[ { "uniprot_canonical_ac": "P20288-1", "uniprot_id": [ { "id": "DRD2_BOVIN", "url": "https://www.uniprot.org/uniprot/P20288", "type": "external" } ], "mass": 50672.0, "length": 444, "protein_name": "D(2) dopamine receptor", "gene_name": "DRD2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DRD2", "gene_names_refseq": "", "protein_names_uniprotkb": "D(2) dopamine receptor; Dopamine D2 receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281126)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "2137198", "class_list": "", "function": "Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001591 dopamine neurotransmitter receptor activity, coupled via Gi/Go;GO:0004930 G protein-coupled receptor activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0060158 phospholipase C-activating dopamine receptor signaling pathway;GO:1990384 hyaloid vascular plexus regression;GO:0014059 regulation of dopamine secretion;GO:0051967 negative regulation of synaptic transmission, glutamatergic;GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P20288-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20414-1", "uniprot_id": [ { "id": "TIMP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P20414", "type": "external" } ], "mass": 23032.0, "length": 207, "protein_name": "Metalloproteinase inhibitor 1", "gene_name": "TIMP1", "organism": "Bovine", "refseq_name": "metalloproteinase inhibitor 1 precursor", "refseq_ac": [ { "id": "NP_776896", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776896", "type": "external" } ], "gene_names_uniprotkb": "TIMP1", "gene_names_refseq": "TIMP1", "protein_names_uniprotkb": "Metalloproteinase inhibitor 1; EG-1; Embryogenin-1; TIMP-1; Tissue inhibitor of metalloproteinases 1", "protein_names_refseq": "EG-1; TIMP-1; embryogenin-1; metalloproteinase inhibitor 1 precursor; metalloproteinase inhibitor 1; tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor); tissue inhibitor of metalloproteinases 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282092)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "12606436;15026182;16019435;20578063;21328105;2393392;2551903;8199264;8417953", "class_list": "", "function": "Analysis of species specificity of human and bovine TIMP-1 binding to mouse TIMP-1 receptor, [RefSeq, PubMed]; Decreased MMP-9 and increased TIMP-1 expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle. Erratum:[Anim Biotechnol. 2011 Apr;22(2):118], [RefSeq, PubMed]; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling., [UniProtKB, PubMed, PubMed]; Production of TIMP-1 was augmented by IL-1alpha, TNFalpha, and hepatocyte growth factor at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 mRNA was not affected by any treatments., [RefSeq, PubMed]; We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF on MMP-9 and TIMP-1 expression by semiquantitative RT-PCR and MMP activity by zymography., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3T098;Q53ZP2;Q9TVB0", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0008284 positive regulation of cell population proliferation;GO:0043086 negative regulation of catalytic activity;GO:0034097 response to cytokine;GO:0009725 response to hormone", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P20414-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20456-1", "uniprot_id": [ { "id": "IMPA1_BOVIN", "url": "https://www.uniprot.org/uniprot/P20456", "type": "external" } ], "mass": 30056.0, "length": 277, "protein_name": "Inositol monophosphatase 1", "gene_name": "IMPA1", "organism": "Bovine", "refseq_name": "inositol monophosphatase 1", "refseq_ac": [ { "id": "NP_776786", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776786", "type": "external" } ], "gene_names_uniprotkb": "IMPA1; IMPA", "gene_names_refseq": "IMPA1", "protein_names_uniprotkb": "Inositol monophosphatase 1; 3.1.3.25; 3.1.3.94; D-galactose 1-phosphate phosphatase; IMP 1; IMPase 1; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1", "protein_names_refseq": "D-galactose 1-phosphate phosphatase; IMP 1; IMPase 1; inositol monophosphatase 1; inositol(myo)-1(or 4)-monophosphatase 1; inositol-1(or 4)-monophosphatase 1; lithium-sensitive myo-inositol monophosphatase A1", "tax_id": 9913, "disease": "", "pathway": " (bta:281865); (R-BTA-1855183)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15858264;1690719;9462881", "class_list": "", "function": "Phosphatase involved in the dephosphorylation of myo-inositol monophosphate to generate myo-inositol (PubMed:9462881). Is also able to dephosphorylate scyllo-inositol-phosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-1,3-diphosphate and scyllo-inositol-1,4-diphosphate (By similarity). Also dephosphorylates in vitro other sugar-phosphates including D-galactose-1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate and 2'-AMP (PubMed:9462881). Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides, and involved in maintaining normal brain function. Has been implicated as the pharmacological target for lithium Li(+) action in brain (By similarity). Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate (PubMed:9462881)., [UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17QE4", "ec_number_list": [ { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.1.3.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.25", "type": "external" }, { "id": "3.1.3.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.9", "type": "external" }, { "id": "3.1.3.94", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.94", "type": "external" } ], "go_molecular_function": "GO:0031403 lithium ion binding;GO:0052834 inositol monophosphate phosphatase activity;GO:0000287 magnesium ion binding;GO:0030145 manganese ion binding;GO:0008934 inositol monophosphate 1-phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006020 inositol metabolic process;GO:0007165 signal transduction;GO:0006021 inositol biosynthetic process;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P20456-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20488-1", "uniprot_id": [ { "id": "SYPH_BOVIN", "url": "https://www.uniprot.org/uniprot/P20488", "type": "external" } ], "mass": 33910.0, "length": 313, "protein_name": "Synaptophysin", "gene_name": "SYP", "organism": "Bovine", "refseq_name": "synaptophysin", "refseq_ac": [ { "id": "NP_776388", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776388", "type": "external" } ], "gene_names_uniprotkb": "SYP", "gene_names_refseq": "SYP", "protein_names_uniprotkb": "Synaptophysin; Major synaptic vesicle protein p38", "protein_names_refseq": "major synaptic vesicle protein p38; synaptophysin", "tax_id": 9913, "disease": "", "pathway": " (bta:280937)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "17562317;2492017", "class_list": "", "function": "Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)., [UniProtKB]; The structure of SYP has been determined., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0051020 GTPase binding", "go_cellular_component": "GO:0048786 presynaptic active zone;GO:0030136 clathrin-coated vesicle;GO:0043005 neuron projection;GO:0030672 synaptic vesicle membrane;GO:0042584 chromaffin granule membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0048168 regulation of neuronal synaptic plasticity;GO:0045920 negative regulation of exocytosis;GO:2000474 regulation of opioid receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P20488-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P20959-1", "uniprot_id": [ { "id": "IBP3_BOVIN", "url": "https://www.uniprot.org/uniprot/P20959", "type": "external" } ], "mass": 31570.0, "length": 291, "protein_name": "Insulin-like growth factor-binding protein 3", "gene_name": "IGFBP3", "organism": "Bovine", "refseq_name": "insulin-like growth factor-binding protein 3 precursor", "refseq_ac": [ { "id": "NP_776981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776981", "type": "external" } ], "gene_names_uniprotkb": "IGFBP3", "gene_names_refseq": "IGFBP-3; IGFBP3", "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; IGFBP-3", "protein_names_refseq": "IBP-3; IGF-binding protein 3; Insulin like growth factor binding protein-3; insulin-like growth factor-binding protein 3 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:282261); (R-BTA-381426); (R-BTA-6803211); (R-BTA-8957275)", "pathway_count": 4, "publication_count": 9, "publication_id_list": "12912978;1701128;1711841;21940120;26340041;28003146;31547834;9202228;9363609", "class_list": "", "function": "Comparative analysis of IGFBP-3 gene sequence in Egyptian sheep, cattle, and buffalo shows substantial degree of homology. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis. Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1. Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade. In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis., [UniProtKB, UniProtKB]; The present study suggests that the insulin like growth factor (IGF) system or imbalances between IGF and IGF binding proteins may be involved in cystic ovary disease of cattle., [RefSeq, PubMed]; The study demonstrates that hyaluronan acts as an anti-inflammatory molecule by down-regulating IFNAR1 and IFNAR2, the signaling molecules STAT1, STAT2, JAK1 and the downstream apoptotic targets IGFBP3 and IFIT3., [RefSeq, PubMed]; These data suggest that endogenous IGFBP-3 plays a role in intrinsic apoptosis by facilitating phosphorylation and nuclear export of Nur77 to the cytoplasm where it exerts its apoptotic effect., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "A6QPI3;Q9GJV5", "ec_number_list": [], "go_molecular_function": "GO:0001968 fibronectin binding;GO:0008160 protein tyrosine phosphatase activator activity;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0042567 insulin-like growth factor ternary complex", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0032868 response to insulin;GO:0014912 negative regulation of smooth muscle cell migration;GO:0048662 negative regulation of smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P20959-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21398-1", "uniprot_id": [ { "id": "AOFA_BOVIN", "url": "https://www.uniprot.org/uniprot/P21398", "type": "external" } ], "mass": 59758.0, "length": 527, "protein_name": "Amine oxidase [flavin-containing] A", "gene_name": "MAOA", "organism": "Bovine", "refseq_name": "amine oxidase [flavin-containing] A", "refseq_ac": [ { "id": "NP_851357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851357", "type": "external" } ], "gene_names_uniprotkb": "MAOA", "gene_names_refseq": "MAOA", "protein_names_uniprotkb": "Amine oxidase [flavin-containing] A; 1.4.3.21; 1.4.3.4; MAO-A; Monoamine oxidase type A", "protein_names_refseq": "MAO-A; amine oxidase [flavin-containing] A; monoamine oxidase type A", "tax_id": 9913, "disease": "", "pathway": " (bta:281293); (R-BTA-141333); (R-BTA-181430); (R-BTA-379397); (R-BTA-379398); (R-BTA-379401); (R-BTA-380612)", "pathway_count": 7, "publication_count": 4, "publication_id_list": "17886268;20578062;2719656;31633208", "class_list": "", "function": "A polymorphism consisting of a variable number of tandem repeats in the MAOA gene promoter was associated with aggressive behavior, [RefSeq, PubMed]; Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. Preferentially oxidizes serotonin. Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline., [UniProtKB, UniProtKB]; MAOA was seriously demethylated or showed aberrant methylation patterns in four aborted clones., [RefSeq, PubMed]; Two pools of ten bovine embryos, comprised of the 4-, 8- to 16-cell, morula, blastocyst, and expanded blastocyst stages, were collected. Total RNA was isolated, and the RT-PCR-RFLP technique was used to observe expression of the MAOA gene., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0IIE7", "ec_number_list": [ { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "1.4.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.21", "type": "external" }, { "id": "1.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.4", "type": "external" } ], "go_molecular_function": "GO:0097621 monoamine oxidase activity;GO:0008131 primary methylamine oxidase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0042428 serotonin metabolic process;GO:0006584 catecholamine metabolic process;GO:0019607 phenylethylamine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P21398-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P21782-1", "uniprot_id": [ { "id": "PTN_BOVIN", "url": "https://www.uniprot.org/uniprot/P21782", "type": "external" } ], "mass": 18902.0, "length": 168, "protein_name": "Pleiotrophin", "gene_name": "PTN", "organism": "Bovine", "refseq_name": "pleiotrophin precursor", "refseq_ac": [ { "id": "NP_776380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776380", "type": "external" } ], "gene_names_uniprotkb": "PTN", "gene_names_refseq": "PTN", "protein_names_uniprotkb": "Pleiotrophin; HB-GAM; HBBM; HBGF-8; Heparin-binding brain mitogen; Heparin-binding growth factor 8; Heparin-binding growth-associated molecule; Heparin-binding neurite-promoting factor; PTN; p18", "protein_names_refseq": "HB-GAM; HBBM; HBGF-8; heparin binding growth factor 8; heparin-binding brain mitogen; heparin-binding growth-associated molecule; heparin-binding neurite-promoting factor; neurite growth-promoting factor 1; p18; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1); pleiotrophin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280904); (R-BTA-201556); (R-BTA-9851151)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "1550956;2229039;2270483;2610682;8484780", "class_list": "", "function": "Secreted growth factor that mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptor via their chondroitin sulfate (CS) groups. Thereby regulates many processes like cell proliferation, cell survival, cell growth, cell differentiation and cell migration in several tissues namely neuron and bone (By similarity) (PubMed:1550956). Also plays a role in synaptic plasticity and learning-related behavior by inhibiting long-term synaptic potentiation (By similarity). Binds PTPRZ1, leading to neutralization of the negative charges of the CS chains of PTPRZ1, inducing PTPRZ1 clustering, thereby causing the dimerization and inactivation of its phosphatase activity leading to increased tyrosine phosphorylation of each of the PTPRZ1 substrates like ALK, CTNNB1 or AFAP1L2 in order to activate the PI3K-AKT pathway. Through PTPRZ1 binding controls oligodendrocyte precursor cell differentiation by enhancing the phosphorylation of AFAP1L2 in order to activate the PI3K-AKT pathway. Forms a complex with PTPRZ1 and integrin alpha-V/beta-3 (ITGAV:ITGB3) that stimulates endothelial cell migration through SRC dephosphorylation and activation that consequently leads to ITGB3 'Tyr-773' phosphorylation (By similarity). In adult hippocampus promotes dendritic arborization, spine development, and functional integration and connectivity of newborn granule neurons through ALK by activating AKT signaling pathway (By similarity). Binds GPC2 and chondroitin sulfate proteoglycans (CSPGs) at the neuron surface, leading to abrogation of binding between PTPRS and CSPGs and neurite outgrowth promotion. Binds SDC3 and mediates bone formation by recruiting and attaching osteoblasts/osteoblast precursors to the sites for new bone deposition (By similarity). Binds ALK and promotes cell survival and cell proliferation through MAPK pathway activation (By similarity). Inhibits proliferation and enhances differentiation of neural stem cells by inhibiting FGF2-induced fibroblast growth factor receptor signaling pathway. Mediates regulatory mechanisms in normal hemostasis and in hematopoietic regeneration and in maintaining the balance of myeloid and lymphoid regeneration. In addition may play a role in the female reproductive system, auditory response and the progesterone-induced decidualization pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P20157;Q3SZU1", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0008083 growth factor activity;GO:0035374 chondroitin sulfate binding;GO:0004864 protein phosphatase inhibitor activity;GO:0005178 integrin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005783 endoplasmic reticulum;GO:0032991 protein-containing complex", "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:0048680 positive regulation of axon regeneration;GO:0007229 integrin-mediated signaling pathway;GO:0007612 learning;GO:0007613 memory", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P21782-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P22300-1", "uniprot_id": [ { "id": "GBRG2_BOVIN", "url": "https://www.uniprot.org/uniprot/P22300", "type": "external" } ], "mass": 55265.0, "length": 475, "protein_name": "Gamma-aminobutyric acid receptor subunit gamma-2", "gene_name": "GABRG2", "organism": "Bovine", "refseq_name": "gamma-aminobutyric acid receptor subunit gamma-2 precursor", "refseq_ac": [ { "id": "NP_776970", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776970", "type": "external" } ], "gene_names_uniprotkb": "GABRG2", "gene_names_refseq": "GABRG2", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit gamma-2; GABA(A) receptor subunit gamma-2; GABAAR subunit gamma-2", "protein_names_refseq": "GABA(A) receptor subunit gamma-2; GABAAR subunit gamma-2; gamma-aminobutyric acid (GABA) A receptor, gamma 2; gamma-aminobutyric acid receptor subunit gamma-2 precursor; gamma-aminobutyric acid receptor subunit gamma-2; gamma-aminobutyric acid type A receptor gamma2 subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:282240)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1702226", "class_list": "", "function": "Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity). Extrasynaptic gamma-2-containing receptors contribute to the tonic GABAergic inhibition (By similarity). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0071420 cellular response to histamine;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P22300-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23196-1", "uniprot_id": [ { "id": "APEX1_BOVIN", "url": "https://www.uniprot.org/uniprot/P23196", "type": "external" } ], "mass": 35570.0, "length": 318, "protein_name": "DNA repair nuclease/redox regulator APEX1", "gene_name": "APEX1", "organism": "Bovine", "refseq_name": "DNA repair nuclease/redox regulator APEX1", "refseq_ac": [ { "id": "NP_788782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788782", "type": "external" } ], "gene_names_uniprotkb": "APEX1; APEX; APE; BAP1; REF1", "gene_names_refseq": "APEN; APEX1; BAP1; REF-1", "protein_names_uniprotkb": "DNA repair nuclease/redox regulator APEX1; 3.1.11.2; 3.1.21.-; AP endonuclease 1; APEN; APEX nuclease; Apurinic-apyrimidinic endonuclease 1; REF-1; Redox factor-1", "protein_names_refseq": "AP endonuclease 1; AP lyase; APEX nuclease (multifunctional DNA repair enzyme) 1; DNA repair nuclease/redox regulator APEX1; DNA-(apurinic or apyrimidinic site) endonuclease; DNA-(apurinic or apyrimidinic site) lyase; apurinic-apyrimidinic endonuclease 1; apurinic/apyrimidinic endonuclease; redox factor-1", "tax_id": 9913, "disease": "", "pathway": " (bta:281630)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15607727;16617147;1708495;23673140;2441359", "class_list": "", "function": "Meiosis progression and female age affect expression profile of DNA repair APEX1 gene in bovine oocytes., [RefSeq, PubMed]; Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also incises at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in the protection from granzyme-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Also acts as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA (By similarity)., [UniProtKB, PubMed, UniProtKB]; Prediction of the 3D structure of bovine AP lyase (BAP1); models of mutants showed substitution of Arg176-->Ala leads to the loss of DNA binding whereas mutation of Asp282-->Ala and His308-->Asn leads to a decrease in the enzymatic activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0IIJ5", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006284 base-excision repair;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P23196-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23709-1", "uniprot_id": [ { "id": "NDUS3_BOVIN", "url": "https://www.uniprot.org/uniprot/P23709", "type": "external" } ], "mass": 30284.0, "length": 266, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial", "gene_name": "NDUFS3", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor", "refseq_ac": [ { "id": "NP_777244", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777244", "type": "external" } ], "gene_names_uniprotkb": "NDUFS3", "gene_names_refseq": "NDUFS3", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; 7.1.1.2; CI-30kD; Complex I-30kD; NADH-ubiquinone oxidoreductase 30 kDa subunit", "protein_names_refseq": "CI-30kD; NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial precursor; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; NADH-ubiquinone oxidoreductase 30 kDa subunit; complex I-30kD", "tax_id": 9913, "disease": "", "pathway": " (bta:287327)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10852722;12381726;18721790;1899621;1907966;25209663", "class_list": "", "function": "Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:10852722, PubMed:18721790). Essential for the catalytic activity and assembly of complex I (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Subunits of complex I and two subcomplexes (Ialpha and Ibeta) were resolved on one- and two-dimensional gels and by reverse-phase high performance liquid chromatography, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" } ], "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0072593 reactive oxygen species metabolic process;GO:0006120 mitochondrial electron transport, NADH to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P23709-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23726-1", "uniprot_id": [ { "id": "P85B_BOVIN", "url": "https://www.uniprot.org/uniprot/P23726", "type": "external" } ], "mass": 81060.0, "length": 724, "protein_name": "Phosphatidylinositol 3-kinase regulatory subunit beta", "gene_name": "PIK3R2", "organism": "Bovine", "refseq_name": "phosphatidylinositol 3-kinase regulatory subunit beta", "refseq_ac": [ { "id": "NP_777001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777001", "type": "external" } ], "gene_names_uniprotkb": "PIK3R2", "gene_names_refseq": "PIK3R2", "protein_names_uniprotkb": "Phosphatidylinositol 3-kinase regulatory subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; PtdIns-3-kinase regulatory subunit beta; PtdIns-3-kinase regulatory subunit p85-beta", "protein_names_refseq": "PI3-kinase p85 subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase regulatory subunit beta; phosphoinositide-3-kinase, regulatory subunit 2 (beta); phosphoinositide-3-kinase, regulatory subunit 2 (p85 beta); phosphoinositide-3-kinase, regulatory subunit, polypeptide 2 (p85 beta); ptdIns-3-kinase p85-beta; ptdIns-3-kinase regulatory subunit beta; ptdIns-3-kinase regulatory subunit p85-beta", "tax_id": 9913, "disease": "", "pathway": " (bta:282308); (R-BTA-109704); (R-BTA-112399); (R-BTA-114604); (R-BTA-1257604); (R-BTA-1266695); (R-BTA-1433557); (R-BTA-1660499); (R-BTA-186763); (R-BTA-198203); (R-BTA-201556); (R-BTA-202424); (R-BTA-2029485); (R-BTA-210993); (R-BTA-2424491); (R-BTA-2730905); (R-BTA-389357); (R-BTA-416476); (R-BTA-4420097); (R-BTA-512988); (R-BTA-5673001); (R-BTA-6811558); (R-BTA-8853659); (R-BTA-8980692); (R-BTA-9009391); (R-BTA-9013148); (R-BTA-9013404); (R-BTA-9013409); (R-BTA-9013420); (R-BTA-9013423); (R-BTA-9035034); (R-BTA-912526); (R-BTA-912631); (R-BTA-9696264); (R-BTA-9696270); (R-BTA-9696273); (R-BTA-9927354)", "pathway_count": 37, "publication_count": 5, "publication_id_list": "1330535;16963558;1707345;17249614;18029356", "class_list": "", "function": "Insulin receptor and phosphoinositide 3-kinase in detergent-resistant membrane rafts of rod photoreceptor outer segments, [RefSeq, PubMed]; Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy. Promotes nuclear translocation of XBP1 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results report that influenza A virus NS1 binds directly to p85beta, a regulatory subunit of phosphatidylinositol-3-kinase (PI3K), but not to the related p85alpha subunit., [RefSeq, PubMed]; These data suggest a model by which NS1 activates PI3K catalytic activity by masking a normal regulatory element specific to the p85beta inter-SH2 domain., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q17QY7", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0046935 1-phosphatidylinositol-3-kinase regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005943 phosphatidylinositol 3-kinase complex, class IA", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0010506 regulation of autophagy;GO:0015031 protein transport;GO:0032869 cellular response to insulin stimulus;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P23726-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23795-1", "uniprot_id": [ { "id": "ACES_BOVIN", "url": "https://www.uniprot.org/uniprot/P23795", "type": "external" } ], "mass": 67664.0, "length": 613, "protein_name": "Acetylcholinesterase", "gene_name": "ACHE", "organism": "Bovine", "refseq_name": "acetylcholinesterase precursor", "refseq_ac": [ { "id": "NP_001069688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069688", "type": "external" } ], "gene_names_uniprotkb": "ACHE", "gene_names_refseq": "ACHE", "protein_names_uniprotkb": "Acetylcholinesterase; 3.1.1.7; AChE", "protein_names_refseq": "acetylcholinesterase (Cartwright blood group); acetylcholinesterase T-subunit; acetylcholinesterase precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:540446)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "10867010;14690439;19038345;19292875;23352838;2365060;37761931;9693127", "class_list": "", "function": "Evaluation of GSTP1, GSTA4 and AChE Gene Methylation in Bovine Lymphocytes Cultured In Vitro with Miconazole Alone and in Combination with Mospilan 20SP. Publication Status: Online-Only, [RefSeq, PubMed]; Hydrolysis of acetylthiocoline, o-nitroacetanilide and o-nitrotrifluoroacetanilide by fetal bovine serum acetylcholinesterase, [RefSeq, PubMed]; Results strongly support the role of acetylcholinesterase in triggering amyloidogenesis and the potential therapeutic relevance of peripheral site blocker compounds., [RefSeq, PubMed]; Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft., [UniProtKB]; The monomeric form of AChE in fetal bovine serum is trimmed at the carboxyl-terminus compared to the tetrameric form, consistent with the involvement of C-terminal amino acids in the assembly of monomers into tetramers., [RefSeq, PubMed]; To date, AChE and BChE are the only proteins known that include polyproline tetramer organizing peptides in their tetrameric structure., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 1, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 744, "biomarker_type": "", "glycan_count": 42, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "O97579;Q08D79", "ec_number_list": [ { "id": "3.1.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.7", "type": "external" } ], "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0003990 acetylcholinesterase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0045202 synapse;GO:0098552 side of membrane", "go_biological_process": "GO:0019695 choline metabolic process;GO:0006581 acetylcholine catabolic process", "synthesized_glycan_count": 0, "hit_score": 5.2, "record_id": "P23795-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P23805-1", "uniprot_id": [ { "id": "CONG_BOVIN", "url": "https://www.uniprot.org/uniprot/P23805", "type": "external" } ], "mass": 37995.0, "length": 371, "protein_name": "Conglutinin", "gene_name": "CGN1", "organism": "Bovine", "refseq_name": "conglutinin precursor", "refseq_ac": [ { "id": "NP_783630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783630", "type": "external" } ], "gene_names_uniprotkb": "CGN1", "gene_names_refseq": "BC; CGN1", "protein_names_uniprotkb": "Conglutinin", "protein_names_refseq": "conglutinin 1; conglutinin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281068)", "pathway_count": 1, "publication_count": 11, "publication_id_list": "16305752;17203746;1993651;31562242;3566740;7684896;8163202;8207234;8297370;8328957;8460993", "class_list": "", "function": "Calcium-dependent lectin-like protein which binds to a yeast cell wall extract and immune complexes through the complement component (C3bi). It is capable of binding non-reducing terminal N-acetylglucosamine, mannose, and fucose residues., [UniProtKB]; Crystal structures of the immune protein conglutinin from cow reveal specific interactions of its binding site with N-acetylglucosamine, [RefSeq, PubMed]; REVIEW: The expression and characterization of conglutinin, CL-43, and CL-46 Review article, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O97748;Q58CU7;Q9TRF6", "ec_number_list": [], "go_molecular_function": "GO:0005537 D-mannose binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "P23805-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P25930-1", "uniprot_id": [ { "id": "CXCR4_BOVIN", "url": "https://www.uniprot.org/uniprot/P25930", "type": "external" } ], "mass": 39939.0, "length": 353, "protein_name": "C-X-C chemokine receptor type 4", "gene_name": "CXCR4", "organism": "Bovine", "refseq_name": "C-X-C chemokine receptor type 4", "refseq_ac": [ { "id": "NP_776726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776726", "type": "external" } ], "gene_names_uniprotkb": "CXCR4", "gene_names_refseq": "CXCR4", "protein_names_uniprotkb": "C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; Fusin; LCR1; LESTR; Leukocyte-derived seven transmembrane domain receptor; SDF-1 receptor; Stromal cell-derived factor 1 receptor", "protein_names_refseq": "C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; LCR1; LESTR; SDF-1 receptor; chemokine (C-X-C motif) receptor 4; fusin; leukocyte-derived seven transmembrane domain receptor; stromal cell-derived factor 1 receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281736)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "1661837;24059096;24784705;27117936;32353075;34763920;8234909", "class_list": "", "function": "Cellular detection of the chemokine receptor CXCR4 in bovine mammary glands and its distribution and regulation on bovine leukocytes., [RefSeq, PubMed]; Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. CXCR4 is coupled to G(i) G alpha proteins and mediates inhibition of adenylate cyclase. Involved in the AKT signaling cascade. Plays a role in regulation of cell migration, e.g. during wound healing. Also acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). Involved in hematopoiesis and in cardiac ventricular septum formation. Also plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. Involved in cerebellar development; in the CNS, could mediate hippocampal-neuron surviva (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Study identified stromal cell-derived factor 1 (SDF1), which was expressed in bovine cumulus-oocyte complexes (COCs), and its receptor CXCR4 in sperm, as a sperm chemoattractants and proposed that SDF1 is a chemotactic factor for bovine sperm to regulate their migration towards an oocyte via the CXCR4 receptor. Publication Status: Online-Only, [RefSeq, PubMed]; The combination of low expression of CXCR4 and high expression of IL-10 might be closely concerned with some bias for the production of PI calves., [RefSeq, PubMed]; The current analysis failed in identifying a causal mutation on the CXCR4 gene underlying a previously reported quantitative trait loci for cattle trypanotolerance on bovine chromosome 2., [RefSeq, PubMed]; There is a potential link between follicular SDF1/CXCR4 activation and the regulation of ovulation-related genes in cows and horses., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q3MHJ3", "ec_number_list": [], "go_molecular_function": "GO:0016493 C-C chemokine receptor activity;GO:0019957 C-C chemokine binding;GO:0038147 C-X-C motif chemokine 12 receptor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0009897 external side of plasma membrane;GO:0005770 late endosome", "go_biological_process": "GO:0006955 immune response;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0019722 calcium-mediated signaling;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P25930-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P26779-1", "uniprot_id": [ { "id": "SAP_BOVIN", "url": "https://www.uniprot.org/uniprot/P26779", "type": "external" } ], "mass": 58051.0, "length": 525, "protein_name": "Prosaposin", "gene_name": "PSAP", "organism": "Bovine", "refseq_name": "prosaposin precursor", "refseq_ac": [ { "id": "NP_776586", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776586", "type": "external" } ], "gene_names_uniprotkb": "PSAP", "gene_names_refseq": "PSAP", "protein_names_uniprotkb": "Prosaposin; A1 activator; CSAct; Cerebroside sulfate activator; Co-beta-glucosidase; Component C; Dispersin; Glucosylceramidase activator; Proactivator polypeptide; Protein A; Protein C; SAP-1; SAP-2; Sphingolipid activator protein 1; Sphingolipid activator protein 2; Sulfatide/GM1 activator", "protein_names_refseq": "proactivator polypeptide; prosaposin (variant Gaucher disease and variant metachromatic leukodystrophy); prosaposin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281433)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1554743", "class_list": "", "function": "Acts as a lysosomal activator protein that stimulates acid ceramidase (EC 3.5.1.23) by solubilizing and presenting ceramide substrates at the lipid-water interface, facilitating their hydrolysis into sphingosine and fatty acids. It also activates acid sphingomyelinase (EC 3.1.4.12), though ceramide catabolism represents its primary physiological role., [UniProtKB, UniProtKB]; Acts as an essential lysosomal cofactor that activates acid beta-glucosylceramidases (EC 3.2.1.45) by altering lipid bilayer properties to facilitate enzyme access to its membrane-embedded glucosylceramide substrate, while also protecting glucocerebrosidase from intralysosomal proteolytic degradation., [UniProtKB, UniProtKB]; Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling., [UniProtKB, UniProtKB, UniProtKB]; Saposins are specific low-molecular mass non-enzymatic glycoproteins that act as activator proteins for lysosomal sphingolipid-degrading enzymes, facilitating the hydrolysis of sphingolipids by extracting lipid substrates from membranes and presenting them to their respective enzymes. They are derived from a common precursor protein, prosaposin, which is proteolytically cleaved to yield four homologous proteins (saposin A, B, C, and D), each with distinct but partially overlapping lipid and enzyme specificities., [UniProtKB, UniProtKB]; Stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A ARSA (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases., [UniProtKB, UniProtKB]; With saposin-A, stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase GALC (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate., [UniProtKB, UniProtKB]; With saposin-C, stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase GALC (EC 3.2.1.46)., [UniProtKB, UniProtKB]; acts as an essential lysosomal cofactor that activates galactocerebrosidase (GALC, EC 3.2.1.46) by facilitating enzyme access to its membrane-embedded galactosylceramide substrate, the principal lipid component of myelin., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q2HJG9;Q9N2G4", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0008289 lipid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0016020 membrane;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0006665 sphingolipid metabolic process;GO:0019216 regulation of lipid metabolic process;GO:0060736 prostate gland growth;GO:0060742 epithelial cell differentiation involved in prostate gland development", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P26779-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27214-1", "uniprot_id": [ { "id": "ANX11_BOVIN", "url": "https://www.uniprot.org/uniprot/P27214", "type": "external" } ], "mass": 54018.0, "length": 503, "protein_name": "Annexin A11", "gene_name": "ANXA11", "organism": "Bovine", "refseq_name": "annexin A11 isoform 2", "refseq_ac": [ { "id": "NP_776927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776927", "type": "external" } ], "gene_names_uniprotkb": "ANXA11; ANX11", "gene_names_refseq": "ANXA11", "protein_names_uniprotkb": "Annexin A11; Annexin XI; Annexin-11; CAP-50; Calcyclin-associated annexin-50", "protein_names_refseq": "CAP-50; annexin A11 isoform 2; annexin XI; annexin-11; calcyclin-associated annexin-50", "tax_id": 9913, "disease": "", "pathway": " (bta:282142)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1372001;1535225;1618851;9497364", "class_list": "", "function": "Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P27215;Q0VD55", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0044548 S100 protein binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0006909 phagocytosis;GO:0032506 cytokinetic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P27214-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27479-1", "uniprot_id": [ { "id": "LOX15_BOVIN", "url": "https://www.uniprot.org/uniprot/P27479", "type": "external" } ], "mass": 75124.0, "length": 663, "protein_name": "Polyunsaturated fatty acid lipoxygenase ALOX15", "gene_name": "ALOX15", "organism": "Bovine", "refseq_name": "polyunsaturated fatty acid lipoxygenase ALOX15", "refseq_ac": [ { "id": "NP_776926", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776926", "type": "external" } ], "gene_names_uniprotkb": "ALOX15", "gene_names_refseq": "15-LOX; ALOX12; ALOX15", "protein_names_uniprotkb": "Polyunsaturated fatty acid lipoxygenase ALOX15; 1.13.11.-; 1.13.11.12; 1.13.11.31; 1.13.11.33; 12-LOX; 12/15-lipoxygenase; 15-LOX; Arachidonate 12-lipoxygenase, leukocyte-type; Arachidonate 15-lipoxygenase; Arachidonate omega-6 lipoxygenase; Erythroid cell-specific 15-lipoxygenase; Hepoxilin A3 synthase Alox15; Linoleate 13S-lipoxygenase", "protein_names_refseq": "12-LOX; 12/15-lipoxygenase; 12S-LOX; 12S-lipoxygenase; arachidonate 12-lipoxygenase, 12S-type; arachidonate 12-lipoxygenase, leukocyte-type; arachidonate omega-6 lipoxygenase; erythroid cell-specific 15-lipoxygenase; hepoxilin A3 synthase Alox15; linoleate 13S-lipoxygenase; polyunsaturated fatty acid lipoxygenase ALOX15", "tax_id": 9913, "disease": "", "pathway": " (bta:282139); (R-BTA-2142691); (R-BTA-2142712); (R-BTA-2142770); (R-BTA-9018677); (R-BTA-9018681); (R-BTA-9018896); (R-BTA-9023661); (R-BTA-9025106); (R-BTA-9026286)", "pathway_count": 10, "publication_count": 2, "publication_id_list": "1539676;19393038", "class_list": "", "function": "Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:1539676). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (By similarity). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response. In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties. Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells. It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function. It may also exert a negative effect on skeletal development by regulating bone mass through this pathway. As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (By similarity). Finally, it is also involved in the cellular response to IL13/interleukin-13 (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MCH9", "ec_number_list": [ { "id": "1.13.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.31", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "1.13.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.33", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:0016165 linoleate 13S-lipoxygenase activity;GO:0050473 arachidonate 15-lipoxygenase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0034440 lipid oxidation;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0043651 linoleic acid metabolic process;GO:0071277 cellular response to calcium ion;GO:0019395 fatty acid oxidation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P27479-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27595-1", "uniprot_id": [ { "id": "HXK1_BOVIN", "url": "https://www.uniprot.org/uniprot/P27595", "type": "external" } ], "mass": 103064.0, "length": 918, "protein_name": "Hexokinase-1", "gene_name": "HK1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HK1", "gene_names_refseq": "", "protein_names_uniprotkb": "Hexokinase-1; 2.7.1.1; Brain form hexokinase; HK I; Hexokinase type I", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1783373;2719857", "class_list": "", "function": "Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.-", "type": "external" } ], "go_molecular_function": "GO:0004340 glucokinase activity;GO:0008865 fructokinase activity;GO:0019158 mannokinase activity;GO:0005524 ATP binding;GO:0005536 D-glucose binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0006006 glucose metabolic process;GO:0001678 intracellular glucose homeostasis;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P27595-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P27922-1", "uniprot_id": [ { "id": "SC6A3_BOVIN", "url": "https://www.uniprot.org/uniprot/P27922", "type": "external" } ], "mass": 75691.0, "length": 693, "protein_name": "Sodium-dependent dopamine transporter", "gene_name": "SLC6A3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC6A3", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium-dependent dopamine transporter; DA transporter; DAT; Solute carrier family 6 member 3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1722321", "class_list": "", "function": "Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1722321). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0005330 dopamine:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043005 neuron projection", "go_biological_process": "GO:1990384 hyaloid vascular plexus regression;GO:0006865 amino acid transport;GO:0015872 dopamine transport;GO:0035725 sodium ion transmembrane transport;GO:0006836 neurotransmitter transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P27922-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28053-1", "uniprot_id": [ { "id": "MMP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P28053", "type": "external" } ], "mass": 53354.0, "length": 469, "protein_name": "Interstitial collagenase", "gene_name": "MMP1", "organism": "Bovine", "refseq_name": "interstitial collagenase precursor", "refseq_ac": [ { "id": "NP_776537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776537", "type": "external" } ], "gene_names_uniprotkb": "MMP1; CLG", "gene_names_refseq": "MMP-1; MMP1", "protein_names_uniprotkb": "Interstitial collagenase; 3.4.24.7; Fibroblast collagenase; MMP-1; Matrix metalloproteinase-1", "protein_names_refseq": "fibroblast collagenase; interstitial collagenase precursor; interstitial collagenase; matrix metallopeptidase 1 (interstitial collagenase); matrix metalloproteinase-1", "tax_id": 9913, "disease": "", "pathway": " (bta:281308)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12080004;1311165;23415423;25496672;25924700;26985938;27281703;7894061", "class_list": "", "function": "BoHV-4 infection affects various pathways related to cell proliferation and cell surface integrity, at least three of which were centered on upregulation of matrix metalloproteinase 1 (MMP1). MMP1 transcription was upregulated by the BoHV-4 transactivator IE2/RTA, leading to abnormally high metalloproteinase tissue levels, potentially leading to defective endometrium healing and unresolved inflammation., [RefSeq, PubMed]; Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X., [UniProtKB]; Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates., [RefSeq, PubMed]; Data suggest that luteolytic factors (such as interferon gamma, tumor necrosis factor alpha, and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells., [RefSeq, PubMed]; The differential expression and localization of membrane-type 1 matrix metalloproteinase in the corpus luteum suggest that it may have multiple functions throughout the course of the estrous cycle,including activation of pro-MMP-2, [RefSeq, PubMed]; The expression patterns of MMP1, MMP2, and MMP8 were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1, MMP2, and MMP8 expression levels with meat quality traits were analyzed in cattle. The expression of MMP1, MMP2, and MMP8 were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues. Publication Status: Online-Only, [RefSeq, PubMed]; The results showed that a decrease in MMP-1 and MMP-2 gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process;GO:0071492 cellular response to UV-A", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P28053-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28783-1", "uniprot_id": [ { "id": "S10A9_BOVIN", "url": "https://www.uniprot.org/uniprot/P28783", "type": "external" } ], "mass": 17114.0, "length": 156, "protein_name": "Protein S100-A9", "gene_name": "S100A9", "organism": "Bovine", "refseq_name": "protein S100-A9", "refseq_ac": [ { "id": "NP_001039793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039793", "type": "external" } ], "gene_names_uniprotkb": "S100A9", "gene_names_refseq": "S100A9", "protein_names_uniprotkb": "Protein S100-A9; BEE22; Calgranulin-B; Neutrophil cytosolic 23 kDa protein; S100 calcium-binding protein A9; p23", "protein_names_refseq": "BEE22; calgranulin-B; neutrophil cytosolic 23 kDa protein; p23; protein S100-A9", "tax_id": 9913, "disease": "", "pathway": " (bta:532569)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1610833;23533291;29774569;31945120;8505358", "class_list": "", "function": "Data suggest that up-regulation of S100A8 and S100A9 is a key component of early endometrial response to uterine involution in the post-partum period and to prevent chronic endometritis/uterine inflammation; up-regulation can be influenced by diet. Publication Status: Online-Only, [RefSeq, PubMed]; S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Also participates in regulatory T-cell differentiation together with CD69. Activates NADPH-oxidase by facilitating the enzyme complex assembly at the cell membrane, transferring arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2/P67PHOX. The extracellular functions involve pro-inflammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its pro-inflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF-kappa-B signaling pathways resulting in the amplification of the pro-inflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2+) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect; regulates cell survival via ITGAM/ITGB and TLR4 and a signaling mechanism involving MEK-ERK. Its role as an oxidant scavenger has a protective role in preventing exaggerated tissue damage by scavenging oxidants. The iNOS-S100A8/A9 transnitrosylase complex is proposed to direct selective inflammatory stimulus-dependent S-nitrosylation of multiple targets such as GAPDH, NXA5, EZR, MSN and VIM by recognizing a [IL]-x-C-x-x-[DE] motif., [UniProtKB, UniProtKB]; Study of nonsynonymous DNA variation in the functional domain of the S100A7, -A8, -A9 genes in taurine cattle and yak, [RefSeq, PubMed]; These results indicate that direct exposure to S100A9 exerted adverse effects on sperm function and embryo development. These findings suggest that excessive dose of S100A9 may have an adverse effect to the reproductive machinery by inducing inflammation and tissue dysfunction. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2NKV0", "ec_number_list": [], "go_molecular_function": "GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding;GO:0016209 antioxidant activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0045087 innate immune response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006915 apoptotic process;GO:0002523 leukocyte migration involved in inflammatory response;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P28783-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P28800-1", "uniprot_id": [ { "id": "A2AP_BOVIN", "url": "https://www.uniprot.org/uniprot/P28800", "type": "external" } ], "mass": 54711.0, "length": 492, "protein_name": "Alpha-2-antiplasmin", "gene_name": "SERPINF2", "organism": "Bovine", "refseq_name": "alpha-2-antiplasmin precursor", "refseq_ac": [ { "id": "NP_777095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777095", "type": "external" } ], "gene_names_uniprotkb": "SERPINF2; PLI", "gene_names_refseq": "PLI; SERPINF2", "protein_names_uniprotkb": "Alpha-2-antiplasmin; Alpha-2-AP; Alpha-2-PI; Alpha-2-plasmin inhibitor; Serpin F2", "protein_names_refseq": "alpha-2-AP; alpha-2-PI; alpha-2-antiplasmin precursor; alpha-2-antiplasmin; alpha-2-plasmin inhibitor; serine (or cysteine) proteinase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2; serpin F2", "tax_id": 9913, "disease": "", "pathway": " (bta:282522); (R-BTA-114608); (R-BTA-75205)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "1385210;7513654", "class_list": "", "function": "Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006953 acute-phase response;GO:0051918 negative regulation of fibrinolysis;GO:0050820 positive regulation of coagulation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P28800-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P29702-1", "uniprot_id": [ { "id": "FNTA_BOVIN", "url": "https://www.uniprot.org/uniprot/P29702", "type": "external" } ], "mass": 43845.0, "length": 375, "protein_name": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "gene_name": "FNTA", "organism": "Bovine", "refseq_name": "protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha", "refseq_ac": [ { "id": "NP_803464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803464", "type": "external" } ], "gene_names_uniprotkb": "FNTA", "gene_names_refseq": "FNTA", "protein_names_uniprotkb": "Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; 2.5.1.58; 2.5.1.59; CAAX farnesyltransferase subunit alpha; FTase-alpha; GGTase-I-alpha; Ras proteins prenyltransferase subunit alpha; Type I protein geranyl-geranyltransferase subunit alpha", "protein_names_refseq": "CAAX farnesyltransferase subunit alpha; FTase-alpha; GGTase-I-alpha; protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase subunit alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:281169)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1918005", "class_list": "", "function": "Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2KIF0", "ec_number_list": [ { "id": "2.5.1.58", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.58", "type": "external" }, { "id": "2.5.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.59", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0004660 protein farnesyltransferase activity;GO:0004661 protein geranylgeranyltransferase activity;GO:0004662 CAAX-protein geranylgeranyltransferase activity", "go_cellular_component": "GO:0005953 CAAX-protein geranylgeranyltransferase complex;GO:0005965 protein farnesyltransferase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0018343 protein farnesylation;GO:0018344 protein geranylgeranylation;GO:0007323 peptide pheromone maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P29702-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30122-1", "uniprot_id": [ { "id": "CEL_BOVIN", "url": "https://www.uniprot.org/uniprot/P30122", "type": "external" } ], "mass": 65162.0, "length": 597, "protein_name": "Bile salt-activated lipase", "gene_name": "CEL", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CEL", "gene_names_refseq": "", "protein_names_uniprotkb": "Bile salt-activated lipase; 3.1.1.13; 3.1.1.3; 3.1.1.6; BAL; BSSL; Bile salt-stimulated lipase; Carboxyl ester lipase; Cholesterol esterase; Pancreatic lysophospholipase; Sterol esterase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "10220579;2590203;9331420;9548741", "class_list": "", "function": "Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA) (PubMed:10220579). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.71", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0004771 sterol ester esterase activity;GO:0004806 triacylglycerol lipase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0008126 acetylesterase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0046514 ceramide catabolic process;GO:0030157 pancreatic juice secretion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P30122-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30546-1", "uniprot_id": [ { "id": "HRH1_BOVIN", "url": "https://www.uniprot.org/uniprot/P30546", "type": "external" } ], "mass": 55957.0, "length": 491, "protein_name": "Histamine H1 receptor", "gene_name": "HRH1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HRH1", "gene_names_refseq": "", "protein_names_uniprotkb": "Histamine H1 receptor; H1R; HH1R", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1722337", "class_list": "", "function": "G protein-coupled receptor for histamine, a biogenic amine that functions as an immune modulator and a neurotransmitter (PubMed:1722337). Through the H1 receptor, histamine mediates the contraction of smooth muscles and increases capillary permeability due to contraction of terminal venules. Also mediates neurotransmission in the central nervous system and thereby regulates circadian rhythms, emotional and locomotor activities as well as cognitive functions (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004969 histamine receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0045202 synapse", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0007268 chemical synaptic transmission;GO:0045907 positive regulation of vasoconstriction;GO:0043114 regulation of vascular permeability", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P30546-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P30922-1", "uniprot_id": [ { "id": "CH3L1_BOVIN", "url": "https://www.uniprot.org/uniprot/P30922", "type": "external" } ], "mass": 43032.0, "length": 383, "protein_name": "Chitinase-3-like protein 1", "gene_name": "CHI3L1", "organism": "Bovine", "refseq_name": "chitinase-3-like protein 1 precursor", "refseq_ac": [ { "id": "NP_001073688", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073688", "type": "external" } ], "gene_names_uniprotkb": "CHI3L1", "gene_names_refseq": "CGP-39; CHI3L1; CLP-1; GP-39; SPC-40; SPS-40; YKL-40", "protein_names_uniprotkb": "Chitinase-3-like protein 1; 39 kDa whey protein; CGP-39; CLP-1; Cartilage glycoprotein 39; Chitinase-like protein 1; GP-39; SPC-40; Signal-processing protein", "protein_names_refseq": "39 kDa whey protein; 40 kDa secretory signalling glycoprotein; cartilage glycoprotein-39; chitinase-3-like protein 1 precursor; chitinase-3-like protein 1; chitinase-like protein 1; signal processing protein", "tax_id": 9913, "disease": "", "pathway": " (bta:286869)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "16305752;16704970;16929095;19307719;3122754", "class_list": "", "function": "Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung (By similarity)., [UniProtKB, PubMed]; Chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation, [RefSeq, PubMed]; Two 2-methylpentane-2,4-diol molecules are bound at subsites -2 and -1, inducing a rare obstructive conformation of Trp78 and twisting of the side chains of Glu269 and Ile272., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O18949;Q58CW2;Q7YSE8", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0008061 chitin binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006954 inflammatory response;GO:0034612 response to tumor necrosis factor;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0005975 carbohydrate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P30922-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31039-1", "uniprot_id": [ { "id": "SDHA_BOVIN", "url": "https://www.uniprot.org/uniprot/P31039", "type": "external" } ], "mass": 72944.0, "length": 665, "protein_name": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "gene_name": "SDHA", "organism": "Bovine", "refseq_name": "succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776603", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776603", "type": "external" } ], "gene_names_uniprotkb": "SDHA; SDH2; SDHFP1", "gene_names_refseq": "SDHA", "protein_names_uniprotkb": "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; 1.1.5.