, "length": 617, "protein_name": "V-type proton ATPase catalytic subunit A", "gene_name": "ATP6V1A", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ATP6V1A", "gene_names_refseq": "", "protein_names_uniprotkb": "V-type proton ATPase catalytic subunit A; 7.1.2.2; V-ATPase 69 kDa subunit; V-ATPase subunit A; Vacuolar proton pump subunit alpha", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395821)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7597085", "class_list": "", "function": "Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in neurite development and synaptic connectivity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90646", "ec_number_list": [ { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0046034 ATP metabolic process;GO:0036295 cellular response to increased oxygen levels;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90647-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90660-1", "uniprot_id": [ { "id": "BIR_CHICK", "url": "https://www.uniprot.org/uniprot/Q90660", "type": "external" } ], "mass": 69010.0, "length": 611, "protein_name": "Inhibitor of apoptosis protein", "gene_name": "ITA", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ITA; IAP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Inhibitor of apoptosis protein; IAP; Inhibitor of T-cell apoptosis protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:374012)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8945639;9372964", "class_list": "", "function": "Apoptotic suppressor., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O57319", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:0031398 positive regulation of protein ubiquitination;GO:0060546 negative regulation of necroptotic process;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90660-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90663-1", "uniprot_id": [ { "id": "SEM3D_CHICK", "url": "https://www.uniprot.org/uniprot/Q90663", "type": "external" } ], "mass": 87300.0, "length": 761, "protein_name": "Semaphorin-3D", "gene_name": "SEMA3D", "organism": "Chicken", "refseq_name": "semaphorin-3D precursor", "refseq_ac": [ { "id": "NP_990704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990704", "type": "external" } ], "gene_names_uniprotkb": "SEMA3D; COLL2", "gene_names_refseq": "COLL2; SEMA3D; collapsin; semaphorin-3D", "protein_names_uniprotkb": "Semaphorin-3D; COLL-2; Collapsin-2", "protein_names_refseq": "COLL-2; collapsin-2; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; semaphorin-3D precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:396332)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "16261621;16804892;7605628", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267652.10221.1, SRR13267656.21890.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000011.1. On Sep 20, 2021 this sequence version replaced NP_990704.1., [RefSeq]; Expressed in the tips of the embryonic ventricular trabeculae., [RefSeq, PubMed]; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin., [UniProtKB]; Sema3D expression is limited to neural crest cells migrating out of the midbrain/hindbrain regions, while Sema7A expression is widespread in both cranial and trunk neural crest cells, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0050919 negative chemotaxis;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q90663-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90690-1", "uniprot_id": [ { "id": "HAND2_CHICK", "url": "https://www.uniprot.org/uniprot/Q90690", "type": "external" } ], "mass": 24407.0, "length": 216, "protein_name": "Heart- and neural crest derivatives-expressed protein 2", "gene_name": "HAND2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HAND2; DHAND", "gene_names_refseq": "", "protein_names_uniprotkb": "Heart- and neural crest derivatives-expressed protein 2; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10769237;8533092", "class_list": "", "function": "Essential for cardiac morphogenesis. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). Plays an important role in limb development, particularly in the establishment of anterior-posterior polarization of the limb bud., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0009949 polarity specification of anterior/posterior axis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0060174 limb bud formation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90690-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90693-1", "uniprot_id": [ { "id": "PTC1_CHICK", "url": "https://www.uniprot.org/uniprot/Q90693", "type": "external" } ], "mass": 160578.0, "length": 1442, "protein_name": "Protein patched homolog 1", "gene_name": "PTCH1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTCH1; PTCH; PTC", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein patched homolog 1; PTC1; PTC", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "8620849;8906794", "class_list": "", "function": "Negative regulator of the smoothened signaling pathway, which acts as a receptor for hedgehog (SHH, IHH and DHH) morphogens (PubMed:8906794). In absence of hedgehog, acts as an inhibitor of smoothened protein (SMO) by preventing SMO access to cholesterol: mechanistically, acts as a cholesterol transporter, which depeletes cholesterol from the outer leaflet of plasma membrane, thereby preventing cholesterol-binding to the extracellular CRD region of SMO (By similarity). Hedgehog-binding inhibits PTCH1 cholesterol transporter activity, promoting SMO activation by cholesterol and transduction of the smoothened signaling pathway (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097108 hedgehog family protein binding;GO:0008158 hedgehog receptor activity;GO:0005119 smoothened binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007224 smoothened signaling pathway;GO:0045879 negative regulation of smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90693-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90705-1", "uniprot_id": [ { "id": "EF2_CHICK", "url": "https://www.uniprot.org/uniprot/Q90705", "type": "external" } ], "mass": 95378.0, "length": 858, "protein_name": "Elongation factor 2", "gene_name": "EEF2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EEF2", "gene_names_refseq": "", "protein_names_uniprotkb": "Elongation factor 2; 3.6.5.-; EF-2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396325)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1708237", "class_list": "", "function": "Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90705-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90734-1", "uniprot_id": [ { "id": "ACTN4_CHICK", "url": "https://www.uniprot.org/uniprot/Q90734", "type": "external" } ], "mass": 104207.0, "length": 904, "protein_name": "Alpha-actinin-4", "gene_name": "ACTN4", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ACTN4", "gene_names_refseq": "", "protein_names_uniprotkb": "Alpha-actinin-4; Non-muscle alpha-actinin 4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396024)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1334489;8055908", "class_list": "", "function": "F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. Involved in tight junction assembly in epithelial cells. May also function as a transcriptional coactivator, stimulating transcription mediated by nuclear hormone receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030036 actin cytoskeleton organization;GO:0048384 retinoic acid receptor signaling pathway;GO:0035357 peroxisome proliferator activated receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90734-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90751-1", "uniprot_id": [ { "id": "BMP2_CHICK", "url": "https://www.uniprot.org/uniprot/Q90751", "type": "external" } ], "mass": 40347.0, "length": 353, "protein_name": "Bone morphogenetic protein 2", "gene_name": "BMP2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "BMP2; BMP-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Bone morphogenetic protein 2; BMP-2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "8119128;9927590", "class_list": "", "function": "Negatively regulates the structure and function of the limb apical ectodermal ridge., [UniProtKB, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0003007 heart morphogenesis;GO:0030509 BMP signaling pathway;GO:0001649 osteoblast differentiation;GO:0010718 positive regulation of epithelial to mesenchymal transition;GO:0060317 cardiac epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90751-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90762-1", "uniprot_id": [ { "id": "CADH6_CHICK", "url": "https://www.uniprot.org/uniprot/Q90762", "type": "external" } ], "mass": 88660.0, "length": 790, "protein_name": "Cadherin-6", "gene_name": "CDH6", "organism": "Chicken", "refseq_name": "cadherin-6 isoform a precursor", "refseq_ac": [ { "id": "NP_001001758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001758", "type": "external" } ], "gene_names_uniprotkb": "CDH6", "gene_names_refseq": "CDH6; c-cad6B; cadherin-6B; cadherin-6", "protein_names_uniprotkb": "Cadherin-6; Cadherin-6B; c-cad6B", "protein_names_refseq": "cadherin 6, type 2, K-cadherin (fetal kidney); cadherin 6B; cadherin-6 isoform a precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:414842); (R-GGA-418990)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "15312902;17344227;18322922;24196837;25747715;25795298;27856599;7540531", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D42149.1, SRR13267654.269216.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000040.1. On Aug 30, 2004 this sequence version replaced XP_418998.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; A dual mechanism for Cad6B proteolysis involving two ADAMs, along with gamma-secretase, during cranial neural crest cell epithelial-to-mesenchymal transitions., [RefSeq, PubMed]; Cad6B C-terminal fragments possesses a novel pro-epithelial-to-mesenchymal transition (EMT) role by up-regulating EMT effector genes in vivo., [RefSeq, PubMed]; Cad6B is removed from premigratory neural crest cells through cell surface internalization events that include clathrin-mediated endocytosis and macropinocytosis., [RefSeq, PubMed]; Cadherin-6B was expressed in many song nuclei of the juvenile and adult brain., [RefSeq, PubMed]; Cadherin6B is a direct target of Snail2 repression in vivo and in the context of the EMT that characterizes neural crest development., [RefSeq, PubMed]; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types., [UniProtKB]; Expression of cadherin 6B at the synaptic level on the somata and the proximal neurites of identified neuron populations has been traced selectively in the developing chicken visual system., [RefSeq, PubMed]; Knockdown or loss of function of Cadherin-6B suppressed the generation of Islet-1-expressing cells in the dorsal neural tube, but not the Lim-1/2 positive dorsal cell population., [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005912 adherens junction;GO:0016342 catenin complex", "go_biological_process": "GO:0016477 cell migration;GO:0000902 cell morphogenesis;GO:0007043 cell-cell junction assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0034332 adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q90762-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90773-1", "uniprot_id": [ { "id": "CEPU1_CHICK", "url": "https://www.uniprot.org/uniprot/Q90773", "type": "external" } ], "mass": 38736.0, "length": 353, "protein_name": "Protein CEPU-1", "gene_name": "", "organism": "Chicken", "refseq_name": "protein CEPU-1 precursor", "refseq_ac": [ { "id": "NP_990042", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990042", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "CEPU-SE; CEPU; HNT; NTM", "protein_names_uniprotkb": "Protein CEPU-1", "protein_names_refseq": "IgLON family protein; neural secreted glycoprotein; protein CEPU-1 precursor; protein CEPU-1", "tax_id": 9031, "disease": "", "pathway": " (gga:395450)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10330412;8774445", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.213100.1, Z72497.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000341.1. On Sep 23, 2021 this sequence version replaced NP_990042.1., [RefSeq]; CEPU-1 is a novel neural IgSF cell recognition that is strongly expressed by developing Purkinje cells and, at lower levels, in other regions of the CNS. CEPU-1 is a GPI-anchored glycoprotein expressed in the soma, axons and dendrites., [RefSeq, PubMed]; It may be a cellular address molecule specific to Purkinje cells. It may represent a receptor or a subunit of a receptor complex., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0005886 plasma membrane;GO:0098839 postsynaptic density membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0051963 regulation of synapse assembly;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90773-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90805-1", "uniprot_id": [ { "id": "CNG1_CHICK", "url": "https://www.uniprot.org/uniprot/Q90805", "type": "external" } ], "mass": 85032.0, "length": 735, "protein_name": "Cyclic nucleotide-gated channel cone photoreceptor subunit alpha", "gene_name": "", "organism": "Chicken", "refseq_name": "cyclic nucleotide-gated channel cone photoreceptor subunit alpha isoform 1", "refseq_ac": [ { "id": "NP_990552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990552", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "CNGA3", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel cone photoreceptor subunit alpha; CNG channel 1; CNG-1; CNG1", "protein_names_refseq": "CNG channel 1; CNG-1; CNG1; alpha subunit of cone photoreceptor CNG-channel; cyclic nucleotide-gated channel cone photoreceptor subunit alpha isoform 1; cyclic nucleotide-gated channel cone photoreceptor subunit alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:396144)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7684234", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X89598.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA103992290, SAMEA3109051 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000025.1. On Oct 28, 2021 this sequence version replaced NP_990552.1., [RefSeq]; Visual signal transduction is mediated by a G protein-coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0030552 cAMP binding;GO:0030553 cGMP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0017071 intracellular cyclic nucleotide activated cation channel complex", "go_biological_process": "GO:0007601 visual perception;GO:0060041 retina development in camera-type eye;GO:0098655 monoatomic cation transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90805-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90812-1", "uniprot_id": [ { "id": "CRHR1_CHICK", "url": "https://www.uniprot.org/uniprot/Q90812", "type": "external" } ], "mass": 48600.0, "length": 420, "protein_name": "Corticotropin-releasing hormone receptor 1", "gene_name": "CRHR1", "organism": "Chicken", "refseq_name": "corticotropin-releasing factor receptor 1 precursor", "refseq_ac": [ { "id": "NP_989652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989652", "type": "external" } ], "gene_names_uniprotkb": "CRHR1", "gene_names_refseq": "CRHR1", "protein_names_uniprotkb": "Corticotropin-releasing hormone receptor 1; CRF-R-1; CRF-R1; CRFR-1; CRH-R-1; CRH-R1; Corticotropin-releasing factor receptor 1", "protein_names_refseq": "CRF-R-1; CRF-R1; CRFR-1; CRH-R-1; CRH-R1; corticotropin-releasing factor receptor 1 precursor; corticotropin-releasing factor receptor 1", "tax_id": 9031, "disease": "", "pathway": " (gga:374218)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12782401;8536612", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267654.4079.1, SRR13267649.123411.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000363.1. On Nov 4, 2021 this sequence version replaced NP_989652.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; CRHR1 expression is virtually confined to corticotropes, suggesting that CRH-induced adrenocorticotropin release is the result of a direct stimulation of corticotropes, whereas CRH-stimulated TSH release is not directly mediated by the known chicken CRHR1, [RefSeq, PubMed]; G protein-coupled receptor for CRH and UCN stress hormones, which plays a central role in whole body adaptation to stress (PubMed:8536612). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and downstream effectors, such as adenylate cyclase (By similarity). CRHR1 is mainly coupled to G(s) G protein (GNAS), mediating activation of adenylate cyclase activity and production of cAMP (By similarity). In some conditions, can also couple to G(q) G protein (GNAQ) and mediate production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers (By similarity). CRHR1-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity;GO:0015056 corticotrophin-releasing factor receptor activity;GO:0051424 corticotropin-releasing hormone binding;GO:0043404 corticotropin-releasing hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0051458 corticotropin secretion;GO:2000852 regulation of corticosterone secretion;GO:0071376 cellular response to corticotropin-releasing hormone stimulus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90812-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90826-1", "uniprot_id": [ { "id": "CCL4_CHICK", "url": "https://www.uniprot.org/uniprot/Q90826", "type": "external" } ], "mass": 9969.0, "length": 90, "protein_name": "C-C motif chemokine 4 homolog", "gene_name": "CCL4", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CCL4; SCYA4", "gene_names_refseq": "", "protein_names_uniprotkb": "C-C motif chemokine 4 homolog; MIP-1-beta; Macrophage inflammatory protein 1-beta homolog; Small-inducible cytokine A4 homolog", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395551); (R-GGA-380108); (R-GGA-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "10582310;7642115", "class_list": "", "function": "Monokine with inflammatory and chemokinetic properties., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4KS31;Q910C9", "ec_number_list": [], "go_molecular_function": "GO:0008009 chemokine activity;GO:0048020 CCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0030335 positive regulation of cell migration;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0070098 chemokine-mediated signaling pathway;GO:0048245 eosinophil chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90826-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90828-1", "uniprot_id": [ { "id": "DC1L1_CHICK", "url": "https://www.uniprot.org/uniprot/Q90828", "type": "external" } ], "mass": 55893.0, "length": 515, "protein_name": "Cytoplasmic dynein 1 light intermediate chain 1", "gene_name": "DYNC1LI1", "organism": "Chicken", "refseq_name": "cytoplasmic dynein 1 light intermediate chain 1", "refseq_ac": [ { "id": "NP_001161209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161209", "type": "external" } ], "gene_names_uniprotkb": "DYNC1LI1; DNCLI1", "gene_names_refseq": "DLCA; DNCLI1; DYNC1LI1; LIC5759", "protein_names_uniprotkb": "Cytoplasmic dynein 1 light intermediate chain 1; DLC-A; Dynein light chain A; Dynein light intermediate chain 1, cytosolic; LIC57/59", "protein_names_refseq": "DLC-A; LIC57/59; cytoplasmic dynein 1 light intermediate chain 1; dyenin light chain A; dynein light chain A; dynein light intermediate chain 1, cytosolic; dynein, cytoplasmic, light intermediate polypeptide 1", "tax_id": 9031, "disease": "", "pathway": " (gga:420668)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "24951117;7949421", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01017270.1, HAEK01007276.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000037.1. On Nov 18, 2009 this sequence version replaced XP_418767.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (By similarity). May regulate the movement of peripheral sorting endosomes along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (By similarity)., [UniProtKB, UniProtKB]; Dynein generates forces that push the cytoskeletal meshwork forward en masse during axonal elongation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0045504 dynein heavy chain binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005874 microtubule;GO:0030666 endocytic vesicle membrane;GO:0055038 recycling endosome membrane;GO:0000776 kinetochore", "go_biological_process": "GO:0060627 regulation of vesicle-mediated transport;GO:0007018 microtubule-based movement;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90828-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90850-1", "uniprot_id": [ { "id": "HIC1_CHICK", "url": "https://www.uniprot.org/uniprot/Q90850", "type": "external" } ], "mass": 73759.0, "length": 676, "protein_name": "Hypermethylated in cancer 1 protein", "gene_name": "HIC1", "organism": "Chicken", "refseq_name": "hypermethylated in cancer 1 protein isoform 1", "refseq_ac": [ { "id": "NP_990567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990567", "type": "external" } ], "gene_names_uniprotkb": "HIC1", "gene_names_refseq": "HIC1", "protein_names_uniprotkb": "Hypermethylated in cancer 1 protein; GammaFBP; Hic-1", "protein_names_refseq": "gammaFBP-A; hic-1; hypermethylated in cancer 1 protein isoform 1; hypermethylated in cancer 1 protein", "tax_id": 9031, "disease": "", "pathway": " (gga:396164); (R-GGA-3232118)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8088434", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X79051.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992432, SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000323.1., [RefSeq]; Binds specifically to the gamma F-1-binding motif of the gamma F-crystallin promoter. May have a regulatory role in sclerotome specification and/or differentiation. Isoform 2 functions as a transcriptional repressor in lens cells., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q90851;Q90852", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:0030178 negative regulation of Wnt signaling pathway;GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90850-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90867-1", "uniprot_id": [ { "id": "HNF1A_CHICK", "url": "https://www.uniprot.org/uniprot/Q90867", "type": "external" } ], "mass": 69189.0, "length": 634, "protein_name": "Hepatocyte nuclear factor 1-alpha", "gene_name": "HNF1A", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HNF1A; TCF1", "gene_names_refseq": "", "protein_names_uniprotkb": "Hepatocyte nuclear factor 1-alpha; HNF-1-alpha; HNF-1A; TCF-1; Transcription factor 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "7687846;8105803", "class_list": "", "function": "Transcriptional activator that regulates the tissue specific expression of multiple genes, especially in pancreatic islet cells and in liver. May participate in the control of the hormone-dependent expression of the lysozyme gene in the oviduct and liver. In liver it could repress the gene while in oviduct it may act as an activator., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042593 glucose homeostasis;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90867-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90873-1", "uniprot_id": [ { "id": "IFNB_CHICK", "url": "https://www.uniprot.org/uniprot/Q90873", "type": "external" } ], "mass": 23686.0, "length": 203, "protein_name": "Interferon type B", "gene_name": "IFNB", "organism": "Chicken", "refseq_name": "interferon type B precursor", "refseq_ac": [ { "id": "NP_001020007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020007", "type": "external" } ], "gene_names_uniprotkb": "IFNB; IFN2", "gene_names_refseq": "IFN-beta; IFN2; IFNB; IFNW1; IFN_B", "protein_names_uniprotkb": "Interferon type B; IFN-beta", "protein_names_refseq": "interferon type B precursor; interferon type B; interferon, beta 1, fibroblast; interferon-beta", "tax_id": 9031, "disease": "", "pathway": " (gga:554219); (R-GGA-909733); (R-GGA-912694)", "pathway_count": 3, "publication_count": 6, "publication_id_list": "17870162;24934575;25200153;25918711;33609615;8631799", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: AY974089.1, GU119897.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: upstream AUG and CDS extension is not conserved ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000086.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; DEAD/DEAH-box helicase 5 is hijacked by an avian oncogenic herpesvirus to inhibit interferon beta production and promote viral replication., [RefSeq, PubMed]; Data indicate that the expression levels of chick fibroblast DF-1 interferon beta (IFN-beta) and myxovirus resistance-1 (Mx1) mRNA were down-regulated by over-expression of duck albumin (ALB) gene., [RefSeq, PubMed]; Has antiviral activities., [UniProtKB]; Overexpression of TLR3 enhanced the activity of the IFN-beta promoter and the transcription factor NF-kappa B, thereby decreasing viral protein synthesis., [RefSeq, PubMed]; Study observed an upregulation in the expression of both TLR3 and IFNbeta during H5N1 infection in chickens; findings show that poly(I:C)-stimulated IFNbeta expression involves TLR3 signalling, [RefSeq, PubMed]; These results indicate that duRIG-I CARD domain plays an important role in the induction of IFN-b and provide a basis for further studying the function of RIG-I in avian innate immunity, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q4Z8K4", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0034141 positive regulation of toll-like receptor 3 signaling pathway;GO:0002312 B cell activation involved in immune response;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q90873-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90923-1", "uniprot_id": [ { "id": "NET3_CHICK", "url": "https://www.uniprot.org/uniprot/Q90923", "type": "external" } ], "mass": 65107.0, "length": 581, "protein_name": "Netrin-3", "gene_name": "NTN3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NTN3; NTN2", "gene_names_refseq": "", "protein_names_uniprotkb": "Netrin-3; Netrin-2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396387)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8062384", "class_list": "", "function": "Netrins control guidance of CNS commissural axons and peripheral motor axons., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005604 basement membrane", "go_biological_process": "GO:0016358 dendrite development;GO:0006355 regulation of DNA-templated transcription;GO:0009887 animal organ morphogenesis;GO:0007520 myoblast fusion;GO:0009888 tissue development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90923-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90932-1", "uniprot_id": [ { "id": "NFIX_CHICK", "url": "https://www.uniprot.org/uniprot/Q90932", "type": "external" } ], "mass": 46903.0, "length": 431, "protein_name": "Nuclear factor 1 X-type", "gene_name": "NFIX", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NFIX; NFI-X", "gene_names_refseq": "", "protein_names_uniprotkb": "Nuclear factor 1 X-type; CCAAT-box-binding transcription factor; CTF; NF-I/X; NF1-X; NFI-X; Nuclear factor 1/X; Nuclear factor I/X; TGGCA-binding protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396207)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1754401", "class_list": "", "function": "Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006260 DNA replication;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90932-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90944-1", "uniprot_id": [ { "id": "EPYC_CHICK", "url": "https://www.uniprot.org/uniprot/Q90944", "type": "external" } ], "mass": 35857.0, "length": 316, "protein_name": "Epiphycan", "gene_name": "EPYC", "organism": "Chicken", "refseq_name": "epiphycan precursor", "refseq_ac": [ { "id": "NP_001004382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004382", "type": "external" } ], "gene_names_uniprotkb": "EPYC; DSPG3; PGLB", "gene_names_refseq": "DSPG3; EPYC; PGLB", "protein_names_uniprotkb": "Epiphycan; Dermatan sulfate proteoglycan 3; PG-Lb; Proteoglycan-Lb; Small chondroitin/dermatan sulfate proteoglycan", "protein_names_refseq": "PG-Lb; dermatan sulfate proteoglycan 3; epiphycan precursor; proteoglycan core protein; proteoglycan-Lb; small chondroitin/dermatan sulfate proteoglycan", "tax_id": 9031, "disease": "", "pathway": " (gga:417890)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "15224401;1730648", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: D10485.1, SRR13267657.17292.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05341171 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. On Sep 17, 2004 this sequence version replaced XP_416134.1., [RefSeq]; May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization., [UniProtKB]; Weak aggrecan immunoreactivity was limited to the cells arranged into lamellar and interlamellar cell layers. Aggrecan content was very low in all stages examined., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0060348 bone development;GO:0061975 articular cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90944-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90952-1", "uniprot_id": [ { "id": "PON2_CHICK", "url": "https://www.uniprot.org/uniprot/Q90952", "type": "external" } ], "mass": 39409.0, "length": 354, "protein_name": "Serum paraoxonase/arylesterase 2", "gene_name": "PON2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PON2", "gene_names_refseq": "", "protein_names_uniprotkb": "Serum paraoxonase/arylesterase 2; 3.1.1.2; 3.1.8.1; A-esterase 2; Aromatic esterase 2; PON 2; Serum aryldialkylphosphatase 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8661009", "class_list": "", "function": "The absence of paraoxonase activity in turkey and chicken blood and in turkey liver indicates that PON2, if expressed, does not hydrolyze paraoxon., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.2", "type": "external" }, { "id": "3.1.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.8.1", "type": "external" } ], "go_molecular_function": "GO:0004063 aryldialkylphosphatase activity;GO:0046872 metal ion binding;GO:0004064 arylesterase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane", "go_biological_process": "GO:0009636 response to toxic substance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q90952-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90988-1", "uniprot_id": [ { "id": "SMC2_CHICK", "url": "https://www.uniprot.org/uniprot/Q90988", "type": "external" } ], "mass": 134941.0, "length": 1189, "protein_name": "Structural maintenance of chromosomes protein 2", "gene_name": "SMC2", "organism": "Chicken", "refseq_name": "structural maintenance of chromosomes protein 2", "refseq_ac": [ { "id": "NP_990561", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990561", "type": "external" } ], "gene_names_uniprotkb": "SMC2; SCII; SMC2L1", "gene_names_refseq": "SCII; SMC-2; SMC2L1; SMC2", "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 2; Chromosome scaffold protein ScII; SMC protein 2; SMC-2", "protein_names_refseq": "SMC protein 2; SMC2 structural maintenance of chromosomes 2-like 1; chromosome scaffold protein ScII; structural maintenance of chromosomes protein 2", "tax_id": 9031, "disease": "", "pathway": " (gga:396156)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "18480406;7929577", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X80792.1, SRR13267661.3876.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000095.1. On Sep 23, 2021 this sequence version replaced NP_990561.1., [RefSeq]; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases., [UniProtKB]; Topological integrity of the SMC2-SMC4 heterodimer is not necessary for the stability of the condensin complex in vitro or for its stable association with mitotic chromosomes, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0031981 nuclear lumen;GO:0005737 cytoplasm;GO:0000793 condensed chromosome;GO:0000785 chromatin;GO:0000796 condensin complex", "go_biological_process": "GO:0051301 cell division;GO:0007076 mitotic chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q90988-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q90YB1-1", "uniprot_id": [ { "id": "DNLI4_CHICK", "url": "https://www.uniprot.org/uniprot/Q90YB1", "type": "external" } ], "mass": 104450.0, "length": 912, "protein_name": "DNA ligase 4", "gene_name": "LIG4", "organism": "Chicken", "refseq_name": "DNA ligase 4", "refseq_ac": [ { "id": "NP_001025987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025987", "type": "external" } ], "gene_names_uniprotkb": "LIG4; RCJMB04_10b2", "gene_names_refseq": "LIG4", "protein_names_uniprotkb": "DNA ligase 4; 6.5.1.1; DNA ligase IV; Polydeoxyribonucleotide synthase [ATP] 4", "protein_names_refseq": "DNA ligase (ATP) 4; DNA ligase 4; DNA ligase IV; ligase IV, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 4", "tax_id": 9031, "disease": "", "pathway": " (gga:418764); (R-GGA-353423)", "pathway_count": 2, "publication_count": 8, "publication_id_list": "10757784;11593023;12509254;14561766;15642098;18046455;22529269;9736627", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: AJ720061.1 [ECO:0000345] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ720061.1. On Aug 8, 2005 this sequence version replaced XP_416960.1., [RefSeq]; DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps. Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5ZKM3", "ec_number_list": [ { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003910 DNA ligase (ATP) activity", "go_cellular_component": "GO:0070419 nonhomologous end joining complex;GO:0032807 DNA ligase IV complex;GO:0005654 nucleoplasm;GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex", "go_biological_process": "GO:0071897 DNA biosynthetic process;GO:0006297 nucleotide-excision repair, DNA gap filling;GO:0051301 cell division;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0033152 immunoglobulin V(D)J recombination", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q90YB1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91025-1", "uniprot_id": [ { "id": "VIT3_CHICK", "url": "https://www.uniprot.org/uniprot/Q91025", "type": "external" } ], "mass": 38151.0, "length": 347, "protein_name": "Vitellogenin-3", "gene_name": "VTG3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "VTG3; VTGIII", "gene_names_refseq": "", "protein_names_uniprotkb": "Vitellogenin-3; Minor vitellogenin; VYGIII; Vitellogenin III", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "2701940;2796998", "class_list": "", "function": "Phosvitin is believed to be of importance in sequestering calcium, iron and other cations for the developing embryo., [UniProtKB]; Precursor of the egg-yolk proteins that are sources of nutrients during early development of oviparous organisms., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q91028", "ec_number_list": [], "go_molecular_function": "GO:0005319 lipid transporter activity;GO:0045735 nutrient reservoir activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q91025-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91048-1", "uniprot_id": [ { "id": "PTK7_CHICK", "url": "https://www.uniprot.org/uniprot/Q91048", "type": "external" } ], "mass": 116366.0, "length": 1051, "protein_name": "Inactive tyrosine-protein kinase 7", "gene_name": "PTK7", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTK7; KLG", "gene_names_refseq": "", "protein_names_uniprotkb": "Inactive tyrosine-protein kinase 7; Kinase-like protein; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:421257)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1711213", "class_list": "", "function": "Inactive tyrosine kinase involved in the Wnt signaling pathway. Does not bind ATP., [UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008046 axon guidance receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0030424 axon;GO:0043025 neuronal cell body", "go_biological_process": "GO:0050808 synapse organization;GO:0016055 Wnt signaling pathway;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0060828 regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q91048-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91348-1", "uniprot_id": [ { "id": "F26L_CHICK", "url": "https://www.uniprot.org/uniprot/Q91348", "type": "external" } ], "mass": 54404.0, "length": 470, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; 6PF-2-K/Fru-2,6-P2ase liver isozyme; 6PF-2-K/Fru-2,6-P2ase; PFK/FBPase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-352875); (R-GGA-352882)", "pathway_count": 2, "publication_count": 17, "publication_id_list": "1593633;16287166;2110163;2985560;3094011;3539098;3885220;4463937;499525;6303388;6345546;6574503;7629021;7768978;7916593;8182283;9434147", "class_list": "", "function": "Synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9PWA7", "ec_number_list": [ { "id": "3.1.3.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.46", "type": "external" }, { "id": "2.7.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.105", "type": "external" } ], "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0003873 6-phosphofructo-2-kinase activity", "go_cellular_component": "GO:0043540 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex;GO:0005829 cytosol", "go_biological_process": "GO:0006000 fructose metabolic process;GO:0006003 fructose 2,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q91348-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q91974-1", "uniprot_id": [ { "id": "IKBA_CHICK", "url": "https://www.uniprot.org/uniprot/Q91974", "type": "external" } ], "mass": 35399.0, "length": 318, "protein_name": "NF-kappa-B inhibitor alpha", "gene_name": "NFKBIA", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NFKBIA; IKBA", "gene_names_refseq": "", "protein_names_uniprotkb": "NF-kappa-B inhibitor alpha; I-kappa-B-alpha; IkB-alpha; IkappaBalpha; REL-associated protein pp40", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1227892); (R-GGA-434001); (R-GGA-434131)", "pathway_count": 3, "publication_count": 17, "publication_id_list": "11057907;12221085;15145317;15371334;16056267;16115877;16153868;17047224;17135271;17332413;17496917;1891714;18984593;19479062;19666475;20097753;9689078", "class_list": "", "function": "Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1891714). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (By similarity)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051059 NF-kappaB binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0071345 cellular response to cytokine stimulus;GO:0048145 regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 1.8, "record_id": "Q91974-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q92076-1", "uniprot_id": [ { "id": "DPOG1_CHICK", "url": "https://www.uniprot.org/uniprot/Q92076", "type": "external" } ], "mass": 72855.0, "length": 647, "protein_name": "DNA polymerase subunit gamma-1", "gene_name": "POLG", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "POLG; POLG1", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA polymerase subunit gamma-1; 2.7.7.7; Mitochondrial DNA polymerase catalytic subunit", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8884268", "class_list": "", "function": "Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008408 3'-5' exonuclease activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid;GO:0005760 gamma DNA polymerase complex", "go_biological_process": "GO:0006298 mismatch repair;GO:0000731 DNA synthesis involved in DNA repair;GO:0006264 mitochondrial DNA replication;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q92076-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q92184-1", "uniprot_id": [ { "id": "SIA7B_CHICK", "url": "https://www.uniprot.org/uniprot/Q92184", "type": "external" } ], "mass": 45826.0, "length": 404, "protein_name": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2", "gene_name": "ST6GALNAC2", "organism": "Chicken", "refseq_name": "alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2", "refseq_ac": [ { "id": "NP_990564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990564", "type": "external" } ], "gene_names_uniprotkb": "ST6GALNAC2; SIAT7B", "gene_names_refseq": "ST6GALNAC2", "protein_names_uniprotkb": "Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; 2.4.3.3; Gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase; GalNAc alpha-2,6-sialyltransferase II; SIAT7-B; ST6GalNAc II; ST6GalNAcII; Sialyltransferase 7B", "protein_names_refseq": "Gal beta 1,3 GalNAc - specific GalNAc alpha 2,6-sialyltransferase; SIAT7-B; ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1, 3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc II; ST6GalNAcII; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; beta 1,3GalNAc-specific GalNAc alpha 2,6-sialyltransferase; gal-beta-1,3-GalNAc alpha-2,6-sialyltransferase; galNAc alpha-2,6-sialyltransferase II; sialyltransferase 7B", "tax_id": 9031, "disease": "", "pathway": " (gga:396159)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8034663", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267653.7084.1, SRR13267654.51586.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000316.1. On Oct 25, 2021 this sequence version replaced NP_990564.1., [RefSeq]; Catalyzes the transfer of N-acetylneuraminyl groups onto glycan chains in glycoproteins (PubMed:8034663). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins. Sialylates alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr epitopes also known as Tn and T antigens., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.3", "type": "external" } ], "go_molecular_function": "GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:1990743 protein sialylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q92184-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q98931-1", "uniprot_id": [ { "id": "LRP8_CHICK", "url": "https://www.uniprot.org/uniprot/Q98931", "type": "external" } ], "mass": 101379.0, "length": 917, "protein_name": "Low-density lipoprotein receptor-related protein 8", "gene_name": "LRP8", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LRP8; LR8B", "gene_names_refseq": "", "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 8; Apolipoprotein E receptor 2; LRP-8; Protein LR8B", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396102)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11294845;8662771", "class_list": "", "function": "Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. Also binds alpha2-macroglobulin. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q90883", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005901 caveola", "go_biological_process": "GO:0006897 endocytosis;GO:0021517 ventral spinal cord development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q98931-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q98932-1", "uniprot_id": [ { "id": "RAB5C_CHICK", "url": "https://www.uniprot.org/uniprot/Q98932", "type": "external" } ], "mass": 23554.0, "length": 216, "protein_name": "Ras-related protein Rab-5C", "gene_name": "RAB5C", "organism": "Chicken", "refseq_name": "ras-related protein Rab-5C", "refseq_ac": [ { "id": "NP_989856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989856", "type": "external" } ], "gene_names_uniprotkb": "RAB5C", "gene_names_refseq": "RAB5C", "protein_names_uniprotkb": "Ras-related protein Rab-5C; 3.6.5.2; Rab5C-like protein", "protein_names_refseq": "rab5C-like protein; ras-related protein Rab-5C", "tax_id": 9031, "disease": "", "pathway": " (gga:395197); (R-GGA-432722); (R-GGA-6798695); (R-GGA-8856828); (R-GGA-8876198)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "9602038", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y07811.1, BU129200.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992484, SAMN08016668 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Y07811.1., [RefSeq]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in early endocytic trafficking. Required for EEA1 recruitment to early endosomes. Required for EGF and transferrin endocytosis and trafficking through early endosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.1.3.86", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86", "type": "external" }, { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.17.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.22", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0012505 endomembrane system;GO:0031901 early endosome membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0016197 endosomal transport;GO:0048227 plasma membrane to endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q98932-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q98936-1", "uniprot_id": [ { "id": "PTPRG_CHICK", "url": "https://www.uniprot.org/uniprot/Q98936", "type": "external" } ], "mass": 159767.0, "length": 1422, "protein_name": "Receptor-type tyrosine-protein phosphatase gamma", "gene_name": "PTPRG", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTPRG", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase gamma; 3.1.3.48; Protein-tyrosine phosphatase gamma; R-PTP-gamma", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q98936-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q98953-1", "uniprot_id": [ { "id": "S10A6_CHICK", "url": "https://www.uniprot.org/uniprot/Q98953", "type": "external" } ], "mass": 10276.0, "length": 92, "protein_name": "Protein S100-A6", "gene_name": "S100A6", "organism": "Chicken", "refseq_name": "protein S100-A6", "refseq_ac": [ { "id": "NP_989479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989479", "type": "external" } ], "gene_names_uniprotkb": "S100A6", "gene_names_refseq": "S100A6", "protein_names_uniprotkb": "Protein S100-A6; Calcyclin; S100 calcium-binding protein A6", "protein_names_refseq": "calcyclin; protein S100-A6", "tax_id": 9031, "disease": "", "pathway": " (gga:373951)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "9599662", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CD737389.1, U76365.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992484, SAMEA103992639 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000349.1., [RefSeq]; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0051781 positive regulation of cell division", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q98953-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q98SH2-1", "uniprot_id": [ { "id": "AT2B1_CHICK", "url": "https://www.uniprot.org/uniprot/Q98SH2", "type": "external" } ], "mass": 133019.0, "length": 1205, "protein_name": "Plasma membrane calcium-transporting ATPase 1", "gene_name": "ATP2B1", "organism": "Chicken", "refseq_name": "plasma membrane calcium-transporting ATPase 1 isoform 2", "refseq_ac": [ { "id": "NP_001161474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161474", "type": "external" } ], "gene_names_uniprotkb": "ATP2B1; PMCA1", "gene_names_refseq": "ATP2B1", "protein_names_uniprotkb": "Plasma membrane calcium-transporting ATPase 1; 7.2.2.10; PMCA1; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium pump isoform 1", "protein_names_refseq": "ATPase, Ca++ transporting, plasma membrane 1; PMCA1; plasma membrane calcium ATPase; plasma membrane calcium pump; plasma membrane calcium-transporting ATPase 1 isoform 2; plasma membrane calcium-transporting ATPase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:374244); (R-GGA-418359); (R-GGA-5578775); (R-GGA-936837)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "15592404;7679502", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: partial sample support SAMEA103992290, SAMEA103992323 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Dec 3, 2021 this sequence version replaced NP_001161474.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytoplasm to the extracellular space thereby maintaining intracellular calcium homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PSV8;Q9PSK0", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q98SH2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q98ST7-1", "uniprot_id": [ { "id": "MOXD1_CHICK", "url": "https://www.uniprot.org/uniprot/Q98ST7", "type": "external" } ], "mass": 69503.0, "length": 614, "protein_name": "DBH-like monooxygenase protein 1", "gene_name": "MOXD1", "organism": "Chicken", "refseq_name": "DBH-like monooxygenase protein 1 precursor", "refseq_ac": [ { "id": "NP_989955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989955", "type": "external" } ], "gene_names_uniprotkb": "MOXD1; DBHR; MOX", "gene_names_refseq": "DBHR; MOXD1", "protein_names_uniprotkb": "DBH-like monooxygenase protein 1; 1.14.17.-; DBH-related protein; Monooxygenase X", "protein_names_refseq": "DBH-like monooxygenase protein 1 precursor; DBH-like monooxygenase protein 1; DBH-related protein; monooxygenase X", "tax_id": 9031, "disease": "", "pathway": " (gga:395333)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11397006;15337741", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF327450.1, SRR13267649.4891.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000063.1. On Sep 23, 2021 this sequence version replaced NP_989955.1., [RefSeq]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding;GO:0004500 dopamine beta-monooxygenase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005789 endoplasmic reticulum membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0042420 dopamine catabolic process;GO:0006589 octopamine biosynthetic process;GO:0042421 norepinephrine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q98ST7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q98T82-1", "uniprot_id": [ { "id": "Q98T82_CHICK", "url": "https://www.uniprot.org/uniprot/Q98T82", "type": "external" } ], "mass": 47532.0, "length": 462, "protein_name": "Early growth response 2", "gene_name": "LOC101748577", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC101748577", "gene_names_refseq": "", "protein_names_uniprotkb": "Early growth response 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5NX35", "ec_number_list": [], "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016925 protein sumoylation;GO:0045444 fat cell differentiation;GO:0035904 aorta development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q98T82-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q98TA4-1", "uniprot_id": [ { "id": "MBL_CHICK", "url": "https://www.uniprot.org/uniprot/Q98TA4", "type": "external" } ], "mass": 27396.0, "length": 254, "protein_name": "Mannose-binding protein", "gene_name": "MBL", "organism": "Chicken", "refseq_name": "mannose-binding lectin precursor", "refseq_ac": [ { "id": "NP_989680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989680", "type": "external" } ], "gene_names_uniprotkb": "MBL", "gene_names_refseq": "MBL2; MBL; MBP; cMBl; collectin", "protein_names_uniprotkb": "Mannose-binding protein; MBP; Mannan-binding protein", "protein_names_refseq": "MBL-C; c-type lectin; mannan-binding lectin; mannan-binding protein; mannose binding lectin, liver (A); mannose-binding lectin precursor; mannose-binding lectin protein; mannose-binding lectin; mannose-binding protein", "tax_id": 9031, "disease": "", "pathway": " (gga:374267); (R-GGA-2132263); (R-GGA-2132270)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "11003389;12743029;15034049;15060079;15199963;15592404;18596036;20032467;22691502;25721364;31238731;8409391;8576206", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF231714.1, KU378610.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN08016663 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000227.1. On Dec 3, 2021 this sequence version replaced NP_989680.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway., [UniProtKB, UniProtKB]; In chickens, six different collagenous lectins have been characterized so far: mannose-binding lectin (MBL), surfactant protein A (SP-A), collectin 10 (COLEC10), collectin 11 (COLEC11), collectin 12 (COLEC12), lung lectin (LL) and one ficolin (FCN)., [RefSeq, PubMed]; In the negative control birds, the spleen was mannose-binding lectin (MBL) negative, while the caecal tonsil showed scattered MBL-positive cells in close proximity and within the surface epithelium and germinal centre-like cell clusters. MBL was detectable in the ellipsoid-associated cells and cell clusters in the periarterial lymphoid sheath by 7 days post infection., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1NKG3", "ec_number_list": [], "go_molecular_function": "GO:0005537 D-mannose binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005771 multivesicular body", "go_biological_process": "GO:0043129 surfactant homeostasis;GO:0050766 positive regulation of phagocytosis;GO:0001867 complement activation, lectin pathway;GO:0006958 complement activation, classical pathway", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q98TA4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q98TX3-1", "uniprot_id": [ { "id": "PDCD4_CHICK", "url": "https://www.uniprot.org/uniprot/Q98TX3", "type": "external" } ], "mass": 51708.0, "length": 467, "protein_name": "Programmed cell death protein 4", "gene_name": "PDCD4", "organism": "Chicken", "refseq_name": "programmed cell death protein 4 isoform 1", "refseq_ac": [ { "id": "NP_989635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989635", "type": "external" } ], "gene_names_uniprotkb": "PDCD4", "gene_names_refseq": "PDCD4", "protein_names_uniprotkb": "Programmed cell death protein 4; Protein I11/6", "protein_names_refseq": "programmed cell death 4 (neoplastic transformation inhibitor); programmed cell death protein 4 isoform 1; programmed cell death protein 4; protein I11/6", "tax_id": 9031, "disease": "", "pathway": " (gga:374191)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "11313950;19684621;21643008;24681950", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888544.177657.1, SRR13267655.116801.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000232.1. On Dec 8, 2021 this sequence version replaced NP_989635.1., [RefSeq]; C-myb mRNA as the first natural translational target mRNA of Pdcd4, [RefSeq, PubMed]; Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A and EIF4G. Inhibits the helicase activity of EIF4A. Binds RNA (By similarity). Does not seem to be involved in apoptosis., [UniProtKB, PubMed]; Pdcd4 has an important function in the cellular response to DNA damage, [RefSeq, PubMed]; This work reveals a novel mechanism by which Pdcd4 affects the translation of cellular RNAs., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:0043508 negative regulation of JUN kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q98TX3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DE07-1", "uniprot_id": [ { "id": "NBN_CHICK", "url": "https://www.uniprot.org/uniprot/Q9DE07", "type": "external" } ], "mass": 83987.0, "length": 753, "protein_name": "Nibrin", "gene_name": "NBN", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NBN; NBS1", "gene_names_refseq": "", "protein_names_uniprotkb": "Nibrin; Nijmegen breakage syndrome protein 1 homolog", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:374246); (R-GGA-217106); (R-GGA-351433); (R-GGA-351442); (R-GGA-351444)", "pathway_count": 5, "publication_count": 10, "publication_id_list": "11062235;12422221;15059890;15066121;15311285;15800615;17123873;17468739;17515904;9008167", "class_list": "", "function": "Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:12422221). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (By similarity). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (By similarity). The MRN complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11, to initiate end resection, which is required for single-strand invasion and recombination (By similarity). Within the MRN complex, NBN acts as a protein-protein adapter, which specifically recognizes and binds phosphorylated proteins, promoting their recruitment to DNA damage sites (By similarity). Recruits MRE11 and RAD50 components of the MRN complex to DSBs in response to DNA damage (By similarity). Promotes the recruitment of PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites, activating their functions (By similarity). Mediates the recruitment of phosphorylated RBBP8/CtIP to DSBs, leading to cooperation between the MRN complex and RBBP8/CtIP to initiate end resection (By similarity). The MRN complex and rbbp8/CtIP are also required for chromosome alignment during metaphase (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding;GO:0043539 protein serine/threonine kinase activator activity;GO:0140031 phosphorylation-dependent protein binding;GO:0140463 chromatin-protein adaptor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016605 PML body;GO:0035861 site of double-strand break;GO:0042405 nuclear inclusion body;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0043247 telomere maintenance in response to DNA damage;GO:0000723 telomere maintenance;GO:0031848 protection from non-homologous end joining at telomere;GO:0006302 double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q9DE07-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DEA3-1", "uniprot_id": [ { "id": "PCNA_CHICK", "url": "https://www.uniprot.org/uniprot/Q9DEA3", "type": "external" } ], "mass": 28888.0, "length": 262, "protein_name": "DNA sliding clamp PCNA", "gene_name": "PCNA", "organism": "Chicken", "refseq_name": "DNA sliding clamp PCNA", "refseq_ac": [ { "id": "NP_989501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989501", "type": "external" } ], "gene_names_uniprotkb": "PCNA", "gene_names_refseq": "PCNA", "protein_names_uniprotkb": "DNA sliding clamp PCNA; PCNA; Proliferating cell nuclear antigen", "protein_names_refseq": "DNA sliding clamp PCNA", "tax_id": 9031, "disease": "", "pathway": " (gga:373984); (R-GGA-353299); (R-GGA-353303)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11453553;12773817;15572677;15642098;17065558;1764072;28458162;9302295", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01002773.1, HAEL01000007.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000331.1., [RefSeq]; Confers DNA tethering and processivity to DNA polymerases and other proteins. Auxiliary protein of DNA polymerase delta and epsilon, is involved in the control of DNA replication by increasing the polymerases' processivity during elongation of the leading strand., [UniProtKB, UniProtKB]; No requirement for PCNA polyubiquitylation to protect cells from replication-stalling DNA damage was found, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030337 DNA polymerase processivity factor activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0019899 enzyme binding", "go_cellular_component": "GO:0043626 PCNA complex;GO:0070557 PCNA-p21 complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006272 leading strand elongation;GO:0006298 mismatch repair;GO:0006275 regulation of DNA replication;GO:0019985 translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9DEA3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DER7-1", "uniprot_id": [ { "id": "TLL1_CHICK", "url": "https://www.uniprot.org/uniprot/Q9DER7", "type": "external" } ], "mass": 114891.0, "length": 1008, "protein_name": "Tolloid-like protein 1", "gene_name": "TLL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TLL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Tolloid-like protein 1; 3.4.24.-; Chicken tolloid-like protein 1; Metalloprotease colloid", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10940628", "class_list": "", "function": "Protease which processes procollagen C-propeptides, such as chordin, probiglycan and prolysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 5, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0016485 protein processing;GO:0030154 cell differentiation;GO:0009953 dorsal/ventral pattern formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DER7-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9DGB6-1", "uniprot_id": [ { "id": "TLR22_CHICK", "url": "https://www.uniprot.org/uniprot/Q9DGB6", "type": "external" } ], "mass": 89095.0, "length": 781, "protein_name": "Toll-like receptor 2 type-2", "gene_name": "TLR2-2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TLR2-2", "gene_names_refseq": "", "protein_names_uniprotkb": "Toll-like receptor 2 type-2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:769014); (R-GGA-1461957); (R-GGA-5686938); (R-GGA-6798695)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "11590137", "class_list": "", "function": "Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2)., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042497 triacyl lipopeptide binding;GO:0004888 transmembrane signaling receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0042494 detection of bacterial lipoprotein;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0002224 toll-like receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9DGB6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I8D8-1", "uniprot_id": [ { "id": "CD40L_CHICK", "url": "https://www.uniprot.org/uniprot/Q9I8D8", "type": "external" } ], "mass": 30833.0, "length": 272, "protein_name": "CD40 ligand", "gene_name": "CD40LG", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CD40LG; CD40L; TNFSF5", "gene_names_refseq": "", "protein_names_uniprotkb": "CD40 ligand; CD40-L; Tumor necrosis factor ligand superfamily member 5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395485)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling., [UniProtKB, UniProtKB]; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005174 CD40 receptor binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0030168 platelet activation;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9I8D8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I8Q3-1", "uniprot_id": [ { "id": "CFC1_CHICK", "url": "https://www.uniprot.org/uniprot/Q9I8Q3", "type": "external" } ], "mass": 22332.0, "length": 193, "protein_name": "Cryptic protein", "gene_name": "CFC1", "organism": "Chicken", "refseq_name": "cryptic protein precursor", "refseq_ac": [ { "id": "NP_990031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990031", "type": "external" } ], "gene_names_uniprotkb": "CFC1", "gene_names_refseq": "CFC1B; CFC1", "protein_names_uniprotkb": "Cryptic protein; Cripto-related factor 1", "protein_names_refseq": "CRIPTO-related factor 1; chick-cripto; cripto, FRL-1, cryptic family 1B; cryptic protein precursor; cryptic protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395437)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11024280", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF228760.1, HAEL01000614.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000094.1., [RefSeq]; May play a role in mesoderm and/or neural patterning during gastrulation., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038100 nodal binding;GO:0070697 activin receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0098552 side of membrane", "go_biological_process": "GO:0007507 heart development;GO:0001568 blood vessel development;GO:0009952 anterior/posterior pattern specification;GO:0038092 nodal signaling pathway;GO:0007368 determination of left/right symmetry", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9I8Q3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I969-1", "uniprot_id": [ { "id": "TXLNB_CHICK", "url": "https://www.uniprot.org/uniprot/Q9I969", "type": "external" } ], "mass": 77021.0, "length": 676, "protein_name": "Beta-taxilin", "gene_name": "TXLNB", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TXLNB; MDP77", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-taxilin; Muscle-derived protein 77", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395515)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10708594;12372618", "class_list": "", "function": "Promotes neurite-outgrowth. May be involved in intracellular vesicle traffic., [UniProtKB, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030017 sarcomere", "go_biological_process": "GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9I969-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I9K9-1", "uniprot_id": [ { "id": "GATM_CHICK", "url": "https://www.uniprot.org/uniprot/Q9I9K9", "type": "external" } ], "mass": 48311.0, "length": 422, "protein_name": "Glycine amidinotransferase, mitochondrial", "gene_name": "GATM", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GATM; AT", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycine amidinotransferase, mitochondrial; 2.1.4.1; L-arginine:glycine amidinotransferase; Transamidinase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395504)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11506177;12445392", "class_list": "", "function": "Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.4.1", "type": "external" } ], "go_molecular_function": "GO:0015068 glycine amidinotransferase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space", "go_biological_process": "GO:0006601 creatine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9I9K9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9I9R0-1", "uniprot_id": [ { "id": "HABP4_CHICK", "url": "https://www.uniprot.org/uniprot/Q9I9R0", "type": "external" } ], "mass": 39968.0, "length": 357, "protein_name": "Intracellular hyaluronan-binding protein 4", "gene_name": "HABP4", "organism": "Chicken", "refseq_name": "intracellular hyaluronan-binding protein 4", "refseq_ac": [ { "id": "NP_990036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990036", "type": "external" } ], "gene_names_uniprotkb": "HABP4", "gene_names_refseq": "HABP4", "protein_names_uniprotkb": "Intracellular hyaluronan-binding protein 4; IHABP4", "protein_names_refseq": "IHABP4; intracellular hyaluronan-binding protein 4; intracellular hyaluronan-binding protein p57", "tax_id": 9031, "disease": "", "pathway": " (gga:395444)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10887182", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01020275.1, AF227683.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000094.1., [RefSeq]; Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor at the A-site of the ribosome, promoting ribosome stabilization in an inactive state compatible with storage (By similarity). Plays a key role in ribosome hibernation in the mature egg by promoting ribosome stabilization (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the egg and early embryo (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0061770 translation elongation factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0015030 Cajal body", "go_biological_process": "GO:0033120 positive regulation of RNA splicing;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0045948 positive regulation of translational initiation;GO:0141014 ribosome hibernation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9I9R0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9IA06-1", "uniprot_id": [ { "id": "FZD2_CHICK", "url": "https://www.uniprot.org/uniprot/Q9IA06", "type": "external" } ], "mass": 59281.0, "length": 523, "protein_name": "Frizzled-2", "gene_name": "FZD2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FZD2; FZ2", "gene_names_refseq": "", "protein_names_uniprotkb": "Frizzled-2; Fz-2; cFz-2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "10512196;10781956;25759469", "class_list": "", "function": "Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q9PTW4", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0017147 Wnt-protein binding;GO:0042813 Wnt receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0060070 canonical Wnt signaling pathway;GO:0035567 non-canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9IA06-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9IA31-1", "uniprot_id": [ { "id": "GLI3_CHICK", "url": "https://www.uniprot.org/uniprot/Q9IA31", "type": "external" } ], "mass": 167791.0, "length": 1544, "protein_name": "Transcription activator GLI3", "gene_name": "GLI3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GLI3", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription activator GLI3; GLI3 C-terminally truncated form; GLI3 full-length protein; GLI3FL", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:420769)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10693759", "class_list": "", "function": "Major transcription repressor, which inhibits expression of target genes in the absence of smoothened (SMO) signaling (By similarity). Generated by proteolytic processing of the full-length GLI3 form in the absence of hedgehog (DHH, IHH or SHH), when SMO transducer is inhibited (By similarity). Constitutes the major form of GLI3, while the transcription activator form only plays a minor role (By similarity)., [UniProtKB, UniProtKB]; Transcription factor that acts as a key effector of the smoothened signaling pathway, and which plays a role in the development and patterning of various body structures, including the brain and limbs (PubMed:10693759). Specifically binds to the minimal GLI-consensus sequence 5'-GACCACCCA-3' to activate or repress the expression of target genes (By similarity). Functions both as a transcriptional activator and repressor: the full-length GLI3 form (Transcription activator GLI3) acts as a transcription activator following smoothened activation, while the Transcription repressor GLI3R, which is generated in absence of smoothened, acts as a transcription repressor (By similarity). The repressor form (GLI3R) constitutes the major form of GLI3 (By similarity)., [UniProtKB, PubMed, UniProtKB]; Transcription factor, which activates expression of target genes in response to smoothened (SMO) activation (By similarity). Constitutes a minor form of GLI3, while the transcription repressor form (GLI3R) plays a major role (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0060173 limb development;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9IA31-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9IAL1-1", "uniprot_id": [ { "id": "VSX2_CHICK", "url": "https://www.uniprot.org/uniprot/Q9IAL1", "type": "external" } ], "mass": 40645.0, "length": 377, "protein_name": "Visual system homeobox 2", "gene_name": "VSX2", "organism": "Chicken", "refseq_name": "visual system homeobox 2", "refseq_ac": [ { "id": "NP_990099", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990099", "type": "external" } ], "gene_names_uniprotkb": "VSX2; CHX10", "gene_names_refseq": "CHX10; VSX2", "protein_names_uniprotkb": "Visual system homeobox 2; Ceh-10 homeodomain-containing homolog; Homeobox protein CHX10", "protein_names_refseq": "ceh-10 homeo domain containing homolog; ceh-10 homeodomain containing homolog; homeobox protein Chx10; visual system homeobox 2", "tax_id": 9031, "disease": "", "pathway": " (gga:395536)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10640715;15647262;15893976;16236706;27001188;27477290", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF178671.1, SRR13267659.198103.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF178671.1., [RefSeq]; Acts as a transcriptional regulator (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex (PubMed:27477290). May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity)., [UniProtKB, PubMed, UniProtKB]; CHX10 and VSX1 may control retinal bipolar cell specification or differentiation by repressing genes required for the development of other cell types, [RefSeq, PubMed]; CHX10 may target specific motifs to inhibit rod photoreceptor gene expression in bipolar cells, [RefSeq, PubMed]; Chx10 can function as a cell autonomous regulator of the regional identity in the primordial retina, presumably through a downstream transcriptional cascade, [RefSeq, PubMed]; Chx10 expression in subsets of retinal progenitor cells and bipolar ells requires a POU factor binding site upstream of the Chx10 gene, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q9IAL1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9IAM7-1", "uniprot_id": [ { "id": "MRE11_CHICK", "url": "https://www.uniprot.org/uniprot/Q9IAM7", "type": "external" } ], "mass": 80024.0, "length": 700, "protein_name": "Double-strand break repair protein MRE11", "gene_name": "MRE11", "organism": "Chicken", "refseq_name": "double-strand break repair protein MRE11", "refseq_ac": [ { "id": "NP_990109", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990109", "type": "external" } ], "gene_names_uniprotkb": "MRE11", "gene_names_refseq": "MRE11A; MRE11", "protein_names_uniprotkb": "Double-strand break repair protein MRE11; 3.1.-.-", "protein_names_refseq": "MRE11 homolog A, double strand break repair nuclease; MRE11 meiotic recombination 11 homolog A; double-strand break repair protein MRE11", "tax_id": 9031, "disease": "", "pathway": " (gga:395555); (R-GGA-217106); (R-GGA-351433); (R-GGA-351442); (R-GGA-351444)", "pathway_count": 5, "publication_count": 13, "publication_id_list": "10581236;11062235;12422221;15059890;15066121;15311285;15800615;17123873;17468739;17515904;27311583;27814490;9008167", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267661.28350.1, SRR13267656.3569.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000027.1. On or before Dec 3, 2021 this sequence version replaced XP_015135386.2, NP_990109.1., [RefSeq]; Although Mre11 is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines., [RefSeq, PubMed]; Both the genome instability and cell death of MRE11-null and MRE11-mutated H129N cells are significantly reversed by overexpression of Tdp2, an enzyme that eliminates covalent Top2 conjugates; thus, the essential role of Mre11 nuclease activity is likely to remove the DNA lesions. Erratum:[Mol Cell. 2016 Dec 1;64(5):1010. doi: 10.1016/j.molcel.2016.11.028. PMID: 27912094], [RefSeq, PubMed]; Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (By similarity). The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases (By similarity). The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage (By similarity). Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity (By similarity). After DSBs, MRE11 is loaded onto DSBs sites and cleaves DNA by cooperating with RBBP8/CtIP to initiate end resection (By similarity). MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR (By similarity). It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation to create entry sites for EXO1- and DNA2-mediated 5' to 3' long-range resection, which is required for single-strand invasion and recombination (By similarity). RBBP8/CtIP specifically promotes the endonuclease activity of MRE11 to clear protein-DNA adducts and generate clean double-strand break ends (By similarity). The MRN complex is also required for DNA damage signaling via activation of the ATM and ATR kinases: the nuclease activity of MRE11 is not required to activate ATM and ATR (By similarity). In telomeres the MRN complex may modulate t-loop formation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0030145 manganese ion binding;GO:0004520 DNA endonuclease activity;GO:0008408 3'-5' exonuclease activity;GO:0000014 single-stranded DNA endodeoxyribonuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0005657 replication fork;GO:0000781 chromosome, telomeric region;GO:0030870 Mre11 complex", "go_biological_process": "GO:0000723 telomere maintenance;GO:0006974 DNA damage response;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0000724 double-strand break repair via homologous recombination;GO:0031573 mitotic intra-S DNA damage checkpoint signaling", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9IAM7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9IAY5-1", "uniprot_id": [ { "id": "TIRR_CHICK", "url": "https://www.uniprot.org/uniprot/Q9IAY5", "type": "external" } ], "mass": 33296.0, "length": 314, "protein_name": "Tudor-interacting repair regulator protein", "gene_name": "NUDT16L1", "organism": "Chicken", "refseq_name": "tudor-interacting repair regulator protein", "refseq_ac": [ { "id": "NP_990111", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990111", "type": "external" } ], "gene_names_uniprotkb": "NUDT16L1; SDOS; TIRR", "gene_names_refseq": "NUDT16L1; SDOS", "protein_names_uniprotkb": "Tudor-interacting repair regulator protein; NUDT16-like protein 1; Protein syndesmos", "protein_names_refseq": "NUDT16-like protein 1; nudix (nucleoside diphosphate linked moiety X)-type motif 16-like 1; protein syndesmos; syndesmos; tudor-interacting repair regulator protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395557)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10633082", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01085405.1, HAEL01010113.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992470, SAMEA103992533 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000257.1., [RefSeq]; Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030515 snoRNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9IAY5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PSX7-1", "uniprot_id": [ { "id": "RHOC_CHICK", "url": "https://www.uniprot.org/uniprot/Q9PSX7", "type": "external" } ], "mass": 21973.0, "length": 193, "protein_name": "Rho-related GTP-binding protein RhoC", "gene_name": "RHOC", "organism": "Chicken", "refseq_name": "rho-related GTP-binding protein RhoC", "refseq_ac": [ { "id": "NP_001025020", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025020", "type": "external" } ], "gene_names_uniprotkb": "RHOC; ARHC", "gene_names_refseq": "ARHC; CRHOC; RHOC", "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoC; 3.6.5.2", "protein_names_refseq": "GTP-binding protein; GTPase cRhoC; ras homolog gene family, member C; rho-related GTP-binding protein RhoC", "tax_id": 9031, "disease": "", "pathway": " (gga:395869)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "17208217;18612635;25860507;9811589", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01017598.1, HAEK01119736.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000356.1. On Jul 27, 2005 this sequence version replaced XP_425828.1., [RefSeq]; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells (By similarity)., [UniProtKB]; RhoC is a negative regulator of chondrogenesis, which controls digit outgrowth and joint segmentation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032154 cleavage furrow", "go_biological_process": "GO:0043297 apical junction assembly;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0016477 cell migration;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9PSX7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PT84-1", "uniprot_id": [ { "id": "KCNH6_CHICK", "url": "https://www.uniprot.org/uniprot/Q9PT84", "type": "external" } ], "mass": 135501.0, "length": 1202, "protein_name": "Voltage-gated inwardly rectifying potassium channel KCNH6", "gene_name": "KCNH6", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KCNH6; ERG", "gene_names_refseq": "", "protein_names_uniprotkb": "Voltage-gated inwardly rectifying potassium channel KCNH6; ERG; Eag-related protein; Ether-a-go-go-related gene potassium channel; Ether-a-go-go-related protein; Potassium voltage-gated channel subfamily H member 6; Voltage-gated potassium channel subunit Kv11.2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10906470;15592404", "class_list": "", "function": "Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Activates even more slowly than KCNH2., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1NBY6", "ec_number_list": [], "go_molecular_function": "GO:0005242 inward rectifier potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0086013 membrane repolarization during cardiac muscle cell action potential;GO:0086091 regulation of heart rate by cardiac conduction;GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9PT84-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PTJ6-1", "uniprot_id": [ { "id": "CTDSL_CHICK", "url": "https://www.uniprot.org/uniprot/Q9PTJ6", "type": "external" } ], "mass": 31244.0, "length": 275, "protein_name": "CTD small phosphatase-like protein", "gene_name": "NFI1", "organism": "Chicken", "refseq_name": "CTD small phosphatase-like protein", "refseq_ac": [ { "id": "NP_001001316", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001316", "type": "external" } ], "gene_names_uniprotkb": "NFI1; NIF", "gene_names_refseq": "CTDSPL; NFI1; NIF", "protein_names_uniprotkb": "CTD small phosphatase-like protein; 3.1.3.16; CTDSP-like; NLI-interacting factor 1; Nuclear LIM interactor-interacting factor 1; Small C-terminal domain phosphatase 3", "protein_names_refseq": "CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; CTD small phosphatase-like protein; CTDSP-like; NLI-interacting factor 1; NLI/Ldb1/CLIM interacting factor; nuclear LIM interactor-interacting factor 1; small C-terminal domain phosphatase 3", "tax_id": 9031, "disease": "", "pathway": " (gga:408252)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267652.22568.1, SRR13267649.143630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000035.1. On Aug 30, 2004 this sequence version replaced XP_418520.1., [RefSeq]; Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9PTJ7;Q9PTJ8;Q9PTJ9", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9PTJ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PTQ7-1", "uniprot_id": [ { "id": "DMRT1_CHICK", "url": "https://www.uniprot.org/uniprot/Q9PTQ7", "type": "external" } ], "mass": 38836.0, "length": 365, "protein_name": "Doublesex- and mab-3-related transcription factor 1", "gene_name": "DMRT1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DMRT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "10080173;10545231;10965136;15592404;19710650", "class_list": "", "function": "Transcription factor that plays a key role in male sex determination. Acts both as a transcription repressor and repressor., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "D3Y4D9;E9LT10;F1N8U8;Q9PTB5", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0007548 sex differentiation;GO:0072520 seminiferous tubule development", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9PTQ7-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PTU5-1", "uniprot_id": [ { "id": "ESR2_CHICK", "url": "https://www.uniprot.org/uniprot/Q9PTU5", "type": "external" } ], "mass": 53439.0, "length": 472, "protein_name": "Estrogen receptor beta", "gene_name": "ESR2", "organism": "Chicken", "refseq_name": "estrogen receptor beta", "refseq_ac": [ { "id": "NP_990125", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990125", "type": "external" } ], "gene_names_uniprotkb": "ESR2; NR3A2", "gene_names_refseq": "CERB; ESR2", "protein_names_uniprotkb": "Estrogen receptor beta; ER-beta; Nuclear receptor subfamily 3 group A member 2; cERb", "protein_names_refseq": "ER-beta; estrogen receptor 2 (ER beta); estrogen receptor beta; nuclear receptor subfamily 3 group A member 2", "tax_id": 9031, "disease": "", "pathway": " (gga:395575)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "20043933;23103859;23342917;29666334;29772405", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB036415.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000215.1. On Oct 17, 2021 this sequence version replaced NP_990125.1., [RefSeq]; Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner., [UniProtKB, UniProtKB]; Changes in ERbeta level suggest that this form of estrogen receptor plays a predominant role for estrogen action in the chicken adrenal gland during stress., [RefSeq, PubMed]; Data show that hepatocellular carcinoma LMH cells transfected with a reporter construct bearing the vitellogenin promoter is a useful model for the study of hydrocarbon receptor (AHR)-estrogen receptor (ER) interaction in liver-derived cells., [RefSeq, PubMed]; ESR2 is a potential regulator of CYP19A1 expression in the theca cells of chicken follicles., [RefSeq, PubMed]; Results describe the efects of daidzein, alone or in combination with estrogen, on estrogen receptor alpha and/or beta-mediated transactivation and on chicken hepatic vitellogenin II expression., [RefSeq, PubMed]; The expression of cathepsin E-A-like was regulated by oestrogen, and the regulative effect was predominantly mediated through ER-Beta in liver of chicken., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0008270 zinc ion binding;GO:0005496 steroid binding;GO:0004879 nuclear receptor activity;GO:0030284 nuclear estrogen receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0071392 cellular response to estradiol stimulus;GO:0030520 estrogen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9PTU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PU36-1", "uniprot_id": [ { "id": "PCLO_CHICK", "url": "https://www.uniprot.org/uniprot/Q9PU36", "type": "external" } ], "mass": 560764.0, "length": 5120, "protein_name": "Protein piccolo", "gene_name": "PCLO", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PCLO; ACZ", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein piccolo; Aczonin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10508862", "class_list": "", "function": "May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 0, "predicted_o_glycosites": 6, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098882 structural constituent of presynaptic active zone;GO:0008270 zinc ion binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0030424 axon;GO:0045202 synapse;GO:0048788 cytoskeleton of presynaptic active zone", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0035418 protein localization to synapse;GO:1904071 presynaptic active zone assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9PU36-1", "record_type": "protein", "filter_code": "0000000.0000100.000100.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PUB4-1", "uniprot_id": [ { "id": "CP26A_CHICK", "url": "https://www.uniprot.org/uniprot/Q9PUB4", "type": "external" } ], "mass": 55265.0, "length": 492, "protein_name": "Cytochrome P450 26A1", "gene_name": "CYP26A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CYP26A1; CYP26", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytochrome P450 26A1; 1.14.13.-; CYP26A1; Retinoic acid-degrading enzyme CYP26", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:408183)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10588879", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (PubMed:10588879). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (By similarity). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (By similarity) (PubMed:10588879). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (By similarity). Involved in the convertion of atRA to all-trans-4-oxo-RA. Able to metabolize other RAs such as 9-cis, 13-cis and 9,13-di-cis RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9PUG2", "ec_number_list": [ { "id": "1.14.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.-", "type": "external" } ], "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0004497 monooxygenase activity;GO:0062183 all-trans retinoic acid 18-hydroxylase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007417 central nervous system development;GO:0034653 retinoic acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9PUB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PUU8-1", "uniprot_id": [ { "id": "CNMD_CHICK", "url": "https://www.uniprot.org/uniprot/Q9PUU8", "type": "external" } ], "mass": 38636.0, "length": 347, "protein_name": "Leukocyte cell-derived chemotaxin 1", "gene_name": "CNMD", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CNMD; CHMI; LECT1", "gene_names_refseq": "", "protein_names_uniprotkb": "Leukocyte cell-derived chemotaxin 1; ChM-I; Chondromodulin-I; Chondromodulin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395600)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10452551;10590475;18612635", "class_list": "", "function": "Bifunctional growth regulator. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9YI63", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0012505 endomembrane system", "go_biological_process": "GO:0030154 cell differentiation;GO:0001937 negative regulation of endothelial cell proliferation;GO:0016525 negative regulation of angiogenesis;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9PUU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PW71-1", "uniprot_id": [ { "id": "DUS4_CHICK", "url": "https://www.uniprot.org/uniprot/Q9PW71", "type": "external" } ], "mass": 41052.0, "length": 375, "protein_name": "Dual specificity protein phosphatase 4", "gene_name": "DUSP4", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DUSP4; MKP2", "gene_names_refseq": "", "protein_names_uniprotkb": "Dual specificity protein phosphatase 4; 3.1.3.16; 3.1.3.48; MAP kinase phosphatase 2; MKP-2; Mitogen-activated protein kinase phosphatase 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395642); (R-GGA-437980); (R-GGA-437986)", "pathway_count": 3, "publication_count": 13, "publication_id_list": "10918612;12193592;13130464;15287722;15837794;16186825;17255097;17395714;17875933;18793328;8533096;8846784;9195981", "class_list": "", "function": "Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" } ], "go_molecular_function": "GO:1990439 MAP kinase serine/threonine phosphatase activity;GO:0004721 phosphoprotein phosphatase activity;GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0016791 phosphatase activity;GO:0008330 protein tyrosine/threonine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0016311 dephosphorylation;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0001706 endoderm formation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q9PW71-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9PWI7-1", "uniprot_id": [ { "id": "Q9PWI7_CHICK", "url": "https://www.uniprot.org/uniprot/Q9PWI7", "type": "external" } ], "mass": 53011.0, "length": 466, "protein_name": "Steroidogenic factor 1", "gene_name": "NR5A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NR5A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Steroidogenic factor 1; Nuclear receptor subfamily 5 group A member 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395960); (R-GGA-383280); (R-GGA-4090294)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005543 phospholipid binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:2000020 positive regulation of male gonad development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q9PWI7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W6U8-1", "uniprot_id": [ { "id": "MEF2A_CHICK", "url": "https://www.uniprot.org/uniprot/Q9W6U8", "type": "external" } ], "mass": 53669.0, "length": 499, "protein_name": "Myocyte-specific enhancer factor 2A", "gene_name": "MEF2A", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MEF2A", "gene_names_refseq": "", "protein_names_uniprotkb": "Myocyte-specific enhancer factor 2A", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "10370120", "class_list": "", "function": "Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Mediates cellular functions in skeletal and cardiac muscle development,., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9W6U8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W7I5-1", "uniprot_id": [ { "id": "RBBP4_CHICK", "url": "https://www.uniprot.org/uniprot/Q9W7I5", "type": "external" } ], "mass": 47607.0, "length": 425, "protein_name": "Histone-binding protein RBBP4", "gene_name": "RBBP4", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RBBP4; RBAP48", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone-binding protein RBBP4; CAF-1 subunit C; CAF-I 48 kDa subunit; CAF-I p48; Chromatin assembly factor 1 subunit C; Chromatin assembly factor I p48 subunit; RBBP-4; Retinoblastoma-binding protein 4; Retinoblastoma-binding protein p48; chCAF-1 p48", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395658)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10347232;11112423;11160883;15527972;17065558", "class_list": "", "function": "Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (By similarity). Component of several complexes which regulate chromatin metabolism (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex;GO:0033186 CAF-1 complex;GO:0000781 chromosome, telomeric region;GO:0016581 NuRD complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q9W7I5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W7R5-1", "uniprot_id": [ { "id": "SOX21_CHICK", "url": "https://www.uniprot.org/uniprot/Q9W7R5", "type": "external" } ], "mass": 28796.0, "length": 280, "protein_name": "Transcription factor SOX-21", "gene_name": "SOX21", "organism": "Chicken", "refseq_name": "sRY-related protein CH31", "refseq_ac": [ { "id": "NP_001383603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383603", "type": "external" } ], "gene_names_uniprotkb": "SOX21", "gene_names_refseq": "CH31; SOX21", "protein_names_uniprotkb": "Transcription factor SOX-21", "protein_names_refseq": "Transcription factor SOX-21; sRY-related protein CH31", "tax_id": 9031, "disease": "", "pathway": " (gga:107051027)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10473124", "class_list": "", "function": "Acts as a negative regulator of transcription., [UniProtKB, PubMed]; INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from JAENSK010000025.1. On or before Oct 25, 2021 this sequence version replaced XP_015130211.1, XP_040516235.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0042472 inner ear morphogenesis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9W7R5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9W7R6-1", "uniprot_id": [ { "id": "SOX14_CHICK", "url": "https://www.uniprot.org/uniprot/Q9W7R6", "type": "external" } ], "mass": 26666.0, "length": 240, "protein_name": "Transcription factor SOX-14", "gene_name": "SOX14", "organism": "Chicken", "refseq_name": "transcription factor SOX-14", "refseq_ac": [ { "id": "NP_990092", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990092", "type": "external" } ], "gene_names_uniprotkb": "SOX14", "gene_names_refseq": "CH60; SOX14", "protein_names_uniprotkb": "Transcription factor SOX-14; SRY-related protein CH60", "protein_names_refseq": "HMG box transcription factor SOX14; SRY (sex determining region Y)-box 14; SRY-related protein CH60; transcription factor SOX-14", "tax_id": 9031, "disease": "", "pathway": " (gga:395526)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10473124;10677261;8443573", "class_list": "", "function": "Acts as a negative regulator of transcription., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P40672", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q9W7R6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9YGI5-1", "uniprot_id": [ { "id": "DNAS1_CHICK", "url": "https://www.uniprot.org/uniprot/Q9YGI5", "type": "external" } ], "mass": 31400.0, "length": 282, "protein_name": "Deoxyribonuclease-1", "gene_name": "DNASE1", "organism": "Chicken", "refseq_name": "deoxyribonuclease-1 precursor", "refseq_ac": [ { "id": "NP_001384285", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001384285", "type": "external" } ], "gene_names_uniprotkb": "DNASE1", "gene_names_refseq": "DNASE1; deoxyribonuclease-1", "protein_names_uniprotkb": "Deoxyribonuclease-1; 3.1.21.1; DNase I; Deoxyribonuclease I", "protein_names_refseq": "deoxyribonuclease I-like 2; deoxyribonuclease-1 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:395725)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "12739897", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ131751.1, CR390356.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05341171 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1, AJ131751.1, BX267762.4 and BX267761.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:12739897). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By similarity). Among other functions, seems to be involved in cell death by apoptosis (By similarity). Binds specifically to G-actin and blocks actin polymerization (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003779 actin binding;GO:0004530 deoxyribonuclease I activity", "go_cellular_component": "GO:0042588 zymogen granule;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005635 nuclear envelope", "go_biological_process": "GO:0002283 neutrophil activation involved in immune response;GO:0070948 regulation of neutrophil mediated cytotoxicity;GO:0006915 apoptotic process;GO:0006308 DNA catabolic process;GO:0002673 regulation of acute inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q9YGI5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9YGL9-2", "uniprot_id": [ { "id": "AT2A3_CHICK", "url": "https://www.uniprot.org/uniprot/Q9YGL9", "type": "external" } ], "mass": 110546.0, "length": 999, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 3", "gene_name": "ATP2A3", "organism": "Chicken", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 3", "refseq_ac": [ { "id": "NP_990222", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990222", "type": "external" } ], "gene_names_uniprotkb": "ATP2A3", "gene_names_refseq": "ATP2A3; SERCA", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 3; 7.2.2.10; Calcium pump 3; ChkSERCA3; SERCA3; SR Ca(2+)-ATPase 3", "protein_names_refseq": "ATPase, Ca++ transporting, ubiquitous; SERCA3; SR Ca(2+)-ATPase 3; calcium pump 3; chkSERCA3; sarcoendoplasmic reticulum calcium ATPase; sarcoplasmic/endoplasmic reticulum calcium ATPase 3", "tax_id": 9031, "disease": "", "pathway": " (gga:395707); (R-GGA-418359); (R-GGA-5578775); (R-GGA-936837)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "10413590;16104848", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: Y18063.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000323.1. On Jan 18, 2005 this sequence version replaced XP_429256.1., [RefSeq]; SERCA is mainly distributed in Purkinje neurons, whereas the PMCA seems to be expressed initially in climbing fibers, shifting to soma and spiny branchlets of Purkinje cells at late embryonic stages, [RefSeq, PubMed]; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005246 calcium channel regulator activity;GO:0016887 ATP hydrolysis activity;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0016020 membrane;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport;GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress;GO:1903515 calcium ion transport from cytosol to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q9YGL9-2", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9YHT2-1", "uniprot_id": [ { "id": "SDHB_CHICK", "url": "https://www.uniprot.org/uniprot/Q9YHT2", "type": "external" } ], "mass": 32597.0, "length": 290, "protein_name": "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial", "gene_name": "SDHB", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SDHB", "gene_names_refseq": "", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; 1.1.5.-; 1.3.5.1; Ip; Iron-sulfur subunit of complex II; Malate dehydrogenase [quinone] iron-sulfur subunit", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-372987)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15805592;16371358;16935256;2043641", "class_list": "", "function": "Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:16371358). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.5.1", "type": "external" }, { "id": "1.1.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.-", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051538 3 iron, 4 sulfur cluster binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0051537 2 iron, 2 sulfur cluster binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0022904 respiratory electron transport chain;GO:0009060 aerobic respiration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q9YHT2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9YHY9-1", "uniprot_id": [ { "id": "OTC_CHICK", "url": "https://www.uniprot.org/uniprot/Q9YHY9", "type": "external" } ], "mass": 40245.0, "length": 354, "protein_name": "Ornithine transcarbamylase, mitochondrial", "gene_name": "OTC", "organism": "Chicken", "refseq_name": "ornithine transcarbamylase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_990241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990241", "type": "external" } ], "gene_names_uniprotkb": "OTC", "gene_names_refseq": "OTC", "protein_names_uniprotkb": "Ornithine transcarbamylase, mitochondrial; 2.1.3.3; OTCase; Ornithine carbamoyltransferase, mitochondrial", "protein_names_refseq": "OTCase; ornithine carbamoyltransferase, mitochondrial; ornithine transcarbamylase, mitochondrial precursor; ornithine transcarbamylase, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (gga:395735); (R-GGA-1268020); (R-GGA-187630); (R-GGA-70635)", "pathway_count": 4, "publication_count": 7, "publication_id_list": "3606562;6418730;6419722;6661175;6682551;7332529;9792920", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF065629.1, SRR13267650.4776.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992559 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000021.1. On Sep 23, 2021 this sequence version replaced NP_990241.1., [RefSeq]; Catalyzes the second step of the urea cycle, the condensation of carbamoyl phosphate with L-ornithine to form L-citrulline (PubMed:7332529). The urea cycle ensures the detoxification of ammonia by converting it to urea for excretion (Probable)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.39", "type": "external" }, { "id": "2.1.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.3.3", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" } ], "go_molecular_function": "GO:0004585 ornithine carbamoyltransferase activity;GO:0016597 amino acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0019240 citrulline biosynthetic process;GO:0000050 urea cycle;GO:0042450 L-arginine biosynthetic process via ornithine", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q9YHY9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q9YIB9-1", "uniprot_id": [ { "id": "HIF1A_CHICK", "url": "https://www.uniprot.org/uniprot/Q9YIB9", "type": "external" } ], "mass": 90542.0, "length": 811, "protein_name": "Hypoxia-inducible factor 1-alpha", "gene_name": "HIF1A", "organism": "Chicken", "refseq_name": "hypoxia-inducible factor 1-alpha isoform 1", "refseq_ac": [ { "id": "NP_989628", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989628", "type": "external" } ], "gene_names_uniprotkb": "HIF1A", "gene_names_refseq": "HIF1A", "protein_names_uniprotkb": "Hypoxia-inducible factor 1-alpha; HIF-1-alpha; HIF1-alpha", "protein_names_refseq": "HIF-1-alpha; HIF1-alpha; hypoxia inducible factor 1 subunit alpha; hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor); hypoxia-inducible factor 1-alpha isoform 1; hypoxia-inducible factor 1-alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:374177)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "17284428;17954589;18467628;19777592;28693310;29504370;31393948;33764895", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AB013746.3, SRR13267655.75290.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000215.1. On Oct 6, 2021 this sequence version replaced NP_989628.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data suggest that developing coronary vessels may be subject to a level of regulation that is dependent on differential oxygen levels within cardiac tissues and subsequent HIF-1alpha regulation of gene expression., [RefSeq, PubMed]; FK228 (HIF-1alpha inhibitor) significantly (P less than 0.05) down- regulated the mRNA and protein levels of HIF-1alpha and Hsp90, restored the size of growth plate and diminished lameness. In conclusion, HIF-1alpha and Hsp90 play an important role in the formation of avascular growth plate and there is a direct relationship between HIF-1alpha and Hsp90 for the progression of TD pathogenesis, [RefSeq, PubMed]; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease., [UniProtKB, UniProtKB]; HIF-1alpha, -2alpha, and -3alpha expressions in the tibial growth plate of Tibetan chickens were upregulated by hypoxia and the change was more significant than in Arbor Acres chickens., [RefSeq, PubMed]; Hypoxia signaling through HIF-1 and VEGF provides an autocrine survival signal in the developing cardiac output flow tract[OFT] and that perturbation in this pathway causes OFT defects that model congenital human conotruncal heart defects., [RefSeq, PubMed]; Results showed that HIF-1alpha mRNA displayed tissue specific differential expression, with the highest in the brain, [RefSeq, PubMed]; Role of cardiac hypoxia in the pathogenesis of sudden death syndrome in broiler chickens - A metabolic and molecular study. Publication Status: Online-Only, [RefSeq, PubMed]; Study aimed at investigating absolute expression of hypoxia-inducible factor-1 alpha subunit (HIF1A) and genes involved in stress responses and muscle repair. Findings support hypoxia within the abnormal breasts, with white striping and wooden breast myopathies, potentially associated with oversized muscle fibers. Publication Status: Online-Only, [RefSeq, PubMed]; This study found that tissue hypoxia is likely a normal component of embryonic development in the chicken based on the upregulation of hypoxia response genes., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001223 transcription coactivator binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001666 response to hypoxia;GO:0071456 cellular response to hypoxia;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q9YIB9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "R4GH67-1", "uniprot_id": [ { "id": "R4GH67_CHICK", "url": "https://www.uniprot.org/uniprot/R4GH67", "type": "external" } ], "mass": 71060.0, "length": 661, "protein_name": "Eomesodermin", "gene_name": "EOMES", "organism": "Chicken", "refseq_name": "eomesodermin homolog", "refseq_ac": [ { "id": "NP_001308484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308484", "type": "external" } ], "gene_names_uniprotkb": "EOMES", "gene_names_refseq": "EOMES", "protein_names_uniprotkb": "Eomesodermin", "protein_names_refseq": "eomesodermin homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:428443)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "20014105;25789773", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000037.1. On Mar 26, 2016 this sequence version replaced XP_004939476.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Expressed in extraembryonic tissues, but temporal pattern of expression differs from what occurs in mouse, [RefSeq, PubMed]; This suggests that the 20 Kb duplication contains regulatory elements affecting EOMES expression. These findings complete our characterization of the genetic basis of the three major comb loci in the chicken Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031490 chromatin DNA binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0001714 endodermal cell fate specification;GO:0002302 CD8-positive, alpha-beta T cell differentiation involved in immune response;GO:0060809 mesodermal to mesenchymal transition involved in gastrulation;GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "R4GH67-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "R4GHZ8-1", "uniprot_id": [ { "id": "R4GHZ8_CHICK", "url": "https://www.uniprot.org/uniprot/R4GHZ8", "type": "external" } ], "mass": 42389.0, "length": 379, "protein_name": "Sphingosine 1-phosphate receptor 1", "gene_name": "S1PR1", "organism": "Chicken", "refseq_name": "sphingosine 1-phosphate receptor 1", "refseq_ac": [ { "id": "XP_040533611", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040533611", "type": "external" } ], "gene_names_uniprotkb": "S1PR1", "gene_names_refseq": "S1PR1", "protein_names_uniprotkb": "Sphingosine 1-phosphate receptor 1; Sphingosine 1-phosphate receptor Edg-1", "protein_names_refseq": "sphingosine 1-phosphate receptor 1", "tax_id": 9031, "disease": "", "pathway": " (gga:424462); (R-GGA-419408)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052580.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0038036 sphingosine-1-phosphate receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0098793 presynapse", "go_biological_process": "GO:0045124 regulation of bone resorption;GO:0003376 sphingosine-1-phosphate receptor signaling pathway;GO:0001525 angiogenesis;GO:0006935 chemotaxis;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "R4GHZ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "R4GJD4-1", "uniprot_id": [ { "id": "R4GJD4_CHICK", "url": "https://www.uniprot.org/uniprot/R4GJD4", "type": "external" } ], "mass": 47592.0, "length": 421, "protein_name": "Potassium inwardly rectifying channel subfamily J member 8", "gene_name": "KCNJ8", "organism": "Chicken", "refseq_name": "ATP-sensitive inward rectifier potassium channel 8", "refseq_ac": [ { "id": "NP_001280216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280216", "type": "external" } ], "gene_names_uniprotkb": "KCNJ8", "gene_names_refseq": "KCNJ8; Kir6.1", "protein_names_uniprotkb": "Potassium inwardly rectifying channel subfamily J member 8", "protein_names_refseq": "ATP-sensitive inward rectifier potassium channel 8; ATP-sensitive potassium channel Kir6.1", "tax_id": 9031, "disease": "", "pathway": " (gga:395973); (R-GGA-1296025)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267658.22783.1, HAEK01051909.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Sep 23, 2021 this sequence version replaced NP_001280216.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PZF6", "ec_number_list": [], "go_molecular_function": "GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization;GO:0015272 ATP-activated inward rectifier potassium channel activity;GO:0099508 voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030016 myofibril;GO:0098793 presynapse;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "R4GJD4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "R4GJE0-1", "uniprot_id": [ { "id": "R4GJE0_CHICK", "url": "https://www.uniprot.org/uniprot/R4GJE0", "type": "external" } ], "mass": 26884.0, "length": 257, "protein_name": "Hes family bHLH transcription factor 1", "gene_name": "HES1", "organism": "Chicken", "refseq_name": "transcription factor HES-1", "refseq_ac": [ { "id": "XP_015147078", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015147078", "type": "external" } ], "gene_names_uniprotkb": "HES1", "gene_names_refseq": "HES1", "protein_names_uniprotkb": "Hes family bHLH transcription factor 1", "protein_names_refseq": "transcription factor HES-1", "tax_id": 9031, "disease": "", "pathway": " (gga:769039)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052540.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XP_015147078.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:2000981 negative regulation of inner ear receptor cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0045665 negative regulation of neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "R4GJE0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "R4GK80-1", "uniprot_id": [ { "id": "R4GK80_CHICK", "url": "https://www.uniprot.org/uniprot/R4GK80", "type": "external" } ], "mass": 6091.0, "length": 52, "protein_name": "Phospholamban", "gene_name": "PLN", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PLN", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholamban; PLB", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396378); (R-GGA-5578775); (R-GGA-936837)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0044325 transmembrane transporter binding;GO:0042030 ATPase inhibitor activity;GO:0141110 transporter inhibitor activity", "go_cellular_component": "GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0016529 sarcoplasmic reticulum;GO:0033017 sarcoplasmic reticulum membrane;GO:0090534 calcium ion-transporting ATPase complex", "go_biological_process": "GO:0008542 visual learning;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0010459 negative regulation of heart rate;GO:0001675 acrosome assembly;GO:0045475 locomotor rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "R4GK80-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "R4GLC9-1", "uniprot_id": [ { "id": "R4GLC9_CHICK", "url": "https://www.uniprot.org/uniprot/R4GLC9", "type": "external" } ], "mass": 19643.0, "length": 179, "protein_name": "Transcription factor 21", "gene_name": "TCF21", "organism": "Chicken", "refseq_name": "transcription factor 21", "refseq_ac": [ { "id": "NP_001264640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264640", "type": "external" } ], "gene_names_uniprotkb": "TCF21", "gene_names_refseq": "TCF21", "protein_names_uniprotkb": "Transcription factor 21", "protein_names_refseq": "transcription factor 21", "tax_id": 9031, "disease": "", "pathway": " (gga:421697)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "22687751;34872001", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX932800.2, BU459258.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992440, SAMN06140852 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000063.1. On Apr 14, 2013 this sequence version replaced XP_419734.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Data show that all-trans-retinoic acid (RA) inhibition leads to decreased Pod1/Tcf21 expression in intact heart., [RefSeq, PubMed]; Genome-wide survey and functional analysis reveal TCF21 promotes chicken preadipocyte differentiation by directly upregulating HTR2A., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0070888 E-box binding;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0007530 sex determination;GO:0060435 bronchiole development;GO:0072162 metanephric mesenchymal cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "R4GLC9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "R9PXL7-1", "uniprot_id": [ { "id": "R9PXL7_CHICK", "url": "https://www.uniprot.org/uniprot/R9PXL7", "type": "external" } ], "mass": 56408.0, "length": 481, "protein_name": "Phosphatidylserine synthase", "gene_name": "PTDSS2", "organism": "Chicken", "refseq_name": "phosphatidylserine synthase 2", "refseq_ac": [ { "id": "NP_001186432", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186432", "type": "external" } ], "gene_names_uniprotkb": "PTDSS2", "gene_names_refseq": "PSS-2; PTDSS2", "protein_names_uniprotkb": "Phosphatidylserine synthase; 2.7.8.29; Serine-exchange enzyme", "protein_names_refseq": "phosphatidylserine synthase 2; ptdSer synthase 2; serine-exchange enzyme II", "tax_id": 9031, "disease": "", "pathway": " (gga:422997); (R-GGA-1483101)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.255863.1, SRR13267656.28128.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000212.1. On Sep 23, 2021 this sequence version replaced NP_001186432.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.8.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.29", "type": "external" } ], "go_molecular_function": "GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity;GO:0106245 L-serine-phosphatidylethanolamine phosphatidyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006659 phosphatidylserine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "R9PXL7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A0A0MQ60-1", "uniprot_id": [ { "id": "A0A0A0MQ60_CHICK", "url": "https://www.uniprot.org/uniprot/A0A0A0MQ60", "type": "external" } ], "mass": 40608.0, "length": 361, "protein_name": "Melatonin receptor 1B", "gene_name": "MTNR1B", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MTNR1B", "gene_names_refseq": "", "protein_names_uniprotkb": "Melatonin receptor 1B", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:396338); (R-GGA-373076); (R-GGA-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "High affinity receptor for melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibits adenylate cyclase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008502 melatonin receptor activity;GO:1904408 melatonin binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0042593 glucose homeostasis;GO:0050796 regulation of insulin secretion;GO:0045820 negative regulation of glycolytic process;GO:0046325 negative regulation of D-glucose import", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A0A0MQ60-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140T8F7-1", "uniprot_id": [ { "id": "A0A140T8F7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A140T8F7", "type": "external" } ], "mass": 26683.0, "length": 239, "protein_name": "Nerve growth factor", "gene_name": "NGF", "organism": "Chicken", "refseq_name": "beta-nerve growth factor precursor", "refseq_ac": [ { "id": "NP_001280037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280037", "type": "external" } ], "gene_names_uniprotkb": "NGF", "gene_names_refseq": "NGFB; NGF; beta-NGF", "protein_names_uniprotkb": "Nerve growth factor", "protein_names_refseq": "beta-nerve growth factor precursor; beta-nerve growth factor; nerve growth factor (beta polypeptide)", "tax_id": 9031, "disease": "", "pathway": " (gga:396466); (R-GGA-1257604); (R-GGA-167060); (R-GGA-170968); (R-GGA-170984); (R-GGA-177504); (R-GGA-187042); (R-GGA-198203); (R-GGA-205017); (R-GGA-205043); (R-GGA-209543); (R-GGA-209560); (R-GGA-209563)", "pathway_count": 13, "publication_count": 4, "publication_id_list": "20018664;22308471;23223289;25846486", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CD217960.1, ERR2286007.72029.1 [ECO:0000332] RNAseq introns :: partial sample support SAMEA103992528, SAMEA103992531 [ECO:0000350] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD217960.1, BU337330.1 and BU313448.1. On May 30, 2014 this sequence version replaced XP_003642777.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Data show that endogenous NGF induces DNA replication in a subpopulation of differentiating retinal ganglion cells that express both the neurotrophin receptor p75 and the E2F1 transcription factor, but that lack the retinoblastoma protein., [RefSeq, PubMed]; NGF promotes sensory axon branching through regulation of the actin cytoskeleton using both canonical signaling mechanisms and intra-axonal protein synthesis downstream of PI3K signaling., [RefSeq, PubMed]; Results suggest that NGF differentially affects the phosphorylation of MAP1B within the main axon shaft and the laterally projecting filopodia, [RefSeq, PubMed]; These results reveal a role for NGF in early chicken embryo development., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0005163 nerve growth factor receptor binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010628 positive regulation of gene expression;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A140T8F7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140T8G0-1", "uniprot_id": [ { "id": "A0A140T8G0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A140T8G0", "type": "external" } ], "mass": 14212.0, "length": 126, "protein_name": "Liver basic fatty acid binding protein", "gene_name": "LBFABP", "organism": "Chicken", "refseq_name": "fatty acid-binding protein, liver", "refseq_ac": [ { "id": "NP_989965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989965", "type": "external" } ], "gene_names_uniprotkb": "LBFABP", "gene_names_refseq": "FABP10; L-BABP; LB-FABP; LBFABP", "protein_names_uniprotkb": "Liver basic fatty acid binding protein", "protein_names_refseq": "fatty acid-binding protein, liver; liver basic FABP; liver bile acid-binding protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395345)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19540927;24114214", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AF380998.1, BG712303.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN08016666 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000339.1., [RefSeq]; A high expression level of L-FABP and L-BABP leads to a high lipogenesis rate and, ultimately, to lipid deposition. Publication Status: Online-Only, [RefSeq, PubMed]; Investigation of the gene expression levels of L-FABP and Lb-FABP in relation to the pre-and post-hatching development, diurnal cycle and feeding state in the liver, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A140T8G0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140T8H9-1", "uniprot_id": [ { "id": "A0A140T8H9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A140T8H9", "type": "external" } ], "mass": 55154.0, "length": 469, "protein_name": "Kinetochore protein NUF2", "gene_name": "NUF2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NUF2", "gene_names_refseq": "", "protein_names_uniprotkb": "Kinetochore protein NUF2; Cell division cycle-associated protein 1; Kinetochore protein Nuf2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395135); (R-GGA-141430); (R-GGA-141444); (R-GGA-2467813); (R-GGA-2500257); (R-GGA-5663220); (R-GGA-9648025)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051383 kinetochore organization;GO:0051301 cell division;GO:0045132 meiotic chromosome segregation;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A140T8H9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A140T8I0-1", "uniprot_id": [ { "id": "A0A140T8I0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A140T8I0", "type": "external" } ], "mass": 14411.0, "length": 131, "protein_name": "Leptin receptor overlapping transcript-like 1", "gene_name": "LEPROTL1", "organism": "Chicken", "refseq_name": "leptin receptor overlapping transcript-like 1", "refseq_ac": [ { "id": "XP_420582", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_420582", "type": "external" } ], "gene_names_uniprotkb": "LEPROTL1", "gene_names_refseq": "LEPROTL1", "protein_names_uniprotkb": "Leptin receptor overlapping transcript-like 1", "protein_names_refseq": "leptin receptor overlapping transcript-like 1", "tax_id": 9031, "disease": "", "pathway": " (gga:422625)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane", "go_biological_process": "GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A140T8I0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NT61-1", "uniprot_id": [ { "id": "A0A1D5NT61_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NT61", "type": "external" } ], "mass": 60861.0, "length": 553, "protein_name": "Glutamate dehydrogenase 1, mitochondrial", "gene_name": "GLUD2", "organism": "Chicken", "refseq_name": "glutamate dehydrogenase 1, mitochondrial", "refseq_ac": [ { "id": "NP_001383395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383395", "type": "external" } ], "gene_names_uniprotkb": "GLUD2", "gene_names_refseq": "GDH 1; GLUD1; GLUD2", "protein_names_uniprotkb": "Glutamate dehydrogenase 1, mitochondrial; 1.4.1.3", "protein_names_refseq": "GLUD2 glutamate; dehydrogenase 2; glutamate dehydrogenase 1, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (gga:423612); (R-GGA-2151201); (R-GGA-8964539); (R-GGA-9837999)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "23673664;23856561", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CR387697.1, MF415491.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992559 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000227.1 and CR387697.1. On or before Oct 17, 2021 this sequence version replaced XP_015143519.1, XP_040530884.1., [RefSeq]; Analysis of the regulation and expression of chicken glutamate dehydrogenase reveals that it may regulate post-translational modifications of histone H3 by removing the N-terminal residues of the histone, [RefSeq, PubMed]; H3ase activity was only specific to chicken liver as it was not demonstrated in other tissues like heart, muscle and brain of chicken. We assign a novel serine like protease activity to GDH which is specific to histone H3., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "6.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.1", "type": "external" }, { "id": "6.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.17", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" } ], "go_molecular_function": "GO:0004352 glutamate dehydrogenase (NAD+) activity;GO:0004353 glutamate dehydrogenase [NAD(P)+] activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006541 glutamine metabolic process;GO:0006538 L-glutamate catabolic process;GO:0072350 tricarboxylic acid metabolic process;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1D5NT61-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NTS2-1", "uniprot_id": [ { "id": "A0A1D5NTS2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NTS2", "type": "external" } ], "mass": 29723.0, "length": 262, "protein_name": "Carbonic anhydrase", "gene_name": "CA3A", "organism": "Chicken", "refseq_name": "carbonic anhydrase 3A", "refseq_ac": [ { "id": "NP_001264340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264340", "type": "external" } ], "gene_names_uniprotkb": "CA3A", "gene_names_refseq": "CA3A; CA3", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1", "protein_names_refseq": "carbonic anhydrase 3A; carbonic anhydrase III, muscle specific", "tax_id": 9031, "disease": "", "pathway": " (gga:420208)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU437187.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000044.1. On Apr 6, 2013 this sequence version replaced XP_418319.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NTS2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NTV7-1", "uniprot_id": [ { "id": "A0A1D5NTV7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NTV7", "type": "external" } ], "mass": 49873.0, "length": 438, "protein_name": "Zinc finger and BTB domain containing 26", "gene_name": "ZBTB26", "organism": "Chicken", "refseq_name": "zinc finger and BTB domain-containing protein 26", "refseq_ac": [ { "id": "NP_001264568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264568", "type": "external" } ], "gene_names_uniprotkb": "ZBTB26", "gene_names_refseq": "ZBTB26", "protein_names_uniprotkb": "Zinc finger and BTB domain containing 26", "protein_names_refseq": "zinc finger and BTB domain-containing protein 26", "tax_id": 9031, "disease": "", "pathway": " (gga:417107)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267656.9375.1, SRR13267661.10171.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000308.1. On Apr 13, 2013 this sequence version replaced XP_003642347.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same breed was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NTV7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NTX3-1", "uniprot_id": [ { "id": "A0A1D5NTX3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NTX3", "type": "external" } ], "mass": 23329.0, "length": 208, "protein_name": "ADP-ribosylation factor-like 8B-like", "gene_name": "ARL8BL", "organism": "Chicken", "refseq_name": "ADP-ribosylation factor-like 8B-like isoform X1", "refseq_ac": [ { "id": "XP_015137488", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015137488", "type": "external" } ], "gene_names_uniprotkb": "ARL8BL", "gene_names_refseq": "ARL8BL", "protein_names_uniprotkb": "ADP-ribosylation factor-like 8B-like", "protein_names_refseq": "ADP-ribosylation factor-like 8B-like isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0051301 cell division;GO:0008089 anterograde axonal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NTX3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NUC6-1", "uniprot_id": [ { "id": "A0A1D5NUC6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NUC6", "type": "external" } ], "mass": 20414.0, "length": 179, "protein_name": "Mediator of RNA polymerase II transcription subunit 30", "gene_name": "MED30", "organism": "Chicken", "refseq_name": "mediator of RNA polymerase II transcription subunit 30", "refseq_ac": [ { "id": "NP_001264365", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264365", "type": "external" } ], "gene_names_uniprotkb": "MED30", "gene_names_refseq": "MED30; THRAP6", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 30; Mediator complex subunit 30", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 30; thyroid hormone receptor associated protein 6", "tax_id": 9031, "disease": "", "pathway": " (gga:420284); (R-GGA-9841922)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX932068.1, HAEK01132315.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000044.1. On or before Apr 7, 2013 this sequence version replaced XP_418397.1, XP_001232202.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046966 nuclear thyroid hormone receptor binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016592 mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NUC6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NUM5-1", "uniprot_id": [ { "id": "A0A1D5NUM5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NUM5", "type": "external" } ], "mass": 47065.0, "length": 418, "protein_name": "AP-3 complex subunit mu-2", "gene_name": "AP3M2", "organism": "Chicken", "refseq_name": "AP-3 complex subunit mu-2 isoform X2", "refseq_ac": [ { "id": "XP_424403", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_424403", "type": "external" } ], "gene_names_uniprotkb": "AP3M2", "gene_names_refseq": "AP3M2", "protein_names_uniprotkb": "AP-3 complex subunit mu-2", "protein_names_refseq": "AP-3 complex subunit mu-2 isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052553.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_424403.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035615 clathrin adaptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005802 trans-Golgi network;GO:1904115 axon cytoplasm;GO:0030121 AP-1 adaptor complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006897 endocytosis;GO:0048490 anterograde synaptic vesicle transport;GO:0048488 synaptic vesicle endocytosis;GO:0006896 Golgi to vacuole transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NUM5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NUQ3-1", "uniprot_id": [ { "id": "A0A1D5NUQ3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NUQ3", "type": "external" } ], "mass": 31121.0, "length": 273, "protein_name": "SplA/ryanodine receptor domain and SOCS box containing 4", "gene_name": "SPSB4", "organism": "Chicken", "refseq_name": "SPRY domain-containing SOCS box protein 4 isoform X1", "refseq_ac": [ { "id": "XP_025009389", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_025009389", "type": "external" } ], "gene_names_uniprotkb": "SPSB4", "gene_names_refseq": "SPSB4", "protein_names_uniprotkb": "SplA/ryanodine receptor domain and SOCS box containing 4", "protein_names_refseq": "SPRY domain-containing SOCS box protein 4 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:429129); (R-GGA-8951664); (R-GGA-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052540.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0042752 regulation of circadian rhythm;GO:1902916 positive regulation of protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NUQ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NUT5-1", "uniprot_id": [ { "id": "A0A1D5NUT5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NUT5", "type": "external" } ], "mass": 41511.0, "length": 379, "protein_name": "Nuclear receptor subfamily 2 group F member 6", "gene_name": "NR2F6", "organism": "Chicken", "refseq_name": "nuclear receptor subfamily 2 group F member 6 isoform X2", "refseq_ac": [ { "id": "XP_015155582", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015155582", "type": "external" } ], "gene_names_uniprotkb": "NR2F6", "gene_names_refseq": "NR2F6", "protein_names_uniprotkb": "Nuclear receptor subfamily 2 group F member 6; V-erbA-related protein 2", "protein_names_refseq": "nuclear receptor subfamily 2 group F member 6 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:100859014); (R-GGA-383280)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052559.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XP_015155582.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0016607 nuclear speck", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NUT5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NVI1-1", "uniprot_id": [ { "id": "A0A1D5NVI1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NVI1", "type": "external" } ], "mass": 21835.0, "length": 192, "protein_name": "Large ribosomal subunit protein uL6", "gene_name": "RPL9", "organism": "Chicken", "refseq_name": "large ribosomal subunit protein uL6", "refseq_ac": [ { "id": "NP_001244262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001244262", "type": "external" } ], "gene_names_uniprotkb": "RPL9", "gene_names_refseq": "RPL9", "protein_names_uniprotkb": "Large ribosomal subunit protein uL6; 60S ribosomal protein L9", "protein_names_refseq": "large ribosomal subunit protein uL6", "tax_id": 9031, "disease": "", "pathway": " (gga:425468); (R-GGA-1799339); (R-GGA-72706); (R-GGA-975956); (R-GGA-975957); (R-GGA-9954709); (R-GGA-9954714); (R-GGA-9954716)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "16879355;38395592", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CF251699.1, BU144270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Mar 31, 2012 this sequence version replaced XP_003641294.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1D5NVI1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NVI6-1", "uniprot_id": [ { "id": "A0A1D5NVI6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NVI6", "type": "external" } ], "mass": 88435.0, "length": 766, "protein_name": "BMP/retinoic acid inducible neural specific 3", "gene_name": "BRINP3", "organism": "Chicken", "refseq_name": "BMP/retinoic acid-inducible neural-specific protein 3 isoform X1", "refseq_ac": [ { "id": "XP_004943345", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004943345", "type": "external" } ], "gene_names_uniprotkb": "BRINP3", "gene_names_refseq": "BRINP3", "protein_names_uniprotkb": "BMP/retinoic acid inducible neural specific 3", "protein_names_refseq": "BMP/retinoic acid-inducible neural-specific protein 3 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:429077)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052539.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0045666 positive regulation of neuron differentiation;GO:0071300 cellular response to retinoic acid;GO:0045930 negative regulation of mitotic cell cycle;GO:0021953 central nervous system neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NVI6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NVK9-1", "uniprot_id": [ { "id": "A0A1D5NVK9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NVK9", "type": "external" } ], "mass": 40775.0, "length": 350, "protein_name": "Neutrophil cytosol factor 4", "gene_name": "NCF4", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NCF4", "gene_names_refseq": "", "protein_names_uniprotkb": "Neutrophil cytosol factor 4; Neutrophil NADPH oxidase factor 4; p40-phox", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1222556); (R-GGA-1236973); (R-GGA-3299685); (R-GGA-4420097); (R-GGA-5668599); (R-GGA-9013149); (R-GGA-9013404); (R-GGA-9013423)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0016176 superoxide-generating NADPH oxidase activator activity", "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010008 endosome membrane", "go_biological_process": "GO:0006909 phagocytosis;GO:0045730 respiratory burst;GO:0042554 superoxide anion generation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NVK9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NVT2-1", "uniprot_id": [ { "id": "A0A1D5NVT2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NVT2", "type": "external" } ], "mass": 47987.0, "length": 427, "protein_name": "Sulfotransferase", "gene_name": "CHST2", "organism": "Chicken", "refseq_name": "carbohydrate sulfotransferase 2", "refseq_ac": [ { "id": "XP_040535583", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040535583", "type": "external" } ], "gene_names_uniprotkb": "CHST2", "gene_names_refseq": "CHST2", "protein_names_uniprotkb": "Sulfotransferase; 2.8.2.-", "protein_names_refseq": "carbohydrate sulfotransferase 2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2022854)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 2% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052581.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Mar 1, 2022 this sequence version replaced XP_040535583.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006954 inflammatory response;GO:0005975 carbohydrate metabolic process;GO:0006790 sulfur compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NVT2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NW01-1", "uniprot_id": [ { "id": "A0A1D5NW01_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NW01", "type": "external" } ], "mass": 145491.0, "length": 1272, "protein_name": "[histone H3]-dimethyl-L-lysine(36) demethylase", "gene_name": "KDM2A", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KDM2A", "gene_names_refseq": "", "protein_names_uniprotkb": "[histone H3]-dimethyl-L-lysine(36) demethylase; 1.14.11.27", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:425999)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.27", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.79", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0032452 histone demethylase activity;GO:0045322 unmethylated CpG binding;GO:0140680 histone H3K36me/H3K36me2 demethylase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0042752 regulation of circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NW01-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NW22-1", "uniprot_id": [ { "id": "A0A1D5NW22_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NW22", "type": "external" } ], "mass": 59812.0, "length": 521, "protein_name": "TNFAIP3-interacting protein 2", "gene_name": "TNIP2", "organism": "Chicken", "refseq_name": "TNFAIP3-interacting protein 2", "refseq_ac": [ { "id": "NP_001026337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026337", "type": "external" } ], "gene_names_uniprotkb": "TNIP2", "gene_names_refseq": "TNIP2", "protein_names_uniprotkb": "TNFAIP3-interacting protein 2; A20-binding inhibitor of NF-kappa-B activation 2", "protein_names_refseq": "TNFAIP3-interacting protein 2", "tax_id": 9031, "disease": "", "pathway": " (gga:422884); (R-GGA-5684264); (R-GGA-5689896)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851742.1, SRR13267659.213969.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000074.1. On Mar 12, 2015 this sequence version replaced NP_001026337.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:0070498 interleukin-1-mediated signaling pathway;GO:0023035 CD40 signaling pathway;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NW22-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NW93-1", "uniprot_id": [ { "id": "A0A1D5NW93_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NW93", "type": "external" } ], "mass": 16817.0, "length": 161, "protein_name": "ATP synthase F(1) complex subunit delta, mitochondrial", "gene_name": "ATP5D", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ATP5D", "gene_names_refseq": "", "protein_names_uniprotkb": "ATP synthase F(1) complex subunit delta, mitochondrial; ATP synthase F1 subunit delta; F-ATPase delta subunit", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-163210); (R-GGA-8949613)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Subunit delta, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. With the central stalk subunit gamma, is essential for the biogenesis of F(1) catalytic part of the ATP synthase complex namely in the formation of F1 assembly intermediate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0033615 mitochondrial proton-transporting ATP synthase complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NW93-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NWN1-1", "uniprot_id": [ { "id": "A0A1D5NWN1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NWN1", "type": "external" } ], "mass": 41983.0, "length": 380, "protein_name": "E3 ubiquitin-protein ligase KCMF1", "gene_name": "LOC431003", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase KCMF1 isoform X1", "refseq_ac": [ { "id": "XP_025000351", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_025000351", "type": "external" } ], "gene_names_uniprotkb": "LOC431003", "gene_names_refseq": "LOC431003", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase KCMF1; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase KCMF1 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052571.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5P0W9", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:0099536 synaptic signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NWN1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NWN8-1", "uniprot_id": [ { "id": "A0A1D5NWN8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NWN8", "type": "external" } ], "mass": 51968.0, "length": 465, "protein_name": "GDNF family receptor alpha-2", "gene_name": "GFRA2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GFRA2", "gene_names_refseq": "", "protein_names_uniprotkb": "GDNF family receptor alpha-2; GDNF receptor alpha-2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5673001); (R-GGA-8853659)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons. NRTN-binding leads to autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity;GO:1904399 heparan sulfate binding;GO:0016167 glial cell-derived neurotrophic factor receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NWN8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NWR5-1", "uniprot_id": [ { "id": "A0A1D5NWR5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NWR5", "type": "external" } ], "mass": 40675.0, "length": 370, "protein_name": "Protein FAM110B", "gene_name": "FAM110B", "organism": "Chicken", "refseq_name": "protein FAM110B isoform X1", "refseq_ac": [ { "id": "XP_004939923", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004939923", "type": "external" } ], "gene_names_uniprotkb": "FAM110B", "gene_names_refseq": "FAM110B", "protein_names_uniprotkb": "Protein FAM110B", "protein_names_refseq": "protein FAM110B isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:421134)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NWR5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NWT9-1", "uniprot_id": [ { "id": "A0A1D5NWT9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NWT9", "type": "external" } ], "mass": 13716.0, "length": 123, "protein_name": "Piercer of microtubule wall 1", "gene_name": "C9orf116", "organism": "Chicken", "refseq_name": "UPF0691 protein C9orf116 homolog isoform X1", "refseq_ac": [ { "id": "XP_024997291", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024997291", "type": "external" } ], "gene_names_uniprotkb": "C9orf116", "gene_names_refseq": "C9orf116", "protein_names_uniprotkb": "Piercer of microtubule wall 1", "protein_names_refseq": "UPF0691 protein C9orf116 homolog isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:772106)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 100% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052548.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0036126 sperm flagellum;GO:0160111 axonemal A tubule inner sheath", "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0035082 axoneme assembly;GO:0061966 establishment of left/right asymmetry", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NWT9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NWX3-1", "uniprot_id": [ { "id": "A0A1D5NWX3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NWX3", "type": "external" } ], "mass": 34472.0, "length": 299, "protein_name": "Geranylgeranyl pyrophosphate synthase", "gene_name": "GGPS1", "organism": "Chicken", "refseq_name": "geranylgeranyl pyrophosphate synthase isoform X1", "refseq_ac": [ { "id": "XP_424685", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_424685", "type": "external" } ], "gene_names_uniprotkb": "GGPS1", "gene_names_refseq": "GGPS1", "protein_names_uniprotkb": "Geranylgeranyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; 2.5.1.10; 2.5.1.1; 2.5.1.29; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranylgeranyl diphosphate synthase; Geranyltranstransferase", "protein_names_refseq": "geranylgeranyl pyrophosphate synthase isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:427092); (R-GGA-9969896)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_424685.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5NTV1", "ec_number_list": [ { "id": "2.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.1", "type": "external" }, { "id": "2.5.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.10", "type": "external" }, { "id": "2.5.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.29", "type": "external" } ], "go_molecular_function": "GO:0004161 dimethylallyltranstransferase activity;GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0004311 geranylgeranyl diphosphate synthase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0030018 Z disc", "go_biological_process": "GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NWX3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NX31-1", "uniprot_id": [ { "id": "A0A1D5NX31_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NX31", "type": "external" } ], "mass": 29154.0, "length": 258, "protein_name": "Carbonic anhydrase", "gene_name": "CA13", "organism": "Chicken", "refseq_name": "carbonic anhydrase 13", "refseq_ac": [ { "id": "XP_003640859", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003640859", "type": "external" } ], "gene_names_uniprotkb": "CA13", "gene_names_refseq": "CA13", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1", "protein_names_refseq": "carbonic anhydrase 13", "tax_id": 9031, "disease": "", "pathway": " (gga:100858989); (R-GGA-1475029)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NX31-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NX62-1", "uniprot_id": [ { "id": "A0A1D5NX62_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NX62", "type": "external" } ], "mass": 47239.0, "length": 438, "protein_name": "Forkhead box A2", "gene_name": "FOXA2", "organism": "Chicken", "refseq_name": "hepatocyte nuclear factor 3-beta", "refseq_ac": [ { "id": "NP_990101", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990101", "type": "external" } ], "gene_names_uniprotkb": "FOXA2", "gene_names_refseq": "FOXA2; HNF-3BETA", "protein_names_uniprotkb": "Forkhead box A2", "protein_names_refseq": "hepatocyte nuclear factor 3-beta; hepatocyte nuclear factor-3beta; transcription factor Foxa2", "tax_id": 9031, "disease": "", "pathway": " (gga:395539)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "20849957;22750257;24401371", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.162574.1, AF150749.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992527 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000060.1. On Oct 1, 2021 this sequence version replaced NP_990101.1., [RefSeq]; Data suggest that Nato3 is a direct target of Foxa2, a transcription activator and effector of Sonic hedgehog, the hallmark regulator of neural tube floor plate induction and spinal cord development., [RefSeq, PubMed]; Nato3 induces ectopic Foxa2-positive cells and indirectly downregulates Nkx2.2 expression., [RefSeq, PubMed]; The transcription factor FOXA2 can execute the full midbrain and spinal cord floor plate program via HH-independent and dependent mechanisms., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019904 protein domain specific binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0031018 endocrine pancreas development;GO:0030193 regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0A1D5NX62-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NX83-1", "uniprot_id": [ { "id": "A0A1D5NX83_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NX83", "type": "external" } ], "mass": 55843.0, "length": 492, "protein_name": "PHD finger protein 10", "gene_name": "PHF10", "organism": "Chicken", "refseq_name": "PHD finger protein 10 isoform X1", "refseq_ac": [ { "id": "XP_015139860", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015139860", "type": "external" } ], "gene_names_uniprotkb": "PHF10", "gene_names_refseq": "PHF10", "protein_names_uniprotkb": "PHD finger protein 10", "protein_names_refseq": "PHD finger protein 10 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:100857350); (R-GGA-9933939); (R-GGA-9933946); (R-GGA-9934037)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0004402 histone acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0071564 npBAF complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NX83-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NX87-1", "uniprot_id": [ { "id": "A0A1D5NX87_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NX87", "type": "external" } ], "mass": 30266.0, "length": 261, "protein_name": "tRNA selenocysteine-associated protein 1", "gene_name": "C2H6orf52", "organism": "Chicken", "refseq_name": "tRNA selenocysteine 1-associated protein 1 isoform 2", "refseq_ac": [ { "id": "NP_001238944", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001238944", "type": "external" } ], "gene_names_uniprotkb": "C2H6orf52", "gene_names_refseq": "C2H6orf52; TRNAU1AP", "protein_names_uniprotkb": "tRNA selenocysteine-associated protein 1", "protein_names_refseq": "tRNA selenocysteine 1-associated protein 1 isoform 2; tRNA selenocysteine 1-associated protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:420849)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01018777.1, HAEL01003831.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000040.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NX87-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NX91-1", "uniprot_id": [ { "id": "A0A1D5NX91_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NX91", "type": "external" } ], "mass": 76514.0, "length": 741, "protein_name": "Interferon regulatory factor 2 binding protein like", "gene_name": "C5H14orf4", "organism": "Chicken", "refseq_name": "probable E3 ubiquitin-protein ligase IRF2BPL", "refseq_ac": [ { "id": "XP_015143203", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015143203", "type": "external" } ], "gene_names_uniprotkb": "C5H14orf4", "gene_names_refseq": "C5H14orf4", "protein_names_uniprotkb": "Interferon regulatory factor 2 binding protein like", "protein_names_refseq": "probable E3 ubiquitin-protein ligase IRF2BPL", "tax_id": 9031, "disease": "", "pathway": " (gga:429422)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NX91-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NXC6-1", "uniprot_id": [ { "id": "A0A1D5NXC6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NXC6", "type": "external" } ], "mass": 52230.0, "length": 476, "protein_name": "Sec61 translocon alpha 2 subunit", "gene_name": "SEC61A2", "organism": "Chicken", "refseq_name": "protein transport protein Sec61 subunit alpha", "refseq_ac": [ { "id": "NP_001308549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308549", "type": "external" } ], "gene_names_uniprotkb": "SEC61A2", "gene_names_refseq": "SEC61A2", "protein_names_uniprotkb": "Sec61 translocon alpha 2 subunit", "protein_names_refseq": "Sec61 alpha 2 subunit; protein transport protein Sec61 subunit alpha", "tax_id": 9031, "disease": "", "pathway": " (gga:426369)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01013746.1, HAEL01001500.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000011.1. On Mar 29, 2016 this sequence version replaced XP_015153366.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005048 signal sequence binding;GO:0043022 ribosome binding;GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005784 Sec61 translocon complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0031204 post-translational protein targeting to membrane, translocation;GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NXC6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NXI7-1", "uniprot_id": [ { "id": "A0A1D5NXI7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NXI7", "type": "external" } ], "mass": 70119.0, "length": 645, "protein_name": "Eyes absent homolog", "gene_name": "EYA4", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EYA4", "gene_names_refseq": "", "protein_names_uniprotkb": "Eyes absent homolog; 3.1.3.48", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5693565)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045739 positive regulation of DNA repair;GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NXI7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NXK7-1", "uniprot_id": [ { "id": "A0A1D5NXK7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NXK7", "type": "external" } ], "mass": 17259.0, "length": 155, "protein_name": "Prefoldin subunit 5", "gene_name": "PFDN5", "organism": "Chicken", "refseq_name": "prefoldin subunit 5", "refseq_ac": [ { "id": "XP_003643470", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003643470", "type": "external" } ], "gene_names_uniprotkb": "PFDN5", "gene_names_refseq": "PFDN5", "protein_names_uniprotkb": "Prefoldin subunit 5", "protein_names_refseq": "prefoldin subunit 5", "tax_id": 9031, "disease": "", "pathway": " (gga:100859376)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052565.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016272 prefoldin complex", "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0045892 negative regulation of DNA-templated transcription;GO:0006457 protein folding;GO:1905907 negative regulation of amyloid fibril formation;GO:1990114 RNA polymerase II core complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NXK7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NXQ2-1", "uniprot_id": [ { "id": "A0A1D5NXQ2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NXQ2", "type": "external" } ], "mass": 64300.0, "length": 590, "protein_name": "Protein phosphatase, Mg2+/Mn2+ dependent 1D", "gene_name": "PPM1D", "organism": "Chicken", "refseq_name": "protein phosphatase 1D", "refseq_ac": [ { "id": "XP_415890", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_415890", "type": "external" } ], "gene_names_uniprotkb": "PPM1D", "gene_names_refseq": "PPM1D", "protein_names_uniprotkb": "Protein phosphatase, Mg2+/Mn2+ dependent 1D", "protein_names_refseq": "protein phosphatase 1D", "tax_id": 9031, "disease": "", "pathway": " (gga:417644); (R-GGA-8878166)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052550.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_415890.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051019 mitogen-activated protein kinase binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol", "go_biological_process": "GO:1902531 regulation of intracellular signal transduction;GO:0045814 negative regulation of gene expression, epigenetic;GO:0006346 DNA methylation-dependent constitutive heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NXQ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NXS5-1", "uniprot_id": [ { "id": "A0A1D5NXS5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NXS5", "type": "external" } ], "mass": 76950.0, "length": 692, "protein_name": "protein-glutamine gamma-glutamyltransferase", "gene_name": "TGM3", "organism": "Chicken", "refseq_name": "protein-glutamine gamma-glutamyltransferase E isoform X1", "refseq_ac": [ { "id": "XP_417392", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_417392", "type": "external" } ], "gene_names_uniprotkb": "TGM3", "gene_names_refseq": "TGM3", "protein_names_uniprotkb": "protein-glutamine gamma-glutamyltransferase; 2.3.2.13", "protein_names_refseq": "protein-glutamine gamma-glutamyltransferase E isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:419215)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052551.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_417392.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.5.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0005509 calcium ion binding;GO:0003810 protein-glutamine gamma-glutamyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031234 extrinsic component of cytoplasmic side of plasma membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030216 keratinocyte differentiation;GO:0018149 peptide cross-linking", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NXS5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NY46-1", "uniprot_id": [ { "id": "A0A1D5NY46_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NY46", "type": "external" } ], "mass": 40415.0, "length": 363, "protein_name": "POU domain protein", "gene_name": "POU1F1", "organism": "Chicken", "refseq_name": "pituitary-specific positive transcription factor 1 isoform 1", "refseq_ac": [ { "id": "NP_001383031", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383031", "type": "external" } ], "gene_names_uniprotkb": "POU1F1", "gene_names_refseq": "GHF-1; PIT-1; PIT1; POU1F1; Pit-1*", "protein_names_uniprotkb": "POU domain protein", "protein_names_refseq": "POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1); Pit-1/GHF-1; pituitary specific transcription factor-1; pituitary specific transcription factor; pituitary-specific positive transcription factor 1 isoform 1; pituitary-specific positive transcription factor 1 variant alpha", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "14967913;15595273;18304318;22499861;22581457", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ236856.1 [ECO:0000332] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000019.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications., [RefSeq]; Analysis of differential abilities of chicken Pit1 isoforms to regulate the GH promoter, [RefSeq, PubMed]; Our study found that polymorphisms of PIT1 gene and their haplotypes were associated with chicken growth traits and not with carcass and fatty traits Publication Status: Online-Only, [RefSeq, PubMed]; Pit-1 has a role in mediating the stimulatory effects of TRH on pituitary hormones like GH., [RefSeq, PubMed]; Pit-1 protein induction occurs in 6 types of glandular cells, suggesting that Pit-1 may regulate hormone synthesis in each glandular cell in the anterior pituitary., [RefSeq, PubMed]; The Pit-1 gene is polymorphic and has a significant effect on growth traits in chickens., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0A1D5NY46-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NYF8-1", "uniprot_id": [ { "id": "A0A1D5NYF8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NYF8", "type": "external" } ], "mass": 35180.0, "length": 320, "protein_name": "Protein SEC13 homolog", "gene_name": "SEC13", "organism": "Chicken", "refseq_name": "protein SEC13 homolog", "refseq_ac": [ { "id": "NP_001264770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264770", "type": "external" } ], "gene_names_uniprotkb": "SEC13", "gene_names_refseq": "SEC13L1; SEC13", "protein_names_uniprotkb": "Protein SEC13 homolog; GATOR2 complex protein SEC13; SEC13-like protein 1", "protein_names_refseq": "SEC13-like 1; protein SEC13 homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:416119); (R-GGA-141430); (R-GGA-141444); (R-GGA-159227); (R-GGA-159230); (R-GGA-159231); (R-GGA-159236); (R-GGA-1855170); (R-GGA-1855196); (R-GGA-1855229); (R-GGA-191859); (R-GGA-204005); (R-GGA-2467813); (R-GGA-2500257); (R-GGA-3108214); (R-GGA-3232142); (R-GGA-3301854); (R-GGA-4085377); (R-GGA-4551638); (R-GGA-5663220); (R-GGA-9615933); (R-GGA-9639288); (R-GGA-9648025); (R-GGA-983170)", "pathway_count": 24, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01012439.1, HAEL01000134.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000252.1. On Apr 24, 2013 this sequence version replaced XP_414450.3., [RefSeq]; As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway. The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex. GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1. In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation. In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex. Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles. Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005643 nuclear pore;GO:0005765 lysosomal membrane;GO:0031080 nuclear pore outer ring;GO:0005654 nucleoplasm;GO:0000776 kinetochore", "go_biological_process": "GO:0015031 protein transport;GO:0051028 mRNA transport;GO:1904263 positive regulation of TORC1 signaling;GO:0090110 COPII-coated vesicle cargo loading;GO:0031669 cellular response to nutrient levels", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NYF8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NYL4-1", "uniprot_id": [ { "id": "A0A1D5NYL4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NYL4", "type": "external" } ], "mass": 62945.0, "length": 570, "protein_name": "Myocyte enhancer factor 2D", "gene_name": "MEF2D", "organism": "Chicken", "refseq_name": "myocyte-specific enhancer factor 2D isoform X2", "refseq_ac": [ { "id": "XP_040508313", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040508313", "type": "external" } ], "gene_names_uniprotkb": "MEF2D", "gene_names_refseq": "MEF2D", "protein_names_uniprotkb": "Myocyte enhancer factor 2D", "protein_names_refseq": "myocyte-specific enhancer factor 2D isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052556.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NYL4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NYU5-1", "uniprot_id": [ { "id": "A0A1D5NYU5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NYU5", "type": "external" } ], "mass": 12336.0, "length": 104, "protein_name": "SRA stem-loop interacting RNA binding protein", "gene_name": "SLIRP", "organism": "Chicken", "refseq_name": "SRA stem-loop-interacting RNA-binding protein, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_001235249", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001235249", "type": "external" } ], "gene_names_uniprotkb": "SLIRP", "gene_names_refseq": "SLIRP", "protein_names_uniprotkb": "SRA stem-loop interacting RNA binding protein", "protein_names_refseq": "SRA stem-loop-interacting RNA-binding protein, mitochondrial isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:772054)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0048471 perinuclear region of cytoplasm;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0097222 mitochondrial mRNA polyadenylation;GO:1905638 negative regulation of mitochondrial mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NYU5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NZ26-1", "uniprot_id": [ { "id": "A0A1D5NZ26_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NZ26", "type": "external" } ], "mass": 72703.0, "length": 638, "protein_name": "Grainyhead like transcription factor 1", "gene_name": "GRHL1", "organism": "Chicken", "refseq_name": "grainyhead-like protein 1 homolog isoform X1", "refseq_ac": [ { "id": "XP_015131563", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015131563", "type": "external" } ], "gene_names_uniprotkb": "GRHL1", "gene_names_refseq": "GRHL1", "protein_names_uniprotkb": "Grainyhead like transcription factor 1", "protein_names_refseq": "grainyhead-like protein 1 homolog isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:428651)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008544 epidermis development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NZ26-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NZ82-1", "uniprot_id": [ { "id": "A0A1D5NZ82_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NZ82", "type": "external" } ], "mass": 123937.0, "length": 1109, "protein_name": "ADAM metallopeptidase with thrombospondin type 1 motif, 10", "gene_name": "ADAMTS10", "organism": "Chicken", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor", "refseq_ac": [ { "id": "NP_001376576", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376576", "type": "external" } ], "gene_names_uniprotkb": "ADAMTS10", "gene_names_refseq": "ADAMTS10", "protein_names_uniprotkb": "ADAM metallopeptidase with thrombospondin type 1 motif, 10", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 10 precursor", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5173214)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000375.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NZ82-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NZ94-1", "uniprot_id": [ { "id": "A0A1D5NZ94_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NZ94", "type": "external" } ], "mass": 60314.0, "length": 543, "protein_name": "Photopigment melanopsin-like", "gene_name": "OPN4-1", "organism": "Chicken", "refseq_name": "photopigment melanopsin-like", "refseq_ac": [ { "id": "NP_001384890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001384890", "type": "external" } ], "gene_names_uniprotkb": "OPN4-1", "gene_names_refseq": "OPN4-1S; OPN4-1; OPN4x; cOPN4-1L; cOPN4-1S", "protein_names_uniprotkb": "Photopigment melanopsin-like", "protein_names_refseq": "melanopsin 1; photopigment melanopsin-like; putative photopigment melanopsin", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "16217736", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA103992482, SAMEA103992484 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000073.1. On Dec 6, 2021 this sequence version replaced XP_040554628.1., [RefSeq]; Two types of melanopsin transcripts are expressed in the developing chicken retina, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity;GO:0004930 G protein-coupled receptor activity;GO:0009881 photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071482 cellular response to light stimulus;GO:0016037 light absorption", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5NZ94-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NZE1-1", "uniprot_id": [ { "id": "A0A1D5NZE1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NZE1", "type": "external" } ], "mass": 55755.0, "length": 495, "protein_name": "Cytidine and dCMP deaminase domain-containing protein 1", "gene_name": "CDADC1", "organism": "Chicken", "refseq_name": "cytidine and dCMP deaminase domain-containing protein 1 isoform X1", "refseq_ac": [ { "id": "XP_417059", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_417059", "type": "external" } ], "gene_names_uniprotkb": "CDADC1", "gene_names_refseq": "CDADC1", "protein_names_uniprotkb": "Cytidine and dCMP deaminase domain-containing protein 1; 3.5.4.5; Cytidine deaminase", "protein_names_refseq": "cytidine and dCMP deaminase domain-containing protein 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:418864)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" } ], "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0004132 dCMP deaminase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070383 DNA cytosine deamination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NZE1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NZN5-1", "uniprot_id": [ { "id": "A0A1D5NZN5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NZN5", "type": "external" } ], "mass": 23033.0, "length": 200, "protein_name": "Ephrin A2", "gene_name": "EFNA2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EFNA2", "gene_names_refseq": "", "protein_names_uniprotkb": "Ephrin A2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2682334); (R-GGA-3928663); (R-GGA-3928665)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0048013 ephrin receptor signaling pathway;GO:0046849 bone remodeling;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NZN5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P040-1", "uniprot_id": [ { "id": "A0A1D5P040_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P040", "type": "external" } ], "mass": 25059.0, "length": 224, "protein_name": "Lysosomal-associated transmembrane protein 4B", "gene_name": "LAPTM4B", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LAPTM4B", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysosomal-associated transmembrane protein 4B", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0031625 ubiquitin protein ligase binding;GO:0019900 kinase binding;GO:0097001 ceramide binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0042995 cell projection;GO:0032585 multivesicular body membrane;GO:0005769 early endosome", "go_biological_process": "GO:0007032 endosome organization;GO:1905166 negative regulation of lysosomal protein catabolic process;GO:0032911 negative regulation of transforming growth factor beta1 production;GO:0032509 endosome transport via multivesicular body sorting pathway;GO:0097213 regulation of lysosomal membrane permeability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P040-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P042-1", "uniprot_id": [ { "id": "A0A1D5P042_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P042", "type": "external" } ], "mass": 23302.0, "length": 207, "protein_name": "Noggin", "gene_name": "NOG2", "organism": "Chicken", "refseq_name": "noggin-2 precursor", "refseq_ac": [ { "id": "NP_001034693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034693", "type": "external" } ], "gene_names_uniprotkb": "NOG2", "gene_names_refseq": "NOG2", "protein_names_uniprotkb": "Noggin", "protein_names_refseq": "noggin-2 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:427689)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: AY779058.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. On Dec 8, 2021 this sequence version replaced NP_001034693.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0001649 osteoblast differentiation;GO:0009953 dorsal/ventral pattern formation;GO:0045596 negative regulation of cell differentiation;GO:0051216 cartilage development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P042-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P092-1", "uniprot_id": [ { "id": "A0A1D5P092_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P092", "type": "external" } ], "mass": 76468.0, "length": 685, "protein_name": "ATP binding cassette subfamily G member 4", "gene_name": "ABCG4", "organism": "Chicken", "refseq_name": "ATP-binding cassette sub-family G member 4 isoform X2", "refseq_ac": [ { "id": "XP_040508098", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040508098", "type": "external" } ], "gene_names_uniprotkb": "ABCG4", "gene_names_refseq": "ABCG4", "protein_names_uniprotkb": "ATP binding cassette subfamily G member 4", "protein_names_refseq": "ATP-binding cassette sub-family G member 4 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:428242); (R-GGA-1369062)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052555.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity;GO:0034041 ABC-type sterol transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0010008 endosome membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0010875 positive regulation of cholesterol efflux;GO:0055085 transmembrane transport;GO:0006355 regulation of DNA-templated transcription;GO:0033344 cholesterol efflux;GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P092-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P0A3-1", "uniprot_id": [ { "id": "A0A1D5P0A3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P0A3", "type": "external" } ], "mass": 6891.0, "length": 62, "protein_name": "Annexin", "gene_name": "LOC107049692", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC107049692", "gene_names_refseq": "", "protein_names_uniprotkb": "Annexin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PLX4", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P0A3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P0D0-1", "uniprot_id": [ { "id": "A0A1D5P0D0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P0D0", "type": "external" } ], "mass": 38821.0, "length": 333, "protein_name": "Alkyl transferase", "gene_name": "DHDDS", "organism": "Chicken", "refseq_name": "dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform 1", "refseq_ac": [ { "id": "NP_001376467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376467", "type": "external" } ], "gene_names_uniprotkb": "DHDDS", "gene_names_refseq": "DHDDS", "protein_names_uniprotkb": "Alkyl transferase; 2.5.1.-", "protein_names_refseq": "dehydrodolichyl diphosphate synthase complex subunit DHDDS isoform 1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-446199)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01023536.1, HAEK01055345.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000339.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; With NUS1, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery. Adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" }, { "id": "2.5.1.87", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.87", "type": "external" } ], "go_molecular_function": "GO:0045547 ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:1904423 dehydrodolichyl diphosphate synthase complex", "go_biological_process": "GO:0043048 dolichyl monophosphate biosynthetic process;GO:0006489 dolichyl diphosphate biosynthetic process;GO:0016094 polyprenol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P0D0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5NTY5-1", "uniprot_id": [ { "id": "A0A1D5NTY5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5NTY5", "type": "external" } ], "mass": 89311.0, "length": 806, "protein_name": "Transitional endoplasmic reticulum ATPase", "gene_name": "LOC430766", "organism": "Chicken", "refseq_name": "transitional endoplasmic reticulum ATPase isoform X2", "refseq_ac": [ { "id": "XP_025000347", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_025000347", "type": "external" } ], "gene_names_uniprotkb": "LOC430766", "gene_names_refseq": "LOC430766", "protein_names_uniprotkb": "Transitional endoplasmic reticulum ATPase; 3.6.4.6; Valosin-containing protein", "protein_names_refseq": "transitional endoplasmic reticulum ATPase isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:430766)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052571.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0008289 lipid binding;GO:0031593 polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006914 autophagy;GO:0097352 autophagosome maturation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051228 mitotic spindle disassembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5NTY5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PPW5-1", "uniprot_id": [ { "id": "A0A1D5PPW5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PPW5", "type": "external" } ], "mass": 100147.0, "length": 888, "protein_name": "Glutamate receptor", "gene_name": "GRIA3", "organism": "Chicken", "refseq_name": "glutamate receptor 3 isoform 1 precursor", "refseq_ac": [ { "id": "NP_001106270", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106270", "type": "external" } ], "gene_names_uniprotkb": "GRIA3", "gene_names_refseq": "GLUR-C; GLUR3/C; GLUR3; GRIA3", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "AMPA receptor GluR3/C; glutamate receptor 3 isoform 1 precursor; glutamate receptor 3; glutamate receptor C; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotropic, AMPA 3", "tax_id": 9031, "disease": "", "pathway": " (gga:396138); (R-GGA-399710); (R-GGA-416993); (R-GGA-438066); (R-GGA-8849932)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.116446.1, SRR12888504.9184.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## undergoes RNA editing :: PMID: 10688364 ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000071.1. On Sep 23, 2021 this sequence version replaced NP_001106270.1. Transcript Variant: This variant (1) encodes isoform 1 (also known as flip isoform). RNA editing (AGA->GGA) changes Arg769Gly., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0022824 transmitter-gated monoatomic ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0032281 AMPA glutamate receptor complex;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0051289 protein homotetramerization;GO:0035249 synaptic transmission, glutamatergic;GO:0051290 protein heterotetramerization;GO:0050804 modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PPW5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P2W2-1", "uniprot_id": [ { "id": "A0A1D5P2W2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P2W2", "type": "external" } ], "mass": 98309.0, "length": 879, "protein_name": "Extended synaptotagmin 2", "gene_name": "ESYT2", "organism": "Chicken", "refseq_name": "extended synaptotagmin-2 isoform X3", "refseq_ac": [ { "id": "XP_015137637", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015137637", "type": "external" } ], "gene_names_uniprotkb": "ESYT2", "gene_names_refseq": "ESYT2", "protein_names_uniprotkb": "Extended synaptotagmin 2", "protein_names_refseq": "extended synaptotagmin-2 isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:420451); (R-GGA-9845576)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008289 lipid binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0008429 phosphatidylethanolamine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0061817 endoplasmic reticulum-plasma membrane tethering;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P2W2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PAA8-1", "uniprot_id": [ { "id": "A0A1D5PAA8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PAA8", "type": "external" } ], "mass": 37201.0, "length": 332, "protein_name": "glycogenin glucosyltransferase", "gene_name": "GYG1", "organism": "Chicken", "refseq_name": "glycogenin-1", "refseq_ac": [ { "id": "NP_001006558", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006558", "type": "external" } ], "gene_names_uniprotkb": "GYG1", "gene_names_refseq": "GYG1; GYG; glycogenin-1", "protein_names_uniprotkb": "glycogenin glucosyltransferase; 2.4.1.186", "protein_names_refseq": "glycogenin-1", "tax_id": 9031, "disease": "", "pathway": " (gga:425050); (R-GGA-6798695); (R-GGA-70221)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01001753.1, AJ720384.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992437 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1. On Oct 4, 2021 this sequence version replaced NP_001006558.1., [RefSeq]; Glycogenin participates in the glycogen biosynthetic process along with glycogen synthase and glycogen branching enzyme. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" } ], "go_molecular_function": "GO:0008466 glycogenin glucosyltransferase activity;GO:0030145 manganese ion binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0005978 glycogen biosynthetic process;GO:0160249 glycogen biosynthetic process via UDP-glucose", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PAA8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PLF8-1", "uniprot_id": [ { "id": "A0A1D5PLF8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PLF8", "type": "external" } ], "mass": 9564.0, "length": 80, "protein_name": "Serine palmitoyltransferase small subunit B", "gene_name": "SPTSSB", "organism": "Chicken", "refseq_name": "serine palmitoyltransferase small subunit B isoform 1", "refseq_ac": [ { "id": "NP_001289040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289040", "type": "external" } ], "gene_names_uniprotkb": "SPTSSB", "gene_names_refseq": "C9H3orf57; SPTSSB", "protein_names_uniprotkb": "Serine palmitoyltransferase small subunit B; Protein ADMP; Small subunit of serine palmitoyltransferase B", "protein_names_refseq": "serine palmitoyltransferase small subunit B isoform 1", "tax_id": 9031, "disease": "", "pathway": " (gga:425008); (R-GGA-1660661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX930263.2, BU286144.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX930263.2 and CR353385.1. Transcript Variant: This variant (1) encodes the shorter isoform (1)., [RefSeq]; Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSB stimulates the catalytic activity and plays a role in substrate specificity. SPT complexes with this subunit showing a preference for longer acyl-CoAs. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0046513 ceramide biosynthetic process;GO:0007029 endoplasmic reticulum organization;GO:0006665 sphingolipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PLF8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PLH7-1", "uniprot_id": [ { "id": "A0A1D5PLH7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PLH7", "type": "external" } ], "mass": 29899.0, "length": 265, "protein_name": "thioredoxin-dependent peroxiredoxin", "gene_name": "PRDX4", "organism": "Chicken", "refseq_name": "peroxiredoxin-4 isoform X3", "refseq_ac": [ { "id": "XP_001234000", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001234000", "type": "external" } ], "gene_names_uniprotkb": "PRDX4", "gene_names_refseq": "PRDX4", "protein_names_uniprotkb": "thioredoxin-dependent peroxiredoxin; 1.11.1.24", "protein_names_refseq": "peroxiredoxin-4 isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:418601); (R-GGA-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 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}, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": 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}, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008379 thioredoxin peroxidase activity;GO:0140313 molecular sequestering activity;GO:0140824 thioredoxin-dependent peroxiredoxin activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0045454 cell redox homeostasis;GO:0042744 hydrogen peroxide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PLH7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PDM1-1", "uniprot_id": [ { "id": "A0A1D5PDM1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PDM1", "type": "external" } ], "mass": 48830.0, "length": 438, "protein_name": "Estrogen related receptor beta", "gene_name": "ESRRB", "organism": "Chicken", "refseq_name": "steroid hormone receptor ERR2 isoform X2", "refseq_ac": [ { "id": "XP_015143197", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015143197", "type": "external" } ], "gene_names_uniprotkb": "ESRRB", "gene_names_refseq": "ESRRB", "protein_names_uniprotkb": "Estrogen related receptor beta", "protein_names_refseq": "steroid hormone receptor ERR2 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:771938); (R-GGA-383280)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0005496 steroid binding;GO:0043565 sequence-specific DNA binding;GO:0034056 estrogen response element binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PDM1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PK45-1", "uniprot_id": [ { "id": "A0A1D5PK45_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PK45", "type": "external" } ], "mass": 42719.0, "length": 369, "protein_name": "ubiquitinyl hydrolase 1", "gene_name": "USP12", "organism": "Chicken", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 12 isoform X1", "refseq_ac": [ { "id": "XP_015134402", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015134402", "type": "external" } ], "gene_names_uniprotkb": "USP12", "gene_names_refseq": "USP12", "protein_names_uniprotkb": "ubiquitinyl hydrolase 1; 3.4.19.12", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 12 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:428078); (R-GGA-5689880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PK45-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PHP4-1", "uniprot_id": [ { "id": "A0A1D5PHP4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PHP4", "type": "external" } ], "mass": 148107.0, "length": 1265, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma", "gene_name": "PLCG2", "organism": "Chicken", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2", "refseq_ac": [ { "id": "XP_004944315", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004944315", "type": "external" } ], "gene_names_uniprotkb": "PLCG2", "gene_names_refseq": "PLCG2", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; 3.1.4.11", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:415805); (R-GGA-114604); (R-GGA-166016); (R-GGA-1855204); (R-GGA-202433); (R-GGA-2029485); (R-GGA-2424491); (R-GGA-2871796); (R-GGA-2871809); (R-GGA-5607764); (R-GGA-5621480); (R-GGA-983695)", "pathway_count": 12, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_004944315.1. COMPLETENESS: full length., [RefSeq]; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0001784 phosphotyrosine residue binding;GO:0097110 scaffold protein binding;GO:1990782 protein tyrosine kinase binding;GO:0140031 phosphorylation-dependent protein binding", "go_cellular_component": "GO:0045121 membrane raft;GO:0097708 intracellular vesicle;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0032587 ruffle membrane", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0035556 intracellular signal transduction;GO:0009395 phospholipid catabolic process;GO:1902533 positive regulation of intracellular signal transduction;GO:0032747 positive regulation of interleukin-23 production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PHP4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RMG2-1", "uniprot_id": [ { "id": "A0A1L1RMG2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RMG2", "type": "external" } ], "mass": 19173.0, "length": 168, "protein_name": "WW domain binding protein VOPP1", "gene_name": "VOPP1", "organism": "Chicken", "refseq_name": "vesicular, overexpressed in cancer, prosurvival protein 1 isoform X1", "refseq_ac": [ { "id": "XP_004939662", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004939662", "type": "external" } ], "gene_names_uniprotkb": "VOPP1", "gene_names_refseq": "VOPP1", "protein_names_uniprotkb": "WW domain binding protein VOPP1; Vesicular, overexpressed in cancer, prosurvival protein 1", "protein_names_refseq": "vesicular, overexpressed in cancer, prosurvival protein 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019899 enzyme binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RMG2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PA94-1", "uniprot_id": [ { "id": "A0A1D5PA94_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PA94", "type": "external" } ], "mass": 56553.0, "length": 506, "protein_name": "Potassium voltage-gated channel subfamily V member 1", "gene_name": "KCNV1", "organism": "Chicken", "refseq_name": "potassium voltage-gated channel subfamily V member 1", "refseq_ac": [ { "id": "XP_040520071", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040520071", "type": "external" } ], "gene_names_uniprotkb": "KCNV1", "gene_names_refseq": "KCNV1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily V member 1; Voltage-gated potassium channel subunit Kv8.1", "protein_names_refseq": "potassium voltage-gated channel subfamily V member 1", "tax_id": 9031, "disease": "", "pathway": " (gga:420278); (R-GGA-1296072)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052574.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PA94-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P0L8-1", "uniprot_id": [ { "id": "A0A1D5P0L8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P0L8", "type": "external" } ], "mass": 83083.0, "length": 758, "protein_name": "Junctophilin", "gene_name": "JPH3", "organism": "Chicken", "refseq_name": "junctophilin-3 isoform X1", "refseq_ac": [ { "id": "XP_015148144", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015148144", "type": "external" } ], "gene_names_uniprotkb": "JPH3", "gene_names_refseq": "JPH3", "protein_names_uniprotkb": "Junctophilin", "protein_names_refseq": "junctophilin-3 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:415830)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XP_015148144.1. COMPLETENESS: full length., [RefSeq]; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030314 junctional membrane complex", "go_biological_process": "GO:0007613 memory;GO:0035640 exploration behavior;GO:0048167 regulation of synaptic plasticity;GO:0048168 regulation of neuronal synaptic plasticity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P0L8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PZC6-1", "uniprot_id": [ { "id": "A0A1D5PZC6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PZC6", "type": "external" } ], "mass": 17348.0, "length": 153, "protein_name": "ORM1-like protein", "gene_name": "ORMDL2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ORMDL2", "gene_names_refseq": "", "protein_names_uniprotkb": "ORM1-like protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:425059); (R-GGA-1660661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:2000303 regulation of ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006672 ceramide metabolic process;GO:0090156 intracellular sphingolipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PZC6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PW06-1", "uniprot_id": [ { "id": "A0A1D5PW06_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PW06", "type": "external" } ], "mass": 27616.0, "length": 239, "protein_name": "Derlin", "gene_name": "DERL2", "organism": "Chicken", "refseq_name": "derlin-2", "refseq_ac": [ { "id": "XP_015151470", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015151470", "type": "external" } ], "gene_names_uniprotkb": "DERL2", "gene_names_refseq": "DERL2", "protein_names_uniprotkb": "Derlin", "protein_names_refseq": "derlin-2", "tax_id": 9031, "disease": "", "pathway": " (gga:417498); (R-GGA-382556); (R-GGA-5358346); (R-GGA-9931269)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052550.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005047 signal recognition particle binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005769 early endosome;GO:0005770 late endosome", "go_biological_process": "GO:0010498 proteasomal protein catabolic process;GO:0033554 cellular response to stress;GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PW06-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PAR5-1", "uniprot_id": [ { "id": "A0A1D5PAR5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PAR5", "type": "external" } ], "mass": 49956.0, "length": 449, "protein_name": "Tubulin alpha chain", "gene_name": "TUB5A", "organism": "Chicken", "refseq_name": "tubulin alpha-5 chain", "refseq_ac": [ { "id": "NP_001292069", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292069", "type": "external" } ], "gene_names_uniprotkb": "TUB5A", "gene_names_refseq": "TUB5A; TUBA2; TUBA3E; TUBA5", "protein_names_uniprotkb": "Tubulin alpha chain", "protein_names_refseq": "alpha tubulin; tubulin alpha-5 chain; tubulin alpha-8 chain; tubulin, alpha 2; tubulin, alpha 3e", "tax_id": 9031, "disease": "", "pathway": " (gga:421169)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01075199.1, HAEL01012169.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000356.1., [RefSeq]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0000226 microtubule cytoskeleton organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PAR5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PXF2-1", "uniprot_id": [ { "id": "A0A1D5PXF2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PXF2", "type": "external" } ], "mass": 36747.0, "length": 318, "protein_name": "Death effector domain-containing protein", "gene_name": "LOC121107542", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC121107542", "gene_names_refseq": "", "protein_names_uniprotkb": "Death effector domain-containing protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:425378)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:0006351 DNA-templated transcription;GO:0042981 regulation of apoptotic process;GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PXF2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RMS8-1", "uniprot_id": [ { "id": "A0A1L1RMS8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RMS8", "type": "external" } ], "mass": 12056.0, "length": 110, "protein_name": "ER membrane protein complex subunit 6", "gene_name": "EMC6", "organism": "Chicken", "refseq_name": "ER membrane protein complex subunit 6", "refseq_ac": [ { "id": "XP_001234671", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001234671", "type": "external" } ], "gene_names_uniprotkb": "EMC6", "gene_names_refseq": "EMC6", "protein_names_uniprotkb": "ER membrane protein complex subunit 6; Transmembrane protein 93", "protein_names_refseq": "ER membrane protein complex subunit 6", "tax_id": 9031, "disease": "", "pathway": " (gga:417604)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052550.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "R4GKV5", "ec_number_list": [], "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0072546 EMC complex;GO:1903349 omegasome membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RMS8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PCD1-1", "uniprot_id": [ { "id": "A0A1D5PCD1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PCD1", "type": "external" } ], "mass": 47236.0, "length": 428, "protein_name": "Flotillin", "gene_name": "FLOT2", "organism": "Chicken", "refseq_name": "flotillin-2 isoform 3", "refseq_ac": [ { "id": "NP_001383653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383653", "type": "external" } ], "gene_names_uniprotkb": "FLOT2", "gene_names_refseq": "FLOT2; flotillin-2", "protein_names_uniprotkb": "Flotillin", "protein_names_refseq": "flotillin-2 isoform 3", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-8980692); (R-GGA-9013026); (R-GGA-9013106); (R-GGA-9696264)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.20681.1, SRR13267660.11724.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000323.1. On Oct 25, 2021 this sequence version replaced XP_015151251.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane;GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0005912 adherens junction", "go_biological_process": "GO:0044860 protein localization to plasma membrane raft;GO:1903905 positive regulation of establishment of T cell polarity;GO:0010629 negative regulation of gene expression;GO:0072659 protein localization to plasma membrane;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PCD1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PK99-1", "uniprot_id": [ { "id": "A0A1D5PK99_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PK99", "type": "external" } ], "mass": 15218.0, "length": 124, "protein_name": "Mediator of RNA polymerase II transcription subunit 31", "gene_name": "MED31", "organism": "Chicken", "refseq_name": "mediator of RNA polymerase II transcription subunit 31", "refseq_ac": [ { "id": "NP_001308524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308524", "type": "external" } ], "gene_names_uniprotkb": "MED31", "gene_names_refseq": "MED31", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 31", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 31", "tax_id": 9031, "disease": "", "pathway": " (gga:417679); (R-GGA-9841922)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01046533.1, SRR13267659.256327.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000323.1. On Mar 27, 2016 this sequence version replaced XP_415924.1., [RefSeq]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PK99-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PDJ2-1", "uniprot_id": [ { "id": "A0A1D5PDJ2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PDJ2", "type": "external" } ], "mass": 17722.0, "length": 160, "protein_name": "Peripheral myelin protein 22", "gene_name": "PMP22", "organism": "Chicken", "refseq_name": "peripheral myelin protein 22", "refseq_ac": [ { "id": "NP_001264000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264000", "type": "external" } ], "gene_names_uniprotkb": "PMP22", "gene_names_refseq": "PMP22", "protein_names_uniprotkb": "Peripheral myelin protein 22", "protein_names_refseq": "peripheral myelin protein 22", "tax_id": 9031, "disease": "", "pathway": " (gga:417327)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.184385.1, SRR12888497.70377.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000316.1. On or before Mar 3, 2013 this sequence version replaced XP_001231973.1, XP_415595.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Might be involved in growth regulation, and in myelinization in the peripheral nervous system., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007399 nervous system development;GO:0006915 apoptotic process;GO:0032060 bleb assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PDJ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RPT1-1", "uniprot_id": [ { "id": "A0A1L1RPT1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RPT1", "type": "external" } ], "mass": 56410.0, "length": 491, "protein_name": "[histone H3]-lysine(4) N-trimethyltransferase", "gene_name": "SMYD1", "organism": "Chicken", "refseq_name": "histone-lysine N-methyltransferase SMYD1 isoform 1", "refseq_ac": [ { "id": "NP_989486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989486", "type": "external" } ], "gene_names_uniprotkb": "SMYD1", "gene_names_refseq": "BOP; SMYD1", "protein_names_uniprotkb": "[histone H3]-lysine(4) N-trimethyltransferase; 2.1.1.354; SET and MYND domain-containing protein 1", "protein_names_refseq": "CD8 beta opposite; SET and MYND domain-containing protein 1; histone-lysine N-methyltransferase SMYD1 isoform 1", "tax_id": 9031, "disease": "", "pathway": " (gga:373960)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01002244.1, HAEL01005269.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000077.1. On Nov 16, 2021 this sequence version replaced NP_989486.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0042800 histone H3K4 methyltransferase activity;GO:0140999 histone H3K4 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0045892 negative regulation of DNA-templated transcription;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RPT1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P2A3-1", "uniprot_id": [ { "id": "A0A1D5P2A3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P2A3", "type": "external" } ], "mass": 17368.0, "length": 150, "protein_name": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "gene_name": "PDE6D", "organism": "Chicken", "refseq_name": "retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1", "refseq_ac": [ { "id": "XP_015146985", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015146985", "type": "external" } ], "gene_names_uniprotkb": "PDE6D", "gene_names_refseq": "PDE6D", "protein_names_uniprotkb": "Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta", "protein_names_refseq": "retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:424932); (R-GGA-5624958)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052540.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide dissociation rate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005095 GTPase inhibitor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005856 cytoskeleton;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0007601 visual perception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P2A3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PFB0-1", "uniprot_id": [ { "id": "A0A1D5PFB0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PFB0", "type": "external" } ], "mass": 102484.0, "length": 908, "protein_name": "Glutamate receptor", "gene_name": "GRIK2", "organism": "Chicken", "refseq_name": "glutamate receptor ionotropic, kainate 2 isoform X4", "refseq_ac": [ { "id": "XP_040522487", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040522487", "type": "external" } ], "gene_names_uniprotkb": "GRIK2", "gene_names_refseq": "GRIK2", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "glutamate receptor ionotropic, kainate 2 isoform X4", "tax_id": 9031, "disease": "", "pathway": " (gga:428628); (R-GGA-451307)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052575.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity;GO:0022849 glutamate-gated calcium ion channel activity;GO:0005234 extracellularly glutamate-gated ion channel activity;GO:0015277 kainate selective glutamate receptor activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission;GO:0050806 positive regulation of synaptic transmission;GO:0120169 detection of cold stimulus involved in thermoception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PFB0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RPY6-1", "uniprot_id": [ { "id": "A0A1L1RPY6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RPY6", "type": "external" } ], "mass": 52149.0, "length": 445, "protein_name": "Eukaryotic translation initiation factor 3 subunit E", "gene_name": "EIF3E", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EIF3E; EIF3S6", "gene_names_refseq": "", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit E; Eukaryotic translation initiation factor 3 subunit 6; eIF3e", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:420272); (R-GGA-72649); (R-GGA-72695); (R-GGA-72702)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0016605 PML body;GO:0016282 eukaryotic 43S preinitiation complex", "go_biological_process": "GO:0006413 translational initiation;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045727 positive regulation of translation;GO:0001732 formation of cytoplasmic translation initiation complex", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RPY6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PC01-1", "uniprot_id": [ { "id": "A0A1D5PC01_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PC01", "type": "external" } ], "mass": 178076.0, "length": 1568, "protein_name": "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2", "gene_name": "SMARCA2", "organism": "Chicken", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2", "refseq_ac": [ { "id": "NP_001385284", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001385284", "type": "external" } ], "gene_names_uniprotkb": "SMARCA2", "gene_names_refseq": "BRM; SMARCA2", "protein_names_uniprotkb": "SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2", "protein_names_refseq": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2; probable global transcription activator SNF2L2", "tax_id": 9031, "disease": "", "pathway": " (gga:396040); (R-GGA-3214858); (R-GGA-8939243); (R-GGA-9933937); (R-GGA-9933939); (R-GGA-9933947); (R-GGA-9934037)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: X91638.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000089.1. On Dec 14, 2021 this sequence version replaced XP_040511371.1., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0042393 histone binding;GO:0003677 DNA binding;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0005634 nucleus;GO:0000785 chromatin", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0006355 regulation of DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PC01-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PC74-1", "uniprot_id": [ { "id": "A0A1D5PC74_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PC74", "type": "external" } ], "mass": 106197.0, "length": 920, "protein_name": "BCL2 associated transcription factor 1", "gene_name": "BCLAF1", "organism": "Chicken", "refseq_name": "bcl-2-associated transcription factor 1 isoform X1", "refseq_ac": [ { "id": "XP_004935768", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004935768", "type": "external" } ], "gene_names_uniprotkb": "BCLAF1", "gene_names_refseq": "BCLAF1", "protein_names_uniprotkb": "BCL2 associated transcription factor 1", "protein_names_refseq": "bcl-2-associated transcription factor 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:100858086)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_004935768.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003712 transcription coregulator activity;GO:0003729 mRNA binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0016592 mediator complex;GO:0005737 cytoplasm;GO:0035145 exon-exon junction complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006974 DNA damage response;GO:2001244 positive regulation of intrinsic apoptotic signaling pathway;GO:2000144 positive regulation of DNA-templated transcription initiation;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PC74-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PRM4-1", "uniprot_id": [ { "id": "A0A1D5PRM4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PRM4", "type": "external" } ], "mass": 161744.0, "length": 1437, "protein_name": "Protein strawberry notch homolog 2", "gene_name": "SBNO2", "organism": "Chicken", "refseq_name": "protein strawberry notch homolog 2 isoform X1", "refseq_ac": [ { "id": "XP_015155465", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015155465", "type": "external" } ], "gene_names_uniprotkb": "SBNO2", "gene_names_refseq": "SBNO2", "protein_names_uniprotkb": "Protein strawberry notch homolog 2", "protein_names_refseq": "protein strawberry notch homolog 2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:420104)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052559.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the pro-inflammatory cascade., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031490 chromatin DNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription;GO:0001503 ossification;GO:0071354 cellular response to interleukin-6", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PRM4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PT95-1", "uniprot_id": [ { "id": "A0A1D5PT95_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PT95", "type": "external" } ], "mass": 21660.0, "length": 189, "protein_name": "small monomeric GTPase", "gene_name": "KRAS", "organism": "Chicken", "refseq_name": "GTPase KRas isoform X1", "refseq_ac": [ { "id": "XP_015145733", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015145733", "type": "external" } ], "gene_names_uniprotkb": "KRAS", "gene_names_refseq": "KRAS", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "GTPase KRas isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:418207)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0003925 G protein activity;GO:0003924 GTPase activity;GO:0044877 protein-containing complex binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PT95-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P0N4-1", "uniprot_id": [ { "id": "A0A1D5P0N4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P0N4", "type": "external" } ], "mass": 84612.0, "length": 761, "protein_name": "Transcriptional activator Myb", "gene_name": "MYB", "organism": "Chicken", "refseq_name": "transcriptional activator Myb isoform X1", "refseq_ac": [ { "id": "XP_046769186", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046769186", "type": "external" } ], "gene_names_uniprotkb": "MYB", "gene_names_refseq": "MYB; c-myb", "protein_names_uniprotkb": "Transcriptional activator Myb", "protein_names_refseq": "transcriptional activator Myb isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052575.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0071987 WD40-repeat domain binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030218 erythrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P0N4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P0N6-1", "uniprot_id": [ { "id": "A0A1D5P0N6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P0N6", "type": "external" } ], "mass": 74927.0, "length": 644, "protein_name": "Anoctamin", "gene_name": "ANO10", "organism": "Chicken", "refseq_name": "anoctamin-10 isoform X1", "refseq_ac": [ { "id": "XP_004939487", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004939487", "type": "external" } ], "gene_names_uniprotkb": "ANO10", "gene_names_refseq": "ANO10", "protein_names_uniprotkb": "Anoctamin", "protein_names_refseq": "anoctamin-10 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:420674); (R-GGA-2672351)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005227 calcium-activated cation channel activity;GO:0005229 intracellularly calcium-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P0N6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P179-1", "uniprot_id": [ { "id": "A0A1D5P179_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P179", "type": "external" } ], "mass": 16778.0, "length": 144, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "gene_name": "NDUFA13", "organism": "Chicken", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "refseq_ac": [ { "id": "XP_015155603", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015155603", "type": "external" } ], "gene_names_uniprotkb": "NDUFA13", "gene_names_refseq": "NDUFA13", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "protein_names_refseq": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13", "tax_id": 9031, "disease": "", "pathway": " (gga:100859320); (R-GGA-611105); (R-GGA-6799198); (R-GGA-9837999)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052559.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Involved in the interferon/all-trans-retinoic acid (IFN/RA) induced cell death. This apoptotic activity is inhibited by interaction with viral IRF1. Prevents the transactivation of STAT3 target genes. May play a role in CARD15-mediated innate mucosal responses and serve to regulate intestinal epithelial cell responses to microbes., [UniProtKB, UniProtKB, UniProtKB]; Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P179-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P1F1-1", "uniprot_id": [ { "id": "A0A1D5P1F1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P1F1", "type": "external" } ], "mass": 68292.0, "length": 649, "protein_name": "sphingosine kinase", "gene_name": "SPHK1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SPHK1", "gene_names_refseq": "", "protein_names_uniprotkb": "sphingosine kinase; 2.7.1.91", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1660661); (R-GGA-390471); (R-GGA-5218921); (R-GGA-9009391); (R-GGA-9833482)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.91", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008481 sphingosine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0046512 sphingosine biosynthetic process;GO:0071363 cellular response to growth factor stimulus;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P1F1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P1F4-1", "uniprot_id": [ { "id": "A0A1D5P1F4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P1F4", "type": "external" } ], "mass": 37591.0, "length": 336, "protein_name": "E3 ubiquitin-protein ligase RING2", "gene_name": "RNF2", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase RING2", "refseq_ac": [ { "id": "XP_015146036", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015146036", "type": "external" } ], "gene_names_uniprotkb": "RNF2", "gene_names_refseq": "RNF2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RING2; 2.3.2.27; RING finger protein 1B; RING finger protein 2; RING-type E3 ubiquitin transferase RING2", "protein_names_refseq": "E3 ubiquitin-protein ligase RING2", "tax_id": 9031, "disease": "", "pathway": " (gga:424452); (R-GGA-2559580); (R-GGA-3108214); (R-GGA-3899300); (R-GGA-4551638); (R-GGA-4570464); (R-GGA-8939243); (R-GGA-8943724); (R-GGA-8953750)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052539.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0003682 chromatin binding;GO:0071535 RING-like zinc finger domain binding;GO:0140862 histone H2AK119 ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex;GO:0005694 chromosome;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007281 germ cell development;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P1F4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P1F5-1", "uniprot_id": [ { "id": "A0A1D5P1F5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P1F5", "type": "external" } ], "mass": 31437.0, "length": 281, "protein_name": "small monomeric GTPase", "gene_name": "RAB40C", "organism": "Chicken", "refseq_name": "ras-related protein Rab-40C", "refseq_ac": [ { "id": "NP_001166133", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166133", "type": "external" } ], "gene_names_uniprotkb": "RAB40C", "gene_names_refseq": "RAB40C", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-40C", "tax_id": 9031, "disease": "", "pathway": " (gga:769960)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: SRR12888486.570905.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. On Feb 25, 2010 this sequence version replaced XP_001233275.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity;GO:0003924 GTPase activity;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005811 lipid droplet", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016477 cell migration;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051895 negative regulation of focal adhesion assembly;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P1F5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P1L7-1", "uniprot_id": [ { "id": "A0A1D5P1L7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P1L7", "type": "external" } ], "mass": 105686.0, "length": 936, "protein_name": "Gamma-aminobutyric acid type B receptor subunit 2", "gene_name": "GABBR2", "organism": "Chicken", "refseq_name": "gamma-aminobutyric acid type B receptor subunit 2", "refseq_ac": [ { "id": "XP_015137885", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015137885", "type": "external" } ], "gene_names_uniprotkb": "GABBR2", "gene_names_refseq": "GABBR2", "protein_names_uniprotkb": "Gamma-aminobutyric acid type B receptor subunit 2", "protein_names_refseq": "gamma-aminobutyric acid type B receptor subunit 2", "tax_id": 9031, "disease": "", "pathway": " (gga:420979); (R-GGA-1296041); (R-GGA-997272)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0004965 G protein-coupled GABA receptor activity", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:1902710 GABA receptor complex;GO:0038039 G protein-coupled receptor heterodimeric complex", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007214 gamma-aminobutyric acid signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P1L7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P1M1-1", "uniprot_id": [ { "id": "A0A1D5P1M1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P1M1", "type": "external" } ], "mass": 108366.0, "length": 957, "protein_name": "Potassium voltage-gated channel subfamily H member 1", "gene_name": "KCNH1", "organism": "Chicken", "refseq_name": "potassium voltage-gated channel subfamily H member 1", "refseq_ac": [ { "id": "XP_040522344", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040522344", "type": "external" } ], "gene_names_uniprotkb": "KCNH1", "gene_names_refseq": "KCNH1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily H member 1", "protein_names_refseq": "potassium voltage-gated channel subfamily H member 1", "tax_id": 9031, "disease": "", "pathway": " (gga:421381); (R-GGA-1296072)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052575.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:1902936 phosphatidylinositol bisphosphate binding;GO:0005516 calmodulin binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031901 early endosome membrane;GO:0008076 voltage-gated potassium channel complex;GO:0098793 presynapse;GO:0034702 monoatomic ion channel complex", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0042391 regulation of membrane potential;GO:0071277 cellular response to calcium ion;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P1M1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P1T4-1", "uniprot_id": [ { "id": "A0A1D5P1T4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P1T4", "type": "external" } ], "mass": 206026.0, "length": 1843, "protein_name": "B-TFIID TATA-box binding protein associated factor 1", "gene_name": "BTAF1", "organism": "Chicken", "refseq_name": "TATA-binding protein-associated factor 172 isoform X1", "refseq_ac": [ { "id": "XP_015144314", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015144314", "type": "external" } ], "gene_names_uniprotkb": "BTAF1", "gene_names_refseq": "BTAF1", "protein_names_uniprotkb": "B-TFIID TATA-box binding protein associated factor 1", "protein_names_refseq": "TATA-binding protein-associated factor 172 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:423817)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052537.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003712 transcription coregulator activity;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P1T4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P1U2-1", "uniprot_id": [ { "id": "A0A1D5P1U2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P1U2", "type": "external" } ], "mass": 38877.0, "length": 359, "protein_name": "Pyruvate dehydrogenase E1 component subunit beta", "gene_name": "PDHB", "organism": "Chicken", "refseq_name": "pyruvate dehydrogenase E1 component subunit beta, mitochondrial", "refseq_ac": [ { "id": "NP_001185549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185549", "type": "external" } ], "gene_names_uniprotkb": "PDHB", "gene_names_refseq": "PDHB", "protein_names_uniprotkb": "Pyruvate dehydrogenase E1 component subunit beta; 1.2.4.1", "protein_names_refseq": "pyruvate dehydrogenase E1 component subunit beta, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (gga:416066); (R-GGA-204174); (R-GGA-5362517); (R-GGA-9837999); (R-GGA-9861559)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01086922.1, BX933955.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000252.1. On or before Feb 10, 2016 this sequence version replaced XP_015148593.1, XP_414404.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2., [UniProtKB, UniProtKB, UniProtKB]; Together with PDHA1 forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex. The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "4.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.2", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P1U2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P1U8-1", "uniprot_id": [ { "id": "A0A1D5P1U8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P1U8", "type": "external" } ], "mass": 118763.0, "length": 1033, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 48", "gene_name": "USP48", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "USP48", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 48; 3.4.19.12", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:769457); (R-GGA-5689880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P1U8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P9H5-1", "uniprot_id": [ { "id": "A0A1D5P9H5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P9H5", "type": "external" } ], "mass": 112101.0, "length": 981, "protein_name": "Ubiquitin carboxyl-terminal hydrolase", "gene_name": "USP15", "organism": "Chicken", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 15 isoform 1", "refseq_ac": [ { "id": "NP_990171", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990171", "type": "external" } ], "gene_names_uniprotkb": "USP15", "gene_names_refseq": "UNP; USP15", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase; 3.4.19.12", "protein_names_refseq": "ubiquitin carboxyl-terminal hydrolase 15 isoform 1; ubiquitin carboxyl-terminal hydrolase 15; ubiquitin specific protease 15; ubiquitous nuclear protein", "tax_id": 9031, "disease": "", "pathway": " (gga:395644); (R-GGA-5689880)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "10444327;12532266", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267654.224165.1, SRR13267652.2516.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from JAENSK010000012.1. On Oct 4, 2004 this sequence version replaced NP_990171.1. This gene encodes a protein that is a member of the ubiquitin-specific protease (UBP) family, one of two deubiquitinating enzyme families. Members of the UBP family are characterized by the presence of two conserved motifs, the Cys box and the His box, thought to form part of the active site for these proteases. Deubiquitinating enzymes can cleave either the ubiquitin fusion protein precursors to produce free ubiquitin, or they can cleave ubiquitinated proteins. Proteins are ubiquitinated to target them for degradation, or to target them for a specific cellular location or fate. Two alternative transcripts encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcripts from different strains and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Details changes in nomenclature for human and orthologous USPs, [RefSeq, PubMed]; Identification of UNP (AF105715.1) as USP15 and not USP4, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:0061649 ubiquitin-modified histone reader activity;GO:0005160 transforming growth factor beta receptor binding;GO:0046332 SMAD binding;GO:0004197 cysteine-type endopeptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0051252 regulation of RNA metabolic process;GO:1905035 negative regulation of antifungal innate immune response;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1D5P9H5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P1V7-1", "uniprot_id": [ { "id": "A0A1D5P1V7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P1V7", "type": "external" } ], "mass": 78386.0, "length": 711, "protein_name": "Cytoplasmic polyadenylation element binding protein 4", "gene_name": "CPEB4", "organism": "Chicken", "refseq_name": "cytoplasmic polyadenylation element-binding protein 4 isoform X1", "refseq_ac": [ { "id": "XP_414678", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_414678", "type": "external" } ], "gene_names_uniprotkb": "CPEB4", "gene_names_refseq": "CPEB4", "protein_names_uniprotkb": "Cytoplasmic polyadenylation element binding protein 4", "protein_names_refseq": "cytoplasmic polyadenylation element-binding protein 4 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:416363)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_414678.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0008135 translation factor activity, RNA binding;GO:0043022 ribosome binding;GO:0003730 mRNA 3'-UTR binding;GO:0045182 translation regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045202 synapse;GO:0043005 neuron projection", "go_biological_process": "GO:2000766 negative regulation of cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P1V7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P1W7-1", "uniprot_id": [ { "id": "A0A1D5P1W7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P1W7", "type": "external" } ], "mass": 97333.0, "length": 876, "protein_name": "Karyopherin subunit beta 1", "gene_name": "KPNB1", "organism": "Chicken", "refseq_name": "importin subunit beta-1", "refseq_ac": [ { "id": "XP_015154959", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015154959", "type": "external" } ], "gene_names_uniprotkb": "KPNB1", "gene_names_refseq": "KPNB1", "protein_names_uniprotkb": "Karyopherin subunit beta 1", "protein_names_refseq": "importin subunit beta-1", "tax_id": 9031, "disease": "", "pathway": " (gga:426499); (R-GGA-140342); (R-GGA-1655829); (R-GGA-2995383); (R-GGA-6798695); (R-GGA-68616); (R-GGA-909733)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052558.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0061676 importin-alpha family protein binding;GO:0019904 protein domain specific binding;GO:0051879 Hsp90 protein binding;GO:0008139 nuclear localization sequence binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006606 protein import into nucleus;GO:0007079 mitotic chromosome movement towards spindle pole;GO:0006610 ribosomal protein import into nucleus;GO:0090307 mitotic spindle assembly;GO:0007080 mitotic metaphase chromosome alignment", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P1W7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P201-1", "uniprot_id": [ { "id": "A0A1D5P201_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P201", "type": "external" } ], "mass": 55727.0, "length": 479, "protein_name": "2-phosphoxylose phosphatase 1", "gene_name": "PXYLP1", "organism": "Chicken", "refseq_name": "2-phosphoxylose phosphatase 1 isoform X2", "refseq_ac": [ { "id": "XP_015132523", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015132523", "type": "external" } ], "gene_names_uniprotkb": "PXYLP1", "gene_names_refseq": "PXYLP1", "protein_names_uniprotkb": "2-phosphoxylose phosphatase 1; Acid phosphatase-like protein 2", "protein_names_refseq": "2-phosphoxylose phosphatase 1 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:424815); (R-GGA-1971475)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052540.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "R4GK89", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0016791 phosphatase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0010909 positive regulation of heparan sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P201-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P284-1", "uniprot_id": [ { "id": "A0A1D5P284_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P284", "type": "external" } ], "mass": 199982.0, "length": 1751, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "UBR2", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase UBR2 isoform X2", "refseq_ac": [ { "id": "XP_419446", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_419446", "type": "external" } ], "gene_names_uniprotkb": "UBR2", "gene_names_refseq": "UBR2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase UBR2 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:421387); (R-GGA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_419446.2. COMPLETENESS: full length., [RefSeq]; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0070728 L-leucine binding;GO:0141053 histone H2A ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway;GO:0050862 positive regulation of T cell receptor signaling pathway;GO:0032007 negative regulation of TOR signaling;GO:0007140 male meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P284-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P2G3-1", "uniprot_id": [ { "id": "A0A1D5P2G3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P2G3", "type": "external" } ], "mass": 51112.0, "length": 452, "protein_name": "Ethanolamine kinase", "gene_name": "CHKA", "organism": "Chicken", "refseq_name": "choline kinase alpha isoform X1", "refseq_ac": [ { "id": "XP_040529108", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040529108", "type": "external" } ], "gene_names_uniprotkb": "CHKA", "gene_names_refseq": "CHKA", "protein_names_uniprotkb": "Ethanolamine kinase; 2.7.1.32; 2.7.1.82", "protein_names_refseq": "choline kinase alpha isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:423112); (R-GGA-1483191); (R-GGA-1483213)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052577.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32", "type": "external" }, { "id": "2.7.1.82", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0004103 choline kinase activity;GO:0004305 ethanolamine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006657 CDP-choline pathway;GO:0006646 phosphatidylethanolamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P2G3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P2I2-1", "uniprot_id": [ { "id": "A0A1D5P2I2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P2I2", "type": "external" } ], "mass": 49241.0, "length": 435, "protein_name": "Phospholipid/glycerol acyltransferase domain-containing protein", "gene_name": "AGPAT5L", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AGPAT5L", "gene_names_refseq": "", "protein_names_uniprotkb": "Phospholipid/glycerol acyltransferase domain-containing protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:422609)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P2I2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P2L3-1", "uniprot_id": [ { "id": "A0A1D5P2L3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P2L3", "type": "external" } ], "mass": 89692.0, "length": 776, "protein_name": "Cullin-1", "gene_name": "CUL1", "organism": "Chicken", "refseq_name": "cullin-1 isoform X1", "refseq_ac": [ { "id": "XP_015131393", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015131393", "type": "external" } ], "gene_names_uniprotkb": "CUL1", "gene_names_refseq": "CUL1", "protein_names_uniprotkb": "Cullin-1", "protein_names_refseq": "cullin-1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:420783); (R-GGA-1170546); (R-GGA-174113); (R-GGA-187577); (R-GGA-195253); (R-GGA-5610780); (R-GGA-5610785); (R-GGA-68949); (R-GGA-69231); (R-GGA-69601); (R-GGA-8854050); (R-GGA-8939902); (R-GGA-8951664); (R-GGA-9020702); (R-GGA-917937); (R-GGA-9762114); (R-GGA-983168); (R-GGA-9929356)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0160072 ubiquitin ligase complex scaffold activity", "go_cellular_component": "GO:0019005 SCF ubiquitin ligase complex;GO:0031461 cullin-RING ubiquitin ligase complex;GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex;GO:0005634 nucleus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006915 apoptotic process;GO:0070936 protein K48-linked ubiquitination;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P2L3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P2V4-1", "uniprot_id": [ { "id": "A0A1D5P2V4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P2V4", "type": "external" } ], "mass": 10353.0, "length": 89, "protein_name": "Dynein light chain", "gene_name": "LOC100858984", "organism": "Chicken", "refseq_name": "dynein light chain 2, cytoplasmic", "refseq_ac": [ { "id": "XP_003642262", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003642262", "type": "external" } ], "gene_names_uniprotkb": "LOC100858984", "gene_names_refseq": "LOC100858984", "protein_names_uniprotkb": "Dynein light chain", "protein_names_refseq": "dynein light chain 2, cytoplasmic", "tax_id": 9031, "disease": "", "pathway": " (gga:100858984)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052546.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045505 dynein intermediate chain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process;GO:0006974 DNA damage response;GO:0044458 motile cilium assembly;GO:0035721 intraciliary retrograde transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P2V4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P2V9-1", "uniprot_id": [ { "id": "A0A1D5P2V9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P2V9", "type": "external" } ], "mass": 36912.0, "length": 324, "protein_name": "Olfactory receptor", "gene_name": "LOC101750836", "organism": "Chicken", "refseq_name": "olfactory receptor 1020-like", "refseq_ac": [ { "id": "XP_004943663", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004943663", "type": "external" } ], "gene_names_uniprotkb": "LOC101750836", "gene_names_refseq": "LOC101750836", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 1020-like", "tax_id": 9031, "disease": "", "pathway": " (gga:101750836)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 5% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052541.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0050911 detection of chemical stimulus involved in sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P2V9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P2X5-1", "uniprot_id": [ { "id": "A0A1D5P2X5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P2X5", "type": "external" } ], "mass": 73981.0, "length": 658, "protein_name": "protein-tyrosine-phosphatase", "gene_name": "PTPRR", "organism": "Chicken", "refseq_name": "receptor-type tyrosine-protein phosphatase R isoform X3", "refseq_ac": [ { "id": "XP_001235188", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001235188", "type": "external" } ], "gene_names_uniprotkb": "PTPRR", "gene_names_refseq": "PTPRR", "protein_names_uniprotkb": "protein-tyrosine-phosphatase; 3.1.3.48", "protein_names_refseq": "receptor-type tyrosine-protein phosphatase R isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:771985)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_001235188.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0012505 endomembrane system", "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0007165 signal transduction;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0038128 ERBB2 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P2X5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P312-1", "uniprot_id": [ { "id": "A0A1D5P312_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P312", "type": "external" } ], "mass": 9928.0, "length": 98, "protein_name": "Keratin", "gene_name": "LOC124417025", "organism": "Chicken", "refseq_name": "feather keratin 1-like", "refseq_ac": [ { "id": "XP_046768403", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046768403", "type": "external" } ], "gene_names_uniprotkb": "LOC124417025", "gene_names_refseq": "LOC124417025", "protein_names_uniprotkb": "Keratin", "protein_names_refseq": "feather keratin 1-like", "tax_id": 9031, "disease": "", "pathway": " (gga:100859039); (gga:107052813); (gga:420291)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052574.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P312-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P316-1", "uniprot_id": [ { "id": "A0A1D5P316_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P316", "type": "external" } ], "mass": 15318.0, "length": 132, "protein_name": "Pleckstrin homology-like domain family A member 2", "gene_name": "PHLDA2", "organism": "Chicken", "refseq_name": "pleckstrin homology-like domain family A member 2", "refseq_ac": [ { "id": "NP_001186524", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186524", "type": "external" } ], "gene_names_uniprotkb": "PHLDA2", "gene_names_refseq": "PHLDA2", "protein_names_uniprotkb": "Pleckstrin homology-like domain family A member 2; Imprinted in placenta and liver protein", "protein_names_refseq": "pleckstrin homology-like domain family A member 2", "tax_id": 9031, "disease": "", "pathway": " (gga:423088)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01118740.1, HAEK01133157.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000214.1. On Dec 10, 2010 this sequence version replaced XP_421020.1., [RefSeq]; Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P316-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P363-1", "uniprot_id": [ { "id": "A0A1D5P363_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P363", "type": "external" } ], "mass": 21085.0, "length": 194, "protein_name": "Cerebellin 1", "gene_name": "CBLN1", "organism": "Chicken", "refseq_name": "cerebellin-1", "refseq_ac": [ { "id": "XP_015147896", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015147896", "type": "external" } ], "gene_names_uniprotkb": "CBLN1", "gene_names_refseq": "CBLN1", "protein_names_uniprotkb": "Cerebellin 1", "protein_names_refseq": "cerebellin-1", "tax_id": 9031, "disease": "", "pathway": " (gga:771265)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XP_015147896.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030545 signaling receptor regulator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0045211 postsynaptic membrane;GO:0043083 synaptic cleft;GO:0098688 parallel fiber to Purkinje cell synapse", "go_biological_process": "GO:0099558 maintenance of synapse structure;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0099557 trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission;GO:0099550 trans-synaptic signaling, modulating synaptic transmission;GO:0021707 cerebellar granule cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P363-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P370-1", "uniprot_id": [ { "id": "A0A1D5P370_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P370", "type": "external" } ], "mass": 32533.0, "length": 295, "protein_name": "Homeobox C13", "gene_name": "HOXC13", "organism": "Chicken", "refseq_name": "homeobox protein Hox-C13", "refseq_ac": [ { "id": "XP_001235166", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001235166", "type": "external" } ], "gene_names_uniprotkb": "HOXC13", "gene_names_refseq": "HOXC13", "protein_names_uniprotkb": "Homeobox C13", "protein_names_refseq": "homeobox protein Hox-C13", "tax_id": 9031, "disease": "", "pathway": " (gga:771955)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052565.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XP_001235166.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P370-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P3B1-1", "uniprot_id": [ { "id": "A0A1D5P3B1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P3B1", "type": "external" } ], "mass": 20233.0, "length": 178, "protein_name": "Large ribosomal subunit protein uL5", "gene_name": "RPL11", "organism": "Chicken", "refseq_name": "large ribosomal subunit protein uL5", "refseq_ac": [ { "id": "NP_001292117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292117", "type": "external" } ], "gene_names_uniprotkb": "RPL11", "gene_names_refseq": "RPL11", "protein_names_uniprotkb": "Large ribosomal subunit protein uL5; 60S ribosomal protein L11", "protein_names_refseq": "60S ribosomal protein L11; large ribosomal subunit protein uL5", "tax_id": 9031, "disease": "", "pathway": " (gga:419682); (R-GGA-1799339); (R-GGA-72706); (R-GGA-975956); (R-GGA-975957); (R-GGA-9954709); (R-GGA-9954714); (R-GGA-9954716)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "23563180;38395592", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AL584321.1, AJ393053.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000339.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; The existence of ribosomes with different protein components, notably ribosomes devoid of RPL11, and a regulation of mRNA translation depending on v-erbA oncogene expression, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome;GO:0003723 RNA binding;GO:0031625 ubiquitin protein ligase binding;GO:1990948 ubiquitin ligase inhibitor activity", "go_cellular_component": "GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0006605 protein targeting;GO:0034504 protein localization to nucleus;GO:0006364 rRNA processing;GO:1901798 positive regulation of signal transduction by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1D5P3B1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P3F4-1", "uniprot_id": [ { "id": "A0A1D5P3F4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P3F4", "type": "external" } ], "mass": 44722.0, "length": 395, "protein_name": "Thyrotropin-releasing hormone receptor", "gene_name": "TRHR", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TRHR", "gene_names_refseq": "", "protein_names_uniprotkb": "Thyrotropin-releasing hormone receptor; Thyroliberin receptor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-375276); (R-GGA-416476)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004997 thyrotropin-releasing hormone receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P3F4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P3K4-1", "uniprot_id": [ { "id": "A0A1D5P3K4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P3K4", "type": "external" } ], "mass": 20125.0, "length": 172, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "gene_name": "NDUFA8", "organism": "Chicken", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform 1", "refseq_ac": [ { "id": "NP_001264584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264584", "type": "external" } ], "gene_names_uniprotkb": "NDUFA8", "gene_names_refseq": "NDUFA8", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform 1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8", "tax_id": 9031, "disease": "", "pathway": " (gga:417112); (R-GGA-611105); (R-GGA-6799198)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU279435.1, HAEK01186125.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000308.1. On Apr 13, 2013 this sequence version replaced XP_415397.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same breed was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P3K4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P3M7-1", "uniprot_id": [ { "id": "A0A1D5P3M7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P3M7", "type": "external" } ], "mass": 39880.0, "length": 350, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "RNF165", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase RNF165", "refseq_ac": [ { "id": "XP_414696", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_414696", "type": "external" } ], "gene_names_uniprotkb": "RNF165", "gene_names_refseq": "RNF165", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF165", "tax_id": 9031, "disease": "", "pathway": " (gga:416382)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 19, 2013 this sequence version replaced XP_414696.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030513 positive regulation of BMP signaling pathway;GO:0008045 motor neuron axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P3M7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P3Q1-1", "uniprot_id": [ { "id": "A0A1D5P3Q1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P3Q1", "type": "external" } ], "mass": 52304.0, "length": 464, "protein_name": "Carbohydrate sulfotransferase 7", "gene_name": "CHST7", "organism": "Chicken", "refseq_name": "carbohydrate sulfotransferase 7", "refseq_ac": [ { "id": "XP_015133248", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015133248", "type": "external" } ], "gene_names_uniprotkb": "CHST7", "gene_names_refseq": "CHST7", "protein_names_uniprotkb": "Carbohydrate sulfotransferase 7", "protein_names_refseq": "carbohydrate sulfotransferase 7", "tax_id": 9031, "disease": "", "pathway": " (gga:107051963); (R-GGA-2022870)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity;GO:0008459 chondroitin 6-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0006044 N-acetylglucosamine metabolic process;GO:0005975 carbohydrate metabolic process;GO:0006790 sulfur compound metabolic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P3Q1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P3S1-1", "uniprot_id": [ { "id": "A0A1D5P3S1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P3S1", "type": "external" } ], "mass": 184947.0, "length": 1636, "protein_name": "HECT-type E3 ubiquitin transferase", "gene_name": "HECW1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HECW1", "gene_names_refseq": "", "protein_names_uniprotkb": "HECT-type E3 ubiquitin transferase; 2.3.2.26", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-4641258)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0048814 regulation of dendrite morphogenesis;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P3S1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P3W4-1", "uniprot_id": [ { "id": "A0A1D5P3W4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P3W4", "type": "external" } ], "mass": 64134.0, "length": 580, "protein_name": "long-chain-fatty-acid--CoA ligase", "gene_name": "SLC27A2", "organism": "Chicken", "refseq_name": "bile acyl-CoA synthetase isoform X2", "refseq_ac": [ { "id": "XP_046760790", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046760790", "type": "external" } ], "gene_names_uniprotkb": "SLC27A2", "gene_names_refseq": "SLC27A2", "protein_names_uniprotkb": "long-chain-fatty-acid--CoA ligase; 6.2.1.3; Long-chain-fatty-acid--CoA ligase", "protein_names_refseq": "bile acyl-CoA synthetase isoform X2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-159418); (R-GGA-193368); (R-GGA-193775); (R-GGA-389599); (R-GGA-390247); (R-GGA-6798695); (R-GGA-75105); (R-GGA-9033241)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052562.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0000166 nucleotide binding;GO:0004467 long-chain fatty acid-CoA ligase activity;GO:0031957 very long-chain fatty acid-CoA ligase activity;GO:0047747 cholate-CoA ligase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000038 very long-chain fatty acid metabolic process;GO:0001676 long-chain fatty acid metabolic process;GO:0006699 bile acid biosynthetic process;GO:0044539 long-chain fatty acid import into cell;GO:0008206 bile acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P3W4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P3Y4-1", "uniprot_id": [ { "id": "A0A1D5P3Y4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P3Y4", "type": "external" } ], "mass": 24996.0, "length": 216, "protein_name": "Large ribosomal subunit protein uL24m", "gene_name": "MRPL24", "organism": "Chicken", "refseq_name": "39S ribosomal protein L24, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_015153911", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015153911", "type": "external" } ], "gene_names_uniprotkb": "MRPL24", "gene_names_refseq": "MRPL24", "protein_names_uniprotkb": "Large ribosomal subunit protein uL24m; 39S ribosomal protein L24, mitochondrial", "protein_names_refseq": "39S ribosomal protein L24, mitochondrial isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:768957); (R-GGA-5389840); (R-GGA-5419276); (R-GGA-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052556.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 1, 2022 this sequence version replaced XP_015153911.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P3Y4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P3Y5-1", "uniprot_id": [ { "id": "A0A1D5P3Y5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P3Y5", "type": "external" } ], "mass": 33042.0, "length": 288, "protein_name": "BTB/POZ domain-containing protein KCTD7", "gene_name": "KCTD7", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KCTD7", "gene_names_refseq": "", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD7", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-8951664); (R-GGA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0060081 membrane hyperpolarization;GO:0030007 intracellular potassium ion homeostasis;GO:0090461 intracellular glutamate homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P3Y5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P3Z3-1", "uniprot_id": [ { "id": "A0A1D5P3Z3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P3Z3", "type": "external" } ], "mass": 77719.0, "length": 690, "protein_name": "DDHD domain containing 2", "gene_name": "DDHD2", "organism": "Chicken", "refseq_name": "phospholipase DDHD2 isoform X3", "refseq_ac": [ { "id": "XP_015152905", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015152905", "type": "external" } ], "gene_names_uniprotkb": "DDHD2", "gene_names_refseq": "DDHD2", "protein_names_uniprotkb": "DDHD domain containing 2", "protein_names_refseq": "phospholipase DDHD2 isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:426777); (R-GGA-1483166)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052553.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004620 phospholipase activity;GO:0004806 triacylglycerol lipase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0030134 COPII-coated ER to Golgi transport vesicle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P3Z3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P405-1", "uniprot_id": [ { "id": "A0A1D5P405_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P405", "type": "external" } ], "mass": 67853.0, "length": 596, "protein_name": "Growth factor receptor bound protein 10", "gene_name": "GRB10", "organism": "Chicken", "refseq_name": "growth factor receptor-bound protein 10", "refseq_ac": [ { "id": "NP_001034371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034371", "type": "external" } ], "gene_names_uniprotkb": "GRB10", "gene_names_refseq": "GRB10", "protein_names_uniprotkb": "Growth factor receptor bound protein 10", "protein_names_refseq": "adapter protein; binds to insulin receptor and IGF1R; growth factor receptor-bound protein 10", "tax_id": 9031, "disease": "", "pathway": " (gga:420948); (R-GGA-1433557); (R-GGA-74713); (R-GGA-74749); (R-GGA-74751); (R-GGA-8853659); (R-GGA-9607240)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267654.16196.1, SRR13267656.19821.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000041.1. On Jul 10, 2015 this sequence version replaced NP_001034371.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0008286 insulin receptor signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway;GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P405-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P437-1", "uniprot_id": [ { "id": "A0A1D5P437_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P437", "type": "external" } ], "mass": 42474.0, "length": 364, "protein_name": "ArfGAP with dual PH domains 2", "gene_name": "ADAP2", "organism": "Chicken", "refseq_name": "arf-GAP with dual PH domain-containing protein 2", "refseq_ac": [ { "id": "XP_415661", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_415661", "type": "external" } ], "gene_names_uniprotkb": "ADAP2", "gene_names_refseq": "ADAP2", "protein_names_uniprotkb": "ArfGAP with dual PH domains 2", "protein_names_refseq": "arf-GAP with dual PH domain-containing protein 2", "tax_id": 9031, "disease": "", "pathway": " (gga:417409)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052549.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1902936 phosphatidylinositol bisphosphate binding;GO:0005096 GTPase activator activity;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0008270 zinc ion binding;GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0007507 heart development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P437-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P480-1", "uniprot_id": [ { "id": "A0A1D5P480_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P480", "type": "external" } ], "mass": 27622.0, "length": 258, "protein_name": "Insulin-like growth factor-binding protein 4", "gene_name": "IGFBP4", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IGFBP4", "gene_names_refseq": "", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-381426); (R-GGA-8957275)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0043567 regulation of insulin-like growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P480-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PNP5-1", "uniprot_id": [ { "id": "A0A1D5PNP5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PNP5", "type": "external" } ], "mass": 105261.0, "length": 949, "protein_name": "Netrin receptor UNC5", "gene_name": "UNC5D", "organism": "Chicken", "refseq_name": "netrin receptor UNC5D isoform X1", "refseq_ac": [ { "id": "XP_424529", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_424529", "type": "external" } ], "gene_names_uniprotkb": "UNC5D", "gene_names_refseq": "UNC5D", "protein_names_uniprotkb": "Netrin receptor UNC5", "protein_names_refseq": "netrin receptor UNC5D isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:426920)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052553.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 19, 2013 this sequence version replaced XP_424529.3. COMPLETENESS: full length., [RefSeq]; Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005042 netrin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PNP5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PG02-1", "uniprot_id": [ { "id": "A0A1D5PG02_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PG02", "type": "external" } ], "mass": 52241.0, "length": 485, "protein_name": "Solute carrier family 41 member", "gene_name": "SLC41A3", "organism": "Chicken", "refseq_name": "solute carrier family 41 member 3 isoform X1", "refseq_ac": [ { "id": "XP_004944660", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004944660", "type": "external" } ], "gene_names_uniprotkb": "SLC41A3", "gene_names_refseq": "SLC41A3", "protein_names_uniprotkb": "Solute carrier family 41 member", "protein_names_refseq": "solute carrier family 41 member 3 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:416033)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052543.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Acts as a magnesium transporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008324 monoatomic cation transmembrane transporter activity;GO:0061768 magnesium:sodium antiporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0030001 metal ion transport;GO:0045016 mitochondrial magnesium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PG02-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P4Q8-1", "uniprot_id": [ { "id": "A0A1D5P4Q8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P4Q8", "type": "external" } ], "mass": 20854.0, "length": 183, "protein_name": "Protein jagunal homolog 1", "gene_name": "JAGN1", "organism": "Chicken", "refseq_name": "protein jagunal homolog 1", "refseq_ac": [ { "id": "NP_001378843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001378843", "type": "external" } ], "gene_names_uniprotkb": "JAGN1", "gene_names_refseq": "JAGN1", "protein_names_uniprotkb": "Protein jagunal homolog 1", "protein_names_refseq": "protein jagunal homolog 1", "tax_id": 9031, "disease": "", "pathway": " (gga:416052)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01057548.1, BU256659.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000252.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030223 neutrophil differentiation;GO:0002446 neutrophil mediated immunity;GO:0016192 vesicle-mediated transport;GO:0050832 defense response to fungus;GO:0038158 granulocyte colony-stimulating factor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P4Q8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P4S3-1", "uniprot_id": [ { "id": "A0A1D5P4S3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P4S3", "type": "external" } ], "mass": 76846.0, "length": 679, "protein_name": "Interleukin-1 receptor accessory protein", "gene_name": "IL1RAP", "organism": "Chicken", "refseq_name": "interleukin-1 receptor accessory protein isoform X4", "refseq_ac": [ { "id": "XP_015147068", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015147068", "type": "external" } ], "gene_names_uniprotkb": "IL1RAP", "gene_names_refseq": "IL1RAP", "protein_names_uniprotkb": "Interleukin-1 receptor accessory protein", "protein_names_refseq": "interleukin-1 receptor accessory protein isoform X4", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-388844); (R-GGA-9020702)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052540.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002114 interleukin-33 receptor activity;GO:0015026 coreceptor activity;GO:0016787 hydrolase activity;GO:0004908 interleukin-1 receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0070498 interleukin-1-mediated signaling pathway;GO:0006954 inflammatory response;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P4S3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P4W1-1", "uniprot_id": [ { "id": "A0A1D5P4W1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P4W1", "type": "external" } ], "mass": 63591.0, "length": 561, "protein_name": "TBC1 domain family member 24", "gene_name": "TBC1D24", "organism": "Chicken", "refseq_name": "TBC1 domain family member 24", "refseq_ac": [ { "id": "NP_001244200", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001244200", "type": "external" } ], "gene_names_uniprotkb": "TBC1D24", "gene_names_refseq": "TBC1D24", "protein_names_uniprotkb": "TBC1 domain family member 24", "protein_names_refseq": "TBC1 domain family member 24", "tax_id": 9031, "disease": "", "pathway": " (gga:100859828); (R-GGA-8854214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## CDS exon combination :: HAEK01085219.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMEA103992482, SAMN02738218 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000257.1. On Mar 25, 2012 this sequence version replaced XP_003642217.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; May act as a GTPase-activating protein for Rab family protein(s). Involved in neuronal projections development, probably through a negative modulation of ARF6 function. Involved in the regulation of synaptic vesicle trafficking., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0098793 presynapse", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0048666 neuron development;GO:0120036 plasma membrane bounded cell projection organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P4W1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P4Z5-1", "uniprot_id": [ { "id": "A0A1D5P4Z5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P4Z5", "type": "external" } ], "mass": 24363.0, "length": 223, "protein_name": "Peflin", "gene_name": "PEF1", "organism": "Chicken", "refseq_name": "peflin", "refseq_ac": [ { "id": "XP_417792", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_417792", "type": "external" } ], "gene_names_uniprotkb": "PEF1", "gene_names_refseq": "PEF1", "protein_names_uniprotkb": "Peflin; PEF protein with a long N-terminal hydrophobic domain; Penta-EF hand domain-containing protein 1", "protein_names_refseq": "peflin", "tax_id": 9031, "disease": "", "pathway": " (gga:419644)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052554.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0014029 neural crest formation;GO:0051592 response to calcium ion;GO:0014032 neural crest cell development;GO:0048208 COPII vesicle coating;GO:1902527 positive regulation of protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P4Z5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P5E7-1", "uniprot_id": [ { "id": "A0A1D5P5E7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P5E7", "type": "external" } ], "mass": 40003.0, "length": 343, "protein_name": "Poly(ADP-ribose) polymerase family member 11", "gene_name": "PARP11", "organism": "Chicken", "refseq_name": "protein mono-ADP-ribosyltransferase PARP11 isoform X1", "refseq_ac": [ { "id": "XP_416489", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_416489", "type": "external" } ], "gene_names_uniprotkb": "PARP11", "gene_names_refseq": "PARP11", "protein_names_uniprotkb": "Poly(ADP-ribose) polymerase family member 11", "protein_names_refseq": "protein mono-ADP-ribosyltransferase PARP11 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:418264)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_416489.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0016604 nuclear body", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P5E7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P5F4-1", "uniprot_id": [ { "id": "A0A1D5P5F4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P5F4", "type": "external" } ], "mass": 30541.0, "length": 265, "protein_name": "Carbonic anhydrase", "gene_name": "CA3B", "organism": "Chicken", "refseq_name": "carbonic anhydrase 3B", "refseq_ac": [ { "id": "NP_001264339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264339", "type": "external" } ], "gene_names_uniprotkb": "CA3B", "gene_names_refseq": "CA3B; CA3", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1", "protein_names_refseq": "carbonic anhydrase 3B; carbonic anhydrase III-like", "tax_id": 9031, "disease": "", "pathway": " (gga:420209); (R-GGA-1475029)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01025308.1, CR352666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000044.1. On Apr 6, 2013 this sequence version replaced XP_418320.1. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P5F4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P5H5-1", "uniprot_id": [ { "id": "A0A1D5P5H5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P5H5", "type": "external" } ], "mass": 113558.0, "length": 1030, "protein_name": "INO80 complex subunit D", "gene_name": "INO80D", "organism": "Chicken", "refseq_name": "INO80 complex subunit D isoform X1", "refseq_ac": [ { "id": "XP_015145005", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015145005", "type": "external" } ], "gene_names_uniprotkb": "INO80D", "gene_names_refseq": "INO80D", "protein_names_uniprotkb": "INO80 complex subunit D", "protein_names_refseq": "INO80 complex subunit D isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:424103); (R-GGA-5689603); (R-GGA-5696394)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0060382 regulation of DNA strand elongation;GO:0006338 chromatin remodeling;GO:0000723 telomere maintenance;GO:0045893 positive regulation of DNA-templated transcription;GO:0045739 positive regulation of DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P5H5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P5P9-1", "uniprot_id": [ { "id": "A0A1D5P5P9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P5P9", "type": "external" } ], "mass": 78999.0, "length": 709, "protein_name": "Protein-glutamine gamma-glutamyltransferase 4", "gene_name": "TGM4", "organism": "Chicken", "refseq_name": "protein-glutamine gamma-glutamyltransferase 4", "refseq_ac": [ { "id": "NP_001006368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006368", "type": "external" } ], "gene_names_uniprotkb": "TGM4", "gene_names_refseq": "TGM4", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase 4; 2.3.2.13; Transglutaminase-4", "protein_names_refseq": "protein-glutamine gamma-glutamyltransferase 4; transglutaminase 4 (prostate)", "tax_id": 9031, "disease": "", "pathway": " (gga:420706)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720185.1, SRR13267648.26009.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000037.1. On Sep 23, 2021 this sequence version replaced NP_001006368.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.5.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0031012 extracellular matrix", "go_biological_process": "GO:0018149 peptide cross-linking", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P5P9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P5T7-1", "uniprot_id": [ { "id": "A0A1D5P5T7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P5T7", "type": "external" } ], "mass": 61333.0, "length": 541, "protein_name": "Glycerophosphodiester phosphodiesterase domain containing 2", "gene_name": "GDPD2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GDPD2", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycerophosphodiester phosphodiesterase domain containing 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:422217)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0047394 glycerophosphoinositol inositolphosphodiesterase activity;GO:0004629 phospholipase C activity;GO:0008889 glycerophosphodiester phosphodiesterase activity;GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030027 lamellipodium;GO:0016020 membrane", "go_biological_process": "GO:0070446 negative regulation of oligodendrocyte progenitor proliferation;GO:0009306 protein secretion;GO:0006505 GPI anchor metabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P5T7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P624-1", "uniprot_id": [ { "id": "A0A1D5P624_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P624", "type": "external" } ], "mass": 64027.0, "length": 606, "protein_name": "Ubiquilin-4", "gene_name": "UBQLN4", "organism": "Chicken", "refseq_name": "ubiquilin-4", "refseq_ac": [ { "id": "NP_001026544", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026544", "type": "external" } ], "gene_names_uniprotkb": "UBQLN4", "gene_names_refseq": "UBQLN4; ubiquilin-4", "protein_names_uniprotkb": "Ubiquilin-4; Ataxin-1 interacting ubiquitin-like protein; Ataxin-1 ubiquitin-like-interacting protein A1U; Connexin43-interacting protein of 75 kDa", "protein_names_refseq": "ubiquilin-4", "tax_id": 9031, "disease": "", "pathway": " (gga:426353)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267654.116734.1, AJ719666.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000345.1. On Sep 23, 2021 this sequence version replaced NP_001026544.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0031597 cytosolic proteasome complex;GO:0031595 nuclear proteasome complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:1901097 negative regulation of autophagosome maturation;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006281 DNA repair;GO:0006914 autophagy;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P624-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P643-1", "uniprot_id": [ { "id": "A0A1D5P643_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P643", "type": "external" } ], "mass": 23420.0, "length": 203, "protein_name": "Josephin-1", "gene_name": "JOSD1", "organism": "Chicken", "refseq_name": "josephin-1", "refseq_ac": [ { "id": "XP_416259", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_416259", "type": "external" } ], "gene_names_uniprotkb": "JOSD1", "gene_names_refseq": "JOSD1", "protein_names_uniprotkb": "Josephin-1; 3.4.19.12; Josephin domain-containing protein 1; Josephin domain-containing protein 2; Josephin-2", "protein_names_refseq": "josephin-1", "tax_id": 9031, "disease": "", "pathway": " (gga:418023); (R-GGA-5689877)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Cleaves 'Lys-63'-linked poly-ubiquitin chains, and with lesser efficiency 'Lys-48'-linked poly-ubiquitin chains (in vitro). May act as a deubiquitinating enzyme., [UniProtKB, UniProtKB]; Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P643-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P668-1", "uniprot_id": [ { "id": "A0A1D5P668_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P668", "type": "external" } ], "mass": 49492.0, "length": 431, "protein_name": "tRNA nucleotidyl transferase 1", "gene_name": "TRNT1", "organism": "Chicken", "refseq_name": "CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_015148693", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015148693", "type": "external" } ], "gene_names_uniprotkb": "TRNT1", "gene_names_refseq": "TRNT1", "protein_names_uniprotkb": "tRNA nucleotidyl transferase 1", "protein_names_refseq": "CCA tRNA nucleotidyltransferase 1, mitochondrial isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:416103)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052543.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1RY78", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0000049 tRNA binding;GO:0004810 CCA tRNA nucleotidyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0001680 tRNA 3'-terminal CCA addition;GO:1990180 mitochondrial tRNA 3'-end processing;GO:0106354 tRNA surveillance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P668-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P6B6-1", "uniprot_id": [ { "id": "A0A1D5P6B6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P6B6", "type": "external" } ], "mass": 24509.0, "length": 213, "protein_name": "Golgi apparatus membrane protein TVP23 homolog", "gene_name": "TVP23A", "organism": "Chicken", "refseq_name": "Golgi apparatus membrane protein TVP23 homolog A isoform X2", "refseq_ac": [ { "id": "XP_015150063", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015150063", "type": "external" } ], "gene_names_uniprotkb": "TVP23A", "gene_names_refseq": "TVP23A", "protein_names_uniprotkb": "Golgi apparatus membrane protein TVP23 homolog", "protein_names_refseq": "Golgi apparatus membrane protein TVP23 homolog A isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052545.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0009306 protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P6B6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P6C3-1", "uniprot_id": [ { "id": "A0A1D5P6C3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P6C3", "type": "external" } ], "mass": 30146.0, "length": 266, "protein_name": "MOB kinase activator 2", "gene_name": "MOB2", "organism": "Chicken", "refseq_name": "MOB kinase activator 2 isoform X1", "refseq_ac": [ { "id": "XP_421030", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_421030", "type": "external" } ], "gene_names_uniprotkb": "MOB2", "gene_names_refseq": "MOB2", "protein_names_uniprotkb": "MOB kinase activator 2; Mob2 homolog; Mps one binder kinase activator-like 2", "protein_names_refseq": "MOB kinase activator 2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:423097)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Stimulates the autophosphorylation and kinase activity of STK38 and STK38L., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P6C3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P6D2-1", "uniprot_id": [ { "id": "A0A1D5P6D2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P6D2", "type": "external" } ], "mass": 25608.0, "length": 230, "protein_name": "COP9 signalosome complex subunit 8", "gene_name": "COPS8", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COPS8", "gene_names_refseq": "", "protein_names_uniprotkb": "COP9 signalosome complex subunit 8", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-5696394); 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(R-GGA-1222556); (R-GGA-77387); (R-GGA-917977); (R-GGA-9639288)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052539.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. 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This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. 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This record is derived from a genomic sequence (NC_052548.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. 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(gga:100857382); (gga:100857940); (gga:101750273); (gga:107052806); (gga:107052808); (gga:107052809); (gga:107052811); (gga:107052818); (gga:107052820)", "pathway_count": 10, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P6V7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P6X3-1", "uniprot_id": [ { "id": "A0A1D5P6X3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P6X3", "type": "external" } ], "mass": 72754.0, "length": 651, "protein_name": "Ubiquitin-associated and SH3 domain-containing protein B", "gene_name": "UBASH3B", "organism": "Chicken", "refseq_name": "ubiquitin-associated and SH3 domain-containing protein B", "refseq_ac": [ { "id": "XP_015153661", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015153661", "type": "external" } ], "gene_names_uniprotkb": "UBASH3B", "gene_names_refseq": "UBASH3B", "protein_names_uniprotkb": "Ubiquitin-associated and SH3 domain-containing protein B; 3.1.3.48; Cbl-interacting protein p70; Suppressor of T-cell receptor signaling 1; T-cell ubiquitin ligand 2; Tyrosine-protein phosphatase STS1/TULA2", "protein_names_refseq": "ubiquitin-associated and SH3 domain-containing protein B", "tax_id": 9031, "disease": "", "pathway": " (gga:419748)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052555.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity;GO:0042802 identical protein binding;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0070527 platelet aggregation;GO:0009968 negative regulation of signal transduction;GO:0051279 regulation of release of sequestered calcium ion into cytosol;GO:0045779 negative regulation of bone resorption;GO:0045670 regulation of osteoclast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P6X3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P737-1", "uniprot_id": [ { "id": "A0A1D5P737_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P737", "type": "external" } ], "mass": 48539.0, "length": 446, "protein_name": "G protein-coupled receptor 61", "gene_name": "GPR61", "organism": "Chicken", "refseq_name": "G-protein coupled receptor 61", "refseq_ac": [ { "id": "XP_046760159", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046760159", "type": "external" } ], "gene_names_uniprotkb": "GPR61", "gene_names_refseq": "GPR61", "protein_names_uniprotkb": "G protein-coupled receptor 61", "protein_names_refseq": "G-protein coupled receptor 61", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052557.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:1990763 arrestin family protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0038035 ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P737-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P759-1", "uniprot_id": [ { "id": "A0A1D5P759_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P759", "type": "external" } ], "mass": 233241.0, "length": 2077, "protein_name": "Autophagy related 2A", "gene_name": "ATG2A", "organism": "Chicken", "refseq_name": "autophagy-related protein 2 homolog B isoform X1", "refseq_ac": [ { "id": "XP_040557985", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040557985", "type": "external" } ], "gene_names_uniprotkb": "ATG2A", "gene_names_refseq": "ATG2A", "protein_names_uniprotkb": "Autophagy related 2A", "protein_names_refseq": "autophagy-related protein 2 homolog B isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043495 protein-membrane adaptor activity;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0120013 lipid transfer activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site;GO:0061908 phagophore", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0000422 autophagy of mitochondrion;GO:0034727 piecemeal microautophagy of the nucleus;GO:0061709 reticulophagy;GO:0061723 glycophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P759-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P765-1", "uniprot_id": [ { "id": "A0A1D5P765_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P765", "type": "external" } ], "mass": 42501.0, "length": 390, "protein_name": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial", "gene_name": "BCKDHB", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "BCKDHB", "gene_names_refseq": "", "protein_names_uniprotkb": "2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; 1.2.4.4; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-70895); (R-GGA-9859138)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Together with BCKDHA forms the heterotetrameric E1 subunit of the mitochondrial branched-chain alpha-ketoacid dehydrogenase (BCKD) complex. The BCKD complex catalyzes the multi-step oxidative decarboxylation of alpha-ketoacids derived from the branched-chain amino-acids valine, leucine and isoleucine producing CO2 and acyl-CoA which is subsequently utilized to produce energy. The E1 subunit catalyzes the first step with the decarboxylation of the alpha-ketoacid forming an enzyme-product intermediate. A reductive acylation mediated by the lipoylamide cofactor of E2 extracts the acyl group from the E1 active site for the next step of the reaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.4", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0003863 branched-chain 2-oxo acid dehydrogenase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0160157 branched-chain alpha-ketoacid dehydrogenase complex", "go_biological_process": "GO:0007584 response to nutrient;GO:0009083 branched-chain amino acid catabolic process;GO:0120552 branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P765-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P774-1", "uniprot_id": [ { "id": "A0A1D5P774_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P774", "type": "external" } ], "mass": 145652.0, "length": 1318, "protein_name": "Tripeptidyl-peptidase 2", "gene_name": "TPP2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TPP2", "gene_names_refseq": "", "protein_names_uniprotkb": "Tripeptidyl-peptidase 2; 3.4.14.10; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase II", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-983168)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytosolic tripeptidyl-peptidase that releases N-terminal tripeptides from polypeptides and is a component of the proteolytic cascade acting downstream of the 26S proteasome in the ubiquitin-proteasome pathway. It plays an important role in intracellular amino acid homeostasis. Stimulates adipogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.14.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.10", "type": "external" }, { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" }, { "id": "3.4.22.40", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.40", "type": "external" }, { "id": "3.4.11.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.3", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008240 tripeptidyl-peptidase activity;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016604 nuclear body;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P774-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P781-1", "uniprot_id": [ { "id": "A0A1D5P781_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P781", "type": "external" } ], "mass": 73723.0, "length": 665, "protein_name": "Zinc finger and BTB domain containing 32", "gene_name": "ZBTB32", "organism": "Chicken", "refseq_name": "zinc finger and BTB domain-containing protein 16", "refseq_ac": [ { "id": "NP_001308417", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308417", "type": "external" } ], "gene_names_uniprotkb": "ZBTB32", "gene_names_refseq": "ZBTB16; ZBTB32; ZGC:55675", "protein_names_uniprotkb": "Zinc finger and BTB domain containing 32", "protein_names_refseq": "zinc finger and BTB domain containing 16; zinc finger and BTB domain-containing protein 16; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia)", "tax_id": 9031, "disease": "", "pathway": " (gga:419759)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888538.311467.1, SRR13267653.23287.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN04013384, SAMN06140855 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000341.1. On Mar 25, 2016 this sequence version replaced XP_015153699.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0017053 transcription repressor complex;GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045600 positive regulation of fat cell differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P781-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P7B5-1", "uniprot_id": [ { "id": "A0A1D5P7B5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P7B5", "type": "external" } ], "mass": 38616.0, "length": 348, "protein_name": "Large ribosomal subunit protein uL3m", "gene_name": "MRPL3", "organism": "Chicken", "refseq_name": "large ribosomal subunit protein uL3m", "refseq_ac": [ { "id": "NP_001006366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006366", "type": "external" } ], "gene_names_uniprotkb": "MRPL3", "gene_names_refseq": "MRPL3", "protein_names_uniprotkb": "Large ribosomal subunit protein uL3m; 39S ribosomal protein L3, mitochondrial", "protein_names_refseq": "39S ribosomal protein L3, mitochondrial; large ribosomal subunit protein uL3m", "tax_id": 9031, "disease": "", "pathway": " (gga:420686); (R-GGA-5389840); (R-GGA-5419276); (R-GGA-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719688.1, HAEL01001219.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000037.1. On Sep 23, 2021 this sequence version replaced NP_001006366.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P7B5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P7J2-1", "uniprot_id": [ { "id": "A0A1D5P7J2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P7J2", "type": "external" } ], "mass": 71011.0, "length": 636, "protein_name": "Epithelial splicing regulatory protein 1", "gene_name": "ESRP1", "organism": "Chicken", "refseq_name": "epithelial splicing regulatory protein 1 isoform X1", "refseq_ac": [ { "id": "XP_418338", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_418338", "type": "external" } ], "gene_names_uniprotkb": "ESRP1", "gene_names_refseq": "ESRP1", "protein_names_uniprotkb": "Epithelial splicing regulatory protein 1", "protein_names_refseq": "epithelial splicing regulatory protein 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_418338.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:1990904 ribonucleoprotein complex;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P7J2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P7L9-1", "uniprot_id": [ { "id": "A0A1D5P7L9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P7L9", "type": "external" } ], "mass": 27776.0, "length": 249, "protein_name": "Pleckstrin homology domain-containing family F member 2", "gene_name": "PLEKHF2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PLEKHF2", "gene_names_refseq": "", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family F member 2", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:420234)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0031901 early endosome membrane;GO:0030133 transport vesicle", "go_biological_process": "GO:0015031 protein transport;GO:0007032 endosome organization;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P7L9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P7R6-1", "uniprot_id": [ { "id": "A0A1D5P7R6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P7R6", "type": "external" } ], "mass": 40193.0, "length": 361, "protein_name": "Thromboxane A2 receptor", "gene_name": "TBXA2R", "organism": "Chicken", "refseq_name": "thromboxane A2 receptor", "refseq_ac": [ { "id": "XP_015155258", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015155258", "type": "external" } ], "gene_names_uniprotkb": "TBXA2R", "gene_names_refseq": "TBXA2R", "protein_names_uniprotkb": "Thromboxane A2 receptor; Prostanoid TP receptor", "protein_names_refseq": "thromboxane A2 receptor", "tax_id": 9031, "disease": "", "pathway": " (gga:100857635); (R-GGA-391908); (R-GGA-416476); (R-GGA-416482); (R-GGA-428930)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052559.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PRP2", "ec_number_list": [], "go_molecular_function": "GO:0004961 thromboxane A2 receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis;GO:0006954 inflammatory response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0045777 positive regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P7R6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P7S6-1", "uniprot_id": [ { "id": "A0A1D5P7S6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P7S6", "type": "external" } ], "mass": 79050.0, "length": 709, "protein_name": "Relaxin family peptide receptor 2", "gene_name": "RXFP2", "organism": "Chicken", "refseq_name": "relaxin receptor 1", "refseq_ac": [ { "id": "XP_015133815", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015133815", "type": "external" } ], "gene_names_uniprotkb": "RXFP2", "gene_names_refseq": "RXFP2", "protein_names_uniprotkb": "Relaxin family peptide receptor 2", "protein_names_refseq": "relaxin receptor 1", "tax_id": 9031, "disease": "", "pathway": " (gga:428695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008528 G protein-coupled peptide receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0009755 hormone-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P7S6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P7U7-1", "uniprot_id": [ { "id": "A0A1D5P7U7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P7U7", "type": "external" } ], "mass": 10094.0, "length": 86, "protein_name": "Splicing factor 3B subunit 5", "gene_name": "SF3B5", "organism": "Chicken", "refseq_name": "splicing factor 3B subunit 5", "refseq_ac": [ { "id": "NP_001289019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289019", "type": "external" } ], "gene_names_uniprotkb": "SF3B5", "gene_names_refseq": "SF3B5", "protein_names_uniprotkb": "Splicing factor 3B subunit 5; SF3b5", "protein_names_refseq": "splicing factor 3B subunit 5; splicing factor 3b, subunit 5, 10kDa", "tax_id": 9031, "disease": "", "pathway": " (gga:769794); (R-GGA-72165); (R-GGA-9770562)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript is intronless :: HAEK01124257.1, HAEL01008669.1 [ECO:0000345] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000063.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:1990935 splicing factor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005686 U2 snRNP;GO:0071011 precatalytic spliceosome;GO:0005689 U12-type spliceosomal complex;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P7U7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P7Z5-1", "uniprot_id": [ { "id": "A0A1D5P7Z5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P7Z5", "type": "external" } ], "mass": 37272.0, "length": 340, "protein_name": "G protein subunit beta 3", "gene_name": "GNB3", "organism": "Chicken", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3", "refseq_ac": [ { "id": "NP_001376416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376416", "type": "external" } ], "gene_names_uniprotkb": "GNB3", "gene_names_refseq": "GNB3", "protein_names_uniprotkb": "G protein subunit beta 3", "protein_names_refseq": "guanine nucleotide binding protein (G protein), beta polypeptide 3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1296041); (R-GGA-202040); (R-GGA-392170); (R-GGA-392451); (R-GGA-4086398); (R-GGA-416476); (R-GGA-416482); (R-GGA-418217); (R-GGA-418555); (R-GGA-418592); (R-GGA-418594); (R-GGA-418597); (R-GGA-428930); (R-GGA-456926); (R-GGA-500657); (R-GGA-6814122); (R-GGA-8964315); (R-GGA-8964616); (R-GGA-9009391); (R-GGA-9634597); (R-GGA-9717207); (R-GGA-997272)", "pathway_count": 22, "publication_count": 1, "publication_id_list": "21887213", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267657.21597.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000015.1., [RefSeq]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB, UniProtKB]; These findings confirm that the D153del mutation in GNB3 gene targets GNB3 protein to early degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051020 GTPase binding;GO:0030159 signaling receptor complex adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0090181 regulation of cholesterol metabolic process;GO:0010906 regulation of glucose metabolic process;GO:0006884 cell volume homeostasis;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5P7Z5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P801-1", "uniprot_id": [ { "id": "A0A1D5P801_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P801", "type": "external" } ], "mass": 101300.0, "length": 882, "protein_name": "dipeptidyl-peptidase IV", "gene_name": "DPP8", "organism": "Chicken", "refseq_name": "dipeptidyl peptidase 8 isoform X1", "refseq_ac": [ { "id": "XP_004943953", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004943953", "type": "external" } ], "gene_names_uniprotkb": "DPP8", "gene_names_refseq": "DPP8", "protein_names_uniprotkb": "dipeptidyl-peptidase IV; 3.4.14.5", "protein_names_refseq": "dipeptidyl peptidase 8 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:427512)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052541.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0004177 aminopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0043069 negative regulation of programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P801-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P8A9-1", "uniprot_id": [ { "id": "A0A1D5P8A9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P8A9", "type": "external" } ], "mass": 84670.0, "length": 765, "protein_name": "SNF-related serine/threonine-protein kinase", "gene_name": "SNRK", "organism": "Chicken", "refseq_name": "SNF-related serine/threonine-protein kinase", "refseq_ac": [ { "id": "NP_001186631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186631", "type": "external" } ], "gene_names_uniprotkb": "SNRK", "gene_names_refseq": "SNRK", "protein_names_uniprotkb": "SNF-related serine/threonine-protein kinase; 2.7.11.1; SNF1-related kinase", "protein_names_refseq": "SNF-related serine/threonine-protein kinase", "tax_id": 9031, "disease": "", "pathway": " (gga:420675)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: ERR2365563.110832.1, SRR13267655.257601.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992470 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000037.1. On Dec 12, 2010 this sequence version replaced XP_418774.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; May play a role in hematopoietic cell proliferation or differentiation. Potential mediator of neuronal apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P8A9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P8I3-1", "uniprot_id": [ { "id": "A0A1D5P8I3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P8I3", "type": "external" } ], "mass": 69532.0, "length": 647, "protein_name": "Splicing factor proline and glutamine rich", "gene_name": "SFPQ", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SFPQ", "gene_names_refseq": "", "protein_names_uniprotkb": "Splicing factor proline and glutamine rich", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395803)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0030425 dendrite;GO:0016363 nuclear matrix;GO:0000785 chromatin", "go_biological_process": "GO:0098963 dendritic transport of messenger ribonucleoprotein complex;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P8I3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P8K0-1", "uniprot_id": [ { "id": "A0A1D5P8K0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P8K0", "type": "external" } ], "mass": 45180.0, "length": 417, "protein_name": "Runt-related transcription factor", "gene_name": "RUNX3", "organism": "Chicken", "refseq_name": "runt-related transcription factor 3", "refseq_ac": [ { "id": "XP_015153219", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015153219", "type": "external" } ], "gene_names_uniprotkb": "RUNX3", "gene_names_refseq": "RUNX3", "protein_names_uniprotkb": "Runt-related transcription factor", "protein_names_refseq": "runt-related transcription factor 3", "tax_id": 9031, "disease": "", "pathway": " (gga:769687); (R-GGA-8941855); (R-GGA-8941856); (R-GGA-8941858); (R-GGA-8951430); (R-GGA-8951671); (R-GGA-8951936)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052554.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Apr 10, 2021 this sequence version replaced XP_015153219.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001222 transcription corepressor binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005634 nucleus", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P8K0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P8P3-1", "uniprot_id": [ { "id": "A0A1D5P8P3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P8P3", "type": "external" } ], "mass": 160770.0, "length": 1669, "protein_name": "Collagen type IV alpha 1 chain", "gene_name": "COL4A1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COL4A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Collagen type IV alpha 1 chain", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395530); (R-GGA-1442490); (R-GGA-1566977); (R-GGA-1650814); (R-GGA-186797); (R-GGA-2022090); (R-GGA-216083); (R-GGA-2243919); (R-GGA-3000171)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 0, "predicted_o_glycosites": 11, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030020 extracellular matrix structural constituent conferring tensile strength;GO:0048407 platelet-derived growth factor binding;GO:0005201 extracellular matrix structural constituent", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005587 collagen type IV trimer;GO:0005604 basement membrane;GO:0005581 collagen trimer", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0007420 brain development;GO:0001569 branching involved in blood vessel morphogenesis;GO:0061304 retinal blood vessel morphogenesis;GO:0061333 renal tubule morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P8P3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P8P8-1", "uniprot_id": [ { "id": "A0A1D5P8P8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P8P8", "type": "external" } ], "mass": 34671.0, "length": 337, "protein_name": "NK2 homeobox 4", "gene_name": "NKX2-4", "organism": "Chicken", "refseq_name": "homeobox protein Nkx-2.4", "refseq_ac": [ { "id": "XP_015138916", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015138916", "type": "external" } ], "gene_names_uniprotkb": "NKX2-4", "gene_names_refseq": "NKX2-4", "protein_names_uniprotkb": "NK2 homeobox 4", "protein_names_refseq": "homeobox protein Nkx-2.4", "tax_id": 9031, "disease": "", "pathway": " (gga:107052856)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P8P8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P8S9-1", "uniprot_id": [ { "id": "A0A1D5P8S9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P8S9", "type": "external" } ], "mass": 121169.0, "length": 1121, "protein_name": "Nuclear factor of activated T cells 3", "gene_name": "NFATC3", "organism": "Chicken", "refseq_name": "nuclear factor of activated T-cells, cytoplasmic 3 isoform X1", "refseq_ac": [ { "id": "XP_015147848", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015147848", "type": "external" } ], "gene_names_uniprotkb": "NFATC3", "gene_names_refseq": "NFATC3", "protein_names_uniprotkb": "Nuclear factor of activated T cells 3", "protein_names_refseq": "nuclear factor of activated T-cells, cytoplasmic 3 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:415711); (R-GGA-2871809); (R-GGA-5607763)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:0005737 cytoplasm", "go_biological_process": "GO:1905064 negative regulation of vascular associated smooth muscle cell differentiation;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0033173 calcineurin-NFAT signaling cascade;GO:1902894 negative regulation of miRNA transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P8S9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P8W2-1", "uniprot_id": [ { "id": "A0A1D5P8W2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P8W2", "type": "external" } ], "mass": 28679.0, "length": 261, "protein_name": "Mediator of RNA polymerase II transcription subunit 4", "gene_name": "MED4", "organism": "Chicken", "refseq_name": "mediator of RNA polymerase II transcription subunit 4", "refseq_ac": [ { "id": "XP_004938759", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004938759", "type": "external" } ], "gene_names_uniprotkb": "MED4", "gene_names_refseq": "MED4", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 4; Mediator complex subunit 4", "protein_names_refseq": "mediator of RNA polymerase II transcription subunit 4", "tax_id": 9031, "disease": "", "pathway": " (gga:418859); (R-GGA-9841922)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046966 nuclear thyroid hormone receptor binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P8W2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P8Y9-1", "uniprot_id": [ { "id": "A0A1D5P8Y9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P8Y9", "type": "external" } ], "mass": 36982.0, "length": 325, "protein_name": "Melanocortin receptor 5", "gene_name": "MC5R", "organism": "Chicken", "refseq_name": "melanocortin receptor 5 isoform a", "refseq_ac": [ { "id": "NP_001026186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026186", "type": "external" } ], "gene_names_uniprotkb": "MC5R", "gene_names_refseq": "MC5R", "protein_names_uniprotkb": "Melanocortin receptor 5", "protein_names_refseq": "melanocortin receptor 5 isoform a; melanocortin receptor 5", "tax_id": 9031, "disease": "", "pathway": " (gga:421047); (R-GGA-375276); (R-GGA-418555)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "31356812", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.128807.1, SRR13267658.25361.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000042.1. On Dec 14, 2021 this sequence version replaced NP_001026186.1., [RefSeq]; These findings demonstrated that presence of interspecies differences for MC5Rs, particularly for the pERK1/2 pathway., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004977 melanocortin receptor activity;GO:0004978 corticotropin receptor activity;GO:0004980 melanocyte-stimulating hormone receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0001659 temperature homeostasis;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0050777 negative regulation of immune response;GO:0045921 positive regulation of exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5P8Y9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P910-1", "uniprot_id": [ { "id": "A0A1D5P910_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P910", "type": "external" } ], "mass": 34743.0, "length": 311, "protein_name": "CUE domain containing 2", "gene_name": "CUEDC2", "organism": "Chicken", "refseq_name": "CUE domain-containing protein 2 isoform 1", "refseq_ac": [ { "id": "NP_001264278", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264278", "type": "external" } ], "gene_names_uniprotkb": "CUEDC2", "gene_names_refseq": "CUEDC2", "protein_names_uniprotkb": "CUE domain containing 2", "protein_names_refseq": "CUE domain-containing protein 2 isoform 1", "tax_id": 9031, "disease": "", "pathway": " (gga:423761)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX935832.2 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DN930132.1, BX935832.2 and BU296957.1. On or before Apr 4, 2013 this sequence version replaced XP_421635.3, XP_003641540.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P910-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P9A5-1", "uniprot_id": [ { "id": "A0A1D5P9A5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P9A5", "type": "external" } ], "mass": 62831.0, "length": 582, "protein_name": "Cleavage and polyadenylation specificity factor subunit 6", "gene_name": "CPSF6", "organism": "Chicken", "refseq_name": "cleavage and polyadenylation specificity factor subunit 6 isoform X2", "refseq_ac": [ { "id": "XP_015137219", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015137219", "type": "external" } ], "gene_names_uniprotkb": "CPSF6", "gene_names_refseq": "CPSF6", "protein_names_uniprotkb": "Cleavage and polyadenylation specificity factor subunit 6", "protein_names_refseq": "cleavage and polyadenylation specificity factor subunit 6 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:417844); (R-GGA-9770562)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0110104 mRNA alternative polyadenylation;GO:0006397 mRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P9A5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PMG2-1", "uniprot_id": [ { "id": "A0A1D5PMG2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PMG2", "type": "external" } ], "mass": 84689.0, "length": 778, "protein_name": "Serine/threonine-protein kinase DCLK2", "gene_name": "DCLK2", "organism": "Chicken", "refseq_name": "serine/threonine-protein kinase DCLK2 isoform X1", "refseq_ac": [ { "id": "XP_003641209", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003641209", "type": "external" } ], "gene_names_uniprotkb": "DCLK2", "gene_names_refseq": "DCLK2", "protein_names_uniprotkb": "Serine/threonine-protein kinase DCLK2; 2.7.11.1; CaMK-like CREB regulatory kinase 2; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2", "protein_names_refseq": "serine/threonine-protein kinase DCLK2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:422473)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007417 central nervous system development;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PMG2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P9V5-1", "uniprot_id": [ { "id": "A0A1D5P9V5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P9V5", "type": "external" } ], "mass": 125240.0, "length": 1125, "protein_name": "Solute carrier family 12 member 7", "gene_name": "SLC12A7", "organism": "Chicken", "refseq_name": "solute carrier family 12 member 7", "refseq_ac": [ { "id": "NP_001006371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006371", "type": "external" } ], "gene_names_uniprotkb": "SLC12A7", "gene_names_refseq": "SLC12A7", "protein_names_uniprotkb": "Solute carrier family 12 member 7", "protein_names_refseq": "solute carrier family 12 (potassium/chloride transporter), member 7; solute carrier family 12 (potassium/chloride transporters), member 7; solute carrier family 12 member 7", "tax_id": 9031, "disease": "", "pathway": " (gga:420797); (R-GGA-426117)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992482 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000039.1. On Oct 5, 2007 this sequence version replaced NP_001006371.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0015379 potassium:chloride symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0032991 protein-containing complex;GO:0016020 membrane", "go_biological_process": "GO:0071333 cellular response to glucose stimulus;GO:0007268 chemical synaptic transmission;GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P9V5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P9X0-1", "uniprot_id": [ { "id": "A0A1D5P9X0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P9X0", "type": "external" } ], "mass": 36873.0, "length": 334, "protein_name": "Ephrin-B1", "gene_name": "EFNB1", "organism": "Chicken", "refseq_name": "ephrin-B1 precursor", "refseq_ac": [ { "id": "NP_990366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990366", "type": "external" } ], "gene_names_uniprotkb": "EFNB1", "gene_names_refseq": "EFNB1", "protein_names_uniprotkb": "Ephrin-B1", "protein_names_refseq": "CEK5 ligand; CEK5-L; ephrin-B1 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:395896); (R-GGA-2682334); (R-GGA-3928662); (R-GGA-3928664); (R-GGA-3928665)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "17108003;19918883;23319347;23916864", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U72394.1, SRR13267649.119860.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000071.1. On Sep 23, 2021 this sequence version replaced NP_990366.1., [RefSeq]; Early role for ephrinB ligands for migration of epicardial cells and a later role in perivascular fibroblasts of coronary vessels in the atrioventricular sulcus, [RefSeq, PubMed]; In Japanese Silky embryos, ventral areas, including the anterior- and posterior-half somites, expressed ephrin-B1 in a pattern that correlates with the atypical migratory pathways taken by Japanese Silky melanoblasts., [RefSeq, PubMed]; The results demonstrate that local inhibitory interactions within inter-ganglionic regions, mediated by Eph/ephrins, and adhesive cell-cell contacts at ganglia sites, mediated by N-cadherin, coordinate to sculpt discrete sympathetic ganglia., [RefSeq, PubMed]; We propose that interaction between ephrin-B1 and its receptor is involved in boundary stabilization during feather morphogenesis., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046875 ephrin receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0042734 presynaptic membrane;GO:0016020 membrane", "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0007411 axon guidance;GO:0007399 nervous system development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A1D5P9X0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5P9Z7-1", "uniprot_id": [ { "id": "A0A1D5P9Z7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5P9Z7", "type": "external" } ], "mass": 44096.0, "length": 391, "protein_name": "Gap junction protein", "gene_name": "LOC107049146", "organism": "Chicken", "refseq_name": "gap junction gamma-1 protein-like", "refseq_ac": [ { "id": "XP_015145193", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015145193", "type": "external" } ], "gene_names_uniprotkb": "LOC107049146", "gene_names_refseq": "LOC107049146", "protein_names_uniprotkb": "Gap junction protein", "protein_names_refseq": "gap junction gamma-1 protein-like", "tax_id": 9031, "disease": "", "pathway": " (gga:107049146)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007154 cell communication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5P9Z7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PA08-1", "uniprot_id": [ { "id": "A0A1D5PA08_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PA08", "type": "external" } ], "mass": 56111.0, "length": 490, "protein_name": "Serine/threonine-protein kinase 3", "gene_name": "STK3", "organism": "Chicken", "refseq_name": "serine/threonine-protein kinase 3", "refseq_ac": [ { "id": "NP_001026508", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026508", "type": "external" } ], "gene_names_uniprotkb": "STK3", "gene_names_refseq": "STK3", "protein_names_uniprotkb": "Serine/threonine-protein kinase 3; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase 3", "tax_id": 9031, "disease": "", "pathway": " (gga:425375); (R-GGA-2028269)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851727.1, SRR13267654.138589.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000044.1. On Sep 23, 2021 this sequence version replaced NP_001026508.2., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0000287 magnesium ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0007165 signal transduction;GO:0051262 protein tetramerization;GO:0006915 apoptotic process;GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PA08-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PA22-1", "uniprot_id": [ { "id": "A0A1D5PA22_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PA22", "type": "external" } ], "mass": 28639.0, "length": 249, "protein_name": "Phosducin", "gene_name": "PDC", "organism": "Chicken", "refseq_name": "phosducin", "refseq_ac": [ { "id": "XP_004943360", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004943360", "type": "external" } ], "gene_names_uniprotkb": "PDC", "gene_names_refseq": "PDC", "protein_names_uniprotkb": "Phosducin", "protein_names_refseq": "phosducin", "tax_id": 9031, "disease": "", "pathway": " (gga:429078)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052539.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007601 visual perception;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PA22-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PA28-1", "uniprot_id": [ { "id": "A0A1D5PA28_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PA28", "type": "external" } ], "mass": 27919.0, "length": 246, "protein_name": "Thiol methyltransferase 1A", "gene_name": "METTL7A", "organism": "Chicken", "refseq_name": "methyltransferase-like protein 7A", "refseq_ac": [ { "id": "XP_424479", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_424479", "type": "external" } ], "gene_names_uniprotkb": "METTL7A", "gene_names_refseq": "METTL7A", "protein_names_uniprotkb": "Thiol methyltransferase 1A", "protein_names_refseq": "methyltransferase-like protein 7A", "tax_id": 9031, "disease": "", "pathway": " (gga:426871)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052565.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_424479.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0008168 methyltransferase activity;GO:0018708 thiol S-methyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005811 lipid droplet", "go_biological_process": "GO:0001649 osteoblast differentiation;GO:0180035 lncRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PA28-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PAD6-1", "uniprot_id": [ { "id": "A0A1D5PAD6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PAD6", "type": "external" } ], "mass": 17708.0, "length": 152, "protein_name": "ALK and LTK ligand 2", "gene_name": "FAM150B", "organism": "Chicken", "refseq_name": "ALK and LTK ligand 2", "refseq_ac": [ { "id": "XP_015140420", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015140420", "type": "external" } ], "gene_names_uniprotkb": "FAM150B", "gene_names_refseq": "FAM150B", "protein_names_uniprotkb": "ALK and LTK ligand 2", "protein_names_refseq": "ALK and LTK ligand 2", "tax_id": 9031, "disease": "", "pathway": " (gga:421910); (R-GGA-201556); (R-GGA-9842663)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0030971 receptor tyrosine kinase binding;GO:0030298 receptor signaling protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0010976 positive regulation of neuron projection development;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0070378 positive regulation of ERK5 cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PAD6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PAM4-1", "uniprot_id": [ { "id": "A0A1D5PAM4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PAM4", "type": "external" } ], "mass": 8559.0, "length": 77, "protein_name": "Heat shock factor-binding protein 1", "gene_name": "HSBP1", "organism": "Chicken", "refseq_name": "heat shock factor-binding protein 1", "refseq_ac": [ { "id": "NP_001106280", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106280", "type": "external" } ], "gene_names_uniprotkb": "HSBP1", "gene_names_refseq": "HSBP1", "protein_names_uniprotkb": "Heat shock factor-binding protein 1", "protein_names_refseq": "heat shock factor-binding protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:415813); (R-GGA-3371568); (R-GGA-3371571)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01005768.1, HAEK01105972.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMN02738227 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000248.1. On Dec 28, 2007 this sequence version replaced XP_414175.2., [RefSeq]; Negative regulator of the heat shock response. Negatively affects HSF1 DNA-binding activity. May have a role in the suppression of the activation of the stress response during the aging process., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:1904115 axon cytoplasm", "go_biological_process": "GO:0019896 axonal transport of mitochondrion;GO:0070370 cellular heat acclimation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PAM4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PAN7-1", "uniprot_id": [ { "id": "A0A1D5PAN7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PAN7", "type": "external" } ], "mass": 12327.0, "length": 121, "protein_name": "Keratin", "gene_name": "LOC121112086", "organism": "Chicken", "refseq_name": "scale keratin-like", "refseq_ac": [ { "id": "XP_040546993", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040546993", "type": "external" } ], "gene_names_uniprotkb": "LOC121112086", "gene_names_refseq": "LOC121112086", "protein_names_uniprotkb": "Keratin", "protein_names_refseq": "scale keratin-like", "tax_id": 9031, "disease": "", "pathway": " (gga:100859586); (gga:100859657); (gga:425362); (gga:431316)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052597.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PAN7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PB73-1", "uniprot_id": [ { "id": "A0A1D5PB73_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PB73", "type": "external" } ], "mass": 105141.0, "length": 926, "protein_name": "Peripheral plasma membrane protein CASK", "gene_name": "CASK", "organism": "Chicken", "refseq_name": "peripheral plasma membrane protein CASK isoform X1", "refseq_ac": [ { "id": "XP_015157135", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015157135", "type": "external" } ], "gene_names_uniprotkb": "CASK", "gene_names_refseq": "CASK", "protein_names_uniprotkb": "Peripheral plasma membrane protein CASK; 2.7.11.1; Calcium/calmodulin-dependent serine protein kinase", "protein_names_refseq": "peripheral plasma membrane protein CASK isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-212676); (R-GGA-6794361)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005102 signaling receptor binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004672 protein kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0001953 negative regulation of cell-matrix adhesion;GO:0046928 regulation of neurotransmitter secretion;GO:0061045 negative regulation of wound healing;GO:0010839 negative regulation of keratinocyte proliferation;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PB73-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PBF9-1", "uniprot_id": [ { "id": "A0A1D5PBF9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PBF9", "type": "external" } ], "mass": 37909.0, "length": 373, "protein_name": "SRY-box 1", "gene_name": "SOX1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SOX1", "gene_names_refseq": "", "protein_names_uniprotkb": "SRY-box 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PBF9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PBH8-1", "uniprot_id": [ { "id": "A0A1D5PBH8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PBH8", "type": "external" } ], "mass": 57438.0, "length": 498, "protein_name": "Angiopoietin-1", "gene_name": "ANGPT1", "organism": "Chicken", "refseq_name": "angiopoietin-1 precursor", "refseq_ac": [ { "id": "NP_001186376", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186376", "type": "external" } ], "gene_names_uniprotkb": "ANGPT1", "gene_names_refseq": "ANG-1; ANGPT1", "protein_names_uniprotkb": "Angiopoietin-1", "protein_names_refseq": "Angiopoietin-1; angiopoietin-1 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:395129); (R-GGA-210993); (R-GGA-5673001)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15019822", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.45399.1, ERR2286007.110212.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03579564 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000044.1. On Dec 7, 2010 this sequence version replaced XP_418382.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; The ratio of ANGPT2/ANGPT1 mRNA in endometrial grafts increased after 24 hours of cultivation on the chicken chorioallantoic membrane and shows a shift toward a more dominant role of ANGPT2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0030971 receptor tyrosine kinase binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0045121 membrane raft", "go_biological_process": "GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0043066 negative regulation of apoptotic process;GO:0007596 blood coagulation;GO:0007162 negative regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5PBH8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PBN7-1", "uniprot_id": [ { "id": "A0A1D5PBN7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PBN7", "type": "external" } ], "mass": 33587.0, "length": 297, "protein_name": "Large ribosomal subunit protein uL15m", "gene_name": "MRPL15", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MRPL15", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein uL15m; 39S ribosomal protein L15, mitochondrial", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:421121); (R-GGA-5389840); (R-GGA-5419276); (R-GGA-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PBN7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PC23-1", "uniprot_id": [ { "id": "A0A1D5PC23_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PC23", "type": "external" } ], "mass": 37582.0, "length": 337, "protein_name": "Transaldolase", "gene_name": "TALDO1", "organism": "Chicken", "refseq_name": "transaldolase", "refseq_ac": [ { "id": "NP_001026348", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026348", "type": "external" } ], "gene_names_uniprotkb": "TALDO1", "gene_names_refseq": "TALDO1; transaldolase", "protein_names_uniprotkb": "Transaldolase; 2.2.1.2", "protein_names_refseq": "transaldolase", "tax_id": 9031, "disease": "", "pathway": " (gga:423019); (R-GGA-163754); (R-GGA-71336)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01119299.1, HAEK01118511.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992531, SAMN06143077 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000212.1. On Sep 23, 2021 this sequence version replaced NP_001026348.1., [RefSeq]; Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.2.1.2", "type": "external" } ], "go_molecular_function": "GO:0004801 transaldolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0009052 pentose-phosphate shunt, non-oxidative branch;GO:0005975 carbohydrate metabolic process;GO:0006098 pentose-phosphate shunt", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PC23-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PC35-1", "uniprot_id": [ { "id": "A0A1D5PC35_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PC35", "type": "external" } ], "mass": 11285.0, "length": 102, "protein_name": "LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated", "gene_name": "LSM3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LSM3", "gene_names_refseq": "", "protein_names_uniprotkb": "LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-430039)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0000932 P-body;GO:0071013 catalytic step 2 spliceosome;GO:0071011 precatalytic spliceosome;GO:0046540 U4/U6 x U5 tri-snRNP complex;GO:0005688 U6 snRNP", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0033962 P-body assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PC35-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PC44-1", "uniprot_id": [ { "id": "A0A1D5PC44_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PC44", "type": "external" } ], "mass": 51685.0, "length": 443, "protein_name": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B", "gene_name": "PPP2R2B", "organism": "Chicken", "refseq_name": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3", "refseq_ac": [ { "id": "XP_015149540", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015149540", "type": "external" } ], "gene_names_uniprotkb": "PPP2R2B", "gene_names_refseq": "PPP2R2B", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B", "protein_names_refseq": "serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:416350)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019888 protein phosphatase regulator activity", "go_cellular_component": "GO:0000159 protein phosphatase type 2A complex;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PC44-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PC97-1", "uniprot_id": [ { "id": "A0A1D5PC97_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PC97", "type": "external" } ], "mass": 22865.0, "length": 219, "protein_name": "Steroid receptor RNA activator 1", "gene_name": "SRA1", "organism": "Chicken", "refseq_name": "steroid receptor RNA activator 1", "refseq_ac": [ { "id": "NP_001288615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288615", "type": "external" } ], "gene_names_uniprotkb": "SRA1", "gene_names_refseq": "SRA1", "protein_names_uniprotkb": "Steroid receptor RNA activator 1; Steroid receptor RNA activator protein", "protein_names_refseq": "steroid receptor RNA activator 1", "tax_id": 9031, "disease": "", "pathway": " (gga:427608)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CR338992.2, CR338823.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000254.1., [RefSeq]; Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002153 steroid receptor RNA activator RNA binding;GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:0045662 negative regulation of myoblast differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PC97-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PD64-1", "uniprot_id": [ { "id": "A0A1D5PD64_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PD64", "type": "external" } ], "mass": 39422.0, "length": 346, "protein_name": "mitogen-activated protein kinase kinase", "gene_name": "MAP2K3", "organism": "Chicken", "refseq_name": "dual specificity mitogen-activated protein kinase kinase 3", "refseq_ac": [ { "id": "NP_001012805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012805", "type": "external" } ], "gene_names_uniprotkb": "MAP2K3", "gene_names_refseq": "MAP2K3", "protein_names_uniprotkb": "mitogen-activated protein kinase kinase; 2.7.12.2", "protein_names_refseq": "dual specificity mitogen-activated protein kinase kinase 3", "tax_id": 9031, "disease": "", "pathway": " (gga:416496); (R-GGA-2559580); (R-GGA-450302)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719928.1, SRR13267649.106596.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. On May 12, 2013 this sequence version replaced NP_001012805.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004708 MAP kinase kinase activity;GO:0019901 protein kinase binding", "go_cellular_component": "", "go_biological_process": "GO:1902531 regulation of intracellular signal transduction;GO:0000165 MAPK cascade;GO:0045893 positive regulation of DNA-templated transcription;GO:0043536 positive regulation of blood vessel endothelial cell migration;GO:0031098 stress-activated protein kinase signaling cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PD64-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PD65-1", "uniprot_id": [ { "id": "A0A1D5PD65_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PD65", "type": "external" } ], "mass": 27938.0, "length": 257, "protein_name": "Phosphatidylinositol-4,5-bisphosphate 4-phosphatase", "gene_name": "TMEM55A", "organism": "Chicken", "refseq_name": "type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase", "refseq_ac": [ { "id": "NP_001264349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264349", "type": "external" } ], "gene_names_uniprotkb": "TMEM55A", "gene_names_refseq": "PIP4P2; TMEM55A", "protein_names_uniprotkb": "Phosphatidylinositol-4,5-bisphosphate 4-phosphatase; 3.1.3.78", "protein_names_refseq": "phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2; type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase", "tax_id": 9031, "disease": "", "pathway": " (gga:420221)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CR386361.1, SRR13267653.15271.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000044.1. On Apr 7, 2013 this sequence version replaced XP_418331.2. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.78", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.78", "type": "external" } ], "go_molecular_function": "GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0005886 plasma membrane;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0046856 phosphatidylinositol dephosphorylation;GO:0050765 negative regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PD65-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PDB8-1", "uniprot_id": [ { "id": "A0A1D5PDB8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PDB8", "type": "external" } ], "mass": 52767.0, "length": 468, "protein_name": "Potassium channel subfamily K member 9", "gene_name": "KCNK9", "organism": "Chicken", "refseq_name": "potassium channel subfamily K member 9", "refseq_ac": [ { "id": "XP_003640905", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003640905", "type": "external" } ], "gene_names_uniprotkb": "KCNK9", "gene_names_refseq": "KCNK9", "protein_names_uniprotkb": "Potassium channel subfamily K member 9", "protein_names_refseq": "potassium channel subfamily K member 9", "tax_id": 9031, "disease": "", "pathway": " (gga:100859545); (R-GGA-1299316); (R-GGA-5576886)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 19, 2013 this sequence version replaced XP_003640905.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015271 outward rectifier potassium channel activity;GO:0022841 potassium ion leak channel activity;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0007601 visual perception;GO:0060075 regulation of resting membrane potential;GO:1990573 potassium ion import across plasma membrane;GO:0071468 cellular response to acidic pH;GO:0099605 regulation of action potential firing rate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PDB8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PDE8-1", "uniprot_id": [ { "id": "A0A1D5PDE8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PDE8", "type": "external" } ], "mass": 110887.0, "length": 972, "protein_name": "Kinesin-like protein", "gene_name": "KIF23", "organism": "Chicken", "refseq_name": "kinesin-like protein KIF23 isoform X1", "refseq_ac": [ { "id": "XP_015147590", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015147590", "type": "external" } ], "gene_names_uniprotkb": "KIF23", "gene_names_refseq": "KIF23", "protein_names_uniprotkb": "Kinesin-like protein", "protein_names_refseq": "kinesin-like protein KIF23 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6811434); (R-GGA-68884); (R-GGA-983189)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052541.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signaling. Required for the localization of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005871 kinesin complex", "go_biological_process": "GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0051256 mitotic spindle midzone assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PDE8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PDP9-1", "uniprot_id": [ { "id": "A0A1D5PDP9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PDP9", "type": "external" } ], "mass": 78185.0, "length": 697, "protein_name": "Hedgehog-interacting protein", "gene_name": "HHIP", "organism": "Chicken", "refseq_name": "hedgehog-interacting protein isoform X1", "refseq_ac": [ { "id": "XP_015132204", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015132204", "type": "external" } ], "gene_names_uniprotkb": "HHIP", "gene_names_refseq": "HHIP", "protein_names_uniprotkb": "Hedgehog-interacting protein", "protein_names_refseq": "hedgehog-interacting protein isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:422460); (R-GGA-5632681)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097108 hedgehog family protein binding;GO:0008270 zinc ion binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0048705 skeletal system morphogenesis;GO:0009968 negative regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PDP9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PDR6-1", "uniprot_id": [ { "id": "A0A1D5PDR6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PDR6", "type": "external" } ], "mass": 54607.0, "length": 488, "protein_name": "Limb development membrane protein 1 like", "gene_name": "LMBR1L", "organism": "Chicken", "refseq_name": "protein LMBR1L isoform X1", "refseq_ac": [ { "id": "XP_046760963", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046760963", "type": "external" } ], "gene_names_uniprotkb": "LMBR1L", "gene_names_refseq": "LMBR1L", "protein_names_uniprotkb": "Limb development membrane protein 1 like", "protein_names_refseq": "protein LMBR1L isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:107055406)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052565.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0060218 hematopoietic stem cell differentiation;GO:0006898 receptor-mediated endocytosis;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PDR6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PDT8-1", "uniprot_id": [ { "id": "A0A1D5PDT8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PDT8", "type": "external" } ], "mass": 43668.0, "length": 375, "protein_name": "Palmitoyltransferase", "gene_name": "ZDHHC16", "organism": "Chicken", "refseq_name": "palmitoyltransferase ZDHHC16 isoform X2", "refseq_ac": [ { "id": "XP_040531032", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040531032", "type": "external" } ], "gene_names_uniprotkb": "ZDHHC16", "gene_names_refseq": "ZDHHC16", "protein_names_uniprotkb": "Palmitoyltransferase; 2.3.1.225", "protein_names_refseq": "palmitoyltransferase ZDHHC16 isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052578.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0007507 heart development;GO:0006974 DNA damage response;GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PDT8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PE06-1", "uniprot_id": [ { "id": "A0A1D5PE06_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PE06", "type": "external" } ], "mass": 24671.0, "length": 217, "protein_name": "Homeobox B7", "gene_name": "HOXB7", "organism": "Chicken", "refseq_name": "homeobox protein Hox-B7 isoform X1", "refseq_ac": [ { "id": "XP_040509241", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040509241", "type": "external" } ], "gene_names_uniprotkb": "HOXB7", "gene_names_refseq": "HOXB7", "protein_names_uniprotkb": "Homeobox B7", "protein_names_refseq": "homeobox protein Hox-B7 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:425962)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052558.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification;GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PE06-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PE71-1", "uniprot_id": [ { "id": "A0A1D5PE71_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PE71", "type": "external" } ], "mass": 19207.0, "length": 162, "protein_name": "Transmembrane protein 138", "gene_name": "TMEM138", "organism": "Chicken", "refseq_name": "transmembrane protein 138", "refseq_ac": [ { "id": "NP_001264823", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264823", "type": "external" } ], "gene_names_uniprotkb": "TMEM138", "gene_names_refseq": "TMEM138", "protein_names_uniprotkb": "Transmembrane protein 138", "protein_names_refseq": "transmembrane protein 138", "tax_id": 9031, "disease": "", "pathway": " (gga:426323)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01006167.1, BX933755.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000212.1. On or before Apr 27, 2013 this sequence version replaced XP_423984.3, XP_003641320.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created with transcripts from different strains to make the sequence consistent with the reference genome assembly., [RefSeq]; Required for ciliogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0005774 vacuolar membrane", "go_biological_process": "GO:0060271 cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PE71-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PE93-1", "uniprot_id": [ { "id": "A0A1D5PE93_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PE93", "type": "external" } ], "mass": 117299.0, "length": 1038, "protein_name": "Non-SMC condensin I complex subunit G", "gene_name": "NCAPG", "organism": "Chicken", "refseq_name": "condensin complex subunit 3 isoform X1", "refseq_ac": [ { "id": "XP_025006124", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_025006124", "type": "external" } ], "gene_names_uniprotkb": "NCAPG", "gene_names_refseq": "NCAPG", "protein_names_uniprotkb": "Non-SMC condensin I complex subunit G", "protein_names_refseq": "condensin complex subunit 3 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:422822); (R-GGA-2514853)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005737 cytoplasm;GO:0000793 condensed chromosome;GO:0000796 condensin complex;GO:0000779 condensed chromosome, centromeric region", "go_biological_process": "GO:1905820 positive regulation of chromosome separation;GO:0051984 positive regulation of chromosome segregation;GO:0051301 cell division;GO:0007076 mitotic chromosome condensation;GO:1905821 positive regulation of chromosome condensation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PE93-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PE96-1", "uniprot_id": [ { "id": "A0A1D5PE96_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PE96", "type": "external" } ], "mass": 71786.0, "length": 637, "protein_name": "Plastin-3", "gene_name": "PLS3", "organism": "Chicken", "refseq_name": "plastin-3 isoform X1", "refseq_ac": [ { "id": "XP_015133719", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015133719", "type": "external" } ], "gene_names_uniprotkb": "PLS3", "gene_names_refseq": "PLS3; plastin-3", "protein_names_uniprotkb": "Plastin-3; T-plastin", "protein_names_refseq": "plastin-3 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XP_015133719.1. COMPLETENESS: full length., [RefSeq]; Actin-bundling protein., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005884 actin filament;GO:0032432 actin filament bundle", "go_biological_process": "GO:0051017 actin filament bundle assembly;GO:0060348 bone development;GO:0051639 actin filament network formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PE96-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PEI3-1", "uniprot_id": [ { "id": "A0A1D5PEI3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PEI3", "type": "external" } ], "mass": 44779.0, "length": 398, "protein_name": "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6", "gene_name": "ST8SIA6", "organism": "Chicken", "refseq_name": "alpha-2,8-sialyltransferase 8F precursor", "refseq_ac": [ { "id": "NP_001383496", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383496", "type": "external" } ], "gene_names_uniprotkb": "ST8SIA6", "gene_names_refseq": "SIAT8F; ST8SIA6", "protein_names_uniprotkb": "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6", "protein_names_refseq": "alpha-2,8-sialyltransferase 8F precursor; alpha-2,8-sialyltransferase 8F", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-4085001); (R-GGA-975577)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01069566.1, HAEK01053520.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000036.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity;GO:0008373 sialyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009311 oligosaccharide metabolic process;GO:0006491 N-glycan processing;GO:0001574 ganglioside biosynthetic process;GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PEI3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PEI4-1", "uniprot_id": [ { "id": "A0A1D5PEI4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PEI4", "type": "external" } ], "mass": 63946.0, "length": 580, "protein_name": "TOX high mobility group box family member 3", "gene_name": "TOX3", "organism": "Chicken", "refseq_name": "TOX high mobility group box family member 3 isoform 1", "refseq_ac": [ { "id": "NP_001264066", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264066", "type": "external" } ], "gene_names_uniprotkb": "TOX3", "gene_names_refseq": "TNRC9; TOX3", "protein_names_uniprotkb": "TOX high mobility group box family member 3", "protein_names_refseq": "TOX high mobility group box family member 3 isoform 1; trinucleotide repeat containing 9", "tax_id": 9031, "disease": "", "pathway": " (gga:415724)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "36794750", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267658.10924.1, SRR13267649.172458.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000248.1. On Mar 14, 2013 this sequence version replaced XP_414090.3. Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; DMRT1-mediated regulation of TOX3 modulates expansion of the gonadal steroidogenic cell lineage in the chicken embryo., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042803 protein homodimerization activity;GO:0051219 phosphoprotein binding;GO:0031490 chromatin DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5PEI4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PEY3-1", "uniprot_id": [ { "id": "A0A1D5PEY3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PEY3", "type": "external" } ], "mass": 51825.0, "length": 473, "protein_name": "CCR4-NOT transcription complex subunit 11", "gene_name": "CNOT11", "organism": "Chicken", "refseq_name": "CCR4-NOT transcription complex subunit 11", "refseq_ac": [ { "id": "XP_040517259", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040517259", "type": "external" } ], "gene_names_uniprotkb": "CNOT11", "gene_names_refseq": "CNOT11", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 11", "protein_names_refseq": "CCR4-NOT transcription complex subunit 11", "tax_id": 9031, "disease": "", "pathway": " (gga:418711); (R-GGA-429947); (R-GGA-6804115)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "37460791", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052573.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030014 CCR4-NOT complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0031047 regulatory ncRNA-mediated gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5PEY3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PF49-1", "uniprot_id": [ { "id": "A0A1D5PF49_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PF49", "type": "external" } ], "mass": 51492.0, "length": 480, "protein_name": "Cyclic AMP-dependent transcription factor ATF-7", "gene_name": "ATF7", "organism": "Chicken", "refseq_name": "cyclic AMP-dependent transcription factor ATF-7", "refseq_ac": [ { "id": "NP_001406868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001406868", "type": "external" } ], "gene_names_uniprotkb": "ATF7", "gene_names_refseq": "ATF7", "protein_names_uniprotkb": "Cyclic AMP-dependent transcription factor ATF-7", "protein_names_refseq": "cyclic AMP-dependent transcription factor ATF-7", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267654.136406.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## INFERRED REFSEQ: This record is predicted by genome sequence analysis and is not yet supported by experimental evidence. The reference sequence was derived from JAENSK010000489.1. On or before Apr 21, 2023 this sequence version replaced XP_025001216.1, XP_040549908.1., [RefSeq]; Stress-responsive chromatin regulator that plays a role in various biological processes including innate immunological memory, adipocyte differentiation or telomerase regulation. In absence of stress, contributes to the formation of heterochromatin and heterochromatin-like structure by recruiting histone H3K9 tri- and di-methyltransferases thus silencing the transcription of target genes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051019 mitogen-activated protein kinase binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001223 transcription coactivator binding;GO:0035497 cAMP response element binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PF49-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PF61-1", "uniprot_id": [ { "id": "A0A1D5PF61_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PF61", "type": "external" } ], "mass": 60536.0, "length": 537, "protein_name": "Synembryn", "gene_name": "RIC8B", "organism": "Chicken", "refseq_name": "synembryn-B isoform X1", "refseq_ac": [ { "id": "XP_416305", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_416305", "type": "external" } ], "gene_names_uniprotkb": "RIC8B", "gene_names_refseq": "RIC8B", "protein_names_uniprotkb": "Synembryn; Protein Ric-8", "protein_names_refseq": "synembryn-B isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:418069)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_416305.2. COMPLETENESS: full length., [RefSeq]; Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation. Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001965 G-protein alpha-subunit binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007608 sensory perception of smell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PF61-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PFF3-1", "uniprot_id": [ { "id": "A0A1D5PFF3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PFF3", "type": "external" } ], "mass": 62473.0, "length": 543, "protein_name": "Leucine-rich glioma-inactivated protein 1", "gene_name": "LGI1", "organism": "Chicken", "refseq_name": "leucine-rich glioma-inactivated protein 1 precursor", "refseq_ac": [ { "id": "NP_001038120", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001038120", "type": "external" } ], "gene_names_uniprotkb": "LGI1", "gene_names_refseq": "LGI1", "protein_names_uniprotkb": "Leucine-rich glioma-inactivated protein 1", "protein_names_refseq": "leucine-rich glioma-inactivated protein 1 precursor; leucine-rich glioma-inactivated protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:423802); (R-GGA-5682910)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01053822.1, SRR13267659.101025.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000232.1. On Dec 17, 2020 this sequence version replaced NP_001038120.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PMD5", "ec_number_list": [], "go_molecular_function": "GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0043083 synaptic cleft;GO:0005576 extracellular region", "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0007411 axon guidance;GO:0050806 positive regulation of synaptic transmission;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PFF3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PFG7-1", "uniprot_id": [ { "id": "A0A1D5PFG7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PFG7", "type": "external" } ], "mass": 27063.0, "length": 243, "protein_name": "Juxtaposed with another zinc finger protein 1", "gene_name": "JAZF1", "organism": "Chicken", "refseq_name": "juxtaposed with another zinc finger protein 1", "refseq_ac": [ { "id": "NP_001186547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186547", "type": "external" } ], "gene_names_uniprotkb": "JAZF1", "gene_names_refseq": "JAZF1", "protein_names_uniprotkb": "Juxtaposed with another zinc finger protein 1", "protein_names_refseq": "juxtaposed with another zinc finger protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:420633)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX931062.1, SRR13267655.221836.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992440, SAMN06140852 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000037.1. On Dec 11, 2010 this sequence version replaced XP_418732.2. Sequence Note: This RefSeq record was created from transcripts from different strains and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD. Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue. Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PFG7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PFI6-1", "uniprot_id": [ { "id": "A0A1D5PFI6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PFI6", "type": "external" } ], "mass": 107267.0, "length": 960, "protein_name": "DLG associated protein 3", "gene_name": "DLGAP3", "organism": "Chicken", "refseq_name": "disks large-associated protein 3 isoform X1", "refseq_ac": [ { "id": "XP_004947837", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004947837", "type": "external" } ], "gene_names_uniprotkb": "DLGAP3", "gene_names_refseq": "DLGAP3", "protein_names_uniprotkb": "DLG associated protein 3", "protein_names_refseq": "disks large-associated protein 3 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:419638); (R-GGA-6794361)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052554.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0001540 amyloid-beta binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0031594 neuromuscular junction;GO:0098981 cholinergic synapse;GO:0099572 postsynaptic specialization", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0023052 signaling;GO:0099010 modification of postsynaptic structure", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PFI6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PFJ3-1", "uniprot_id": [ { "id": "A0A1D5PFJ3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PFJ3", "type": "external" } ], "mass": 40681.0, "length": 363, "protein_name": "protein-tyrosine-phosphatase", "gene_name": "PTPN7", "organism": "Chicken", "refseq_name": "tyrosine-protein phosphatase non-receptor type 7 isoform X1", "refseq_ac": [ { "id": "XP_015154249", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015154249", "type": "external" } ], "gene_names_uniprotkb": "PTPN7", "gene_names_refseq": "PTPN7", "protein_names_uniprotkb": "protein-tyrosine-phosphatase; 3.1.3.48", "protein_names_refseq": "tyrosine-protein phosphatase non-receptor type 7 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:770905)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052557.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PFJ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PFR7-1", "uniprot_id": [ { "id": "A0A1D5PFR7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PFR7", "type": "external" } ], "mass": 14374.0, "length": 121, "protein_name": "Microtubule associated protein 1 light chain 3 alpha", "gene_name": "MAP1LC3A", "organism": "Chicken", "refseq_name": "microtubule-associated proteins 1A/1B light chain 3A", "refseq_ac": [ { "id": "XP_417327", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_417327", "type": "external" } ], "gene_names_uniprotkb": "MAP1LC3A", "gene_names_refseq": "MAP1LC3A", "protein_names_uniprotkb": "Microtubule associated protein 1 light chain 3 alpha", "protein_names_refseq": "microtubule-associated proteins 1A/1B light chain 3A", "tax_id": 9031, "disease": "", "pathway": " (gga:419142); (R-GGA-1632852); (R-GGA-5205685); (R-GGA-8934903)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052551.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_417327.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031625 ubiquitin protein ligase binding;GO:0008429 phosphatidylethanolamine binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005874 microtubule;GO:0031410 cytoplasmic vesicle;GO:0005829 cytosol;GO:0044754 autolysosome", "go_biological_process": "GO:0006914 autophagy;GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0000423 mitophagy;GO:0006995 cellular response to nitrogen starvation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PFR7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PFS2-1", "uniprot_id": [ { "id": "A0A1D5PFS2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PFS2", "type": "external" } ], "mass": 36553.0, "length": 313, "protein_name": "Ras-related GTP-binding protein", "gene_name": "RRAGA", "organism": "Chicken", "refseq_name": "ras-related GTP-binding protein A isoform X1", "refseq_ac": [ { "id": "XP_015134056", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015134056", "type": "external" } ], "gene_names_uniprotkb": "RRAGA", "gene_names_refseq": "RRAGA", "protein_names_uniprotkb": "Ras-related GTP-binding protein", "protein_names_refseq": "ras-related GTP-binding protein A isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:422311); (R-GGA-1632852); (R-GGA-165159); (R-GGA-166208); (R-GGA-380972); (R-GGA-5628897); (R-GGA-8866654); (R-GGA-8943724); (R-GGA-9639288)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0003924 GTPase activity;GO:0051020 GTPase binding", "go_cellular_component": "GO:0005764 lysosome;GO:0012505 endomembrane system;GO:0005634 nucleus;GO:1990131 Gtr1-Gtr2 GTPase complex", "go_biological_process": "GO:0032008 positive regulation of TOR signaling;GO:0071230 cellular response to amino acid stimulus;GO:1904263 positive regulation of TORC1 signaling;GO:0010507 negative regulation of autophagy;GO:0008104 intracellular protein localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PFS2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PFT4-1", "uniprot_id": [ { "id": "A0A1D5PFT4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PFT4", "type": "external" } ], "mass": 46036.0, "length": 418, "protein_name": "SS18, nBAF chromatin remodeling complex subunit", "gene_name": "SS18", "organism": "Chicken", "refseq_name": "protein SSXT isoform 1", "refseq_ac": [ { "id": "NP_001265079", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265079", "type": "external" } ], "gene_names_uniprotkb": "SS18", "gene_names_refseq": "SS18", "protein_names_uniprotkb": "SS18, nBAF chromatin remodeling complex subunit", "protein_names_refseq": "protein SSXT isoform 1; protein SSXT; synovial sarcoma translocation, chromosome 18", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-9933937); (R-GGA-9933946); (R-GGA-9933947); (R-GGA-9934037)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267655.13864.1, HAEK01042214.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000043.1. On Sep 23, 2021 this sequence version replaced NP_001265079.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016514 SWI/SNF complex;GO:0071564 npBAF complex;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PFT4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PG09-1", "uniprot_id": [ { "id": "A0A1D5PG09_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PG09", "type": "external" } ], "mass": 42317.0, "length": 390, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "MARCHF4", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MARCHF4", "gene_names_refseq": "", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:424221)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005795 Golgi stack;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PG09-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PGA5-1", "uniprot_id": [ { "id": "A0A1D5PGA5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PGA5", "type": "external" } ], "mass": 48584.0, "length": 432, "protein_name": "Transcriptional enhancer factor TEF-3", "gene_name": "TEAD4", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TEAD4", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcriptional enhancer factor TEF-3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395542); (R-GGA-2032785); (R-GGA-8951671)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0035329 hippo signaling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048568 embryonic organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PGA5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PGF8-1", "uniprot_id": [ { "id": "A0A1D5PGF8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PGF8", "type": "external" } ], "mass": 56095.0, "length": 485, "protein_name": "SWI/SNF related BAF chromatin remodeling complex subunit D3", "gene_name": "SMARCD3", "organism": "Chicken", "refseq_name": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X3", "refseq_ac": [ { "id": "XP_015136521", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015136521", "type": "external" } ], "gene_names_uniprotkb": "SMARCD3", "gene_names_refseq": "SMARCD3", "protein_names_uniprotkb": "SWI/SNF related BAF chromatin remodeling complex subunit D3", "protein_names_refseq": "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:430336); (R-GGA-3214858); (R-GGA-8939243); (R-GGA-9933939); (R-GGA-9933946); (R-GGA-9933947); (R-GGA-9934037)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus;GO:0016514 SWI/SNF complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PGF8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PGJ8-1", "uniprot_id": [ { "id": "A0A1D5PGJ8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PGJ8", "type": "external" } ], "mass": 15575.0, "length": 141, "protein_name": "Transmembrane protein 216", "gene_name": "TMEM216", "organism": "Chicken", "refseq_name": "transmembrane protein 216", "refseq_ac": [ { "id": "XP_001236892", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001236892", "type": "external" } ], "gene_names_uniprotkb": "TMEM216", "gene_names_refseq": "TMEM216", "protein_names_uniprotkb": "Transmembrane protein 216", "protein_names_refseq": "transmembrane protein 216", "tax_id": 9031, "disease": "", "pathway": " (gga:777441); (R-GGA-5620912)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_001236892.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016020 membrane;GO:0036038 MKS complex;GO:0035869 ciliary transition zone", "go_biological_process": "GO:0030030 cell projection organization;GO:0045880 positive regulation of smoothened signaling pathway;GO:1905515 non-motile cilium assembly;GO:0045724 positive regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PGJ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PGR9-1", "uniprot_id": [ { "id": "A0A1D5PGR9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PGR9", "type": "external" } ], "mass": 43894.0, "length": 374, "protein_name": "Hexosyltransferase", "gene_name": "B3GNT5", "organism": "Chicken", "refseq_name": "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase", "refseq_ac": [ { "id": "NP_001107233", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107233", "type": "external" } ], "gene_names_uniprotkb": "B3GNT5", "gene_names_refseq": "B3GNT5", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase", "tax_id": 9031, "disease": "", "pathway": " (gga:424960); (R-GGA-913709); (R-GGA-9840309)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000240.1. On Jan 26, 2008 this sequence version replaced XP_422769.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0016757 glycosyltransferase activity;GO:0047256 lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PGR9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PGS3-1", "uniprot_id": [ { "id": "A0A1D5PGS3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PGS3", "type": "external" } ], "mass": 21236.0, "length": 182, "protein_name": "Outer dense fiber protein 1", "gene_name": "ODF1", "organism": "Chicken", "refseq_name": "uncharacterized protein ODF1 isoform X1", "refseq_ac": [ { "id": "XP_040519520", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040519520", "type": "external" } ], "gene_names_uniprotkb": "ODF1", "gene_names_refseq": "ODF1", "protein_names_uniprotkb": "Outer dense fiber protein 1", "protein_names_refseq": "uncharacterized protein ODF1 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052574.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0031514 motile cilium;GO:0099513 polymeric cytoskeletal fiber", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PGS3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PH80-1", "uniprot_id": [ { "id": "A0A1D5PH80_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PH80", "type": "external" } ], "mass": 35574.0, "length": 335, "protein_name": "3-hydroxyisobutyrate dehydrogenase", "gene_name": "HIBADH", "organism": "Chicken", "refseq_name": "3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_046767131", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046767131", "type": "external" } ], "gene_names_uniprotkb": "HIBADH", "gene_names_refseq": "HIBADH", "protein_names_uniprotkb": "3-hydroxyisobutyrate dehydrogenase; 1.1.1.31; HIBADH", "protein_names_refseq": "3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-70895)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052574.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.31", "type": "external" } ], "go_molecular_function": "GO:0051287 NAD binding;GO:0008442 3-hydroxyisobutyrate dehydrogenase activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006574 L-valine catabolic process;GO:0009083 branched-chain amino acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PH80-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PHP9-1", "uniprot_id": [ { "id": "A0A1D5PHP9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PHP9", "type": "external" } ], "mass": 40591.0, "length": 374, "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "organism": "Chicken", "refseq_name": "wnt inhibitory factor 1 precursor", "refseq_ac": [ { "id": "NP_001186536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186536", "type": "external" } ], "gene_names_uniprotkb": "WIF1", "gene_names_refseq": "WIF1", "protein_names_uniprotkb": "Wnt inhibitory factor 1", "protein_names_refseq": "Wnt inhibitory factor-1; wnt inhibitory factor 1 precursor", "tax_id": 9031, "disease": "", "pathway": " (gga:417831)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19755491;21179454", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267662.9883.1, SRR13267655.124238.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000012.1. On Mar 18, 2015 this sequence version replaced NP_001186536.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same breed was available for the full length of the gene. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These results identify Wif-1 as a novel extracellular Wnt modulator in cartilage biology., [RefSeq, PubMed]; Wif1 is a modulator of cardiomyocyte differentiation Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1D5PHP9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PHS5-1", "uniprot_id": [ { "id": "A0A1D5PHS5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PHS5", "type": "external" } ], "mass": 34178.0, "length": 297, "protein_name": "GTP-binding protein", "gene_name": "GEM", "organism": "Chicken", "refseq_name": "GTP-binding protein GEM", "refseq_ac": [ { "id": "NP_998744", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_998744", "type": "external" } ], "gene_names_uniprotkb": "GEM", "gene_names_refseq": "GEM", "protein_names_uniprotkb": "GTP-binding protein", "protein_names_refseq": "GTP-binding protein GEM; Gem GTPase", "tax_id": 9031, "disease": "", "pathway": " (gga:404771)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01010008.1, HAEK01073442.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000044.1. On Sep 23, 2021 this sequence version replaced NP_998744.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005516 calmodulin binding;GO:0005525 GTP binding;GO:0000287 magnesium ion binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0051233 spindle midzone;GO:0009898 cytoplasmic side of plasma membrane;GO:0030496 midbody", "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0000278 mitotic cell cycle;GO:0051276 chromosome organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PHS5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PI06-1", "uniprot_id": [ { "id": "A0A1D5PI06_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PI06", "type": "external" } ], "mass": 26893.0, "length": 245, "protein_name": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial", "gene_name": "NDUFV2", "organism": "Chicken", "refseq_name": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_424129", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_424129", "type": "external" } ], "gene_names_uniprotkb": "NDUFV2", "gene_names_refseq": "NDUFV2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial; 7.1.1.2; NADH-ubiquinone oxidoreductase 24 kDa subunit", "protein_names_refseq": "NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:426488); (R-GGA-611105); (R-GGA-6799198)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_424129.3. COMPLETENESS: full length., [RefSeq]; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Parts of the peripheral arm of the enzyme, where the electrons from NADH are accepted by flavin mononucleotide (FMN) and then passed along a chain of iron-sulfur clusters by electron tunnelling to the final acceptor ubiquinone. Contains one iron-sulfur cluster., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "2.1.1.320", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.320", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0007399 nervous system development;GO:0048738 cardiac muscle tissue development;GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PI06-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PI40-1", "uniprot_id": [ { "id": "A0A1D5PI40_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PI40", "type": "external" } ], "mass": 26386.0, "length": 235, "protein_name": "Empty spiracles homeobox 1", "gene_name": "EMX1", "organism": "Chicken", "refseq_name": "homeobox protein EMX1", "refseq_ac": [ { "id": "XP_001232151", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001232151", "type": "external" } ], "gene_names_uniprotkb": "EMX1", "gene_names_refseq": "EMX1", "protein_names_uniprotkb": "Empty spiracles homeobox 1", "protein_names_refseq": "homeobox protein EMX1", "tax_id": 9031, "disease": "", "pathway": " (gga:768977)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_001232151.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0007420 brain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PI40-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PI43-1", "uniprot_id": [ { "id": "A0A1D5PI43_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PI43", "type": "external" } ], "mass": 58575.0, "length": 521, "protein_name": "Amine oxidase", "gene_name": "MAOB", "organism": "Chicken", "refseq_name": "amine oxidase [flavin-containing] B isoform X1", "refseq_ac": [ { "id": "XP_416766", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_416766", "type": "external" } ], "gene_names_uniprotkb": "MAOB", "gene_names_refseq": "MAOB", "protein_names_uniprotkb": "Amine oxidase; 1.4.3.-", "protein_names_refseq": "amine oxidase [flavin-containing] B isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:418561)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_416766.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.4", "type": "external" }, { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" } ], "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0042428 serotonin metabolic process;GO:0019607 phenylethylamine catabolic process;GO:0009308 amine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PI43-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PI60-1", "uniprot_id": [ { "id": "A0A1D5PI60_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PI60", "type": "external" } ], "mass": 64455.0, "length": 580, "protein_name": "Potassium voltage-gated channel subfamily A member 3", "gene_name": "KCNA3", "organism": "Chicken", "refseq_name": "potassium voltage-gated channel subfamily A member 3", "refseq_ac": [ { "id": "NP_001025549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025549", "type": "external" } ], "gene_names_uniprotkb": "KCNA3", "gene_names_refseq": "KCNA3; cKv1.1", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 3", "protein_names_refseq": "Shaker-like voltage-gated potassium channel cKv1.1; potassium voltage-gated channel subfamily A member 3; potassium voltage-gated channel, shaker-related subfamily, member 3; shaker subfamily potassium channel Kv1.3 alpha subunit; voltage-gated Kv1.3 potassium channel", "tax_id": 9031, "disease": "", "pathway": " (gga:404303); (R-GGA-1296072)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000356.1. On Dec 3, 2021 this sequence version replaced NP_001025549.1. Transcript Variant: This variant (1) is intronless. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0030424 axon;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PI60-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PI98-1", "uniprot_id": [ { "id": "A0A1D5PI98_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PI98", "type": "external" } ], "mass": 103078.0, "length": 913, "protein_name": "Potassium voltage-gated channel subfamily B member 2", "gene_name": "KCNB2", "organism": "Chicken", "refseq_name": "potassium voltage-gated channel subfamily B member 2", "refseq_ac": [ { "id": "XP_003640873", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003640873", "type": "external" } ], "gene_names_uniprotkb": "KCNB2", "gene_names_refseq": "KCNB2", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily B member 2", "protein_names_refseq": "potassium voltage-gated channel subfamily B member 2", "tax_id": 9031, "disease": "", "pathway": " (gga:431181); (R-GGA-1296072)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XP_003640873.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0016020 membrane;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043204 perikaryon;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PI98-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PIE4-1", "uniprot_id": [ { "id": "A0A1D5PIE4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PIE4", "type": "external" } ], "mass": 50010.0, "length": 450, "protein_name": "Antizyme inhibitor 1", "gene_name": "AZIN1", "organism": "Chicken", "refseq_name": "antizyme inhibitor 1", "refseq_ac": [ { "id": "NP_001008729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008729", "type": "external" } ], "gene_names_uniprotkb": "AZIN1", "gene_names_refseq": "AZIN1; OAZIN", "protein_names_uniprotkb": "Antizyme inhibitor 1; Ornithine decarboxylase antizyme inhibitor", "protein_names_refseq": "antizyme inhibitor 1; ornithine decarboxylase antizyme inhibitor", "tax_id": 9031, "disease": "", "pathway": " (gga:420254); (R-GGA-350562)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01001192.1, AJ720630.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992533 [ECO:0000348] ##Evidence-Data-END## REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU463028.1, AJ720630.1, CN226049.1, DR414120.1, DR431376.1 and BU350527.1. On Jan 12, 2005 this sequence version replaced XP_418365.1. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. [provided by RefSeq, Sep 2014]., [RefSeq]; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004586 ornithine decarboxylase activity;GO:0042978 ornithine decarboxylase activator activity;GO:0003824 catalytic activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0042177 negative regulation of protein catabolic process;GO:0033387 putrescine biosynthetic process from arginine, via ornithine;GO:1902269 positive regulation of polyamine transmembrane transport;GO:0006596 polyamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PIE4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PIG9-1", "uniprot_id": [ { "id": "A0A1D5PIG9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PIG9", "type": "external" } ], "mass": 28544.0, "length": 262, "protein_name": "tRNA wybutosine-synthesizing protein 3 homolog", "gene_name": "TYW3", "organism": "Chicken", "refseq_name": "tRNA wybutosine-synthesizing protein 3 homolog", "refseq_ac": [ { "id": "NP_001264564", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264564", "type": "external" } ], "gene_names_uniprotkb": "TYW3", "gene_names_refseq": "TYW3", "protein_names_uniprotkb": "tRNA wybutosine-synthesizing protein 3 homolog; 2.1.1.282; tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase", "protein_names_refseq": "tRNA wybutosine-synthesizing protein 3 homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:424720)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU358977.1, HAEK01192574.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000239.1. On Apr 13, 2013 this sequence version replaced XP_422546.3. Sequence Note: This RefSeq record was created from genomic sequence and transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.282", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.282", "type": "external" } ], "go_molecular_function": "GO:0008175 tRNA methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0030488 tRNA methylation;GO:0031591 wybutosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PIG9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PIN1-1", "uniprot_id": [ { "id": "A0A1D5PIN1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PIN1", "type": "external" } ], "mass": 27159.0, "length": 248, "protein_name": "Protein-L-isoaspartate O-methyltransferase", "gene_name": "PCMT1L", "organism": "Chicken", "refseq_name": "l-isoaspartyl protein carboxyl methyltransferase, like isoform 1 precursor", "refseq_ac": [ { "id": "NP_001264331", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264331", "type": "external" } ], "gene_names_uniprotkb": "PCMT1L", "gene_names_refseq": "PCMT1L", "protein_names_uniprotkb": "Protein-L-isoaspartate O-methyltransferase; 2.1.1.77", "protein_names_refseq": "l-isoaspartyl protein carboxyl methyltransferase, like isoform 1 precursor; l-isoaspartyl protein carboxyl methyltransferase, like", "tax_id": 9031, "disease": "", "pathway": " (gga:423008)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01021968.1, HAEK01111301.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CD215924.1, BX929703.2, BU383489.1 and BU202796.1. On Apr 6, 2013 this sequence version replaced XP_420939.3. Transcript Variant: This variant (1) encodes the longer isoform (1)., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.77", "type": "external" } ], "go_molecular_function": "GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PIN1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PIT5-1", "uniprot_id": [ { "id": "A0A1D5PIT5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PIT5", "type": "external" } ], "mass": 42419.0, "length": 379, "protein_name": "Modulator of VRAC current 1", "gene_name": "MLC1", "organism": "Chicken", "refseq_name": "membrane protein MLC1 isoform X1", "refseq_ac": [ { "id": "XP_004937559", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004937559", "type": "external" } ], "gene_names_uniprotkb": "MLC1", "gene_names_refseq": "MLC1", "protein_names_uniprotkb": "Modulator of VRAC current 1", "protein_names_refseq": "membrane protein MLC1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:417737)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1RVT3;A0A1L1RZL8", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0032388 positive regulation of intracellular transport;GO:0047484 regulation of response to osmotic stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PIT5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PIX2-1", "uniprot_id": [ { "id": "A0A1D5PIX2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PIX2", "type": "external" } ], "mass": 69686.0, "length": 604, "protein_name": "Kelch-like protein 15", "gene_name": "KLHL15", "organism": "Chicken", "refseq_name": "kelch-like protein 15 isoform 1", "refseq_ac": [ { "id": "NP_001137142", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137142", "type": "external" } ], "gene_names_uniprotkb": "KLHL15", "gene_names_refseq": "KLHL15", "protein_names_uniprotkb": "Kelch-like protein 15", "protein_names_refseq": "kelch like family member 15; kelch-like 15; kelch-like protein 15 isoform 1", "tax_id": 9031, "disease": "", "pathway": " (gga:418598)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267654.165721.1, SRR13267652.15618.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000021.1. Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5PHT3", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0016567 protein ubiquitination;GO:0071630 nuclear protein quality control by the ubiquitin-proteasome system", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PIX2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PIZ8-1", "uniprot_id": [ { "id": "A0A1D5PIZ8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PIZ8", "type": "external" } ], "mass": 189625.0, "length": 1658, "protein_name": "IQ motif containing GTPase activating protein 3", "gene_name": "IQGAP1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IQGAP1", "gene_names_refseq": "", "protein_names_uniprotkb": "IQ motif containing GTPase activating protein 3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:415591); (R-GGA-5626467); (R-GGA-5674135); (R-GGA-6798695); (R-GGA-8980692); (R-GGA-9013106); (R-GGA-9013149); (R-GGA-9013404); (R-GGA-9013406); (R-GGA-9013420); (R-GGA-9013424)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005096 GTPase activator activity;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0120025 plasma membrane bounded cell projection;GO:0005634 nucleus;GO:0005874 microtubule;GO:0005938 cell cortex;GO:0030054 cell junction", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0043410 positive regulation of MAPK cascade;GO:0071277 cellular response to calcium ion;GO:0007346 regulation of mitotic cell cycle;GO:0007173 epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PIZ8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PJ69-1", "uniprot_id": [ { "id": "A0A1D5PJ69_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PJ69", "type": "external" } ], "mass": 100923.0, "length": 902, "protein_name": "Glutamate receptor", "gene_name": "GRIA4", "organism": "Chicken", "refseq_name": "glutamate receptor 4 isoform 2 precursor", "refseq_ac": [ { "id": "NP_990545", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990545", "type": "external" } ], "gene_names_uniprotkb": "GRIA4", "gene_names_refseq": "GLUR4/D; GRIA4; GluR4c; GluR4d; GluR4s; GluR4", "protein_names_uniprotkb": "Glutamate receptor", "protein_names_refseq": "AMPA receptor GluR4/D; glutamate receptor 4 isoform 2 precursor; glutamate receptor 4; glutamate receptor subunit GluR4; glutamate receptor, ionotrophic, AMPA 4; glutamate receptor, ionotropic, AMPA 4", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-399710); (R-GGA-416993); (R-GGA-438066); (R-GGA-8849932)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "15255946;17233759", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: X89507.1, SRR13267649.254949.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## undergoes RNA editing :: PMID: 10688364 ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000027.1. On Dec 3, 2021 this sequence version replaced NP_990545.1. Transcript Variant: This variant (2) uses an alternate internal coding exon compared to transcript variant 1, and encodes an isoform (2, also known as flop isoform) that is the same length, but with a few amino acid differences compared to isoform 1. RNA editing (AGA->GGA) changes Arg765Gly., [RefSeq]; Our data show that GluR4 phosphorylation at Ser842 by PKA, and its recruitment to the plasma membrane upon phosphorylation, is regulated by metabotropic receptors, [RefSeq, PubMed]; Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The present findings show that the interaction between PKCgamma and GluR4 is specifically required to assure PKC-driven phosphorylation and surface membrane expression of GluR4., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential;GO:0004971 AMPA glutamate receptor activity;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential;GO:0015276 ligand-gated monoatomic ion channel activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0032281 AMPA glutamate receptor complex;GO:0098839 postsynaptic density membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0035249 synaptic transmission, glutamatergic;GO:0050804 modulation of chemical synaptic transmission;GO:0034392 negative regulation of smooth muscle cell apoptotic process;GO:0007166 cell surface receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1D5PJ69-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PJC6-1", "uniprot_id": [ { "id": "A0A1D5PJC6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PJC6", "type": "external" } ], "mass": 35895.0, "length": 315, "protein_name": "Serine/threonine-protein phosphatase CPPED1", "gene_name": "CPPED1", "organism": "Chicken", "refseq_name": "serine/threonine-protein phosphatase CPPED1", "refseq_ac": [ { "id": "NP_001153454", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153454", "type": "external" } ], "gene_names_uniprotkb": "CPPED1", "gene_names_refseq": "CPPED1", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase CPPED1; 3.1.3.16; Calcineurin-like phosphoesterase domain-containing protein 1", "protein_names_refseq": "serine/threonine-protein phosphatase CPPED1", "tax_id": 9031, "disease": "", "pathway": " (gga:416418); (R-GGA-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01009836.1, BX936038.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000257.1. On May 9, 2009 this sequence version replaced XP_414732.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PJC6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PJE0-1", "uniprot_id": [ { "id": "A0A1D5PJE0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PJE0", "type": "external" } ], "mass": 75142.0, "length": 654, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase", "gene_name": "GALNT7", "organism": "Chicken", "refseq_name": "N-acetylgalactosaminyltransferase 7 isoform X2", "refseq_ac": [ { "id": "XP_040555059", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040555059", "type": "external" } ], "gene_names_uniprotkb": "GALNT7", "gene_names_refseq": "GALNT7", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase; 2.4.1.-; Protein-UDP acetylgalactosaminyltransferase", "protein_names_refseq": "N-acetylgalactosaminyltransferase 7 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:422561); (R-GGA-913709)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Glycopeptide transferase involved in O-linked oligosaccharide biosynthesis, which catalyzes the transfer of an N-acetyl-D-galactosamine residue to an already glycosylated peptide. In contrast to other proteins of the family, it does not act as a peptide transferase that transfers GalNAc onto serine or threonine residue on the protein receptor, but instead requires the prior addition of a GalNAc on a peptide before adding additional GalNAc moieties. Some peptide transferase activity is however not excluded, considering that its appropriate peptide substrate may remain unidentified., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PJE0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PJJ4-1", "uniprot_id": [ { "id": "A0A1D5PJJ4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PJJ4", "type": "external" } ], "mass": 10582.0, "length": 94, "protein_name": "Protein S100", "gene_name": "S100A1", "organism": "Chicken", "refseq_name": "protein S100-A1", "refseq_ac": [ { "id": "NP_001289102", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289102", "type": "external" } ], "gene_names_uniprotkb": "S100A1", "gene_names_refseq": "S100A1", "protein_names_uniprotkb": "Protein S100; S100 calcium-binding protein", "protein_names_refseq": "protein S100-A1", "tax_id": 9031, "disease": "", "pathway": " (gga:100858258); (R-GGA-5686938)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX933835.1, SRR13267662.7011.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992437 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000349.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0051117 ATPase binding;GO:0005509 calcium ion binding;GO:0044548 S100 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0042311 vasodilation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PJJ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PJK3-1", "uniprot_id": [ { "id": "A0A1D5PJK3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PJK3", "type": "external" } ], "mass": 39772.0, "length": 351, "protein_name": "AKT interacting protein", "gene_name": "AKTIP", "organism": "Chicken", "refseq_name": "AKT-interacting protein isoform X1", "refseq_ac": [ { "id": "XP_046755380", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046755380", "type": "external" } ], "gene_names_uniprotkb": "AKTIP", "gene_names_refseq": "AKTIP; FTS", "protein_names_uniprotkb": "AKT interacting protein", "protein_names_refseq": "AKT-interacting protein isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0030897 HOPS complex;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0070695 FHF complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0015031 protein transport;GO:0006915 apoptotic process;GO:0007032 endosome organization;GO:0007040 lysosome organization;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PJK3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PJW4-1", "uniprot_id": [ { "id": "A0A1D5PJW4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PJW4", "type": "external" } ], "mass": 27872.0, "length": 248, "protein_name": "Proteasome subunit alpha type", "gene_name": "PSMA7", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PSMA7", "gene_names_refseq": "", "protein_names_uniprotkb": "Proteasome subunit alpha type", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395318); (R-GGA-1169091); (R-GGA-1234176); (R-GGA-1236978); (R-GGA-174084); (R-GGA-174154); (R-GGA-174178); (R-GGA-174184); (R-GGA-187577); (R-GGA-195253); (R-GGA-202424); (R-GGA-2467813); (R-GGA-2871837); (R-GGA-349425); (R-GGA-350562); (R-GGA-382556); (R-GGA-450408); (R-GGA-4608870); (R-GGA-4641257); (R-GGA-4641258); (R-GGA-5358346); (R-GGA-5607764); (R-GGA-5610780); (R-GGA-5610785); (R-GGA-5632684); (R-GGA-5658442); (R-GGA-5668541); (R-GGA-5687128); (R-GGA-5689603); (R-GGA-5689880); (R-GGA-68867); (R-GGA-68949); (R-GGA-69017); (R-GGA-69601); (R-GGA-75815); (R-GGA-8854050); (R-GGA-8939236); (R-GGA-8939902); (R-GGA-8941858); (R-GGA-8948751); (R-GGA-8951664); (R-GGA-9020702); (R-GGA-9755511); (R-GGA-9762114); (R-GGA-9766229); (R-GGA-983168); (R-GGA-9907900); (R-GGA-9929356); (R-GGA-9929491); (R-GGA-9931269); (R-GGA-9932298); (R-GGA-9954709)", "pathway_count": 52, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0019773 proteasome core complex, alpha-subunit complex", "go_biological_process": "GO:0006979 response to oxidative stress;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0061136 regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PJW4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PJZ5-1", "uniprot_id": [ { "id": "A0A1D5PJZ5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PJZ5", "type": "external" } ], "mass": 14844.0, "length": 132, "protein_name": "Myelin P2 protein", "gene_name": "FABP9", "organism": "Chicken", "refseq_name": "myelin P2 protein", "refseq_ac": [ { "id": "NP_001186405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186405", "type": "external" } ], "gene_names_uniprotkb": "FABP9", "gene_names_refseq": "FABP9; PMP2", "protein_names_uniprotkb": "Myelin P2 protein", "protein_names_refseq": "myelin P2 protein; peripheral myelin protein 2", "tax_id": 9031, "disease": "", "pathway": " (gga:420198); (R-GGA-163560)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01130153.1, HAEK01048479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992415 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000044.1. On Dec 10, 2010 this sequence version replaced XP_418309.1. Sequence Note: This RefSeq record was created from transcripts from different strains and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; May play a role in lipid transport protein in Schwann cells. May bind cholesterol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005504 fatty acid binding;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0043209 myelin sheath", "go_biological_process": "GO:0061024 membrane organization;GO:0015908 fatty acid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PJZ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PKA7-1", "uniprot_id": [ { "id": "A0A1D5PKA7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PKA7", "type": "external" } ], "mass": 69377.0, "length": 660, "protein_name": "Dachshund family transcription factor 1", "gene_name": "DACH1", "organism": "Chicken", "refseq_name": "dachshund homolog 1", "refseq_ac": [ { "id": "NP_001186375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186375", "type": "external" } ], "gene_names_uniprotkb": "DACH1", "gene_names_refseq": "DACH1; DACH", "protein_names_uniprotkb": "Dachshund family transcription factor 1", "protein_names_refseq": "dachshund homolog 1", "tax_id": 9031, "disease": "", "pathway": " (gga:373935)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15280207", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888548.202011.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000027.1. On Dec 7, 2010 this sequence version replaced XP_417018.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Dach1 interacts with the Smad complex and Sin3a and has a role in controlling AER formation and limb development, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0033262 regulation of nuclear cell cycle DNA replication;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030336 negative regulation of cell migration;GO:2000279 negative regulation of DNA biosynthetic process;GO:0010944 negative regulation of transcription by competitive promoter binding", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5PKA7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PKC2-1", "uniprot_id": [ { "id": "A0A1D5PKC2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PKC2", "type": "external" } ], "mass": 24083.0, "length": 212, "protein_name": "Thymidylate kinase", "gene_name": "DTYMK", "organism": "Chicken", "refseq_name": "thymidylate kinase", "refseq_ac": [ { "id": "NP_001265279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265279", "type": "external" } ], "gene_names_uniprotkb": "DTYMK", "gene_names_refseq": "DTYMK", "protein_names_uniprotkb": "Thymidylate kinase; 2.7.4.9; dTMP kinase", "protein_names_refseq": "deoxythymidylate kinase (thymidylate kinase); thymidylate kinase", "tax_id": 9031, "disease": "", "pathway": " (gga:770258); (R-GGA-499943)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX935908.2, BU112483.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000240.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP, with ATP as the preferred phosphoryl donor in the presence of Mg(2+)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.9", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004798 dTMP kinase activity;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006233 dTDP biosynthetic process;GO:0006227 dUDP biosynthetic process;GO:0006235 dTTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PKC2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PKJ0-1", "uniprot_id": [ { "id": "A0A1D5PKJ0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PKJ0", "type": "external" } ], "mass": 16390.0, "length": 139, "protein_name": "Transmembrane protein 250", "gene_name": "C9orf69", "organism": "Chicken", "refseq_name": "transmembrane protein 250", "refseq_ac": [ { "id": "NP_001269249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269249", "type": "external" } ], "gene_names_uniprotkb": "C9orf69", "gene_names_refseq": "C17H9orf69; C9orf69; TMEM250", "protein_names_uniprotkb": "Transmembrane protein 250", "protein_names_refseq": "transmembrane protein 250", "tax_id": 9031, "disease": "", "pathway": " (gga:100859101)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CR389213.1, BU489634.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000308.1. On Aug 31, 2013 this sequence version replaced XP_003642343.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0048524 positive regulation of viral process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PKJ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PKK0-1", "uniprot_id": [ { "id": "A0A1D5PKK0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PKK0", "type": "external" } ], "mass": 33261.0, "length": 318, "protein_name": "Pyrroline-5-carboxylate reductase", "gene_name": "PYCR1", "organism": "Chicken", "refseq_name": "pyrroline-5-carboxylate reductase 1, mitochondrial", "refseq_ac": [ { "id": "NP_001279000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001279000", "type": "external" } ], "gene_names_uniprotkb": "PYCR1", "gene_names_refseq": "PYCR1; PYCR2", "protein_names_uniprotkb": "Pyrroline-5-carboxylate reductase; 1.5.1.2", "protein_names_refseq": "pyrroline-5-carboxylate reductase 1, mitochondrial; pyrroline-5-carboxylate reductase 2; pyrroline-5-carboxylate reductase family, member 2", "tax_id": 9031, "disease": "", "pathway": " (gga:769203); (R-GGA-8964539)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01027829.1, HAEK01107920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA3109053 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000317.1. On May 21, 2014 this sequence version replaced XP_001232432.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.1.2", "type": "external" } ], "go_molecular_function": "GO:0004735 pyrroline-5-carboxylate reductase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0055129 L-proline biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PKK0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PKM6-1", "uniprot_id": [ { "id": "A0A1D5PKM6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PKM6", "type": "external" } ], "mass": 59722.0, "length": 539, "protein_name": "protein disulfide-isomerase", "gene_name": "PDIA2", "organism": "Chicken", "refseq_name": "protein disulfide-isomerase A2", "refseq_ac": [ { "id": "XP_015150100", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015150100", "type": "external" } ], "gene_names_uniprotkb": "PDIA2", "gene_names_refseq": "PDIA2", "protein_names_uniprotkb": "protein disulfide-isomerase; 5.3.4.1", "protein_names_refseq": "protein disulfide-isomerase A2", "tax_id": 9031, "disease": "", "pathway": " (gga:100857897)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052545.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015035 protein-disulfide reductase activity;GO:0016853 isomerase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PKM6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PKN1-1", "uniprot_id": [ { "id": "A0A1D5PKN1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PKN1", "type": "external" } ], "mass": 62138.0, "length": 551, "protein_name": "E3 ubiquitin-protein ligase TRIM8", "gene_name": "TRIM8", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase TRIM8", "refseq_ac": [ { "id": "NP_001026404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026404", "type": "external" } ], "gene_names_uniprotkb": "TRIM8", "gene_names_refseq": "TRIM8", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRIM8; 2.3.2.27; Glioblastoma-expressed RING finger protein; RING finger protein 27; RING-type E3 ubiquitin transferase TRIM8; Tripartite motif-containing protein 8", "protein_names_refseq": "E3 ubiquitin-protein ligase TRIM8; probable E3 ubiquitin-protein ligase TRIM8; tripartite motif-containing protein 8", "tax_id": 9031, "disease": "", "pathway": " (gga:423864)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719866.1, SRR13267658.2841.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000232.1. On Nov 18, 2021 this sequence version replaced NP_001026404.1., [RefSeq]; E3 ubiquitin-protein ligase that participates in multiple biological processes including cell survival, differentiation, apoptosis, and in particular, the innate immune response. Participates in the activation of interferon-gamma signaling by promoting proteasomal degradation of the repressor SOCS1. Plays a positive role in the TNFalpha and IL-1beta signaling pathways. Mechanistically, induces the 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 component leading to the activation of NF-kappa-B. Also modulates STAT3 activity through negative regulation of PIAS3, either by degradation of PIAS3 through the ubiquitin-proteasome pathway or exclusion of PIAS3 from the nucleus. Negatively regulates TLR3/4-mediated innate immune response by catalyzing 'Lys-6'- and 'Lys-33'-linked polyubiquitination of TICAM1 and thereby disrupting the TICAM1-TBK1 interaction., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016605 PML body;GO:0005634 nucleus", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0044790 suppression of viral release by host;GO:0045087 innate immune response;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0010508 positive regulation of autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PKN1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PKT3-1", "uniprot_id": [ { "id": "A0A1D5PKT3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PKT3", "type": "external" } ], "mass": 16418.0, "length": 146, "protein_name": "Translocase of outer mitochondrial membrane 20", "gene_name": "TOMM20", "organism": "Chicken", "refseq_name": "mitochondrial import receptor subunit TOM20 homolog", "refseq_ac": [ { "id": "XP_423972", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_423972", "type": "external" } ], "gene_names_uniprotkb": "TOMM20", "gene_names_refseq": "TOMM20", "protein_names_uniprotkb": "Translocase of outer mitochondrial membrane 20", "protein_names_refseq": "mitochondrial import receptor subunit TOM20 homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:426309); (R-GGA-5205685); (R-GGA-5689880)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_423972.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0015450 protein-transporting ATPase activity;GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site;GO:0071944 cell periphery;GO:0097225 sperm midpiece;GO:0005742 mitochondrial outer membrane translocase complex;GO:0140494 migrasome", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006626 protein targeting to mitochondrion;GO:0030150 protein import into mitochondrial matrix;GO:0016031 tRNA import into mitochondrion;GO:0006605 protein targeting", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PKT3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PKX3-1", "uniprot_id": [ { "id": "A0A1D5PKX3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PKX3", "type": "external" } ], "mass": 97601.0, "length": 873, "protein_name": "Zinc fingers and homeoboxes protein 1", "gene_name": "C2H8ORF76", "organism": "Chicken", "refseq_name": "zinc fingers and homeoboxes protein 1", "refseq_ac": [ { "id": "XP_040520729", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040520729", "type": "external" } ], "gene_names_uniprotkb": "C2H8ORF76", "gene_names_refseq": "C2H8ORF76", "protein_names_uniprotkb": "Zinc fingers and homeoboxes protein 1", "protein_names_refseq": "zinc fingers and homeoboxes protein 1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052574.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PKX3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PL02-1", "uniprot_id": [ { "id": "A0A1D5PL02_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PL02", "type": "external" } ], "mass": 45491.0, "length": 397, "protein_name": "DEP domain containing MTOR-interacting protein", "gene_name": "DEPTOR", "organism": "Chicken", "refseq_name": "DEP domain-containing mTOR-interacting protein", "refseq_ac": [ { "id": "NP_001186431", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186431", "type": "external" } ], "gene_names_uniprotkb": "DEPTOR", "gene_names_refseq": "DEPDC6; DEPTOR", "protein_names_uniprotkb": "DEP domain containing MTOR-interacting protein", "protein_names_refseq": "DEP domain containing 6; DEP domain-containing mTOR-interacting protein", "tax_id": 9031, "disease": "", "pathway": " (gga:420357)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267659.134306.1, SRR13267654.247121.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000044.1. On Dec 9, 2010 this sequence version replaced XP_418463.2. Sequence Note: This RefSeq record was created from transcripts from different strains and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0070300 phosphatidic acid binding;GO:0030291 protein serine/threonine kinase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0010508 positive regulation of autophagy;GO:2001236 regulation of extrinsic apoptotic signaling pathway;GO:0045792 negative regulation of cell size", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PL02-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PL43-1", "uniprot_id": [ { "id": "A0A1D5PL43_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PL43", "type": "external" } ], "mass": 26784.0, "length": 247, "protein_name": "GS homeobox 1", "gene_name": "GSX1", "organism": "Chicken", "refseq_name": "GS homeobox 1", "refseq_ac": [ { "id": "XP_015135226", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015135226", "type": "external" } ], "gene_names_uniprotkb": "GSX1", "gene_names_refseq": "GSX1", "protein_names_uniprotkb": "GS homeobox 1", "protein_names_refseq": "GS homeobox 1", "tax_id": 9031, "disease": "", "pathway": " (gga:107052208)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0007420 brain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PL43-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PL80-1", "uniprot_id": [ { "id": "A0A1D5PL80_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PL80", "type": "external" } ], "mass": 45729.0, "length": 410, "protein_name": "Sphingomyelin phosphodiesterase 2", "gene_name": "SMPD2", "organism": "Chicken", "refseq_name": "sphingomyelin phosphodiesterase 2 isoform X2", "refseq_ac": [ { "id": "XP_001232516", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001232516", "type": "external" } ], "gene_names_uniprotkb": "SMPD2", "gene_names_refseq": "SMPD2", "protein_names_uniprotkb": "Sphingomyelin phosphodiesterase 2; 3.1.4.12; Lyso-platelet-activating factor-phospholipase C; Neutral sphingomyelinase", "protein_names_refseq": "sphingomyelin phosphodiesterase 2 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:770663); (R-GGA-5626978); (R-GGA-9840310)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052557.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.12", "type": "external" }, { "id": "3.1.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.38", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004767 sphingomyelin phosphodiesterase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0071944 cell periphery;GO:0005901 caveola", "go_biological_process": "GO:0030149 sphingolipid catabolic process;GO:0046513 ceramide biosynthetic process;GO:0006685 sphingomyelin catabolic process;GO:0006684 sphingomyelin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PL80-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PLB7-1", "uniprot_id": [ { "id": "A0A1D5PLB7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PLB7", "type": "external" } ], "mass": 161305.0, "length": 1436, "protein_name": "Histone-lysine N-methyltransferase NSD3", "gene_name": "WHSC1L1", "organism": "Chicken", "refseq_name": "histone-lysine N-methyltransferase NSD3 isoform X2", "refseq_ac": [ { "id": "XP_046759362", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046759362", "type": "external" } ], "gene_names_uniprotkb": "WHSC1L1", "gene_names_refseq": "WHSC1L1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase NSD3; 2.1.1.370; 2.1.1.371; Nuclear SET domain-containing protein 3", "protein_names_refseq": "histone-lysine N-methyltransferase NSD3 isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052553.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.370", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.370", "type": "external" }, { "id": "2.1.1.371", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.371", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046975 histone H3K36 methyltransferase activity;GO:0140537 transcription regulator activator activity;GO:0140951 histone H3K27 trimethyltransferase activity;GO:0140946 histone H3K4 dimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PLB7-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PLC3-1", "uniprot_id": [ { "id": "A0A1D5PLC3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PLC3", "type": "external" } ], "mass": 54122.0, "length": 480, "protein_name": "Ataxin-10", "gene_name": "ATXN10", "organism": "Chicken", "refseq_name": "ataxin-10 isoform X1", "refseq_ac": [ { "id": "XP_416469", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_416469", "type": "external" } ], "gene_names_uniprotkb": "ATXN10", "gene_names_refseq": "ATXN10", "protein_names_uniprotkb": "Ataxin-10", "protein_names_refseq": "ataxin-10 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:418245)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_416469.1. COMPLETENESS: full length., [RefSeq]; May play a role in the regulation of cytokinesis. May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons. Does not appear to play a major role in ciliogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0048471 perinuclear region of cytoplasm;GO:0005814 centriole", "go_biological_process": "GO:0031175 neuron projection development;GO:0051301 cell division;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PLC3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PLZ8-1", "uniprot_id": [ { "id": "A0A1D5PLZ8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PLZ8", "type": "external" } ], "mass": 7874.0, "length": 69, "protein_name": "Guanine nucleotide-binding protein subunit gamma", "gene_name": "GNGT2", "organism": "Chicken", "refseq_name": "guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2", "refseq_ac": [ { "id": "NP_001289037", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289037", "type": "external" } ], "gene_names_uniprotkb": "GNGT2", "gene_names_refseq": "GNGT2", "protein_names_uniprotkb": "Guanine nucleotide-binding protein subunit gamma", "protein_names_refseq": "guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2", "tax_id": 9031, "disease": "", "pathway": " (gga:100859179); (R-GGA-1296041); (R-GGA-202040); (R-GGA-392170); (R-GGA-392451); (R-GGA-4086398); (R-GGA-416476); (R-GGA-416482); (R-GGA-418217); (R-GGA-418555); (R-GGA-418592); (R-GGA-418594); (R-GGA-418597); (R-GGA-428930); (R-GGA-456926); (R-GGA-500657); (R-GGA-6814122); (R-GGA-8964315); (R-GGA-8964616); (R-GGA-9009391); (R-GGA-9634597); (R-GGA-997272)", "pathway_count": 22, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: DR426530.1, DR427743.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000364.1. On Oct 1, 2014 this sequence version replaced XP_003642837.1., [RefSeq]; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0003924 GTPase activity", "go_cellular_component": "GO:0005834 heterotrimeric G-protein complex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PLZ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PM29-1", "uniprot_id": [ { "id": "A0A1D5PM29_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PM29", "type": "external" } ], "mass": 77263.0, "length": 701, "protein_name": "5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial", "gene_name": "MTO1", "organism": "Chicken", "refseq_name": "protein MTO1 homolog, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_015140235", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015140235", "type": "external" } ], "gene_names_uniprotkb": "MTO1", "gene_names_refseq": "MTO1", "protein_names_uniprotkb": "5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial; Mitochondrial tRNA translation optimization 1; Protein MTO1 homolog, mitochondrial", "protein_names_refseq": "protein MTO1 homolog, mitochondrial isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 1, 2022 this sequence version replaced XP_015140235.2. COMPLETENESS: full length., [RefSeq]; Component of the GTPBP3-MTO1 complex that catalyzes the 5-taurinomethyluridine (taum(5)U) modification at the 34th wobble position (U34) of mitochondrial tRNAs (mt-tRNAs), which plays a role in mt-tRNA decoding and mitochondrial translation. Taum(5)U formation on mammalian mt-tRNA requires the presence of both GTPBP3-mediated GTPase activity and MTO1 catalytic activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0160236 tRNA 5-taurinomethyluridine synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:7770010 GTPBP3-MTO1 complex", "go_biological_process": "GO:0030488 tRNA methylation;GO:0070899 mitochondrial tRNA wobble uridine modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PM29-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PMF5-1", "uniprot_id": [ { "id": "A0A1D5PMF5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PMF5", "type": "external" } ], "mass": 17106.0, "length": 151, "protein_name": "Complexin-3", "gene_name": "LOC769223", "organism": "Chicken", "refseq_name": "complexin-3-like", "refseq_ac": [ { "id": "XP_015155273", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015155273", "type": "external" } ], "gene_names_uniprotkb": "LOC769223", "gene_names_refseq": "LOC769223", "protein_names_uniprotkb": "Complexin-3", "protein_names_refseq": "complexin-3-like", "tax_id": 9031, "disease": "", "pathway": " (gga:769223)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052559.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0043195 terminal bouton;GO:0031201 SNARE complex", "go_biological_process": "GO:0050804 modulation of chemical synaptic transmission;GO:0031630 regulation of synaptic vesicle fusion to presynaptic active zone membrane;GO:0016079 synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PMF5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PMF8-1", "uniprot_id": [ { "id": "A0A1D5PMF8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PMF8", "type": "external" } ], "mass": 121520.0, "length": 1088, "protein_name": "Semaphorin-6D", "gene_name": "SEMA6D", "organism": "Chicken", "refseq_name": "semaphorin-6D isoform X1", "refseq_ac": [ { "id": "XP_015147424", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015147424", "type": "external" } ], "gene_names_uniprotkb": "SEMA6D", "gene_names_refseq": "SEMA6D", "protein_names_uniprotkb": "Semaphorin-6D", "protein_names_refseq": "semaphorin-6D isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052541.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration;GO:0007411 axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PMF8-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PMI2-1", "uniprot_id": [ { "id": "A0A1D5PMI2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI2", "type": "external" } ], "mass": 87412.0, "length": 796, "protein_name": "BCL11 transcription factor A", "gene_name": "BCL11A", "organism": "Chicken", "refseq_name": "BCL11 transcription factor A", "refseq_ac": [ { "id": "NP_001026202", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026202", "type": "external" } ], "gene_names_uniprotkb": "BCL11A", "gene_names_refseq": "BCL11A", "protein_names_uniprotkb": "BCL11 transcription factor A", "protein_names_refseq": "B-cell CLL/lymphoma 11A (zinc finger protein); B-cell lymphoma/leukemia 11A; BCL11 transcription factor A", "tax_id": 9031, "disease": "", "pathway": " (gga:421199); (R-GGA-9933946); (R-GGA-9934037)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851441.1, SRR13267659.69849.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05341171 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000059.1. On Sep 23, 2021 this sequence version replaced NP_001026202.1., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016514 SWI/SNF complex;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:2000171 negative regulation of dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PMI2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PMI7-1", "uniprot_id": [ { "id": "A0A1D5PMI7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PMI7", "type": "external" } ], "mass": 48929.0, "length": 429, "protein_name": "Zinc finger CCCH domain-containing protein 15", "gene_name": "ZC3H15", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ZC3H15", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 15", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:423992); (R-GGA-9629569)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PMI7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PMP7-1", "uniprot_id": [ { "id": "A0A1D5PMP7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PMP7", "type": "external" } ], "mass": 12121.0, "length": 112, "protein_name": "Tumor suppressor 2, mitochondrial calcium regulator", "gene_name": "TUSC2", "organism": "Chicken", "refseq_name": "tumor suppressor candidate 2 isoform X2", "refseq_ac": [ { "id": "XP_015148285", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015148285", "type": "external" } ], "gene_names_uniprotkb": "TUSC2", "gene_names_refseq": "TUSC2", "protein_names_uniprotkb": "Tumor suppressor 2, mitochondrial calcium regulator", "protein_names_refseq": "tumor suppressor candidate 2 isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052543.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006954 inflammatory response;GO:0051881 regulation of mitochondrial membrane potential", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PMP7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PMT7-1", "uniprot_id": [ { "id": "A0A1D5PMT7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PMT7", "type": "external" } ], "mass": 34210.0, "length": 316, "protein_name": "BarH like homeobox 1", "gene_name": "BARHL1", "organism": "Chicken", "refseq_name": "barH-like 1 homeobox protein", "refseq_ac": [ { "id": "XP_015135250", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015135250", "type": "external" } ], "gene_names_uniprotkb": "BARHL1", "gene_names_refseq": "BARHL1", "protein_names_uniprotkb": "BarH like homeobox 1", "protein_names_refseq": "barH-like 1 homeobox protein", "tax_id": 9031, "disease": "", "pathway": " (gga:429598)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052548.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PMT7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PMT8-1", "uniprot_id": [ { "id": "A0A1D5PMT8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PMT8", "type": "external" } ], "mass": 11842.0, "length": 115, "protein_name": "Large ribosomal subunit protein P2", "gene_name": "RPLP2", "organism": "Chicken", "refseq_name": "60S acidic ribosomal protein P2", "refseq_ac": [ { "id": "XP_424134", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_424134", "type": "external" } ], "gene_names_uniprotkb": "RPLP2", "gene_names_refseq": "RPLP2", "protein_names_uniprotkb": "Large ribosomal subunit protein P2; 60S acidic ribosomal protein P2", "protein_names_refseq": "60S acidic ribosomal protein P2", "tax_id": 9031, "disease": "", "pathway": " (gga:426492); (R-GGA-1799339); (R-GGA-72706); (R-GGA-975956); (R-GGA-975957); (R-GGA-9954709); (R-GGA-9954714); (R-GGA-9954716)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays an important role in the elongation step of protein synthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002182 cytoplasmic translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PMT8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PMY0-1", "uniprot_id": [ { "id": "A0A1D5PMY0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PMY0", "type": "external" } ], "mass": 28319.0, "length": 247, "protein_name": "F-box protein 2", "gene_name": "FBXO2", "organism": "Chicken", "refseq_name": "F-box only protein 2", "refseq_ac": [ { "id": "NP_001394715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001394715", "type": "external" } ], "gene_names_uniprotkb": "FBXO2", "gene_names_refseq": "FBXO2", "protein_names_uniprotkb": "F-box protein 2", "protein_names_refseq": "F-box only protein 2", "tax_id": 9031, "disease": "", "pathway": " (gga:419495); (R-GGA-8951664); (R-GGA-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000329.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031249 denatured protein binding;GO:0001540 amyloid-beta binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0043197 dendritic spine;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0036503 ERAD pathway;GO:0006516 glycoprotein catabolic process;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process;GO:0099576 regulation of protein catabolic process at postsynapse, modulating synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PMY0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PMZ4-1", "uniprot_id": [ { "id": "A0A1D5PMZ4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PMZ4", "type": "external" } ], "mass": 19747.0, "length": 173, "protein_name": "Protein tyrosine phosphatase type IVA 3", "gene_name": "PTP4A3", "organism": "Chicken", "refseq_name": "protein tyrosine phosphatase type IVA 3", "refseq_ac": [ { "id": "XP_004940124", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004940124", "type": "external" } ], "gene_names_uniprotkb": "PTP4A3", "gene_names_refseq": "PTP4A3", "protein_names_uniprotkb": "Protein tyrosine phosphatase type IVA 3; 3.1.3.48; Protein-tyrosine phosphatase 4a3", "protein_names_refseq": "protein tyrosine phosphatase type IVA 3", "tax_id": 9031, "disease": "", "pathway": " (gga:768713)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005768 endosome", "go_biological_process": "GO:0043542 endothelial cell migration;GO:0009966 regulation of signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PMZ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PN36-1", "uniprot_id": [ { "id": "A0A1D5PN36_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PN36", "type": "external" } ], "mass": 26548.0, "length": 248, "protein_name": "trypsin", "gene_name": "LOC107054567", "organism": "Chicken", "refseq_name": "trypsin II-P29", "refseq_ac": [ { "id": "XP_040507310", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040507310", "type": "external" } ], "gene_names_uniprotkb": "LOC107054567", "gene_names_refseq": "LOC107054567", "protein_names_uniprotkb": "trypsin; 3.4.21.4", "protein_names_refseq": "trypsin II-P29", "tax_id": 9031, "disease": "", "pathway": " (gga:107054568); (R-GGA-1592389); (R-GGA-6798695); (R-GGA-6803157)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "1.8.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2", "type": "external" }, { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "3.4.21.41", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.41", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.24.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "3.4.21.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.7", "type": "external" }, { "id": "3.4.21.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.1", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PN36-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PN41-1", "uniprot_id": [ { "id": "A0A1D5PN41_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PN41", "type": "external" } ], "mass": 23978.0, "length": 215, "protein_name": "Maleylacetoacetate isomerase", "gene_name": "GSTZ1", "organism": "Chicken", "refseq_name": "maleylacetoacetate isomerase isoform 2", "refseq_ac": [ { "id": "NP_001264398", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264398", "type": "external" } ], "gene_names_uniprotkb": "GSTZ1", "gene_names_refseq": "GSTZ1", "protein_names_uniprotkb": "Maleylacetoacetate isomerase; 2.5.1.18; 5.2.1.2; GSTZ1-1; Glutathione S-transferase zeta 1", "protein_names_refseq": "glutathione transferase zeta 1 (maleylacetoacetate isomerase); maleylacetoacetate isomerase isoform 2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-156590); (R-GGA-204174); (R-GGA-8963684)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01006603.1, HAEL01006795.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000215.1. Transcript Variant: This variant (2) has an alternate 5' exon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0016034 maleylacetoacetate isomerase activity;GO:0016740 transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PN41-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PN54-1", "uniprot_id": [ { "id": "A0A1D5PN54_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PN54", "type": "external" } ], "mass": 59899.0, "length": 553, "protein_name": "ATP synthase subunit alpha", "gene_name": "ATP5F1AZ", "organism": "Chicken", "refseq_name": "ATP synthase F(1) complex subunit alpha, mitochondrial", "refseq_ac": [ { "id": "NP_989617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_989617", "type": "external" } ], "gene_names_uniprotkb": "ATP5F1AZ", "gene_names_refseq": "ATP5A1Z; ATP5A1; ATP5F1AZ", "protein_names_uniprotkb": "ATP synthase subunit alpha", "protein_names_refseq": "ATP synthase F(1) complex subunit alpha, mitochondrial; ATP synthase alpha subunit; ATP synthase subunit alpha, mitochondrial; ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle", "tax_id": 9031, "disease": "", "pathway": " (gga:374159); (R-GGA-163210); (R-GGA-8949613); (R-GGA-9837999)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01000156.1, HAEK01011589.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000086.1. On Sep 23, 2021 this sequence version replaced NP_989617.2., [RefSeq]; Produces ATP from ADP in the presence of a proton gradient across the membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0043531 ADP binding;GO:0046933 proton-transporting ATP synthase activity, rotational mechanism", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045259 proton-transporting ATP synthase complex", "go_biological_process": "GO:0015986 proton motive force-driven ATP synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PN54-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PN79-1", "uniprot_id": [ { "id": "A0A1D5PN79_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PN79", "type": "external" } ], "mass": 56968.0, "length": 485, "protein_name": "Regulator of G-protein signaling 9", "gene_name": "RGS9", "organism": "Chicken", "refseq_name": "regulator of G-protein signaling 9 isoform X1", "refseq_ac": [ { "id": "XP_046758137", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046758137", "type": "external" } ], "gene_names_uniprotkb": "RGS9", "gene_names_refseq": "RGS9", "protein_names_uniprotkb": "Regulator of G-protein signaling 9", "protein_names_refseq": "regulator of G-protein signaling 9 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-418594); (R-GGA-6814122)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052549.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043005 neuron projection;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007212 G protein-coupled dopamine receptor signaling pathway;GO:0007601 visual perception;GO:0009968 negative regulation of signal transduction;GO:0008277 regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PN79-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PN84-1", "uniprot_id": [ { "id": "A0A1D5PN84_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PN84", "type": "external" } ], "mass": 13545.0, "length": 126, "protein_name": "Mitochondrial import inner membrane translocase subunit", "gene_name": "TIMM10B", "organism": "Chicken", "refseq_name": "mitochondrial import inner membrane translocase subunit Tim10 B", "refseq_ac": [ { "id": "XP_015136417", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015136417", "type": "external" } ], "gene_names_uniprotkb": "TIMM10B", "gene_names_refseq": "TIMM10B", "protein_names_uniprotkb": "Mitochondrial import inner membrane translocase subunit", "protein_names_refseq": "mitochondrial import inner membrane translocase subunit Tim10 B", "tax_id": 9031, "disease": "", "pathway": " (gga:107052461); (R-GGA-1268020)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0140318 protein transporter activity", "go_cellular_component": "GO:0042719 mitochondrial intermembrane space chaperone complex;GO:0005743 mitochondrial inner membrane;GO:0042721 TIM22 mitochondrial import inner membrane insertion complex", "go_biological_process": "GO:0015031 protein transport;GO:0045039 protein insertion into mitochondrial inner membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PN84-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PNB7-1", "uniprot_id": [ { "id": "A0A1D5PNB7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PNB7", "type": "external" } ], "mass": 50980.0, "length": 478, "protein_name": "Zic family member 2", "gene_name": "ZIC2", "organism": "Chicken", "refseq_name": "zinc finger protein ZIC 2", "refseq_ac": [ { "id": "XP_015130400", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015130400", "type": "external" } ], "gene_names_uniprotkb": "ZIC2", "gene_names_refseq": "ZIC2", "protein_names_uniprotkb": "Zic family member 2", "protein_names_refseq": "zinc finger protein ZIC 2", "tax_id": 9031, "disease": "", "pathway": " (gga:428021)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PNB7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PNC3-1", "uniprot_id": [ { "id": "A0A1D5PNC3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PNC3", "type": "external" } ], "mass": 49785.0, "length": 462, "protein_name": "Sodium-coupled neutral amino acid transporter 7", "gene_name": "SLC38A7", "organism": "Chicken", "refseq_name": "putative sodium-coupled neutral amino acid transporter 7", "refseq_ac": [ { "id": "XP_015134689", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015134689", "type": "external" } ], "gene_names_uniprotkb": "SLC38A7", "gene_names_refseq": "SLC38A7", "protein_names_uniprotkb": "Sodium-coupled neutral amino acid transporter 7; Solute carrier family 38 member 7", "protein_names_refseq": "putative sodium-coupled neutral amino acid transporter 7", "tax_id": 9031, "disease": "", "pathway": " (gga:107052162)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Symporter that selectively cotransports sodium ions and amino acids, such as L-glutamine and L-asparagine from the lysosome into the cytoplasm and may participates in mTORC1 activation. The transport activity requires an acidic lysosomal lumen., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015186 L-glutamine transmembrane transporter activity;GO:0015182 L-asparagine transmembrane transporter activity;GO:0140901 L-asparagine:sodium symporter activity;GO:0140902 L-glutamine:sodium symporter activity", "go_cellular_component": "GO:0030424 axon;GO:0005765 lysosomal membrane;GO:0016020 membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0006814 sodium ion transport;GO:0003333 amino acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PNC3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PND8-1", "uniprot_id": [ { "id": "A0A1D5PND8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PND8", "type": "external" } ], "mass": 60015.0, "length": 544, "protein_name": "alanine transaminase", "gene_name": "GPT2", "organism": "Chicken", "refseq_name": "alanine aminotransferase 2", "refseq_ac": [ { "id": "XP_015147909", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015147909", "type": "external" } ], "gene_names_uniprotkb": "GPT2", "gene_names_refseq": "GPT2", "protein_names_uniprotkb": "alanine transaminase; 2.6.1.2; Glutamate pyruvate transaminase 2; Glutamic--alanine transaminase 2; Glutamic--pyruvic transaminase 2", "protein_names_refseq": "alanine aminotransferase 2", "tax_id": 9031, "disease": "", "pathway": " (gga:415746); (R-GGA-8964540)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006103 2-oxoglutarate metabolic process;GO:0042851 L-alanine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PND8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PNJ4-1", "uniprot_id": [ { "id": "A0A1D5PNJ4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PNJ4", "type": "external" } ], "mass": 33229.0, "length": 298, "protein_name": "Glycerophosphodiester phosphodiesterase 1", "gene_name": "GDE1", "organism": "Chicken", "refseq_name": "glycerophosphodiester phosphodiesterase 1 isoform X2", "refseq_ac": [ { "id": "XP_015150034", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015150034", "type": "external" } ], "gene_names_uniprotkb": "GDE1", "gene_names_refseq": "GDE1", "protein_names_uniprotkb": "Glycerophosphodiester phosphodiesterase 1", "protein_names_refseq": "glycerophosphodiester phosphodiesterase 1 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6814848)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052545.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008889 glycerophosphodiester phosphodiesterase activity;GO:0047395 glycerophosphoinositol glycerophosphodiesterase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006580 ethanolamine metabolic process;GO:0070291 N-acylethanolamine metabolic process;GO:0006644 phospholipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PNJ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PNL3-1", "uniprot_id": [ { "id": "A0A1D5PNL3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PNL3", "type": "external" } ], "mass": 17138.0, "length": 152, "protein_name": "Ubiquitin conjugating enzyme E2 N", "gene_name": "UBE2N", "organism": "Chicken", "refseq_name": "ubiquitin-conjugating enzyme E2 N", "refseq_ac": [ { "id": "NP_001012828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012828", "type": "external" } ], "gene_names_uniprotkb": "UBE2N", "gene_names_refseq": "UBE2N", "protein_names_uniprotkb": "Ubiquitin conjugating enzyme E2 N", "protein_names_refseq": "ubiquitin-conjugating enzyme E2 N; ubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)", "tax_id": 9031, "disease": "", "pathway": " (gga:417898); (R-GGA-5693565); (R-GGA-5693571); (R-GGA-5693607); (R-GGA-5696395); (R-GGA-69473); (R-GGA-8866654); (R-GGA-983168)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "17349954", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851495.1, SRR13267654.183637.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992484 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1. On Sep 23, 2021 this sequence version replaced NP_001012828.1., [RefSeq]; These data reveal a critical and unexpected role for vertebrate Ubc13 in the initiation of homologous recombination at the level of double-strand break processing., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016740 transferase activity;GO:0061631 ubiquitin conjugating enzyme activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0070534 protein K63-linked ubiquitination;GO:0006301 DNA damage tolerance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5PNL3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PNM0-1", "uniprot_id": [ { "id": "A0A1D5PNM0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PNM0", "type": "external" } ], "mass": 21327.0, "length": 174, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "gene_name": "NDUFB9", "organism": "Chicken", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "refseq_ac": [ { "id": "XP_418444", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_418444", "type": "external" } ], "gene_names_uniprotkb": "NDUFB9", "gene_names_refseq": "NDUFB9", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9; Complex I-B22; NADH-ubiquinone oxidoreductase B22 subunit", "protein_names_refseq": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9", "tax_id": 9031, "disease": "", "pathway": " (gga:420337); (R-GGA-611105); (R-GGA-6799198)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_418444.2. COMPLETENESS: full length., [RefSeq]; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PNM0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PNR2-1", "uniprot_id": [ { "id": "A0A1D5PNR2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PNR2", "type": "external" } ], "mass": 64143.0, "length": 546, "protein_name": "5'-nucleotidase domain containing 3", "gene_name": "NT5DC3", "organism": "Chicken", "refseq_name": "5'-nucleotidase domain-containing protein 3", "refseq_ac": [ { "id": "XP_425487", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_425487", "type": "external" } ], "gene_names_uniprotkb": "NT5DC3", "gene_names_refseq": "NT5DC3", "protein_names_uniprotkb": "5'-nucleotidase domain containing 3", "protein_names_refseq": "5'-nucleotidase domain-containing protein 3", "tax_id": 9031, "disease": "", "pathway": " (gga:427914)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Jun 19, 2013 this sequence version replaced XP_425487.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008253 5'-nucleotidase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0043235 receptor complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PNR2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PP34-1", "uniprot_id": [ { "id": "A0A1D5PP34_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PP34", "type": "external" } ], "mass": 89578.0, "length": 787, "protein_name": "Exocyst complex component 7", "gene_name": "EXOC7", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EXOC7", "gene_names_refseq": "", "protein_names_uniprotkb": "Exocyst complex component 7; Exocyst complex component Exo70", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-264876); (R-GGA-5620916)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0030496 midbody;GO:0034451 centriolar satellite;GO:0000145 exocyst", "go_biological_process": "GO:2000535 regulation of entry of bacterium into host cell;GO:1903438 positive regulation of mitotic cytokinetic process;GO:0015031 protein transport;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PP34-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PP57-1", "uniprot_id": [ { "id": "A0A1D5PP57_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PP57", "type": "external" } ], "mass": 55636.0, "length": 503, "protein_name": "Vacuolar proton pump subunit B", "gene_name": "ATP6V1B2", "organism": "Chicken", "refseq_name": "V-type proton ATPase subunit B", "refseq_ac": [ { "id": "NP_001280170", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280170", "type": "external" } ], "gene_names_uniprotkb": "ATP6V1B2", "gene_names_refseq": "ATP6V1B2; ATP6V1B; VATB", "protein_names_uniprotkb": "Vacuolar proton pump subunit B; V-ATPase subunit B; Vacuolar proton pump subunit B", "protein_names_refseq": "ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B; V-ATPase subunit B; V-type proton ATPase subunit B; Vacuolar proton pump subunit B; vacuolar H+-ATPase B subunit; vacuolar H-ATPase B subunit osteoclast isozyme", "tax_id": 9031, "disease": "", "pathway": " (gga:395497); (R-GGA-1222556); (R-GGA-77387); (R-GGA-917977); (R-GGA-9639288)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U61724.1, SRR13267659.117801.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000332.1. On Jun 5, 2014 this sequence version replaced XP_424534.3., [RefSeq]; Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0042470 melanosome;GO:0030665 clathrin-coated vesicle membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0046034 ATP metabolic process;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PP57-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PPF8-1", "uniprot_id": [ { "id": "A0A1D5PPF8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PPF8", "type": "external" } ], "mass": 94240.0, "length": 840, "protein_name": "Heat shock 70 kDa protein 4", "gene_name": "HSPA4", "organism": "Chicken", "refseq_name": "heat shock 70 kDa protein 4", "refseq_ac": [ { "id": "XP_414655", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_414655", "type": "external" } ], "gene_names_uniprotkb": "HSPA4", "gene_names_refseq": "HSPA4", "protein_names_uniprotkb": "Heat shock 70 kDa protein 4", "protein_names_refseq": "heat shock 70 kDa protein 4", "tax_id": 9031, "disease": "", "pathway": " (gga:416339)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_414655.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0070062 extracellular exosome", "go_biological_process": "GO:0006457 protein folding;GO:0051131 chaperone-mediated protein complex assembly;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PPF8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PPH1-1", "uniprot_id": [ { "id": "A0A1D5PPH1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PPH1", "type": "external" } ], "mass": 36735.0, "length": 330, "protein_name": "Neurogenic differentiation factor", "gene_name": "NEUROD4", "organism": "Chicken", "refseq_name": "neurogenic differentiation factor 4 isoform X1", "refseq_ac": [ { "id": "XP_015155714", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015155714", "type": "external" } ], "gene_names_uniprotkb": "NEUROD4", "gene_names_refseq": "NEUROD4", "protein_names_uniprotkb": "Neurogenic differentiation factor", "protein_names_refseq": "neurogenic differentiation factor 4 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052565.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0061564 axon development;GO:0043010 camera-type eye development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PPH1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PPI5-1", "uniprot_id": [ { "id": "A0A1D5PPI5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PPI5", "type": "external" } ], "mass": 32719.0, "length": 296, "protein_name": "NmrA-like family domain-containing protein 1", "gene_name": "NMRAL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NMRAL1", "gene_names_refseq": "", "protein_names_uniprotkb": "NmrA-like family domain-containing protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:416672); (R-GGA-70635)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PPI5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PPW2-1", "uniprot_id": [ { "id": "A0A1D5PPW2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PPW2", "type": "external" } ], "mass": 92142.0, "length": 824, "protein_name": "Prominin 2", "gene_name": "PROM2", "organism": "Chicken", "refseq_name": "prominin-2", "refseq_ac": [ { "id": "XP_015152815", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015152815", "type": "external" } ], "gene_names_uniprotkb": "PROM2", "gene_names_refseq": "PROM2", "protein_names_uniprotkb": "Prominin 2", "protein_names_refseq": "prominin-2", "tax_id": 9031, "disease": "", "pathway": " (gga:428200)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052553.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0016324 apical plasma membrane;GO:0005902 microvillus;GO:0031528 microvillus membrane;GO:0071914 prominosome", "go_biological_process": "GO:0048550 negative regulation of pinocytosis;GO:0032528 microvillus organization;GO:0031346 positive regulation of cell projection organization;GO:2001287 negative regulation of caveolin-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PPW2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PPW3-1", "uniprot_id": [ { "id": "A0A1D5PPW3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PPW3", "type": "external" } ], "mass": 123323.0, "length": 1111, "protein_name": "Solute carrier family 12 member 5", "gene_name": "SLC12A5", "organism": "Chicken", "refseq_name": "solute carrier family 12 member 5 isoform X2", "refseq_ac": [ { "id": "XP_024998055", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024998055", "type": "external" } ], "gene_names_uniprotkb": "SLC12A5", "gene_names_refseq": "SLC12A5", "protein_names_uniprotkb": "Solute carrier family 12 member 5", "protein_names_refseq": "solute carrier family 12 member 5 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-426117)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052551.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015379 potassium:chloride symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043005 neuron projection;GO:0099634 postsynaptic specialization membrane", "go_biological_process": "GO:0030644 intracellular chloride ion homeostasis;GO:0007268 chemical synaptic transmission;GO:0006884 cell volume homeostasis;GO:0060996 dendritic spine development;GO:1902476 chloride transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PPW3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PPX8-1", "uniprot_id": [ { "id": "A0A1D5PPX8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PPX8", "type": "external" } ], "mass": 87396.0, "length": 775, "protein_name": "Microprocessor complex subunit DGCR8", "gene_name": "DGCR8", "organism": "Chicken", "refseq_name": "microprocessor complex subunit DGCR8", "refseq_ac": [ { "id": "NP_001376382", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376382", "type": "external" } ], "gene_names_uniprotkb": "DGCR8", "gene_names_refseq": "DGCR8", "protein_names_uniprotkb": "Microprocessor complex subunit DGCR8", "protein_names_refseq": "DiGeorge syndrome critical region gene 8; microprocessor complex subunit DGCR8", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.218886.1, SRR13267659.9022.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000260.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0003725 double-stranded RNA binding;GO:0020037 heme binding;GO:0070878 primary miRNA binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0016604 nuclear body", "go_biological_process": "GO:0006974 DNA damage response;GO:0031053 primary miRNA processing;GO:2000633 positive regulation of pre-miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PPX8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PQ41-1", "uniprot_id": [ { "id": "A0A1D5PQ41_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PQ41", "type": "external" } ], "mass": 22950.0, "length": 214, "protein_name": "Claudin", "gene_name": "CLDN9", "organism": "Chicken", "refseq_name": "claudin-3", "refseq_ac": [ { "id": "XP_004946474", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004946474", "type": "external" } ], "gene_names_uniprotkb": "CLDN9", "gene_names_refseq": "CLDN9", "protein_names_uniprotkb": "Claudin", "protein_names_refseq": "claudin-3", "tax_id": 9031, "disease": "", "pathway": " (gga:417474)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052550.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0070293 renal absorption;GO:0160184 paracellular transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PQ41-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PQ44-1", "uniprot_id": [ { "id": "A0A1D5PQ44_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PQ44", "type": "external" } ], "mass": 149009.0, "length": 1422, "protein_name": "B-cell CLL/lymphoma 9 protein", "gene_name": "BCL9", "organism": "Chicken", "refseq_name": "B-cell CLL/lymphoma 9 protein isoform X1", "refseq_ac": [ { "id": "XP_015153750", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015153750", "type": "external" } ], "gene_names_uniprotkb": "BCL9", "gene_names_refseq": "BCL9", "protein_names_uniprotkb": "B-cell CLL/lymphoma 9 protein", "protein_names_refseq": "B-cell CLL/lymphoma 9 protein isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:418456); (R-GGA-201722)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005801 cis-Golgi network;GO:1990907 beta-catenin-TCF complex", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0060070 canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PQ44-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PQ46-1", "uniprot_id": [ { "id": "A0A1D5PQ46_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PQ46", "type": "external" } ], "mass": 83243.0, "length": 760, "protein_name": "Kin of IRRE-like protein 1", "gene_name": "KIRREL1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KIRREL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Kin of IRRE-like protein 1; Kin of irregular chiasm-like protein 1; Nephrin-like protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-373753)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0017022 myosin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0003094 glomerular filtration;GO:0045217 cell-cell junction maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PQ46-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PQ66-1", "uniprot_id": [ { "id": "A0A1D5PQ66_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PQ66", "type": "external" } ], "mass": 104869.0, "length": 911, "protein_name": "RNA binding motif protein 10", "gene_name": "RBM10", "organism": "Chicken", "refseq_name": "RNA-binding protein 5", "refseq_ac": [ { "id": "NP_001012798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012798", "type": "external" } ], "gene_names_uniprotkb": "RBM10", "gene_names_refseq": "RBM10; RBM5", "protein_names_uniprotkb": "RNA binding motif protein 10", "protein_names_refseq": "RNA binding motif protein 5; RNA-binding protein 5", "tax_id": 9031, "disease": "", "pathway": " (gga:415947); (R-GGA-9770562)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851628.1, SRR13267661.29216.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000252.1. On or before Dec 17, 2020 this sequence version replaced XP_025010228.1, NP_001012798.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:0000381 regulation of alternative mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PQ66-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PQ69-1", "uniprot_id": [ { "id": "A0A1D5PQ69_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PQ69", "type": "external" } ], "mass": 33401.0, "length": 293, "protein_name": "Uncharacterized protein", "gene_name": "LOC107049174", "organism": "Chicken", "refseq_name": "Golgi phosphoprotein 3", "refseq_ac": [ { "id": "XP_015155918", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015155918", "type": "external" } ], "gene_names_uniprotkb": "LOC107049174", "gene_names_refseq": "LOC107049174", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "Golgi phosphoprotein 3", "tax_id": 9031, "disease": "", "pathway": " (gga:107049174)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052571.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0032580 Golgi cisterna membrane;GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0031985 Golgi cisterna", "go_biological_process": "GO:0043001 Golgi to plasma membrane protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0007030 Golgi organization;GO:0048194 Golgi vesicle budding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PQ69-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PQ74-1", "uniprot_id": [ { "id": "A0A1D5PQ74_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PQ74", "type": "external" } ], "mass": 64280.0, "length": 582, "protein_name": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase", "gene_name": "DCP1A", "organism": "Chicken", "refseq_name": "mRNA-decapping enzyme 1A isoform X2", "refseq_ac": [ { "id": "XP_004944624", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004944624", "type": "external" } ], "gene_names_uniprotkb": "DCP1A", "gene_names_refseq": "DCP1A", "protein_names_uniprotkb": "5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase; 3.6.1.62", "protein_names_refseq": "mRNA-decapping enzyme 1A isoform X2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-430039); (R-GGA-450385)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052543.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding;GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0005737 cytoplasm", "go_biological_process": "GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA;GO:1903608 protein localization to cytoplasmic stress granule;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PQ74-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PQE8-1", "uniprot_id": [ { "id": "A0A1D5PQE8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PQE8", "type": "external" } ], "mass": 43776.0, "length": 377, "protein_name": "G protein subunit alpha 13", "gene_name": "GNA13", "organism": "Chicken", "refseq_name": "guanine nucleotide-binding protein subunit alpha-13", "refseq_ac": [ { "id": "XP_415686", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_415686", "type": "external" } ], "gene_names_uniprotkb": "GNA13", "gene_names_refseq": "GNA13", "protein_names_uniprotkb": "G protein subunit alpha 13", "protein_names_refseq": "guanine nucleotide-binding protein subunit alpha-13", "tax_id": 9031, "disease": "", "pathway": " (gga:417434); (R-GGA-193648); (R-GGA-416482); (R-GGA-428930); (R-GGA-456926); (R-GGA-9013148); (R-GGA-9013149)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052549.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031752 D5 dopamine receptor binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031683 G-protein beta/gamma-subunit complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0098794 postsynapse;GO:0031526 brush border membrane", "go_biological_process": "GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0008217 regulation of blood pressure;GO:0007266 Rho protein signal transduction;GO:0150052 regulation of postsynapse assembly;GO:0160221 Rho-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PQE8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PQF9-1", "uniprot_id": [ { "id": "A0A1D5PQF9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PQF9", "type": "external" } ], "mass": 59028.0, "length": 540, "protein_name": "ADP-ribosylation factor GTPase-activating protein 2", "gene_name": "ARFGAP2", "organism": "Chicken", "refseq_name": "ADP-ribosylation factor GTPase-activating protein 2 isoform X1", "refseq_ac": [ { "id": "XP_015142514", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015142514", "type": "external" } ], "gene_names_uniprotkb": "ARFGAP2", "gene_names_refseq": "ARFGAP2; ZNF289", "protein_names_uniprotkb": "ADP-ribosylation factor GTPase-activating protein 2; Zinc finger protein 289", "protein_names_refseq": "ADP-ribosylation factor GTPase-activating protein 2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:423187); (R-GGA-6807878); (R-GGA-6811434)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0048205 COPI coating of Golgi vesicle;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PQF9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PQM4-1", "uniprot_id": [ { "id": "A0A1D5PQM4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PQM4", "type": "external" } ], "mass": 21220.0, "length": 185, "protein_name": "DNA replication complex GINS protein PSF2", "gene_name": "GINS2", "organism": "Chicken", "refseq_name": "DNA replication complex GINS protein PSF2 isoform X1", "refseq_ac": [ { "id": "XP_414187", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_414187", "type": "external" } ], "gene_names_uniprotkb": "GINS2", "gene_names_refseq": "GINS2", "protein_names_uniprotkb": "DNA replication complex GINS protein PSF2", "protein_names_refseq": "DNA replication complex GINS protein PSF2 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_414187.2. COMPLETENESS: full length., [RefSeq]; Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000811 GINS complex;GO:0071162 CMG complex", "go_biological_process": "GO:0006260 DNA replication;GO:0000727 double-strand break repair via break-induced replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PQM4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PQZ6-1", "uniprot_id": [ { "id": "A0A1D5PQZ6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PQZ6", "type": "external" } ], "mass": 11100.0, "length": 103, "protein_name": "Potassium voltage-gated channel subfamily E regulatory subunit 5", "gene_name": "KCNE5", "organism": "Chicken", "refseq_name": "potassium voltage-gated channel subfamily E regulatory beta subunit 5", "refseq_ac": [ { "id": "XP_025005732", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_025005732", "type": "external" } ], "gene_names_uniprotkb": "KCNE5", "gene_names_refseq": "KCNE5", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily E regulatory subunit 5", "protein_names_refseq": "potassium voltage-gated channel subfamily E regulatory beta subunit 5", "tax_id": 9031, "disease": "", "pathway": " (gga:100858624); (R-GGA-5576890)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 100% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0086011 membrane repolarization during action potential;GO:0098915 membrane repolarization during ventricular cardiac muscle cell action potential;GO:1903765 negative regulation of potassium ion export across plasma membrane;GO:0086091 regulation of heart rate by cardiac conduction;GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PQZ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PR23-1", "uniprot_id": [ { "id": "A0A1D5PR23_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PR23", "type": "external" } ], "mass": 79605.0, "length": 728, "protein_name": "Epithelial splicing regulatory protein 2", "gene_name": "ESRP2", "organism": "Chicken", "refseq_name": "epithelial splicing regulatory protein 2 isoform X1", "refseq_ac": [ { "id": "XP_015147838", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015147838", "type": "external" } ], "gene_names_uniprotkb": "ESRP2", "gene_names_refseq": "ESRP2; RBM35B", "protein_names_uniprotkb": "Epithelial splicing regulatory protein 2; RNA-binding motif protein 35B; RNA-binding protein 35B", "protein_names_refseq": "epithelial splicing regulatory protein 2 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:1990904 ribonucleoprotein complex;GO:0005634 nucleus", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0043484 regulation of RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PR23-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PR34-1", "uniprot_id": [ { "id": "A0A1D5PR34_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PR34", "type": "external" } ], "mass": 17447.0, "length": 153, "protein_name": "ORM1-like protein", "gene_name": "ORMDL1", "organism": "Chicken", "refseq_name": "ORM1-like protein 1", "refseq_ac": [ { "id": "XP_001231893", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001231893", "type": "external" } ], "gene_names_uniprotkb": "ORMDL1", "gene_names_refseq": "ORMDL1", "protein_names_uniprotkb": "ORM1-like protein", "protein_names_refseq": "ORM1-like protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:423981); (R-GGA-1660661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 3% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0017059 serine palmitoyltransferase complex;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:2000303 regulation of ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process;GO:0006672 ceramide metabolic process;GO:0090156 intracellular sphingolipid homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PR34-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PR40-1", "uniprot_id": [ { "id": "A0A1D5PR40_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PR40", "type": "external" } ], "mass": 21397.0, "length": 184, "protein_name": "Large ribosomal subunit protein uL22", "gene_name": "LOC107049046", "organism": "Chicken", "refseq_name": "60S ribosomal protein L17 isoform X2", "refseq_ac": [ { "id": "XP_025000375", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_025000375", "type": "external" } ], "gene_names_uniprotkb": "LOC107049046", "gene_names_refseq": "LOC107049046", "protein_names_uniprotkb": "Large ribosomal subunit protein uL22; 60S ribosomal protein L17", "protein_names_refseq": "60S ribosomal protein L17 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:107049046); (gga:426845); (R-GGA-1799339); (R-GGA-72706); (R-GGA-975956); (R-GGA-975957); (R-GGA-9954709); (R-GGA-9954714); (R-GGA-9954716)", "pathway_count": 9, "publication_count": 1, "publication_id_list": "38395592", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052571.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit;GO:0022626 cytosolic ribosome;GO:0015934 large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5PR40-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PRB6-1", "uniprot_id": [ { "id": "A0A1D5PRB6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PRB6", "type": "external" } ], "mass": 10906.0, "length": 96, "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial", "gene_name": "NDUFB2", "organism": "Chicken", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial", "refseq_ac": [ { "id": "NP_001264825", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264825", "type": "external" } ], "gene_names_uniprotkb": "NDUFB2", "gene_names_refseq": "NDUFB2", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial; Complex I-AGGG; NADH-ubiquinone oxidoreductase AGGG subunit", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (gga:418118); (R-GGA-611105); (R-GGA-6799198)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU468726.1, CR353359.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN227462.1, BU441306.1, BU289042.1, BU230278.1 and CN227063.1. On Apr 27, 2013 this sequence version replaced XP_416351.1. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PRB6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PRH3-1", "uniprot_id": [ { "id": "A0A1D5PRH3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PRH3", "type": "external" } ], "mass": 44650.0, "length": 405, "protein_name": "Growth factor independent 1 transcriptional repressor", "gene_name": "GFI1", "organism": "Chicken", "refseq_name": "zinc finger protein Gfi-1", "refseq_ac": [ { "id": "XP_040534158", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040534158", "type": "external" } ], "gene_names_uniprotkb": "GFI1", "gene_names_refseq": "GFI1", "protein_names_uniprotkb": "Growth factor independent 1 transcriptional repressor", "protein_names_refseq": "zinc finger protein Gfi-1", "tax_id": 9031, "disease": "", "pathway": " (gga:429088)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052580.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0017053 transcription repressor complex;GO:0016604 nuclear body;GO:0016363 nuclear matrix", "go_biological_process": "GO:0070105 positive regulation of interleukin-6-mediated signaling pathway;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0034121 regulation of toll-like receptor signaling pathway;GO:0010977 negative regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PRH3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PS29-1", "uniprot_id": [ { "id": "A0A1D5PS29_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PS29", "type": "external" } ], "mass": 95360.0, "length": 858, "protein_name": "Elongation factor 2", "gene_name": "EEF2", "organism": "Chicken", "refseq_name": "elongation factor 2", "refseq_ac": [ { "id": "NP_990699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990699", "type": "external" } ], "gene_names_uniprotkb": "EEF2", "gene_names_refseq": "EEF2", "protein_names_uniprotkb": "Elongation factor 2", "protein_names_refseq": "EF-2; elongation factor 2", "tax_id": 9031, "disease": "", "pathway": " (gga:396325); (R-GGA-156902); (R-GGA-5358493); (R-GGA-6798695); (R-GGA-8876725)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "17118580;18222016;22987813;23008267", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: U46663.1, SRR12888519.75786.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000375.1. On Nov 5, 2021 this sequence version replaced NP_990699.1., [RefSeq]; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; EF-2 gene promoter is localized to the region -86 and +102 of the 5'-non-coding and upstream flanking region., [RefSeq, PubMed]; Glutamate receptors regulate eukaryotic elongation factor-2 kinase phosphorylation through the involvement of Ca2+/calmodulin/extracellular-regulated protein kinases 1/2., [RefSeq, PubMed]; These findings suggest that an eEF2 phosphorylation state localized to the growth cone regulates neurite outgrowth, [RefSeq, PubMed]; This study demonstrated that a reduced level of p-eEF2 is not responsible for immediate responses of a neuron to compromised afferent input but may impair the neuron's ability to initiate recovery signaling for survival., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity;GO:0019901 protein kinase binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0005840 ribosome", "go_biological_process": "GO:0045727 positive regulation of translation;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "A0A1D5PS29-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PS82-1", "uniprot_id": [ { "id": "A0A1D5PS82_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PS82", "type": "external" } ], "mass": 10004.0, "length": 98, "protein_name": "Keratin", "gene_name": "LOC121110032", "organism": "Chicken", "refseq_name": "feather keratin 1-like isoform X2", "refseq_ac": [ { "id": "XP_040521196", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040521196", "type": "external" } ], "gene_names_uniprotkb": "LOC121110032", "gene_names_refseq": "LOC121110032", "protein_names_uniprotkb": "Keratin", "protein_names_refseq": "feather keratin 1-like isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:107052805)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052574.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PS82-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PSE4-1", "uniprot_id": [ { "id": "A0A1D5PSE4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PSE4", "type": "external" } ], "mass": 50619.0, "length": 467, "protein_name": "Iroquois homeobox 1", "gene_name": "IRX1", "organism": "Chicken", "refseq_name": "iroquois-class homeodomain protein IRX-1", "refseq_ac": [ { "id": "NP_001025509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025509", "type": "external" } ], "gene_names_uniprotkb": "IRX1", "gene_names_refseq": "IRX1", "protein_names_uniprotkb": "Iroquois homeobox 1", "protein_names_refseq": "iroquois homeobox protein 1; iroquois homologue-1; iroquois-class homeodomain protein IRX-1", "tax_id": 9031, "disease": "", "pathway": " (gga:374185)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "25372603", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ238354.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992393, SAMEA103992428 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000042.1. On Sep 23, 2021 this sequence version replaced NP_001025509.1., [RefSeq]; A novel gain-of-function mutation of the proneural IRX1 and IRX2 genes disrupts axis elongation in the Araucana rumpless chicken. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0072086 specification of loop of Henle identity;GO:0072272 proximal/distal pattern formation involved in metanephric nephron development;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation;GO:0048468 cell development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1D5PSE4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PSK2-1", "uniprot_id": [ { "id": "A0A1D5PSK2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PSK2", "type": "external" } ], "mass": 73899.0, "length": 652, "protein_name": "Rho GTPase-activating protein 18", "gene_name": "ARHGAP18", "organism": "Chicken", "refseq_name": "rho GTPase-activating protein 18 isoform X1", "refseq_ac": [ { "id": "XP_419743", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_419743", "type": "external" } ], "gene_names_uniprotkb": "ARHGAP18", "gene_names_refseq": "ARHGAP18", "protein_names_uniprotkb": "Rho GTPase-activating protein 18; Rho-type GTPase-activating protein 18", "protein_names_refseq": "rho GTPase-activating protein 18 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-8980692); (R-GGA-9013106)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_419743.2. COMPLETENESS: full length., [RefSeq]; Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1. Regulates cell shape, spreading, and migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0001726 ruffle;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:2000145 regulation of cell motility;GO:0007264 small GTPase-mediated signal transduction;GO:0008360 regulation of cell shape;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PSK2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PSK7-1", "uniprot_id": [ { "id": "A0A1D5PSK7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PSK7", "type": "external" } ], "mass": 12360.0, "length": 121, "protein_name": "Keratin", "gene_name": "LOC121107563", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC121107563; LOC100857297", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:100859616)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005882 intermediate filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PSK7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PT13-1", "uniprot_id": [ { "id": "A0A1D5PT13_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PT13", "type": "external" } ], "mass": 32394.0, "length": 294, "protein_name": "cAMP-responsive element modulator", "gene_name": "CREM", "organism": "Chicken", "refseq_name": "cAMP-responsive element modulator isoform X1", "refseq_ac": [ { "id": "XP_015136748", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015136748", "type": "external" } ], "gene_names_uniprotkb": "CREM", "gene_names_refseq": "CREM; ICER", "protein_names_uniprotkb": "cAMP-responsive element modulator", "protein_names_refseq": "cAMP-responsive element modulator isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:1990589 ATF4-CREB1 transcription factor complex;GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0141156 cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PT13-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PTJ5-1", "uniprot_id": [ { "id": "A0A1D5PTJ5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PTJ5", "type": "external" } ], "mass": 32022.0, "length": 284, "protein_name": "Checkpoint protein", "gene_name": "HUS1", "organism": "Chicken", "refseq_name": "checkpoint protein HUS1 isoform X1", "refseq_ac": [ { "id": "XP_426029", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_426029", "type": "external" } ], "gene_names_uniprotkb": "HUS1", "gene_names_refseq": "HUS1", "protein_names_uniprotkb": "Checkpoint protein", "protein_names_refseq": "checkpoint protein HUS1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-176187); (R-GGA-5685938); (R-GGA-5693607)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_426029.2. COMPLETENESS: full length., [RefSeq]; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0035861 site of double-strand break;GO:0030896 checkpoint clamp complex", "go_biological_process": "GO:0000723 telomere maintenance;GO:0000724 double-strand break repair via homologous recombination;GO:0009314 response to radiation;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PTJ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PTM1-1", "uniprot_id": [ { "id": "A0A1D5PTM1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PTM1", "type": "external" } ], "mass": 69169.0, "length": 626, "protein_name": "Insulin like growth factor 2 mRNA binding protein 3", "gene_name": "IGF2BP3", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IGF2BP3", "gene_names_refseq": "", "protein_names_uniprotkb": "Insulin like growth factor 2 mRNA binding protein 3", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0048027 mRNA 5'-UTR binding;GO:1990247 N6-methyladenosine-containing RNA reader activity;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0070934 CRD-mediated mRNA stabilization;GO:0006417 regulation of translation;GO:0007399 nervous system development;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PTM1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PTQ4-1", "uniprot_id": [ { "id": "A0A1D5PTQ4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PTQ4", "type": "external" } ], "mass": 36584.0, "length": 320, "protein_name": "Protein phosphatase 1 regulatory subunit 42", "gene_name": "PPP1R42", "organism": "Chicken", "refseq_name": "protein phosphatase 1 regulatory subunit 42 isoform X1", "refseq_ac": [ { "id": "XP_025003756", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_025003756", "type": "external" } ], "gene_names_uniprotkb": "PPP1R42", "gene_names_refseq": "PPP1R42", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 42", "protein_names_refseq": "protein phosphatase 1 regulatory subunit 42 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:420168)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0070840 dynein complex binding;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0015630 microtubule cytoskeleton;GO:0002177 manchette", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PTQ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PTT4-1", "uniprot_id": [ { "id": "A0A1D5PTT4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PTT4", "type": "external" } ], "mass": 40270.0, "length": 340, "protein_name": "Carbohydrate sulfotransferase", "gene_name": "CHST13", "organism": "Chicken", "refseq_name": "carbohydrate sulfotransferase 13 isoform X1", "refseq_ac": [ { "id": "XP_004944659", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004944659", "type": "external" } ], "gene_names_uniprotkb": "CHST13", "gene_names_refseq": "CHST13", "protein_names_uniprotkb": "Carbohydrate sulfotransferase; 2.8.2.-", "protein_names_refseq": "carbohydrate sulfotransferase 13 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2022870)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052543.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.8.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-", "type": "external" } ], "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0001537 dermatan 4-sulfotransferase activity;GO:0047756 chondroitin 4-sulfotransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0016051 carbohydrate biosynthetic process;GO:0050650 chondroitin sulfate proteoglycan biosynthetic process;GO:0030166 proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PTT4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PTV1-1", "uniprot_id": [ { "id": "A0A1D5PTV1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PTV1", "type": "external" } ], "mass": 84310.0, "length": 761, "protein_name": "Amine oxidase", "gene_name": "AOC3", "organism": "Chicken", "refseq_name": "membrane primary amine oxidase isoform X1", "refseq_ac": [ { "id": "XP_040509312", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040509312", "type": "external" } ], "gene_names_uniprotkb": "AOC3", "gene_names_refseq": "AOC3", "protein_names_uniprotkb": "Amine oxidase; 1.4.3.-", "protein_names_refseq": "membrane primary amine oxidase isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-211945)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052558.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" } ], "go_molecular_function": "GO:0005507 copper ion binding;GO:0008131 primary methylamine oxidase activity;GO:0048038 quinone binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0009308 amine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PTV1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PTZ6-1", "uniprot_id": [ { "id": "A0A1D5PTZ6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PTZ6", "type": "external" } ], "mass": 90067.0, "length": 789, "protein_name": "[histone H3]-lysine(27) N-trimethyltransferase", "gene_name": "EZH1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EZH1", "gene_names_refseq": "", "protein_names_uniprotkb": "[histone H3]-lysine(27) N-trimethyltransferase; 2.1.1.356", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:420023); (R-GGA-212300)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0031491 nucleosome binding;GO:0046976 histone H3K27 methyltransferase activity;GO:0140693 molecular condensate scaffold activity;GO:0140951 histone H3K27 trimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032259 methylation;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PTZ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PU60-1", "uniprot_id": [ { "id": "A0A1D5PU60_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PU60", "type": "external" } ], "mass": 43817.0, "length": 389, "protein_name": "Chloride intracellular channel protein", "gene_name": "CLIC5", "organism": "Chicken", "refseq_name": "chloride intracellular channel protein 5 isoform X2", "refseq_ac": [ { "id": "XP_420060", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_420060", "type": "external" } ], "gene_names_uniprotkb": "CLIC5", "gene_names_refseq": "CLIC5", "protein_names_uniprotkb": "Chloride intracellular channel protein", "protein_names_refseq": "chloride intracellular channel protein 5 isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_420060.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0034707 chloride channel complex", "go_biological_process": "GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PU60-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PU93-1", "uniprot_id": [ { "id": "A0A1D5PU93_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PU93", "type": "external" } ], "mass": 64643.0, "length": 568, "protein_name": "FERM domain-containing protein 5", "gene_name": "FRMD5", "organism": "Chicken", "refseq_name": "FERM domain-containing protein 5 isoform X1", "refseq_ac": [ { "id": "XP_413944", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_413944", "type": "external" } ], "gene_names_uniprotkb": "FRMD5", "gene_names_refseq": "FRMD5", "protein_names_uniprotkb": "FERM domain-containing protein 5", "protein_names_refseq": "FERM domain-containing protein 5 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052541.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_413944.2. COMPLETENESS: full length., [RefSeq]; May be involved in regulation of cell migration. May regulate cell-matrix interactions via its interaction with ITGB5 and modifying ITGB5 cytoplasmic tail interactions such as with FERMT2 and TLN1. May regulate ROCK1 kinase activity possibly involved in regulation of actin stress fiber formation., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0008092 cytoskeletal protein binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005912 adherens junction", "go_biological_process": "GO:0045785 positive regulation of cell adhesion;GO:0031032 actomyosin structure organization;GO:0030334 regulation of cell migration;GO:2000146 negative regulation of cell motility", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PU93-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PUL6-1", "uniprot_id": [ { "id": "A0A1D5PUL6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PUL6", "type": "external" } ], "mass": 84119.0, "length": 728, "protein_name": "Heat shock protein 90 alpha family class A member 1", "gene_name": "HSP90AA1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HSP90AA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Heat shock protein 90 alpha family class A member 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:423463); (R-GGA-1227986); (R-GGA-2029482); (R-GGA-2565942); (R-GGA-3371497); (R-GGA-3371511); (R-GGA-3371568); (R-GGA-3371571); (R-GGA-380259); (R-GGA-380270); (R-GGA-380284); (R-GGA-380320); (R-GGA-399954); (R-GGA-4420097); (R-GGA-5620912); (R-GGA-5675482); (R-GGA-6798695); (R-GGA-8852276); (R-GGA-8854518); (R-GGA-8863795); (R-GGA-8939211); (R-GGA-9013418); (R-GGA-9018519); (R-GGA-9652282)", "pathway_count": 24, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0051219 phosphoprotein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005886 plasma membrane", "go_biological_process": "GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0034605 cellular response to heat;GO:0032880 regulation of protein localization;GO:0050821 protein stabilization;GO:0002230 positive regulation of defense response to virus by host", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PUL6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PUM9-1", "uniprot_id": [ { "id": "A0A1D5PUM9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PUM9", "type": "external" } ], "mass": 129150.0, "length": 1133, "protein_name": "Family with sequence similarity 83 member H", "gene_name": "FAM83H", "organism": "Chicken", "refseq_name": "protein FAM83H", "refseq_ac": [ { "id": "XP_015138735", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015138735", "type": "external" } ], "gene_names_uniprotkb": "FAM83H", "gene_names_refseq": "FAM83H", "protein_names_uniprotkb": "Family with sequence similarity 83 member H", "protein_names_refseq": "protein FAM83H", "tax_id": 9031, "disease": "", "pathway": " (gga:101750205)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XP_015138735.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990254 keratin filament binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045095 keratin filament", "go_biological_process": "GO:0007165 signal transduction;GO:0030335 positive regulation of cell migration;GO:0044380 protein localization to cytoskeleton;GO:0045104 intermediate filament cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PUM9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PUV4-1", "uniprot_id": [ { "id": "A0A1D5PUV4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PUV4", "type": "external" } ], "mass": 66201.0, "length": 579, "protein_name": "NME/NM23 family member 8", "gene_name": "NME8", "organism": "Chicken", "refseq_name": "thioredoxin domain-containing protein 3 isoform X1", "refseq_ac": [ { "id": "XP_426021", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_426021", "type": "external" } ], "gene_names_uniprotkb": "NME8", "gene_names_refseq": "NME8", "protein_names_uniprotkb": "NME/NM23 family member 8", "protein_names_refseq": "thioredoxin domain-containing protein 3 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:428461)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_426021.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0008017 microtubule binding;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0097598 sperm cytoplasmic droplet;GO:0005634 nucleus;GO:0005829 cytosol;GO:0097228 sperm principal piece;GO:0097225 sperm midpiece", "go_biological_process": "GO:0006308 DNA catabolic process;GO:0006183 GTP biosynthetic process;GO:0006228 UTP biosynthetic process;GO:0006241 CTP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PUV4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PUY2-1", "uniprot_id": [ { "id": "A0A1D5PUY2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PUY2", "type": "external" } ], "mass": 47625.0, "length": 412, "protein_name": "inositol-polyphosphate 5-phosphatase", "gene_name": "INPP5A", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "INPP5A", "gene_names_refseq": "", "protein_names_uniprotkb": "inositol-polyphosphate 5-phosphatase; 3.1.3.56", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:423973); (R-GGA-1855183)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56", "type": "external" } ], "go_molecular_function": "GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0042731 PH domain binding;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite", "go_biological_process": "GO:0046856 phosphatidylinositol dephosphorylation;GO:0050849 negative regulation of calcium-mediated signaling;GO:1900737 negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0043647 inositol phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PUY2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PV61-1", "uniprot_id": [ { "id": "A0A1D5PV61_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PV61", "type": "external" } ], "mass": 88152.0, "length": 786, "protein_name": "DNA-binding protein SATB", "gene_name": "SATB1", "organism": "Chicken", "refseq_name": "DNA-binding protein SATB1 isoform X1", "refseq_ac": [ { "id": "XP_015136971", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015136971", "type": "external" } ], "gene_names_uniprotkb": "SATB1", "gene_names_refseq": "SATB1", "protein_names_uniprotkb": "DNA-binding protein SATB; Special AT-rich sequence-binding protein", "protein_names_refseq": "DNA-binding protein SATB1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:420647); (R-GGA-111465); (R-GGA-4551638)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity", "go_cellular_component": "GO:0016605 PML body;GO:0031981 nuclear lumen", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PV61-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PV76-1", "uniprot_id": [ { "id": "A0A1D5PV76_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PV76", "type": "external" } ], "mass": 46225.0, "length": 406, "protein_name": "Serine/threonine-protein kinase 17A", "gene_name": "STK17A", "organism": "Chicken", "refseq_name": "serine/threonine-protein kinase 17A", "refseq_ac": [ { "id": "NP_001026166", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026166", "type": "external" } ], "gene_names_uniprotkb": "STK17A", "gene_names_refseq": "STK17A", "protein_names_uniprotkb": "Serine/threonine-protein kinase 17A; 2.7.11.1; DAP kinase-related apoptosis-inducing protein kinase 1", "protein_names_refseq": "serine/threonine kinase 17a (apoptosis-inducing); serine/threonine-protein kinase 17A", "tax_id": 9031, "disease": "", "pathway": " (gga:420775)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ719290.1, HAEK01032828.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000037.1. On Sep 23, 2021 this sequence version replaced NP_001026166.1. Sequence Note: This sequence has been modified as follows: removed 29 bp suspected to be vector contamination from the 5' end., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:2000377 regulation of reactive oxygen species metabolic process;GO:2000271 positive regulation of fibroblast apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PV76-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PVA3-1", "uniprot_id": [ { "id": "A0A1D5PVA3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PVA3", "type": "external" } ], "mass": 35077.0, "length": 306, "protein_name": "Ribosome production factor 2 homolog", "gene_name": "RPF2", "organism": "Chicken", "refseq_name": "ribosome production factor 2 homolog isoform X1", "refseq_ac": [ { "id": "XP_426181", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_426181", "type": "external" } ], "gene_names_uniprotkb": "RPF2", "gene_names_refseq": "RPF2", "protein_names_uniprotkb": "Ribosome production factor 2 homolog; Ribosome biogenesis protein RPF2 homolog", "protein_names_refseq": "ribosome production factor 2 homolog isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:428624)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_426181.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0008097 5S rRNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:1902570 protein localization to nucleolus;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0000027 ribosomal large subunit assembly;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000470 maturation of LSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PVA3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PVB6-1", "uniprot_id": [ { "id": "A0A1D5PVB6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PVB6", "type": "external" } ], "mass": 70589.0, "length": 652, "protein_name": "Phosphate transporter", "gene_name": "SLC20A2", "organism": "Chicken", "refseq_name": "sodium-dependent phosphate transporter 2", "refseq_ac": [ { "id": "NP_001292327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292327", "type": "external" } ], "gene_names_uniprotkb": "SLC20A2", "gene_names_refseq": "PiT-2; SLC20A2", "protein_names_uniprotkb": "Phosphate transporter", "protein_names_refseq": "sodium-dependent phosphate transporter 2; solute carrier family 20 (phosphate transporter), member 2", "tax_id": 9031, "disease": "", "pathway": " (gga:422493); (R-GGA-427652)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267656.3089.1, SRR13267654.85339.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000073.1. On Sep 23, 2021 this sequence version replaced NP_001292327.1., [RefSeq]; Sodium-phosphate symporter., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001618 virus receptor activity;GO:0005315 phosphate transmembrane transporter activity;GO:0005436 sodium:phosphate symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane", "go_biological_process": "GO:0035435 phosphate ion transmembrane transport;GO:0006814 sodium ion transport;GO:0006817 phosphate ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PVB6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PVG8-1", "uniprot_id": [ { "id": "A0A1D5PVG8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PVG8", "type": "external" } ], "mass": 54687.0, "length": 483, "protein_name": "Lysosomal Pro-X carboxypeptidase", "gene_name": "PRCP", "organism": "Chicken", "refseq_name": "lysosomal Pro-X carboxypeptidase isoform X1", "refseq_ac": [ { "id": "XP_425654", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_425654", "type": "external" } ], "gene_names_uniprotkb": "PRCP", "gene_names_refseq": "PRCP", "protein_names_uniprotkb": "Lysosomal Pro-X carboxypeptidase; 3.4.16.2; Proline carboxypeptidase; Prolylcarboxypeptidase", "protein_names_refseq": "lysosomal Pro-X carboxypeptidase isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:428096); (R-GGA-6798695); (R-GGA-9970672)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_425654.3. COMPLETENESS: full length., [RefSeq]; Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.4.23.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "3.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" } ], "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0005506 iron ion binding;GO:0004185 serine-type carboxypeptidase activity;GO:0004181 metallocarboxypeptidase activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0045178 basal part of cell;GO:0005764 lysosome", "go_biological_process": "GO:0043535 regulation of blood vessel endothelial cell migration;GO:0002003 angiotensin maturation;GO:0003085 negative regulation of systemic arterial blood pressure;GO:0060055 angiogenesis involved in wound healing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PVG8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PVN2-1", "uniprot_id": [ { "id": "A0A1D5PVN2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PVN2", "type": "external" } ], "mass": 86171.0, "length": 769, "protein_name": "Autophagy-related protein 9", "gene_name": "LOC107055991", "organism": "Chicken", "refseq_name": "autophagy-related protein 9B", "refseq_ac": [ { "id": "XP_025003151", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_025003151", "type": "external" } ], "gene_names_uniprotkb": "LOC107055991", "gene_names_refseq": "LOC107055991", "protein_names_uniprotkb": "Autophagy-related protein 9", "protein_names_refseq": "autophagy-related protein 9B", "tax_id": 9031, "disease": "", "pathway": " (gga:107055991); (R-GGA-1632852)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0005776 autophagosome;GO:0034045 phagophore assembly site membrane;GO:0000407 phagophore assembly site", "go_biological_process": "GO:0034497 protein localization to phagophore assembly site;GO:0000423 mitophagy;GO:0034727 piecemeal microautophagy of the nucleus;GO:0061709 reticulophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PVN2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PVP9-1", "uniprot_id": [ { "id": "A0A1D5PVP9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PVP9", "type": "external" } ], "mass": 130529.0, "length": 1187, "protein_name": "Protogenin", "gene_name": "PRTG", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PRTG", "gene_names_refseq": "", "protein_names_uniprotkb": "Protogenin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:415407)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in anteroposterior axis elongation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0098632 cell-cell adhesion mediator activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0016020 membrane", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411 axon guidance;GO:0050768 negative regulation of neurogenesis;GO:0070593 dendrite self-avoidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PVP9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PVV6-1", "uniprot_id": [ { "id": "A0A1D5PVV6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PVV6", "type": "external" } ], "mass": 34165.0, "length": 299, "protein_name": "Palmitoyltransferase", "gene_name": "ZDHHC3", "organism": "Chicken", "refseq_name": "palmitoyltransferase ZDHHC3 isoform X2", "refseq_ac": [ { "id": "XP_015137227", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015137227", "type": "external" } ], "gene_names_uniprotkb": "ZDHHC3", "gene_names_refseq": "ZDHHC3", "protein_names_uniprotkb": "Palmitoyltransferase; 2.3.1.225", "protein_names_refseq": "palmitoyltransferase ZDHHC3 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:420705)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 2% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" } ], "go_molecular_function": "GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0016020 membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0006612 protein targeting to membrane;GO:0032230 positive regulation of synaptic transmission, GABAergic;GO:0036462 TRAIL-activated apoptotic signaling pathway;GO:0034165 positive regulation of toll-like receptor 9 signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PVV6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PW12-1", "uniprot_id": [ { "id": "A0A1D5PW12_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PW12", "type": "external" } ], "mass": 35438.0, "length": 335, "protein_name": "Hes related family bHLH transcription factor with YRPW motif 2", "gene_name": "HEY2", "organism": "Chicken", "refseq_name": "hairy/enhancer-of-split related with YRPW motif protein 2", "refseq_ac": [ { "id": "XP_015139928", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015139928", "type": "external" } ], "gene_names_uniprotkb": "HEY2", "gene_names_refseq": "HEY2", "protein_names_uniprotkb": "Hes related family bHLH transcription factor with YRPW motif 2", "protein_names_refseq": "hairy/enhancer-of-split related with YRPW motif protein 2", "tax_id": 9031, "disease": "", "pathway": " (gga:421718)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046983 protein dimerization activity;GO:0042802 identical protein binding;GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0017053 transcription repressor complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0006355 regulation of DNA-templated transcription;GO:0032502 developmental process;GO:0072359 circulatory system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PW12-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PW37-1", "uniprot_id": [ { "id": "A0A1D5PW37_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PW37", "type": "external" } ], "mass": 80288.0, "length": 705, "protein_name": "Synaptic vesicle glycoprotein 2B", "gene_name": "SV2B", "organism": "Chicken", "refseq_name": "synaptic vesicle glycoprotein 2B", "refseq_ac": [ { "id": "XP_004943918", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004943918", "type": "external" } ], "gene_names_uniprotkb": "SV2B", "gene_names_refseq": "SV2B", "protein_names_uniprotkb": "Synaptic vesicle glycoprotein 2B", "protein_names_refseq": "synaptic vesicle glycoprotein 2B", "tax_id": 9031, "disease": "", "pathway": " (gga:427508)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052541.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0099509 regulation of presynaptic cytosolic calcium ion concentration;GO:0006836 neurotransmitter transport;GO:2000300 regulation of synaptic vesicle exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PW37-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PW44-1", "uniprot_id": [ { "id": "A0A1D5PW44_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PW44", "type": "external" } ], "mass": 18096.0, "length": 166, "protein_name": "Peptidyl-prolyl cis-trans isomerase", "gene_name": "PPIL1", "organism": "Chicken", "refseq_name": "peptidyl-prolyl cis-trans isomerase-like 1 isoform X1", "refseq_ac": [ { "id": "XP_004951036", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004951036", "type": "external" } ], "gene_names_uniprotkb": "PPIL1", "gene_names_refseq": "PPIL1", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase; 5.2.1.8; PPIase", "protein_names_refseq": "peptidyl-prolyl cis-trans isomerase-like 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-72163)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052557.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" } ], "go_molecular_function": "GO:0097718 disordered domain specific binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0071013 catalytic step 2 spliceosome;GO:0071007 U2-type catalytic step 2 spliceosome", "go_biological_process": "GO:0006457 protein folding;GO:0000398 mRNA splicing, via spliceosome;GO:1990403 embryonic brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PW44-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PW62-1", "uniprot_id": [ { "id": "A0A1D5PW62_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PW62", "type": "external" } ], "mass": 39463.0, "length": 351, "protein_name": "Tropomodulin 2", "gene_name": "TMOD2", "organism": "Chicken", "refseq_name": "tropomodulin-2", "refseq_ac": [ { "id": "XP_015147449", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015147449", "type": "external" } ], "gene_names_uniprotkb": "TMOD2", "gene_names_refseq": "TMOD2", "protein_names_uniprotkb": "Tropomodulin 2", "protein_names_refseq": "tropomodulin-2", "tax_id": 9031, "disease": "", "pathway": " (gga:415422); (R-GGA-390522)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052541.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005865 striated muscle thin filament;GO:0030016 myofibril;GO:0005737 cytoplasm", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0051694 pointed-end actin filament capping;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PW62-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PW90-1", "uniprot_id": [ { "id": "A0A1D5PW90_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PW90", "type": "external" } ], "mass": 24585.0, "length": 211, "protein_name": "Protein N-terminal glutamine amidohydrolase", "gene_name": "WDYHV1", "organism": "Chicken", "refseq_name": "protein N-terminal glutamine amidohydrolase isoform X2", "refseq_ac": [ { "id": "XP_418452", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_418452", "type": "external" } ], "gene_names_uniprotkb": "WDYHV1", "gene_names_refseq": "WDYHV1", "protein_names_uniprotkb": "Protein N-terminal glutamine amidohydrolase; 3.5.1.122; Protein NH2-terminal glutamine deamidase", "protein_names_refseq": "protein N-terminal glutamine amidohydrolase isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:420345)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.122", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.122", "type": "external" } ], "go_molecular_function": "GO:0008418 protein-N-terminal asparagine amidohydrolase activity;GO:0070773 protein-N-terminal glutamine amidohydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PW90-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PWG0-1", "uniprot_id": [ { "id": "A0A1D5PWG0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PWG0", "type": "external" } ], "mass": 303105.0, "length": 2713, "protein_name": "Teneurin-1", "gene_name": "TENM1", "organism": "Chicken", "refseq_name": "teneurin-1 isoform X1", "refseq_ac": [ { "id": "XP_015133675", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015133675", "type": "external" } ], "gene_names_uniprotkb": "TENM1", "gene_names_refseq": "ODZ1; TEN-1; TENM1; ten-m1", "protein_names_uniprotkb": "Teneurin-1; Protein Odd Oz/ten-m homolog 1; Tenascin-M1; Teneurin transmembrane protein 1", "protein_names_refseq": "teneurin-1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:395668)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Induces gene transcription activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007218 neuropeptide signaling pathway;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PWG0-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PWI7-1", "uniprot_id": [ { "id": "A0A1D5PWI7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PWI7", "type": "external" } ], "mass": 23863.0, "length": 214, "protein_name": "DNA replication complex GINS protein PSF3", "gene_name": "GINS3", "organism": "Chicken", "refseq_name": "DNA replication complex GINS protein PSF3 isoform X1", "refseq_ac": [ { "id": "XP_413991", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_413991", "type": "external" } ], "gene_names_uniprotkb": "GINS3", "gene_names_refseq": "GINS3", "protein_names_uniprotkb": "DNA replication complex GINS protein PSF3", "protein_names_refseq": "DNA replication complex GINS protein PSF3 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_413991.1. COMPLETENESS: full length., [RefSeq]; Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built., [UniProtKB, UniProtKB, UniProtKB]; The GINS complex plays an essential role in the initiation of DNA replication., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000811 GINS complex", "go_biological_process": "GO:0006270 DNA replication initiation;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PWI7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PWN4-1", "uniprot_id": [ { "id": "A0A1D5PWN4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PWN4", "type": "external" } ], "mass": 55230.0, "length": 484, "protein_name": "Cysteine protease", "gene_name": "ATG4C", "organism": "Chicken", "refseq_name": "cysteine protease ATG4C isoform X1", "refseq_ac": [ { "id": "XP_040534545", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040534545", "type": "external" } ], "gene_names_uniprotkb": "ATG4C", "gene_names_refseq": "ATG4C", "protein_names_uniprotkb": "Cysteine protease; 3.4.22.-", "protein_names_refseq": "cysteine protease ATG4C isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1632852)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052580.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0019786 protein-phosphatidylethanolamide deconjugating activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0015031 protein transport;GO:0016485 protein processing;GO:0000423 mitophagy;GO:0034727 piecemeal microautophagy of the nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PWN4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PX54-1", "uniprot_id": [ { "id": "A0A1D5PX54_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PX54", "type": "external" } ], "mass": 100054.0, "length": 877, "protein_name": "Interleukin-6 receptor subunit beta", "gene_name": "IL31RA", "organism": "Chicken", "refseq_name": "interleukin-31 receptor subunit alpha isoform X2", "refseq_ac": [ { "id": "XP_004937303", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004937303", "type": "external" } ], "gene_names_uniprotkb": "IL31RA", "gene_names_refseq": "IL31RA", "protein_names_uniprotkb": "Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; Oncostatin-M receptor subunit alpha", "protein_names_refseq": "interleukin-31 receptor subunit alpha isoform X2", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0019221 cytokine-mediated signaling pathway;GO:0030224 monocyte differentiation;GO:0007259 cell surface receptor signaling pathway via JAK-STAT;GO:0070102 interleukin-6-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PX54-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PX74-1", "uniprot_id": [ { "id": "A0A1D5PX74_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PX74", "type": "external" } ], "mass": 68922.0, "length": 601, "protein_name": "Kelch repeat and BTB domain-containing protein 8", "gene_name": "KBTBD8", "organism": "Chicken", "refseq_name": "kelch repeat and BTB domain-containing protein 8 isoform X3", "refseq_ac": [ { "id": "XP_004944729", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004944729", "type": "external" } ], "gene_names_uniprotkb": "KBTBD8", "gene_names_refseq": "KBTBD8", "protein_names_uniprotkb": "Kelch repeat and BTB domain-containing protein 8", "protein_names_refseq": "kelch repeat and BTB domain-containing protein 8 isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:416085); (R-GGA-8951664); (R-GGA-983168)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052543.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005819 spindle;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0014029 neural crest formation;GO:0006417 regulation of translation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0014032 neural crest cell development;GO:0006513 protein monoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PX74-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PX90-1", "uniprot_id": [ { "id": "A0A1D5PX90_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PX90", "type": "external" } ], "mass": 109796.0, "length": 970, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "KSR2", "organism": "Chicken", "refseq_name": "kinase suppressor of Ras 2 isoform X1", "refseq_ac": [ { "id": "XP_015150368", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015150368", "type": "external" } ], "gene_names_uniprotkb": "KSR2", "gene_names_refseq": "KSR2", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "kinase suppressor of Ras 2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:100858301); (R-GGA-5674135)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052546.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XP_015150368.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0031434 mitogen-activated protein kinase kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0007265 Ras protein signal transduction;GO:0120162 positive regulation of cold-induced thermogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PX90-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PXC4-1", "uniprot_id": [ { "id": "A0A1D5PXC4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PXC4", "type": "external" } ], "mass": 16474.0, "length": 151, "protein_name": "Gastrin-releasing peptide", "gene_name": "GRP", "organism": "Chicken", "refseq_name": "gastrin-releasing peptide precursor", "refseq_ac": [ { "id": "NP_001264829", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264829", "type": "external" } ], "gene_names_uniprotkb": "GRP", "gene_names_refseq": "GRP", "protein_names_uniprotkb": "Gastrin-releasing peptide", "protein_names_refseq": "gastrin-releasing peptide precursor; proventricular peptide", "tax_id": 9031, "disease": "", "pathway": " (gga:425213); (R-GGA-375276); (R-GGA-381771); (R-GGA-416476)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "28500250;31585210", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU296686.1, BU234958.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000086.1. On or before Apr 27, 2013 this sequence version replaced XP_001231692.1, XP_422996.3. Sequence Note: This RefSeq record was created from transcript data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Gastrin releasing peptide-induced satiety is associated with hypothalamic and brainstem changes in chicks., [RefSeq, PubMed]; Structural and functional characterization of GRP, neuromedulin B, NMBR, and BRS3 in chickens has been reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:2000987 positive regulation of behavioral fear response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A0A1D5PXC4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PXC7-1", "uniprot_id": [ { "id": "A0A1D5PXC7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PXC7", "type": "external" } ], "mass": 40122.0, "length": 354, "protein_name": "C-X3-C motif chemokine receptor 1", "gene_name": "CX3CR1", "organism": "Chicken", "refseq_name": "CX3C chemokine receptor 1", "refseq_ac": [ { "id": "XP_418820", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_418820", "type": "external" } ], "gene_names_uniprotkb": "CX3CR1", "gene_names_refseq": "CX3CR1", "protein_names_uniprotkb": "C-X3-C motif chemokine receptor 1", "protein_names_refseq": "CX3C chemokine receptor 1", "tax_id": 9031, "disease": "", "pathway": " (gga:420719); (R-GGA-380108); (R-GGA-418594)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004950 chemokine receptor activity;GO:0031737 CX3C chemokine receptor binding;GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0016495 C-X3-C chemokine receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007155 cell adhesion;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PXC7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PXI1-1", "uniprot_id": [ { "id": "A0A1D5PXI1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PXI1", "type": "external" } ], "mass": 60627.0, "length": 551, "protein_name": "Multifunctional fusion protein", "gene_name": "ALDH4A1", "organism": "Chicken", "refseq_name": "delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_001239033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239033", "type": "external" } ], "gene_names_uniprotkb": "ALDH4A1", "gene_names_refseq": "ALDH4A1", "protein_names_uniprotkb": "Multifunctional fusion protein; L-glutamate gamma-semialdehyde dehydrogenase", "protein_names_refseq": "delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (gga:419467); (R-GGA-389661); (R-GGA-70688)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CR733233.1, SRR13267657.23593.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992623 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000329.1. On Nov 5, 2011 this sequence version replaced XP_417624.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.88", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.88", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0003842 L-glutamate gamma-semialdehyde dehydrogenase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010133 L-proline catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PXI1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PXM6-1", "uniprot_id": [ { "id": "A0A1D5PXM6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PXM6", "type": "external" } ], "mass": 35243.0, "length": 311, "protein_name": "Taste receptor type 2", "gene_name": "LOC101747503", "organism": "Chicken", "refseq_name": "taste receptor type 2 member 40-like", "refseq_ac": [ { "id": "XP_004938984", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004938984", "type": "external" } ], "gene_names_uniprotkb": "LOC101747503", "gene_names_refseq": "LOC101747503", "protein_names_uniprotkb": "Taste receptor type 2", "protein_names_refseq": "taste receptor type 2 member 40-like", "tax_id": 9031, "disease": "", "pathway": " (gga:101747503); (R-GGA-418594); (R-GGA-420499); (R-GGA-9717207)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On May 17, 2018 this sequence version replaced XP_004938984.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0033038 bitter taste receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PXM6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PXZ4-1", "uniprot_id": [ { "id": "A0A1D5PXZ4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PXZ4", "type": "external" } ], "mass": 162669.0, "length": 1440, "protein_name": "ATPase family AAA domain containing 2B", "gene_name": "ATAD2B", "organism": "Chicken", "refseq_name": "ATPase family AAA domain-containing protein 2B isoform X3", "refseq_ac": [ { "id": "XP_015140532", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015140532", "type": "external" } ], "gene_names_uniprotkb": "ATAD2B", "gene_names_refseq": "ATAD2B", "protein_names_uniprotkb": "ATPase family AAA domain containing 2B", "protein_names_refseq": "ATPase family AAA domain-containing protein 2B isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:421972)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding;GO:0140566 histone reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0006334 nucleosome assembly;GO:0006337 nucleosome disassembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PXZ4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PY21-1", "uniprot_id": [ { "id": "A0A1D5PY21_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PY21", "type": "external" } ], "mass": 19940.0, "length": 183, "protein_name": "FUN14 domain-containing protein 2", "gene_name": "FUNDC2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FUNDC2", "gene_names_refseq": "", "protein_names_uniprotkb": "FUN14 domain-containing protein 2; Hepatitis C virus core-binding protein 6", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds directly and specifically 1,2-Diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4',5'-bisphosphate) (PIP3) leading to the recruitment of PIP3 to mitochondria and may play a role in the regulation of the platelet activation via AKT/GSK3B/cGMP signaling pathways. May act as transcription factor that regulates SREBP1 (isoform SREBP-1C) expression in order to modulate triglyceride (TG) homeostasis in hepatocytes., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0000422 autophagy of mitochondrion;GO:0035356 intracellular triglyceride homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PY21-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PY49-1", "uniprot_id": [ { "id": "A0A1D5PY49_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PY49", "type": "external" } ], "mass": 13159.0, "length": 118, "protein_name": "Histone H2B", "gene_name": "H2BK1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "H2BK1", "gene_names_refseq": "", "protein_names_uniprotkb": "Histone H2B", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-212300); (R-GGA-2299718); (R-GGA-2559580); (R-GGA-3214847); (R-GGA-427413); (R-GGA-5250924); (R-GGA-5689880); (R-GGA-5693565); (R-GGA-5693571); (R-GGA-5693607); (R-GGA-606279); (R-GGA-68616); (R-GGA-69473); (R-GGA-73728); (R-GGA-73772); (R-GGA-8936459); (R-GGA-9018519); (R-GGA-9764725); (R-GGA-9841922); (R-GGA-9843940); (R-GGA-9843970); (R-GGA-9909649); (R-GGA-9940951); (R-GGA-9943411); (R-GGA-9943962); (R-GGA-9970672)", "pathway_count": 26, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PY49-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PYC2-1", "uniprot_id": [ { "id": "A0A1D5PYC2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PYC2", "type": "external" } ], "mass": 109807.0, "length": 972, "protein_name": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase", "gene_name": "INPP4B", "organism": "Chicken", "refseq_name": "inositol polyphosphate 4-phosphatase type II isoform X1", "refseq_ac": [ { "id": "XP_015132171", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015132171", "type": "external" } ], "gene_names_uniprotkb": "INPP4B", "gene_names_refseq": "INPP4B", "protein_names_uniprotkb": "phosphatidylinositol-3,4-bisphosphate 4-phosphatase; 3.1.3.66", "protein_names_refseq": "inositol polyphosphate 4-phosphatase type II isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1660499); (R-GGA-1660516); (R-GGA-1855183)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.66", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.66", "type": "external" } ], "go_molecular_function": "GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PYC2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PYQ3-1", "uniprot_id": [ { "id": "A0A1D5PYQ3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PYQ3", "type": "external" } ], "mass": 67659.0, "length": 618, "protein_name": "G1 to S phase transition 2", "gene_name": "GSPT2", "organism": "Chicken", "refseq_name": "eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "refseq_ac": [ { "id": "NP_001129149", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129149", "type": "external" } ], "gene_names_uniprotkb": "GSPT2", "gene_names_refseq": "GSPT1; GSPT2", "protein_names_uniprotkb": "G1 to S phase transition 2", "protein_names_refseq": "G1 to S phase transition 1; eukaryotic peptide chain release factor GTP-binding subunit ERF3A", "tax_id": 9031, "disease": "", "pathway": " (gga:768522); (R-GGA-975956); (R-GGA-975957)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01017990.1, HAEK01017525.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000257.1. On Oct 4, 2008 this sequence version replaced XP_001231467.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003747 translation release factor activity", "go_cellular_component": "GO:0018444 translation release factor complex;GO:0022626 cytosolic ribosome;GO:0005829 cytosol", "go_biological_process": "GO:0006449 regulation of translational termination;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PYQ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PZ39-1", "uniprot_id": [ { "id": "A0A1D5PZ39_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PZ39", "type": "external" } ], "mass": 62556.0, "length": 570, "protein_name": "Docking protein 1", "gene_name": "DOK1", "organism": "Chicken", "refseq_name": "docking protein 1", "refseq_ac": [ { "id": "XP_015156788", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015156788", "type": "external" } ], "gene_names_uniprotkb": "DOK1", "gene_names_refseq": "DOK1", "protein_names_uniprotkb": "Docking protein 1", "protein_names_refseq": "docking protein 1", "tax_id": 9031, "disease": "", "pathway": " (gga:430423); (R-GGA-8853659)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "", "go_biological_process": "GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PZ39-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PZ51-1", "uniprot_id": [ { "id": "A0A1D5PZ51_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PZ51", "type": "external" } ], "mass": 70714.0, "length": 654, "protein_name": "Dihydropyrimidinase like 3", "gene_name": "DPYSL3", "organism": "Chicken", "refseq_name": "dihydropyrimidinase-related protein 3 isoform X1", "refseq_ac": [ { "id": "XP_015149473", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015149473", "type": "external" } ], "gene_names_uniprotkb": "DPYSL3", "gene_names_refseq": "CRMP4A; CRMP4B; DPYSL3", "protein_names_uniprotkb": "Dihydropyrimidinase like 3", "protein_names_refseq": "dihydropyrimidinase-related protein 3 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-399956)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051219 phosphoprotein binding;GO:0031005 filamin binding;GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides;GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds", "go_cellular_component": "GO:0005829 cytosol;GO:0030426 growth cone;GO:0005737 cytoplasm", "go_biological_process": "GO:0051764 actin crosslink formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PZ51-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PZA4-1", "uniprot_id": [ { "id": "A0A1D5PZA4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PZA4", "type": "external" } ], "mass": 55329.0, "length": 493, "protein_name": "Angiopoietin 4", "gene_name": "ANGPT4", "organism": "Chicken", "refseq_name": "angiopoietin-4", "refseq_ac": [ { "id": "XP_001235003", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001235003", "type": "external" } ], "gene_names_uniprotkb": "ANGPT4", "gene_names_refseq": "ANGPT4", "protein_names_uniprotkb": "Angiopoietin 4", "protein_names_refseq": "angiopoietin-4", "tax_id": 9031, "disease": "", "pathway": " (gga:771763); (R-GGA-210993)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052551.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_001235003.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0001525 angiogenesis;GO:0007165 signal transduction;GO:0043066 negative regulation of apoptotic process;GO:0007596 blood coagulation;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PZA4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PZE5-1", "uniprot_id": [ { "id": "A0A1D5PZE5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PZE5", "type": "external" } ], "mass": 31733.0, "length": 302, "protein_name": "CCAAT enhancer binding protein delta", "gene_name": "CEBPD", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CEBPD", "gene_names_refseq": "", "protein_names_uniprotkb": "CCAAT enhancer binding protein delta", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045595 regulation of cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PZE5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PZI6-1", "uniprot_id": [ { "id": "A0A1D5PZI6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PZI6", "type": "external" } ], "mass": 32678.0, "length": 281, "protein_name": "Inhibitor of growth protein", "gene_name": "ING1", "organism": "Chicken", "refseq_name": "inhibitor of growth protein 1 isoform X1", "refseq_ac": [ { "id": "XP_015133367", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015133367", "type": "external" } ], "gene_names_uniprotkb": "ING1", "gene_names_refseq": "ING1", "protein_names_uniprotkb": "Inhibitor of growth protein", "protein_names_refseq": "inhibitor of growth protein 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:418759)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Component of an histone acetyltransferase complex., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140002 histone H3K4me3 reader activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PZI6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PZQ6-1", "uniprot_id": [ { "id": "A0A1D5PZQ6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PZQ6", "type": "external" } ], "mass": 25387.0, "length": 222, "protein_name": "Homeobox B6", "gene_name": "HOXB6", "organism": "Chicken", "refseq_name": "homeobox protein Hox-B6", "refseq_ac": [ { "id": "NP_001383565", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383565", "type": "external" } ], "gene_names_uniprotkb": "HOXB6", "gene_names_refseq": "GHOX-2.2; HOXB6", "protein_names_uniprotkb": "Homeobox B6", "protein_names_refseq": "Homeobox protein Hox-2.2; homeobox protein Hox-B6-like; homeobox protein Hox-B6", "tax_id": 9031, "disease": "", "pathway": " (gga:777548)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX931212.2, BX271059.4 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX931212.2, BU270850.1 and JAENSK010000364.1. On or before Oct 25, 2021 this sequence version replaced XP_015154927.1, XP_040547909.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PZQ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PZT4-1", "uniprot_id": [ { "id": "A0A1D5PZT4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PZT4", "type": "external" } ], "mass": 9632.0, "length": 84, "protein_name": "GTP cyclohydrolase 1 feedback regulatory protein", "gene_name": "GCHFR", "organism": "Chicken", "refseq_name": "GTP cyclohydrolase 1 feedback regulatory protein", "refseq_ac": [ { "id": "NP_001186451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186451", "type": "external" } ], "gene_names_uniprotkb": "GCHFR", "gene_names_refseq": "GCHFR", "protein_names_uniprotkb": "GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulatory protein", "protein_names_refseq": "GTP cyclohydrolase 1 feedback regulatory protein; GTP cyclohydrolase I feedback regulatory protein", "tax_id": 9031, "disease": "", "pathway": " (gga:423003); (R-GGA-1474151)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CV859541.1, BX933750.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000212.1. On Dec 9, 2010 this sequence version replaced XP_420935.2., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004857 enzyme inhibitor activity;GO:0044549 GTP cyclohydrolase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030425 dendrite", "go_biological_process": "GO:0009890 negative regulation of biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PZT4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PZX4-1", "uniprot_id": [ { "id": "A0A1D5PZX4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PZX4", "type": "external" } ], "mass": 35653.0, "length": 322, "protein_name": "Solute carrier family 25 member 32", "gene_name": "SLC25A32", "organism": "Chicken", "refseq_name": "solute carrier family 25 member 32", "refseq_ac": [ { "id": "NP_001026677", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026677", "type": "external" } ], "gene_names_uniprotkb": "SLC25A32", "gene_names_refseq": "SLC25A32", "protein_names_uniprotkb": "Solute carrier family 25 member 32; Mitochondrial FAD transporter", "protein_names_refseq": "mitochondrial folate transporter/carrier; solute carrier family 25 (mitochondrial folate carrier), member 32; solute carrier family 25 member 32", "tax_id": 9031, "disease": "", "pathway": " (gga:428377); (R-GGA-196757)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720399.1, SRR13267659.126462.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000044.1. On Sep 23, 2021 this sequence version replaced NP_001026677.1., [RefSeq]; Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015230 FAD transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:1990548 mitochondrial FAD transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PZX4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5Q032-1", "uniprot_id": [ { "id": "A0A1D5Q032_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5Q032", "type": "external" } ], "mass": 51079.0, "length": 469, "protein_name": "Adenylyl cyclase-associated protein", "gene_name": "CAP1", "organism": "Chicken", "refseq_name": "adenylyl cyclase-associated protein 1 isoform X3", "refseq_ac": [ { "id": "XP_040507775", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040507775", "type": "external" } ], "gene_names_uniprotkb": "CAP1", "gene_names_refseq": "CAP1", "protein_names_uniprotkb": "Adenylyl cyclase-associated protein", "protein_names_refseq": "adenylyl cyclase-associated protein 1 isoform X3", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-6798695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052554.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0008179 adenylate cyclase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0030864 cortical actin cytoskeleton", "go_biological_process": "GO:0098885 modification of postsynaptic actin cytoskeleton;GO:0007015 actin filament organization;GO:0000902 cell morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5Q032-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D6UPS9-1", "uniprot_id": [ { "id": "A0A1D6UPS9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D6UPS9", "type": "external" } ], "mass": 135490.0, "length": 1217, "protein_name": "Splicing factor 3B subunit 3", "gene_name": "SF3B3", "organism": "Chicken", "refseq_name": "splicing factor 3B subunit 3", "refseq_ac": [ { "id": "XP_001232348", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001232348", "type": "external" } ], "gene_names_uniprotkb": "SF3B3", "gene_names_refseq": "SF3B3", "protein_names_uniprotkb": "Splicing factor 3B subunit 3", "protein_names_refseq": "splicing factor 3B subunit 3", "tax_id": 9031, "disease": "", "pathway": " (gga:415680); (R-GGA-72165); (R-GGA-9770562)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052542.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_001232348.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030620 U2 snRNA binding;GO:0044877 protein-containing complex binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP", "go_biological_process": "GO:0042177 negative regulation of protein catabolic process;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D6UPS9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D6UPU4-1", "uniprot_id": [ { "id": "A0A1D6UPU4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D6UPU4", "type": "external" } ], "mass": 39147.0, "length": 350, "protein_name": "Patatin like phospholipase domain containing 4", "gene_name": "PNPLA4", "organism": "Chicken", "refseq_name": "patatin-like phospholipase domain-containing protein 4", "refseq_ac": [ { "id": "NP_001124212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124212", "type": "external" } ], "gene_names_uniprotkb": "PNPLA4", "gene_names_refseq": "PNPLA4", "protein_names_uniprotkb": "Patatin like phospholipase domain containing 4", "protein_names_refseq": "patatin-like phospholipase domain-containing protein 4", "tax_id": 9031, "disease": "", "pathway": " (gga:418653); (R-GGA-163560)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: ERR2286007.139094.1, ERR2365565.118149.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000024.1. On or before Dec 6, 2021 this sequence version replaced XP_015129473.2, NP_001124212.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0004806 triacylglycerol lipase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0051264 mono-olein transacylation activity;GO:0051265 diolein transacylation activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0055088 lipid homeostasis;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D6UPU4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1I7Q405-1", "uniprot_id": [ { "id": "A0A1I7Q405_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1I7Q405", "type": "external" } ], "mass": 45421.0, "length": 397, "protein_name": "Cysteine protease", "gene_name": "ATG4A", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ATG4A", "gene_names_refseq": "", "protein_names_uniprotkb": "Cysteine protease; 3.4.22.-", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1632852)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0019786 protein-phosphatidylethanolamide deconjugating activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0006629 lipid metabolic process;GO:0015031 protein transport;GO:0016485 protein processing;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1I7Q405-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RIY4-1", "uniprot_id": [ { "id": "A0A1L1RIY4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RIY4", "type": "external" } ], "mass": 62941.0, "length": 572, "protein_name": "Argininosuccinate lyase", "gene_name": "ASL", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ASL", "gene_names_refseq": "", "protein_names_uniprotkb": "Argininosuccinate lyase", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-70635)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004056 argininosuccinate lyase activity;GO:0005212 structural constituent of eye lens", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0045429 positive regulation of nitric oxide biosynthetic process;GO:0042450 L-arginine biosynthetic process via ornithine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RIY4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RIZ5-1", "uniprot_id": [ { "id": "A0A1L1RIZ5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RIZ5", "type": "external" } ], "mass": 38067.0, "length": 346, "protein_name": "Goosecoid homeobox", "gene_name": "GSC", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GSC", "gene_names_refseq": "", "protein_names_uniprotkb": "Goosecoid homeobox", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0042474 middle ear morphogenesis;GO:0014036 neural crest cell fate specification;GO:0009888 tissue development;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RIZ5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RJ90-1", "uniprot_id": [ { "id": "A0A1L1RJ90_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RJ90", "type": "external" } ], "mass": 33714.0, "length": 319, "protein_name": "Hydroxymethylglutaryl-CoA lyase, mitochondrial", "gene_name": "HMGCL", "organism": "Chicken", "refseq_name": "hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001185643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185643", "type": "external" } ], "gene_names_uniprotkb": "HMGCL", "gene_names_refseq": "HL; HMGCL", "protein_names_uniprotkb": "Hydroxymethylglutaryl-CoA lyase, mitochondrial; 3-hydroxy-3-methylglutarate-CoA lyase; 4.1.3.4", "protein_names_refseq": "3-Hydroxy-3-methylglutaryl coenzyme A lyase; 3-hydroxy-3-methylglutarate-CoA lyase; 3-hydroxy-3-methylglutaryl-CoA lyase; HMG-CoA lyase; hydroxymethylglutaryl-CoA lyase, mitochondrial isoform 2; hydroxymethylglutaryl-CoA lyase, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (gga:396316); (R-GGA-77111); (R-GGA-9033241)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01000219.1, BX931402.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000339.1. On Nov 10, 2010 this sequence version replaced XP_417834.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1.The resulting protein (isoform 2) is the same length but has a distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "4.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.9", "type": "external" }, { "id": "3.6.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.77", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "2.6.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.51", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.124", "type": "external" }, { "id": "5.1.99.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.99.4", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004419 hydroxymethylglutaryl-CoA lyase activity;GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005777 peroxisome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0046951 ketone body biosynthetic process;GO:0006552 L-leucine catabolic process;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RJ90-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RJB3-1", "uniprot_id": [ { "id": "A0A1L1RJB3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RJB3", "type": "external" } ], "mass": 30041.0, "length": 263, "protein_name": "Myozenin 2", "gene_name": "MYOZ2", "organism": "Chicken", "refseq_name": "myozenin-2", "refseq_ac": [ { "id": "NP_001264756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264756", "type": "external" } ], "gene_names_uniprotkb": "MYOZ2", "gene_names_refseq": "MYOZ2", "protein_names_uniprotkb": "Myozenin 2", "protein_names_refseq": "myozenin-2", "tax_id": 9031, "disease": "", "pathway": " (gga:422682)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX935788.2, BU250595.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA3109051 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BX935788.2. On Apr 21, 2013 this sequence version replaced XP_420634.2., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0051373 FATZ binding;GO:0031433 telethonin binding", "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0030018 Z disc", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0043503 skeletal muscle fiber adaptation;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade;GO:0045214 sarcomere organization;GO:0007519 skeletal muscle tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RJB3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RJP8-1", "uniprot_id": [ { "id": "A0A1L1RJP8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RJP8", "type": "external" } ], "mass": 55275.0, "length": 499, "protein_name": "Tubulin alpha chain", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubulin alpha chain", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-114608); (R-GGA-2467813); (R-GGA-2500257); (R-GGA-2565942); (R-GGA-3371497); (R-GGA-380259); (R-GGA-380270); (R-GGA-380284); (R-GGA-380320); (R-GGA-5620912); (R-GGA-5620924); (R-GGA-6807878); (R-GGA-6811434); (R-GGA-6811436); (R-GGA-8854518); (R-GGA-9646399); (R-GGA-9648025); (R-GGA-983189)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RJP8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RK74-1", "uniprot_id": [ { "id": "A0A1L1RK74_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RK74", "type": "external" } ], "mass": 26651.0, "length": 233, "protein_name": "Oligoribonuclease, mitochondrial", "gene_name": "REXO2", "organism": "Chicken", "refseq_name": "oligoribonuclease, mitochondrial", "refseq_ac": [ { "id": "NP_001265049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265049", "type": "external" } ], "gene_names_uniprotkb": "REXO2", "gene_names_refseq": "REXO2; SMFN", "protein_names_uniprotkb": "Oligoribonuclease, mitochondrial; RNA exonuclease 2 homolog; Small fragment nuclease", "protein_names_refseq": "REX2, RNA exonuclease 2 homolog; oligoribonuclease, mitochondrial; small fragment nuclease", "tax_id": 9031, "disease": "", "pathway": " (gga:419761)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01148138.1, HAEL01005291.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000341.1. On May 11, 2013 this sequence version replaced XP_417900.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides. Binds and degrades longer oligonucleotides with a lower affinity. Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing. Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome. Essential for embryonic development., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0000287 magnesium ion binding;GO:0003676 nucleic acid binding;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:2000827 mitochondrial RNA surveillance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RK74-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RKD7-1", "uniprot_id": [ { "id": "A0A1L1RKD7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RKD7", "type": "external" } ], "mass": 10372.0, "length": 99, "protein_name": "N-alpha-acetyltransferase 38, NatC auxiliary subunit", "gene_name": "NAA38", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NAA38; LOC107054771; LOC121106519", "gene_names_refseq": "", "protein_names_uniprotkb": "N-alpha-acetyltransferase 38, NatC auxiliary subunit", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0031417 NatC complex", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RKD7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RKT0-1", "uniprot_id": [ { "id": "A0A1L1RKT0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RKT0", "type": "external" } ], "mass": 56865.0, "length": 495, "protein_name": "Glycylpeptide N-tetradecanoyltransferase", "gene_name": "NMT1", "organism": "Chicken", "refseq_name": "glycylpeptide N-tetradecanoyltransferase 1", "refseq_ac": [ { "id": "XP_418088", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_418088", "type": "external" } ], "gene_names_uniprotkb": "NMT1", "gene_names_refseq": "NMT1", "protein_names_uniprotkb": "Glycylpeptide N-tetradecanoyltransferase; 2.3.1.97", "protein_names_refseq": "glycylpeptide N-tetradecanoyltransferase 1", "tax_id": 9031, "disease": "", "pathway": " (gga:419966); (R-GGA-2514859); (R-GGA-75108)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052558.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.97", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.97", "type": "external" } ], "go_molecular_function": "GO:0004379 glycylpeptide N-tetradecanoyltransferase activity;GO:0018030 peptidyl-lysine N6-myristoyltransferase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0042180 ketone metabolic process;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RKT0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RKV7-1", "uniprot_id": [ { "id": "A0A1L1RKV7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RKV7", "type": "external" } ], "mass": 11753.0, "length": 114, "protein_name": "Eukaryotic translation initiation factor 4E binding protein 2", "gene_name": "EIF4EBP2", "organism": "Chicken", "refseq_name": "eukaryotic translation initiation factor 4E-binding protein 2", "refseq_ac": [ { "id": "NP_001308563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308563", "type": "external" } ], "gene_names_uniprotkb": "EIF4EBP2", "gene_names_refseq": "EIF4EBP2", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 4E binding protein 2", "protein_names_refseq": "eukaryotic translation initiation factor 4E-binding protein 2", "tax_id": 9031, "disease": "", "pathway": " (gga:769479)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX932433.2, BX935879.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000230.1. On Mar 29, 2016 this sequence version replaced XP_015143729.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008190 eukaryotic initiation factor 4E binding;GO:0030371 translation repressor activity", "go_cellular_component": "GO:0071598 neuronal ribonucleoprotein granule", "go_biological_process": "GO:0007613 memory;GO:0048167 regulation of synaptic plasticity;GO:0035176 social behavior;GO:0045947 negative regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RKV7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RKZ0-1", "uniprot_id": [ { "id": "A0A1L1RKZ0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RKZ0", "type": "external" } ], "mass": 28229.0, "length": 250, "protein_name": "small monomeric GTPase", "gene_name": "RASL11AL", "organism": "Chicken", "refseq_name": "ras-like protein family member 11A-like", "refseq_ac": [ { "id": "XP_420297", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_420297", "type": "external" } ], "gene_names_uniprotkb": "RASL11AL", "gene_names_refseq": "RASL11AL", "protein_names_uniprotkb": "small monomeric GTPase; 3.6.5.2", "protein_names_refseq": "ras-like protein family member 11A-like", "tax_id": 9031, "disease": "", "pathway": " (gga:422321)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RKZ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RLD5-1", "uniprot_id": [ { "id": "A0A1L1RLD5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RLD5", "type": "external" } ], "mass": 33228.0, "length": 298, "protein_name": "Olfactory receptor", "gene_name": "", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RLD5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RLE3-1", "uniprot_id": [ { "id": "A0A1L1RLE3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RLE3", "type": "external" } ], "mass": 37318.0, "length": 324, "protein_name": "RNA ligase 1", "gene_name": "C12orf29", "organism": "Chicken", "refseq_name": "uncharacterized protein C12orf29 homolog isoform X1", "refseq_ac": [ { "id": "XP_025010384", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_025010384", "type": "external" } ], "gene_names_uniprotkb": "C12orf29", "gene_names_refseq": "C12orf29", "protein_names_uniprotkb": "RNA ligase 1; 6.5.1.3; RNA ligase", "protein_names_refseq": "uncharacterized protein C12orf29 homolog isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:417886)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Functions as an RNA ligase, in vitro. The ligation reaction entails three nucleotidyl transfer steps. In the first step, the RNA ligase reacts with ATP in the absence of nucleic acid to form a covalent ligase-AMP intermediate and release pyrophosphate. In step 2, the ligase-AMP binds to the nucleic acid and transfers the adenylate to the 5'-PO4 terminus to form an adenylylated intermediate. In step 3, the RNA ligase directs the attack of the 3'-OH on the 5'-phosphoanhydride linkage, resulting in a repaired 3'-5' phosphodiester and release of AMP. Exhibits selectivity for single-stranded RNA substrates and may not have nick-sealing activity on double-stranded DNA-RNA hybrids. May play a role in maintaining RNA integrity under stress conditions, for example in response to reactive oxygen species (ROS)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0003972 RNA ligase (ATP) activity", "go_cellular_component": "", "go_biological_process": "GO:0000302 response to reactive oxygen species;GO:0042245 RNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RLE3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RLU3-1", "uniprot_id": [ { "id": "A0A1L1RLU3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RLU3", "type": "external" } ], "mass": 18341.0, "length": 165, "protein_name": "Mitochondrial inner membrane protease subunit", "gene_name": "IMMP1L", "organism": "Chicken", "refseq_name": "mitochondrial inner membrane protease subunit 1 isoform X1", "refseq_ac": [ { "id": "XP_040557079", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040557079", "type": "external" } ], "gene_names_uniprotkb": "IMMP1L", "gene_names_refseq": "IMMP1L", "protein_names_uniprotkb": "Mitochondrial inner membrane protease subunit; 3.4.21.-", "protein_names_refseq": "mitochondrial inner membrane protease subunit 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:771365)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0004175 endopeptidase activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0042720 mitochondrial inner membrane peptidase complex", "go_biological_process": "GO:0006465 signal peptide processing;GO:0006627 protein processing involved in protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RLU3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RM96-1", "uniprot_id": [ { "id": "A0A1L1RM96_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RM96", "type": "external" } ], "mass": 57122.0, "length": 516, "protein_name": "Pleiotropic regulator 1", "gene_name": "PLRG1", "organism": "Chicken", "refseq_name": "pleiotropic regulator 1", "refseq_ac": [ { "id": "XP_420368", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_420368", "type": "external" } ], "gene_names_uniprotkb": "PLRG1", "gene_names_refseq": "PLRG1", "protein_names_uniprotkb": "Pleiotropic regulator 1", "protein_names_refseq": "pleiotropic regulator 1", "tax_id": 9031, "disease": "", "pathway": " (gga:422401); (R-GGA-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_420368.1. COMPLETENESS: full length., [RefSeq]; Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0016607 nuclear speck;GO:0031965 nuclear membrane;GO:0001650 fibrillar center;GO:0071013 catalytic step 2 spliceosome;GO:0005662 DNA replication factor A complex", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RM96-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RMQ9-1", "uniprot_id": [ { "id": "A0A1L1RMQ9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RMQ9", "type": "external" } ], "mass": 35049.0, "length": 312, "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "LOC107053361", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC107053361", "gene_names_refseq": "", "protein_names_uniprotkb": "G-protein coupled receptors family 1 profile domain-containing protein", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Odorant receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity;GO:0005549 odorant binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RMQ9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RNI5-1", "uniprot_id": [ { "id": "A0A1L1RNI5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RNI5", "type": "external" } ], "mass": 63453.0, "length": 558, "protein_name": "Atlastin-1", "gene_name": "ATL1", "organism": "Chicken", "refseq_name": "atlastin-1 isoform X1", "refseq_ac": [ { "id": "XP_015132234", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015132234", "type": "external" } ], "gene_names_uniprotkb": "ATL1", "gene_names_refseq": "ATL1", "protein_names_uniprotkb": "Atlastin-1", "protein_names_refseq": "atlastin-1 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Atlastin-1 (ATL1) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect. Two atlastin-1 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle. May also regulate more or less directly Golgi biogenesis. Indirectly regulates axonal development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0140523 GTPase-dependent fusogenic activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030424 axon;GO:0005789 endoplasmic reticulum membrane;GO:0098826 endoplasmic reticulum tubular network membrane", "go_biological_process": "GO:0051260 protein homooligomerization;GO:1990809 endoplasmic reticulum tubular network membrane organization;GO:0007029 endoplasmic reticulum organization;GO:0016320 endoplasmic reticulum membrane fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RNI5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RP76-1", "uniprot_id": [ { "id": "A0A1L1RP76_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RP76", "type": "external" } ], "mass": 69248.0, "length": 644, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "SH3RF2", "organism": "Chicken", "refseq_name": "E3 ubiquitin-protein ligase SH3RF2 isoform X1", "refseq_ac": [ { "id": "XP_004945098", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004945098", "type": "external" } ], "gene_names_uniprotkb": "SH3RF2", "gene_names_refseq": "SH3RF2", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase SH3RF2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:416346)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0008157 protein phosphatase 1 binding", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0031397 negative regulation of protein ubiquitination;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RP76-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RPZ3-1", "uniprot_id": [ { "id": "A0A1L1RPZ3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RPZ3", "type": "external" } ], "mass": 22433.0, "length": 196, "protein_name": "5'-deoxynucleotidase HDDC2", "gene_name": "HDDC2", "organism": "Chicken", "refseq_name": "5'-deoxynucleotidase HDDC2", "refseq_ac": [ { "id": "NP_001264847", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264847", "type": "external" } ], "gene_names_uniprotkb": "HDDC2", "gene_names_refseq": "HDDC2", "protein_names_uniprotkb": "5'-deoxynucleotidase HDDC2; 3.1.3.89; HD domain-containing protein 2", "protein_names_refseq": "5'-deoxynucleotidase HDDC2", "tax_id": 9031, "disease": "", "pathway": " (gga:421719)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BU388637.1, BU348699.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000063.1. On Apr 28, 2013 this sequence version replaced XP_419755.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data from different strains because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0002953 5'-deoxynucleotidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0009159 deoxyribonucleoside monophosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RPZ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PEI6-1", "uniprot_id": [ { "id": "A0A1D5PEI6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PEI6", "type": "external" } ], "mass": 104169.0, "length": 933, "protein_name": "alpha-1,2-Mannosidase", "gene_name": "EDEM3", "organism": "Chicken", "refseq_name": "ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X2", "refseq_ac": [ { "id": "XP_422293", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_422293", "type": "external" } ], "gene_names_uniprotkb": "EDEM3", "gene_names_refseq": "EDEM3", "protein_names_uniprotkb": "alpha-1,2-Mannosidase; 3.2.1.-", "protein_names_refseq": "ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:424450)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052539.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_422293.4. COMPLETENESS: full length., [RefSeq]; Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. May also participate in mannose trimming from all glycoproteins and not just misfolded ones targeted to ERAD. May have alpha 1,2-mannosidase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0016020 membrane;GO:0044322 endoplasmic reticulum quality control compartment;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0036503 ERAD pathway;GO:1904380 endoplasmic reticulum mannose trimming;GO:0006986 response to unfolded protein;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PEI6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1D5PMW7-1", "uniprot_id": [ { "id": "A0A1D5PMW7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1D5PMW7", "type": "external" } ], "mass": 54417.0, "length": 474, "protein_name": "Gamma-aminobutyric acid type A receptor beta2 subunit", "gene_name": "GABRB2", "organism": "Chicken", "refseq_name": "gamma-aminobutyric acid receptor subunit beta-2 isoform X3", "refseq_ac": [ { "id": "XP_046756279", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046756279", "type": "external" } ], "gene_names_uniprotkb": "GABRB2", "gene_names_refseq": "GABARB; GABRB2", "protein_names_uniprotkb": "Gamma-aminobutyric acid type A receptor beta2 subunit", "protein_names_refseq": "gamma-aminobutyric acid receptor subunit beta-2 isoform X3", "tax_id": 9031, "disease": "", "pathway": " (gga:414890); (R-GGA-977443)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity;GO:0022851 GABA-gated chloride ion channel activity;GO:1904315 transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex;GO:0098982 GABA-ergic synapse;GO:0043197 dendritic spine", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0060384 innervation;GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0060119 inner ear receptor cell development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1D5PMW7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2UAL7-1", "uniprot_id": [ { "id": "A0A3Q2UAL7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2UAL7", "type": "external" } ], "mass": 48428.0, "length": 438, "protein_name": "Purine nucleoside phosphorylase LACC1", "gene_name": "LACC1", "organism": "Chicken", "refseq_name": "purine nucleoside phosphorylase LACC1 isoform X4", "refseq_ac": [ { "id": "XP_015132114", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015132114", "type": "external" } ], "gene_names_uniprotkb": "LACC1", "gene_names_refseq": "LACC1", "protein_names_uniprotkb": "Purine nucleoside phosphorylase LACC1; 2.4.2.1; 2.4.2.28; 3.5.4.4; Adenosine deaminase LACC1; Fatty acid metabolism-immunity nexus; Guanosine phosphorylase LACC1; Isocyanic acid synthase; Laccase domain-containing protein 1; S-methyl-5'-thioadenosine phosphorylase LACC1", "protein_names_refseq": "purine nucleoside phosphorylase LACC1 isoform X4", "tax_id": 9031, "disease": "", "pathway": " (gga:418840)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0017061 S-methyl-5-thioadenosine phosphorylase activity;GO:0004000 adenosine deaminase activity;GO:0005507 copper ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0031347 regulation of defense response;GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2UAL7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1S0X5-1", "uniprot_id": [ { "id": "A0A1L1S0X5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1S0X5", "type": "external" } ], "mass": 13306.0, "length": 117, "protein_name": "Large ribosomal subunit protein eL34", "gene_name": "RPL34", "organism": "Chicken", "refseq_name": "large ribosomal subunit protein eL34", "refseq_ac": [ { "id": "NP_001268429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268429", "type": "external" } ], "gene_names_uniprotkb": "RPL34", "gene_names_refseq": "RPL34", "protein_names_uniprotkb": "Large ribosomal subunit protein eL34; 60S ribosomal protein L34", "protein_names_refseq": "large ribosomal subunit protein eL34", "tax_id": 9031, "disease": "", "pathway": " (gga:422526); (R-GGA-1799339); (R-GGA-72706); (R-GGA-975956); (R-GGA-975957); (R-GGA-9954709); (R-GGA-9954714); (R-GGA-9954716)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "38395592", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CF251027.1, DR430813.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992415, SAMEA103992432 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000073.1. On or before Jul 31, 2013 this sequence version replaced XP_003643704.1, XP_004941101.1, XP_420489.3., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1D5NTR6", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0046872 metal ion binding", "go_cellular_component": "GO:0022625 cytosolic large ribosomal subunit;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1L1S0X5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2U9U9-1", "uniprot_id": [ { "id": "A0A3Q2U9U9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2U9U9", "type": "external" } ], "mass": 58116.0, "length": 533, "protein_name": "Serine/threonine-protein kinase OSR1", "gene_name": "OXSR1", "organism": "Chicken", "refseq_name": "serine/threonine-protein kinase OSR1 isoform X1", "refseq_ac": [ { "id": "XP_418527", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_418527", "type": "external" } ], "gene_names_uniprotkb": "OXSR1", "gene_names_refseq": "OXSR1", "protein_names_uniprotkb": "Serine/threonine-protein kinase OSR1; 2.7.11.1; Oxidative stress-responsive 1 protein", "protein_names_refseq": "serine/threonine-protein kinase OSR1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:420421)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0010820 positive regulation of T cell chemotaxis;GO:0035556 intracellular signal transduction;GO:0071474 cellular hyperosmotic response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2U9U9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2UFV6-1", "uniprot_id": [ { "id": "A0A3Q2UFV6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2UFV6", "type": "external" } ], "mass": 83382.0, "length": 761, "protein_name": "Cartilage oligomeric matrix protein", "gene_name": "COMP", "organism": "Chicken", "refseq_name": "cartilage oligomeric matrix protein", "refseq_ac": [ { "id": "XP_418238", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_418238", "type": "external" } ], "gene_names_uniprotkb": "COMP", "gene_names_refseq": "COMP", "protein_names_uniprotkb": "Cartilage oligomeric matrix protein", "protein_names_refseq": "cartilage oligomeric matrix protein", "tax_id": 9031, "disease": "", "pathway": " (gga:420120); (R-GGA-216083)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052559.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_418238.1. COMPLETENESS: full length., [RefSeq]; Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2UFV6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2U9L8-1", "uniprot_id": [ { "id": "A0A3Q2U9L8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2U9L8", "type": "external" } ], "mass": 70361.0, "length": 607, "protein_name": "Protein SCAI", "gene_name": "SCAI", "organism": "Chicken", "refseq_name": "protein SCAI isoform X4", "refseq_ac": [ { "id": "XP_046757797", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046757797", "type": "external" } ], "gene_names_uniprotkb": "SCAI", "gene_names_refseq": "SCAI", "protein_names_uniprotkb": "Protein SCAI", "protein_names_refseq": "protein SCAI isoform X4", "tax_id": 9031, "disease": "", "pathway": " (gga:427751)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052548.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003714 transcription corepressor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0031965 nuclear membrane;GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030336 negative regulation of cell migration;GO:0035024 negative regulation of Rho protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2U9L8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2U1T2-1", "uniprot_id": [ { "id": "A0A3Q2U1T2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2U1T2", "type": "external" } ], "mass": 56531.0, "length": 499, "protein_name": "Tyrosine-protein kinase", "gene_name": "BLK", "organism": "Chicken", "refseq_name": "tyrosine-protein kinase Blk isoform X2", "refseq_ac": [ { "id": "XP_420040", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_420040", "type": "external" } ], "gene_names_uniprotkb": "BLK", "gene_names_refseq": "BLK", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "tyrosine-protein kinase Blk isoform X2", "tax_id": 9031, "disease": "", "pathway": " (gga:422035)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 19, 2013 this sequence version replaced XP_420040.3. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005102 signaling receptor binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0030154 cell differentiation;GO:0032024 positive regulation of insulin secretion;GO:0050853 B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2U1T2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RR91-1", "uniprot_id": [ { "id": "A0A1L1RR91_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RR91", "type": "external" } ], "mass": 40382.0, "length": 358, "protein_name": "DnaJ homolog subfamily B member 11", "gene_name": "DNAJB11", "organism": "Chicken", "refseq_name": "dnaJ homolog subfamily B member 11", "refseq_ac": [ { "id": "XP_422682", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_422682", "type": "external" } ], "gene_names_uniprotkb": "DNAJB11", "gene_names_refseq": "DNAJB11", "protein_names_uniprotkb": "DnaJ homolog subfamily B member 11; ER-associated DNAJ; ER-associated Hsp40 co-chaperone; Endoplasmic reticulum DNA J domain-containing protein 3", "protein_names_refseq": "dnaJ homolog subfamily B member 11", "tax_id": 9031, "disease": "", "pathway": " (gga:424868)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052540.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; As a co-chaperone for HSPA5 it is required for proper folding, trafficking or degradation of proteins. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. It is necessary for maturation and correct trafficking of PKD1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0051082 unfolded protein binding;GO:0051787 misfolded protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0101031 protein folding chaperone complex", "go_biological_process": "GO:0006457 protein folding;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RR91-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2UEL4-1", "uniprot_id": [ { "id": "A0A3Q2UEL4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2UEL4", "type": "external" } ], "mass": 101666.0, "length": 886, "protein_name": "Phosphatidylinositol 3-kinase catalytic subunit type 3", "gene_name": "PIK3C3", "organism": "Chicken", "refseq_name": "phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X4", "refseq_ac": [ { "id": "XP_040512029", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040512029", "type": "external" } ], "gene_names_uniprotkb": "PIK3C3", "gene_names_refseq": "PIK3C3", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase catalytic subunit type 3; 2.7.1.137", "protein_names_refseq": "phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X4", "tax_id": 9031, "disease": "", "pathway": " (gga:100857877); (R-GGA-1632852); (R-GGA-1660514); (R-GGA-1660516); (R-GGA-1660517); (R-GGA-5668599)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052572.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding;GO:0016303 1-phosphatidylinositol-3-kinase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005777 peroxisome", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0044829 host-mediated activation of viral genome replication;GO:0000045 autophagosome assembly;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2UEL4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F3Z1-1", "uniprot_id": [ { "id": "PYRG2_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F3Z1", "type": "external" } ], "mass": 66069.0, "length": 586, "protein_name": "CTP synthase 2", "gene_name": "CTPS2", "organism": "Chicken", "refseq_name": "CTP synthase 2", "refseq_ac": [ { "id": "NP_001025978", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025978", "type": "external" } ], "gene_names_uniprotkb": "CTPS2; RCJMB04_4c5", "gene_names_refseq": "CTPS2", "protein_names_uniprotkb": "CTP synthase 2; 6.3.4.2; CTP synthetase 2; UTP--ammonia ligase 2", "protein_names_refseq": "CTP synthase 2; CTP synthase II; CTP synthetase 2; UTP--ammonia ligase 2", "tax_id": 9031, "disease": "", "pathway": " (gga:418620); (R-GGA-499943)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15642098;23102846", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851509.1, SRR13267649.182864.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000021.1. On Aug 8, 2005 this sequence version replaced XP_416819.1., [RefSeq]; According to microarray and qRT-PCR analyses, the nucleotide metabolism-related gene CTPS2 was more highly expressed in the chicken primordial germ cells than that of stage X blastoderms., [RefSeq, PubMed]; CTP synthase involved in the de novo synthesis of CTP, a precursor of DNA, RNA and phospholipids. Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as a source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0003883 CTP synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0097268 cytoophidium", "go_biological_process": "GO:0044210 'de novo' CTP biosynthetic process;GO:0006241 CTP biosynthetic process;GO:0019856 pyrimidine nucleobase biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q5F3Z1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RQ85-1", "uniprot_id": [ { "id": "A0A1L1RQ85_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RQ85", "type": "external" } ], "mass": 37838.0, "length": 344, "protein_name": "Lysosome-associated membrane glycoprotein 5", "gene_name": "LAMP5", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LAMP5", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysosome-associated membrane glycoprotein 5; Lysosome-associated membrane protein 5", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:416732)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in short-term synaptic plasticity in a subset of GABAergic neurons in the brain., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0032584 growth cone membrane;GO:0030425 dendrite;GO:0055037 recycling endosome;GO:0031901 early endosome membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane", "go_biological_process": "GO:0072594 establishment of protein localization to organelle;GO:0099171 presynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RQ85-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2UDL9-1", "uniprot_id": [ { "id": "A0A3Q2UDL9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2UDL9", "type": "external" } ], "mass": 34885.0, "length": 297, "protein_name": "ER membrane protein complex subunit 2", "gene_name": "EMC2", "organism": "Chicken", "refseq_name": "ER membrane protein complex subunit 2", "refseq_ac": [ { "id": "NP_001185609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185609", "type": "external" } ], "gene_names_uniprotkb": "EMC2", "gene_names_refseq": "EMC2; TTC35", "protein_names_uniprotkb": "ER membrane protein complex subunit 2", "protein_names_refseq": "ER membrane protein complex subunit 2; tetratricopeptide repeat domain 35; tetratricopeptide repeat protein 35", "tax_id": 9031, "disease": "", "pathway": " (gga:420273)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: BX931995.2, HAEK01105538.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000044.1. On Nov 4, 2010 this sequence version replaced XP_418385.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments and orthologous data., [RefSeq]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032977 membrane insertase activity", "go_cellular_component": "GO:0072546 EMC complex;GO:0042406 extrinsic component of endoplasmic reticulum membrane", "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2UDL9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50460-1", "uniprot_id": [ { "id": "CSRP2_CHICK", "url": "https://www.uniprot.org/uniprot/P50460", "type": "external" } ], "mass": 20925.0, "length": 194, "protein_name": "Cysteine and glycine-rich protein 2", "gene_name": "CSRP2", "organism": "Chicken", "refseq_name": "cysteine and glycine-rich protein 2", "refseq_ac": [ { "id": "NP_990539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990539", "type": "external" } ], "gene_names_uniprotkb": "CSRP2", "gene_names_refseq": "BETA-CRP; CRP2; CSRP2", "protein_names_uniprotkb": "Cysteine and glycine-rich protein 2; Beta-CRP; Beta-cysteine-rich protein; CRP2; Cysteine-rich protein 2", "protein_names_refseq": "beta-cysteine-rich protein; cysteine and glycine-rich protein 2; cysteine-rich protein 2", "tax_id": 9031, "disease": "", "pathway": " (gga:396128)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7499425", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: FJ882406.1, BU325916.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN05341171 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000012.1., [RefSeq]; Expression of the genes encoding both CRP1 and CRP2 is differentially regulated in normal versus transformed cells, raising the possibility that members of the CRP family may function in control of cell growth and differentiation., [RefSeq, PubMed]; Totally down-regulated in transformed cells. May therefore take part in the control of cell growth and differentiation., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P50460-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2U3H4-1", "uniprot_id": [ { "id": "A0A3Q2U3H4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2U3H4", "type": "external" } ], "mass": 146349.0, "length": 1325, "protein_name": "[histone H3]-lysine(9) N-methyltransferase", "gene_name": "EHMT1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EHMT1", "gene_names_refseq": "", "protein_names_uniprotkb": "[histone H3]-lysine(9) N-methyltransferase; 2.1.1.367", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:417250); (R-GGA-2559582); (R-GGA-8953750)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.1.1.367", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.367", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0002039 p53 binding;GO:0140948 histone H3K9 monomethyltransferase activity;GO:0046974 histone H3K9 methyltransferase activity;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0005634 nucleus;GO:0016604 nuclear body;GO:0000785 chromatin", "go_biological_process": "GO:0032259 methylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0040029 epigenetic regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2U3H4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2U2M5-1", "uniprot_id": [ { "id": "A0A3Q2U2M5_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2U2M5", "type": "external" } ], "mass": 128474.0, "length": 1160, "protein_name": "Solute carrier family 12 member 4", "gene_name": "SLC12A4", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC12A4", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 12 member 4", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-426117)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015379 potassium:chloride symporter activity;GO:0005524 ATP binding;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0006884 cell volume homeostasis;GO:1902476 chloride transmembrane transport;GO:0055075 potassium ion homeostasis;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2U2M5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5F448-1", "uniprot_id": [ { "id": "GPHR_CHICK", "url": "https://www.uniprot.org/uniprot/Q5F448", "type": "external" } ], "mass": 52753.0, "length": 455, "protein_name": "Golgi pH regulator", "gene_name": "GPR89A; GPR89", "organism": "Chicken", "refseq_name": "Golgi pH regulator", "refseq_ac": [ { "id": "NP_001025962", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025962", "type": "external" } ], "gene_names_uniprotkb": "GPR89A; GPR89; GPHR; RCJMB04_3g11", "gene_names_refseq": "GPHR; GPR89A; GPR89B; GPR89", "protein_names_uniprotkb": "Golgi pH regulator; Protein GPR89", "protein_names_refseq": "G protein-coupled receptor 89B; Golgi pH regulator; protein GPR89", "tax_id": 9031, "disease": "", "pathway": " (gga:418459)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ851452.1, SRR13267649.201044.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AJ851452.1. On Aug 8, 2005 this sequence version replaced XP_416668.1., [RefSeq]; Voltage-gated channel that enables the transfer of anions such as iodide, chloride, bromide and fluoride which may function in counter-ion conductance and participates in Golgi acidification. Essential for maintaining the acidic luminal pH of the Golgi apparatus in neurons, which is important for preserving Golgi structural integrity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" } ], "go_molecular_function": "GO:0008308 voltage-gated monoatomic anion channel activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0032580 Golgi cisterna membrane;GO:0034702 monoatomic ion channel complex;GO:0030660 Golgi-associated vesicle membrane;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0030217 T cell differentiation;GO:0051452 intracellular pH reduction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5F448-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2TY05-1", "uniprot_id": [ { "id": "A0A3Q2TY05_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2TY05", "type": "external" } ], "mass": 110906.0, "length": 978, "protein_name": "Oxysterol-binding protein", "gene_name": "OSBPL6", "organism": "Chicken", "refseq_name": "oxysterol-binding protein-related protein 6 isoform X1", "refseq_ac": [ { "id": "XP_004942759", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004942759", "type": "external" } ], "gene_names_uniprotkb": "OSBPL6", "gene_names_refseq": "OSBPL6", "protein_names_uniprotkb": "Oxysterol-binding protein", "protein_names_refseq": "oxysterol-binding protein-related protein 6 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-192105)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0120015 sterol transfer activity;GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0097038 perinuclear endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006699 bile acid biosynthetic process;GO:0032374 regulation of cholesterol transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2TY05-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2TYJ2-1", "uniprot_id": [ { "id": "A0A3Q2TYJ2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2TYJ2", "type": "external" } ], "mass": 204611.0, "length": 1833, "protein_name": "Tuberin", "gene_name": "TSC2", "organism": "Chicken", "refseq_name": "tuberin isoform X1", "refseq_ac": [ { "id": "XP_015149932", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015149932", "type": "external" } ], "gene_names_uniprotkb": "TSC2", "gene_names_refseq": "TSC2", "protein_names_uniprotkb": "Tuberin", "protein_names_refseq": "tuberin isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:416552); (R-GGA-1632852); (R-GGA-165181); (R-GGA-198323); (R-GGA-380972); (R-GGA-5628897); (R-GGA-8854214)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052545.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth. Within the TSC-TBC complex, TSC2 acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. In absence of nutrients, the TSC-TBC complex inhibits mTORC1, thereby preventing phosphorylation of ribosomal protein S6 kinase (RPS6KB1 and RPS6KB2) and EIF4EBP1 (4E-BP1) by the mTORC1 signaling. The TSC-TBC complex is inactivated in response to nutrients, relieving inhibition of mTORC1. Involved in microtubule-mediated protein transport via its ability to regulate mTORC1 signaling. Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042803 protein homodimerization activity;GO:0031267 small GTPase binding;GO:0051879 Hsp90 protein binding;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0033596 TSC1-TSC2 complex;GO:0005634 nucleus;GO:0045202 synapse;GO:0005765 lysosomal membrane;GO:0005737 cytoplasm", "go_biological_process": "GO:0051056 regulation of small GTPase mediated signal transduction;GO:0016241 regulation of macroautophagy;GO:0032007 negative regulation of TOR signaling;GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0016239 positive regulation of macroautophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2TYJ2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2U8A4-1", "uniprot_id": [ { "id": "A0A3Q2U8A4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2U8A4", "type": "external" } ], "mass": 45319.0, "length": 411, "protein_name": "Calcium binding protein 1", "gene_name": "CABP1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CABP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Calcium binding protein 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:770178)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0048306 calcium-dependent protein binding;GO:0005246 calcium channel regulator activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0007601 visual perception;GO:0007602 phototransduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2U8A4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2TTY6-1", "uniprot_id": [ { "id": "A0A3Q2TTY6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2TTY6", "type": "external" } ], "mass": 395868.0, "length": 3531, "protein_name": "WD repeat and FYVE domain containing 3", "gene_name": "WDFY3", "organism": "Chicken", "refseq_name": "WD repeat and FYVE domain-containing protein 3 isoform X1", "refseq_ac": [ { "id": "XP_015131950", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015131950", "type": "external" } ], "gene_names_uniprotkb": "WDFY3", "gene_names_refseq": "WDFY3", "protein_names_uniprotkb": "WD repeat and FYVE domain containing 3", "protein_names_refseq": "WD repeat and FYVE domain-containing protein 3 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:422613)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052535.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005545 1-phosphatidylinositol binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000421 autophagosome membrane;GO:0005635 nuclear envelope;GO:0005829 cytosol;GO:0016605 PML body", "go_biological_process": "GO:0035973 aggrephagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2TTY6-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2U2R7-1", "uniprot_id": [ { "id": "A0A3Q2U2R7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2U2R7", "type": "external" } ], "mass": 61101.0, "length": 541, "protein_name": "Neuropilin and tolloid like 1", "gene_name": "NETO1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NETO1", "gene_names_refseq": "", "protein_names_uniprotkb": "Neuropilin and tolloid like 1", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:421018)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0016020 membrane;GO:1904115 axon cytoplasm;GO:0060076 excitatory synapse;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:0007613 memory;GO:0008542 visual learning;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2U2R7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2TZ01-1", "uniprot_id": [ { "id": "A0A3Q2TZ01_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2TZ01", "type": "external" } ], "mass": 57554.0, "length": 525, "protein_name": "Thymocyte selection associated high mobility group box", "gene_name": "TOX", "organism": "Chicken", "refseq_name": "thymocyte selection-associated high mobility group box protein TOX", "refseq_ac": [ { "id": "NP_001376327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001376327", "type": "external" } ], "gene_names_uniprotkb": "TOX", "gene_names_refseq": "TOX", "protein_names_uniprotkb": "Thymocyte selection associated high mobility group box", "protein_names_refseq": "thymocyte selection-associated high mobility group box protein TOX", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR13267649.155587.1, SRR13267659.309621.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN08016670 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000043.1. On Dec 18, 2020 this sequence version replaced XP_015138159.2., [RefSeq]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001779 natural killer cell differentiation;GO:0002362 CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment;GO:1902232 regulation of positive thymic T cell selection;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010976 positive regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2TZ01-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q5ZIQ3-1", "uniprot_id": [ { "id": "HNRPK_CHICK", "url": "https://www.uniprot.org/uniprot/Q5ZIQ3", "type": "external" } ], "mass": 47278.0, "length": 427, "protein_name": "Heterogeneous nuclear ribonucleoprotein K", "gene_name": "HNRNPKL; HNRNPK", "organism": "Chicken", "refseq_name": "heterogeneous nuclear ribonucleoprotein K", "refseq_ac": [ { "id": "NP_001026556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026556", "type": "external" } ], "gene_names_uniprotkb": "HNRNPKL; HNRNPK; HNRPK; RCJMB04_24e23", "gene_names_refseq": "HNRNPKL; HNRNPK; HNRPK", "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein K; hnRNP K", "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein K; hnRNP K", "tax_id": 9031, "disease": "", "pathway": " (gga:426516)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15642098", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: AJ720731.1, HAEK01004952.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992323, SAMEA103992393 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000547.1. On Aug 8, 2005 this sequence version replaced XP_424155.1., [RefSeq]; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. May play an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. As part of a ribonucleoprotein complex, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005681 spliceosomal complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0010629 negative regulation of gene expression;GO:0045892 negative regulation of DNA-templated transcription;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q5ZIQ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2TZZ7-1", "uniprot_id": [ { "id": "A0A3Q2TZZ7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2TZZ7", "type": "external" } ], "mass": 213089.0, "length": 1904, "protein_name": "Receptor-type tyrosine-protein phosphatase F", "gene_name": "PTPRF", "organism": "Chicken", "refseq_name": "receptor-type tyrosine-protein phosphatase F isoform X12", "refseq_ac": [ { "id": "XP_040534323", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040534323", "type": "external" } ], "gene_names_uniprotkb": "PTPRF", "gene_names_refseq": "PTPRF", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase F; 3.1.3.48", "protein_names_refseq": "receptor-type tyrosine-protein phosphatase F isoform X12", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-388844); (R-GGA-77387)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052580.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" } ], "go_molecular_function": "GO:0008201 heparin binding;GO:0004725 protein tyrosine phosphatase activity;GO:0050839 cell adhesion molecule binding;GO:0044877 protein-containing complex binding;GO:0035373 chondroitin sulfate proteoglycan binding", "go_cellular_component": "GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0043005 neuron projection", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007399 nervous system development;GO:0016477 cell migration;GO:0099560 synaptic membrane adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2TZZ7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53033-1", "uniprot_id": [ { "id": "RFC2_CHICK", "url": "https://www.uniprot.org/uniprot/P53033", "type": "external" } ], "mass": 39707.0, "length": 359, "protein_name": "Replication factor C subunit 2", "gene_name": "RFC2", "organism": "Chicken", "refseq_name": "replication factor C subunit 2", "refseq_ac": [ { "id": "NP_990861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_990861", "type": "external" } ], "gene_names_uniprotkb": "RFC2", "gene_names_refseq": "RFC2; RFC40", "protein_names_uniprotkb": "Replication factor C subunit 2; A1 40 kDa subunit; Activator 1 40 kDa subunit; Activator 1 subunit 2; RF-C 40 kDa subunit; RFC40; Replication factor C 40 kDa subunit", "protein_names_refseq": "A1 40 kDa subunit; RF-C 40 kDa subunit; activator 1 40 kDa subunit; activator 1 subunit 2; replication factor C (activator 1) 2, 40kDa; replication factor C 40 kDa subunit; replication factor C subunit 2; replication factor C/activator 1 subunit", "tax_id": 9031, "disease": "", "pathway": " (gga:396542); (R-GGA-110312); (R-GGA-110314); (R-GGA-110320); (R-GGA-174411); (R-GGA-176187); (R-GGA-217106); (R-GGA-351451); (R-GGA-353303); (R-GGA-5651801); (R-GGA-5655862); (R-GGA-5656121); (R-GGA-5656169); (R-GGA-5685938); (R-GGA-5685942); (R-GGA-5693537); (R-GGA-5693607); (R-GGA-5696397); (R-GGA-5696400); (R-GGA-6782135); (R-GGA-6782210); (R-GGA-69091)", "pathway_count": 22, "publication_count": 11, "publication_id_list": "10449415;11062235;12773817;15066121;15311285;15572677;15642098;17468739;17575048;1764072;8068208", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01000858.1, U12438.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JAENSK010000323.1., [RefSeq]; Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. This subunit binds ATP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0019899 enzyme binding;GO:0003689 DNA clamp loader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005663 DNA replication factor C complex;GO:0031390 Ctf18 RFC-like complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006261 DNA-templated DNA replication;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P53033-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RQA3-1", "uniprot_id": [ { "id": "A0A1L1RQA3_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RQA3", "type": "external" } ], "mass": 72723.0, "length": 651, "protein_name": "Solute carrier family 24 member 2", "gene_name": "SLC24A2", "organism": "Chicken", "refseq_name": "sodium/potassium/calcium exchanger 2 isoform 2", "refseq_ac": [ { "id": "NP_001384040", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001384040", "type": "external" } ], "gene_names_uniprotkb": "SLC24A2", "gene_names_refseq": "NCKX; SLC24A2", "protein_names_uniprotkb": "Solute carrier family 24 member 2", "protein_names_refseq": "Na(+)/K(+)/Ca(2+)-exchange protein 2; cone potassium-dependent, sodium-calcium exchanger; retinal cone Na-Ca+K exchanger; sodium/potassium/calcium exchanger 2 isoform 2; sodium/potassium/calcium exchanger 2; solute carrier family 24 (sodium/potassium/calcium exchanger), member 2", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-425561)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: SRR12888497.287783.1, SRR12888496.196462.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992533 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000093.1. On Nov 3, 2021 this sequence version replaced XP_015135569.1., [RefSeq]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005262 calcium channel activity;GO:0015293 symporter activity;GO:0008273 calcium, potassium:sodium antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0098793 presynapse", "go_biological_process": "GO:0006874 intracellular calcium ion homeostasis;GO:0060292 long-term synaptic depression;GO:0070588 calcium ion transmembrane transport;GO:0071486 cellular response to high light intensity;GO:0060291 long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RQA3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RQR8-1", "uniprot_id": [ { "id": "A0A1L1RQR8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RQR8", "type": "external" } ], "mass": 12467.0, "length": 105, "protein_name": "Synaptic plasticity regulator PANTS", "gene_name": "C22orf39", "organism": "Chicken", "refseq_name": "UPF0545 protein C22orf39 homolog", "refseq_ac": [ { "id": "XP_015131179", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015131179", "type": "external" } ], "gene_names_uniprotkb": "C22orf39", "gene_names_refseq": "C22orf39", "protein_names_uniprotkb": "Synaptic plasticity regulator PANTS; Plasticity-associated neural transcript short", "protein_names_refseq": "UPF0545 protein C22orf39 homolog", "tax_id": 9031, "disease": "", "pathway": " (gga:101751757)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052546.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0045202 synapse;GO:0043083 synaptic cleft", "go_biological_process": "GO:1900272 negative regulation of long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RQR8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RRE8-1", "uniprot_id": [ { "id": "A0A1L1RRE8_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RRE8", "type": "external" } ], "mass": 18599.0, "length": 167, "protein_name": "Adenosine 5'-monophosphoramidase HINT3", "gene_name": "HINT3", "organism": "Chicken", "refseq_name": "adenosine 5'-monophosphoramidase HINT3", "refseq_ac": [ { "id": "XP_001232866", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001232866", "type": "external" } ], "gene_names_uniprotkb": "HINT3", "gene_names_refseq": "HINT3", "protein_names_uniprotkb": "Adenosine 5'-monophosphoramidase HINT3; Histidine triad nucleotide-binding protein 3", "protein_names_refseq": "adenosine 5'-monophosphoramidase HINT3", "tax_id": 9031, "disease": "", "pathway": " (gga:769579)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052534.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "2.7.7.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.51", "type": "external" }, { "id": "3.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000166 nucleotide binding;GO:0043530 adenosine 5'-monophosphoramidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RRE8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RRH1-1", "uniprot_id": [ { "id": "A0A1L1RRH1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RRH1", "type": "external" } ], "mass": 39974.0, "length": 351, "protein_name": "G-protein coupled receptors family 1 profile domain-containing protein", "gene_name": "LOC431250", "organism": "Chicken", "refseq_name": "G-protein coupled receptor 183-like", "refseq_ac": [ { "id": "XP_025002518", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_025002518", "type": "external" } ], "gene_names_uniprotkb": "LOC431250", "gene_names_refseq": "LOC431250", "protein_names_uniprotkb": "G-protein coupled receptors family 1 profile domain-containing protein", "protein_names_refseq": "G-protein coupled receptor 183-like", "tax_id": 9031, "disease": "", "pathway": " (gga:431250)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RRH1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RRM0-1", "uniprot_id": [ { "id": "A0A1L1RRM0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RRM0", "type": "external" } ], "mass": 42898.0, "length": 391, "protein_name": "Vacuolar protein sorting-associated protein VTA1 homolog", "gene_name": "VTA1", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "VTA1", "gene_names_refseq": "", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein VTA1 homolog", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-917729)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0010008 endosome membrane;GO:0005771 multivesicular body", "go_biological_process": "GO:0015031 protein transport;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RRM0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RRN7-1", "uniprot_id": [ { "id": "A0A1L1RRN7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RRN7", "type": "external" } ], "mass": 47324.0, "length": 434, "protein_name": "phosphopyruvate hydratase", "gene_name": "ENO2", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENO2", "gene_names_refseq": "", "protein_names_uniprotkb": "phosphopyruvate hydratase; 2-phospho-D-glycerate hydro-lyase; 4.2.1.11", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (gga:395689); (R-GGA-70171); (R-GGA-70263)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1RMS4;F1NG74", "ec_number_list": [ { "id": "4.2.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.11", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004634 phosphopyruvate hydratase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043204 perikaryon;GO:0001917 photoreceptor inner segment;GO:0000015 phosphopyruvate hydratase complex", "go_biological_process": "GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RRN7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RRW4-1", "uniprot_id": [ { "id": "A0A1L1RRW4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RRW4", "type": "external" } ], "mass": 54859.0, "length": 513, "protein_name": "Transcription factor like 5", "gene_name": "TCFL5", "organism": "Chicken", "refseq_name": "transcription factor-like 5 protein isoform X1", "refseq_ac": [ { "id": "XP_001234727", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_001234727", "type": "external" } ], "gene_names_uniprotkb": "TCFL5", "gene_names_refseq": "TCFL5", "protein_names_uniprotkb": "Transcription factor like 5", "protein_names_refseq": "transcription factor-like 5 protein isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:771446)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052551.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 4, 2016 this sequence version replaced XP_001234727.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001673 male germ cell nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0042127 regulation of cell population proliferation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RRW4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RRY6-1", "uniprot_id": [ { "id": "A0A1L1RRY6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RRY6", "type": "external" } ], "mass": 54879.0, "length": 496, "protein_name": "THUMP domain containing 3", "gene_name": "THUMPD3", "organism": "Chicken", "refseq_name": "THUMP domain-containing protein 3 isoform X1", "refseq_ac": [ { "id": "XP_414446", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_414446", "type": "external" } ], "gene_names_uniprotkb": "THUMPD3", "gene_names_refseq": "THUMPD3", "protein_names_uniprotkb": "THUMP domain containing 3", "protein_names_refseq": "THUMP domain-containing protein 3 isoform X1", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052543.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_414446.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016423 tRNA (guanine) methyltransferase activity;GO:0003723 RNA binding;GO:0160117 tRNA (guanine(6)-N2)-methyltransferase activity;GO:0160118 tRNA (guanine(7)-N2)-methyltransferase activity;GO:0008173 RNA methyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0043527 tRNA methyltransferase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0030488 tRNA methylation;GO:0008033 tRNA processing;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RRY6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RSD2-1", "uniprot_id": [ { "id": "A0A1L1RSD2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RSD2", "type": "external" } ], "mass": 75906.0, "length": 670, "protein_name": "Beta-glucuronidase", "gene_name": "GUSB", "organism": "Chicken", "refseq_name": "beta-glucuronidase isoform X1", "refseq_ac": [ { "id": "XP_015151296", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015151296", "type": "external" } ], "gene_names_uniprotkb": "GUSB", "gene_names_refseq": "GUSB; beta-glucuronidase", "protein_names_uniprotkb": "Beta-glucuronidase; 3.2.1.31", "protein_names_refseq": "beta-glucuronidase isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2024101); (R-GGA-2160916); (R-GGA-6798695)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052550.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Plays an important role in the degradation of dermatan and keratan sulfates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "1.11.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.24", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.4.21.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.31", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.1", "type": "external" }, { "id": "2.3.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "3.1.6.8", "url": 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"https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.5.4.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.5", "type": "external" }, { "id": "2.7.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "3.4.14.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.2", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.5.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.6", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "5.4.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" } ], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019904 protein domain specific binding;GO:0030246 carbohydrate binding;GO:0004566 beta-glucuronidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0043202 lysosomal lumen;GO:0005764 lysosome", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0030207 chondroitin sulfate proteoglycan catabolic process;GO:0030200 heparan sulfate proteoglycan catabolic process;GO:0030214 hyaluronan catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RSD2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RSD4-1", "uniprot_id": [ { "id": "A0A1L1RSD4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RSD4", "type": "external" } ], "mass": 45385.0, "length": 412, "protein_name": "Protein farnesyltransferase subunit beta", "gene_name": "FNTB", "organism": "Chicken", "refseq_name": "farnesyltransferase, CAAX box, beta", "refseq_ac": [ { "id": "NP_001383594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383594", "type": "external" } ], "gene_names_uniprotkb": "FNTB", "gene_names_refseq": "FNTB", "protein_names_uniprotkb": "Protein farnesyltransferase subunit beta; 2.5.1.58; FTase-beta", "protein_names_refseq": "farnesyltransferase, CAAX box, beta", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-9648002); (R-GGA-9953170)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEL01005791.1, HAEK01187358.1 [ECO:0000332] RNAseq introns :: mixed sample support SAMEA103992290, SAMEA103992323 [ECO:0006172] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HAEL01005791.1, JAENSK010000212.1, CR387309.1 and HAEK01027120.1. On or before Oct 25, 2021 this sequence version replaced XP_025006977.1, XP_040528483.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments., [RefSeq]; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding., [UniProtKB, UniProtKB]; Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0004660 protein farnesyltransferase activity;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0010698 acetyltransferase activator activity", "go_cellular_component": "GO:0005965 protein farnesyltransferase complex;GO:0005875 microtubule associated complex", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0060632 regulation of microtubule-based movement;GO:0097354 prenylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RSD4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RT22-1", "uniprot_id": [ { "id": "A0A1L1RT22_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RT22", "type": "external" } ], "mass": 151157.0, "length": 1323, "protein_name": "DENN domain containing 5A", "gene_name": "DENND5A", "organism": "Chicken", "refseq_name": "DENN domain-containing protein 5A isoform X1", "refseq_ac": [ { "id": "XP_015141954", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015141954", "type": "external" } ], "gene_names_uniprotkb": "DENND5A", "gene_names_refseq": "DENND5A", "protein_names_uniprotkb": "DENN domain containing 5A", "protein_names_refseq": "DENN domain-containing protein 5A isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:423048); (R-GGA-8876198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052536.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005802 trans-Golgi network;GO:0030904 retromer complex;GO:0016020 membrane", "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RT22-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RT94-1", "uniprot_id": [ { "id": "A0A1L1RT94_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RT94", "type": "external" } ], "mass": 19797.0, "length": 176, "protein_name": "Large ribosomal subunit protein eL31", "gene_name": "RPL31", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RPL31", "gene_names_refseq": "", "protein_names_uniprotkb": "Large ribosomal subunit protein eL31; 60S ribosomal protein L31", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-1799339); (R-GGA-72706); (R-GGA-975956); (R-GGA-975957); (R-GGA-9954709); (R-GGA-9954714); (R-GGA-9954716)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "38395592", "class_list": "", "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0045202 synapse;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0A1L1RT94-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RTK2-1", "uniprot_id": [ { "id": "A0A1L1RTK2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RTK2", "type": "external" } ], "mass": 44749.0, "length": 410, "protein_name": "Torsin family 1 member B", "gene_name": "TOR1B", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TOR1B", "gene_names_refseq": "", "protein_names_uniprotkb": "Torsin family 1 member B", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-8856825)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0034504 protein localization to nucleus;GO:0007029 endoplasmic reticulum organization;GO:0071763 nuclear membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RTK2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RTQ1-1", "uniprot_id": [ { "id": "A0A1L1RTQ1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RTQ1", "type": "external" } ], "mass": 75937.0, "length": 667, "protein_name": "Arachidonate 15-lipoxygenase type B", "gene_name": "ALOX15B", "organism": "Chicken", "refseq_name": "hydroperoxide isomerase ALOXE3", "refseq_ac": [ { "id": "XP_046775454", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046775454", "type": "external" } ], "gene_names_uniprotkb": "ALOX15B", "gene_names_refseq": "ALOX15B", "protein_names_uniprotkb": "Arachidonate 15-lipoxygenase type B", "protein_names_refseq": "hydroperoxide isomerase ALOXE3", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2142712); (R-GGA-2142770)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 1% of CDS bases ##RefSeq-Attributes-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052577.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0034440 lipid oxidation;GO:0019372 lipoxygenase pathway;GO:0019369 arachidonate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RTQ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RTV6-1", "uniprot_id": [ { "id": "A0A1L1RTV6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RTV6", "type": "external" } ], "mass": 35064.0, "length": 315, "protein_name": "Olfactory receptor", "gene_name": "LOC769317", "organism": "Chicken", "refseq_name": "olfactory receptor 52R1-like", "refseq_ac": [ { "id": "XP_004949864", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_004949864", "type": "external" } ], "gene_names_uniprotkb": "LOC769317", "gene_names_refseq": "LOC769317", "protein_names_uniprotkb": "Olfactory receptor", "protein_names_refseq": "olfactory receptor 52R1-like", "tax_id": 9031, "disease": "", "pathway": " (gga:769317)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052532.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Odorant receptor., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0004984 olfactory receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RTV6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RUB9-1", "uniprot_id": [ { "id": "A0A1L1RUB9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RUB9", "type": "external" } ], "mass": 39723.0, "length": 362, "protein_name": "Replication factor C subunit 4", "gene_name": "RFC4", "organism": "Chicken", "refseq_name": "replication factor C subunit 4 isoform X1", "refseq_ac": [ { "id": "XP_046754381", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_046754381", "type": "external" } ], "gene_names_uniprotkb": "RFC4", "gene_names_refseq": "RFC4", "protein_names_uniprotkb": "Replication factor C subunit 4; Activator 1 subunit 4", "protein_names_refseq": "replication factor C subunit 4 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-110312); (R-GGA-110314); (R-GGA-110320); (R-GGA-174411); (R-GGA-176187); (R-GGA-5651801); (R-GGA-5655862); (R-GGA-5656121); (R-GGA-5656169); (R-GGA-5685938); (R-GGA-5685942); (R-GGA-5693537); (R-GGA-5693607); (R-GGA-5696397); (R-GGA-5696400); (R-GGA-6782135); (R-GGA-6782210); (R-GGA-69091)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052540.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Subunit of the replication factor C (RFC) complex which acts during elongation of primed DNA templates by DNA polymerases delta and epsilon, and is necessary for ATP-dependent loading of proliferating cell nuclear antigen (PCNA) onto primed DNA. The RFC4 subunit probably functions as a scaffold on which the other complex components can assemble., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003689 DNA clamp loader activity;GO:0017116 single-stranded DNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031390 Ctf18 RFC-like complex;GO:0031391 Elg1 RFC-like complex;GO:0005663 DNA replication factor C complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006261 DNA-templated DNA replication;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RUB9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RUN2-1", "uniprot_id": [ { "id": "A0A1L1RUN2_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RUN2", "type": "external" } ], "mass": 21340.0, "length": 205, "protein_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "gene_name": "ATP6V0B", "organism": "Chicken", "refseq_name": "V-type proton ATPase 21 kDa proteolipid subunit c''", "refseq_ac": [ { "id": "NP_001264501", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264501", "type": "external" } ], "gene_names_uniprotkb": "ATP6V0B", "gene_names_refseq": "ATP6V0B", "protein_names_uniprotkb": "V-type proton ATPase 21 kDa proteolipid subunit c''; Vacuolar proton pump 21 kDa proteolipid subunit c''", "protein_names_refseq": "ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b; V-type proton ATPase 21 kDa proteolipid subunit c''", "tax_id": 9031, "disease": "", "pathway": " (gga:424575); (R-GGA-1222556); (R-GGA-77387); (R-GGA-917977); (R-GGA-9639288)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: CR407484.1, HAEK01188254.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000239.1. On Apr 12, 2013 this sequence version replaced XP_003641751.1., [RefSeq]; Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB]; Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005768 endosome;GO:0016020 membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0033179 proton-transporting V-type ATPase, V0 domain", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RUN2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A3Q2TYJ1-1", "uniprot_id": [ { "id": "A0A3Q2TYJ1_CHICK", "url": "https://www.uniprot.org/uniprot/A0A3Q2TYJ1", "type": "external" } ], "mass": 43623.0, "length": 377, "protein_name": "Cytokine receptor-like factor 2", "gene_name": "CRLF2", "organism": "Chicken", "refseq_name": "cytokine receptor-like factor 2 isoform X1", "refseq_ac": [ { "id": "XP_040517067", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_040517067", "type": "external" } ], "gene_names_uniprotkb": "CRLF2", "gene_names_refseq": "CRLF2", "protein_names_uniprotkb": "Cytokine receptor-like factor 2; Thymic stromal lymphopoietin protein receptor", "protein_names_refseq": "cytokine receptor-like factor 2 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:418668)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052573.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]; Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2. Implicated in the development of the hematopoietic system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005143 interleukin-12 receptor binding;GO:0042164 interleukin-12 alpha subunit binding;GO:0015026 coreceptor activity;GO:0004896 cytokine receptor activity", "go_cellular_component": "GO:0016020 membrane;GO:0043514 interleukin-12 complex", "go_biological_process": "GO:0032754 positive regulation of interleukin-5 production;GO:0008284 positive regulation of cell population proliferation;GO:0035722 interleukin-12-mediated signaling pathway;GO:0033005 positive regulation of mast cell activation;GO:1904894 positive regulation of receptor signaling pathway via STAT", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A3Q2TYJ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RUW7-1", "uniprot_id": [ { "id": "A0A1L1RUW7_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RUW7", "type": "external" } ], "mass": 20210.0, "length": 187, "protein_name": "Deoxyuridine 5'-triphosphate nucleotidohydrolase", "gene_name": "DUT", "organism": "Chicken", "refseq_name": "deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 2", "refseq_ac": [ { "id": "NP_001383138", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001383138", "type": "external" } ], "gene_names_uniprotkb": "DUT", "gene_names_refseq": "DUT", "protein_names_uniprotkb": "Deoxyuridine 5'-triphosphate nucleotidohydrolase; 3.6.1.23; dUTP pyrophosphatase; dUTPase", "protein_names_refseq": "dUTP pyrophosphatase; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 2; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-499943)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01002461.1, ERR2368565.328967.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000245.1. On Oct 4, 2021 this sequence version replaced XP_025009642.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis. Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor. Essential for embryonic development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.23", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004170 dUTP diphosphatase activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006226 dUMP biosynthetic process;GO:0006231 dTMP biosynthetic process;GO:0046081 dUTP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RUW7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RVM4-1", "uniprot_id": [ { "id": "A0A1L1RVM4_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RVM4", "type": "external" } ], "mass": 9285.0, "length": 83, "protein_name": "Protein AF1q", "gene_name": "MLLT11", "organism": "Chicken", "refseq_name": "protein AF1q", "refseq_ac": [ { "id": "XP_003642733", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003642733", "type": "external" } ], "gene_names_uniprotkb": "MLLT11", "gene_names_refseq": "MLLT11", "protein_names_uniprotkb": "Protein AF1q", "protein_names_refseq": "protein AF1q", "tax_id": 9031, "disease": "", "pathway": " (gga:395847)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052556.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0097191 extrinsic apoptotic signaling pathway;GO:0090200 positive regulation of release of cytochrome c from mitochondria;GO:0097193 intrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RVM4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RW10-1", "uniprot_id": [ { "id": "A0A1L1RW10_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RW10", "type": "external" } ], "mass": 79289.0, "length": 696, "protein_name": "SEC14 and spectrin domain containing 1", "gene_name": "SESTD1", "organism": "Chicken", "refseq_name": "SEC14 domain and spectrin repeat-containing protein 1 isoform X1", "refseq_ac": [ { "id": "XP_015145048", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015145048", "type": "external" } ], "gene_names_uniprotkb": "SESTD1", "gene_names_refseq": "SESTD1", "protein_names_uniprotkb": "SEC14 and spectrin domain containing 1", "protein_names_refseq": "SEC14 domain and spectrin repeat-containing protein 1 isoform X1", "tax_id": 9031, "disease": "", "pathway": " (gga:424125)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052538.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A0A1L1RXE1", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding", "go_cellular_component": "GO:0045111 intermediate filament cytoskeleton;GO:0034704 calcium channel complex", "go_biological_process": "GO:1904878 negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RW10-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RW56-1", "uniprot_id": [ { "id": "A0A1L1RW56_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RW56", "type": "external" } ], "mass": 86901.0, "length": 760, "protein_name": "Hexosyltransferase", "gene_name": "CHPF2", "organism": "Chicken", "refseq_name": "chondroitin sulfate glucuronyltransferase", "refseq_ac": [ { "id": "XP_423717", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_423717", "type": "external" } ], "gene_names_uniprotkb": "CHPF2", "gene_names_refseq": "CHPF2", "protein_names_uniprotkb": "Hexosyltransferase; 2.4.1.-", "protein_names_refseq": "chondroitin sulfate glucuronyltransferase", "tax_id": 9031, "disease": "", "pathway": " (gga:426039); (R-GGA-2022870)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052533.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 16, 2011 this sequence version replaced XP_423717.2. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" } ], "go_molecular_function": "GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity;GO:0047238 glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0050650 chondroitin sulfate proteoglycan biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RW56-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RWF6-1", "uniprot_id": [ { "id": "A0A1L1RWF6_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RWF6", "type": "external" } ], "mass": 36610.0, "length": 331, "protein_name": "Calponin", "gene_name": "CNN3", "organism": "Chicken", "refseq_name": "calponin-3", "refseq_ac": [ { "id": "NP_001341600", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001341600", "type": "external" } ], "gene_names_uniprotkb": "CNN3", "gene_names_refseq": "CNN3; calponin-3", "protein_names_uniprotkb": "Calponin", "protein_names_refseq": "calponin 3, acidic; calponin-3", "tax_id": 9031, "disease": "", "pathway": " (gga:424485)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01000413.1, HAEL01000056.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992290, SAMEA103992323 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000239.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments., [RefSeq]; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005829 cytosol;GO:0015629 actin cytoskeleton", "go_biological_process": "GO:0007015 actin filament organization;GO:0030855 epithelial cell differentiation;GO:0031032 actomyosin structure organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RWF6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RWI9-1", "uniprot_id": [ { "id": "A0A1L1RWI9_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RWI9", "type": "external" } ], "mass": 40665.0, "length": 366, "protein_name": "Calcium/calmodulin-dependent protein kinase type IV", "gene_name": "CAMK4", "organism": "Chicken", "refseq_name": "calcium/calmodulin-dependent protein kinase type IV", "refseq_ac": [ { "id": "NP_001384162", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001384162", "type": "external" } ], "gene_names_uniprotkb": "CAMK4", "gene_names_refseq": "CAMK4", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type IV; 2.7.11.17; CaM kinase-GR", "protein_names_refseq": "calcium/calmodulin-dependent protein kinase type IV", "tax_id": 9031, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Evidence-Data-START## Transcript exon combination :: HAEK01009982.1, HAEK01057692.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA103992533 [ECO:0000348] ##Evidence-Data-END## VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from JAENSK010000095.1., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" } ], "go_molecular_function": "GO:0009931 calcium-dependent protein serine/threonine kinase activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0006954 inflammatory response;GO:0035556 intracellular signal transduction;GO:0045893 positive regulation of DNA-templated transcription;GO:0002250 adaptive immune response;GO:0007616 long-term memory", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RWI9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RWR0-1", "uniprot_id": [ { "id": "A0A1L1RWR0_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RWR0", "type": "external" } ], "mass": 16083.0, "length": 147, "protein_name": "Transthyretin", "gene_name": "LOC112531842", "organism": "Chicken", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC112531842", "gene_names_refseq": "", "protein_names_uniprotkb": "Transthyretin", "protein_names_refseq": "", "tax_id": 9031, "disease": "", "pathway": " (R-GGA-2453902); (R-GGA-6798695); (R-GGA-975634)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0070324 thyroid hormone binding;GO:0005179 hormone activity;GO:0140313 molecular sequestering activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001523 retinoid metabolic process;GO:0006144 purine nucleobase metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RWR0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A1L1RX26-1", "uniprot_id": [ { "id": "A0A1L1RX26_CHICK", "url": "https://www.uniprot.org/uniprot/A0A1L1RX26", "type": "external" } ], "mass": 49031.0, "length": 437, "protein_name": "Eukaryotic peptide chain release factor subunit 1", "gene_name": "ETF1", "organism": "Chicken", "refseq_name": "eukaryotic peptide chain release factor subunit 1", "refseq_ac": [ { "id": "XP_414511", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_414511", "type": "external" } ], "gene_names_uniprotkb": "ETF1", "gene_names_refseq": "ETF1", "protein_names_uniprotkb": "Eukaryotic peptide chain release factor subunit 1", "protein_names_refseq": "eukaryotic peptide chain release factor subunit 1", "tax_id": 9031, "disease": "", "pathway": " (gga:416182); (R-GGA-9629569); (R-GGA-975956); (R-GGA-975957)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Gallus gallus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 9.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_052544.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Nov 16, 2006 this sequence version replaced XP_414511.1. COMPLETENESS: full length., [RefSeq]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003747 translation release factor activity;GO:0004045 peptidyl-tRNA hydrolase activity;GO:1990825 sequence-specific mRNA binding;GO:0016149 translation release factor activity, codon specific", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm;GO:0018444 translation release factor complex;GO:0022626 cytosolic ribosome", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0006449 regulation of translational termination;GO:0002184 cytoplasmic translational termination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A1L1RX26-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.000100000000000000.0000000000000.000.00000", "kg_view_protein": true } ]