-; 1.3.5.1; Flavoprotein subunit of complex II; Fp; Malate dehydrogenase [quinone] flavoprotein subunit", "protein_names_refseq": "flavoprotein subunit of complex II; fp; malate dehydrogenase [quinone] flavoprotein subunit; mitochondrial succinate dehydrogenase complex subunit A; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; succinate dehydrogenase complex subunit A; succinate dehydrogenase complex, subunit A, flavoprotein (Fp); succinate dehydrogenase flavoprotein subunit A", "tax_id": 9913, "disease": "", "pathway": " (bta:281480)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10612251;1375942;1864383;28100784;2902878;8142412;8417779", "class_list": "", "function": "Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (PubMed:2902878, PubMed:8417779). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate (PubMed:1864383, PubMed:2902878). Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (PubMed:2902878). Can act as a tumor suppressor (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9TUY8", "ec_number_list": [ { "id": "1.3.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.5.1", "type": "external" }, { "id": "1.1.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.-", "type": "external" } ], "go_molecular_function": "GO:0009055 electron transfer activity;GO:0050660 flavin adenine dinucleotide binding;GO:0008177 succinate dehydrogenase (quinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045273 respiratory chain complex II (succinate dehydrogenase)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006121 mitochondrial electron transport, succinate to ubiquinone", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P31039-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31408-1", "uniprot_id": [ { "id": "VATB2_BOVIN", "url": "https://www.uniprot.org/uniprot/P31408", "type": "external" } ], "mass": 56577.0, "length": 511, "protein_name": "V-type proton ATPase subunit B, brain isoform", "gene_name": "ATP6V1B2", "organism": "Bovine", "refseq_name": "V-type proton ATPase subunit B, brain isoform isoform 1", "refseq_ac": [ { "id": "NP_001001146", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001146", "type": "external" } ], "gene_names_uniprotkb": "ATP6V1B2; ATP6B2", "gene_names_refseq": "ATP6V1B2", "protein_names_uniprotkb": "V-type proton ATPase subunit B, brain isoform; Endomembrane proton pump 58 kDa subunit; V-ATPase subunit B 2; Vacuolar proton pump subunit B 2", "protein_names_refseq": "ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2; H+-ATPase B subunit; H+-ATPase non-catalytic subunit B; V-ATPase subunit B 2; V-type proton ATPase subunit B, brain isoform isoform 1; endomembrane proton pump 58 kDa subunit; vacuolar H+-ATPase; vacuolar proton pump subunit B 2", "tax_id": 9913, "disease": "", "pathway": " (bta:338082); (R-BTA-1222556); (R-BTA-77387); (R-BTA-917977); (R-BTA-9639288); (R-BTA-983712)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "1371275;1373501;1835703;32764564", "class_list": "", "function": "Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32764564). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32764564). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). In renal intercalated cells, can partially compensate the lack of ATP6V1B1 and mediate secretion of protons (H+) into the urine under base-line conditions but not in conditions of acid load (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FUX5;Q28058", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0046961 proton-transporting ATPase activity, rotational mechanism", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0042470 melanosome;GO:0030665 clathrin-coated vesicle membrane", "go_biological_process": "GO:0046034 ATP metabolic process;GO:0045851 pH reduction;GO:0007035 vacuolar acidification;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P31408-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P31836-1", "uniprot_id": [ { "id": "NCAM1_BOVIN", "url": "https://www.uniprot.org/uniprot/P31836", "type": "external" } ], "mass": 93894.0, "length": 853, "protein_name": "Neural cell adhesion molecule 1", "gene_name": "NCAM1", "organism": "Bovine", "refseq_name": "neural cell adhesion molecule 1 precursor", "refseq_ac": [ { "id": "NP_776824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776824", "type": "external" } ], "gene_names_uniprotkb": "NCAM1; NCAM", "gene_names_refseq": "NCAM1", "protein_names_uniprotkb": "Neural cell adhesion molecule 1; N-CAM-1; NCAM-1", "protein_names_refseq": "N-CAM-1; NCAM-1; cell adhesion molecule, neural; neural cell adhesion molecule 1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281941)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1765159;2776887;3512556", "class_list": "", "function": "This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc., [UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon", "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0001837 epithelial to mesenchymal transition;GO:0007411 axon guidance;GO:0070593 dendrite self-avoidance", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P31836-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P32120-1", "uniprot_id": [ { "id": "ARRB2_BOVIN", "url": "https://www.uniprot.org/uniprot/P32120", "type": "external" } ], "mass": 47224.0, "length": 420, "protein_name": "Beta-arrestin-2", "gene_name": "ARRB2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ARRB2", "gene_names_refseq": "", "protein_names_uniprotkb": "Beta-arrestin-2; Arrestin beta-2; Arrestin-3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 15, "publication_id_list": "10022830;10085139;10521508;12850288;16439357;18435604;18703513;18802075;19332542;37209686;38175886;7822302;8340388;9169476;9767391", "class_list": "", "function": "Functions in regulating agonist-mediated G protein-coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes (PubMed:37209686, PubMed:38175886). During homologous desensitization, beta-arrestins bind to the GPCR-phosphorylated receptor and sterically preclude its coupling to the cognate G protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as a signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as a signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in both localization to primary cilium and endocytosis of smoothened (SMO) in a GRK2-dependent process. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3 (By similarity). Acts as an adapter protein coupling FFAR4 receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis. During the activation step of NLRP3 inflammasome, directly associates with NLRP3 leading to inhibition of pro-inflammatory cytokine release and inhibition of inflammation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 9, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O77565;O77566", "ec_number_list": [], "go_molecular_function": "GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0001664 G protein-coupled receptor binding;GO:0035091 phosphatidylinositol binding;GO:0031701 angiotensin receptor binding;GO:0031748 D1 dopamine receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0007165 signal transduction;GO:0015031 protein transport;GO:0031623 receptor internalization;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0019233 sensory perception of pain", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P32120-1", "record_type": "protein", "filter_code": "0000000.0100100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33097-1", "uniprot_id": [ { "id": "AATC_BOVIN", "url": "https://www.uniprot.org/uniprot/P33097", "type": "external" } ], "mass": 46399.0, "length": 413, "protein_name": "Aspartate aminotransferase, cytoplasmic", "gene_name": "GOT1", "organism": "Bovine", "refseq_name": "aspartate aminotransferase, cytoplasmic", "refseq_ac": [ { "id": "NP_803468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803468", "type": "external" } ], "gene_names_uniprotkb": "GOT1", "gene_names_refseq": "GOT1; cAspAT; cCAT", "protein_names_uniprotkb": "Aspartate aminotransferase, cytoplasmic; 2.6.1.1; 2.6.1.3; Cysteine aminotransferase, cytoplasmic; Cysteine transaminase, cytoplasmic; Glutamate oxaloacetate transaminase 1; Transaminase A; cAspAT; cCAT", "protein_names_refseq": "aspartate aminotransferase 1; aspartate aminotransferase, cytoplasmic; cysteine aminotransferase, cytoplasmic; cysteine transaminase, cytoplasmic; glutamate oxaloacetate transaminase 1, soluble; transaminase A", "tax_id": 9913, "disease": "", "pathway": " (bta:281206); (R-BTA-8963693); (R-BTA-9856872)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "16305752;8224363", "class_list": "", "function": "Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2KJF2;Q5E9R4", "ec_number_list": [ { "id": "2.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.1", "type": "external" }, { "id": "2.6.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.3", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004069 L-aspartate:2-oxoglutarate aminotransferase activity;GO:0004609 phosphatidylserine decarboxylase activity;GO:0047801 L-cysteine transaminase activity;GO:0120554 2-aminobutanoate transaminase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006533 L-aspartate catabolic process;GO:0032869 cellular response to insulin stimulus;GO:0051384 response to glucocorticoid;GO:0006094 gluconeogenesis;GO:0006114 glycerol biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P33097-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P33433-1", "uniprot_id": [ { "id": "HRG_BOVIN", "url": "https://www.uniprot.org/uniprot/P33433", "type": "external" } ], "mass": 44471.0, "length": 396, "protein_name": "Histidine-rich glycoprotein", "gene_name": "HRG", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HRG", "gene_names_refseq": "", "protein_names_uniprotkb": "Histidine-rich glycoprotein; HPRG; Histidine-proline-rich glycoprotein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8348977", "class_list": "", "function": "Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Inhibits rosette formation. Acts as an adapter protein and implicated in regulating many processes such as immune complex and pathogen clearance, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0008270 zinc ion binding;GO:0043395 heparan sulfate proteoglycan binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:2000504 positive regulation of blood vessel remodeling;GO:0010543 regulation of platelet activation;GO:0007162 negative regulation of cell adhesion;GO:0008285 negative regulation of cell population proliferation;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P33433-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.1000000000001.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35071-1", "uniprot_id": [ { "id": "CFTR_BOVIN", "url": "https://www.uniprot.org/uniprot/P35071", "type": "external" } ], "mass": 167758.0, "length": 1481, "protein_name": "Cystic fibrosis transmembrane conductance regulator", "gene_name": "CFTR", "organism": "Bovine", "refseq_name": "cystic fibrosis transmembrane conductance regulator", "refseq_ac": [ { "id": "NP_776443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776443", "type": "external" } ], "gene_names_uniprotkb": "CFTR; ABCC7", "gene_names_refseq": "CFTR", "protein_names_uniprotkb": "Cystic fibrosis transmembrane conductance regulator; 5.6.1.6; ATP-binding cassette sub-family C member 7; CFTR; Channel conductance-controlling ATPase; cAMP-dependent chloride channel", "protein_names_refseq": "ATP-binding cassette sub-family C member 7; ATP-binding cassette transporter sub-family C member 7; cAMP-dependent chloride channel; channel conductance-controlling ATPase; cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7); cystic fibrosis transmembrane conductance regulator", "tax_id": 9913, "disease": "", "pathway": " (bta:281067)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12782133;12917688;1719001;31269333", "class_list": "", "function": "Conserved CFTR sequences between species are examined for potential regulatory elements. Regions of introns 2, 3, 10, 17a, 18, and 21 and 3' flanking sequence corresponding to human CFTR DNase I hypersensitive sites showed high homology in cow and pig., [RefSeq, PubMed]; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Possesses an intrinsic ATPase activity and utilizes ATP to gate its channel; the passive flow of anions through the channel is gated by cycles of ATP binding and hydrolysis by the ATP-binding domains (By similarity). The ion channel is also permeable to HCO(3)(-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. Modulates the activity of the epithelial sodium channel (ENaC) complex, in part by regulating the cell surface expression of the ENaC complex. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the transporter SLC4A7. Can inhibit the chloride channel activity of ANO1 (By similarity). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The missense mutation Met468Leu within CFTR gene is associated with antioxidant enzyme activity and mitochondrial function of bovine thawed sperm without affecting their motility., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A4D7S2", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005260 intracellularly ATP-gated chloride channel activity;GO:0019869 chloride channel inhibitor activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0071320 cellular response to cAMP;GO:1904322 cellular response to forskolin;GO:0048240 sperm capacitation;GO:1902476 chloride transmembrane transport;GO:0060081 membrane hyperpolarization", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P35071-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P35526-1", "uniprot_id": [ { "id": "CLIC5_BOVIN", "url": "https://www.uniprot.org/uniprot/P35526", "type": "external" } ], "mass": 48959.0, "length": 437, "protein_name": "Chloride intracellular channel protein 5", "gene_name": "CLIC5", "organism": "Bovine", "refseq_name": "chloride intracellular channel protein 5", "refseq_ac": [ { "id": "NP_776701", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776701", "type": "external" } ], "gene_names_uniprotkb": "CLIC5", "gene_names_refseq": "CLIC5", "protein_names_uniprotkb": "Chloride intracellular channel protein 5; 1.8.-.-; Chlorine channel protein p64; Glutaredoxin-like oxidoreductase CLIC5", "protein_names_refseq": "chloride channel protein p64; chloride intracellular channel protein 5; chlorine channel protein p64; glutaredoxin-like oxidoreductase CLIC5", "tax_id": 9913, "disease": "", "pathway": " (bta:281696)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "10191309;20335315;7686908", "class_list": "", "function": "CLIC5A colocalizes with ezrin and podocalyxin in podocytes and is required for the development/maintenance of the proper glomerular endothelial cell and podocyte architecture., [RefSeq, PubMed]; In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form non-selective ion channels almost equally permeable to Na(+), K(+) and Cl(-) (By similarity). Required for normal hearing (By similarity). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (By similarity). Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0005254 chloride channel activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007601 visual perception;GO:0007605 sensory perception of sound;GO:0006821 chloride transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P35526-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P36225-1", "uniprot_id": [ { "id": "MAP4_BOVIN", "url": "https://www.uniprot.org/uniprot/P36225", "type": "external" } ], "mass": 111915.0, "length": 1072, "protein_name": "Microtubule-associated protein 4", "gene_name": "MAP4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MAP4", "gene_names_refseq": "", "protein_names_uniprotkb": "Microtubule-associated protein 4; MAP-4; MAP-U; Microtubule-associated protein U", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "12773533;15840943;1892837;2033072;2380192", "class_list": "", "function": "Non-neuronal microtubule-associated protein. Promotes microtubule assembly., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 28, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7BKA6;Q867A8;Q8MJX2;Q8MJX3", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005815 microtubule organizing center;GO:0043005 neuron projection", "go_biological_process": "GO:0031175 neuron projection development;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P36225-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38572-1", "uniprot_id": [ { "id": "UPK1A_BOVIN", "url": "https://www.uniprot.org/uniprot/P38572", "type": "external" } ], "mass": 28902.0, "length": 258, "protein_name": "Uroplakin-1a", "gene_name": "UPK1A", "organism": "Bovine", "refseq_name": "uroplakin-1a", "refseq_ac": [ { "id": "NP_788784", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788784", "type": "external" } ], "gene_names_uniprotkb": "UPK1A", "gene_names_refseq": "UPK1A", "protein_names_uniprotkb": "Uroplakin-1a; UP1a; UPIa; Uroplakin Ia", "protein_names_refseq": "UP1a; UPIa; uroplakin IA; uroplakin-1a", "tax_id": 9913, "disease": "", "pathway": " (bta:282112)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "12475947;24914955;8138569", "class_list": "", "function": "Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions., [UniProtKB]; These data support a model in which SNX31 mediates the endocytic degradation of uroplakins. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0120001 apical plasma membrane urothelial plaque;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032991 protein-containing complex", "go_biological_process": "GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P38572-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P38657-1", "uniprot_id": [ { "id": "PDIA3_BOVIN", "url": "https://www.uniprot.org/uniprot/P38657", "type": "external" } ], "mass": 56930.0, "length": 505, "protein_name": "Protein disulfide-isomerase A3", "gene_name": "PDIA3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PDIA3; GRP58", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein disulfide-isomerase A3; 5.3.4.1; 58 kDa glucose-regulated protein; 58 kDa microsomal protein; Disulfide isomerase ER-60; ER protein 57; ER protein 60; ERp57; ERp60; Endoplasmic reticulum resident protein 57; Endoplasmic reticulum resident protein 60; p58", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8529662", "class_list": "", "function": "Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0009986 cell surface;GO:0042470 melanosome", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0002250 adaptive immune response;GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P38657-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40293-1", "uniprot_id": [ { "id": "CD79A_BOVIN", "url": "https://www.uniprot.org/uniprot/P40293", "type": "external" } ], "mass": 24630.0, "length": 223, "protein_name": "B-cell antigen receptor complex-associated protein alpha chain", "gene_name": "CD79A", "organism": "Bovine", "refseq_name": "B-cell antigen receptor complex-associated protein alpha chain precursor", "refseq_ac": [ { "id": "NP_776691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776691", "type": "external" } ], "gene_names_uniprotkb": "CD79A; IGA; MB-1", "gene_names_refseq": "CD79A; MB-1", "protein_names_uniprotkb": "B-cell antigen receptor complex-associated protein alpha chain; Ig-alpha; MB-1 membrane glycoprotein; Membrane-bound immunoglobulin-associated protein; Surface IgM-associated protein", "protein_names_refseq": "B-cell antigen receptor complex-associated protein alpha chain precursor; B-cell antigen receptor complex-associated protein alpha chain; CD79A antigen (immunoglobulin-associated alpha); CD79a molecule, immunoglobulin-associated alpha; MB-1 membrane glycoprotein; ig-alpha; membrane-bound immunoglobulin-associated protein; surface IgM-associated protein", "tax_id": 9913, "disease": "", "pathway": " (bta:281674); (R-BTA-5690714); (R-BTA-983695)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "7963570;8810000", "class_list": "", "function": "Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts with and increases activity of some Src-family tyrosine kinases. Represses BCR signaling during development of immature B-cells (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q0P5B8;Q28134", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0005771 multivesicular body;GO:0019815 B cell receptor complex;GO:0071755 IgM B cell receptor complex", "go_biological_process": "GO:0042113 B cell activation;GO:0002250 adaptive immune response;GO:0050853 B cell receptor signaling pathway;GO:0030183 B cell differentiation;GO:0042100 B cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P40293-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40673-1", "uniprot_id": [ { "id": "HMGB2_BOVIN", "url": "https://www.uniprot.org/uniprot/P40673", "type": "external" } ], "mass": 24034.0, "length": 209, "protein_name": "High mobility group protein B2", "gene_name": "HMGB2", "organism": "Bovine", "refseq_name": "high mobility group protein B2", "refseq_ac": [ { "id": "NP_001032705", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032705", "type": "external" } ], "gene_names_uniprotkb": "HMGB2; HMG2", "gene_names_refseq": "HMGB2", "protein_names_uniprotkb": "High mobility group protein B2; HMG-2; High mobility group protein 2", "protein_names_refseq": "HMG-2; high mobility group protein 2; high mobility group protein B2", "tax_id": 9913, "disease": "", "pathway": " (bta:540444); (R-BTA-140342)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "15256536;2365081", "class_list": "", "function": "Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes (By similarity). Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (PubMed:15256536). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors. In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE. Has antimicrobial activity in gastrointestinal epithelial tissues. Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity. May play a role in germ cell differentiation. Involved in modulation of neurogenesis probably by regulation of neural stem proliferation. Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q32L56", "ec_number_list": [], "go_molecular_function": "GO:0008301 DNA binding, bending;GO:0003684 damaged DNA binding;GO:0003690 double-stranded DNA binding;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0000793 condensed chromosome", "go_biological_process": "GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006935 chemotaxis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P40673-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P40682-1", "uniprot_id": [ { "id": "VAS1_BOVIN", "url": "https://www.uniprot.org/uniprot/P40682", "type": "external" } ], "mass": 51781.0, "length": 468, "protein_name": "V-type proton ATPase subunit S1", "gene_name": "ATP6AP1", "organism": "Bovine", "refseq_name": "V-type proton ATPase subunit S1 precursor", "refseq_ac": [ { "id": "NP_787000", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787000", "type": "external" } ], "gene_names_uniprotkb": "ATP6AP1; ATP6IP1; ATP6S1", "gene_names_refseq": "ATP6AP1; ATP6IP1; Ac45", "protein_names_uniprotkb": "V-type proton ATPase subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit S1; Vacuolar proton pump subunit S1", "protein_names_refseq": "ATPase, H+ transporting, lysosomal interacting protein 1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit S1; V-type proton ATPase subunit S1 precursor; V-type proton ATPase subunit S1; vacuolar proton pump subunit S1", "tax_id": 9913, "disease": "", "pathway": " (bta:327687); (R-BTA-77387); (R-BTA-8980692); (R-BTA-917977); (R-BTA-983712)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "30573663;32764564;7929063", "class_list": "", "function": "Accessory subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32764564). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity (By similarity). Involved in membrane trafficking and Ca(2+)-dependent membrane fusion (By similarity). May play a role in the assembly of the V-type ATPase complex (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). In islets of Langerhans cells, may regulate the acidification of dense-core secretory granules (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 7, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 7, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 7, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0033176 proton-transporting V-type ATPase complex;GO:0005789 endoplasmic reticulum membrane;GO:0030665 clathrin-coated vesicle membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0030641 regulation of cellular pH;GO:0036295 cellular response to increased oxygen levels;GO:1902600 proton transmembrane transport;GO:0036035 osteoclast development", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P40682-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41361-1", "uniprot_id": [ { "id": "ANT3_BOVIN", "url": "https://www.uniprot.org/uniprot/P41361", "type": "external" } ], "mass": 52347.0, "length": 465, "protein_name": "Antithrombin-III", "gene_name": "SERPINC1", "organism": "Bovine", "refseq_name": "antithrombin-III precursor", "refseq_ac": [ { "id": "NP_001029870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029870", "type": "external" } ], "gene_names_uniprotkb": "SERPINC1; AT3", "gene_names_refseq": "AT3; SERPINC1", "protein_names_uniprotkb": "Antithrombin-III; ATIII; Serpin C1", "protein_names_refseq": "ATIII; antithrombin-III precursor; antithrombin-III; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1; serpin C1", "tax_id": 9913, "disease": "", "pathway": " (bta:540261)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12192009;1930634;8331659;8756699", "class_list": "", "function": "ATIII may be protective in HIV-1 disease by inhibiting HIV-1 replication, [RefSeq, PubMed]; Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q3SZQ7", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007596 blood coagulation;GO:0030193 regulation of blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P41361-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P41987-1", "uniprot_id": [ { "id": "CXA3_BOVIN", "url": "https://www.uniprot.org/uniprot/P41987", "type": "external" } ], "mass": 43611.0, "length": 407, "protein_name": "Gap junction alpha-3 protein", "gene_name": "GJA3", "organism": "Bovine", "refseq_name": "gap junction alpha-3 protein", "refseq_ac": [ { "id": "NP_001159768", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159768", "type": "external" } ], "gene_names_uniprotkb": "GJA3", "gene_names_refseq": "CXNJ1; GJA3", "protein_names_uniprotkb": "Gap junction alpha-3 protein; Connexin-44; Cx44", "protein_names_refseq": "connexin J1; connexin-44; cx44; gap junction alpha-3 protein; gap junction protein, alpha 3, 46kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:100140301); (R-BTA-190861)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "19883592;8088962", "class_list": "", "function": "AQP-0 and connexins can be segregated in the membrane by protein-lipid interactions as modified by AQP-0 homo-oligomerization, [RefSeq, PubMed]; Structural component of lens fiber gap junctions (PubMed:8088962). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:8088962)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0055077 gap junction hemi-channel activity;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007601 visual perception;GO:1990349 gap junction-mediated intercellular transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P41987-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P42201-1", "uniprot_id": [ { "id": "LYAM3_BOVIN", "url": "https://www.uniprot.org/uniprot/P42201", "type": "external" } ], "mass": 71229.0, "length": 646, "protein_name": "P-selectin", "gene_name": "SELP", "organism": "Bovine", "refseq_name": "P-selectin precursor", "refseq_ac": [ { "id": "NP_776608", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776608", "type": "external" } ], "gene_names_uniprotkb": "SELP", "gene_names_refseq": "SELP", "protein_names_uniprotkb": "P-selectin; CD62 antigen-like family member P; GMP-140; Granule membrane protein 140; LECAM3; Leukocyte-endothelial cell adhesion molecule 3; PADGEM; Platelet activation dependent granule-external membrane protein", "protein_names_refseq": "CD62 antigen-like family member P; GMP-140; LECAM3; P-selectin precursor; P-selectin; PADGEM; granule membrane protein 140; leukocyte-endothelial cell adhesion molecule 3; platelet activation dependent granule-external membrane protein; selectin P (granule membrane protein 140kDa, antigen CD62)", "tax_id": 9913, "disease": "", "pathway": " (bta:281486)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "27663375;28419109;7683458", "class_list": "", "function": "Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes (PubMed:7683458). Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG (By similarity). Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3) (By similarity)., [UniProtKB, PubMed, UniProtKB]; Five single nucleotide polymorphisms (SNPs) from different exons in selectin SELP, two in selectin SELL and one in selectin SELE were taken forward to genotyping in 337 Holstein Friesian heifers using PCR-RFLP. Publication Status: Online-Only, [RefSeq, PubMed]; SELP mediates the attachment of peripheral blood leukocytes to endothelium and provides novel evidence that its high polymorphism is likely to affect biological function. This may potentially influence leukocyte migration and fertility, both key to successful performance in dairy cows., [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0005178 integrin binding;GO:0005509 calcium ion binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0098609 cell-cell adhesion;GO:0034097 response to cytokine;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0050901 leukocyte tethering or rolling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P42201-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P43481-1", "uniprot_id": [ { "id": "KIT_BOVIN", "url": "https://www.uniprot.org/uniprot/P43481", "type": "external" } ], "mass": 109685.0, "length": 977, "protein_name": "Mast/stem cell growth factor receptor Kit", "gene_name": "KIT", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KIT", "gene_names_refseq": "", "protein_names_uniprotkb": "Mast/stem cell growth factor receptor Kit; 2.7.10.1; Proto-oncogene c-Kit; SCFR; Tyrosine-protein kinase Kit", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:280832); (R-BTA-1257604); (R-BTA-1433557); (R-BTA-1433559); (R-BTA-5673001); (R-BTA-6811558); (R-BTA-9856649)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "7512939", "class_list": "", "function": "Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1 (By similarity)., [UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 12, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046872 metal ion binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0019955 cytokine binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0005615 extracellular space;GO:0005911 cell-cell junction;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0002327 immature B cell differentiation;GO:0035162 embryonic hemopoiesis;GO:0038093 Fc receptor signaling pathway;GO:0006954 inflammatory response;GO:0007283 spermatogenesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P43481-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46194-1", "uniprot_id": [ { "id": "CP19A_BOVIN", "url": "https://www.uniprot.org/uniprot/P46194", "type": "external" } ], "mass": 58090.0, "length": 503, "protein_name": "Aromatase", "gene_name": "CYP19A1", "organism": "Bovine", "refseq_name": "aromatase", "refseq_ac": [ { "id": "NP_776730", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776730", "type": "external" } ], "gene_names_uniprotkb": "CYP19A1; CYP19", "gene_names_refseq": "CYP19A1; CYP19P1; CYP19", "protein_names_uniprotkb": "Aromatase; 1.14.14.14; CYPXIX; Cytochrome P-450AROM; Cytochrome P450 19A1; Estrogen synthase", "protein_names_refseq": "CYPXIX; P-450AROM; aromatase cytochrome P450; aromatase; cytochrome P-450AROM; cytochrome P450 19A1; cytochrome P450, family 19, subfamily A, polypeptide 1; estrogen synthase; estrogen synthetase", "tax_id": 9913, "disease": "", "pathway": " (bta:281740)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "24947985;29772405;30232641;31713287;31996328;7890178;8404644;9202222", "class_list": "", "function": "A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase)., [UniProtKB, UniProtKB]; In granulosa cells of dominant follicles the concentration of CYP19P1 mRNA was very low compared to CYP19A1 mRNA. CONCLUSIONS: CYP19P1 and CYP19A1 transcripts might interfere in placental cotyledons Publication Status: Online-Only, [RefSeq, PubMed]; MiR-326 down-regulate CYP19A1 expression and estradiol-17b production in buffalo granulosa cells through CREB and C/EBP-beta., [RefSeq, PubMed]; The CYP19A1 gene contributes to genetic variation of in vitro embryo production traits in cattle. The complexity of the physiological phenomena related to estrogen pathways and their influence on reproduction in cattle allow indication of the mutations evaluated here as possible genetic markers for embryo production traits, which should be validated in the next steps of marker-assisted selection., [RefSeq, PubMed]; These data suggest that posttranscriptional regulation is an important component of the control of CYP19A1 expression and involves protein binding to a specific sequence in the 3'UTR., [RefSeq, PubMed]; This study examined the calibration of follicular development in chickens and cattle according to gene expression patterns. Unlike mammals, ESR2 was implicated as one of transcription factors regulating CYP19A1 expression in chicken follicles., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29445;Q29453", "ec_number_list": [ { "id": "1.14.14.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.1", "type": "external" }, { "id": "1.14.14.14", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.14", "type": "external" } ], "go_molecular_function": "GO:0070330 aromatase activity;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0101021 estrogen 2-hydroxylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0032355 response to estradiol;GO:0006694 steroid biosynthetic process;GO:0008209 androgen metabolic process;GO:0008585 female gonad development", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P46194-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46196-1", "uniprot_id": [ { "id": "MK01_BOVIN", "url": "https://www.uniprot.org/uniprot/P46196", "type": "external" } ], "mass": 41376.0, "length": 360, "protein_name": "Mitogen-activated protein kinase 1", "gene_name": "MAPK1", "organism": "Bovine", "refseq_name": "mitogen-activated protein kinase 1", "refseq_ac": [ { "id": "NP_786987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786987", "type": "external" } ], "gene_names_uniprotkb": "MAPK1; ERK2; PRKM1", "gene_names_refseq": "ERK2; MAPK1", "protein_names_uniprotkb": "Mitogen-activated protein kinase 1; 2.7.11.24; ERK-2; ERT1; Extracellular signal-regulated kinase 2; MAP kinase 1; MAP kinase 2; MAPK 1; MAPK 2; Mitogen-activated protein kinase 2", "protein_names_refseq": "ERK-2; ERT1; MAP kinase 1; MAP kinase 2; MAPK 1; MAPK 2; extracellular signal-regulated kinase 2; mitogen-activated protein kinase 1; mitogen-activated protein kinase 2; p42-MAPK", "tax_id": 9913, "disease": "", "pathway": " (bta:327672); (R-BTA-111995); (R-BTA-112409); (R-BTA-1181150); (R-BTA-1295596); (R-BTA-1502540); (R-BTA-162658); (R-BTA-170968); (R-BTA-198753); (R-BTA-202670); (R-BTA-2029482); (R-BTA-2173795); (R-BTA-2173796); (R-BTA-2559580); (R-BTA-2559582); (R-BTA-2559585); (R-BTA-2871796); (R-BTA-3371453); (R-BTA-375165); (R-BTA-437239); (R-BTA-450341); (R-BTA-456926); (R-BTA-5654726); (R-BTA-5654727); (R-BTA-5654732); (R-BTA-5654733); (R-BTA-5663213); (R-BTA-5668599); (R-BTA-5673001); (R-BTA-5674135); (R-BTA-5674499); (R-BTA-5675221); (R-BTA-6798695); (R-BTA-6811558); (R-BTA-74749); (R-BTA-877300); (R-BTA-881907); (R-BTA-8939211); (R-BTA-9627069); (R-BTA-9634635); (R-BTA-9634638); (R-BTA-9732724); (R-BTA-982772); (R-BTA-9856649)", "pathway_count": 44, "publication_count": 9, "publication_id_list": "15078886;15304367;15501927;18008139;22140445;23271465;25500918;30385793;33813288", "class_list": "", "function": "Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity., [UniProtKB, UniProtKB]; Both granulosa and theca cells of ERK1/2-inhibited follicles had higher expression of SLC16A1, a monocarboxylate transporter, transporting substances including beta-hydroxybutyrate across the plasma membrane. Taken together, ERK1/2 plays a significant role in mediating LH surge-induced gene expression in granulosa and theca cells of the ovulating follicle in cattle. Publication Status: Online-Only, [RefSeq, PubMed]; Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling., [RefSeq, PubMed]; Data demonstrate that hypoxia-induced adventitial fibroblast proliferation requires activation and interaction of PI3K, Akt, mTOR, p70S6K, and ERK1/2., [RefSeq, PubMed]; Histamine triggers the formation of neutrophil extracellular traps via NADPH oxidase, ERK and p38 pathways., [RefSeq, PubMed]; MAPK1 upregulated milk protein synthesis through the Stat5 and mTOR pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Role of CaMKII in hydrogen peroxide activation of p38 MAPK/heat shock protein 27 pathway and ERK1/2, [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade also plays a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1 and FXR1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2, GLI1 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in response to EGF stimulation. May play a role in the spindle assembly checkpoint (By similarity). Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation. Phosphorylates CDK2AP2. Phosphorylates phosphoglycerate kinase PGK1 under hypoxic conditions to promote its targeting to the mitochondrion and suppress the formation of acetyl-coenzyme A from pyruvate (By similarity). Phosphorylates GJA1 at 'Ser-280' and 'Ser-283' resulting in an increase in GJA1 ubiquitination and ultimately lysosomal degradation (By similarity). Acts as a positive regulator of smoothened signaling by mediating phosphorylation of GLI1 in response to smoothened activation, promoting its dissociation from SUFU inhibitor and translocation to the nucleus (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The present results suggest that demecolcine might contribute to the activation of the Mos/MAPK pathway and affect spindle structure, [RefSeq, PubMed]; These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 nuclear accumulation., [RefSeq, PubMed]; This study demonstrates for the first time that cyclic mechanical stretch induces the proliferation of bovine satellite cells and suppresses their myogenic differentiation through the activation of ERK., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A2VE60", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "6.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.4", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "3.4.22.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.62", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": 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"external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005925 focal adhesion", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:1903955 positive regulation of protein targeting to mitochondrion;GO:0006915 apoptotic process;GO:0071456 cellular response to hypoxia", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P46196-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46198-1", "uniprot_id": [ { "id": "IF2M_BOVIN", "url": "https://www.uniprot.org/uniprot/P46198", "type": "external" } ], "mass": 81764.0, "length": 727, "protein_name": "Translation initiation factor IF-2, mitochondrial", "gene_name": "MTIF2", "organism": "Bovine", "refseq_name": "translation initiation factor IF-2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776818", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776818", "type": "external" } ], "gene_names_uniprotkb": "MTIF2", "gene_names_refseq": "MTIF2", "protein_names_uniprotkb": "Translation initiation factor IF-2, mitochondrial; IF-2(Mt); IF-2Mt; IF2(mt)", "protein_names_refseq": "IF-2(Mt); IF-2Mt; IF2(mt); translation initiation factor IF-2, mitochondrial precursor; translation initiation factor IF-2, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:281923)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "18243113;7711084;8621449", "class_list": "", "function": "Mitochondrial translation initiation factor that promotes binding of formylmethionyl-tRNA to the 30S ribosomal subunits (PubMed:8621449). Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)., [UniProtKB, PubMed, UniProtKB]; Single factor (IF2(mt)) in mammalian mitochondria performs the functions of two eubacterial factors, IF1 and IF2., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QR53", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0043024 ribosomal small subunit binding;GO:0008135 translation factor activity, RNA binding;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0070124 mitochondrial translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P46198-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P46282-1", "uniprot_id": [ { "id": "IL12B_BOVIN", "url": "https://www.uniprot.org/uniprot/P46282", "type": "external" } ], "mass": 37050.0, "length": 327, "protein_name": "Interleukin-12 subunit beta", "gene_name": "IL12B", "organism": "Bovine", "refseq_name": "interleukin-12 subunit beta precursor", "refseq_ac": [ { "id": "NP_776781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776781", "type": "external" } ], "gene_names_uniprotkb": "IL12B", "gene_names_refseq": "IL12B; IL12p40", "protein_names_uniprotkb": "Interleukin-12 subunit beta; CLMF p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p40; IL-12B", "protein_names_refseq": "CLMF p40; IL-12 subunit p40; IL-12B; cytotoxic lymphocyte maturation factor 40 kDa subunit; interleukin 12 40kDa subunit; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 subunit beta precursor; interleukin-12 subunit beta", "tax_id": 9913, "disease": "", "pathway": " (bta:281857); (R-BTA-9020591); (R-BTA-9020933)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "17530193;17727806;19022505;7727547", "class_list": "", "function": "Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of pro-inflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis (By similarity)., [UniProtKB]; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Lipopolysaccharide stimulation up-regulates the secretion of cytokines, including interleukin-12, by bovine polymorphonuclear neutrophil leukocytes., [RefSeq, PubMed]; Study investigated hypothesis that CD40 signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS and IL-12p40 genes downstream of p38, [RefSeq, PubMed]; The results showed that the expression of TNF-alpha, iNOS, and IL-6 in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6, IL-12], [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A9QWR4", "ec_number_list": [], "go_molecular_function": "GO:0005143 interleukin-12 receptor binding;GO:0042164 interleukin-12 alpha subunit binding;GO:0005125 cytokine activity;GO:0004896 cytokine receptor activity;GO:0045519 interleukin-23 receptor binding", "go_cellular_component": "GO:0043514 interleukin-12 complex;GO:0005615 extracellular space;GO:0016020 membrane;GO:0070743 interleukin-23 complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0035722 interleukin-12-mediated signaling pathway;GO:0032729 positive regulation of type II interferon production;GO:0042093 T-helper cell differentiation;GO:0042104 positive regulation of activated T cell proliferation;GO:0030101 natural killer cell activation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P46282-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P47865-1", "uniprot_id": [ { "id": "AQP1_BOVIN", "url": "https://www.uniprot.org/uniprot/P47865", "type": "external" } ], "mass": 28800.0, "length": 271, "protein_name": "Aquaporin-1", "gene_name": "AQP1", "organism": "Bovine", "refseq_name": "aquaporin-1", "refseq_ac": [ { "id": "NP_777127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777127", "type": "external" } ], "gene_names_uniprotkb": "AQP1", "gene_names_refseq": "AQP-1; AQP1; CHIP29", "protein_names_uniprotkb": "Aquaporin-1; AQP-1; Aquaporin-CHIP; Water channel protein CHIP29", "protein_names_refseq": "aquaporin 1 (Colton blood group); aquaporin-1; aquaporin-CHIP; water channel protein CHIP29; water channel protein for red blood cells and kidney proximal tubule", "tax_id": 9913, "disease": "", "pathway": " (bta:282653); (R-BTA-1237044); (R-BTA-1247673); (R-BTA-432040); (R-BTA-432047)", "pathway_count": 5, "publication_count": 7, "publication_id_list": "10957645;11780053;12498798;16305752;19961829;25659484;7526855", "class_list": "", "function": "Aquaporin-1 significantly contributes to hydrostatic pressure-driven water transport across aortic endothelial monolayers in culture., [RefSeq, PubMed]; Comparisons of free-energy and interaction-energy profiles for water conduction between AQP0 and AQP1 indicate that this interruption of the water chain causes a huge energy barrier opposing water translocation through AQP0., [RefSeq, PubMed]; Data present a detailed comparison between the cryo-electron microscopy and X-ray crystallography model structures of the human and bovine water channel aquaporin-1 (AQP1)., [RefSeq, PubMed]; Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues. Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q2HJE2", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0005267 potassium channel activity;GO:0005372 water transmembrane transporter activity;GO:0015168 glycerol transmembrane transporter activity;GO:0015250 water channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016323 basolateral plasma membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0019725 cellular homeostasis;GO:0043066 negative regulation of apoptotic process;GO:0071300 cellular response to retinoic acid;GO:0071320 cellular response to cAMP;GO:0045766 positive regulation of angiogenesis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P47865-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48034-1", "uniprot_id": [ { "id": "AOXA_BOVIN", "url": "https://www.uniprot.org/uniprot/P48034", "type": "external" } ], "mass": 147611.0, "length": 1339, "protein_name": "Aldehyde oxidase 1", "gene_name": "AOX1", "organism": "Bovine", "refseq_name": "aldehyde oxidase 1", "refseq_ac": [ { "id": "NP_788841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788841", "type": "external" } ], "gene_names_uniprotkb": "AOX1; AO", "gene_names_refseq": "AOX1", "protein_names_uniprotkb": "Aldehyde oxidase 1; 1.17.3.-; 1.2.3.1; Azaheterocycle hydroxylase 1", "protein_names_refseq": "aldehyde oxidase 1; azaheterocycle hydroxylase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:338074)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23263164;8537361", "class_list": "", "function": "Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis., [UniProtKB, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3MHE7", "ec_number_list": [ { "id": "1.2.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.3.1", "type": "external" }, { "id": "1.17.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.3.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding;GO:0004031 aldehyde oxidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48034-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48035-1", "uniprot_id": [ { "id": "FABP4_BOVIN", "url": "https://www.uniprot.org/uniprot/P48035", "type": "external" } ], "mass": 14678.0, "length": 132, "protein_name": "Fatty acid-binding protein, adipocyte", "gene_name": "FABP4", "organism": "Bovine", "refseq_name": "fatty acid-binding protein, adipocyte", "refseq_ac": [ { "id": "NP_776739", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776739", "type": "external" } ], "gene_names_uniprotkb": "FABP4", "gene_names_refseq": "FABP4", "protein_names_uniprotkb": "Fatty acid-binding protein, adipocyte; A-FABP; AFABP; ALBP; Adipocyte lipid-binding protein; Adipocyte-type fatty acid-binding protein; Fatty acid-binding protein 4", "protein_names_refseq": "A-FABP; AFABP; ALBP; adipocyte lipid-binding protein; adipocyte-type fatty acid-binding protein; fatty acid-binding protein, adipocyte", "tax_id": 9913, "disease": "", "pathway": " (bta:281759)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "16879357;18304447;19077218;26067182;26641034;26913550;28051918;32000870;8702709", "class_list": "", "function": "Effects of FABP4 variation on milk fatty-acid composition for dairy cattle grazed on pasture in late lactation., [RefSeq, PubMed]; FABP4 I74V polymorphism had a significant effect on palmitoleic acid composition in intramuscular fat. Publication Status: Online-Only, [RefSeq, PubMed]; Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus., [UniProtKB, UniProtKB]; Our findings suggest that the polymorphisms in FABP4 may play a role in determining one of the important genetic factors that influence back fat thickness in beef cattle., [RefSeq, PubMed]; Overexpressed FABP4 of different genotypes in bovine intramuscular preadipocytes and studied the intracellular localization of FABP4 and the expression levels of lipid metabolism-related genes among different genotypes., [RefSeq, PubMed]; Studied SNPs in cattle Fatty Acid Binding Protein 4 (FABP4) in several cattle breeds and evaluated possible associations with regards to meat quality and fat content of the meat., [RefSeq, PubMed]; The FABP4 gene falls into a suggestive/significant quantitative trait loci interval for beef marbling., [RefSeq, PubMed]; These results provide an important basis for further understanding the regulation of bovine FABP4., [RefSeq, PubMed]; This suggest that FABP4 affects milk yield and milk protein content, both economically important traits, and that further study of this gene is warranted. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0036041 long-chain fatty acid binding;GO:0005324 long-chain fatty acid transmembrane transporter activity;GO:0005504 fatty acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0008284 positive regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0010629 negative regulation of gene expression;GO:0050872 white fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P48035-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48616-1", "uniprot_id": [ { "id": "VIME_BOVIN", "url": "https://www.uniprot.org/uniprot/P48616", "type": "external" } ], "mass": 53728.0, "length": 466, "protein_name": "Vimentin", "gene_name": "VIM", "organism": "Bovine", "refseq_name": "vimentin", "refseq_ac": [ { "id": "NP_776394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776394", "type": "external" } ], "gene_names_uniprotkb": "VIM", "gene_names_refseq": "VIM", "protein_names_uniprotkb": "Vimentin", "protein_names_refseq": "vimentin", "tax_id": 9913, "disease": "", "pathway": " (bta:280955); (R-BTA-264870); (R-BTA-390522); (R-BTA-9013422); (R-BTA-9646399)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "15483223;16876394;19019059;8144034", "class_list": "", "function": "An intact vimentin intermediate filament network contributes to the maintenance of the chondrocyte phenotype, [RefSeq, PubMed]; Immunocytochemistry for Vimentin detection in nuclei of IVF and NT bovine embryos, [RefSeq, PubMed]; Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2., [UniProtKB, UniProtKB]; These results indicate that the inner mass differentiates dynamically in blastocysts, as reflected by the expression of vimentin; higher vimentin expression may reflect the higher developmental competence of embryos., [RefSeq, PubMed]; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. Plays a role in cell directional movement, orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Protects SCRIB from proteasomal degradation and facilitates its localization to intermediate filaments in a cell contact-mediated manner (By similarity). May promote axon outgrowth and motor fiber repair via DSP-mediated recruitment to outgrowth tips (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 36, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q17QM7", "ec_number_list": [], "go_molecular_function": "GO:1990254 keratin filament binding;GO:0005200 structural constituent of cytoskeleton;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0001701 in utero embryonic development;GO:0010628 positive regulation of gene expression;GO:0032930 positive regulation of superoxide anion generation;GO:0043488 regulation of mRNA stability;GO:0071222 cellular response to lipopolysaccharide", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P48616-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48733-1", "uniprot_id": [ { "id": "UROM_BOVIN", "url": "https://www.uniprot.org/uniprot/P48733", "type": "external" } ], "mass": 69898.0, "length": 643, "protein_name": "Uromodulin", "gene_name": "UMOD", "organism": "Bovine", "refseq_name": "uromodulin precursor", "refseq_ac": [ { "id": "NP_776638", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776638", "type": "external" } ], "gene_names_uniprotkb": "UMOD", "gene_names_refseq": "UMOD", "protein_names_uniprotkb": "Uromodulin; THP; Tamm-Horsfall urinary glycoprotein", "protein_names_refseq": "THP; tamm-Horsfall urinary glycoprotein; uromodulin (uromucoid, Tamm-Horsfall glycoprotein); uromodulin precursor; uromucoid, human : Tamm-Horsfall glycoprotein", "tax_id": 9913, "disease": "", "pathway": " (bta:281567)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12739887;7531049", "class_list": "", "function": "Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia., [UniProtKB, UniProtKB]; In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals. Protects against urinary tract infections by binding to type 1 fimbriated E.coli. Binds to bacterial adhesin fimH which mediates the stable formation of bacterial aggregates, prevents the binding of E.coli to uroplakins UPK1A and UPK1B which act as urothelial receptors for type I fimbriae, and allows for pathogen clearance through micturation. Also promotes aggregation of other bacteria including K.pneumoniae, P.aeruginosa and S.mitis and so may also protect against other uropathogens., [UniProtKB, UniProtKB]; Transgene expression was restricted to tubule epithelial cells of the loop of Henle in the kidney, [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005615 extracellular space;GO:0005929 cilium;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium;GO:1990266 neutrophil migration;GO:0140367 antibacterial innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48733-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48765-1", "uniprot_id": [ { "id": "NAC1_BOVIN", "url": "https://www.uniprot.org/uniprot/P48765", "type": "external" } ], "mass": 108027.0, "length": 970, "protein_name": "Sodium/calcium exchanger 1", "gene_name": "SLC8A1", "organism": "Bovine", "refseq_name": "sodium/calcium exchanger 1 precursor", "refseq_ac": [ { "id": "NP_788805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788805", "type": "external" } ], "gene_names_uniprotkb": "SLC8A1", "gene_names_refseq": "NCX1; SLC8A1", "protein_names_uniprotkb": "Sodium/calcium exchanger 1; Na(+)/Ca(2+)-exchange protein 1; Solute carrier family 8 member 1", "protein_names_refseq": "Na(+)/Ca(2+)-exchange protein 1; sodium-calcium exchanger; sodium/calcium exchanger 1 precursor; sodium/calcium exchanger 1; solute carrier family 8, member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:337925)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12502561;12502572;1416984;19094959;1929404;20372982;20576602;20933499;2334719;23506867", "class_list": "", "function": "A novel mechanism for the regulation of NCX1 activity, [RefSeq, PubMed]; Cleavage of NCX may be interpreted as the main cause of Ca(2+) overload and could lay a key role in activation of apoptotic processes in pulmonary smooth muscle., [RefSeq, PubMed]; Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1416984). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions., [UniProtKB, UniProtKB, PubMed]; Na/Ca exchanger's (NCX1) associates specifically with caveolin-3(NCX1)(caveolin-3), [RefSeq, PubMed]; The cleavage of NCX1 by m-calpain in the caveolae vesicles may be interpreted as an important mechanism of Ca(2+) overload, [RefSeq, PubMed]; The regulation of phosphatidylinositol-4,5-biphosphate binding to the bovine cardiac Na+/Ca2+ exchanger(NCX1), [RefSeq, PubMed]; These results indicate that, for a proper MgATP up-regulation of NCX1, the enzyme responsible for PtdIns-4,5P2 synthesis must be (i) functionally competent and (ii) set in the NCX1 microenvironment closely associated to the exchanger., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005509 calcium ion binding;GO:0005432 calcium:sodium antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0098794 postsynapse;GO:0005901 caveola;GO:0042383 sarcolemma", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0006816 calcium ion transport;GO:0006874 intracellular calcium ion homeostasis;GO:0051924 regulation of calcium ion transport;GO:0002028 regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P48765-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48818-1", "uniprot_id": [ { "id": "ACADV_BOVIN", "url": "https://www.uniprot.org/uniprot/P48818", "type": "external" } ], "mass": 70649.0, "length": 655, "protein_name": "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "gene_name": "ACADVL", "organism": "Bovine", "refseq_name": "very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_776919", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776919", "type": "external" } ], "gene_names_uniprotkb": "ACADVL; VLCAD", "gene_names_refseq": "ACADVL", "protein_names_uniprotkb": "Very long-chain specific acyl-CoA dehydrogenase, mitochondrial; 1.3.8.8; 1.3.8.9; Long-chain specific acyl-CoA dehydrogenase, mitochondrial; VLCAD", "protein_names_refseq": "VLCAD; acyl-coenzyme A dehydrogenase, very long chain; very long-chain specific acyl-CoA dehydrogenase, mitochondrial precursor; very long-chain specific acyl-CoA dehydrogenase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:282130); (R-BTA-77305)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16305752;25620159", "class_list": "", "function": "Bovine ACADVL gene had a significant effect on chest width (P<0.05), chest depth (P<0.05), and hip width (P<0.05) in the Qinchuan breed., [RefSeq, PubMed]; Catalyzes the first of the four reactions of the mitochondrial fatty acid beta-oxidation (FAO) pathway, which consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). The mitochondrial FAO pathway is the major energy-producing process in tissues and is performed through cycles of four consecutive reactions. Each FAO cycle shortens the fatty acyl-CoA by two carbons, yielding one acetyl-CoA (for the citric acid cycle), one FADH(2), and one NADH (which donate electrons to the respiratory chain for ATP production). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on fatty acyl-CoAs with saturated 12 to 24 carbons long primary chains, but can also catalyze monounsaturated fatty acids such as oleate ((9Z)-octadecenoate), (9Z)-hexadecenoate, and others. In addition, based on its established catalytic mechanism, and combined genetic interaction or mutant phenotype evidence, it is predicted to act also on substrates that have not been tested experimentally but are metabolized by mitochondrial FAO, including long-chain unsaturated fatty acids such as linoleate (9Z,12Z-octadecadienoate), linolenate (9Z,12Z,15Z-octadecatrienoate), and others. Among the different mitochondrial acyl-CoA dehydrogenases, its FAO activity overlaps with that of ACAD9 and ACADL, but plays a primary role in tissues where it is the main long-chain ACAD expressed., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D9C7;Q3SZ66", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.9", "type": "external" } ], "go_molecular_function": "GO:0003995 acyl-CoA dehydrogenase activity;GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity;GO:0042802 identical protein binding;GO:0050660 flavin adenine dinucleotide binding;GO:0000062 fatty-acyl-CoA binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P48818-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48820-1", "uniprot_id": [ { "id": "RBP2_BOVIN", "url": "https://www.uniprot.org/uniprot/P48820", "type": "external" } ], "mass": 120456.0, "length": 1085, "protein_name": "E3 SUMO-protein ligase RanBP2", "gene_name": "RANBP2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RANBP2", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 SUMO-protein ligase RanBP2; 2.3.2.-; 358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2; RanBP2; p270", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7559465", "class_list": "", "function": "E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Binds single-stranded RNA (in vitro). May bind DNA. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Inhibits EIF4E-dependent mRNA export. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 20, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q28091", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0016740 transferase activity;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0031965 nuclear membrane", "go_biological_process": "GO:0015031 protein transport;GO:0016925 protein sumoylation;GO:0006457 protein folding;GO:0051028 mRNA transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P48820-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P48830-1", "uniprot_id": [ { "id": "ZP3_BOVIN", "url": "https://www.uniprot.org/uniprot/P48830", "type": "external" } ], "mass": 46545.0, "length": 421, "protein_name": "Zona pellucida sperm-binding protein 3", "gene_name": "ZP3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ZP3; ZPC", "gene_names_refseq": "", "protein_names_uniprotkb": "Zona pellucida sperm-binding protein 3; Sperm receptor; Zona pellucida glycoprotein 3B; Zona pellucida glycoprotein 3; Zona pellucida protein C; Zp-3B; Zp-3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7841460", "class_list": "", "function": "Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 4, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035804 structural constituent of egg coat;GO:0032190 acrosin binding;GO:0030246 carbohydrate binding;GO:0048018 receptor ligand activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0032991 protein-containing complex;GO:0035805 egg coat", "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:2000386 positive regulation of ovarian follicle development;GO:0035803 egg coat formation;GO:0007339 binding of sperm to zona pellucida;GO:0002455 humoral immune response mediated by circulating immunoglobulin", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P48830-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P50595-1", "uniprot_id": [ { "id": "LEP_BOVIN", "url": "https://www.uniprot.org/uniprot/P50595", "type": "external" } ], "mass": 18716.0, "length": 167, "protein_name": "Leptin", "gene_name": "LEP", "organism": "Bovine", "refseq_name": "leptin precursor", "refseq_ac": [ { "id": "NP_776353", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776353", "type": "external" } ], "gene_names_uniprotkb": "LEP; OBS; OB", "gene_names_refseq": "LEP; ob", "protein_names_uniprotkb": "Leptin; Obesity factor", "protein_names_refseq": "leptin precursor; obese; obesity factor", "tax_id": 9913, "disease": "", "pathway": " (bta:280836)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "10594237;14629116;16305752;27706683;28177355;28705737;31230519;33694014;8661738", "class_list": "", "function": "A leptin SNP (LEPg.978) was significantly associated with a weight at one year. Publication Status: Online-Only, [RefSeq, PubMed]; Consistent with this, leptin enhanced GnRH-induced secretion of LH measured by ELISA. We suggest that leptin enhances membrane expression of voltage-gated Na(+) and Ca(2+) channels, which results in a modulation of the action potential properties and an increase in hormone release from gonadotropes., [RefSeq, PubMed]; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity (By similarity). In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides (By similarity). In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption (By similarity). Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways (By similarity). May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 which promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38 (By similarity). In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses (By similarity). Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; LEP and SCD polymorphisms are associated with milk somatic cell count, electrical conductivity and pH values in Holstein cows., [RefSeq, PubMed]; Single nucleotide polymorphisms of leptin gene in five Ethiopian indigenous cattle breeds and the Korean Hanwoo breed. Publication Status: Online-Only, [RefSeq, PubMed]; The effects of a single nucleotide polymorphism of leptin on weight gain and body composition are reported., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97918;Q5EAE4;Q95133;Q9TSZ9", "ec_number_list": [], "go_molecular_function": "GO:0005179 hormone activity;GO:1990460 leptin receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0019953 sexual reproduction;GO:0006629 lipid metabolic process;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006909 phagocytosis", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "P50595-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51143-1", "uniprot_id": [ { "id": "SC6A2_BOVIN", "url": "https://www.uniprot.org/uniprot/P51143", "type": "external" } ], "mass": 68900.0, "length": 615, "protein_name": "Sodium-dependent noradrenaline transporter", "gene_name": "SLC6A2", "organism": "Bovine", "refseq_name": "sodium-dependent noradrenaline transporter", "refseq_ac": [ { "id": "NP_777033", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777033", "type": "external" } ], "gene_names_uniprotkb": "SLC6A2; NORADR", "gene_names_refseq": "SLC6A2", "protein_names_uniprotkb": "Sodium-dependent noradrenaline transporter; NET; Norepinephrine transporter; Solute carrier family 6 member 2", "protein_names_refseq": "NET; norepinephrine transporter; sodium-dependent noradrenaline transporter; solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282363)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7823028;8150077", "class_list": "", "function": "Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system (PubMed:8150077). Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis (By similarity). Can also mediate sodium- and chloride-dependent transport of dopamine (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005328 neurotransmitter:sodium symporter activity;GO:0005334 norepinephrine:sodium symporter activity;GO:0046872 metal ion binding;GO:0005330 dopamine:sodium symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0032809 neuronal cell body membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0035725 sodium ion transmembrane transport;GO:0015874 norepinephrine transport;GO:0051583 dopamine uptake involved in synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51143-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51176-1", "uniprot_id": [ { "id": "TGM2_BOVIN", "url": "https://www.uniprot.org/uniprot/P51176", "type": "external" } ], "mass": 77112.0, "length": 687, "protein_name": "Protein-glutamine gamma-glutamyltransferase 2", "gene_name": "TGM2", "organism": "Bovine", "refseq_name": "protein-glutamine gamma-glutamyltransferase 2", "refseq_ac": [ { "id": "NP_803473", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803473", "type": "external" } ], "gene_names_uniprotkb": "TGM2", "gene_names_refseq": "TGM2; TG", "protein_names_uniprotkb": "Protein-glutamine gamma-glutamyltransferase 2; 2.3.1.-; 2.3.2.13; 3.4.-.-; 3.5.1.44; Isopeptidase TGM2; Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; TGase-2; TG; Tissue transglutaminase; Transglutaminase-2", "protein_names_refseq": "TG(C); TGC; TGase C; TGase-2; isopeptidase TGM2; protein-glutamine deamidase TGM2; protein-glutamine dopaminyltransferase TGM2; protein-glutamine gamma-glutamyltransferase 2; protein-glutamine histaminyltransferase TGM2; protein-glutamine noradrenalinyltransferase TGM2; protein-glutamine serotonyltransferase TGM2; tissue transglutaminase; transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase); transglutaminase C", "tax_id": 9913, "disease": "", "pathway": " (bta:281528)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15691824;1682150;25128524;25218191;2572599;9880554", "class_list": "", "function": "An important role for TG2, mediated by intracellular calcium fluxes and HIF1A, in hypoxia-induced pulmonary artery smooth muscle cells proliferation., [RefSeq, PubMed]; Calcium-dependent acyltransferase that catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, such as gamma-amino group of peptide-bound lysine, or mono- and polyamines, thereby producing cross-linked or aminated proteins, respectively (By similarity). Involved in many biological processes, such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification and apoptosis (PubMed:9880554). Acts as a protein-glutamine gamma-glutamyltransferase by mediating the cross-linking of proteins, such as ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1 and WDR54 (PubMed:9880554). Under physiological conditions, the protein cross-linking activity is inhibited by GTP; inhibition is relieved by Ca(2+) in response to various stresses (By similarity). When secreted, catalyzes cross-linking of proteins of the extracellular matrix, such as FN1 and SPP1 resulting in the formation of scaffolds (By similarity). Plays a key role during apoptosis, both by (1) promoting the cross-linking of cytoskeletal proteins resulting in condensation of the cytoplasm, and by (2) mediating cross-linking proteins of the extracellular matrix, resulting in the irreversible formation of scaffolds that stabilize the integrity of the dying cells before their clearance by phagocytosis, thereby preventing the leakage of harmful intracellular components (By similarity). In addition to protein cross-linking, can use different monoamine substrates to catalyze a vast array of protein post-translational modifications: mediates aminylation of serotonin, dopamine, noradrenaline or histamine into glutamine residues of target proteins to generate protein serotonylation, dopaminylation, noradrenalinylation or histaminylation, respectively (PubMed:25128524). Mediates protein serotonylation of small GTPases during activation and aggregation of platelets, leading to constitutive activation of these GTPases (By similarity). Plays a key role in chromatin organization by mediating serotonylation and dopaminylation of histone H3 (By similarity). Catalyzes serotonylation of 'Gln-5' of histone H3 (H3Q5ser) during serotonergic neuron differentiation, thereby facilitating transcription (By similarity). Acts as a mediator of neurotransmission-independent role of nuclear dopamine in ventral tegmental area (VTA) neurons: catalyzes dopaminylation of 'Gln-5' of histone H3 (H3Q5dop), thereby regulating relapse-related transcriptional plasticity in the reward system (By similarity). Regulates vein remodeling by mediating serotonylation and subsequent inactivation of ATP2A2/SERCA2 (By similarity). Also acts as a protein deamidase by mediating the side chain deamidation of specific glutamine residues of proteins to glutamate (By similarity). Catalyzes specific deamidation of protein gliadin, a component of wheat gluten in the diet (By similarity). May also act as an isopeptidase cleaving the previously formed cross-links (By similarity). Also able to participate in signaling pathways independently of its acyltransferase activity: acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity and is required for coupling alpha-1 adrenergic agonists to the stimulation of phosphoinositide lipid metabolism (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Externalized GTP-bound TG2 serves as a molecular switch for differentiation of chondrocytes to a hypertrophic, calcifying phenotype in a manner that does not require either TG2 transamidation activity or fibronectin binding, [RefSeq, PubMed]; TG2 contributes to 5-hydroxytryptamine-induced distal pulmonary artery smooth muscle cell proliferation via promotion of AKT signaling, likely via its serotonylation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBH7", "ec_number_list": [ { "id": "2.3.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13", "type": "external" }, { "id": "3.5.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005525 GTP binding;GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0003810 protein-glutamine gamma-glutamyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000785 chromatin", "go_biological_process": "GO:0051057 positive regulation of small GTPase mediated signal transduction;GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0051260 protein homooligomerization;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P51176-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51186-1", "uniprot_id": [ { "id": "CAN3_BOVIN", "url": "https://www.uniprot.org/uniprot/P51186", "type": "external" } ], "mass": 94603.0, "length": 822, "protein_name": "Calpain-3", "gene_name": "CAPN3", "organism": "Bovine", "refseq_name": "calpain-3", "refseq_ac": [ { "id": "NP_776685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776685", "type": "external" } ], "gene_names_uniprotkb": "CAPN3; NCL1", "gene_names_refseq": "CAPN3; SKM-CALP", "protein_names_uniprotkb": "Calpain-3; 3.4.22.54; CANP 3; Calcium-activated neutral proteinase 3; Calpain L3; Calpain p94; Muscle-specific calcium-activated neutral protease 3; New calpain 1; nCL-1", "protein_names_refseq": "CANP 3; calcium-activated neutral proteinase 3; calpain 3, (p94); calpain L3; calpain p94; calpain-3; muscle-specific calcium-activated neutral protease 3; nCL-1; new calpain 1; skeletal muscle-specific calpain", "tax_id": 9913, "disease": "", "pathway": " (bta:281663)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "10612236;11204692;18590576;20421977;22367069;25729979;32827763", "class_list": "", "function": "2 CAPN3 transcripts in the skeletal muscle individuals of local black cattle from Jilin, China, were identified. Publication Status: Online-Only, [RefSeq, PubMed]; A QTL for meat tenderness is located in the Calpain 3 region of bovine chromosome 10. Publication Status: Online-Only, [RefSeq, PubMed]; Activated Capn3 may be involved in molecular pathways leading to the overexpression of E2F3, which in turn could be responsible for urothelial tumor cell proliferation Publication Status: Online-Only, [RefSeq, PubMed]; Bovine CAPN3 core promoter initiates expression of foreign genes in skeletal muscle cells by MyoD transcriptional regulation., [RefSeq, PubMed]; Calcium-regulated non-lysosomal thiol-protease. Proteolytically cleaves CTBP1. Mediates, with UTP25, the proteasome-independent degradation of p53/TP53., [UniProtKB, UniProtKB]; Calpain-system gene markers have beneficial effects on eating quality, consistent with previous findings for objective meat quality., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97700;Q9TTH9", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0003824 catalytic activity;GO:0008307 structural constituent of muscle", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0043066 negative regulation of apoptotic process;GO:0051592 response to calcium ion;GO:0045892 negative regulation of DNA-templated transcription;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P51186-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51490-1", "uniprot_id": [ { "id": "OPSB_BOVIN", "url": "https://www.uniprot.org/uniprot/P51490", "type": "external" } ], "mass": 39302.0, "length": 349, "protein_name": "Short-wave-sensitive opsin 1", "gene_name": "OPN1SW", "organism": "Bovine", "refseq_name": "short-wave-sensitive opsin 1", "refseq_ac": [ { "id": "NP_776992", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776992", "type": "external" } ], "gene_names_uniprotkb": "OPN1SW; BCP", "gene_names_refseq": "BCP; OPN1SW", "protein_names_uniprotkb": "Short-wave-sensitive opsin 1; BOP; Blue cone photoreceptor pigment; Blue-sensitive opsin", "protein_names_refseq": "BOP; blue cone photoreceptor pigment; blue-sensitive opsin; opsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan); short-wave-sensitive opsin 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282294); (R-BTA-2187335); (R-BTA-418594); (R-BTA-419771)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "8088841", "class_list": "", "function": "G protein-coupled photoreceptor that selectively activates G(i) proteins in response to short-wavelength (blue-violet) light, thereby decreasing intracellular cAMP levels. Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (By similarity). Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of cone photoreceptor function. Involved in ensuring the correct abundance and localization of retinal membrane proteins (By similarity). Mediates visual perception of blue light (By similarity). May contribute to increased spectral sensitivity under dim light conditions (By similarity). Is not UV-sensitive (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008020 G protein-coupled photoreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0001917 photoreceptor inner segment;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0016038 absorption of visible light;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007601 visual perception;GO:0007602 phototransduction;GO:0071492 cellular response to UV-A", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P51490-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51749-1", "uniprot_id": [ { "id": "CD40L_BOVIN", "url": "https://www.uniprot.org/uniprot/P51749", "type": "external" } ], "mass": 29243.0, "length": 261, "protein_name": "CD40 ligand", "gene_name": "CD40LG; LOC112445051", "organism": "Bovine", "refseq_name": "CD40 ligand", "refseq_ac": [ { "id": "NP_777049", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777049", "type": "external" } ], "gene_names_uniprotkb": "CD40LG; LOC112445051; CD40L; LOC112445051; TNFSF5", "gene_names_refseq": "CD40LG; TNFSF5", "protein_names_uniprotkb": "CD40 ligand; CD40-L; Tumor necrosis factor ligand superfamily member 5", "protein_names_refseq": "CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome); CD40 ligand; CD40-L; human : hyper-IgM syndrome; tumor necrosis factor (ligand) superfamily, member 5", "tax_id": 9913, "disease": "", "pathway": " (bta:282387)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "23761659;7590981", "class_list": "", "function": "Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results demonstrated greater CD40 and CD40L expression on fresh mononuclear leukocytes obtained from animals in the clinical stage of Johne's Disease., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0043539 protein serine/threonine kinase activator activity;GO:0005174 CD40 receptor binding;GO:0005164 tumor necrosis factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0030168 platelet activation;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P51749-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P51867-1", "uniprot_id": [ { "id": "TNR6_BOVIN", "url": "https://www.uniprot.org/uniprot/P51867", "type": "external" } ], "mass": 36445.0, "length": 323, "protein_name": "Tumor necrosis factor receptor superfamily member 6", "gene_name": "FAS", "organism": "Bovine", "refseq_name": "tumor necrosis factor receptor superfamily member 6 precursor", "refseq_ac": [ { "id": "NP_777087", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777087", "type": "external" } ], "gene_names_uniprotkb": "FAS; APT1; TNFRSF6", "gene_names_refseq": "APO1; FAS; TNFRSF6", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 6; Apo-1 antigen; Apoptosis-mediating surface antigen FAS; FASLG receptor", "protein_names_refseq": "FASLG receptor; Fas (TNF receptor superfamily, member 6); apo-1 antigen; apoptosis (APO-1) antigen 1 (FAS), member 6; apoptosis-mediating surface antigen FAS; tumor necrosis factor receptor superfamily member 6 precursor; tumor necrosis factor receptor superfamily, member 6", "tax_id": 9913, "disease": "", "pathway": " (bta:282488)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "15128594;16330085;23113883;24856470;8634151", "class_list": "", "function": "Activation of the Fas pathway and presence of FSH during in vitro maturation increased the incidence of apoptosis in cumulus cells, [RefSeq, PubMed]; Demonstrated for the first time that normal ejaculated spermatozoa express Fas antigen; data showed that a large percentage of normal ejaculated spermatozoa of fertile bulls are immunocytochemically positive for Fas, [RefSeq, PubMed]; Messenger RNA and protein levels of prostaglandin (PG) E synthase (PGES), PGF2alpha receptor (PGFR), tumor necrosis factor-alpha (TNF) and Fas were found to be higher in the corpus luteum of pregnancy than in corpus luteum of the cycle., [RefSeq, PubMed]; Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity)., [UniProtKB]; Results did not support that K8/K18 filaments influence the expression of Fas on the surface of luteal cells. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005031 tumor necrosis factor receptor activity;GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0045121 membrane raft;GO:0009897 external side of plasma membrane;GO:0031265 CD95 death-inducing signaling complex;GO:0009986 cell surface;GO:0005886 plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0043066 negative regulation of apoptotic process;GO:0097191 extrinsic apoptotic signaling pathway;GO:0006924 activation-induced cell death of T cells;GO:0097049 motor neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P51867-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P52193-1", "uniprot_id": [ { "id": "CALR_BOVIN", "url": "https://www.uniprot.org/uniprot/P52193", "type": "external" } ], "mass": 48039.0, "length": 417, "protein_name": "Calreticulin", "gene_name": "CALR", "organism": "Bovine", "refseq_name": "calreticulin precursor", "refseq_ac": [ { "id": "NP_776425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776425", "type": "external" } ], "gene_names_uniprotkb": "CALR; CRT", "gene_names_refseq": "CALR", "protein_names_uniprotkb": "Calreticulin; CRP55; Calregulin; HACBP", "protein_names_refseq": "CRP55; HACBP; calrectulin; calregulin; calreticulin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281036)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "12782144;15351734;2016321;8135753;8373827", "class_list": "", "function": "Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Found in extracellular matrix where it may play an important role in mineralization., [RefSeq, PubMed]; The lectin site of CRT is the main target for gentamicin binding, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P28489;P42918;Q8SQ53", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005829 cytosol;GO:0009986 cell surface;GO:0005789 endoplasmic reticulum membrane;GO:0033018 sarcoplasmic reticulum lumen;GO:0060473 cortical granule", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P52193-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53710-1", "uniprot_id": [ { "id": "ITA2_BOVIN", "url": "https://www.uniprot.org/uniprot/P53710", "type": "external" } ], "mass": 128929.0, "length": 1170, "protein_name": "Integrin alpha-2", "gene_name": "ITGA2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ITGA2", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; GPIa; Platelet membrane glycoprotein Ia; VLA-2 subunit alpha", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7511592", "class_list": "", "function": "Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix., [UniProtKB]", "predicted_glycosites": 12, "predicted_n_glycosites": 11, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 12, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0034666 integrin alpha2-beta1 complex", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P53710-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53712-1", "uniprot_id": [ { "id": "ITB1_BOVIN", "url": "https://www.uniprot.org/uniprot/P53712", "type": "external" } ], "mass": 88094.0, "length": 798, "protein_name": "Integrin beta-1", "gene_name": "ITGB1", "organism": "Bovine", "refseq_name": "integrin beta-1 precursor", "refseq_ac": [ { "id": "NP_776793", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776793", "type": "external" } ], "gene_names_uniprotkb": "ITGB1", "gene_names_refseq": "ITGB1", "protein_names_uniprotkb": "Integrin beta-1; Fibronectin receptor subunit beta; VLA-4 subunit beta", "protein_names_refseq": "fibronectin receptor subunit beta; integrin VLA-4 subunit beta; integrin beta-1 precursor; integrin beta-1; integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)", "tax_id": 9913, "disease": "", "pathway": " (bta:281876); (R-BTA-1566948); (R-BTA-1566977); (R-BTA-198933); (R-BTA-202733); (R-BTA-2129379); (R-BTA-216083); (R-BTA-2173789); (R-BTA-3000170); (R-BTA-3000178); (R-BTA-446343); (R-BTA-8874081); (R-BTA-8875513); (R-BTA-9013404); (R-BTA-9013408); (R-BTA-9013423); (R-BTA-9634597); (R-BTA-9860927)", "pathway_count": 18, "publication_count": 8, "publication_id_list": "12551988;15471980;16928957;17408410;19359599;19505962;24855102;7545439", "class_list": "", "function": "Both the gpIb-VWF interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II)beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound, [RefSeq, PubMed]; Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen., [RefSeq, PubMed]; Integrin activation with shear stress results in SFK-regulated caveolin-1 phosphorylation that, in turn, mediates Csk association at integrin sites, where it plays a role in downstream, shear-stimulated myosin light chain diphosphorylation., [RefSeq, PubMed]; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (By similarity). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (By similarity). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (By similarity). Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Putative function of fibronectin and its receptor (integrin alpha(5)beta(1)) in male and female gametes during bovine fertilization in vitro., [RefSeq, PubMed]; TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling., [RefSeq, PubMed]; The overall findings suggest that the secreted galectin-3 stimulated by PGF plays a role in structural luteolysis by binding to beta 1 integrin., [RefSeq, PubMed]", "predicted_glycosites": 13, "predicted_n_glycosites": 12, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "Q0PDN7;Q29RM8;Q8SQC0", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0019901 protein kinase binding;GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0001618 virus receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0009986 cell surface;GO:0016020 membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0007229 integrin-mediated signaling pathway;GO:0016477 cell migration;GO:0030335 positive regulation of cell migration;GO:0031623 receptor internalization;GO:0007160 cell-matrix adhesion", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P53712-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P53781-1", "uniprot_id": [ { "id": "TTP_BOVIN", "url": "https://www.uniprot.org/uniprot/P53781", "type": "external" } ], "mass": 34087.0, "length": 324, "protein_name": "mRNA decay activator protein ZFP36", "gene_name": "ZFP36", "organism": "Bovine", "refseq_name": "tristetraprolin", "refseq_ac": [ { "id": "NP_776918", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776918", "type": "external" } ], "gene_names_uniprotkb": "ZFP36", "gene_names_refseq": "TIS11; TTP; ZFP36", "protein_names_uniprotkb": "mRNA decay activator protein ZFP36; TTP; Tristetraprolin; Zfp-36; Zinc finger protein 36", "protein_names_refseq": "mRNA decay activator protein ZFP36; tristetraproline; tristetraprolin; zinc finger protein 36 homolog; zinc finger protein 36, C3H type, homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:282127)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "7559666", "class_list": "", "function": "Zinc-finger RNA-binding protein that destabilizes numerous cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation. Also functions by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs. Self regulates by destabilizing its own mRNA. Binds to 3'-UTR ARE of numerous mRNAs. Also binds to ARE of its own mRNA. Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages. Also plays a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response. Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia. Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA. Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA. Also associates with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs. Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs. May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro. Involved in the delivery of target ARE-mRNAs to processing bodies (PBs). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing. Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages. Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion. Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis. Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000900 mRNA regulatory element binding translation repressor activity;GO:0003677 DNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0032897 negative regulation of viral transcription;GO:0032703 negative regulation of interleukin-2 production;GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay;GO:1902172 regulation of keratinocyte apoptotic process;GO:1904582 positive regulation of intracellular mRNA localization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P53781-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P55156-1", "uniprot_id": [ { "id": "MTP_BOVIN", "url": "https://www.uniprot.org/uniprot/P55156", "type": "external" } ], "mass": 99032.0, "length": 887, "protein_name": "Microsomal triglyceride transfer protein large subunit", "gene_name": "MTTP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MTTP; MTP", "gene_names_refseq": "", "protein_names_uniprotkb": "Microsomal triglyceride transfer protein large subunit", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 4, "publication_id_list": "15897609;2351674;8361539;8876250", "class_list": "", "function": "Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:8876250). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (By similarity). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005548 phospholipid transporter activity;GO:0008289 lipid binding;GO:1902388 ceramide 1-phosphate transfer activity;GO:1904121 phosphatidylethanolamine transfer activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0042157 lipoprotein metabolic process;GO:0015914 phospholipid transport;GO:0042632 cholesterol homeostasis;GO:0009306 protein secretion;GO:0034197 triglyceride transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P55156-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56830-1", "uniprot_id": [ { "id": "IFNT2_BOVIN", "url": "https://www.uniprot.org/uniprot/P56830", "type": "external" } ], "mass": 19892.0, "length": 172, "protein_name": "Interferon tau-2", "gene_name": "IFNT2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "IFNT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Interferon tau-2; Antiluteolysin; IFN-tau-2; TP-1; Trophoblast antiluteolytic protein; Trophoblast protein 1; Trophoblastin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "11416010;8746786;9865498", "class_list": "", "function": "Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0007565 female pregnancy;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P56830-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56831-1", "uniprot_id": [ { "id": "IFNT3_BOVIN", "url": "https://www.uniprot.org/uniprot/P56831", "type": "external" } ], "mass": 19774.0, "length": 172, "protein_name": "Interferon tau-3", "gene_name": "IFNT3", "organism": "Bovine", "refseq_name": "interferon tau-3 precursor", "refseq_ac": [ { "id": "NP_001161747", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161747", "type": "external" } ], "gene_names_uniprotkb": "IFNT3", "gene_names_refseq": "IFNT3; IFNT", "protein_names_uniprotkb": "Interferon tau-3; Antiluteolysin; IFN-tau-3; TP-1; Trophoblast antiluteolytic protein; Trophoblast protein 1; Trophoblastin", "protein_names_refseq": "IFN-tau-3; IFN-tau3; TP-1; antiluteolysin; interferon tau-3 precursor; interferon tau; trophoblast antiluteolytic protein; trophoblast protein 1; trophoblastin", "tax_id": 9913, "disease": "", "pathway": " (bta:100313956)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "8746786;9865498", "class_list": "", "function": "Paracrine hormone primarily responsible for maternal recognition of pregnancy. Interacts with endometrial receptors, probably type I interferon receptors, and blocks estrogen receptor expression, preventing the estrogen-induced increase in oxytocin receptor expression in the endometrium. This results in the suppression of the pulsatile endometrial release of the luteolytic hormone prostaglandin F2-alpha, hindering the regression of the corpus luteum (luteolysis) and therefore a return to ovarian cyclicity. This, and a possible direct effect of IFN-tau on prostaglandin synthesis, leads in turn to continued ovarian progesterone secretion, which stimulates the secretion by the endometrium of the nutrients required for the growth of the conceptus. In summary, displays particularly high antiviral and antiproliferative potency concurrently with particular weak cytotoxicity, high antiluteolytic activity and immunomodulatory properties. In contrast with other IFNs, IFN-tau is not virally inducible., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9MZ09", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0007565 female pregnancy;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P56831-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P56966-1", "uniprot_id": [ { "id": "GGPPS_BOVIN", "url": "https://www.uniprot.org/uniprot/P56966", "type": "external" } ], "mass": 34900.0, "length": 300, "protein_name": "Geranylgeranyl pyrophosphate synthase", "gene_name": "GGPS1", "organism": "Bovine", "refseq_name": "geranylgeranyl pyrophosphate synthase", "refseq_ac": [ { "id": "NP_001073269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073269", "type": "external" } ], "gene_names_uniprotkb": "GGPS1", "gene_names_refseq": "GGPS1", "protein_names_uniprotkb": "Geranylgeranyl pyrophosphate synthase; (2E,6E)-farnesyl diphosphate synthase; 2.5.1.-; 2.5.1.10; 2.5.1.1; 2.5.1.29; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; GGPP synthase; GGPPSase; Geranylgeranyl diphosphate synthase; Geranyltranstransferase", "protein_names_refseq": "(2E,6E)-farnesyl diphosphate synthase; GGPP synthase; GGPP synthetase; GGPPSase; dimethylallyltranstransferase; farnesyl diphosphate synthase; farnesyltranstransferase; geranylgeranyl pyrophosphate synthase; geranylgeranyl pyrophosphate synthetase; geranyltranstransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:780882); (R-BTA-9969896)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "10026212", "class_list": "", "function": "Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VC78", "ec_number_list": [ { "id": "2.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.1", "type": "external" }, { "id": "2.5.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.10", "type": "external" }, { "id": "2.5.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.29", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0004161 dimethylallyltranstransferase activity;GO:0004337 (2E,6E)-farnesyl diphosphate synthase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0004311 geranylgeranyl diphosphate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0030018 Z disc", "go_biological_process": "GO:0033384 geranyl diphosphate biosynthetic process;GO:0045337 farnesyl diphosphate biosynthetic process;GO:0006720 isoprenoid metabolic process;GO:0033386 geranylgeranyl diphosphate biosynthetic process;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P56966-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58126-1", "uniprot_id": [ { "id": "KCNQ3_BOVIN", "url": "https://www.uniprot.org/uniprot/P58126", "type": "external" } ], "mass": 95645.0, "length": 866, "protein_name": "Potassium voltage-gated channel subfamily KQT member 3", "gene_name": "KCNQ3", "organism": "Bovine", "refseq_name": "potassium voltage-gated channel subfamily KQT member 3", "refseq_ac": [ { "id": "NP_776799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776799", "type": "external" } ], "gene_names_uniprotkb": "KCNQ3", "gene_names_refseq": "KCNQ3", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily KQT member 3; KQT-like 3; Potassium channel subunit alpha KvLQT3; Voltage-gated potassium channel subunit Kv7.3", "protein_names_refseq": "KQT-like 3; potassium channel subunit alpha KvLQT3; potassium voltage-gated channel subfamily KQT member 3; potassium voltage-gated channel, KQT-like subfamily, member 3; voltage-gated potassium channel subunit Kv7.3", "tax_id": 9913, "disease": "", "pathway": " (bta:281884); (R-BTA-1296072)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability. M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (By similarity). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+). Suppressed by activation of M1 muscarinic acetylcholine receptors. KCNQ3 also associates with KCNQ5 to form a functional channel in vitro and may also contribute to the M-current in brain (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005249 voltage-gated potassium channel activity;GO:0022843 voltage-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0008076 voltage-gated potassium channel complex;GO:0033268 node of Ranvier;GO:0043194 axon initial segment", "go_biological_process": "GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "P58126-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P58354-1", "uniprot_id": [ { "id": "SL2A8_BOVIN", "url": "https://www.uniprot.org/uniprot/P58354", "type": "external" } ], "mass": 51417.0, "length": 478, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 8", "gene_name": "SLC2A8", "organism": "Bovine", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 8", "refseq_ac": [ { "id": "NP_963286", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_963286", "type": "external" } ], "gene_names_uniprotkb": "SLC2A8; GLUT8; GLUTX1", "gene_names_refseq": "SLC2A8", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 8; GLUT-8; Glucose transporter type 8; Glucose transporter type X1", "protein_names_refseq": "GLUT-8; glucose transporter type 8; glucose transporter type X1; solute carrier family 2, (facilitated glucose transporter) member 8; solute carrier family 2, facilitated glucose transporter member 8", "tax_id": 9913, "disease": "", "pathway": " (bta:282867)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11599048;15488990", "class_list": "", "function": "Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose. Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1. Also able to mediate the transport of dehydroascorbate., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q1RMN1;Q6XUI2", "ec_number_list": [], "go_molecular_function": "GO:0033300 dehydroascorbic acid transmembrane transporter activity;GO:0005353 fructose transmembrane transporter activity;GO:0055056 D-glucose transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0015755 fructose transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P58354-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P60712-1", "uniprot_id": [ { "id": "ACTB_BOVIN", "url": "https://www.uniprot.org/uniprot/P60712", "type": "external" } ], "mass": 41737.0, "length": 375, "protein_name": "Actin, cytoplasmic 1", "gene_name": "ACTB", "organism": "Bovine", "refseq_name": "actin, cytoplasmic 1", "refseq_ac": [ { "id": "NP_776404", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776404", "type": "external" } ], "gene_names_uniprotkb": "ACTB", "gene_names_refseq": "ACTB", "protein_names_uniprotkb": "Actin, cytoplasmic 1; 3.6.4.-; Beta-actin", "protein_names_refseq": "actin, cytoplasmic 1; beta-actin", "tax_id": 9913, "disease": "", "pathway": " (bta:280979); (R-BTA-190873); (R-BTA-196025); (R-BTA-2029482); (R-BTA-3928662); (R-BTA-418990); (R-BTA-4420097); (R-BTA-446353); (R-BTA-5626467); (R-BTA-5663213); (R-BTA-5663220); (R-BTA-5674135); (R-BTA-8856828); (R-BTA-9013418); (R-BTA-9764561); (R-BTA-9913351); (R-BTA-9953170); (R-BTA-9958825)", "pathway_count": 18, "publication_count": 8, "publication_id_list": "14559974;16305752;213279;23220175;41018975;6195151;8413665;8918942", "class_list": "", "function": "Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (By similarity). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (By similarity). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (By similarity). Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments (By similarity). Part of the ACTR1A/ACTB filament around which the dynactin complex is built (By similarity). The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Taken together, these data can be explained by a model that associates components of the secretory machinery to the F-actin cortex through flexible links, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D961;A5PKA1;P02570;P70514;P99021;Q11211;Q3SZD2;Q64316;Q8MIJ0", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity;GO:0019894 kinesin binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0044305 calyx of Held;GO:0098871 postsynaptic actin cytoskeleton;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0007409 axonogenesis;GO:0001738 morphogenesis of a polarized epithelium;GO:1903076 regulation of protein localization to plasma membrane;GO:0048870 cell motility;GO:0007163 establishment or maintenance of cell polarity", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P60712-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P61635-1", "uniprot_id": [ { "id": "STAT3_BOVIN", "url": "https://www.uniprot.org/uniprot/P61635", "type": "external" } ], "mass": 87975.0, "length": 770, "protein_name": "Signal transducer and activator of transcription 3", "gene_name": "STAT3", "organism": "Bovine", "refseq_name": "signal transducer and activator of transcription 3", "refseq_ac": [ { "id": "NP_001012689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012689", "type": "external" } ], "gene_names_uniprotkb": "STAT3", "gene_names_refseq": "STAT3", "protein_names_uniprotkb": "Signal transducer and activator of transcription 3", "protein_names_refseq": "signal transducer and activator of transcription 3 (acute-phase response factor); signal transducer and activator of transcription 3", "tax_id": 9913, "disease": "", "pathway": " (bta:508541)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12419823;12637510;16257644;18378570;26400355;26813342;28337827;28917653;29596388;30068990", "class_list": "", "function": "Peroxynitrite causes increased expression of VEGF in vascular endothelial cells by a process that requires the activation of STAT3, [RefSeq, PubMed]; Results show for the first time that interleukin-6 (IL), in the presence of its soluble receptor (sIL-6R), induces activation of JAK1, JAK2, and STAT1/STAT3 proteins in bovine articular chondrocytes, [RefSeq, PubMed]; Role of shear flow in attenuating activation in endothelial cells, [RefSeq, PubMed]; STA3 facilitates TLR4-dependent IL-6 and IL-8 production via IL-6 receptor-positive feedback in endometrial cells., [RefSeq, PubMed]; STAT3 might have potential effects on production traits in beef cattle populations and could be used for marker-assisted selection. Publication Status: Online-Only, [RefSeq, PubMed]; Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (By similarity). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transctivating BIRC5 expression under LEP activation (By similarity). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (By similarity). Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Simvastatin protects against the early signs of diabetic retinopathy by preventing NADPH oxidase-mediated activation of STAT3., [RefSeq, PubMed]; Thus, activation of STAT3 and inactivation of AKT signaling are involved in structural regression of the corpus luteum., [RefSeq, PubMed]; Together these studies represent the first investigation of STAT3 signaling that directly influence miR-21 expression in bovine oocytes and cumulus cells. Publication Status: Online-Only, [RefSeq, PubMed]; Variations in the STAT3 gene promoter regions, most notably haplotype H3H3, may benefit marker-assisted breeding of Qinchuan cattle. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0046983 protein dimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0090575 RNA polymerase II transcription regulator complex", "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0001659 temperature homeostasis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006952 defense response", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "P61635-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62833-1", "uniprot_id": [ { "id": "RAP1A_BOVIN", "url": "https://www.uniprot.org/uniprot/P62833", "type": "external" } ], "mass": 20987.0, "length": 184, "protein_name": "Ras-related protein Rap-1A", "gene_name": "RAP1A", "organism": "Bovine", "refseq_name": "ras-related protein Rap-1A", "refseq_ac": [ { "id": "NP_776873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776873", "type": "external" } ], "gene_names_uniprotkb": "RAP1A", "gene_names_refseq": "RAP1A", "protein_names_uniprotkb": "Ras-related protein Rap-1A; 3.6.5.2; GTP-binding protein smg p21A", "protein_names_refseq": "GTP-binding protein smg p21A; ras-related protein Rap-1A", "tax_id": 9913, "disease": "", "pathway": " (bta:282031); (R-BTA-170968); (R-BTA-170984); (R-BTA-354192); (R-BTA-354194); (R-BTA-372708); (R-BTA-381676); (R-BTA-392517); (R-BTA-5674135); (R-BTA-6798695); (R-BTA-8875555)", "pathway_count": 11, "publication_count": 3, "publication_id_list": "1646988;17954608;3143720", "class_list": "", "function": "Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (By similarity). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions (By similarity)., [UniProtKB, UniProtKB]; Rap1 increases KRIT-1 targeting to endothelial cell-cell junctions where it suppresses stress fibers and stabilizes junctional integrity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IFG1;P10113", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0044877 protein-containing complex binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0030054 cell junction", "go_biological_process": "GO:2000301 negative regulation of synaptic vesicle exocytosis;GO:0061028 establishment of endothelial barrier;GO:0032486 Rap protein signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P62833-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62935-1", "uniprot_id": [ { "id": "PPIA_BOVIN", "url": "https://www.uniprot.org/uniprot/P62935", "type": "external" } ], "mass": 17869.0, "length": 164, "protein_name": "Peptidyl-prolyl cis-trans isomerase A", "gene_name": "PPIA", "organism": "Bovine", "refseq_name": "peptidyl-prolyl cis-trans isomerase A", "refseq_ac": [ { "id": "NP_847890", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_847890", "type": "external" } ], "gene_names_uniprotkb": "PPIA", "gene_names_refseq": "PPIA", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase A; 5.2.1.8; Cyclophilin A; Cyclosporin A-binding protein; PPIase A; Rotamase A", "protein_names_refseq": "PPIase A; cyclophilin A; cyclophilin T-cell; cyclophilin T; cyclosporin A-binding protein; peptidyl-prolyl cis-trans isomerase A; peptidylprolyl isomerase A (cyclophilin A); rotamase A", "tax_id": 9913, "disease": "", "pathway": " (bta:281418); (R-BTA-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "3522572", "class_list": "", "function": "Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation (By similarity). Activates endothelial cells (ECs) in a proinflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 (By similarity). Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis (By similarity). In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 (By similarity). Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 (By similarity). Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates (By similarity). Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P04374;P10110;Q29580;Q56JX4", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0005178 integrin binding;GO:1904399 heparan sulfate binding;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:2001233 regulation of apoptotic signaling pathway;GO:0001934 positive regulation of protein phosphorylation;GO:0043410 positive regulation of MAPK cascade;GO:0001933 negative regulation of protein phosphorylation;GO:0006469 negative regulation of protein kinase activity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P62935-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P62992-1", "uniprot_id": [ { "id": "RS27A_BOVIN", "url": "https://www.uniprot.org/uniprot/P62992", "type": "external" } ], "mass": 17965.0, "length": 156, "protein_name": "Ubiquitin-ribosomal protein eS31 fusion protein", "gene_name": "RPS27A", "organism": "Bovine", "refseq_name": "ubiquitin-ribosomal protein eS31 fusion protein", "refseq_ac": [ { "id": "NP_777203", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777203", "type": "external" } ], "gene_names_uniprotkb": "RPS27A; UBA80; UBCEP1", "gene_names_refseq": "RPS27A", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eS31 fusion protein; 40S ribosomal protein S27a; Ubiquitin carboxyl extension protein 80", "protein_names_refseq": "40S ribosomal protein S27a; ubiquitin carboxyl extension protein 80; ubiquitin-40S ribosomal protein S27a; ubiquitin-ribosomal protein eS31 fusion protein", "tax_id": 9913, "disease": "", "pathway": " (bta:286839); (R-BTA-110312); (R-BTA-110314); (R-BTA-110320); (R-BTA-1169091); (R-BTA-1234176); (R-BTA-1253288); (R-BTA-1295596); (R-BTA-1358803); (R-BTA-168638); (R-BTA-174048); (R-BTA-174084); (R-BTA-174113); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-179409); (R-BTA-182971); (R-BTA-187577); (R-BTA-195253); (R-BTA-201681); (R-BTA-202424); (R-BTA-205043); (R-BTA-209543); (R-BTA-209560); (R-BTA-2122948); (R-BTA-2173788); (R-BTA-2173791); (R-BTA-2173795); (R-BTA-2173796); (R-BTA-2467813); (R-BTA-2559582); (R-BTA-2672351); (R-BTA-2871837); (R-BTA-3134975); (R-BTA-349425); (R-BTA-3769402); (R-BTA-382556); (R-BTA-445989); (R-BTA-450302); (R-BTA-450321); (R-BTA-450408); (R-BTA-4608870); (R-BTA-4641257); (R-BTA-4641258); (R-BTA-4641263); (R-BTA-5205685); (R-BTA-532668); (R-BTA-5357905); (R-BTA-5357956); (R-BTA-5358346); (R-BTA-5607761); (R-BTA-5607764); (R-BTA-5610780); (R-BTA-5610785); (R-BTA-5632684); (R-BTA-5654726); (R-BTA-5654727); (R-BTA-5654732); (R-BTA-5654733); (R-BTA-5655862); (R-BTA-5656121); (R-BTA-5656169); (R-BTA-5668541); (R-BTA-5675221); (R-BTA-5675482); (R-BTA-5676590); (R-BTA-5684264); (R-BTA-5685942); (R-BTA-5687128); (R-BTA-5689603); (R-BTA-5689877); (R-BTA-5689880); (R-BTA-5689896); (R-BTA-5689901); (R-BTA-5693537); (R-BTA-5693565); (R-BTA-5693607); (R-BTA-5696394); (R-BTA-5696395); (R-BTA-5696397); (R-BTA-5696400); (R-BTA-6781823); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-6783310); (R-BTA-6804756); (R-BTA-6804757); (R-BTA-6804760); (R-BTA-6807004); (R-BTA-68867); (R-BTA-68949); (R-BTA-69017); (R-BTA-69231); (R-BTA-69481); (R-BTA-69601); (R-BTA-75815); (R-BTA-8849469); (R-BTA-8852276); (R-BTA-8854050); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-8863795); (R-BTA-8866427); (R-BTA-8866652); (R-BTA-8866654); (R-BTA-8939236); (R-BTA-8939902); (R-BTA-8941858); (R-BTA-8948747); (R-BTA-8948751); (R-BTA-8951664); (R-BTA-901032); (R-BTA-9010553); (R-BTA-9020702); (R-BTA-9033241); (R-BTA-909733); (R-BTA-912631); (R-BTA-917729); (R-BTA-917937); (R-BTA-936440); (R-BTA-936964); (R-BTA-937039); (R-BTA-937041); (R-BTA-937042); (R-BTA-937072); (R-BTA-9645460); (R-BTA-9646399); (R-BTA-9648002); (R-BTA-9664873); (R-BTA-9705462); (R-BTA-9706369); (R-BTA-9708530); (R-BTA-975144); (R-BTA-975163); (R-BTA-9755511); (R-BTA-9758274); (R-BTA-9762114); (R-BTA-9766229); (R-BTA-9770562); (R-BTA-9824878); (R-BTA-983168); (R-BTA-9861718); (R-BTA-9929356); (R-BTA-9929491); (R-BTA-9931269); (R-BTA-9931295); (R-BTA-9932298); (R-BTA-9954709); (R-BTA-9954716); (R-BTA-9958810)", "pathway_count": 151, "publication_count": 5, "publication_id_list": "1170880;12658628;1333954;6254502;9765411", "class_list": "", "function": "Component of the 40S subunit of the ribosome. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97577;P02248;P02249;P02250;P0CG52;P62990;P80169;Q01235;Q24K23;Q28169;Q28170;Q29120;Q3T0V5;Q3ZCE3;Q862C1;Q862F4;Q862M4;Q862T5;Q862X8;Q91887;Q91888", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0022626 cytosolic ribosome;GO:0032040 small-subunit processome", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006412 translation;GO:0019941 modification-dependent protein catabolic process;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P62992-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63048-1", "uniprot_id": [ { "id": "RL40_BOVIN", "url": "https://www.uniprot.org/uniprot/P63048", "type": "external" } ], "mass": 14728.0, "length": 128, "protein_name": "Ubiquitin-ribosomal protein eL40 fusion protein", "gene_name": "UBA52", "organism": "Bovine", "refseq_name": "ubiquitin-ribosomal protein eL40 fusion protein", "refseq_ac": [ { "id": "NP_001069831", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069831", "type": "external" } ], "gene_names_uniprotkb": "UBA52; UBCEP2", "gene_names_refseq": "RPS27A; UBA52; UBB; UBC", "protein_names_uniprotkb": "Ubiquitin-ribosomal protein eL40 fusion protein; 60S ribosomal protein L40; CEP52; Ubiquitin A-52 residue ribosomal protein fusion product 1", "protein_names_refseq": "60S ribosomal protein L40; CEP52; ubiquitin and ribosomal protein L40; ubiquitin-60S ribosomal protein L40; ubiquitin-ribosomal protein eL40 fusion protein", "tax_id": 9913, "disease": "", "pathway": " (bta:615199); (R-BTA-110312); (R-BTA-110314); (R-BTA-110320); (R-BTA-1169091); (R-BTA-1234176); (R-BTA-1253288); (R-BTA-1295596); (R-BTA-1358803); (R-BTA-156827); (R-BTA-168638); (R-BTA-174048); (R-BTA-174084); (R-BTA-174113); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-179409); (R-BTA-1799339); (R-BTA-182971); (R-BTA-187577); (R-BTA-195253); (R-BTA-201681); (R-BTA-202424); (R-BTA-205043); (R-BTA-209543); (R-BTA-209560); (R-BTA-2122948); (R-BTA-2173788); (R-BTA-2173791); (R-BTA-2173795); (R-BTA-2173796); (R-BTA-2467813); (R-BTA-2559582); (R-BTA-2672351); (R-BTA-2871837); (R-BTA-3134975); (R-BTA-349425); (R-BTA-3769402); (R-BTA-382556); (R-BTA-445989); (R-BTA-450302); (R-BTA-450321); (R-BTA-450408); (R-BTA-4608870); (R-BTA-4641257); (R-BTA-4641258); (R-BTA-4641263); (R-BTA-5205685); (R-BTA-532668); (R-BTA-5357905); (R-BTA-5357956); (R-BTA-5358346); (R-BTA-5607761); (R-BTA-5607764); (R-BTA-5610780); (R-BTA-5610785); (R-BTA-5632684); (R-BTA-5654726); (R-BTA-5654727); (R-BTA-5654732); (R-BTA-5654733); (R-BTA-5655862); (R-BTA-5656121); (R-BTA-5656169); (R-BTA-5668541); (R-BTA-5675221); (R-BTA-5675482); (R-BTA-5676590); (R-BTA-5684264); (R-BTA-5685942); (R-BTA-5687128); (R-BTA-5689603); (R-BTA-5689877); (R-BTA-5689880); (R-BTA-5689896); (R-BTA-5689901); (R-BTA-5693537); (R-BTA-5693565); (R-BTA-5693607); (R-BTA-5696394); (R-BTA-5696395); (R-BTA-5696397); (R-BTA-5696400); (R-BTA-6781823); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-6783310); (R-BTA-6791226); (R-BTA-6804756); (R-BTA-6804757); (R-BTA-6804760); (R-BTA-6807004); (R-BTA-68867); (R-BTA-68949); (R-BTA-69017); (R-BTA-69231); (R-BTA-69481); (R-BTA-69601); (R-BTA-72689); (R-BTA-72706); (R-BTA-75815); (R-BTA-8849469); (R-BTA-8852276); (R-BTA-8854050); (R-BTA-8856825); (R-BTA-8856828); (R-BTA-8863795); (R-BTA-8866427); (R-BTA-8866652); (R-BTA-8866654); (R-BTA-8939236); (R-BTA-8939902); (R-BTA-8941858); (R-BTA-8948747); (R-BTA-8948751); (R-BTA-8951664); (R-BTA-901032); (R-BTA-9010553); (R-BTA-9020702); (R-BTA-9033241); (R-BTA-909733); (R-BTA-912631); (R-BTA-917729); (R-BTA-917937); (R-BTA-936440); (R-BTA-936964); (R-BTA-937039); (R-BTA-937041); (R-BTA-937042); (R-BTA-937072); (R-BTA-9645460); (R-BTA-9646399); (R-BTA-9648002); (R-BTA-9664873); (R-BTA-9705462); (R-BTA-9706369); (R-BTA-9708530); (R-BTA-975144); (R-BTA-975163); (R-BTA-9755511); (R-BTA-9758274); (R-BTA-975956); (R-BTA-975957); (R-BTA-9762114); (R-BTA-9766229); (R-BTA-9770562); (R-BTA-9824878); (R-BTA-983168); (R-BTA-9861718); (R-BTA-9929356); (R-BTA-9929491); (R-BTA-9931269); (R-BTA-9931295); (R-BTA-9932298); (R-BTA-9954709); (R-BTA-9954714); (R-BTA-9954716); (R-BTA-9958810)", "pathway_count": 159, "publication_count": 4, "publication_id_list": "1170880;12658628;1333954;6254502", "class_list": "", "function": "Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs., [UniProtKB, UniProtKB]; Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in proteotoxic stress response and cell cycle; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O97577;P02248;P02249;P02250;P62990;P80169;Q01235;Q24K23;Q28169;Q28170;Q29120;Q3T0V5;Q3ZCE3;Q862C1;Q862F4;Q862M4;Q862T5;Q862X8;Q91887;Q91888", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity", "go_cellular_component": "GO:0005634 nucleus;GO:0045202 synapse;GO:0022626 cytosolic ribosome;GO:0022625 cytosolic large ribosomal subunit", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0019941 modification-dependent protein catabolic process;GO:0002181 cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P63048-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63097-1", "uniprot_id": [ { "id": "GNAI1_BOVIN", "url": "https://www.uniprot.org/uniprot/P63097", "type": "external" } ], "mass": 40361.0, "length": 354, "protein_name": "Guanine nucleotide-binding protein G(i) subunit alpha-1", "gene_name": "GNAI1", "organism": "Bovine", "refseq_name": "guanine nucleotide-binding protein G(i) subunit alpha-1", "refseq_ac": [ { "id": "NP_776749", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776749", "type": "external" } ], "gene_names_uniprotkb": "GNAI1", "gene_names_refseq": "GNAI1; HG1B", "protein_names_uniprotkb": "Guanine nucleotide-binding protein G(i) subunit alpha-1; 3.6.5.-; Adenylate cyclase-inhibiting G alpha protein", "protein_names_refseq": "adenylate cyclase-inhibiting G alpha protein; guanine nucleotide-binding protein G(i) subunit alpha-1; guanine nucleotide-binding protein G(i), alpha-1 subunit; heterotrimeric guanine nucleotide-binding protein 1B", "tax_id": 9913, "disease": "", "pathway": " (bta:281790); (R-BTA-170670); (R-BTA-392170); (R-BTA-400042); (R-BTA-418594); (R-BTA-9009391)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "2419165;3094012", "class_list": "", "function": "Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity of ADCY1, ADCY5 and ADCY6, leading to decreased intracellular cAMP levels (By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (By similarity). Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P04898;P11015;P31871;Q2KJC0", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0031821 G protein-coupled serotonin receptor binding;GO:0000287 magnesium ion binding;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0001664 G protein-coupled receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0051301 cell division;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:1904322 cellular response to forskolin;GO:1904778 positive regulation of protein localization to cell cortex", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P63097-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P63292-1", "uniprot_id": [ { "id": "SLIB_BOVIN", "url": "https://www.uniprot.org/uniprot/P63292", "type": "external" } ], "mass": 12058.0, "length": 106, "protein_name": "Somatoliberin", "gene_name": "GHRH", "organism": "Bovine", "refseq_name": "somatoliberin precursor", "refseq_ac": [ { "id": "NP_847895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_847895", "type": "external" } ], "gene_names_uniprotkb": "GHRH", "gene_names_refseq": "GHRH", "protein_names_uniprotkb": "Somatoliberin; GHRH; GRF; Growth hormone-releasing factor; Growth hormone-releasing hormone", "protein_names_refseq": "GRF; growth hormone-releasing factor; somatoliberin precursor; somatoliberin", "tax_id": 9913, "disease": "", "pathway": " (bta:281191); (R-BTA-418555); (R-BTA-420092)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "16749938;19632078;21353268;6421287", "class_list": "", "function": "Concentrations of GHRH in CSF were weakly correlated with serum concentrations of growth hormone (GH); 58% of the GH pulses were preceded by a pulse of GHRH and 90% of the GHRH pulses occurred within 20 min preceding a pulse of GH., [RefSeq, PubMed]; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone., [UniProtKB]; Polymorphism and association with growth traits in native Chinese breeds, [RefSeq, PubMed]; Polymorphisms in GHRH might be one of the important genetic factors that influence carcass yield in beef cattle Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P01288;Q9MZD4", "ec_number_list": [], "go_molecular_function": "GO:0031770 growth hormone-releasing hormone receptor binding;GO:0005184 neuropeptide hormone activity;GO:0051428 peptide hormone receptor binding;GO:0016608 growth hormone-releasing hormone activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0043195 terminal bouton;GO:0043204 perikaryon", "go_biological_process": "GO:0032024 positive regulation of insulin secretion;GO:0045745 positive regulation of G protein-coupled receptor signaling pathway;GO:0071277 cellular response to calcium ion;GO:0032880 regulation of protein localization;GO:0060124 positive regulation of growth hormone secretion", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P63292-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P67827-1", "uniprot_id": [ { "id": "KC1A_BOVIN", "url": "https://www.uniprot.org/uniprot/P67827", "type": "external" } ], "mass": 37567.0, "length": 325, "protein_name": "Casein kinase I isoform alpha", "gene_name": "CSNK1A1", "organism": "Bovine", "refseq_name": "casein kinase I isoform alpha", "refseq_ac": [ { "id": "NP_777136", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777136", "type": "external" } ], "gene_names_uniprotkb": "CSNK1A1", "gene_names_refseq": "CSNK1A1", "protein_names_uniprotkb": "Casein kinase I isoform alpha; 2.7.11.1; CK1; CKI-alpha", "protein_names_refseq": "CK1; CKI-alpha; casein kinase I isoform alpha; casein kinase I-alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:282684); (R-BTA-195253); (R-BTA-196299); (R-BTA-4641262); (R-BTA-5610785); (R-BTA-5635838); (R-BTA-69601)", "pathway_count": 7, "publication_count": 2, "publication_id_list": "15747732;1946367", "class_list": "", "function": "Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45' (By similarity). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (By similarity). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Sensitivy of a biosensor to detect alphas1-CN concentrations ranging from 8.8 to 12.06 mg/ml., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P35506;Q9GLY1;Q9GLY2;Q9GLY3", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.15", "type": "external" }, { "id": "2.7.11.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.16", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0051301 cell division;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P67827-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68102-1", "uniprot_id": [ { "id": "IF2A_BOVIN", "url": "https://www.uniprot.org/uniprot/P68102", "type": "external" } ], "mass": 36108.0, "length": 315, "protein_name": "Eukaryotic translation initiation factor 2 subunit 1", "gene_name": "EIF2S1", "organism": "Bovine", "refseq_name": "eukaryotic translation initiation factor 2 subunit 1", "refseq_ac": [ { "id": "NP_787007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_787007", "type": "external" } ], "gene_names_uniprotkb": "EIF2S1; EIF2A", "gene_names_refseq": "EIF2S1", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha; eIF2-alpha", "protein_names_refseq": "EIF-2A; EIF-2alpha; eIF-2-alpha; eIF2-alpha; eukaryotic translation initiation factor 2 subunit 1; eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:327694); (R-BTA-156827); (R-BTA-381042); (R-BTA-382556); (R-BTA-72649); (R-BTA-72695); (R-BTA-72702); (R-BTA-72731); (R-BTA-9840373)", "pathway_count": 9, "publication_count": 2, "publication_id_list": "1932125;20097734", "class_list": "", "function": "Caspase(s)-dependent proteolysis of molecular chaperones and eIF2alpha may be novel signaling pathways of apoptosis., [RefSeq, PubMed]; Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B. EIF2S1/eIF2-alpha is a key component of the integrated stress response (ISR), required for adaptation to various stress: phosphorylation by metabolic-stress sensing protein kinases (EIF2AK1/HRI, EIF2AK2/PKR, EIF2AK3/PERK and EIF2AK4/GCN2) in response to stress converts EIF2S1/eIF2-alpha in a global protein synthesis inhibitor, leading to a attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming. EIF2S1/eIF2-alpha also acts as an activator of mitophagy in response to mitochondrial damage: phosphorylation by EIF2AK1/HRI promotes relocalization to the mitochondrial surface, thereby triggering PRKN-independent mitophagy (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P05199;Q3SWZ1", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding;GO:0003743 translation initiation factor activity;GO:0160296 cap-dependent translation initiation factor activity;GO:0160297 IRES-mediated translation initiation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0045202 synapse", "go_biological_process": "GO:0006413 translational initiation;GO:0034599 cellular response to oxidative stress;GO:0006412 translation;GO:0036499 PERK-mediated unfolded protein response;GO:0000423 mitophagy", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P68102-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68103-1", "uniprot_id": [ { "id": "EF1A1_BOVIN", "url": "https://www.uniprot.org/uniprot/P68103", "type": "external" } ], "mass": 50141.0, "length": 462, "protein_name": "Elongation factor 1-alpha 1", "gene_name": "EEF1A1", "organism": "Bovine", "refseq_name": "elongation factor 1-alpha 1", "refseq_ac": [ { "id": "NP_776960", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776960", "type": "external" } ], "gene_names_uniprotkb": "EEF1A1; EEF1A; EF1A", "gene_names_refseq": "EEF1A1; EF-1-alpha-1; EF-Tu; eEF1A-1", "protein_names_uniprotkb": "Elongation factor 1-alpha 1; 3.6.5.-; EF-1-alpha-1; EF-Tu; Elongation factor Tu; Eukaryotic elongation factor 1 A-1; eEF1A-1", "protein_names_refseq": "elongation factor 1-alpha 1; elongation factor Tu; eukaryotic elongation factor 1 A-1", "tax_id": 9913, "disease": "", "pathway": " (bta:282220); (R-BTA-156842); (R-BTA-3371511); (R-BTA-6798695); (R-BTA-8876725)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "30573663;41018975", "class_list": "", "function": "Translation elongation factor that catalyzes the GTP-dependent binding of aminoacyl-tRNA (aa-tRNA) to the A-site of ribosomes during the elongation phase of protein synthesis. Base pairing between the mRNA codon and the aa-tRNA anticodon promotes GTP hydrolysis, releasing the aa-tRNA from EEF1A1 and allowing its accommodation into the ribosome. The growing protein chain is subsequently transferred from the P-site peptidyl tRNA to the A-site aa-tRNA, extending it by one amino acid through ribosome-catalyzed peptide bond formation. Also plays a role in the positive regulation of IFNG transcription in T-helper 1 cells as part of an IFNG promoter-binding complex with TXK and PARP1 (By similarity). Also plays a role in cytoskeleton organization by promoting actin bundling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PK01;P04719;P04720;Q2KJJ3", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0019209 kinase activator activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003746 translation elongation factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006412 translation;GO:0071364 cellular response to epidermal growth factor stimulus;GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P68103-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P68509-1", "uniprot_id": [ { "id": "1433F_BOVIN", "url": "https://www.uniprot.org/uniprot/P68509", "type": "external" } ], "mass": 28212.0, "length": 246, "protein_name": "14-3-3 protein eta", "gene_name": "YWHAH", "organism": "Bovine", "refseq_name": "14-3-3 protein eta", "refseq_ac": [ { "id": "NP_776917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776917", "type": "external" } ], "gene_names_uniprotkb": "YWHAH", "gene_names_refseq": "YWHAH", "protein_names_uniprotkb": "14-3-3 protein eta; KCIP-1; Protein kinase C inhibitor protein 1", "protein_names_refseq": "14-3-3 protein eta; KCIP-1; protein kinase C inhibitor protein 1; tyrosine 3-monooxygenase/tryotophan 5-monooxygenase activation protein; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide", "tax_id": 9913, "disease": "", "pathway": " (bta:282126); (R-BTA-111447); (R-BTA-5625740); (R-BTA-5628897); (R-BTA-75035)", "pathway_count": 5, "publication_count": 3, "publication_id_list": "1970123;2902623;7931346", "class_list": "", "function": "Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1 (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P11576;P70198;Q3ZC14", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0098793 presynapse;GO:0150048 cerebellar granule cell to Purkinje cell synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0006713 glucocorticoid catabolic process;GO:0042921 nuclear receptor-mediated glucocorticoid signaling pathway;GO:0086010 membrane depolarization during action potential;GO:0002028 regulation of sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P68509-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79098-1", "uniprot_id": [ { "id": "AMPN_BOVIN", "url": "https://www.uniprot.org/uniprot/P79098", "type": "external" } ], "mass": 109276.0, "length": 965, "protein_name": "Aminopeptidase N", "gene_name": "ANPEP", "organism": "Bovine", "refseq_name": "aminopeptidase N", "refseq_ac": [ { "id": "NP_001068612", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068612", "type": "external" } ], "gene_names_uniprotkb": "ANPEP; APN", "gene_names_refseq": "ANPEP; APN; CD13; P150", "protein_names_uniprotkb": "Aminopeptidase N; 3.4.11.2; AP-M; AP-N; Alanyl aminopeptidase; Aminopeptidase M; Microsomal aminopeptidase; bAPN", "protein_names_refseq": "AP-M; AP-N; alanyl (membrane) aminopeptidase; aminopeptidase M; aminopeptidase N; bAPN; microsomal aminopeptidase", "tax_id": 9913, "disease": "", "pathway": " (bta:404191)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "11985792;8985407", "class_list": "", "function": "APN activity is not responsible for betulinic acid-inhibited growth factor-induced angiogenesis in endothelial cells, [RefSeq, PubMed]; Broad specificity aminopeptidase which plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Also involved in the processing of various peptides including peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. May also be involved the cleavage of peptides bound to major histocompatibility complex class II molecules of antigen presenting cells. May have a role in angiogenesis and promote cholesterol crystallization. May have a role in amino acid transport by acting as binding partner of amino acid transporter SLC6A19 and regulating its activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3MHR1", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001618 virus receptor activity;GO:0070006 metalloaminopeptidase activity;GO:0016285 alanyl aminopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0002003 angiotensin maturation;GO:0043171 peptide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P79098-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79105-1", "uniprot_id": [ { "id": "S10AC_BOVIN", "url": "https://www.uniprot.org/uniprot/P79105", "type": "external" } ], "mass": 10685.0, "length": 92, "protein_name": "Protein S100-A12", "gene_name": "S100A12", "organism": "Bovine", "refseq_name": "protein S100-A12", "refseq_ac": [ { "id": "NP_777076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777076", "type": "external" } ], "gene_names_uniprotkb": "S100A12; CAAF1", "gene_names_refseq": "CAAF1; CAGC; CO-AG; EN-RAGE; S100A12", "protein_names_uniprotkb": "Protein S100-A12; CAAF1; CAGC; CO-AG; Calcium-binding protein in amniotic fluid 1; Calgranulin-C; Cornea-associated antigen; EN-RAGE; Extracellular newly identified RAGE-binding protein; RAGE-binding protein; S100 calcium-binding protein A12", "protein_names_refseq": "RAGE-binding protein; calcium-binding protein in amniotic fluid 1; calgranulin-C; cornea-associated antigen; extracellular newly identified RAGE-binding protein; protein S100-A12", "tax_id": 9913, "disease": "", "pathway": " (bta:282467); (R-BTA-445989); (R-BTA-6798695); (R-BTA-879415); (R-BTA-933542)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "10399917;30063108;8603881;8718672", "class_list": "", "function": "S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites (By similarity)., [UniProtKB]; The S100A12 level in milk may serve as a diagnostic tool for subclinical mastitis in cows without obvious clinical signs., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T070;Q9TR16", "ec_number_list": [], "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0048306 calcium-dependent protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043542 endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P79105-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79110-1", "uniprot_id": [ { "id": "TXTP_BOVIN", "url": "https://www.uniprot.org/uniprot/P79110", "type": "external" } ], "mass": 33876.0, "length": 311, "protein_name": "Tricarboxylate transport protein, mitochondrial", "gene_name": "SLC25A1", "organism": "Bovine", "refseq_name": "tricarboxylate transport protein, mitochondrial precursor", "refseq_ac": [ { "id": "NP_777081", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777081", "type": "external" } ], "gene_names_uniprotkb": "SLC25A1; SLC20A3", "gene_names_refseq": "SLC25A1", "protein_names_uniprotkb": "Tricarboxylate transport protein, mitochondrial; CTP; Citrate transport protein; Solute carrier family 25 member 1; Tricarboxylate carrier protein", "protein_names_refseq": "CTP; citrate transport protein; citrate transporter), member 1; solute carrier family 25 (mitochondrial carrier; tricarboxylate carrier protein; tricarboxylate transport protein, mitochondrial precursor; tricarboxylate transport protein, mitochondrial", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 3, "publication_id_list": "2549027;2729553;8865808", "class_list": "", "function": "Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate (PubMed:2549027, PubMed:2729553). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0071913 citrate secondary active transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006843 mitochondrial citrate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P79110-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79132-1", "uniprot_id": [ { "id": "CAV1_BOVIN", "url": "https://www.uniprot.org/uniprot/P79132", "type": "external" } ], "mass": 20595.0, "length": 178, "protein_name": "Caveolin-1", "gene_name": "CAV1", "organism": "Bovine", "refseq_name": "caveolin-1", "refseq_ac": [ { "id": "NP_776429", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776429", "type": "external" } ], "gene_names_uniprotkb": "CAV1", "gene_names_refseq": "CAV1", "protein_names_uniprotkb": "Caveolin-1", "protein_names_refseq": "caveolin 1, caveolae protein, 22kDa; caveolin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:281040); (R-BTA-203615); (R-BTA-203641); (R-BTA-209968); (R-BTA-4641262); (R-BTA-5218920); (R-BTA-8980692); (R-BTA-9009391); (R-BTA-9013106); (R-BTA-9013148); (R-BTA-9013404); (R-BTA-9013406); (R-BTA-9013407); (R-BTA-9013408); (R-BTA-9013423); (R-BTA-9035034); (R-BTA-9696264); (R-BTA-9696270); (R-BTA-9696273)", "pathway_count": 19, "publication_count": 8, "publication_id_list": "12917688;15292187;15471980;15637154;21724868;24648521;25419974;26409042", "class_list": "", "function": "Caveolin-1 is not required for the targeting of signaling molecules to caveolae/lipid rafts, [RefSeq, PubMed]; Caveolin-1 scaffolding domain residue phenylalanine 92 modulates Akt signaling, [RefSeq, PubMed]; Data show that resveratrol (Res) reversed caveolin-1 (Cav-1)/endothelial nitric oxide synthase (eNOS) expressions in high glucose cultured bovine aortic endothelial cells (BAECs). Publication Status: Online-Only, [RefSeq, PubMed]; Importance of CAV1 amino acids 89-95 and particularly F92 in mediating eNOS inhibition by AP-Cav and Cav-1, [RefSeq, PubMed]; Integrin activation with shear stress results in SFK-regulated caveolin-1 phosphorylation that, in turn, mediates Csk association at integrin sites, where it plays a role in downstream, shear-stimulated myelin light chain diphosphorylation., [RefSeq, PubMed]; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner (By similarity). Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway (By similarity). Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (By similarity). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Study identifies a critical role of caveolin-1 in the regulation of eNOS uncoupling via a biopterin-dependent mechanism., [RefSeq, PubMed]; These data provide the first detailed analysis of Cav-1 binding to one of its most significant client proteins, eNOS., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4D7R5;Q5PX19", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0008142 oxysterol binding;GO:0019901 protein kinase binding;GO:0051117 ATPase binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0045121 membrane raft", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0031623 receptor internalization;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0031295 T cell costimulation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "P79132-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80457-1", "uniprot_id": [ { "id": "XDH_BOVIN", "url": "https://www.uniprot.org/uniprot/P80457", "type": "external" } ], "mass": 146790.0, "length": 1332, "protein_name": "Xanthine dehydrogenase/oxidase", "gene_name": "XDH", "organism": "Bovine", "refseq_name": "xanthine dehydrogenase/oxidase", "refseq_ac": [ { "id": "NP_776397", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776397", "type": "external" } ], "gene_names_uniprotkb": "XDH", "gene_names_refseq": "XDH; XOR", "protein_names_uniprotkb": "Xanthine dehydrogenase/oxidase; XOR; Xanthine oxidoreductase", "protein_names_refseq": "xanthine dehydrogenase/oxidase; xanthine oxidoreductase", "tax_id": 9913, "disease": "", "pathway": " (bta:280960)", "pathway_count": 1, "publication_count": 14, "publication_id_list": "11005854;12421831;12817083;15148401;19109252;20615869;21077683;21356584;25243829;30059711;4352904;7556219;8708081;9388547", "class_list": "", "function": "6,8-dihydroxypurine is effectively converted to uric acid by xanthine oxidase., [RefSeq, PubMed]; Crystal structures of the urate complexes of the demolybdo-form of the D428A mutant of rat xanthine oxidoreductase and of the reduced bovine milk enzyme [XOR], [RefSeq, PubMed]; Data suggest that XDH (xanthine dehydrogenase) can be an important redox-regulated source of superoxide generation in ischemic tissue; conversion XDH to XO (xanthine oxidase) is not required to activate radical formation and subsequent tissue injury., [RefSeq, PubMed]; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species., [UniProtKB, UniProtKB]; Phe-549, Arg-335, Trp-336, & Arg-427 form the core of a relay system for the XDH/XO transition.They gate a solvent channel leading toward the FAD ring., [RefSeq, PubMed]; Plasma tumor necrosis factor-alpha response to either of two lipopolysaccharide challenges was lower in progesterone-treated than in 17beta-estradiol-treated steers. Xanthine oxidase response to either challenge was greater for estradiol-treated steers., [RefSeq, PubMed]; S-allyl cysteine as potent anti-gout drug: Insight into the xanthine oxidase inhibition and anti-inflammatory activity., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 3, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q95325", "ec_number_list": [ { "id": "1.17.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.1.4", "type": "external" }, { "id": "1.17.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.17.3.2", "type": "external" } ], "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0005506 iron ion binding;GO:0042803 protein homodimerization activity;GO:0050660 flavin adenine dinucleotide binding;GO:0071949 FAD binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005777 peroxisome;GO:0002197 xanthine dehydrogenase complex", "go_biological_process": "GO:0009115 xanthine catabolic process", "synthesized_glycan_count": 0, "hit_score": 1.5, "record_id": "P80457-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9S896-1", "uniprot_id": [ { "id": "A0AAA9S896_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9S896", "type": "external" } ], "mass": 115749.0, "length": 1044, "protein_name": "Lon protease homolog, mitochondrial", "gene_name": "LONP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LONP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Lon protease homolog, mitochondrial; 3.4.21.53; LONP; Lon protease-like protein; Mitochondrial ATP-dependent protease Lon; Serine protease 15", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9837999)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.7.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.23", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "6.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "1.1.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62", "type": "external" }, { "id": "1.1.1.239", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239", "type": "external" }, { "id": "1.1.1.178", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.159", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "2.3.3.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.10", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.3.8.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0043565 sequence-specific DNA binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0034599 cellular response to oxidative stress;GO:0007005 mitochondrion organization;GO:0006515 protein quality control for misfolded or incompletely synthesized proteins;GO:0051131 chaperone-mediated protein complex assembly;GO:0070407 oxidation-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9S896-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9TD06-1", "uniprot_id": [ { "id": "A0AAA9TD06_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9TD06", "type": "external" } ], "mass": 250843.0, "length": 2240, "protein_name": "Sortilin-related receptor", "gene_name": "SORL1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SORL1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sortilin-related receptor; Low-density lipoprotein receptor relative with 11 ligand-binding repeats; Sorting protein-related receptor containing LDLR class A repeats", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:533166)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0001540 amyloid-beta binding;GO:0031267 small GTPase binding;GO:0030169 low-density lipoprotein particle binding;GO:0019828 aspartic-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0006897 endocytosis;GO:0001960 negative regulation of cytokine-mediated signaling pathway;GO:1902966 positive regulation of protein localization to early endosome;GO:1904179 positive regulation of adipose tissue development;GO:0045053 protein retention in Golgi apparatus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9TD06-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27971-1", "uniprot_id": [ { "id": "CAN2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27971", "type": "external" } ], "mass": 79935.0, "length": 700, "protein_name": "Calpain-2 catalytic subunit", "gene_name": "CAPN2", "organism": "Bovine", "refseq_name": "calpain-2 catalytic subunit", "refseq_ac": [ { "id": "NP_001096556", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096556", "type": "external" } ], "gene_names_uniprotkb": "CAPN2", "gene_names_refseq": "CAPN2", "protein_names_uniprotkb": "Calpain-2 catalytic subunit; 3.4.22.53; CANP 2; Calcium-activated neutral proteinase 2; Calpain M-type; Calpain-2 large subunit; M-calpain; Millimolar-calpain", "protein_names_refseq": "CANP 2; M-calpain; calcium-activated neutral proteinase 2; calpain 2, (m/II) large subunit; calpain M-type; calpain, large polypeptide L2; calpain-2 catalytic subunit; calpain-2 large subunit; millimolar-calpain", "tax_id": 9913, "disease": "", "pathway": " (bta:281662); (R-BTA-1474228); (R-BTA-9856530); (R-BTA-9860927)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "20123702;20372982;20857204;23549461", "class_list": "", "function": "Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Characteristic properties of ER membrane m-calpain (MCp), calpastatins and lumen m-calpain (LCp) and a brief comparative study between MCp and LCp, [RefSeq, PubMed]; M- and micro-calpain immunosignals in the cytoplasm both along the Z disk/I band regions and in the form of intracellular stores. Publication Status: Online-Only, [RefSeq, PubMed]; The cleavage of NCX1 by m-calpain in the caveolae vesicles may be interpreted as an important mechanism of Ca(2+) overload, [RefSeq, PubMed]; The objective of this study was to estimate the allele and genotype frequencies of the IGF-IR/TaqI, m-calpain/HhaI, and UCP-3/BglI polymorphisms and to determine association between these polymorphisms and growth traits in Chinese indigenous cattle breed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4IFD3", "ec_number_list": [ { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0005634 nucleus;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006508 proteolysis;GO:0071230 cellular response to amino acid stimulus;GO:0051603 proteolysis involved in protein catabolic process;GO:0048488 synaptic vesicle endocytosis;GO:0140249 protein catabolic process at postsynapse", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q27971-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JQC6-1", "uniprot_id": [ { "id": "SIR4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JQC6", "type": "external" } ], "mass": 35588.0, "length": 315, "protein_name": "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial", "gene_name": "SIRT4", "organism": "Bovine", "refseq_name": "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial", "refseq_ac": [ { "id": "NP_001069253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069253", "type": "external" } ], "gene_names_uniprotkb": "SIRT4", "gene_names_refseq": "SIRT4", "protein_names_uniprotkb": "NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; 2.3.1.-; 2.3.1.286; 2.4.2.-; NAD-dependent ADP-ribosyltransferase sirtuin-4; NAD-dependent protein biotinylase sirtuin-4; NAD-dependent protein deacetylase sirtuin-4; Regulatory protein SIR2 homolog 4; SIR2-like protein 4", "protein_names_refseq": "NAD-dependent deacetylase sirtuin-4; NAD-dependent protein biotinylase sirtuin-4; NAD-dependent protein lipoamidase sirtuin-4, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:519328); (R-BTA-204174); (R-BTA-2151201)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "30442871;30570339;30689508;30963403", "class_list": "", "function": "Acts as NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion., [UniProtKB, HAMAP, UniProtKB, UniProtKB]; Acts as a NAD-dependent protein lipoamidase, biotinylase, deacetylase and ADP-ribosyl transferase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys-471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Does not seem to deacetylate PC. Controls fatty acid oxidation by inhibiting PPARA transcriptional activation. Impairs SIRT1-PPARA interaction probably through the regulation of NAD(+) levels. Down-regulates insulin secretion (By similarity)., [UniProtKB, HAMAP]; NRF1-mediated transcriptional inhibition and CMYB-mediated transcriptional activation of SIRT4 expression were strengthened by demethylation during bovine adipocyte differentiation, [RefSeq, PubMed]; The relationship analyses indicated that this indel was significantly associated with growth traits (p < 0.05), implying that SIRT4 significantly affects the growth traits., [RefSeq, PubMed]; This study evaluated the association of four single nucleotide polymorphisms with subcutaneous fat depth and intramuscular fat content in Qinchuan cattle., [RefSeq, PubMed]; Transcription factors and SIRT4 gene cooperatively regulated the relative expression of adipocyte differentiation marker genes. The core promoter of bovine SIRT4 was identified in the -402/-60 bp region of the cloned 2-kb fragment containing the 5'-regulatory region. Binding sites were identified in this region for E2F transcription factor-1 (E2F1), CCAAT/enhancer-binding protein beta (CEBPbeta), homeobox A5 (HOXA5). Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.1.3", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070403 NAD+ binding;GO:0004407 histone deacetylase activity;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0046322 negative regulation of fatty acid oxidation;GO:0046889 positive regulation of lipid biosynthetic process;GO:0006974 DNA damage response;GO:0046676 negative regulation of insulin secretion;GO:0006541 glutamine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q1JQC6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJE4-1", "uniprot_id": [ { "id": "UBP15_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJE4", "type": "external" } ], "mass": 109442.0, "length": 952, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 15", "gene_name": "USP15", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 15", "refseq_ac": [ { "id": "NP_001039895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039895", "type": "external" } ], "gene_names_uniprotkb": "USP15", "gene_names_refseq": "USP15", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 15; 3.4.19.12; Deubiquitinating enzyme 15; Ubiquitin thioesterase 15; Ubiquitin-specific-processing protease 15", "protein_names_refseq": "deubiquitinating enzyme 15; ubiquitin carboxyl-terminal hydrolase 15; ubiquitin thioesterase 15; ubiquitin-specific-processing protease 15", "tax_id": 9913, "disease": "", "pathway": " (bta:538284); (R-BTA-5689880)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB]; Hydrolase that removes conjugated ubiquitin from target proteins and regulates various pathways such as the TGF-beta receptor signaling, NF-kappa-B and RNF41/NRDP1-PRKN pathways. Acts as a key regulator of TGF-beta receptor signaling pathway, but the precise mechanism is still unclear: according to a report, acts by promoting deubiquitination of monoubiquitinated R-SMADs (SMAD1, SMAD2 and/or SMAD3), thereby alleviating inhibition of R-SMADs and promoting activation of TGF-beta target genes. According to another reports, regulates the TGF-beta receptor signaling pathway by mediating deubiquitination and stabilization of TGFBR1, leading to an enhanced TGF-beta signal. Able to mediate deubiquitination of monoubiquitinated substrates, 'Lys-27'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May also regulate gene expression and/or DNA repair through the deubiquitination of histone H2B. Acts as an inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes cleavage of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains attached by parkin on target proteins such as MFN2, thereby reducing parkin's ability to drive mitophagy. Acts as an associated component of COP9 signalosome complex (CSN) and regulates different pathways via this association: regulates NF-kappa-B by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to VCP. Involved in endosome organization by mediating deubiquitination of SQSTM1: ubiquitinated SQSTM1 forms a molecular bridge that restrains cognate vesicles in the perinuclear region and its deubiquitination releases target vesicles for fast transport into the cell periphery. Acts as a negative regulator of antifungal immunity by mediating 'Lys-27'-linked deubiquitination of CARD9, thereby inactivating CARD9., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004197 cysteine-type endopeptidase activity;GO:0004843 cysteine-type deubiquitinase activity;GO:0061649 ubiquitin-modified histone reader activity;GO:0005160 transforming growth factor beta receptor binding;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:1905035 negative regulation of antifungal innate immune response;GO:0006508 proteolysis;GO:0030509 BMP signaling pathway;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0035520 monoubiquitinated protein deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2HJE4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIJ3-1", "uniprot_id": [ { "id": "WASF1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIJ3", "type": "external" } ], "mass": 61640.0, "length": 559, "protein_name": "Actin-binding protein WASF1", "gene_name": "WASF1", "organism": "Bovine", "refseq_name": "actin-binding protein WASF1", "refseq_ac": [ { "id": "NP_001029189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029189", "type": "external" } ], "gene_names_uniprotkb": "WASF1", "gene_names_refseq": "WASF1; WAVE1", "protein_names_uniprotkb": "Actin-binding protein WASF1; Protein WAVE-1; WASP family protein member 1; Wiskott-Aldrich syndrome protein family member 1", "protein_names_refseq": "WAS protein family member 1; WASP family protein member 1; Wiskott-Aldrich syndrome protein family member 1; actin-binding protein WASF1; protein WAVE-1; verprolin homology domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:531488); (R-BTA-2029482); (R-BTA-5663213); (R-BTA-9013423)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "12181570;15581863", "class_list": "", "function": "Data show that WAVE1 sequestration to the nucleus is required during fertilization, and is an actin-independent event that relies on dynamic microtubules but not nuclear pores., [RefSeq, PubMed]; Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). Also involved in the regulation of mitochondrial dynamics (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0071933 Arp2/3 complex binding;GO:0031267 small GTPase binding;GO:0051018 protein kinase A binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005925 focal adhesion;GO:0005938 cell cortex", "go_biological_process": "GO:1990416 cellular response to brain-derived neurotrophic factor stimulus;GO:0030036 actin cytoskeleton organization;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0006898 receptor-mediated endocytosis;GO:0072673 lamellipodium morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0IIJ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DA3-1", "uniprot_id": [ { "id": "UBP16_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DA3", "type": "external" } ], "mass": 94050.0, "length": 826, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 16", "gene_name": "USP16", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 16", "refseq_ac": [ { "id": "NP_001070335", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070335", "type": "external" } ], "gene_names_uniprotkb": "USP16", "gene_names_refseq": "USP16", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 16; 3.4.19.12; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16", "protein_names_refseq": "deubiquitinating enzyme 16; ubiquitin carboxyl-terminal hydrolase 16; ubiquitin thioesterase 16; ubiquitin thiolesterase 16; ubiquitin-specific-processing protease 16", "tax_id": 9913, "disease": "", "pathway": " (bta:519992)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19393038;32646283", "class_list": "", "function": "Copy number variation of the USP16 gene and its association with milk traits in Chinese Holstein cattle., [RefSeq, PubMed]; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B. Also deubiquitinates non-histone proteins, such as ribosomal protein RPS27A: deubiquitination of monoubiquitinated RPS27A promotes maturation of the 40S ribosomal subunit. Also mediates deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5), promoting their stability., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1N2B1", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0043024 ribosomal small subunit binding;GO:0042393 histone binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051289 protein homotetramerization", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08DA3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9S2J2-1", "uniprot_id": [ { "id": "A0AAA9S2J2_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9S2J2", "type": "external" } ], "mass": 97618.0, "length": 864, "protein_name": "Protein argonaute-2", "gene_name": "AGO2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AGO2; EIF2C2", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein argonaute-2; 3.1.26.n2; Argonaute2; Eukaryotic translation initiation factor 2C 2; Protein slicer; eIF-2C 2; eIF2C 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0035198 miRNA binding;GO:0000340 RNA 7-methylguanosine cap binding;GO:0035197 siRNA binding;GO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA", "go_cellular_component": "GO:0005634 nucleus;GO:0000932 P-body;GO:0016442 RISC complex;GO:0098978 glutamatergic synapse;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0045947 negative regulation of translational initiation;GO:0031054 pre-miRNA processing;GO:0035278 miRNA-mediated gene silencing by inhibition of translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9S2J2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27966-1", "uniprot_id": [ { "id": "MYO1C_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27966", "type": "external" } ], "mass": 121936.0, "length": 1063, "protein_name": "Unconventional myosin-Ic", "gene_name": "MYO1C", "organism": "Bovine", "refseq_name": "unconventional myosin-Ic", "refseq_ac": [ { "id": "NP_776821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776821", "type": "external" } ], "gene_names_uniprotkb": "MYO1C", "gene_names_refseq": "MMIb; MYO1C", "protein_names_uniprotkb": "Unconventional myosin-Ic; MMI-beta; MMIb; Myosin I beta", "protein_names_refseq": "MMI-beta; myosin I beta; myosin-Ic; unconventional myosin-Ic", "tax_id": 9913, "disease": "", "pathway": " (bta:281937); (R-BTA-5250924)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "22778278;8022785;8313976", "class_list": "", "function": "Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation., [UniProtKB, UniProtKB]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity)., [UniProtKB, UniProtKB]; Vectorial transport of G-actin was shown in live migrating endothelial cells. Myo1c (an unconventional F-actin-binding motor protein) was identified as a major G-actin-interacting protein. The cargo-binding tail domain of Myo1c interacted with G-actin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A5D7F3;Q28138", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003779 actin binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030048 actin filament-based movement;GO:0030335 positive regulation of cell migration;GO:0006612 protein targeting to membrane", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q27966-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E38-1", "uniprot_id": [ { "id": "PRP19_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E38", "type": "external" } ], "mass": 55195.0, "length": 504, "protein_name": "Pre-mRNA-processing factor 19", "gene_name": "PRPF19", "organism": "Bovine", "refseq_name": "pre-mRNA-processing factor 19", "refseq_ac": [ { "id": "NP_001069108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069108", "type": "external" } ], "gene_names_uniprotkb": "PRPF19", "gene_names_refseq": "PRPF19", "protein_names_uniprotkb": "Pre-mRNA-processing factor 19; 2.3.2.27; PRP19/PSO4 homolog; RING-type E3 ubiquitin transferase PRP19", "protein_names_refseq": "PRP19/PSO4 homolog; PRP19/PSO4 pre-mRNA processing factor 19 homolog; RING-type E3 ubiquitin transferase PRP19; pre-mRNA-processing factor 19", "tax_id": 9913, "disease": "", "pathway": " (bta:513868); (R-BTA-6781823); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-72163)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex. Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries. The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair. Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response. May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA. As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process. In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (By similarity). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0061630 ubiquitin protein ligase activity;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005819 spindle;GO:0016607 nuclear speck", "go_biological_process": "GO:0000244 spliceosomal tri-snRNP complex assembly;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0008104 intracellular protein localization;GO:0010498 proteasomal protein catabolic process;GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E38-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ53-1", "uniprot_id": [ { "id": "IMPA3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ53", "type": "external" } ], "mass": 38924.0, "length": 362, "protein_name": "Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase", "gene_name": "BPNT2", "organism": "Bovine", "refseq_name": "Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase", "refseq_ac": [ { "id": "NP_001039800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039800", "type": "external" } ], "gene_names_uniprotkb": "BPNT2; IMPA3; IMPAD1", "gene_names_refseq": "BPNT2; IMPAD1; gPAPP", "protein_names_uniprotkb": "Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; 3'(2'), 5'-bisphosphate nucleotidase 2; 3.1.3.7; Golgi-resident PAP phosphatase; Inositol monophosphatase domain-containing protein 1; Myo-inositol monophosphatase A3; Phosphoadenosine phosphate 3'-nucleotidase; gPAPP", "protein_names_refseq": "Golgi-resident PAP phosphatase; Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase; IMP 3; IMPase 3; inositol monophosphatase 3; inositol monophosphatase domain containing 1; inositol monophosphatase domain-containing protein 1; inositol-1(or 4)-monophosphatase 3; myo-inositol monophosphatase A3; phosphoadenosine phosphate 3'-nucleotidase", "tax_id": 9913, "disease": "", "pathway": " (bta:532797); (R-BTA-156584)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.57", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.57", "type": "external" }, { "id": "3.1.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.7", "type": "external" } ], "go_molecular_function": "GO:0008254 3'-nucleotidase activity;GO:0097657 3',5'-nucleotide bisphosphate phosphatase activity;GO:0046872 metal ion binding;GO:0008441 3'(2'),5'-bisphosphate nucleotidase activity", "go_cellular_component": "GO:0032588 trans-Golgi network membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0001501 skeletal system development;GO:0046854 phosphatidylinositol phosphate biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJ53-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIW9-1", "uniprot_id": [ { "id": "KCY_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIW9", "type": "external" } ], "mass": 22279.0, "length": 196, "protein_name": "UMP-CMP kinase", "gene_name": "CMPK1", "organism": "Bovine", "refseq_name": "UMP-CMP kinase", "refseq_ac": [ { "id": "NP_001039509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039509", "type": "external" } ], "gene_names_uniprotkb": "CMPK1; CMPK", "gene_names_refseq": "CK; CMPK1; CMPK", "protein_names_uniprotkb": "UMP-CMP kinase; 2.7.4.14; 2.7.4.6; CK; Deoxycytidylate kinase; Nucleoside-diphosphate kinase; UMP/CMP kinase; UMP/CMPK; Uridine monophosphate/cytidine monophosphate kinase; dCMP kinase", "protein_names_refseq": "UMP-CMP kinase; UMP/CMPK; cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; cytidine monophosphate kinase; cytidylate kinase; dCMP kinase; deoxycytidylate kinase; nucleoside-diphosphate kinase; uridine monophosphate kinase; uridine monophosphate/cytidine monophosphate kinase", "tax_id": 9913, "disease": "", "pathway": " (bta:509965); (R-BTA-499943)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity;GO:0033862 UMP kinase activity;GO:0036430 CMP kinase activity;GO:0036431 dCMP kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process;GO:0006225 UDP biosynthetic process;GO:0046705 CDP biosynthetic process;GO:0006221 pyrimidine nucleotide biosynthetic process;GO:0006139 nucleobase-containing compound metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIW9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJD9-1", "uniprot_id": [ { "id": "ELOV5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJD9", "type": "external" } ], "mass": 35377.0, "length": 299, "protein_name": "Very long chain fatty acid elongase 5", "gene_name": "ELOVL5", "organism": "Bovine", "refseq_name": "very long chain fatty acid elongase 5", "refseq_ac": [ { "id": "NP_001040062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040062", "type": "external" } ], "gene_names_uniprotkb": "ELOVL5", "gene_names_refseq": "ELOVL5", "protein_names_uniprotkb": "Very long chain fatty acid elongase 5; 2.3.1.199; 3-keto acyl-CoA synthase ELOVL5; ELOVL FA elongase 5; ELOVL fatty acid elongase 5; Elongation of very long chain fatty acids protein 5; Very long chain 3-ketoacyl-CoA synthase 5; Very long chain 3-oxoacyl-CoA synthase 5", "protein_names_refseq": "3-keto acyl-CoA synthase ELOVL5; ELOVL FA elongase 5; ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast); elongation of very long chain fatty acids protein 5; very long chain 3-ketoacyl-CoA synthase 5; very long chain 3-oxoacyl-CoA synthase 5; very long chain fatty acid elongase 5", "tax_id": 9913, "disease": "", "pathway": " (bta:617293); (R-BTA-2046105); (R-BTA-2046106); (R-BTA-75876)", "pathway_count": 4, "publication_count": 3, "publication_id_list": "23269620;30707627;33525659", "class_list": "", "function": "Bta-miR-21-3p promotes triglyceride production, which might be attributed to the expression of the target gene Elovl5, [RefSeq, PubMed]; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]; ELOVL5 Participates in Embryonic Lipid Determination of Cellular Membranes and Cytoplasmic Droplets. Publication Status: Online-Only, [RefSeq, PubMed]; We performed association analysis between the genotypes and traits and our result revealed that T allele of g.-110T>C in ELOVL5 gene promoter indicated significantly thinner subcutaneous fat thickness than that of C allele, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.199", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.199", "type": "external" } ], "go_molecular_function": "GO:0009922 fatty acid elongase activity", "go_cellular_component": "GO:0097447 dendritic tree;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0035338 long-chain fatty-acyl-CoA biosynthetic process;GO:0006636 unsaturated fatty acid biosynthetic process;GO:0034625 fatty acid elongation, monounsaturated fatty acid;GO:0034626 fatty acid elongation, polyunsaturated fatty acid", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2KJD9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9TXZ0-1", "uniprot_id": [ { "id": "A0AAA9TXZ0_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9TXZ0", "type": "external" } ], "mass": 139020.0, "length": 1229, "protein_name": "PAN2-PAN3 deadenylation complex catalytic subunit PAN2", "gene_name": "PAN2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PAN2", "gene_names_refseq": "", "protein_names_uniprotkb": "PAN2-PAN3 deadenylation complex catalytic subunit PAN2; 3.1.13.4; Inactive ubiquitin carboxyl-terminal hydrolase 52; PAB1P-dependent poly(A)-specific ribonuclease; PAN deadenylation complex subunit 2; Poly(A)-nuclease deadenylation complex subunit 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-429947)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. Also acts as an important regulator of the HIF1A-mediated hypoxic response. Required for HIF1A mRNA stability independent of poly(A) tail length regulation., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0046872 metal ion binding;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0000932 P-body;GO:0031251 PAN complex;GO:0005634 nucleus", "go_biological_process": "GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening;GO:0006397 mRNA processing;GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9TXZ0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9SZ98-1", "uniprot_id": [ { "id": "A0AAA9SZ98_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9SZ98", "type": "external" } ], "mass": 86511.0, "length": 777, "protein_name": "tRNA (cytosine(34)-C(5))-methyltransferase", "gene_name": "NSUN2", "organism": "Bovine", "refseq_name": "RNA cytosine C(5)-methyltransferase NSUN2 isoform X1", "refseq_ac": [ { "id": "XP_002696495", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696495", "type": "external" } ], "gene_names_uniprotkb": "NSUN2", "gene_names_refseq": "NSUN2", "protein_names_uniprotkb": "tRNA (cytosine(34)-C(5))-methyltransferase; 2.1.1.203; NOL1/NOP2/Sun domain family member 2; mRNA cytosine C(5)-methyltransferase; tRNA cytosine C(5)-methyltransferase", "protein_names_refseq": "RNA cytosine C(5)-methyltransferase NSUN2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:516044)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.203", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.203", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016428 tRNA (cytidine-5-)-methyltransferase activity;GO:0000049 tRNA binding;GO:0062152 mRNA (cytidine-5-)-methyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005730 nucleolus;GO:0005739 mitochondrion", "go_biological_process": "GO:0030488 tRNA methylation;GO:0033313 meiotic cell cycle checkpoint signaling;GO:0006397 mRNA processing;GO:0007286 spermatid development;GO:0010793 regulation of mRNA export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9SZ98-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9RUG7-1", "uniprot_id": [ { "id": "A0AAA9RUG7_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9RUG7", "type": "external" } ], "mass": 82518.0, "length": 733, "protein_name": "Solute carrier family 15 member 2", "gene_name": "SLC15A2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC15A2", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 15 member 2; Kidney H(+)/peptide cotransporter; Oligopeptide transporter, kidney isoform; Peptide transporter 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1. In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate. Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs. Transports the dipeptide-like aminopeptidase inhibitor bestatin. Also able to transport carnosine. Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0071916 dipeptide transmembrane transporter activity;GO:0035673 oligopeptide transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0030670 phagocytic vesicle membrane;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0140206 dipeptide import across plasma membrane;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9RUG7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJI7-1", "uniprot_id": [ { "id": "AFG32_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJI7", "type": "external" } ], "mass": 89388.0, "length": 805, "protein_name": "Mitochondrial inner membrane m-AAA protease component AFG3L2", "gene_name": "AFG3L2", "organism": "Bovine", "refseq_name": "mitochondrial inner membrane m-AAA protease component AFG3L2", "refseq_ac": [ { "id": "NP_001039676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039676", "type": "external" } ], "gene_names_uniprotkb": "AFG3L2", "gene_names_refseq": "AFG3L2", "protein_names_uniprotkb": "Mitochondrial inner membrane m-AAA protease component AFG3L2; 3.4.24.-; 3.6.-.-; AFG3-like protein 2", "protein_names_refseq": "AFG3 ATPase family gene 3-like 2; AFG3-like protein 2 (Paraplegin-like protein); mitochondrial inner membrane m-AAA protease component AFG3L2", "tax_id": 9913, "disease": "", "pathway": " (bta:515757); (R-BTA-8949664); (R-BTA-9837999)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic component of the m-AAA protease, a protease that plays a key role in proteostasis of inner mitochondrial membrane proteins, and which is essential for axonal and neuron development. AFG3L2 possesses both ATPase and protease activities: the ATPase activity is required to unfold substrates, threading them into the internal proteolytic cavity for hydrolysis into small peptide fragments. The m-AAA protease carries out protein quality control in the inner membrane of the mitochondria by mediating degradation of mistranslated or misfolded polypeptides. The m-AAA protease complex also promotes the processing and maturation of mitochondrial proteins, such as MRPL32/bL32m, PINK1 and SP7. Mediates protein maturation of the mitochondrial ribosomal subunit MRPL32/bL32m by catalyzing the cleavage of the presequence of MRPL32/bL32m prior to assembly into the mitochondrial ribosome. Required for SPG7 maturation into its active mature form after SPG7 cleavage by mitochondrial-processing peptidase (MPP). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Acts as a regulator of calcium in neurons by mediating degradation of SMDT1/EMRE before its assembly with the uniporter complex, limiting the availability of SMDT1/EMRE for MCU assembly and promoting efficient assembly of gatekeeper subunits with MCU. Promotes the proteolytic degradation of GHITM upon hyperpolarization of mitochondria: progressive GHITM degradation leads to respiratory complex I degradation and broad reshaping of the mitochondrial proteome by AFG3L2. Also acts as a regulator of mitochondrial glutathione homeostasis by mediating cleavage and degradation of SLC25A39. SLC25A39 cleavage is prevented when SLC25A39 binds iron-sulfur. Also acts as a regulator of carnitine biosynthesis by mediating cleavage and degradation of SLC25A45. Involved in the regulation of OMA1-dependent processing of OPA1. May act by mediating processing of OMA1 precursor, participating in OMA1 maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.4.24.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.64", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "7.1.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.9", "type": "external" } ], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005745 m-AAA complex;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007409 axonogenesis;GO:0016485 protein processing;GO:0016540 protein autoprocessing;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJI7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QL5-1", "uniprot_id": [ { "id": "CC50A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QL5", "type": "external" } ], "mass": 40684.0, "length": 361, "protein_name": "Cell cycle control protein 50A", "gene_name": "TMEM30A", "organism": "Bovine", "refseq_name": "cell cycle control protein 50A", "refseq_ac": [ { "id": "NP_001068691", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068691", "type": "external" } ], "gene_names_uniprotkb": "TMEM30A", "gene_names_refseq": "TMEM30A", "protein_names_uniprotkb": "Cell cycle control protein 50A; P4-ATPase flippase complex beta subunit TMEM30A; Transmembrane protein 30A", "protein_names_refseq": "P4-ATPase flippase complex beta subunit TMEM30A; cell cycle control protein 50A", "tax_id": 9913, "disease": "", "pathway": " (bta:505797); (R-BTA-6798695)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "19393038;21454556;26592152;30573663", "class_list": "", "function": "Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. ATP8A2:TMEM30A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:TMEM30A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF). Can also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations., [UniProtKB, PubMed]; CDC50A is the beta-subunit of ATP8A2 and is crucial for the correct folding, stable expression, export from endoplasmic reticulum, and phosphatidylserine flippase activity of ATP8A2, [RefSeq, PubMed]; Mutations in mammalian P4-ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit, [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 5, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F1MNX5", "ec_number_list": [], "go_molecular_function": "GO:0015247 aminophospholipid flippase activity;GO:0005198 structural molecule activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0006869 lipid transport;GO:0010976 positive regulation of neuron projection development;GO:0036010 protein localization to endosome;GO:0006855 xenobiotic transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q17QL5-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ15-1", "uniprot_id": [ { "id": "PDGFA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ15", "type": "external" } ], "mass": 24009.0, "length": 211, "protein_name": "Platelet-derived growth factor subunit A", "gene_name": "PDGFA", "organism": "Bovine", "refseq_name": "platelet-derived growth factor subunit A precursor", "refseq_ac": [ { "id": "NP_001068699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068699", "type": "external" } ], "gene_names_uniprotkb": "PDGFA", "gene_names_refseq": "PDGFA", "protein_names_uniprotkb": "Platelet-derived growth factor subunit A; PDGF subunit A; Platelet-derived growth factor A chain; Platelet-derived growth factor alpha polypeptide", "protein_names_refseq": "PDGF subunit A; platelet-derived growth factor A chain; platelet-derived growth factor alpha polypeptide; platelet-derived growth factor subunit A precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:505908); (R-BTA-114608); (R-BTA-1257604); (R-BTA-186763); (R-BTA-186797); (R-BTA-5673001); (R-BTA-6811558)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005161 platelet-derived growth factor receptor binding;GO:0042803 protein homodimerization activity;GO:0005518 collagen binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0016020 membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0030335 positive regulation of cell migration;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJ15-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JQC1-1", "uniprot_id": [ { "id": "MFSD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JQC1", "type": "external" } ], "mass": 51538.0, "length": 468, "protein_name": "Lysosomal dipeptide transporter MFSD1", "gene_name": "MFSD1", "organism": "Bovine", "refseq_name": "lysosomal dipeptide transporter MFSD1", "refseq_ac": [ { "id": "NP_001068819", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068819", "type": "external" } ], "gene_names_uniprotkb": "MFSD1", "gene_names_refseq": "MFSD1", "protein_names_uniprotkb": "Lysosomal dipeptide transporter MFSD1; Major facilitator superfamily domain-containing protein 1", "protein_names_refseq": "lysosomal dipeptide transporter MFSD1; major facilitator superfamily domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:508337)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion (By similarity). Also essential for liver homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0160178 dipeptide uniporter activity;GO:0022857 transmembrane transporter activity", "go_cellular_component": "GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0050821 protein stabilization;GO:0061462 protein localization to lysosome;GO:0141204 dipeptide transmembrane transport from lysosomal lumen to cytosol", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1JQC1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81948-1", "uniprot_id": [ { "id": "TBA4A_BOVIN", "url": "https://www.uniprot.org/uniprot/P81948", "type": "external" } ], "mass": 49924.0, "length": 448, "protein_name": "Tubulin alpha-4A chain", "gene_name": "LOC100141266; TUBA4A", "organism": "Bovine", "refseq_name": "tubulin alpha-4A chain", "refseq_ac": [ { "id": "NP_001071626", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071626", "type": "external" } ], "gene_names_uniprotkb": "LOC100141266; TUBA4A; LOC100141266; TUBA1", "gene_names_refseq": "TUBA4A", "protein_names_uniprotkb": "Tubulin alpha-4A chain; 3.6.5.-; Alpha-tubulin 1; Tubulin alpha-1 chain", "protein_names_refseq": "alpha-tubulin 1; tubulin alpha-1 chain; tubulin alpha-4A chain; tubulin, alpha 1", "tax_id": 9913, "disease": "", "pathway": " (bta:100141266); (bta:777775); (R-BTA-114608); (R-BTA-2132295); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-2565942); (R-BTA-3371497); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-5620924); (R-BTA-6807878); (R-BTA-6811436); (R-BTA-8854518); (R-BTA-9646399); (R-BTA-9648025)", "pathway_count": 19, "publication_count": 5, "publication_id_list": "16305752;2207090;6504138;7704569;9571153", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q17QT1;Q5E986", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.15.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "5.3.99.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.124", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.124", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005929 cilium", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P81948-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27955-1", "uniprot_id": [ { "id": "KCAB2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27955", "type": "external" } ], "mass": 40985.0, "length": 367, "protein_name": "Voltage-gated potassium channel subunit beta-2", "gene_name": "KCNAB2", "organism": "Bovine", "refseq_name": "voltage-gated potassium channel subunit beta-2 isoform 1", "refseq_ac": [ { "id": "NP_001014405", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014405", "type": "external" } ], "gene_names_uniprotkb": "KCNAB2; KVB2", "gene_names_refseq": "KCNAB2", "protein_names_uniprotkb": "Voltage-gated potassium channel subunit beta-2; 1.1.1.-; K(+) channel subunit beta-2; Kv-beta-2", "protein_names_refseq": "K(+) channel subunit beta-2; kv-beta-2; potassium voltage-gated channel, shaker-related subfamily, beta member 2; voltage-gated potassium channel subunit beta-2 isoform 1; voltage-gated potassium channel subunit beta-2", "tax_id": 9913, "disease": "", "pathway": " (bta:541597); (R-BTA-1296072); (R-BTA-6798695)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11086297;30573663;8127858", "class_list": "", "function": "Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. The beta-2/KCNAB2 cytoplasmic subunit promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore. Promotes the inactivation of Kv1.4/KCNA4 and Kv1.5/KCNA5 alpha subunit-containing channels (By similarity). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a wide range of aldehyde and ketone substrates. Substrate specificity includes methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro, no physiological substrate identified yet). The binding of oxidized and reduced nucleotide alters Kv channel gating and may contribute to dynamic fine tuning of cell excitability (By similarity). Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58HC4", "ec_number_list": [ { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.184", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.184", "type": "external" }, { "id": "1.1.1.189", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.189", "type": "external" }, { "id": "1.1.1.197", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.197", "type": "external" }, { "id": "1.1.1.196", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.196", "type": "external" }, { "id": "1.1.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.71", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" }, { "id": "1.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.2", "type": "external" }, { "id": "1.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.-.-", "type": "external" }, { "id": "1.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.19", "type": "external" }, { "id": "1.1.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.20", "type": "external" }, { "id": "1.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.372", "type": "external" }, { "id": "1.1.1.54", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.54", "type": "external" }, { "id": "1.1.1.300", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.300", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0005249 voltage-gated potassium channel activity;GO:1990002 methylglyoxal reductase (NADPH) (acetol producing) activity", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0016020 membrane;GO:0030424 axon", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:2000008 regulation of protein localization to cell surface", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q27955-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCK0-1", "uniprot_id": [ { "id": "PUR9_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCK0", "type": "external" } ], "mass": 64483.0, "length": 592, "protein_name": "Bifunctional purine biosynthesis protein ATIC", "gene_name": "ATIC", "organism": "Bovine", "refseq_name": "bifunctional purine biosynthesis protein ATIC", "refseq_ac": [ { "id": "NP_001068722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068722", "type": "external" } ], "gene_names_uniprotkb": "ATIC; PURH", "gene_names_refseq": "ATIC", "protein_names_uniprotkb": "Bifunctional purine biosynthesis protein ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR formyltransferase; AICAR transformylase/inosine monophosphate cyclohydrolase; AICAR transformylase; ATIC; IMP synthase; Inosinicase", "protein_names_refseq": "AICAR transformylase/inosine monophosphate cyclohydrolase; bifunctional purine biosynthesis protein ATIC; bifunctional purine biosynthesis protein PURH", "tax_id": 9913, "disease": "", "pathway": " (bta:506343); (R-BTA-73817)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.3", "type": "external" }, { "id": "3.5.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.10", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003937 IMP cyclohydrolase activity;GO:0004643 phosphoribosylaminoimidazolecarboxamide formyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006177 GMP biosynthetic process;GO:0006189 'de novo' IMP biosynthetic process;GO:0044208 'de novo' AMP biosynthetic process;GO:0097294 'de novo' XMP biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCK0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28198-1", "uniprot_id": [ { "id": "TPA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28198", "type": "external" } ], "mass": 63701.0, "length": 566, "protein_name": "Tissue-type plasminogen activator", "gene_name": "PLAT", "organism": "Bovine", "refseq_name": "tissue-type plasminogen activator precursor", "refseq_ac": [ { "id": "NP_776571", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776571", "type": "external" } ], "gene_names_uniprotkb": "PLAT", "gene_names_refseq": "PLAT", "protein_names_uniprotkb": "Tissue-type plasminogen activator; 3.4.21.68; t-PA; t-plasminogen activator; tPA", "protein_names_refseq": "t-PA; t-plasminogen activator; tPA; tissue plasminogen activator; tissue-type plasminogen activator precursor; tissue-type plasminogen activator", "tax_id": 9913, "disease": "", "pathway": " (bta:281407); (R-BTA-186797); (R-BTA-75205)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "15128599;15207722;22177313;30939202", "class_list": "", "function": "Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy., [UniProtKB, UniProtKB]; Plasminogen activator, tissue type regulates germinal vesicle breakdown and cumulus expansion of bovine cumulus-oocyte complex in vitrodagger., [RefSeq, PubMed]; Stage-dependent regulation of granulosa cell PA and SerpinE2 production, consistent with a role in extracellular matrix remodeling during follicle growth, [RefSeq, PubMed]; The plasminogen/plasminogen activator/plasmin system is activated during gamete interaction and regulates the sperm entry into the oocyte., [RefSeq, PubMed]; These results suggest that Neovastat induces tPA gene transcription through activation of the JNK and NFkappaB signaling pathways, leading to an increase of tPA secretion by endothelial cells., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2KJG9", "ec_number_list": [ { "id": "3.4.21.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.7", "type": "external" }, { "id": "3.4.21.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.68", "type": "external" } ], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0051219 phosphoprotein binding;GO:0097655 serpin family protein binding;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0098978 glutamatergic synapse;GO:0009986 cell surface;GO:0030141 secretory granule;GO:0045177 apical part of cell", "go_biological_process": "GO:0006508 proteolysis;GO:0014909 smooth muscle cell migration;GO:0031639 plasminogen activation;GO:0048008 platelet-derived growth factor receptor signaling pathway;GO:0060468 prevention of polyspermy", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q28198-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VD59-1", "uniprot_id": [ { "id": "MARH8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VD59", "type": "external" } ], "mass": 32780.0, "length": 289, "protein_name": "E3 ubiquitin-protein ligase MARCHF8", "gene_name": "MARCHF8", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase MARCHF8", "refseq_ac": [ { "id": "NP_001069700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069700", "type": "external" } ], "gene_names_uniprotkb": "MARCHF8; MARCH8", "gene_names_refseq": "MARCH8; MARCHF8; c-MIR", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF8; 2.3.2.27; MARCH-VIII; Membrane-associated RING finger protein 8; Membrane-associated RING-CH protein VIII; RING-type E3 ubiquitin transferase MARCHF8", "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH8; E3 ubiquitin-protein ligase MARCHF8; MARCH-VIII; RING-type E3 ubiquitin transferase MARCH8; RING-type E3 ubiquitin transferase MARCHF8; cellular modulator of immune recognition; membrane-associated RING finger protein 8; membrane-associated RING-CH protein VIII; membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase", "tax_id": 9913, "disease": "", "pathway": " (bta:540667)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity. Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins. Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation. Mediates the regulation of constitutive ubiquitination and trafficking of the viral restriction factor BST2 within the endocytic pathway. Plays a role in maintenance of immune tolerance to self by promoting the turnover and proteasomal degradation of PD-L1/CD274 via ubiquitination. Catalyzes the 'Lys-63'-linked polyubiquitylation of cGAS thereby inhibiting its DNA binding ability and impairing its antiviral innate immunity. Negatively regulates IL7-mediated T-cell homeostasis by mediating 'Lys-27'-linked polyubiquitination of IL7R, leading to its lysosomal degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0042287 MHC protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response;GO:0000209 protein polyubiquitination;GO:0002495 antigen processing and presentation of peptide antigen via MHC class II;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VD59-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JQD7-1", "uniprot_id": [ { "id": "MOCS1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JQD7", "type": "external" } ], "mass": 69659.0, "length": 633, "protein_name": "Molybdenum cofactor biosynthesis protein 1", "gene_name": "MOCS1", "organism": "Bovine", "refseq_name": "molybdenum cofactor biosynthesis protein 1 isoform b", "refseq_ac": [ { "id": "NP_001013615", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013615", "type": "external" } ], "gene_names_uniprotkb": "MOCS1", "gene_names_refseq": "MOCS1", "protein_names_uniprotkb": "Molybdenum cofactor biosynthesis protein 1; MOCS1A; MOCS1B; Molybdenum cofactor biosynthesis protein A; Molybdenum cofactor biosynthesis protein C", "protein_names_refseq": "molybdenum cofactor biosynthesis protein 1 isoform b; molybdenum cofactor biosynthesis protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:281917); (R-BTA-947581)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cPMP., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A8SMN8;Q58DL6", "ec_number_list": [ { "id": "4.1.99.22", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.99.22", "type": "external" }, { "id": "4.6.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.17", "type": "external" } ], "go_molecular_function": "GO:0061798 GTP 3',8'-cyclase activity;GO:0061799 cyclic pyranopterin monophosphate synthase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1JQD7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06807-1", "uniprot_id": [ { "id": "TIE2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q06807", "type": "external" } ], "mass": 125927.0, "length": 1125, "protein_name": "Angiopoietin-1 receptor", "gene_name": "TEK", "organism": "Bovine", "refseq_name": "angiopoietin-1 receptor precursor", "refseq_ac": [ { "id": "NP_776389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776389", "type": "external" } ], "gene_names_uniprotkb": "TEK; TIE-2; TIE2", "gene_names_refseq": "TEK", "protein_names_uniprotkb": "Angiopoietin-1 receptor; 2.7.10.1; Endothelial tyrosine kinase; Tyrosine kinase with Ig and EGF homology domains-2; Tyrosine-protein kinase receptor TIE-2", "protein_names_refseq": "TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal); angiopoietin-1 receptor precursor; angiopoietin-1 receptor; endothelial tyrosine kinase; tie-2/tek receptor tyrosine kinase; tyrosine kinase with Ig and EGF homology domains-2; tyrosine-protein kinase receptor TIE-2", "tax_id": 9913, "disease": "", "pathway": " (bta:280939); (R-BTA-210993); (R-BTA-5673001)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "27216150;8415706", "class_list": "", "function": "Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells. Erratum:[Stem Cell Res Ther. 2019 Jan 31;10(1):49. doi: 10.1186/s13287-019-1150-z. PMID: 30704506] Publication Status: Online-Only, [RefSeq, PubMed]; Tyrosine-protein kinase that acts as a cell-surface receptor for ANGPT1, ANGPT2 and ANGPT4 and regulates angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Has anti-inflammatory effects by preventing the leakage of pro-inflammatory plasma proteins and leukocytes from blood vessels. Required for normal angiogenesis and heart development during embryogenesis. Required for post-natal hematopoiesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. ANGPT1 signaling triggers receptor dimerization and autophosphorylation at specific tyrosine residues that then serve as binding sites for scaffold proteins and effectors. Signaling is modulated by ANGPT2 that has lower affinity for TEK, can promote TEK autophosphorylation in the absence of ANGPT1, but inhibits ANGPT1-mediated signaling by competing for the same binding site. Signaling is also modulated by formation of heterodimers with TIE1, and by proteolytic processing that gives rise to a soluble TEK extracellular domain. The soluble extracellular domain modulates signaling by functioning as decoy receptor for angiopoietins. TEK phosphorylates DOK2, GRB7, GRB14, PIK3R1, SHC1 and TIE1 (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0046872 metal ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0043235 receptor complex", "go_biological_process": "GO:0032878 regulation of establishment or maintenance of cell polarity;GO:0001525 angiogenesis;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007507 heart development;GO:0043410 positive regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q06807-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A452DJC8-1", "uniprot_id": [ { "id": "A0A452DJC8_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A452DJC8", "type": "external" } ], "mass": 47161.0, "length": 413, "protein_name": "Uridylate-specific endoribonuclease", "gene_name": "ENDOU", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENDOU", "gene_names_refseq": "", "protein_names_uniprotkb": "Uridylate-specific endoribonuclease; 4.6.1.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoribonuclease that cleaves single-stranded RNAs at 5' of uridylates and releases a product with a 2',3'-cyclic phosphate at the 3'-end. The UU and GU sites are more efficiently cleaved than CU and AU sites. Targets mRNAs to regulate their expression., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0003723 RNA binding;GO:0005044 scavenger receptor activity;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm", "go_biological_process": "GO:0006955 immune response;GO:0006508 proteolysis;GO:0050995 negative regulation of lipid catabolic process;GO:0007565 female pregnancy;GO:0016441 post-transcriptional gene silencing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A452DJC8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5I0-1", "uniprot_id": [ { "id": "MEN1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5I0", "type": "external" } ], "mass": 67384.0, "length": 610, "protein_name": "Menin", "gene_name": "MEN1", "organism": "Bovine", "refseq_name": "menin", "refseq_ac": [ { "id": "NP_001069629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069629", "type": "external" } ], "gene_names_uniprotkb": "MEN1", "gene_names_refseq": "MEN1; menin", "protein_names_uniprotkb": "Menin", "protein_names_refseq": "menin; multiple endocrine neoplasia I; multiple endocrine neoplasia type I", "tax_id": 9913, "disease": "", "pathway": " (bta:539431); (R-BTA-201722); (R-BTA-2173796); (R-BTA-381426); (R-BTA-5626467); (R-BTA-8957275); (R-BTA-9772755)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "28710500", "class_list": "", "function": "Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; MEN1/Menin could play a regulatory role in milk protein synthesis. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0000976 transcription cis-regulatory region binding;GO:0000403 Y-form DNA binding;GO:0003677 DNA binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0000785 chromatin;GO:0035097 histone methyltransferase complex;GO:0005634 nucleus;GO:0005829 cytosol;GO:0016363 nuclear matrix", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0006325 chromatin organization;GO:0045786 negative regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0P5I0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIG3-1", "uniprot_id": [ { "id": "CBPB2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIG3", "type": "external" } ], "mass": 48822.0, "length": 423, "protein_name": "Carboxypeptidase B2", "gene_name": "CPB2", "organism": "Bovine", "refseq_name": "carboxypeptidase B2 precursor", "refseq_ac": [ { "id": "NP_001039462", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039462", "type": "external" } ], "gene_names_uniprotkb": "CPB2", "gene_names_refseq": "CPB2; CPU; TAFI; pCPB", "protein_names_uniprotkb": "Carboxypeptidase B2; 3.4.17.20; CPU; Carboxypeptidase U; Plasma carboxypeptidase B; TAFI; Thrombin-activable fibrinolysis inhibitor; pCPB", "protein_names_refseq": "carboxypeptidase B2 (plasma); carboxypeptidase B2 precursor; carboxypeptidase U; plasma carboxypeptidase B; thrombin-activable fibrinolysis inhibitor; thrombin-activatable fibrinolysis inhibitor", "tax_id": 9913, "disease": "", "pathway": " (bta:508222); (R-BTA-2022377); (R-BTA-977606)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "18669641;18722183;19416536", "class_list": "", "function": "Analysis of the crystal structure of thrombin-activable fibrinolysis inhibitor (TAFI) and description of the structural basis for its intrinsic activity and the short half-life of TAFIa, [RefSeq, PubMed]; Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Findings presented here suggest that the properties of these two orthologous proteins are similar and that conclusions reached using the bovine TAFI may be extrapolated to the human TAFI protein. Publication Status: Online-Only, [RefSeq, PubMed]; Purified bovine TAFI activated in the presence of a proteinaceous inhibitor renders a stable enzyme-inhibitor complex., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 4, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 4, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 4, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.17.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.2", "type": "external" }, { "id": "3.4.17.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.3", "type": "external" }, { "id": "3.4.17.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.20", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation;GO:0042730 fibrinolysis", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q2KIG3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000010000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01061-1", "uniprot_id": [ { "id": "PDE1B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q01061", "type": "external" } ], "mass": 61006.0, "length": 534, "protein_name": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B", "gene_name": "PDE1B", "organism": "Bovine", "refseq_name": "dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B", "refseq_ac": [ { "id": "NP_776840", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776840", "type": "external" } ], "gene_names_uniprotkb": "PDE1B; PDE1B1", "gene_names_refseq": "PDE1B", "protein_names_uniprotkb": "Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; 3.1.4.17; 63 kDa Cam-PDE; Cam-PDE 1B", "protein_names_refseq": "63 kDa Cam-PDE; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; cam-PDE 1B; dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; phosphodiesterase 1B, calmodulin-dependent", "tax_id": 9913, "disease": "", "pathway": " (bta:281970)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1326531;1651112;21960012", "class_list": "", "function": "Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a preference for cGMP as a substrate., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The PDE1B gene is a candidate gene for carcass traits of beef cattle., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0043025 neuronal cell body", "go_biological_process": "GO:0007165 signal transduction;GO:0141162 negative regulation of cAMP/PKA signal transduction;GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus;GO:0030224 monocyte differentiation;GO:0036006 cellular response to macrophage colony-stimulating factor stimulus", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q01061-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DZ8-1", "uniprot_id": [ { "id": "PRIPO_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DZ8", "type": "external" } ], "mass": 63721.0, "length": 555, "protein_name": "DNA-directed primase/polymerase protein", "gene_name": "PRIMPOL", "organism": "Bovine", "refseq_name": "DNA-directed primase/polymerase protein", "refseq_ac": [ { "id": "NP_001068956", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068956", "type": "external" } ], "gene_names_uniprotkb": "PRIMPOL", "gene_names_refseq": "CCDC111; PRIMPOL", "protein_names_uniprotkb": "DNA-directed primase/polymerase protein; 2.7.7.102; 2.7.7.7", "protein_names_refseq": "DNA-directed primase/polymerase protein; coiled-coil domain containing 111; coiled-coil domain-containing protein 111; primase and polymerase (DNA-directed)", "tax_id": 9913, "disease": "", "pathway": " (bta:511080)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesions, such as ultraviolet (UV) lesions, R-loops and G-quadruplexes, to allow DNA replication to continue. Can also realign primers ahead of 'unreadable lesions' such as abasic sites and 6-4 photoproduct (6-4 pyrimidine-pyrimidinone), thereby skipping the lesion. Repriming avoids fork degradation while leading to accumulation of internal ssDNA gaps behind the forks. Also able to incorporate nucleotides opposite DNA lesions such as 8oxoG, like a regular translesion synthesis DNA polymerase. Also required for reinitiating stalled forks after UV damage during nuclear DNA replication. Required for mitochondrial DNA (mtDNA) synthesis and replication, by reinitiating synthesis after UV damage or in the presence of chain-terminating nucleotides (By similarity). Prevents APOBEC family-mediated DNA mutagenesis by repriming downstream of abasic site to prohibit error-prone translesion synthesis (By similarity). Has non-overlapping function with POLH. In addition to its role in DNA damage response, also required to maintain efficient nuclear and mitochondrial DNA replication in unperturbed cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0030145 manganese ion binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005759 mitochondrial matrix;GO:0005657 replication fork;GO:0000428 DNA-directed RNA polymerase complex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0009411 response to UV;GO:0019985 translesion synthesis;GO:0006269 DNA replication, synthesis of primer;GO:0006264 mitochondrial DNA replication;GO:0043504 mitochondrial DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DZ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DJ8-1", "uniprot_id": [ { "id": "HSF1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DJ8", "type": "external" } ], "mass": 56702.0, "length": 525, "protein_name": "Heat shock factor protein 1", "gene_name": "HSF1", "organism": "Bovine", "refseq_name": "heat shock factor protein 1", "refseq_ac": [ { "id": "NP_001070277", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070277", "type": "external" } ], "gene_names_uniprotkb": "HSF1", "gene_names_refseq": "HSF1; HSF", "protein_names_uniprotkb": "Heat shock factor protein 1; HSF 1; HSTF 1; Heat shock transcription factor 1", "protein_names_refseq": "HSF 1; HSTF 1; heat shock factor 1; heat shock factor 2; heat shock factor protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:506235); (R-BTA-3371453); (R-BTA-3371511); (R-BTA-3371568); (R-BTA-3371571); (R-BTA-9841251)", "pathway_count": 6, "publication_count": 4, "publication_id_list": "21189066;28451769;31228509;31466795", "class_list": "", "function": "As the 4693-T mutation caused the disruption of microRNA target binding (resulting in the relief of the transcriptional repression), the HSF1 gene is useful in dairy cattle thermal tolerant breeding., [RefSeq, PubMed]; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage. In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes. Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival. Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form. Binds to inverted 5'-NGAAN-3' pentamer DNA sequences. Binds to chromatin at heat shock gene promoters. Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2. Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells. Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner. Plays a role in nuclear export of stress-induced HSP70 mRNA. Plays a role in the regulation of mitotic progression. Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner. Involved in stress-induced cancer cell proliferation in a IER5-dependent manner., [UniProtKB, UniProtKB]; Respiratory rate, rectal temperature and expression of the HSF1 and HSPA6 genes can be indicators of thermotolerance in taurine cattle., [RefSeq, PubMed]; The association between the HSF 1 expression and antioxidative activity through correlation analysis was found to be non-significant, though enzymatic activity appeared to behave in a similar fashion in both breeds at 5% level of significance, thus ruling out the role of HSF1 expression level on the activity of enzymes involved in oxidative stress in vitro in zebu and crossbred cattle., [RefSeq, PubMed]; We conclude that Bovine leukemia virus long terminal repeat is activated to a basal level by host transcriptional factor HSF1, but without Tax protein involvement., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0045931 positive regulation of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q08DJ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNJ4-1", "uniprot_id": [ { "id": "ZN692_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNJ4", "type": "external" } ], "mass": 55474.0, "length": 510, "protein_name": "Zinc finger protein 692", "gene_name": "ZNF692", "organism": "Bovine", "refseq_name": "zinc finger protein 692", "refseq_ac": [ { "id": "NP_001019667", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019667", "type": "external" } ], "gene_names_uniprotkb": "ZNF692; AREBP; ZFP692", "gene_names_refseq": "ZNF692", "protein_names_uniprotkb": "Zinc finger protein 692; AICAR responsive element binding protein", "protein_names_refseq": "AICAR responsive element binding protein; zinc finger protein 692", "tax_id": 9913, "disease": "", "pathway": " (bta:507847)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as an transcriptional repressor for PCK1 gene expression, in turn may participate in the hepatic gluconeogenesis regulation through the activated AMPK signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006111 regulation of gluconeogenesis;GO:0080090 regulation of primary metabolic process;GO:0060255 regulation of macromolecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNJ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIA0-1", "uniprot_id": [ { "id": "MEF2C_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIA0", "type": "external" } ], "mass": 47844.0, "length": 441, "protein_name": "Myocyte-specific enhancer factor 2C", "gene_name": "MEF2C", "organism": "Bovine", "refseq_name": "myocyte-specific enhancer factor 2C", "refseq_ac": [ { "id": "NP_001039578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039578", "type": "external" } ], "gene_names_uniprotkb": "MEF2C", "gene_names_refseq": "MEF2C", "protein_names_uniprotkb": "Myocyte-specific enhancer factor 2C", "protein_names_refseq": "MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C); myocyte-specific enhancer factor 2C", "tax_id": 9913, "disease": "", "pathway": " (bta:512254); (R-BTA-525793)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "20585884;25108515", "class_list": "", "function": "Analysis of sequence and variations of the bovine myocyte enhancer factor 2C (MEF2C) gene promoter in Bos taurus cattle, [RefSeq, PubMed]; The myocyte enhancer factor 2 family of MADS is highly expressed in cells of muscle lineage, where they have been proven to be important regulators of gene expression during the development of skeletal, cardiac and smooth muscle., [RefSeq, PubMed]; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0042826 histone deacetylase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0032991 protein-containing complex;GO:0016528 sarcoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0007611 learning or memory;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2KIA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNI5-1", "uniprot_id": [ { "id": "CLASR_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNI5", "type": "external" } ], "mass": 76791.0, "length": 670, "protein_name": "CLK4-associating serine/arginine rich protein", "gene_name": "CLASRP", "organism": "Bovine", "refseq_name": "CLK4-associating serine/arginine rich protein", "refseq_ac": [ { "id": "NP_001071355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071355", "type": "external" } ], "gene_names_uniprotkb": "CLASRP; SFRS16", "gene_names_refseq": "CLASRP; SFRS16", "protein_names_uniprotkb": "CLK4-associating serine/arginine rich protein; Splicing factor, arginine/serine-rich 16", "protein_names_refseq": "CLK4-associating serine/arginine rich protein; splicing factor, arginine/serine-rich 16", "tax_id": 9913, "disease": "", "pathway": " (bta:509208)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probably functions as an alternative splicing regulator. May regulate the mRNA splicing of genes such as CLK1. May act by regulating members of the CLK kinase family (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNI5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ61-1", "uniprot_id": [ { "id": "PLPP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ61", "type": "external" } ], "mass": 32328.0, "length": 287, "protein_name": "Phospholipid phosphatase 2", "gene_name": "PLPP2", "organism": "Bovine", "refseq_name": "phospholipid phosphatase 2", "refseq_ac": [ { "id": "NP_001039355", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039355", "type": "external" } ], "gene_names_uniprotkb": "PLPP2; PPAP2C", "gene_names_refseq": "PLPP2; PPAP2C", "protein_names_uniprotkb": "Phospholipid phosphatase 2; 3.1.3.-; 3.1.3.4; Lipid phosphate phosphohydrolase 2; PAP-2c; PAP2-G; PAP2-gamma; PAP2c; Phosphatidate phosphohydrolase type 2c; Phosphatidic acid phosphatase 2c", "protein_names_refseq": "PAP-2c; PAP2-G; PAP2-gamma; PAP2c; lipid phosphate phosphohydrolase 2; phosphatidate phosphohydrolase type 2c; phosphatidic acid phosphatase 2c; phosphatidic acid phosphatase type 2C; phospholipid phosphatase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:504545); (R-BTA-9845614)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (By similarity). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.6.1.68", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68", "type": "external" } ], "go_molecular_function": "GO:0008195 phosphatidate phosphatase activity;GO:0042392 sphingosine-1-phosphate phosphatase activity;GO:0106235 ceramide-1-phosphate phosphatase activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006670 sphingosine metabolic process;GO:0007165 signal transduction;GO:0006672 ceramide metabolic process;GO:0006644 phospholipid metabolic process;GO:0046839 phospholipid dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ61-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJA5-1", "uniprot_id": [ { "id": "DTBP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJA5", "type": "external" } ], "mass": 38207.0, "length": 342, "protein_name": "Dysbindin", "gene_name": "DTNBP1", "organism": "Bovine", "refseq_name": "dysbindin", "refseq_ac": [ { "id": "NP_001039412", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039412", "type": "external" } ], "gene_names_uniprotkb": "DTNBP1; BLOC1S8", "gene_names_refseq": "DTNBP1", "protein_names_uniprotkb": "Dysbindin; BLOC-1 subunit 8; Biogenesis of lysosome-related organelles complex 1 subunit 8; Dysbindin-1; Dystrobrevin-binding protein 1", "protein_names_refseq": "BLOC-1 subunit 8; biogenesis of lysosome-related organelles complex 1 subunit 8; dysbindin-1; dysbindin", "tax_id": 9913, "disease": "", "pathway": " (bta:506612); (R-BTA-432722)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0030426 growth cone", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0031175 neuron projection development;GO:0014059 regulation of dopamine secretion;GO:0048812 neuron projection morphogenesis;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJA5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9SJE4-1", "uniprot_id": [ { "id": "A0AAA9SJE4_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9SJE4", "type": "external" } ], "mass": 53186.0, "length": 462, "protein_name": "Phosphatidate cytidylyltransferase", "gene_name": "CDS1", "organism": "Bovine", "refseq_name": "phosphatidate cytidylyltransferase 1", "refseq_ac": [ { "id": "XP_003586270", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003586270", "type": "external" } ], "gene_names_uniprotkb": "CDS1", "gene_names_refseq": "CDS1", "protein_names_uniprotkb": "Phosphatidate cytidylyltransferase; 2.7.7.41", "protein_names_refseq": "phosphatidate cytidylyltransferase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:100336936); (R-BTA-1483226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.41", "type": "external" } ], "go_molecular_function": "GO:0004605 phosphatidate cytidylyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016024 CDP-diacylglycerol biosynthetic process;GO:0045600 positive regulation of fat cell differentiation;GO:0006661 phosphatidylinositol biosynthetic process;GO:0140042 lipid droplet formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9SJE4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81425-1", "uniprot_id": [ { "id": "DPP4_BOVIN", "url": "https://www.uniprot.org/uniprot/P81425", "type": "external" } ], "mass": 88369.0, "length": 765, "protein_name": "Dipeptidyl peptidase 4", "gene_name": "DPP4", "organism": "Bovine", "refseq_name": "dipeptidyl peptidase 4", "refseq_ac": [ { "id": "NP_776464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776464", "type": "external" } ], "gene_names_uniprotkb": "DPP4; CD26", "gene_names_refseq": "ACT3; ADCP-I; CD26; DPP4; DPPIV; WC10", "protein_names_uniprotkb": "Dipeptidyl peptidase 4; 3.4.14.5; ACT3; ADCP-I; Activation molecule 3; Adenosine deaminase complexing protein; DPP IV; Dipeptidyl peptidase IV membrane form; Dipeptidyl peptidase IV soluble form; Dipeptidyl peptidase IV; T-cell activation antigen CD26; WC10", "protein_names_refseq": "T-cell activation antigen CD26; activation molecule 3; dipeptidyl peptidase 4; dipeptidyl peptidase IV; dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2); dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)", "tax_id": 9913, "disease": "", "pathway": " (bta:281122); (R-BTA-381771); (R-BTA-400511)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "11598101;11981836;12073152;18508455;18774942;20838887;9629661", "class_list": "", "function": "Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, enhanced cell proliferation, a process inhibited by GPC3. Also acts as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones. Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline., [UniProtKB, UniProtKB]; Data demonstrate that dipeptidyl peptidase II can form a complex with adenosine deaminase, but with one order of magnitude higher dissociation constant than that of DPPIV., [RefSeq, PubMed]; Results describe a proline-rich cytokine from neurosecretory granules that represents a new natural substrate for Dipeptidyl Peptidase IV (DPPIV)., [RefSeq, PubMed]; This and other dipeptidyl peptidases can be isolated from bovine testes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 11, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCC2;Q8WMG8", "ec_number_list": [ { "id": "3.4.14.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.14.5", "type": "external" } ], "go_molecular_function": "GO:0008239 dipeptidyl-peptidase activity;GO:0002020 protease binding;GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030027 lamellipodium;GO:0045121 membrane raft", "go_biological_process": "GO:0006508 proteolysis;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0031295 T cell costimulation;GO:0043542 endothelial cell migration", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P81425-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9U2I8-1", "uniprot_id": [ { "id": "A0AAA9U2I8_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9U2I8", "type": "external" } ], "mass": 52794.0, "length": 477, "protein_name": "Methionine aminopeptidase 2", "gene_name": "METAP2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "METAP2", "gene_names_refseq": "", "protein_names_uniprotkb": "Methionine aminopeptidase 2; 3.4.11.18; Initiation factor 2-associated 67 kDa glycoprotein; MAP 2; MetAP 2; Peptidase M; p67eIF2; p67", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2514859)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]; Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.18", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0070006 metalloaminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing;GO:0006446 regulation of translational initiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9U2I8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9TA90-1", "uniprot_id": [ { "id": "A0AAA9TA90_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9TA90", "type": "external" } ], "mass": 39273.0, "length": 344, "protein_name": "L-Fucosyltransferase", "gene_name": "FUT2", "organism": "Bovine", "refseq_name": "galactoside alpha-(1,2)-fucosyltransferase 2 isoform X1", "refseq_ac": [ { "id": "XP_005219210", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005219210", "type": "external" } ], "gene_names_uniprotkb": "FUT2", "gene_names_refseq": "FUT2; Se; sec1", "protein_names_uniprotkb": "L-Fucosyltransferase; 2.4.1.-", "protein_names_refseq": "galactoside alpha-(1,2)-fucosyltransferase 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9033807); (R-BTA-9037629); (R-BTA-9840309)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation. Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.344", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.344", "type": "external" }, { "id": "2.4.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.69", "type": "external" } ], "go_molecular_function": "GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0005975 carbohydrate metabolic process;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9TA90-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9SXG3-1", "uniprot_id": [ { "id": "A0AAA9SXG3_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9SXG3", "type": "external" } ], "mass": 39710.0, "length": 351, "protein_name": "D-amino-acid oxidase", "gene_name": "DAO", "organism": "Bovine", "refseq_name": "D-amino-acid oxidase isoform X1", "refseq_ac": [ { "id": "XP_015330977", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015330977", "type": "external" } ], "gene_names_uniprotkb": "DAO", "gene_names_refseq": "DAO", "protein_names_uniprotkb": "D-amino-acid oxidase; 1.4.3.3", "protein_names_refseq": "D-amino-acid oxidase isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-389661); (R-BTA-9033241)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" } ], "go_molecular_function": "GO:0071949 FAD binding;GO:0003884 D-amino-acid oxidase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005782 peroxisomal matrix;GO:0005829 cytosol;GO:0048786 presynaptic active zone;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0036088 D-serine catabolic process;GO:0055130 D-alanine catabolic process;GO:0006562 L-proline catabolic process;GO:0046416 D-amino acid metabolic process;GO:0042416 dopamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9SXG3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9TEN6-1", "uniprot_id": [ { "id": "A0AAA9TEN6_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9TEN6", "type": "external" } ], "mass": 62701.0, "length": 590, "protein_name": "Glutathione hydrolase 5 proenzyme", "gene_name": "GGT5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GGT5", "gene_names_refseq": "", "protein_names_uniprotkb": "Glutathione hydrolase 5 proenzyme; 2.3.2.2; 3.4.19.13; 3.4.19.14; Gamma-glutamyl leukotrienase; Gamma-glutamyltransferase 5; Gamma-glutamyltransferase-like activity 1; Gamma-glutamyltranspeptidase 5; Leukotriene-C4 hydrolase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:787326); (R-BTA-174403); (R-BTA-2142691); (R-BTA-5423646); (R-BTA-9753281)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.2", "type": "external" }, { "id": "3.4.19.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.13", "type": "external" }, { "id": "3.4.19.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.14", "type": "external" } ], "go_molecular_function": "GO:0002951 leukotriene-C(4) hydrolase;GO:0036374 glutathione hydrolase activity;GO:0103068 leukotriene C4 gamma-glutamyl transferase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0006750 glutathione biosynthetic process;GO:0006751 glutathione catabolic process;GO:0006508 proteolysis;GO:0006954 inflammatory response;GO:1901750 leukotriene D4 biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9TEN6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA25-1", "uniprot_id": [ { "id": "PLK1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TA25", "type": "external" } ], "mass": 68000.0, "length": 602, "protein_name": "Serine/threonine-protein kinase PLK1", "gene_name": "PLK1", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase PLK1", "refseq_ac": [ { "id": "NP_001033262", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033262", "type": "external" } ], "gene_names_uniprotkb": "PLK1", "gene_names_refseq": "PLK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase PLK1; 2.7.11.21; PLK-1; Polo-like kinase 1", "protein_names_refseq": "PLK-1; serine/threonine-protein kinase PLK1", "tax_id": 9913, "disease": "", "pathway": " (bta:538238); (R-BTA-141430); (R-BTA-141444); (R-BTA-156711); (R-BTA-162658); (R-BTA-174178); (R-BTA-176412); (R-BTA-176417); (R-BTA-2299718); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-2565942); (R-BTA-2980767); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-5663220); (R-BTA-68881); (R-BTA-68884); (R-BTA-69273); (R-BTA-8852276); (R-BTA-8854518); (R-BTA-9648025)", "pathway_count": 25, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, MRE11, PPP1R12A/MYPT1, POLQ, PRC1, RACGAP1/CYK4, RAD51, RHNO1, SGO1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1, WEE1 and HNRNPU. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL. NEDD1 phosphorylation promotes subsequent targeting of the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. Phosphorylation of NINL component of the centrosome leads to NINL dissociation from other centrosomal proteins. Involved in mitosis exit and cytokinesis by phosphorylating CEP55, ECT2, KIF20A/MKLP2, CENPU, PRC1 and RACGAP1. Recruited at the central spindle by phosphorylating and docking PRC1 and KIF20A/MKLP2; creates its own docking sites on PRC1 and KIF20A/MKLP2 by mediating phosphorylation of sites subsequently recognized by the POLO box domains. Phosphorylates RACGAP1, thereby creating a docking site for the Rho GTP exchange factor ECT2 that is essential for the cleavage furrow formation. Promotes the central spindle recruitment of ECT2. Plays a central role in G2/M transition of mitotic cell cycle by phosphorylating CCNB1, CDC25C, FOXM1, CENPU, PKMYT1/MYT1, PPP1R12A/MYPT1 and WEE1. Part of a regulatory circuit that promotes the activation of CDK1 by phosphorylating the positive regulator CDC25C and inhibiting the negative regulators WEE1 and PKMYT1/MYT1. Also acts by mediating phosphorylation of cyclin-B1 (CCNB1) on centrosomes in prophase. Phosphorylates FOXM1, a key mitotic transcription regulator, leading to enhance FOXM1 transcriptional activity. Involved in kinetochore functions and sister chromatid cohesion by phosphorylating BUB1B/BUBR1, FBXO5/EMI1 and STAG2/SA2. PLK1 is high on non-attached kinetochores suggesting a role of PLK1 in kinetochore attachment or in spindle assembly checkpoint (SAC) regulation. Required for kinetochore localization of BUB1B. Regulates the dissociation of cohesin from chromosomes by phosphorylating cohesin subunits such as STAG2/SA2. Phosphorylates SGO1: required for spindle pole localization of isoform 3 of SGO1 and plays a role in regulating its centriole cohesion function. Mediates phosphorylation of FBXO5/EMI1, a negative regulator of the APC/C complex during prophase, leading to FBXO5/EMI1 ubiquitination and degradation by the proteasome. Acts as a negative regulator of p53 family members: phosphorylates TOPORS, leading to inhibit the sumoylation of p53/TP53 and simultaneously enhance the ubiquitination and subsequent degradation of p53/TP53. Phosphorylates the transactivation domain of the transcription factor p73/TP73, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Also required for recovery after DNA damage checkpoint and entry into mitosis. Phosphorylates MISP, leading to stabilization of cortical and astral microtubule attachments required for proper spindle positioning. Together with MEIKIN, acts as a regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Phosphorylates CEP68 and is required for its degradation. Regulates nuclear envelope breakdown during prophase by phosphorylating DCTN1 resulting in its localization in the nuclear envelope. Phosphorylates the heat shock transcription factor HSF1, promoting HSF1 nuclear translocation upon heat shock. Phosphorylates HSF1 also in the early mitotic period; this phosphorylation regulates HSF1 localization to the spindle pole, the recruitment of the SCF(BTRC) ubiquitin ligase complex induicing HSF1 degradation, and hence mitotic progression. Regulates mitotic progression by phosphorylating RIOK2. Through the phosphorylation of DZIP1 regulates the localization during mitosis of the BBSome, a ciliary protein complex involved in cilium biogenesis. Regulates DNA repair during mitosis by mediating phosphorylation of POLQ and RHNO1, thereby promoting POLQ recruitment to DNA damage sites (By similarity). Phosphorylates ATXN10 which may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1N225", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.4.22.49", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.49", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle", "go_biological_process": "GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:1903673 mitotic cleavage furrow formation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0000278 mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TA25-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P595-1", "uniprot_id": [ { "id": "SIR7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P595", "type": "external" } ], "mass": 45043.0, "length": 400, "protein_name": "NAD-dependent protein deacetylase sirtuin-7", "gene_name": "SIRT7", "organism": "Bovine", "refseq_name": "NAD-dependent protein deacetylase sirtuin-7", "refseq_ac": [ { "id": "NP_001068685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068685", "type": "external" } ], "gene_names_uniprotkb": "SIRT7", "gene_names_refseq": "SIRT7", "protein_names_uniprotkb": "NAD-dependent protein deacetylase sirtuin-7; 2.3.1.-; 2.3.1.286; NAD-dependent protein deacylase sirtuin-7; Regulatory protein SIR2 homolog 7; SIR2-like protein 7", "protein_names_refseq": "NAD-dependent deacetylase sirtuin-7; NAD-dependent protein deacetylase sirtuin-7; NAD-dependent protein deacylase sirtuin-7; SIR2-like protein 7; regulatory protein SIR2 homolog 7", "tax_id": 9913, "disease": "", "pathway": " (bta:505662)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "NAD-dependent protein-lysine deacylase that can act both as a deacetylase or deacylase (desuccinylase, depropionylase, deglutarylase and dedecanoylase), depending on the context. Specifically mediates deacetylation of histone H3 at 'Lys-18' (H3K18Ac). In contrast to other histone deacetylases, displays strong preference for a specific histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors; SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. Also able to mediate deacetylation of histone H3 at 'Lys-36' (H3K36Ac) in the context of nucleosomes. Also mediates deacetylation of non-histone proteins, such as ATM, CDK9, DDX21, DDB1, FBL, FKBP5/FKBP51, GABPB1, RAN, RRP9/U3-55K and POLR1E/PAF53. Enriched in nucleolus where it stimulates transcription activity of the RNA polymerase I complex. Acts by mediating the deacetylation of the RNA polymerase I subunit POLR1E/PAF53, thereby promoting the association of RNA polymerase I with the rDNA promoter region and coding region. In response to metabolic stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased RNA polymerase I transcription. Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. Promotes pre-ribosomal RNA (pre-rRNA) cleavage at the 5'-terminal processing site by mediating deacetylation of RRP9/U3-55K, a core subunit of the U3 snoRNP complex. Mediates 'Lys-37' deacetylation of Ran, thereby regulating the nuclear export of NF-kappa-B subunit RELA/p65. Acts as a regulator of DNA damage repair by mediating deacetylation of ATM during the late stages of DNA damage response, promoting ATM dephosphorylation and deactivation. Suppresses the activity of the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes by mediating deacetylation of DDB1, which prevents the interaction between DDB1 and CUL4 (CUL4A or CUL4B). Activates RNA polymerase II transcription by mediating deacetylation of CDK9, thereby promoting 'Ser-2' phosphorylation of the C-terminal domain (CTD) of RNA polymerase II. Deacetylates FBL, promoting histone-glutamine methyltransferase activity of FBL (By similarity). Acts as a regulator of mitochondrial function by catalyzing deacetylation of GABPB1 (By similarity). Regulates Akt/AKT1 activity by mediating deacetylation of FKBP5/FKBP51. Required to prevent R-loop-associated DNA damage and transcription-associated genomic instability by mediating deacetylation and subsequent activation of DDX21, thereby overcoming R-loop-mediated stalling of RNA polymerases. In addition to protein deacetylase activity, also acts as a protein-lysine deacylase (By similarity). Acts as a protein depropionylase by mediating depropionylation of Osterix (SP7), thereby regulating bone formation by osteoblasts (By similarity). Acts as a histone deglutarylase by mediating deglutarylation of histone H4 on 'Lys-91' (H4K91glu); a mark that destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes. Acts as a histone desuccinylase: in response to DNA damage, recruited to DNA double-strand breaks (DSBs) and catalyzes desuccinylation of histone H3 on 'Lys-122' (H3K122succ), thereby promoting chromatin condensation and DSB repair (By similarity). Also promotes DSB repair by promoting H3K18Ac deacetylation, regulating non-homologous end joining (NHEJ). Along with its role in DNA repair, required for chromosome synapsis during prophase I of female meiosis by catalyzing H3K18Ac deacetylation (By similarity). Involved in transcriptional repression of LINE-1 retrotransposon via H3K18Ac deacetylation, and promotes their association with the nuclear lamina. Required to stabilize ribosomal DNA (rDNA) heterochromatin and prevent cellular senescence induced by rDNA instability (By similarity). Acts as a negative regulator of SIRT1 by preventing autodeacetylation of SIRT1, restricting SIRT1 deacetylase activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" } ], "go_molecular_function": "GO:0036055 protein-succinyllysine desuccinylase activity;GO:0061697 protein-glutaryllysine deglutarylase activity;GO:0097372 histone H3K18 deacetylase activity, NAD-dependent;GO:0003682 chromatin binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005731 nucleolus organizer region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:0061698 protein deglutarylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P595-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMU2-1", "uniprot_id": [ { "id": "CYLD_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMU2", "type": "external" } ], "mass": 106805.0, "length": 953, "protein_name": "Ubiquitin carboxyl-terminal hydrolase CYLD", "gene_name": "CYLD", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase CYLD", "refseq_ac": [ { "id": "NP_001039882", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039882", "type": "external" } ], "gene_names_uniprotkb": "CYLD; CYLD1", "gene_names_refseq": "CYLD", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase CYLD; 3.4.19.12; Deubiquitinating enzyme CYLD; Ubiquitin thioesterase CYLD; Ubiquitin-specific-processing protease CYLD", "protein_names_refseq": "deubiquitinating enzyme CYLD; probable ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin carboxyl-terminal hydrolase CYLD; ubiquitin thioesterase CYLD; ubiquitin thiolesterase CYLD; ubiquitin-specific-processing protease CYLD", "tax_id": 9913, "disease": "", "pathway": " (bta:536421); (R-BTA-168638); (R-BTA-5357786); (R-BTA-5357905); (R-BTA-5357956); (R-BTA-5689880); (R-BTA-936440)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deubiquitinase that specifically cleaves 'Lys-63'- and linear 'Met-1'-linked polyubiquitin chains and is involved in NF-kappa-B activation and TNF-induced necroptosis. Negatively regulates NF-kappa-B activation by deubiquitinating upstream signaling factors. Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation. Negative regulator of Wnt signaling. Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules. Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis. Required for normal cell cycle progress and normal cytokinesis. Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (By similarity). Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis. Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity). Ability to remove linear ('Met-1'-linked) polyubiquitin chains regulates innate immunity and TNF-induced necroptosis: recruited to the LUBAC complex via interaction with SPATA2 and restricts linear polyubiquitin formation on target proteins. Regulates innate immunity by restricting linear polyubiquitin formation on RIPK2 in response to NOD2 stimulation (By similarity). Involved in TNF-induced necroptosis by removing linear ('Met-1'-linked) polyubiquitin chains from RIPK1, thereby regulating the kinase activity of RIPK1 (By similarity). Negatively regulates intestinal inflammation by removing 'Lys-63' linked polyubiquitin chain of NLRP6, thereby reducing the interaction between NLRP6 and PYCARD/ASC and formation of the NLRP6 inflammasome (By similarity). Does not catalyze deubiquitination of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (By similarity). Removes 'Lys-63' linked polyubiquitin chain of MAP3K7, which inhibits phosphorylation and blocks downstream activation of the JNK-p38 kinase cascades (By similarity). Also removes 'Lys-63'-linked polyubiquitin chains of MAP3K1 and MA3P3K3, which inhibit their interaction with MAP2K1 and MAP2K2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity;GO:0046872 metal ion binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0045087 innate immune response;GO:0070536 protein K63-linked deubiquitination;GO:0090090 negative regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMU2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0II22-1", "uniprot_id": [ { "id": "RN126_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0II22", "type": "external" } ], "mass": 33954.0, "length": 313, "protein_name": "E3 ubiquitin-protein ligase RNF126", "gene_name": "RNF126", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase RNF126", "refseq_ac": [ { "id": "NP_001068782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068782", "type": "external" } ], "gene_names_uniprotkb": "RNF126", "gene_names_refseq": "RNF126", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF126; 2.3.2.27; RING finger protein 126", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF126", "tax_id": 9913, "disease": "", "pathway": " (bta:507447); (R-BTA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins. Depending on the associated E2 ligase, mediates 'Lys-27'-, 'Lys-29'-, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates. Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome. Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome. May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor. May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination. By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation. May monoubiquitinate AICDA. Acts as a regulator of DNA repair by mediating 'Lys-27'- and 'Lys-29'-linked polyubiquitination of MRE11, thereby promoting the exonuclease activity of MRE11 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0042147 retrograde transport, endosome to Golgi;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0II22-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RML1-1", "uniprot_id": [ { "id": "UBE2S_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RML1", "type": "external" } ], "mass": 23896.0, "length": 223, "protein_name": "Ubiquitin-conjugating enzyme E2 S", "gene_name": "UBE2S", "organism": "Bovine", "refseq_name": "ubiquitin-conjugating enzyme E2 S", "refseq_ac": [ { "id": "NP_001069940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069940", "type": "external" } ], "gene_names_uniprotkb": "UBE2S", "gene_names_refseq": "UBE2S", "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 S; 2.3.2.23; E2 ubiquitin-conjugating enzyme S; Ubiquitin carrier protein S; Ubiquitin-protein ligase S", "protein_names_refseq": "E2 ubiquitin-conjugating enzyme S; ubiquitin carrier protein S; ubiquitin-conjugating enzyme E2 S; ubiquitin-conjugating enzyme E2S; ubiquitin-protein ligase S", "tax_id": 9913, "disease": "", "pathway": " (bta:617703); (R-BTA-141430); (R-BTA-174048); (R-BTA-174084); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-176407); (R-BTA-176408); (R-BTA-176409); (R-BTA-176412); (R-BTA-179409); (R-BTA-2467813); (R-BTA-2559582); (R-BTA-68867); (R-BTA-69017); (R-BTA-8866652); (R-BTA-983168)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QLZ2", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "6.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0061631 ubiquitin conjugating enzyme activity;GO:0010997 anaphase-promoting complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0010458 exit from mitosis;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:1904668 positive regulation of ubiquitin protein ligase activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RML1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZB3-1", "uniprot_id": [ { "id": "S2533_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZB3", "type": "external" } ], "mass": 35378.0, "length": 321, "protein_name": "Solute carrier family 25 member 33", "gene_name": "SLC25A33", "organism": "Bovine", "refseq_name": "solute carrier family 25 member 33", "refseq_ac": [ { "id": "XP_010811602", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811602", "type": "external" } ], "gene_names_uniprotkb": "SLC25A33", "gene_names_refseq": "SLC25A33", "protein_names_uniprotkb": "Solute carrier family 25 member 33", "protein_names_refseq": "solute carrier family 25 member 33", "tax_id": 9913, "disease": "", "pathway": " (bta:533794)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial transporter that imports/exports pyrimidine nucleotides into and from mitochondria. Selectively transports uridine, thymidine, guanosine, cytosine and inosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism (By similarity). May import (deoxy)nucleoside triphosphates in exchange for intramitochondrial (deoxy)nucleoside diphosphates, thus providing precursors necessary for de novo synthesis of mitochondrial DNA and RNA while exporting products of their catabolism (By similarity). Participates in mitochondrial genome maintenance, regulation of mitochondrial membrane potential and mitochondrial respiration (By similarity). Upon INS or IGF1 stimulation regulates cell growth and proliferation by controlling mitochondrial DNA replication and transcription, the ratio of mitochondria-to nuclear-encoded components of the electron transport chain resulting in control of mitochondrial ROS production (By similarity). Participates in dendritic cell endocytosis and may associate with mitochondrial oxidative phosphorylation (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015218 pyrimidine nucleotide transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0032869 cellular response to insulin stimulus;GO:0007005 mitochondrion organization;GO:0002082 regulation of oxidative phosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1LZB3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ97-1", "uniprot_id": [ { "id": "PHB2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ97", "type": "external" } ], "mass": 33357.0, "length": 299, "protein_name": "Prohibitin-2", "gene_name": "PHB2", "organism": "Bovine", "refseq_name": "prohibitin-2", "refseq_ac": [ { "id": "NP_001039663", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039663", "type": "external" } ], "gene_names_uniprotkb": "PHB2", "gene_names_refseq": "PHB2; REA", "protein_names_uniprotkb": "Prohibitin-2", "protein_names_refseq": "B-cell associated protein; B-cell receptor-associated protein 37; prohibitin-2", "tax_id": 9913, "disease": "", "pathway": " (bta:515363); (R-BTA-8949664); (R-BTA-9840373)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "In the mitochondria, together with PHB, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In the mitochondria, together with PHB1, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan. The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner. Also regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity. Has a key role of mitophagy receptor involved in targeting mitochondria for autophagic degradation. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6., [UniProtKB, UniProtKB]; In the nucleus, serves as transcriptional co-regulator. Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; In the plasma membrane, is involved in IGFBP6-induced cell migration (By similarity). Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; In the plasma membrane, is involved in IGFBP6-induced cell migration. Cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates. Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046625 sphingolipid binding;GO:0033218 amide binding;GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016477 cell migration;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0042113 B cell activation;GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ97-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28043-1", "uniprot_id": [ { "id": "AVR2A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28043", "type": "external" } ], "mass": 57952.0, "length": 513, "protein_name": "Activin receptor type-2A", "gene_name": "ACVR2A", "organism": "Bovine", "refseq_name": "activin receptor type-2A precursor", "refseq_ac": [ { "id": "NP_776652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776652", "type": "external" } ], "gene_names_uniprotkb": "ACVR2A; ACTRII; ACVR2", "gene_names_refseq": "ACVR2A; ACVR2", "protein_names_uniprotkb": "Activin receptor type-2A; 2.7.11.30; ACTR-IIA; Activin receptor type IIA", "protein_names_refseq": "ACTR-IIA; activin A receptor, type IIA; activin A receptor, type II; activin receptor type-2A precursor; activin receptor type-2A; activin receptor, type IIA", "tax_id": 9913, "disease": "", "pathway": " (bta:281598); (R-BTA-1502540); (R-BTA-201451); (R-BTA-9839406)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "26486459;29716627;7534730;8875905", "class_list": "", "function": "MiRNA-424/503 cluster members target the SMAD7 and ACVR2A genes which are involved in the activin signalling pathway Publication Status: Online-Only, [RefSeq, PubMed]; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This genome-wide association study identified variants in the upstream region of ACVR2A, which were associated with female fertility in Japanese Black cattle. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A5D7L7", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0048185 activin binding;GO:0098821 BMP receptor activity;GO:0017002 activin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048179 activin receptor complex;GO:0005737 cytoplasm;GO:0009986 cell surface;GO:0043235 receptor complex", "go_biological_process": "GO:0071363 cellular response to growth factor stimulus;GO:0030509 BMP signaling pathway;GO:0032924 activin receptor signaling pathway;GO:0007389 pattern specification process;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q28043-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA49-1", "uniprot_id": [ { "id": "VASP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TA49", "type": "external" } ], "mass": 40463.0, "length": 383, "protein_name": "Vasodilator-stimulated phosphoprotein", "gene_name": "VASP", "organism": "Bovine", "refseq_name": "vasodilator-stimulated phosphoprotein", "refseq_ac": [ { "id": "NP_001033199", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033199", "type": "external" } ], "gene_names_uniprotkb": "VASP", "gene_names_refseq": "VASP", "protein_names_uniprotkb": "Vasodilator-stimulated phosphoprotein; VASP", "protein_names_refseq": "vasodilator-stimulated phosphoprotein", "tax_id": 9913, "disease": "", "pathway": " (bta:514902)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035256 G protein-coupled glutamate receptor binding;GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0042802 identical protein binding;GO:0005522 profilin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005923 bicellular tight junction", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0008154 actin polymerization or depolymerization;GO:0030838 positive regulation of actin filament polymerization;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:2001256 regulation of store-operated calcium entry", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TA49-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJF7-1", "uniprot_id": [ { "id": "KCC2D_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJF7", "type": "external" } ], "mass": 55293.0, "length": 488, "protein_name": "Calcium/calmodulin-dependent protein kinase type II subunit delta", "gene_name": "CAMK2D", "organism": "Bovine", "refseq_name": "calcium/calmodulin-dependent protein kinase type II subunit delta", "refseq_ac": [ { "id": "NP_001039798", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039798", "type": "external" } ], "gene_names_uniprotkb": "CAMK2D", "gene_names_refseq": "CAMK2D", "protein_names_uniprotkb": "Calcium/calmodulin-dependent protein kinase type II subunit delta; 2.7.11.17; CaM kinase II subunit delta; CaMK-II subunit delta", "protein_names_refseq": "caM kinase II subunit delta; caM-kinase II delta chain; caMK-II subunit delta; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase type II delta chain; calcium/calmodulin-dependent protein kinase type II subunit delta", "tax_id": 9913, "disease": "", "pathway": " (bta:532713); (R-BTA-3371571); (R-BTA-399719); (R-BTA-438066); (R-BTA-5576892); (R-BTA-5578775); (R-BTA-5673000); (R-BTA-5673001); (R-BTA-877300); (R-BTA-936837)", "pathway_count": 10, "publication_count": 1, "publication_id_list": "17923476", "class_list": "", "function": "CaMKIIdelta isoforms have similar effects on hypertrophic gene expression but disparate effects on Ca(2+) handling, [RefSeq, PubMed]; Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0014069 postsynaptic density;GO:0043005 neuron projection;GO:0042383 sarcolemma;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0060341 regulation of cellular localization;GO:0006468 protein phosphorylation;GO:1903076 regulation of protein localization to plasma membrane;GO:0048168 regulation of neuronal synaptic plasticity;GO:0010613 positive regulation of cardiac muscle hypertrophy", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2HJF7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ94-1", "uniprot_id": [ { "id": "RAD51_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ94", "type": "external" } ], "mass": 36982.0, "length": 339, "protein_name": "DNA repair protein RAD51 homolog 1", "gene_name": "RAD51", "organism": "Bovine", "refseq_name": "DNA repair protein RAD51 homolog 1", "refseq_ac": [ { "id": "NP_001039644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039644", "type": "external" } ], "gene_names_uniprotkb": "RAD51", "gene_names_refseq": "RAD51", "protein_names_uniprotkb": "DNA repair protein RAD51 homolog 1; 3.6.4.-", "protein_names_refseq": "DNA repair protein RAD51 homolog 1; RAD51 homolog (RecA homolog, E. coli)", "tax_id": 9913, "disease": "", "pathway": " (bta:514749); (R-BTA-5685938); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5693568); (R-BTA-5693579); (R-BTA-5693616); (R-BTA-912446)", "pathway_count": 8, "publication_count": 2, "publication_id_list": "22190703;23673140", "class_list": "", "function": "Homologous DNA recombinase that catalyzes strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA (ssDNA) in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. RAD51 targeting to ssDNA promotes removal of replication protein-A (RPA) from ssDNA and stabilization of RAD51-ssDNA filaments by blocking ATP hydrolysis. Nucleosomal DNA is peeled from the histone surface by the RAD51 filament. Recruited to resolve stalled replication forks during replication stress. Also required for homologous recombination during meiosis by acting as an non-catalytic accessory factor for DMC1 recombinase, enabling proper chromosome pairing and crossing over. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair., [UniProtKB, UniProtKB, UniProtKB]; Meiosis progression and female age affect expression profile of DNA repair RAD51 gene in bovine oocytes., [RefSeq, PubMed]; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; RAD51 plays a crucial role in halting cell death program induced by ionizing radiation in bovine oocytes. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006312 mitotic recombination;GO:0010833 telomere maintenance via telomere lengthening;GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination;GO:0071479 cellular response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2KJ94-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QE5-1", "uniprot_id": [ { "id": "CIB1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QE5", "type": "external" } ], "mass": 21728.0, "length": 191, "protein_name": "Calcium and integrin-binding protein 1", "gene_name": "CIB1", "organism": "Bovine", "refseq_name": "calcium and integrin-binding protein 1", "refseq_ac": [ { "id": "NP_001068901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068901", "type": "external" } ], "gene_names_uniprotkb": "CIB1", "gene_names_refseq": "CIB1", "protein_names_uniprotkb": "Calcium and integrin-binding protein 1; Calmyrin", "protein_names_refseq": "calcium and integrin-binding protein 1; calmyrin", "tax_id": 9913, "disease": "", "pathway": " (bta:510141)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Also promotes cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells (By similarity). Forms a complex with TMC6/EVER1 and TMC8/EVER2 in lymphocytes and keratynocytes where CIB1 stabilizes TMC6 and TMC8 levels and reciprocally (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0044325 transmembrane transporter binding;GO:0005509 calcium ion binding;GO:0031267 small GTPase binding;GO:0043495 protein-membrane adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005813 centrosome", "go_biological_process": "GO:0001525 angiogenesis;GO:0001934 positive regulation of protein phosphorylation;GO:0002931 response to ischemia;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q17QE5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2UVX4-1", "uniprot_id": [ { "id": "CO3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2UVX4", "type": "external" } ], "mass": 187253.0, "length": 1661, "protein_name": "Complement C3", "gene_name": "C3", "organism": "Bovine", "refseq_name": "complement C3 preproprotein", "refseq_ac": [ { "id": "NP_001035559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035559", "type": "external" } ], "gene_names_uniprotkb": "C3", "gene_names_refseq": "C3", "protein_names_uniprotkb": "Complement C3; C3adesArg; Complement C3b-alpha' chain", "protein_names_refseq": "complement C3 preproprotein; complement component 3", "tax_id": 9913, "disease": "", "pathway": " (bta:280677); (R-BTA-173736); (R-BTA-174577); (R-BTA-198933); (R-BTA-375276); (R-BTA-381426); (R-BTA-418594); (R-BTA-6798695); (R-BTA-8957275); (R-BTA-977606)", "pathway_count": 10, "publication_count": 5, "publication_id_list": "16831446;26495903;30573663;37217939;8390825", "class_list": "", "function": "Acts as a chemoattractant for neutrophils in chronic inflammation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Adipogenic hormone that stimulates triglyceride synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial triglyceride clearance. Appears to stimulate triglyceride synthesis via activation of the PLC, MAPK and AKT signaling pathways. Acts by binding to its receptor, C5AR2, activating G protein-coupled receptor signaling, promoting the phosphorylation, ARRB2-mediated internalization and endocytosis of C5AR2. In contrast to C3a anaphylatoxin peptide, does not show pro-inflammatory activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Mediator of local inflammatory process released following cleavage by C3 convertase. Acts by binding to its receptor, C3AR1, activating G protein-coupled receptor signaling, promoting the phosphorylation, ARRB2-mediated internalization and endocytosis of C3AR1. C3a anaphylatoxin stimulates the activation of immune cells such as mast cells and basophilic leukocytes to release inflammation agents, such as cytokines, chemokines and histamine, which promote inflammation development. Also acts as potent chemoattractant for the migration of macrophages and neutrophils to the inflamed tissues, resulting in neutralization of the inflammatory triggers by multiple ways, such as phagocytosis and generation of reactive oxidants., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Non-enzymatic component of C5 convertase. Generated following cleavage by C3 convertase, it covalently attaches to the surface of pathogens, where it acts as an opsonin that marks the surface of antigens for removal. Complement C3b binds covalently via its reactive thioester, to cell surface carbohydrates or immune aggregates. Together with complement C4b, it then recruits the serine protease complement C2b to form the C5 convertase, which cleaves and activate C5, the next component of the complement pathways. In the alternative complement pathway, recruits the serine protease CFB to form the C5 convertase that cleaves and activates C5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Precursor of non-enzymatic components of the classical, alternative, lectin and GZMK complement pathways, which consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The structure of bovine C3 clearly demonstrates that the main chain around the thioester undergoes a helical transition upon activation, a rearrangement that is proposed to be the basis for the high level of reactivity of the thioester group., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q2KIZ4", "ec_number_list": [], "go_molecular_function": "GO:0004866 endopeptidase inhibitor activity;GO:0048018 receptor ligand activity;GO:0003823 antigen binding;GO:0031715 C5L2 anaphylatoxin chemotactic receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0005601 classical-complement-pathway C3/C5 convertase complex;GO:0106139 symbiont cell surface", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0001934 positive regulation of protein phosphorylation;GO:0006631 fatty acid metabolic process;GO:0006954 inflammatory response;GO:0016322 neuron remodeling", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q2UVX4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0100000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0Z7W6-1", "uniprot_id": [ { "id": "TMX1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0Z7W6", "type": "external" } ], "mass": 31581.0, "length": 278, "protein_name": "Thioredoxin-related transmembrane protein 1", "gene_name": "TMX1", "organism": "Bovine", "refseq_name": "thioredoxin-related transmembrane protein 1 precursor", "refseq_ac": [ { "id": "NP_001068853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068853", "type": "external" } ], "gene_names_uniprotkb": "TMX1; TXNDC1", "gene_names_refseq": "TMX1; TXNDC1", "protein_names_uniprotkb": "Thioredoxin-related transmembrane protein 1; 5.3.4.1; Protein disulfide-isomerase TMX1; Thioredoxin domain-containing protein 1", "protein_names_refseq": "Trx-like protein; protein disulfide-isomerase TMX1; thioredoxin domain containing 1; thioredoxin domain-containing protein 1; thioredoxin-related transmembrane protein 1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:509037)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Thioredoxin domain-containing protein that participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Acts as a key inhibitor of the alternative triglyceride biosynthesis pathway by inhibiting the activity of TMEM68/DIESL at the endoplasmic reticulum, thereby restricting accumulation of triacylglycerol. The alternative triglyceride biosynthesis pathway mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids. Acts as a protein disulfide isomerase by catalyzing formation or reduction of disulfide bonds. Specifically mediates formation of disulfide bonds of transmembrane proteins at the endoplasmic reticulum membrane. Involved in endoplasmic reticulum-associated degradation (ERAD) via its protein disulfide isomerase activity by acting on folding-defective polypeptides at the endoplasmic reticulum membrane. Acts as a negative regulator of platelet aggregation following secretion in the extracellular space. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals. Regulates endoplasmic reticulum-mitochondria Ca(2+) flux., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A3KN45;A5D9C0", "ec_number_list": [], "go_molecular_function": "GO:0015036 disulfide oxidoreductase activity;GO:0004857 enzyme inhibitor activity;GO:0015035 protein-disulfide reductase activity;GO:0003756 protein disulfide isomerase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005730 nucleolus;GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0051924 regulation of calcium ion transport;GO:0034976 response to endoplasmic reticulum stress;GO:1904294 positive regulation of ERAD pathway;GO:0010868 negative regulation of triglyceride biosynthetic process;GO:0090331 negative regulation of platelet aggregation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0Z7W6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KHU5-1", "uniprot_id": [ { "id": "MACD1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KHU5", "type": "external" } ], "mass": 35569.0, "length": 325, "protein_name": "ADP-ribose glycohydrolase MACROD1", "gene_name": "MACROD1", "organism": "Bovine", "refseq_name": "ADP-ribose glycohydrolase MACROD1", "refseq_ac": [ { "id": "NP_001039974", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039974", "type": "external" } ], "gene_names_uniprotkb": "MACROD1; LRP16", "gene_names_refseq": "LRP16; MACROD1", "protein_names_uniprotkb": "ADP-ribose glycohydrolase MACROD1; 3.1.1.106; 3.2.2.-; MACRO domain-containing protein 1; O-acetyl-ADP-ribose deacetylase MACROD1; Protein LRP16; [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase MACROD1", "protein_names_refseq": "ADP-ribose glycohydrolase MACROD1; MACRO domain containing 1; MACRO domain-containing protein 1; O-acetyl-ADP-ribose deacetylase MACROD1; [Protein ADP-ribosylaspartate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase MACROD1; [Protein ADP-ribosylglutamate] hydrolase", "tax_id": 9913, "disease": "", "pathway": " (bta:613568)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Plays a role in estrogen signaling. Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen. May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation. Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction. Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells. Enhances ESR1-mediated transcription activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" }, { "id": "3.1.1.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.106", "type": "external" }, { "id": "3.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.19", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" } ], "go_molecular_function": "GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0061463 O-acetyl-ADP-ribose deacetylase activity;GO:0140293 ADP-ribosylglutamate hydrolase activity;GO:0019213 deacetylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006974 DNA damage response;GO:0051725 protein de-ADP-ribosylation;GO:0042278 purine nucleoside metabolic process;GO:0140291 peptidyl-glutamate ADP-deribosylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KHU5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMS4-1", "uniprot_id": [ { "id": "LRFN3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMS4", "type": "external" } ], "mass": 66260.0, "length": 628, "protein_name": "Leucine-rich repeat and fibronectin type-III domain-containing protein 3", "gene_name": "LRFN3", "organism": "Bovine", "refseq_name": "leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor", "refseq_ac": [ { "id": "NP_001070427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070427", "type": "external" } ], "gene_names_uniprotkb": "LRFN3; SALM4", "gene_names_refseq": "LRFN3", "protein_names_uniprotkb": "Leucine-rich repeat and fibronectin type-III domain-containing protein 3; Synaptic adhesion-like molecule 4", "protein_names_refseq": "leucine-rich repeat and fibronectin type-III domain-containing protein 3 precursor; leucine-rich repeat and fibronectin type-III domain-containing protein 3; synaptic adhesion-like molecule 4", "tax_id": 9913, "disease": "", "pathway": " (bta:767839); (R-BTA-8849932)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0048787 presynaptic active zone membrane;GO:0009986 cell surface;GO:0030424 axon;GO:0030425 dendrite;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMS4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIA5-1", "uniprot_id": [ { "id": "DNM1L_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIA5", "type": "external" } ], "mass": 83352.0, "length": 749, "protein_name": "Dynamin-1-like protein", "gene_name": "DNM1L", "organism": "Bovine", "refseq_name": "dynamin-1-like protein", "refseq_ac": [ { "id": "NP_001039959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039959", "type": "external" } ], "gene_names_uniprotkb": "DNM1L", "gene_names_refseq": "DNM1L", "protein_names_uniprotkb": "Dynamin-1-like protein; 3.6.5.5", "protein_names_refseq": "dynamin-1-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:540892); (R-BTA-75153)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. The specific recruitment at scission sites is mediated by membrane receptors like MFF, MIEF1 and MIEF2 for mitochondrial membranes. While the recruitment by the membrane receptors is GTP-dependent, the following hydrolysis of GTP induces the dissociation from the receptors and allows DNM1L filaments to curl into closed rings that are probably sufficient to sever a double membrane. Acts downstream of PINK1 to promote mitochondrial fission in a PRKN-dependent manner. Plays an important role in mitochondrial fission during mitosis (By similarity). Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage (By similarity). Required for normal brain development, including that of cerebellum (By similarity). Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues (By similarity). Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution. Rhythmic control of its activity following phosphorylation at Ser-650 is essential for the circadian control of mitochondrial ATP production (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0099073 mitochondrion-derived vesicle;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome", "go_biological_process": "GO:0090149 mitochondrial membrane fission;GO:1900063 regulation of peroxisome organization;GO:0006897 endocytosis;GO:0016559 peroxisome fission;GO:0051259 protein complex oligomerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIA5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28132-1", "uniprot_id": [ { "id": "SCF_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28132", "type": "external" } ], "mass": 31015.0, "length": 274, "protein_name": "Kit ligand", "gene_name": "KITLG", "organism": "Bovine", "refseq_name": "kit ligand precursor", "refseq_ac": [ { "id": "NP_776800", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776800", "type": "external" } ], "gene_names_uniprotkb": "KITLG; SCF", "gene_names_refseq": "KITLG; MGF", "protein_names_uniprotkb": "Kit ligand; MGF; Mast cell growth factor; SCF; Stem cell factor; c-Kit ligand", "protein_names_refseq": "C-kit ligand; SCF; kit ligand precursor; mast cell growth factor (white heifer disease); stem cell factor", "tax_id": 9913, "disease": "", "pathway": " (bta:281885); (R-BTA-1257604); (R-BTA-1433557); (R-BTA-1433559); (R-BTA-5673001); (R-BTA-6811558); (R-BTA-9856649)", "pathway_count": 7, "publication_count": 3, "publication_id_list": "10384045;18386286;7520283", "class_list": "", "function": "FGF7 may be an important regulator for oocyte growth and its action is mediated via the KIT/KITLG signaling pathway., [RefSeq, PubMed]; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Also mediates cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q9TU74", "ec_number_list": [], "go_molecular_function": "GO:0005173 stem cell factor receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0003006 developmental process involved in reproduction;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0045636 positive regulation of melanocyte differentiation;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q28132-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81282-1", "uniprot_id": [ { "id": "CSPG2_BOVIN", "url": "https://www.uniprot.org/uniprot/P81282", "type": "external" } ], "mass": 369990.0, "length": 3381, "protein_name": "Versican core protein", "gene_name": "VCAN", "organism": "Bovine", "refseq_name": "versican core protein precursor", "refseq_ac": [ { "id": "NP_851378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_851378", "type": "external" } ], "gene_names_uniprotkb": "VCAN; CSPG2", "gene_names_refseq": "CSPG2; VCAN", "protein_names_uniprotkb": "Versican core protein; Chondroitin sulfate proteoglycan 2; Chondroitin sulfate proteoglycan core protein 2; GHAP; Glial hyaluronate-binding protein; Large fibroblast proteoglycan; PG-M", "protein_names_refseq": "GHAP; PG-M; chondroitin sulfate proteoglycan 2 (versican); chondroitin sulfate proteoglycan core protein 2; glial hyaluronate-binding protein; large fibroblast proteoglycan; versican core protein precursor; versican core protein", "tax_id": 9913, "disease": "", "pathway": " (bta:282662); (R-BTA-1971475); (R-BTA-2022870); (R-BTA-2022923); (R-BTA-2024101); (R-BTA-3000178); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 8, "publication_count": 4, "publication_id_list": "1720020;20386503;21289569;9624174", "class_list": "", "function": "Data show that biglycan, collagen type I, collagen type II, decorin, and versican were significantly affected by vibration duration, frequency, and amplitude., [RefSeq, PubMed]; Data show that expression of mRNAs for aggrecan, collagen type II, and versican were significantly effected by the intervention., [RefSeq, PubMed]; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 40, "predicted_n_glycosites": 24, "predicted_o_glycosites": 16, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 40, "binding_glycan_count": 0, "secondary_ac_list": "O77609;O77610;O77611;O77612", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding;GO:0008160 protein tyrosine phosphatase activator activity", "go_cellular_component": "GO:0033165 interphotoreceptor matrix;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0045202 synapse;GO:0001750 photoreceptor outer segment", "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development;GO:0048731 system development", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P81282-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DA1-1", "uniprot_id": [ { "id": "AT1A1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DA1", "type": "external" } ], "mass": 112643.0, "length": 1021, "protein_name": "Sodium/potassium-transporting ATPase subunit alpha-1", "gene_name": "ATP1A1", "organism": "Bovine", "refseq_name": "sodium/potassium-transporting ATPase subunit alpha-1", "refseq_ac": [ { "id": "NP_001070266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070266", "type": "external" } ], "gene_names_uniprotkb": "ATP1A1", "gene_names_refseq": "ATP1A1", "protein_names_uniprotkb": "Sodium/potassium-transporting ATPase subunit alpha-1; 7.2.2.13; Na(+)/K(+) ATPase alpha-1 subunit; Sodium pump subunit alpha-1", "protein_names_refseq": "ATPase, Na+/K+ transporting, alpha 1 polypeptide; Na(+)/K(+) ATPase alpha-1 subunit; sodium pump subunit alpha-1; sodium/potassium-transporting ATPase subunit alpha-1", "tax_id": 9913, "disease": "", "pathway": " (bta:282144); (R-BTA-5578775); (R-BTA-936837)", "pathway_count": 3, "publication_count": 7, "publication_id_list": "12169672;12657675;20336380;20467982;22535401;25967398;27050261", "class_list": "", "function": "ATP1A1 gene polymorphism has a role in heat tolerance traits in dairy cattle Publication Status: Online-Only, [RefSeq, PubMed]; Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (By similarity). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Suggest ATP1A1 has a central role in the osmoregulatory response of nucleus pulposus cells., [RefSeq, PubMed]; The ATP1A1 gene polymorphism has potential as a marker for mastitis resistance in dairy cattle. Publication Status: Online-Only, [RefSeq, PubMed]; The polymorphisms within the coding region of bovine ATP1A1 gene, were analyzed., [RefSeq, PubMed]; This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.13", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005391 P-type sodium:potassium-exchanging transporter activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0030424 axon;GO:0045121 membrane raft;GO:0042470 melanosome", "go_biological_process": "GO:0002028 regulation of sodium ion transport;GO:0006883 intracellular sodium ion homeostasis;GO:0030007 intracellular potassium ion homeostasis;GO:0036376 sodium ion export across plasma membrane;GO:1990573 potassium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q08DA1-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QB3-1", "uniprot_id": [ { "id": "ASAH1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QB3", "type": "external" } ], "mass": 44965.0, "length": 395, "protein_name": "Acid ceramidase", "gene_name": "ASAH1", "organism": "Bovine", "refseq_name": "acid ceramidase precursor", "refseq_ac": [ { "id": "NP_001068927", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068927", "type": "external" } ], "gene_names_uniprotkb": "ASAH1", "gene_names_refseq": "ASAH1", "protein_names_uniprotkb": "Acid ceramidase; 3.5.1.-; 3.5.1.23; ACDase; AC; Acid CDase; Acylsphingosine deacylase; N-acylethanolamine hydrolase ASAH1; N-acylsphingosine amidohydrolase", "protein_names_refseq": "ACDase; AC; N-acylethanolamine hydrolase ASAH1; acid CDase; acid ceramidase precursor; acid ceramidase; acylsphingosine deacylase", "tax_id": 9913, "disease": "", "pathway": " (bta:510620); (R-BTA-6798695); (R-BTA-9840310)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatty acids and sphingosine (By similarity). For the reverse synthetic reaction, the natural sphingosine D-erythro isomer is more efficiently utilized as a substrate compared to D-erythro-dihydrosphingosine and D-erythro-phytosphingosine, while the fatty acids with chain lengths of 12 or 14 carbons are the most efficiently used (By similarity). Also has an N-acylethanolamine hydrolase activity (By similarity). By regulating the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes (By similarity). Also indirectly regulates tumor necrosis factor/TNF-induced apoptosis (By similarity). By regulating the intracellular balance between ceramides and sphingosine, in adrenocortical cells, probably also acts as a regulator of steroidogenesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "3.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.60", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0017064 fatty acid amide hydrolase activity;GO:0017040 N-acylsphingosine amidohydrolase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0016020 membrane;GO:0005764 lysosome;GO:0005576 extracellular region", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0046513 ceramide biosynthetic process;GO:0046512 sphingosine biosynthetic process;GO:0046514 ceramide catabolic process;GO:0030216 keratinocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q17QB3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMT1-1", "uniprot_id": [ { "id": "ERCC3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMT1", "type": "external" } ], "mass": 89193.0, "length": 782, "protein_name": "General transcription and DNA repair factor IIH helicase/translocase subunit XPB", "gene_name": "ERCC3", "organism": "Bovine", "refseq_name": "general transcription and DNA repair factor IIH helicase/translocase subunit XPB", "refseq_ac": [ { "id": "NP_001039453", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039453", "type": "external" } ], "gene_names_uniprotkb": "ERCC3", "gene_names_refseq": "ERCC3", "protein_names_uniprotkb": "General transcription and DNA repair factor IIH helicase/translocase subunit XPB; 5.6.2.4; DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; TFIIH subunit XPB", "protein_names_refseq": "DNA 3'-5' helicase/translocase XPB; DNA excision repair protein ERCC-3; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH subunit XPB; excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing); general transcription and DNA repair factor IIH helicase subunit XPB; general transcription and DNA repair factor IIH helicase/translocase subunit XPB", "tax_id": 9913, "disease": "", "pathway": " (bta:507984); (R-BTA-113418); (R-BTA-5696395); (R-BTA-5696400); (R-BTA-674695); (R-BTA-6781823); (R-BTA-6782135); (R-BTA-6782210); (R-BTA-6796648); (R-BTA-72086); (R-BTA-73762); (R-BTA-73772); (R-BTA-73776); (R-BTA-73779); (R-BTA-73863); (R-BTA-75953); (R-BTA-75955); (R-BTA-76042); (R-BTA-77075)", "pathway_count": 19, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-dependent 3'-5' DNA helicase/translocase; binds dsDNA rather than ssDNA, unzipping it in a translocase rather than classical helicase activity. Component of the general transcription and DNA repair factor IIH (TFIIH) core complex. When complexed to CDK-activating kinase (CAK), involved in RNA transcription by RNA polymerase II. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening; it may wrap around the damaged DNA wedging it open, causing localized melting and twisting that allows XPD/ERCC2 helicase to anchor. The ATP-dependent helicase activity of XPB/ERCC3 may be required for promoter escape. Also involved in transcription-coupled nucleotide excision repair (NER) of damaged DNA. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The structure of the TFIIH transcription complex differs from the NER-TFIIH complex; large movements by XPD/ERCC2 and XPB/ERCC3 are stabilized by XPA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.1.1.56", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.56", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005675 transcription factor TFIIH holo complex;GO:0005669 transcription factor TFIID complex;GO:0000112 nucleotide-excision repair factor 3 complex;GO:0000439 transcription factor TFIIH core complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006979 response to oxidative stress;GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process;GO:0009411 response to UV", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMT1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RK2-1", "uniprot_id": [ { "id": "PYC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RK2", "type": "external" } ], "mass": 129698.0, "length": 1178, "protein_name": "Pyruvate carboxylase, mitochondrial", "gene_name": "PC", "organism": "Bovine", "refseq_name": "pyruvate carboxylase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_808815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_808815", "type": "external" } ], "gene_names_uniprotkb": "PC", "gene_names_refseq": "PC", "protein_names_uniprotkb": "Pyruvate carboxylase, mitochondrial; 6.4.1.1; PCB; Pyruvic carboxylase", "protein_names_refseq": "PCB; pyruvate carboxylase, mitochondrial precursor; pyruvate carboxylase, mitochondrial; pyruvic carboxylase", "tax_id": 9913, "disease": "", "pathway": " (bta:338471); (R-BTA-196780); (R-BTA-70263); (R-BTA-70268)", "pathway_count": 4, "publication_count": 4, "publication_id_list": "15248600;16027208;21297057;22859760", "class_list": "", "function": "Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Expression of pyruvate carboxylase mRNA is part of the adaptive response to feed intake restriction, [RefSeq, PubMed]; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data indicate that pyruvate carboxylase promoter 1 is activated by fatty acids found in serum of feed-restricted cows., [RefSeq, PubMed]; These data indicate that response of bovine PC gene to thermal stress is through promoter regulation and suggest that there are unique characteristics of bovine PC promoters that may contribute to the physiological response to thermal stress., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q866R1", "ec_number_list": [ { "id": "6.4.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.4", "type": "external" }, { "id": "6.4.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.3", "type": "external" }, { "id": "6.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0009374 biotin binding;GO:0004736 pyruvate carboxylase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005829 cytosol", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006094 gluconeogenesis;GO:0006739 NADP+ metabolic process;GO:0019074 viral RNA genome packaging;GO:0010629 negative regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q29RK2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QQ3-1", "uniprot_id": [ { "id": "SNP25_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QQ3", "type": "external" } ], "mass": 23315.0, "length": 206, "protein_name": "Synaptosomal-associated protein 25", "gene_name": "SNAP25", "organism": "Bovine", "refseq_name": "synaptosomal-associated protein 25", "refseq_ac": [ { "id": "NP_001069714", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069714", "type": "external" } ], "gene_names_uniprotkb": "SNAP25", "gene_names_refseq": "SNAP-25; SNAP25", "protein_names_uniprotkb": "Synaptosomal-associated protein 25; SNAP-25; Synaptosomal-associated 25 kDa protein", "protein_names_refseq": "synaptosomal-associated 25 kDa protein; synaptosomal-associated protein 25; synaptosomal-associated protein, 25kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:540853); (R-BTA-181429); (R-BTA-181430); (R-BTA-210500); (R-BTA-212676); (R-BTA-264642); (R-BTA-449836); (R-BTA-6798695); (R-BTA-888590)", "pathway_count": 9, "publication_count": 6, "publication_id_list": "14551199;17112584;19546860;23220175;23940346;8611567", "class_list": "", "function": "Dynamic experiments using TIRFM revealed that attenuation of cortical F-actin movement clearly diminishes the mobility of SNAP-25 clusters., [RefSeq, PubMed]; In individual chromaffin cells, we tracked conformational changes in SNAP25 by total internal reflection fluorescence resonance energy transfer (FRET) microscopy while exocytotic catecholamine release from single vesicles was simultaneously recorded, [RefSeq, PubMed]; Microdomains carrying syntaxin1/SNAP-25 and different types of calcium channels act as the sites for physiological granule fusion in 'in situ' chromaffin cells, [RefSeq, PubMed]; Stable syntaxin/SNAP-25 dimers are a central principle of the SNARE assembly pathway underlying regulated exocytosis., [RefSeq, PubMed]; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005484 SNAP receptor activity;GO:0017075 syntaxin-1 binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030426 growth cone", "go_biological_process": "GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0016082 synaptic vesicle priming;GO:0010975 regulation of neuron projection development;GO:0006906 vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q17QQ3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1KZG0-1", "uniprot_id": [ { "id": "S39A4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1KZG0", "type": "external" } ], "mass": 68620.0, "length": 653, "protein_name": "Zinc transporter ZIP4", "gene_name": "SLC39A4", "organism": "Bovine", "refseq_name": "zinc transporter ZIP4 precursor", "refseq_ac": [ { "id": "NP_001039532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039532", "type": "external" } ], "gene_names_uniprotkb": "SLC39A4; ZIP4", "gene_names_refseq": "SLC39A4", "protein_names_uniprotkb": "Zinc transporter ZIP4; Solute carrier family 39 member 4; ZIP-4; Zrt- and Irt-like protein 4", "protein_names_refseq": "ZIP-4; solute carrier family 39 (zinc transporter), member 4; zinc transporter ZIP4 precursor; zinc transporter ZIP4; zrt- and Irt-like protein 4", "tax_id": 9913, "disease": "", "pathway": " (bta:510951); (R-BTA-442380)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16714095", "class_list": "", "function": "Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability. Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q1KZF9", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0106219 zinc ion sensor activity;GO:0140410 monoatomic cation:bicarbonate symporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006882 intracellular zinc ion homeostasis;GO:0030003 intracellular monoatomic cation homeostasis;GO:0071578 zinc ion import across plasma membrane;GO:0006829 zinc ion transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1KZG0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIG5-1", "uniprot_id": [ { "id": "PFKAM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIG5", "type": "external" } ], "mass": 85294.0, "length": 779, "protein_name": "ATP-dependent 6-phosphofructokinase, muscle type", "gene_name": "PFKM", "organism": "Bovine", "refseq_name": "ATP-dependent 6-phosphofructokinase, muscle type", "refseq_ac": [ { "id": "NP_001068736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068736", "type": "external" } ], "gene_names_uniprotkb": "PFKM", "gene_names_refseq": "ATP-PFK; PFK-M; PFKM", "protein_names_uniprotkb": "ATP-dependent 6-phosphofructokinase, muscle type; 2.7.1.11; 6-phosphofructokinase type A; ATP-PFK; PFK-A; PFK-M; Phosphofructo-1-kinase isozyme A; Phosphohexokinase", "protein_names_refseq": "6-phosphofructokinase type A; 6-phosphofructokinase, muscle type; ATP-dependent 6-phosphofructokinase, muscle type; PFK-A; phosphofructo-1-kinase isozyme A; phosphofructokinase 1; phosphofructokinase-M; phosphohexokinase", "tax_id": 9913, "disease": "", "pathway": " (bta:506544); (R-BTA-70171)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" } ], "go_molecular_function": "GO:0070095 fructose-6-phosphate binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0003872 6-phosphofructokinase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005945 6-phosphofructokinase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0030388 fructose 1,6-bisphosphate metabolic process;GO:0061621 canonical glycolysis;GO:0006002 fructose 6-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIG5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28156-1", "uniprot_id": [ { "id": "PDE5A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28156", "type": "external" } ], "mass": 98627.0, "length": 865, "protein_name": "cGMP-specific 3',5'-cyclic phosphodiesterase", "gene_name": "PDE5A", "organism": "Bovine", "refseq_name": "cGMP-specific 3',5'-cyclic phosphodiesterase", "refseq_ac": [ { "id": "NP_776842", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776842", "type": "external" } ], "gene_names_uniprotkb": "PDE5A; PDE5", "gene_names_refseq": "PDE5A", "protein_names_uniprotkb": "cGMP-specific 3',5'-cyclic phosphodiesterase; 3.1.4.35; CGB-PDE; cGMP-binding cGMP-specific phosphodiesterase", "protein_names_refseq": "CGB-PDE; cGMP-binding cGMP-specific phosphodiesterase; cGMP-specific 3',5'-cyclic phosphodiesterase; phosphodiesterase 5A, cGMP-specific", "tax_id": 9913, "disease": "", "pathway": " (bta:281972); (R-BTA-418457); (R-BTA-445355); (R-BTA-9013422)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "14662775;8077192;8226796;8530505;8703039;9445376", "class_list": "", "function": "Ectopic expression of bovine phosphodiesterase 5 in Drosophila has shown that it has a critical role in Malpighian (renal) tubule function in vivo and that function is conserved across evolution, [RefSeq, PubMed]; Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:8530505). Specifically regulates nitric-oxide-generated cGMP (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.4.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030553 cGMP binding;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity;GO:0004112 cyclic-nucleotide phosphodiesterase activity;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity", "go_cellular_component": "", "go_biological_process": "GO:0007165 signal transduction;GO:0046069 cGMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q28156-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81134-1", "uniprot_id": [ { "id": "RENR_BOVIN", "url": "https://www.uniprot.org/uniprot/P81134", "type": "external" } ], "mass": 39491.0, "length": 351, "protein_name": "Renin receptor", "gene_name": "ATP6AP2", "organism": "Bovine", "refseq_name": "renin receptor precursor", "refseq_ac": [ { "id": "NP_001091491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091491", "type": "external" } ], "gene_names_uniprotkb": "ATP6AP2; ATP6IP2", "gene_names_refseq": "ATP6AP2", "protein_names_uniprotkb": "Renin receptor; ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; Renin/prorenin receptor; V-ATPase M8.9 subunit; Vacuolar ATP synthase membrane sector-associated protein M8-9", "protein_names_refseq": "ATPase H(+)-transporting lysosomal accessory protein 2; ATPase H(+)-transporting lysosomal-interacting protein 2; ATPase, H+ transporting, lysosomal accessory protein 2; V-ATPase M8.9 subunit; renin receptor precursor; renin receptor; renin/prorenin receptor; vacuolar ATP synthase membrane sector-associated protein M8-9", "tax_id": 9913, "disease": "", "pathway": " (bta:513520); (R-BTA-2022377); (R-BTA-6798695)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "27060674;32764564;9556572", "class_list": "", "function": "Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system (By similarity). May mediate renin-dependent cellular responses by activating ERK1 and ERK2 (By similarity). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (By similarity). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This is the first study to identify the (pro)renin receptor in ovarian cells and to demonstrate the independent role of prorenin in the resumption of oocyte meiosis in cattle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D7N4", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0030424 axon;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0007042 lysosomal lumen acidification;GO:0030177 positive regulation of Wnt signaling pathway;GO:0045851 pH reduction;GO:1902600 proton transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P81134-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KHV7-1", "uniprot_id": [ { "id": "UBP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KHV7", "type": "external" } ], "mass": 68101.0, "length": 606, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 2", "gene_name": "USP2", "organism": "Bovine", "refseq_name": "ubiquitin carboxyl-terminal hydrolase 2", "refseq_ac": [ { "id": "NP_001039728", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039728", "type": "external" } ], "gene_names_uniprotkb": "USP2; UBP41", "gene_names_refseq": "USP2", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 2; 3.4.19.12; 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2", "protein_names_refseq": "41 kDa ubiquitin-specific protease; deubiquitinating enzyme 2; ubiquitin carboxyl-terminal hydrolase 2; ubiquitin thioesterase 2; ubiquitin thiolesterase 2; ubiquitin-specific-processing protease 2", "tax_id": 9913, "disease": "", "pathway": " (bta:522980); (R-BTA-5357786); (R-BTA-5357905); (R-BTA-5357956)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes., [UniProtKB, UniProtKB, UniProtKB]; Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and BMAL1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006508 proteolysis;GO:0016579 protein deubiquitination;GO:0045931 positive regulation of mitotic cell cycle;GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KHV7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIL1-1", "uniprot_id": [ { "id": "MICU1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIL1", "type": "external" } ], "mass": 54422.0, "length": 478, "protein_name": "Calcium uptake protein 1, mitochondrial", "gene_name": "MICU1", "organism": "Bovine", "refseq_name": "calcium uptake protein 1, mitochondrial", "refseq_ac": [ { "id": "NP_001068806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068806", "type": "external" } ], "gene_names_uniprotkb": "MICU1; CBARA1", "gene_names_refseq": "CBARA1; MICU1", "protein_names_uniprotkb": "Calcium uptake protein 1, mitochondrial; Calcium-binding atopy-related autoantigen 1 homolog", "protein_names_refseq": "calcium binding atopy-related autoantigen 1; calcium uptake protein 1, mitochondrial; calcium-binding atopy-related autoantigen 1 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:507899); (R-BTA-8949215); (R-BTA-8949664)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains. MICU1 and MICU2 (or MICU3) form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake. At higher calcium levels, calcium-binding to MICU1 and MICU2 (or MICU3) induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel. Also required to protect against manganese toxicity by preventing manganese uptake by MCU: mechanistically, manganese-binding to its EF-hand domains does not induce any conformational change, maintaining MCU pore occlusion. Acts as a regulator of mitochondrial cristae structure independently of its ability to regulate the mitochondrial calcium uniporter channel. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity;GO:0042802 identical protein binding;GO:0019855 calcium channel inhibitor activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0031966 mitochondrial membrane;GO:0034704 calcium channel complex;GO:1990246 uniplex complex", "go_biological_process": "GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis;GO:1903852 positive regulation of cristae formation;GO:0051561 positive regulation of mitochondrial calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIL1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIJ0-1", "uniprot_id": [ { "id": "NAA50_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIJ0", "type": "external" } ], "mass": 19398.0, "length": 169, "protein_name": "N-alpha-acetyltransferase 50", "gene_name": "NAA50", "organism": "Bovine", "refseq_name": "N-alpha-acetyltransferase 50", "refseq_ac": [ { "id": "NP_001069218", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069218", "type": "external" } ], "gene_names_uniprotkb": "NAA50; NAT13", "gene_names_refseq": "NAA50; NAT13", "protein_names_uniprotkb": "N-alpha-acetyltransferase 50; 2.3.1.-; 2.3.1.258; N-acetyltransferase 13; N-epsilon-acetyltransferase 50; NatE catalytic subunit", "protein_names_refseq": "N-acetyltransferase 13 (GCN5-related); N-alpha-acetyltransferase 50; N-epsilon-acetyltransferase 50; natE catalytic subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:517211)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine (By similarity). Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position (By similarity). Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins (By similarity). Autoacetylates in vivo (By similarity). The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo (By similarity). Component of N-alpha-acetyltransferase complexes containing NAA10 and NAA15, which has N-alpha-acetyltransferase activity (By similarity). Does not influence the acetyltransferase activity of NAA10 (By similarity). However, it negatively regulates the N-alpha-acetyltransferase activity of the N-terminal acetyltransferase A complex (also called the NatA complex) (By similarity). The multiprotein complexes probably constitute the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides (By similarity). Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.256", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.256", "type": "external" }, { "id": "2.3.1.258", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.258", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031415 NatA complex;GO:0005730 nucleolus", "go_biological_process": "GO:0071962 mitotic sister chromatid cohesion, centromeric;GO:0034087 establishment of mitotic sister chromatid cohesion;GO:0007064 mitotic sister chromatid cohesion;GO:0006474 N-terminal protein amino acid acetylation;GO:0043687 post-translational protein modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIJ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E02-1", "uniprot_id": [ { "id": "NR1D1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E02", "type": "external" } ], "mass": 66785.0, "length": 613, "protein_name": "Nuclear receptor subfamily 1 group D member 1", "gene_name": "NR1D1", "organism": "Bovine", "refseq_name": "nuclear receptor subfamily 1 group D member 1", "refseq_ac": [ { "id": "NP_001071568", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071568", "type": "external" } ], "gene_names_uniprotkb": "NR1D1", "gene_names_refseq": "NR1D1", "protein_names_uniprotkb": "Nuclear receptor subfamily 1 group D member 1; EAR-1; Rev-erbA-alpha; V-erbA-related protein 1", "protein_names_refseq": "V-erbA-related protein 1; V-erbA-related protein EAR-1; nuclear receptor subfamily 1 group D member 1; rev-erbA-alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:768225); (R-BTA-383280)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "15190009;17075855;25007867", "class_list": "", "function": "Results indicate that nuclear receptor subfamily 1 group D member 1(REV-ERBalpha) plays an inhibitory role in the expression of prostaglandin G/H synthetase(PTGS2) in both bovine uterine stromal and epithelial cells treated with ovarian steroids, [RefSeq, PubMed]; Rev-ErbAalpha is highly expressed in articular chondrocytes, [RefSeq, PubMed]; This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes. [provided by RefSeq, Feb 2014]., [RefSeq]; Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that governs circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock components BMAL1, CLOCK and CRY1. Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression. Recognizes two classes of DNA response elements within the promoter of its target genes and can bind to DNA as either monomers or homodimers, depending on the nature of the response element. Binds as a monomer to a response element composed of the consensus half-site motif 5'-[A/G]GGTCA-3' preceded by an A/T-rich 5' sequence (RevRE), or as a homodimer to a direct repeat of the core motif spaced by two nucleotides (RevDR-2). Acts as a potent competitive repressor of ROR alpha (RORA) function and regulates the levels of its ligand heme by repressing the expression of PPARGC1A, a potent inducer of heme synthesis. Regulates lipid metabolism by repressing the expression of APOC3 and by influencing the activity of sterol response element binding proteins (SREBPs); represses INSIG2 which interferes with the proteolytic activation of SREBPs which in turn govern the rhythmic expression of enzymes with key functions in sterol and fatty acid synthesis. Regulates gluconeogenesis via repression of G6PC1 and PEPCK and adipocyte differentiation via repression of PPARG. Regulates glucagon release in pancreatic alpha-cells via the AMPK-NAMPT-SIRT1 pathway and the proliferation, glucose-induced insulin secretion and expression of key lipogenic genes in pancreatic-beta cells. Positively regulates bile acid synthesis by increasing hepatic expression of CYP7A1 via repression of NR0B2 and NFIL3 which are negative regulators of CYP7A1. Modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy; controls mitochondrial biogenesis and respiration by interfering with the STK11-PRKAA1/2-SIRT1-PPARGC1A signaling pathway. Represses the expression of SERPINE1/PAI1, an important modulator of cardiovascular disease and the expression of inflammatory cytokines and chemokines in macrophages. Represses gene expression at a distance in macrophages by inhibiting the transcription of enhancer-derived RNAs (eRNAs). Plays a role in the circadian regulation of body temperature and negatively regulates thermogenic transcriptional programs in brown adipose tissue (BAT); imposes a circadian oscillation in BAT activity, increasing body temperature when awake and depressing thermogenesis during sleep. In concert with NR2E3, regulates transcriptional networks critical for photoreceptor development and function. In addition to its activity as a repressor, can also act as a transcriptional activator. In the ovarian granulosa cells acts as a transcriptional activator of STAR which plays a role in steroid biosynthesis. In collaboration with SP1, activates GJA1 transcription in a heme-independent manner (By similarity). Represses the transcription of CYP2B10, CYP4A10 and CYP4A14 (By similarity). Represses the transcription of CES2 (By similarity). Represses and regulates the circadian expression of TSHB in a NCOR1-dependent manner (By similarity). Negatively regulates the protein stability of NR3C1 and influences the time-dependent subcellular distribution of NR3C1, thereby affecting its transcriptional regulatory activity (By similarity). Plays a critical role in the circadian control of neutrophilic inflammation in the lung; under resting, non-stress conditions, acts as a rhythmic repressor to limit inflammatory activity whereas in the presence of inflammatory triggers undergoes ubiquitin-mediated degradation thereby relieving inhibition of the inflammatory response (By similarity). Plays a key role in the circadian regulation of microglial activation and neuroinflammation; suppresses microglial activation through the NF-kappaB pathway in the central nervous system (By similarity). Plays a role in the regulation of the diurnal rhythms of lipid and protein metabolism in the skeletal muscle via transcriptional repression of genes controlling lipid and amino acid metabolism in the muscle (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity;GO:0070888 E-box binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0030425 dendrite;GO:0043197 dendritic spine;GO:0016604 nuclear body", "go_biological_process": "GO:1903979 negative regulation of microglial cell activation;GO:0060086 circadian temperature homeostasis;GO:0070859 positive regulation of bile acid biosynthetic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q08E02-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DM1-1", "uniprot_id": [ { "id": "DEMA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DM1", "type": "external" } ], "mass": 45548.0, "length": 406, "protein_name": "Dematin", "gene_name": "DMTN", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DMTN; DMT; EPB49", "gene_names_refseq": "", "protein_names_uniprotkb": "Dematin; Dematin actin-binding protein; Erythrocyte membrane protein band 4.9", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5223345)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Membrane-cytoskeleton-associated protein with F-actin-binding activity that induces F-actin bundles formation and stabilization. Its F-actin-bundling activity is reversibly regulated upon its phosphorylation by the cAMP-dependent protein kinase A (PKA). Binds to the erythrocyte membrane glucose transporter-1 SLC2A1/GLUT1, and hence stabilizes and attaches the spectrin-actin network to the erythrocytic plasma membrane. Plays a role in maintaining the functional integrity of PKA-activated erythrocyte shape and the membrane mechanical properties. Also plays a role as a modulator of actin dynamics in fibroblasts; acts as a negative regulator of the RhoA activation pathway. In platelets, functions as a regulator of internal calcium mobilization across the dense tubular system that affects platelet granule secretion pathways and aggregation. Also required for the formation of a diverse set of cell protrusions, such as filopodia and lamellipodia, necessary for platelet cell spreading, motility and migration. Acts as a tumor suppressor and inhibits malignant cell transformation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 19, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0051015 actin filament binding;GO:0030507 spectrin binding", "go_cellular_component": "GO:0005790 smooth endoplasmic reticulum;GO:0005829 cytosol;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0071786 endoplasmic reticulum tubular network organization;GO:0032956 regulation of actin cytoskeleton organization;GO:0051563 smooth endoplasmic reticulum calcium ion homeostasis;GO:0071320 cellular response to cAMP;GO:0030036 actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DM1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC89-1", "uniprot_id": [ { "id": "ZDH20_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC89", "type": "external" } ], "mass": 41907.0, "length": 365, "protein_name": "Palmitoyltransferase ZDHHC20", "gene_name": "ZDHHC20", "organism": "Bovine", "refseq_name": "palmitoyltransferase ZDHHC20", "refseq_ac": [ { "id": "NP_001069856", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069856", "type": "external" } ], "gene_names_uniprotkb": "ZDHHC20", "gene_names_refseq": "ZDHHC20", "protein_names_uniprotkb": "Palmitoyltransferase ZDHHC20; 2.3.1.-; 2.3.1.225; Acyltransferase ZDHHC20; Zinc finger DHHC domain-containing protein 20", "protein_names_refseq": "DHHC-20; acyltransferase ZDHHC20; palmitoyltransferase ZDHHC20; probable palmitoyltransferase ZDHHC20; zinc finger DHHC domain-containing protein 20; zinc finger DHHC-type containing 20", "tax_id": 9913, "disease": "", "pathway": " (bta:615659)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains. May palmitoylate CALHM1 subunit of gustatory voltage-gated ion channels and modulate channel gating and kinetics. Palmitoylates TRIM28 and thereby plays an important role in the DNA damage repair response., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.225", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.225", "type": "external" }, { "id": "6.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.1.2", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019706 protein-cysteine S-palmitoyltransferase activity;GO:0016409 palmitoyltransferase activity;GO:0019705 protein-cysteine S-myristoyltransferase activity;GO:0140439 protein-cysteine S-stearoyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006612 protein targeting to membrane;GO:0006974 DNA damage response;GO:0018345 protein palmitoylation;GO:0018230 peptidyl-L-cysteine S-palmitoylation;GO:0016188 synaptic vesicle maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC89-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCN6-1", "uniprot_id": [ { "id": "CSTN3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCN6", "type": "external" } ], "mass": 105795.0, "length": 957, "protein_name": "Calsyntenin-3", "gene_name": "CLSTN3", "organism": "Bovine", "refseq_name": "calsyntenin-3 precursor", "refseq_ac": [ { "id": "NP_001068893", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068893", "type": "external" } ], "gene_names_uniprotkb": "CLSTN3", "gene_names_refseq": "CLSTN3", "protein_names_uniprotkb": "Calsyntenin-3", "protein_names_refseq": "alc-beta; alcadein-beta; calsyntenin-3 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:509969)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16305752;18158283", "class_list": "", "function": "Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation. Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with both neurexin-alpha and neurexin-beta proteins at the presynaptic membrane (By similarity). Regulates the balance between excitatory and inhibitory synapses by inhibiting formation of excitatory parallel-fiber synapses and promoting formation of inhibitory synapses in the same neuron (By similarity). May also be involved in ascorbate (vitamin C) uptake via its interaction with SLC23A2/SVCT2. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Results indicate that calsyntenins function outside the nervous system and potentially are modulators of endocrine function., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q0V7L7", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0098632 cell-cell adhesion mediator activity;GO:0042043 neurexin family protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0009986 cell surface;GO:0030425 dendrite;GO:0045211 postsynaptic membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0051965 positive regulation of synapse assembly;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0050806 positive regulation of synaptic transmission;GO:1904862 inhibitory synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0VCN6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIK5-1", "uniprot_id": [ { "id": "DDX1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIK5", "type": "external" } ], "mass": 82414.0, "length": 740, "protein_name": "ATP-dependent RNA helicase DDX1", "gene_name": "DDX1", "organism": "Bovine", "refseq_name": "ATP-dependent RNA helicase DDX1", "refseq_ac": [ { "id": "NP_001068936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068936", "type": "external" } ], "gene_names_uniprotkb": "DDX1", "gene_names_refseq": "DDX1", "protein_names_uniprotkb": "ATP-dependent RNA helicase DDX1; 3.6.4.13; DEAD box protein 1", "protein_names_refseq": "ATP-dependent RNA helicase DDX1; DEAD (Asp-Glu-Ala-Asp) box helicase 1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box protein 1; DEAD/H-box helicase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:510816)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. Possesses 5' single-stranded RNA overhang nuclease activity. Possesses ATPase activity on various RNA, but not DNA polynucleotides. May play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. Together with RELA, acts as a coactivator to enhance NF-kappa-B-mediated transcriptional activation. Acts as a positive transcriptional regulator of cyclin CCND2 expression. Binds to the cyclin CCND2 promoter region. Associates with chromatin at the NF-kappa-B promoter region via association with RELA. Binds to poly(A) RNA. May be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. It is also an accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. Cooperates with ZBTB8OS (also known as archease) for the guanylylation of RTCB, a key intermediate step in activation of the tRNA ligase. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Specifically binds (via helicase ATP-binding domain) on both short and long poly(I:C) dsRNA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; RNA helicase., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0033677 DNA/RNA helicase activity;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIK5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KI45-1", "uniprot_id": [ { "id": "TM10C_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KI45", "type": "external" } ], "mass": 49785.0, "length": 426, "protein_name": "tRNA methyltransferase 10 homolog C", "gene_name": "TRMT10C", "organism": "Bovine", "refseq_name": "tRNA methyltransferase 10 homolog C", "refseq_ac": [ { "id": "NP_001039788", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039788", "type": "external" } ], "gene_names_uniprotkb": "TRMT10C; MRPP1; RG9MTD1", "gene_names_refseq": "RG9MTD1; TRMT10C", "protein_names_uniprotkb": "tRNA methyltransferase 10 homolog C; 2.1.1.-; 2.1.1.218; 2.1.1.221; Mitochondrial RNase P protein 1; Mitochondrial ribonuclease P protein 1; RNA (guanine-9-)-methyltransferase domain-containing protein 1; mRNA methyladenosine-N(1)-methyltransferase; tRNA (adenine(9)-N(1))-methyltransferase; tRNA (guanine(9)-N(1))-methyltransferase", "protein_names_refseq": "RNA (guanine-9-) methyltransferase domain containing 1; RNA (guanine-9-)-methyltransferase domain-containing protein 1; mRNA methyladenosine-N(1)-methyltransferase; mitochondrial RNase P protein 1; mitochondrial ribonuclease P protein 1; tRNA (adenine(9)-N(1))-methyltransferase; tRNA (guanine(9)-N(1))-methyltransferase; tRNA methyltransferase 10 homolog C", "tax_id": 9913, "disease": "", "pathway": " (bta:532418)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit. The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme. In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.220", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.220", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.221", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.221", "type": "external" }, { "id": "2.1.1.218", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.218", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0000049 tRNA binding;GO:0052905 tRNA (guanosine(9)-N1)-methyltransferase activity;GO:0160106 tRNA (adenine(9)-N1)-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0000964 mitochondrial RNA 5'-end processing;GO:0006397 mRNA processing;GO:0070131 positive regulation of mitochondrial translation;GO:0070901 mitochondrial tRNA methylation;GO:0090646 mitochondrial tRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KI45-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ86-1", "uniprot_id": [ { "id": "TBA1D_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ86", "type": "external" } ], "mass": 50283.0, "length": 452, "protein_name": "Tubulin alpha-1D chain", "gene_name": "TUBA1D", "organism": "Bovine", "refseq_name": "tubulin alpha-1D chain", "refseq_ac": [ { "id": "NP_001039875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039875", "type": "external" } ], "gene_names_uniprotkb": "TUBA1D", "gene_names_refseq": "TUBA1D; TUBA3C; TUBA3D", "protein_names_uniprotkb": "Tubulin alpha-1D chain; 3.6.5.-", "protein_names_refseq": "tubulin alpha-1D chain; tubulin, alpha 3c", "tax_id": 9913, "disease": "", "pathway": " (bta:535605)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "2207090;6504138;7704569", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:2207090, PubMed:6504138, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:2207090, PubMed:6504138, PubMed:7704569)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization;GO:0007017 microtubule-based process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2HJ86-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIB6-1", "uniprot_id": [ { "id": "DDIT3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIB6", "type": "external" } ], "mass": 19003.0, "length": 168, "protein_name": "DNA damage-inducible transcript 3 protein", "gene_name": "DDIT3", "organism": "Bovine", "refseq_name": "DNA damage-inducible transcript 3 protein", "refseq_ac": [ { "id": "NP_001071631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071631", "type": "external" } ], "gene_names_uniprotkb": "DDIT3; CHOP10; CHOP; GADD153", "gene_names_refseq": "CHOP-10; CHOP; DDIT3", "protein_names_uniprotkb": "DNA damage-inducible transcript 3 protein; C/EBP zeta; C/EBP-homologous protein 10; C/EBP-homologous protein; CCAAT/enhancer-binding protein homologous protein; CHOP-10; CHOP; DDIT-3; Growth arrest and DNA-damage-inducible protein GADD153", "protein_names_refseq": "C/EBP zeta; C/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; DDIT-3; DNA damage-inducible transcript 3 protein; growth arrest and DNA-damage-inducible protein GADD153", "tax_id": 9913, "disease": "", "pathway": " (bta:777788)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "33361422", "class_list": "", "function": "DDIT3 Targets Innate Immunity via the DDIT3-OTUD1-MAVS Pathway To Promote Bovine Viral Diarrhea Virus Replication. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0036488 CHOP-C/EBP complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1990622 CHOP-ATF3 complex;GO:1990617 CHOP-ATF4 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010506 regulation of autophagy;GO:0042594 response to starvation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0IIB6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCA5-1", "uniprot_id": [ { "id": "SAMH1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCA5", "type": "external" } ], "mass": 68239.0, "length": 589, "protein_name": "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1", "gene_name": "SAMHD1", "organism": "Bovine", "refseq_name": "deoxynucleoside triphosphate triphosphohydrolase SAMHD1", "refseq_ac": [ { "id": "NP_001069329", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069329", "type": "external" } ], "gene_names_uniprotkb": "SAMHD1", "gene_names_refseq": "SAMHD1", "protein_names_uniprotkb": "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; 3.1.5.-; dNTPase", "protein_names_refseq": "SAM domain and HD domain-containing protein 1; dNTPase; deoxynucleoside triphosphate triphosphohydrolase SAMHD1", "tax_id": 9913, "disease": "", "pathway": " (bta:524683); (R-BTA-8956319)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "33751400", "class_list": "", "function": "Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks (By similarity). Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Likewise, suppresses LINE-1 retrotransposon activity (By similarity). In addition to virus restriction, dNTPase activity acts as a regulator of DNA precursor pools by regulating dNTP pools. Functions during S phase at stalled DNA replication forks to promote the resection of gapped or reversed forks: acts by stimulating the exonuclease activity of MRE11, activating the ATR-CHK1 pathway and allowing the forks to restart replication. Its ability to promote degradation of nascent DNA at stalled replication forks is required to prevent induction of type I interferons, thereby preventing chronic inflammation. Ability to promote DNA end resection at stalled replication forks is independent of dNTPase activity (By similarity). Enhances immunoglobulin hypermutation in B-lymphocytes by promoting transversion mutation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Role of Intracellular Distribution of Feline and Bovine SAMHD1 Proteins in Lentiviral Restriction., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.5.-", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:0003697 single-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0005694 chromosome;GO:0005654 nucleoplasm;GO:0097197 tetraspanin-enriched microdomain", "go_biological_process": "GO:0045087 innate immune response;GO:0051289 protein homotetramerization;GO:0051607 defense response to virus;GO:0006203 dGTP catabolic process;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VCA5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98107-1", "uniprot_id": [ { "id": "LYAM2_BOVIN", "url": "https://www.uniprot.org/uniprot/P98107", "type": "external" } ], "mass": 53200.0, "length": 485, "protein_name": "E-selectin", "gene_name": "SELE", "organism": "Bovine", "refseq_name": "E-selectin precursor", "refseq_ac": [ { "id": "NP_776606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776606", "type": "external" } ], "gene_names_uniprotkb": "SELE", "gene_names_refseq": "SELE", "protein_names_uniprotkb": "E-selectin; CD62 antigen-like family member E; ELAM-1; Endothelial leukocyte adhesion molecule 1; LECAM2; Leukocyte-endothelial cell adhesion molecule 2", "protein_names_refseq": "CD62 antigen-like family member E; E-selectin precursor; E-selectin; ELAM-1; LECAM2; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule 1; leukocyte-endothelial cell adhesion molecule 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281484); (R-BTA-202733)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "27033411;28419109;7690465", "class_list": "", "function": "Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Five single nucleotide polymorphisms (SNPs) from different exons in selectin SELP, two in selectin SELL and one in selectin SELE were taken forward to genotyping in 337 Holstein Friesian heifers using PCR-RFLP. Publication Status: Online-Only, [RefSeq, PubMed]; The e-selectin/biliverdin reductase pathway participates in the inhibitory process of hypoxia in pulmonary artery endothelial cell apoptosis which is mediated by the mitochondrial-dependent apoptosis pathway., [RefSeq, PubMed]", "predicted_glycosites": 11, "predicted_n_glycosites": 10, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 11, "binding_glycan_count": 0, "secondary_ac_list": "A6QP78", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0004888 transmembrane signaling receptor activity;GO:0005509 calcium ion binding;GO:0033691 sialic acid binding;GO:0043274 phospholipase binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005905 clathrin-coated pit;GO:0048471 perinuclear region of cytoplasm;GO:0009897 external side of plasma membrane;GO:0005901 caveola", "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0034097 response to cytokine;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0050901 leukocyte tethering or rolling", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P98107-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1ZYR0-1", "uniprot_id": [ { "id": "CLN5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1ZYR0", "type": "external" } ], "mass": 41227.0, "length": 358, "protein_name": "Bis(monoacylglycero)phosphate synthase CLN5", "gene_name": "CLN5", "organism": "Bovine", "refseq_name": "bis(monoacylglycero)phosphate synthase CLN5", "refseq_ac": [ { "id": "NP_001039764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039764", "type": "external" } ], "gene_names_uniprotkb": "CLN5; BMPS", "gene_names_refseq": "CLN5", "protein_names_uniprotkb": "Bis(monoacylglycero)phosphate synthase CLN5; 2.3.1.-; 3.1.2.22; BMP synthase CLN5; Ceroid-lipofuscinosis neuronal protein 5; Palmitoyl protein thioesterase CLN5; Protein CLN5; S-depalmitoylase CLN5", "protein_names_refseq": "BMP synthase CLN5; S-depalmitoylase CLN5; bis(monoacylglycero)phosphate synthase CLN5; ceroid-lipofuscinosis neuronal protein 5; ceroid-lipofuscinosis, neuronal 5; palmitoyl protein thioesterase CLN5", "tax_id": 9913, "disease": "", "pathway": " (bta:529186)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "16935476;16974076", "class_list": "", "function": "Catalyzes the synthesis of bis(monoacylglycero)phosphate (BMP) via transacylation of 2 molecules of lysophosphatidylglycerol (LPG). BMP also known as lysobisphosphatidic acid plays a key role in the formation of intraluminal vesicles and in maintaining intracellular cholesterol homeostasis. Can use only LPG as the exclusive lysophospholipid acyl donor for base exchange and displays BMP synthase activity towards various LPGs (LPG 14:0, LPG 16:0, LPG 18:0, LPG 18:1) with a higher preference for longer chain lengths. Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity in vitro and most likely plays a role in protein S-depalmitoylation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The candidate genes for bovine Neuronal Ceroid Lipofuscinosis, CLN3, CLN5 and CLN6, have been mapped to facilitate linkage analysis in cattle and sheep., [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" } ], "go_molecular_function": "GO:0005537 D-mannose binding;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0008474 palmitoyl-(protein) hydrolase activity;GO:0052816 long-chain fatty acyl-CoA hydrolase activity;GO:0160121 bis(monoacylglycero)phosphate synthase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007420 brain development;GO:0007040 lysosome organization;GO:0042147 retrograde transport, endosome to Golgi;GO:0022008 neurogenesis;GO:0007042 lysosomal lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q1ZYR0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBX0-1", "uniprot_id": [ { "id": "ZPR1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBX0", "type": "external" } ], "mass": 51015.0, "length": 459, "protein_name": "Zinc finger protein ZPR1", "gene_name": "ZNF259; ZPR1", "organism": "Bovine", "refseq_name": "zinc finger protein ZPR1", "refseq_ac": [ { "id": "NP_001033593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033593", "type": "external" } ], "gene_names_uniprotkb": "ZNF259; ZPR1; ZPR1", "gene_names_refseq": "ZNF259; ZPR1", "protein_names_uniprotkb": "Zinc finger protein ZPR1; Zinc finger protein 259", "protein_names_refseq": "zinc finger protein 259; zinc finger protein ZPR1", "tax_id": 9913, "disease": "", "pathway": " (bta:504523)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044183 protein folding chaperone;GO:0031369 translation initiation factor binding;GO:0030971 receptor tyrosine kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030424 axon", "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0033120 positive regulation of RNA splicing;GO:0006397 mRNA processing;GO:0010628 positive regulation of gene expression;GO:0021510 spinal cord development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBX0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA06-1", "uniprot_id": [ { "id": "AURKA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TA06", "type": "external" } ], "mass": 45462.0, "length": 402, "protein_name": "Aurora kinase A", "gene_name": "AURKA", "organism": "Bovine", "refseq_name": "aurora kinase A", "refseq_ac": [ { "id": "NP_001033117", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033117", "type": "external" } ], "gene_names_uniprotkb": "AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6", "gene_names_refseq": "ARK-1; AURKA", "protein_names_uniprotkb": "Aurora kinase A; 2.7.11.1; ARK-1; Aurora 2; Aurora-related kinase 1; Aurora/IPL1-related kinase 1; Ipl1- and aurora-related kinase 1; Serine/threonine-protein kinase 15; Serine/threonine-protein kinase 6; Serine/threonine-protein kinase Ayk1; Serine/threonine-protein kinase aurora-A", "protein_names_refseq": "Aurora-A; aurora 2; aurora kinase A; aurora-related kinase 1; aurora/IPL1-related kinase 1; ipl1- and aurora-related kinase 1; serine/threonine-protein kinase 15; serine/threonine-protein kinase 6; serine/threonine-protein kinase Ayk1; serine/threonine-protein kinase aurora-A", "tax_id": 9913, "disease": "", "pathway": " (bta:504437); (R-BTA-174178); (R-BTA-2565942); (R-BTA-6804114); (R-BTA-6804756); (R-BTA-8854050); (R-BTA-8854518); (R-BTA-8854521)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "17687118", "class_list": "", "function": "Aurora A was the most abundant form in oocytes, both at mRNA and protein levels, in bovine oocytes during meiotic maturation., [RefSeq, PubMed]; Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression (By similarity). Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle, centrosome duplication, centrosome separation as well as maturation, chromosomal alignment, spindle assembly checkpoint, and cytokinesis (By similarity). Required for normal spindle positioning during mitosis and for the localization of NUMA1 and DCTN1 to the cell cortex during metaphase (By similarity). Required for initial activation of CDK1 at centrosomes (By similarity). Phosphorylates numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B, DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1, TACC3, p53/TP53 and TPX2. Phosphorylates MCRS1 which is required for MCRS1-mediated kinetochore fiber assembly and mitotic progression (By similarity). Regulates KIF2A tubulin depolymerase activity (By similarity). Required for normal axon formation (By similarity). Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization (By similarity). Also acts as a key regulatory component of the p53/TP53 pathway, and particularly the checkpoint-response pathways critical for oncogenic transformation of cells, by phosphorylating and destabilizing p53/TP53 (By similarity). Phosphorylates its own inhibitors, the protein phosphatase type 1 (PP1) isoforms, to inhibit their activity (By similarity). Inhibits cilia outgrowth (By similarity). Required for cilia disassembly via phosphorylation of HDAC6 and subsequent deacetylation of alpha-tubulin (By similarity). Regulates protein levels of the anti-apoptosis protein BIRC5 by suppressing the expression of the SCF(FBXL7) E3 ubiquitin-protein ligase substrate adapter FBXL7 through the phosphorylation of the transcription factor FOXP1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0045931 positive regulation of mitotic cell cycle;GO:0051301 cell division;GO:0007052 mitotic spindle organization;GO:0007100 mitotic centrosome separation;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2TA06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1KZG4-1", "uniprot_id": [ { "id": "FHIT_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1KZG4", "type": "external" } ], "mass": 16951.0, "length": 149, "protein_name": "Bis(5'-adenosyl)-triphosphatase", "gene_name": "FHIT", "organism": "Bovine", "refseq_name": "bis(5'-adenosyl)-triphosphatase", "refseq_ac": [ { "id": "NP_001035736", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035736", "type": "external" } ], "gene_names_uniprotkb": "FHIT", "gene_names_refseq": "FHIT", "protein_names_uniprotkb": "Bis(5'-adenosyl)-triphosphatase; 2.7.7.51; 3.6.1.29; 3.6.2.1; 3.9.1.-; AP3A hydrolase; AP3Aase; Adenosine 5'-monophosphoramidase FHIT; Adenylylsulfatase; Adenylylsulfate-ammonia adenylyltransferase; Diadenosine 5',5'''-P1,P3-triphosphate hydrolase; Dinucleosidetriphosphatase; Fragile histidine triad protein", "protein_names_refseq": "AP3A hydrolase; AP3Aase; adenosine 5'-monophosphoramidase FHIT; adenylylsulfatase; adenylylsulfate-ammonia adenylyltransferase; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase; dinucleosidetriphosphatase; fragile histidine triad protein", "tax_id": 9913, "disease": "", "pathway": " (bta:692183)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "16611727;16719907;18467844;32401148", "class_list": "", "function": "Effects of eight InDel variants in FHIT on milk traits in Xinjiang brown cattle., [RefSeq, PubMed]; Possesses dinucleoside triphosphate hydrolase activity (By similarity). Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (By similarity). Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP (By similarity). Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (By similarity). Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate (By similarity). Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate (By similarity). Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (By similarity). Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways (By similarity). Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis (By similarity). Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity) Functions as a tumor suppressor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The same mRNA isoforms of FHIT were detected in bladder tumors and in healthy tissues, including a novel isoform that was found in this study, suggesting that epigenetic modifications and altered expression profiles are not a hallmark of vesical tumors, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QLK1;Q1KZS9", "ec_number_list": [ { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.4.22.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.-", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "2.7.7.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.51", "type": "external" }, { "id": "3.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0031625 ubiquitin protein ligase binding;GO:0047710 bis(5'-adenosyl)-triphosphatase activity;GO:0047352 adenylylsulfate-ammonia adenylyltransferase activity;GO:0047627 adenylylsulfatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0015964 diadenosine triphosphate catabolic process;GO:0006351 DNA-templated transcription;GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator;GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0006163 purine nucleotide metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q1KZG4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIJ5-1", "uniprot_id": [ { "id": "KDSR_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIJ5", "type": "external" } ], "mass": 36091.0, "length": 332, "protein_name": "3-ketodihydrosphingosine reductase", "gene_name": "KDSR", "organism": "Bovine", "refseq_name": "3-ketodihydrosphingosine reductase precursor", "refseq_ac": [ { "id": "NP_001039384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039384", "type": "external" } ], "gene_names_uniprotkb": "KDSR; FVT1", "gene_names_refseq": "FVT1; KDSR", "protein_names_uniprotkb": "3-ketodihydrosphingosine reductase; 1.1.1.102; 3-dehydrosphinganine reductase; FVT-1; Follicular variant translocation protein 1 homolog; KDS reductase", "protein_names_refseq": "3-dehydrosphinganine reductase; 3-ketodihydrosphingosine reductase precursor; FVT-1; KDS reductase; follicular lymphoma variant translocation 1; follicular variant translocation protein 1 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:505558)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17420465", "class_list": "", "function": "Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; G-to-A missense mutation in FVT1, encoding 3-ketodihydrosphingosine reductase, is a strong candidate for causality of spinal muscular atrophy in cattle., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1MLE5", "ec_number_list": [ { "id": "1.1.1.102", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.102", "type": "external" } ], "go_molecular_function": "GO:0047560 3-dehydrosphinganine reductase activity;GO:0070402 NADPH binding;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane", "go_biological_process": "GO:0006666 3-keto-sphinganine metabolic process;GO:0006686 sphingomyelin biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0046513 ceramide biosynthetic process;GO:0030148 sphingolipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KIJ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JQA7-1", "uniprot_id": [ { "id": "TIGAR_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JQA7", "type": "external" } ], "mass": 29467.0, "length": 270, "protein_name": "Fructose-2,6-bisphosphatase TIGAR", "gene_name": "TIGAR", "organism": "Bovine", "refseq_name": "fructose-2,6-bisphosphatase TIGAR", "refseq_ac": [ { "id": "NP_001069838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069838", "type": "external" } ], "gene_names_uniprotkb": "TIGAR", "gene_names_refseq": "C5H12orf5; TIGAR", "protein_names_uniprotkb": "Fructose-2,6-bisphosphatase TIGAR; 3.1.3.46; TP53-induced glycolysis and apoptosis regulator; TP53-induced glycolysis regulatory phosphatase", "protein_names_refseq": "TP53-induced glycolysis and apoptosis regulator; fructose-2,6-bisphosphatase TIGAR; probable fructose-2,6-bisphosphatase TIGAR", "tax_id": 9913, "disease": "", "pathway": " (bta:615392); (R-BTA-5628897)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (By similarity). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity. In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage. Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation. Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions. Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner. Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses. Involved in intestinal tumor progression., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.105", "type": "external" }, { "id": "3.1.3.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.46", "type": "external" } ], "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol", "go_biological_process": "GO:0043456 regulation of pentose-phosphate shunt;GO:0002931 response to ischemia;GO:0006915 apoptotic process;GO:0071456 cellular response to hypoxia;GO:0006974 DNA damage response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1JQA7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5A0-1", "uniprot_id": [ { "id": "KCNK1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5A0", "type": "external" } ], "mass": 38041.0, "length": 336, "protein_name": "Potassium channel subfamily K member 1", "gene_name": "KCNK1", "organism": "Bovine", "refseq_name": "potassium channel subfamily K member 1", "refseq_ac": [ { "id": "NP_001068675", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068675", "type": "external" } ], "gene_names_uniprotkb": "KCNK1", "gene_names_refseq": "KCNK1", "protein_names_uniprotkb": "Potassium channel subfamily K member 1", "protein_names_refseq": "potassium channel subfamily K member 1; potassium channel, subfamily K, member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:505563); (R-BTA-1299308); (R-BTA-5576886)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues. Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium. The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (By similarity). Channel activity is modulated by activation of serotonin receptors (By similarity). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity. Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (By similarity). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G protein-coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation. The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (By similarity). Permeable to monovalent cations with ion selectivity for K(+) > Rb(+) >> NH4(+) >> Cs(+) = Na(+) = Li(+)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0022841 potassium ion leak channel activity;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity;GO:0005267 potassium channel activity;GO:0005272 sodium channel activity", "go_cellular_component": "GO:0034705 potassium channel complex;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0035725 sodium ion transmembrane transport;GO:0014047 glutamate secretion;GO:0060075 regulation of resting membrane potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5A0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMH8-1", "uniprot_id": [ { "id": "SNX3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMH8", "type": "external" } ], "mass": 18762.0, "length": 162, "protein_name": "Sorting nexin-3", "gene_name": "SNX3", "organism": "Bovine", "refseq_name": "sorting nexin-3", "refseq_ac": [ { "id": "NP_001073246", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073246", "type": "external" } ], "gene_names_uniprotkb": "SNX3", "gene_names_refseq": "SNX3", "protein_names_uniprotkb": "Sorting nexin-3", "protein_names_refseq": "sorting nexin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:528265); (R-BTA-3238698)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Can also bind phosphatidylinositol 4-phosphate (PtdIns(P4)), phosphatidylinositol 5-phosphate (PtdIns(P5)) and phosphatidylinositol 3,5-biphosphate (PtdIns(3,5)P2). Plays a role in protein transport between cellular compartments. Together with RAB7A facilitates endosome membrane association of the retromer cargo-selective subcomplex (CSC). May act in part as component of the SNX3-retromer complex which mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G. Not involved in EGFR degradation. Involved in the regulation of phagocytosis in dendritic cells possibly by regulating EEA1 recruitment to the nascent phagosomes. Involved in iron homeostasis through regulation of endocytic recycling of the transferrin receptor Tfrc presuambly by delivering the transferrin:transferrin receptor complex to recycling endosomes; the function may involve the CSC retromer subcomplex. Involved in regulation of neurite outgrowth in primary neurons. Required for trafficking of WLS to the early endosome for recycling which promotes both canonical and non-canonical WNT signaling and is essential for neural tube closure., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:1905394 retromer complex binding", "go_cellular_component": "GO:0005769 early endosome;GO:0031901 early endosome membrane;GO:0010008 endosome membrane;GO:0030136 clathrin-coated vesicle;GO:0030904 retromer complex", "go_biological_process": "GO:0051223 regulation of protein transport;GO:0010976 positive regulation of neuron projection development;GO:0015031 protein transport;GO:0030111 regulation of Wnt signaling pathway;GO:0050765 negative regulation of phagocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMH8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCY0-1", "uniprot_id": [ { "id": "AT2A1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCY0", "type": "external" } ], "mass": 109290.0, "length": 993, "protein_name": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 1", "gene_name": "ATP2A1", "organism": "Bovine", "refseq_name": "sarcoplasmic/endoplasmic reticulum calcium ATPase 1", "refseq_ac": [ { "id": "NP_001069235", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069235", "type": "external" } ], "gene_names_uniprotkb": "ATP2A1", "gene_names_refseq": "ATP2A1; SERCA1", "protein_names_uniprotkb": "Sarcoplasmic/endoplasmic reticulum calcium ATPase 1; 7.2.2.10; Calcium pump 1; Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca(2+) ATPase; SERCA1; SR Ca(2+)-ATPase 1", "protein_names_refseq": "ATPase, Ca++ transporting, fast twitch 1; SR Ca(2+)-ATPase 1; calcium pump 1; endoplasmic reticulum class 1/2 Ca(2+) ATPase; sarcoplasmic/endoplasmic reticulum calcium ATPase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:518117); (R-BTA-418359); (R-BTA-5578775); (R-BTA-936837)", "pathway_count": 4, "publication_count": 6, "publication_id_list": "18344998;18786632;19116366;22387132;25288803;26482047", "class_list": "", "function": "Catalyzes the hydrolysis of ATP coupled with the transport of calcium., [UniProtKB, UniProtKB]; Crystal structure of SERCA, crystallized in the E1 conformation and determined at 2.9A resolution, [RefSeq, PubMed]; In this study, we provide biochemical evidence for a selective deficiency in SERCA1 protein levels in sarcoplasmic reticulum membranes from Chianina cattle with congenital pseudomyotonia, [RefSeq, PubMed]; Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen (PubMed:22387132). Contributes to calcium sequestration involved in muscular excitation/contraction., [UniProtKB, PubMed, UniProtKB]; Mutation in ATP2A1 is associated with congenital muscular dystony type 1, [RefSeq, PubMed]; Rescue of mutated SERCA1 to sarcoplasmic reticulum membrane can re-establish resting cytosolic Ca(2+) concentration and prevent the appearance of pathological signs of cattle pseudomyotonia, [RefSeq, PubMed]; Results demonstrate that a cattle congenital pseudomyotonia is caused by a SERCA1 deficiency, resulting from a defect in the ATP2A1 gene, [RefSeq, PubMed]; Study reports the identification of a missense mutation in ATP2A1 in congential pseudomytonia of Chianina cattle; mutation analysis of ATP2A1 exons revealed a perfectly associated missense mutation in exon 6 (c.491G>A) leading to p.Arg164His substitution, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.2.2.10", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.10", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0005388 P-type calcium transporter activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0016020 membrane;GO:0033017 sarcoplasmic reticulum membrane;GO:0005739 mitochondrion", "go_biological_process": "GO:1902082 positive regulation of calcium ion import into sarcoplasmic reticulum;GO:0006874 intracellular calcium ion homeostasis;GO:0070588 calcium ion transmembrane transport;GO:1990036 calcium ion import into sarcoplasmic reticulum;GO:1901896 positive regulation of ATPase-coupled calcium transmembrane transporter activity", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q0VCY0-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8R6-1", "uniprot_id": [ { "id": "HEXA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8R6", "type": "external" } ], "mass": 60353.0, "length": 529, "protein_name": "Beta-hexosaminidase subunit alpha", "gene_name": "HEXA", "organism": "Bovine", "refseq_name": "beta-hexosaminidase subunit alpha precursor", "refseq_ac": [ { "id": "NP_001068632", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068632", "type": "external" } ], "gene_names_uniprotkb": "HEXA", "gene_names_refseq": "HEXA", "protein_names_uniprotkb": "Beta-hexosaminidase subunit alpha; 3.2.1.52; Beta-N-acetylhexosaminidase subunit alpha; Hexosaminidase subunit A; N-acetyl-beta-glucosaminidase subunit alpha", "protein_names_refseq": "N-acetyl-beta-glucosaminidase subunit alpha; beta-N-acetylhexosaminidase subunit alpha; beta-hexosaminidase subunit alpha precursor; beta-hexosaminidase subunit alpha; hexosaminidase A (alpha polypeptide); hexosaminidase subunit A", "tax_id": 9913, "disease": "", "pathway": " (bta:504468); (R-BTA-2022857); (R-BTA-2024101); (R-BTA-2160916); (R-BTA-9840310)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "16305752;18513278", "class_list": "glycogene;glycosylhydrolase", "function": "Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme S is as active as the isozyme A on the anionic bis-sulfated glycans, the chondroitin-6-sulfate trisaccharide (C6S-3), and the dermatan sulfate pentasaccharide, and the sulfated glycosphingolipid SM2. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SNPs in the HEXA region on chromosome 10 have a protective effect against Bovine spongiform encephalopathy., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" } ], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0008375 acetylglucosaminyltransferase activity;GO:0004563 beta-N-acetylhexosaminidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005764 lysosome;GO:0042582 azurophil granule", "go_biological_process": "GO:0006689 ganglioside catabolic process;GO:0030209 dermatan sulfate proteoglycan catabolic process;GO:0005975 carbohydrate metabolic process;GO:0006024 glycosaminoglycan biosynthetic process;GO:0030203 glycosaminoglycan metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0V8R6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBW6-1", "uniprot_id": [ { "id": "ARL3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBW6", "type": "external" } ], "mass": 20505.0, "length": 182, "protein_name": "ADP-ribosylation factor-like protein 3", "gene_name": "ARL3", "organism": "Bovine", "refseq_name": "ADP-ribosylation factor-like protein 3", "refseq_ac": [ { "id": "NP_001033656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033656", "type": "external" } ], "gene_names_uniprotkb": "ARL3", "gene_names_refseq": "ARL3", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 3", "protein_names_refseq": "ADP-ribosylation factor-like 3; ADP-ribosylation factor-like protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:540040); (R-BTA-5624138)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008017 microtubule binding;GO:0046872 metal ion binding;GO:0019003 GDP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0015031 protein transport;GO:0001822 kidney development;GO:0007264 small GTPase-mediated signal transduction;GO:0060271 cilium assembly;GO:0000281 mitotic cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBW6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28044-1", "uniprot_id": [ { "id": "ADRB2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28044", "type": "external" } ], "mass": 47136.0, "length": 418, "protein_name": "Beta-2 adrenergic receptor", "gene_name": "ADRB2", "organism": "Bovine", "refseq_name": "beta-2 adrenergic receptor", "refseq_ac": [ { "id": "NP_776656", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776656", "type": "external" } ], "gene_names_uniprotkb": "ADRB2", "gene_names_refseq": "ADRB2", "protein_names_uniprotkb": "Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor", "protein_names_refseq": "adrenergic receptor beta 2; adrenergic, beta-2, receptor, surface; adrenergic, beta-2-, receptor, surface; adrenoceptor beta 2, surface; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281605); (R-BTA-390696); (R-BTA-418555); (R-BTA-5689880); (R-BTA-8856825); (R-BTA-8856828)", "pathway_count": 6, "publication_count": 6, "publication_id_list": "10342858;12586313;15760672;20149890;25296113;25497806", "class_list": "", "function": "ADRb2 shows lipid scrambling activity. Publication Status: Online-Only, [RefSeq, PubMed]; Beta 1,2 and 3-adrenergic receptors in cattle were positively associated with hepatic activities of gluconeogenetic enzymes and with plasma glucose levels, suggesting functional importance, [RefSeq, PubMed]; G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, activating bifurcated signaling pathways. ADRB2 binds epinephrine (Epi) with an approximately 30-fold greater affinity than norepinephrine (NE). In the heart, Epi- and NE-activated ADRB2 induces rapid and slow cardiomyocyte contraction rate, respectively. Both NE and Epi promote coupling to G(s)/PKA pathway to regulate myocyte contraction rate. Epi also promotes ADRB2 coupling to G(i) proteins to exert cardioprotective effects especially in the conditions of hypoxia and oxidative stress through the G(i)/PI3K/Akt signaling pathway. ADRB2-G(s) signaling delivers proapoptotic signals in cardiomyocytes although G(i)-mediated survival effect appears to predominate. ADRB2 also transduces signals independently of PKA to regulate cellular pH by modulating Na(+)/H(+) exchanger SLC9A3 function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Of the beta-adrenergic receptors, adrenergic beta(2)-receptor type was most highly expressed in the mammary gland of dairy cows followed by beta(1) and beta(3), [RefSeq, PubMed]; Relationship between luteal concentrations of oxytocin (OT), noradrenaline (NA), progesterone (P4), oxytocin receptors (OT-R) and beta(2)-adrenoreceptors (beta(2)-R) gene expression and their protein level throughout the estrous cycle, [RefSeq, PubMed]; These results indicate dependence of hepatic glucocorticoid and adrenergic receptors on stage of maturation in neonatal calves and emphasize the association of alpha1-adrenergic receptor and glucocorticoid receptor with neonatal glucose and lipid metabolism., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q29RK5", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0001540 amyloid-beta binding;GO:0015459 potassium channel regulator activity;GO:0008179 adenylate cyclase binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0098992 neuronal dense core vesicle;GO:0005634 nucleus;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006940 regulation of smooth muscle contraction;GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:1904646 cellular response to amyloid-beta;GO:0045744 negative regulation of G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q28044-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B81-1", "uniprot_id": [ { "id": "PCFT_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B81", "type": "external" } ], "mass": 50428.0, "length": 459, "protein_name": "Proton-coupled folate transporter", "gene_name": "SLC46A1", "organism": "Bovine", "refseq_name": "proton-coupled folate transporter", "refseq_ac": [ { "id": "NP_001073053", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073053", "type": "external" } ], "gene_names_uniprotkb": "SLC46A1; HCP1; PCFT", "gene_names_refseq": "SLC46A1; TRPE", "protein_names_uniprotkb": "Proton-coupled folate transporter; Heme carrier protein 1; Solute carrier family 46 member 1", "protein_names_refseq": "PCFT/HCP1; heme carrier protein 1; proton-coupled folate transporter; retinal pigment epithelilum transporter; retinal pigment epithelium transporter", "tax_id": 9913, "disease": "", "pathway": " (bta:511097); (R-BTA-196757); (R-BTA-917937); (R-BTA-9707616)", "pathway_count": 4, "publication_count": 2, "publication_id_list": "16305752;17335806", "class_list": "", "function": "Proton-coupled folate symporter that mediates folate absorption using an H(+) gradient as a driving force (By similarity). Involved in the intestinal absorption of folates at the brush-border membrane of the proximal jejunum, and the transport from blood to cerebrospinal fluid across the choroid plexus (By similarity). Functions at acidic pH via alternate outward- and inward-open conformation states (By similarity). Protonation of residues in the outward open state primes the protein for transport (By similarity). Binding of folate promotes breaking of salt bridge network and subsequent closure of the extracellular gate, leading to the inward-open state and release of protons and folate (By similarity). Also able to transport antifolate drugs, such as methotrexate and pemetrexed (By similarity). Involved in FOLR1-mediated endocytosis by serving as a route of export of folates from acidified endosomes (By similarity). Also acts as a lower-affinity, pH-independent heme carrier protein and constitutes the main importer of heme in the intestine (By similarity). Imports heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, in hepatocytes and in the renal epithelial cells (PubMed:17335806). Hence, participates in the trafficking of heme and increases intracellular iron content (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A1L0R5;A1L547", "ec_number_list": [], "go_molecular_function": "GO:0015350 methotrexate transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0015232 heme transmembrane transporter activity;GO:0015293 symporter activity;GO:0005542 folic acid binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0046654 tetrahydrofolate biosynthetic process;GO:0055085 transmembrane transport;GO:0015886 heme transport;GO:0015884 folic acid transport;GO:1904447 folate import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q05B81-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2NKY7-1", "uniprot_id": [ { "id": "SEPT2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2NKY7", "type": "external" } ], "mass": 41572.0, "length": 361, "protein_name": "Septin-2", "gene_name": "SEPTIN2", "organism": "Bovine", "refseq_name": "septin-2", "refseq_ac": [ { "id": "NP_001039557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039557", "type": "external" } ], "gene_names_uniprotkb": "SEPTIN2; SEPT2", "gene_names_refseq": "SEPT2; SEPTIN2", "protein_names_uniprotkb": "Septin-2", "protein_names_refseq": "septin-2", "tax_id": 9913, "disease": "", "pathway": " (bta:511612); (R-BTA-5620912)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB]; Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030234 enzyme regulator activity", "go_cellular_component": "GO:0005940 septin ring;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0031514 motile cilium;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0060271 cilium assembly;GO:0008104 intracellular protein localization;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2NKY7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ46-1", "uniprot_id": [ { "id": "RNF8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ46", "type": "external" } ], "mass": 55729.0, "length": 487, "protein_name": "E3 ubiquitin-protein ligase RNF8", "gene_name": "RNF8", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase RNF8", "refseq_ac": [ { "id": "NP_001039681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039681", "type": "external" } ], "gene_names_uniprotkb": "RNF8", "gene_names_refseq": "RNF8", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF8; 2.3.2.27; RING finger protein 8; RING-type E3 ubiquitin transferase RNF8", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF8; RING-type E3 ubiquitin transferase RNF8", "tax_id": 9913, "disease": "", "pathway": " (bta:515933); (R-BTA-5693565); (R-BTA-5693571); (R-BTA-5693607); (R-BTA-69473)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Promotes the recruitment of NBN to DNA damage sites by catalyzing 'Lys-6'-linked ubiquitination of NBN. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites (By similarity). Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity (By similarity). In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2 (By similarity)., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0061630 ubiquitin protein ligase activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030496 midbody;GO:0035861 site of double-strand break", "go_biological_process": "GO:0051301 cell division;GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0010212 response to ionizing radiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ46-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q32LM8-1", "uniprot_id": [ { "id": "NRM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q32LM8", "type": "external" } ], "mass": 29638.0, "length": 262, "protein_name": "Nurim", "gene_name": "NRM", "organism": "Bovine", "refseq_name": "nurim", "refseq_ac": [ { "id": "NP_001032685", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032685", "type": "external" } ], "gene_names_uniprotkb": "NRM", "gene_names_refseq": "NRM", "protein_names_uniprotkb": "Nurim; Nuclear envelope membrane protein; Nuclear rim protein", "protein_names_refseq": "nuclear envelope membrane protein; nuclear rim protein; nurim", "tax_id": 9913, "disease": "", "pathway": " (bta:511167)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q32LM8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q3T0Q4-1", "uniprot_id": [ { "id": "NDKB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q3T0Q4", "type": "external" } ], "mass": 17316.0, "length": 152, "protein_name": "Nucleoside diphosphate kinase B", "gene_name": "NME2", "organism": "Bovine", "refseq_name": "nucleoside diphosphate kinase B", "refseq_ac": [ { "id": "NP_001069844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069844", "type": "external" } ], "gene_names_uniprotkb": "NME2", "gene_names_refseq": "NDPK B; NDPK2; NME2", "protein_names_uniprotkb": "Nucleoside diphosphate kinase B; 2.7.13.3; 2.7.4.6; Histidine protein kinase NDKB; NDP kinase B; NDPK B; NDPK2; Nucleoside diphosphate kinases 2", "protein_names_refseq": "NDK B; NDP kinase B; histidine protein kinase NDKB; non-metastatic cells 2, protein (NM23B) expressed in; nucleoside diphosphate kinase B; nucleoside diphosphate kinases 2", "tax_id": 9913, "disease": "", "pathway": " (bta:615447); (R-BTA-499943); (R-BTA-6798695); (R-BTA-9748787); (R-BTA-9755088)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "12486123", "class_list": "", "function": "Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:12486123). Also functions as a histidine protein kinase by transferring the phosphoryl group from the phosphohistidine intermediate to a histidine residue in target proteins (PubMed:12486123). Phosphorylates the GNB1 subunit of heterotrimeric G proteins at 'His-266', generating a high-energy phosphate group that promotes GTP formation and enables receptor-independent activation of heterotrimeric G proteins (PubMed:12486123). Also phosphorylates KCNN4 at 'His-358', leading to activation of its intermediate conductance calcium-activated potassium channel activity, Ca(2+) influx, and subsequent activation of B and T cells. Additionally involved in transcriptional regulation through direct DNA binding and chromatin remodeling. In this context, functions as a single-stranded DNA binding protein that binds and stabilizes the G-quadruplex (G4) structures within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter, facilitating recruitment of additional single-strand DNA binding proteins and activation of MYC transcription. G4 DNA-binding activity is independent of its nucleoside diphosphate kinase function and recognizes both folded and unfolded G4 structures (By similarity). With NME1, may regulate acetyl-CoA (AcCoA) usage between histone acetylation and fatty acid synthesis by targeting AcCoA release at ATP-rich, HAT-associated chromatin regions (By similarity). Also negatively regulates Rho activity by interacting with AKAP13/LBC (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0120225 coenzyme A binding;GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0071944 cell periphery", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007229 integrin-mediated signaling pathway;GO:0043066 negative regulation of apoptotic process;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0042304 regulation of fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q3T0Q4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DK7-1", "uniprot_id": [ { "id": "S2529_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DK7", "type": "external" } ], "mass": 31866.0, "length": 298, "protein_name": "Mitochondrial basic amino acids transporter", "gene_name": "SLC25A29", "organism": "Bovine", "refseq_name": "mitochondrial basic amino acids transporter", "refseq_ac": [ { "id": "NP_001071339", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071339", "type": "external" } ], "gene_names_uniprotkb": "SLC25A29; ORNT3", "gene_names_refseq": "SLC25A29", "protein_names_uniprotkb": "Mitochondrial basic amino acids transporter; CACT-like; Carnitine/acylcarnitine translocase-like; Mitochondrial carnitine/acylcarnitine carrier protein CACL; Mitochondrial ornithine transporter 3; Solute carrier family 25 member 29", "protein_names_refseq": "carnitine/acylcarnitine translocase-like; mitchondrial carnitine/acylcarnitine carrier protein CACL; mitochondrial basic amino acids transporter; mitochondrial carnitine/acylcarnitine carrier protein CACL; mitochondrial ornithine transporter 3", "tax_id": 9913, "disease": "", "pathway": " (bta:507686); (R-BTA-352230)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial transporter of arginine, lysine, homoarginine, methylarginine and, to a much lesser extent, ornithine and histidine. Does not transport carnitine nor acylcarnitines. Functions by both counter-exchange and uniport mechanisms. Plays a physiological role in the import of basic amino acids into mitochondria for mitochondrial protein synthesis and amino acid degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005289 high-affinity L-arginine transmembrane transporter activity;GO:0005292 high-affinity lysine transmembrane transporter activity;GO:0015174 basic amino acid transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0015822 ornithine transport;GO:0089709 L-histidine transmembrane transport;GO:1903401 L-lysine transmembrane transport;GO:1990575 mitochondrial L-ornithine transmembrane transport;GO:1903826 L-arginine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DK7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ49-1", "uniprot_id": [ { "id": "MOES_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ49", "type": "external" } ], "mass": 67975.0, "length": 577, "protein_name": "Moesin", "gene_name": "MSN", "organism": "Bovine", "refseq_name": "moesin", "refseq_ac": [ { "id": "NP_001039942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039942", "type": "external" } ], "gene_names_uniprotkb": "MSN", "gene_names_refseq": "MSN", "protein_names_uniprotkb": "Moesin; Membrane-organizing extension spike protein", "protein_names_refseq": "membrane-organizing extension spike protein; moesin", "tax_id": 9913, "disease": "", "pathway": " (bta:540426)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "29167409", "class_list": "", "function": "Ezrin-radixin-moesin (ERM) family protein that connects the actin cytoskeleton to the plasma membrane and thereby regulates the structure and function of specific domains of the cell cortex. Tethers actin filaments by oscillating between a resting and an activated state providing transient interactions between moesin and the actin cytoskeleton. Once phosphorylated on its C-terminal threonine, moesin is activated leading to interaction with F-actin and cytoskeletal rearrangement. These rearrangements regulate many cellular processes, including cell shape determination, membrane transport, and signal transduction. The role of moesin is particularly important in immunity acting on both T and B-cells homeostasis and self-tolerance, regulating lymphocyte egress from lymphoid organs (By similarity). Modulates phagolysosomal biogenesis in macrophages (By similarity). Participates also in immunologic synapse formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Study defines a novel role for the sphingosine kinase-S1P-ERM pathways in phosphate-induced vascular smooth muscle cells matrix mineralization and shows that blocking these pathways with pharmacological inhibitors reduces mineralization; these results may inform new therapeutic approaches to inhibit or delay vascular calcification, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding;GO:0050839 cell adhesion molecule binding;GO:0003725 double-stranded RNA binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0009986 cell surface", "go_biological_process": "GO:1902966 positive regulation of protein localization to early endosome;GO:0022614 membrane to membrane docking;GO:0061028 establishment of endothelial barrier;GO:1902115 regulation of organelle assembly;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2HJ49-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCQ1-1", "uniprot_id": [ { "id": "CTBP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCQ1", "type": "external" } ], "mass": 48947.0, "length": 445, "protein_name": "C-terminal-binding protein 2", "gene_name": "CTBP2", "organism": "Bovine", "refseq_name": "C-terminal-binding protein 2", "refseq_ac": [ { "id": "NP_783643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783643", "type": "external" } ], "gene_names_uniprotkb": "CTBP2", "gene_names_refseq": "CTBP2", "protein_names_uniprotkb": "C-terminal-binding protein 2; CtBP2", "protein_names_refseq": "C-terminal-binding protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281730); (R-BTA-4641265); (R-BTA-9764725)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "11163272", "class_list": "", "function": "Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity). Isoform 2 probably acts as a scaffold for specialized synapses., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9GKK1", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0051287 NAD binding;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;GO:0001221 transcription coregulator binding", "go_cellular_component": "GO:0098831 presynaptic active zone cytoplasmic component;GO:0005634 nucleus;GO:0017053 transcription repressor complex;GO:0098684 photoreceptor ribbon synapse;GO:0045202 synapse", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0050872 white fat cell differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VCQ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA37-1", "uniprot_id": [ { "id": "ARL2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TA37", "type": "external" } ], "mass": 20907.0, "length": 184, "protein_name": "ADP-ribosylation factor-like protein 2", "gene_name": "ARL2", "organism": "Bovine", "refseq_name": "ADP-ribosylation factor-like protein 2", "refseq_ac": [ { "id": "NP_001033168", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033168", "type": "external" } ], "gene_names_uniprotkb": "ARL2", "gene_names_refseq": "ARL2", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 2", "protein_names_refseq": "ADP-ribosylation factor-like 2; ADP-ribosylation factor-like protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:511349); (R-BTA-83936); (R-BTA-9648002)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "11809823;12912990;17704193", "class_list": "", "function": "Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019003 GDP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006110 regulation of glycolytic process;GO:0010811 positive regulation of cell-substrate adhesion;GO:0006457 protein folding;GO:1903715 regulation of aerobic respiration;GO:0034260 negative regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2TA37-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27977-1", "uniprot_id": [ { "id": "ITA5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27977", "type": "external" } ], "mass": 125956.0, "length": 1164, "protein_name": "Integrin alpha-5", "gene_name": "ITGA5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ITGA5", "gene_names_refseq": "", "protein_names_uniprotkb": "Integrin alpha-5; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1566948); (R-BTA-1566977); (R-BTA-202733); (R-BTA-216083); (R-BTA-9634597); (R-BTA-9860927)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "7545439", "class_list": "", "function": "Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1. ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (By similarity). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling. ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 14, "predicted_n_glycosites": 14, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 14, "binding_glycan_count": 0, "secondary_ac_list": "F1MK44", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion", "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0023035 CD40 signaling pathway;GO:0001525 angiogenesis;GO:0007229 integrin-mediated signaling pathway;GO:0033627 cell adhesion mediated by integrin", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q27977-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JQE0-1", "uniprot_id": [ { "id": "SNW1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JQE0", "type": "external" } ], "mass": 61505.0, "length": 536, "protein_name": "SNW domain-containing protein 1", "gene_name": "SNW1", "organism": "Bovine", "refseq_name": "SNW domain-containing protein 1", "refseq_ac": [ { "id": "NP_001071302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071302", "type": "external" } ], "gene_names_uniprotkb": "SNW1; SKIIP", "gene_names_refseq": "NCOA-62; SKIIP; SNW1", "protein_names_uniprotkb": "SNW domain-containing protein 1; Nuclear protein SkiP; Ski-interacting protein", "protein_names_refseq": "SKI-interacting protein; SNW domain-containing protein 1; nuclear protein SkiP", "tax_id": 9913, "disease": "", "pathway": " (bta:326578); (R-BTA-2173795); (R-BTA-350054); (R-BTA-72163); (R-BTA-8941856)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in pre-mRNA splicing as component of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). Required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD., [UniProtKB, UniProtKB]; Involved in pre-mRNA splicing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity;GO:0005112 Notch binding;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016607 nuclear speck;GO:0016363 nuclear matrix;GO:0071007 U2-type catalytic step 2 spliceosome;GO:0008024 cyclin/CDK positive transcription elongation factor complex", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0071300 cellular response to retinoic acid", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1JQE0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIM1-1", "uniprot_id": [ { "id": "RN168_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIM1", "type": "external" } ], "mass": 65894.0, "length": 573, "protein_name": "E3 ubiquitin-protein ligase RNF168", "gene_name": "RNF168", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase RNF168", "refseq_ac": [ { "id": "NP_001069757", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069757", "type": "external" } ], "gene_names_uniprotkb": "RNF168", "gene_names_refseq": "RNF168", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF168; 2.3.2.27; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF168; RING-type E3 ubiquitin transferase RNF168", "tax_id": 9913, "disease": "", "pathway": " (bta:613812); (R-BTA-3108214); (R-BTA-5693565); (R-BTA-5693571); (R-BTA-5693607); (R-BTA-69473)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively)., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0042393 histone binding;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035861 site of double-strand break;GO:0000151 ubiquitin ligase complex;GO:0016604 nuclear body", "go_biological_process": "GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0010212 response to ionizing radiation;GO:0045739 positive regulation of DNA repair;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0IIM1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJ93-1", "uniprot_id": [ { "id": "CDC42_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJ93", "type": "external" } ], "mass": 21259.0, "length": 191, "protein_name": "Cell division control protein 42 homolog", "gene_name": "CDC42", "organism": "Bovine", "refseq_name": "cell division control protein 42 homolog", "refseq_ac": [ { "id": "NP_001039797", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039797", "type": "external" } ], "gene_names_uniprotkb": "CDC42", "gene_names_refseq": "CDC42", "protein_names_uniprotkb": "Cell division control protein 42 homolog; 3.6.5.2", "protein_names_refseq": "cell division control protein 42 homolog; cell division cycle 42 (GTP binding protein, 25kDa)", "tax_id": 9913, "disease": "", "pathway": " (bta:532712); (R-BTA-114604); (R-BTA-182971); (R-BTA-2029482); (R-BTA-389359); (R-BTA-3928662); (R-BTA-418885); (R-BTA-4420097); (R-BTA-525793); (R-BTA-5625970); (R-BTA-5626467); (R-BTA-5627123); (R-BTA-5663213); (R-BTA-5663220); (R-BTA-5687128); (R-BTA-8964616); (R-BTA-9013148); (R-BTA-9013404); (R-BTA-9013406); (R-BTA-9013408); (R-BTA-9013420); (R-BTA-9013423); (R-BTA-9013424); (R-BTA-983231)", "pathway_count": 24, "publication_count": 4, "publication_id_list": "12754216;17938223;17976566;1898776", "class_list": "", "function": "Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Shear-stimulated integrin dynamics induce polarized Cdc42 activity, which induces MTOC localization through the Par6-protein kinase Czeta complex., [RefSeq, PubMed]; These data are consistent with the idea that migrating corneal epithelial cells use a cdc42/rho 'switch' to sort vectoral cues, with cdc42 controlling electrotaxis and rho controlling contact guidance., [RefSeq, PubMed]; This study revealed a novel signaling pathway activated during M. avium subsp. paratuberculosis entry that links the product of MAP3464 gene to activation of Cdc42 in the host cell., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.2.1", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0003925 G protein activity;GO:0034191 apolipoprotein A-I receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite", "go_biological_process": "GO:0006897 endocytosis;GO:0006911 phagocytosis, engulfment;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0034329 cell junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q2KJ93-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMV0-1", "uniprot_id": [ { "id": "PEX5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMV0", "type": "external" } ], "mass": 70878.0, "length": 640, "protein_name": "Peroxisomal targeting signal 1 receptor", "gene_name": "PEX5", "organism": "Bovine", "refseq_name": "peroxisomal biogenesis factor 5", "refseq_ac": [ { "id": "NP_001039648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039648", "type": "external" } ], "gene_names_uniprotkb": "PEX5; PXR1", "gene_names_refseq": "PEX5", "protein_names_uniprotkb": "Peroxisomal targeting signal 1 receptor; PTS1 receptor; PTS1-BP; PTS1R; Peroxin-5; Peroxisomal C-terminal targeting signal import receptor; Peroxisome receptor 1", "protein_names_refseq": "PTS1 receptor; PTS1-BP; PTS1R; peroxin-5; peroxisomal C-terminal targeting signal import receptor; peroxisomal biogenesis factor 5; peroxisomal targeting signal 1 receptor; peroxisome receptor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:514832); (R-BTA-8866654); (R-BTA-9033241); (R-BTA-9664873)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "In addition to promoting peroxisomal translocation of proteins containing a PTS1 peroxisomal targeting signal, mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7. Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal. PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX5., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A1L572", "ec_number_list": [], "go_molecular_function": "GO:0033328 peroxisome membrane targeting sequence binding;GO:0031267 small GTPase binding;GO:0005052 peroxisome matrix targeting signal-1 binding;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005777 peroxisome;GO:0005778 peroxisomal membrane;GO:0005782 peroxisomal matrix;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0016561 protein import into peroxisome matrix, translocation;GO:0044721 protein import into peroxisome matrix, substrate release;GO:0051262 protein tetramerization;GO:0031333 negative regulation of protein-containing complex assembly;GO:0034614 cellular response to reactive oxygen species", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1RMV0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E50-1", "uniprot_id": [ { "id": "GBRA5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E50", "type": "external" } ], "mass": 52172.0, "length": 462, "protein_name": "Gamma-aminobutyric acid receptor subunit alpha-5", "gene_name": "GABRA5", "organism": "Bovine", "refseq_name": "gamma-aminobutyric acid receptor subunit alpha-5 precursor", "refseq_ac": [ { "id": "NP_001069312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069312", "type": "external" } ], "gene_names_uniprotkb": "GABRA5", "gene_names_refseq": "GABRA5", "protein_names_uniprotkb": "Gamma-aminobutyric acid receptor subunit alpha-5; GABA(A) receptor subunit alpha-5; GABAAR subunit alpha-5", "protein_names_refseq": "GABA(A) receptor subunit alpha-5; GABAAR subunit alpha-5; gamma-aminobutyric acid (GABA) A receptor, alpha 5; gamma-aminobutyric acid receptor subunit alpha-5 precursor; gamma-aminobutyric acid receptor subunit alpha-5; gamma-aminobutyric acid type A receptor alpha5 subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:523515); (R-BTA-977443)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing alpha-5/GABRA5 subunits are mainly extrasynaptic and contribute to the tonic GABAergic inhibition in the hippocampus (By similarity). Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0004890 GABA-A receptor activity;GO:0022851 GABA-gated chloride ion channel activity;GO:0099507 ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential", "go_cellular_component": "GO:0045211 postsynaptic membrane;GO:0098794 postsynapse;GO:0034707 chloride channel complex;GO:0032590 dendrite membrane;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:0007214 gamma-aminobutyric acid signaling pathway;GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic;GO:1904862 inhibitory synapse assembly;GO:0060384 innervation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08E50-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCY6-1", "uniprot_id": [ { "id": "MBOA7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCY6", "type": "external" } ], "mass": 52765.0, "length": 472, "protein_name": "Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7", "gene_name": "MBOAT7", "organism": "Bovine", "refseq_name": "membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7", "refseq_ac": [ { "id": "NP_001068620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068620", "type": "external" } ], "gene_names_uniprotkb": "MBOAT7; LENG4; OACT7", "gene_names_refseq": "LENG4; MBOAT7", "protein_names_uniprotkb": "Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7; 2.3.1.-; LPLAT 7; Leukocyte receptor cluster member 4; Lysophospholipid acyltransferase 7; Membrane-bound O-acyltransferase domain-containing protein 7; O-acyltransferase domain-containing protein 7", "protein_names_refseq": "LPLAT 7; O-acyltransferase domain-containing protein 7; leukocyte receptor cluster (LRC) member 4; leukocyte receptor cluster member 4; lysophospholipid acyltransferase 7; membrane-bound O-acyltransferase domain-containing protein 7; membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7", "tax_id": 9913, "disease": "", "pathway": " (bta:504236); (R-BTA-1482922)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle. Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell. In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" } ], "go_molecular_function": "GO:0071617 lysophospholipid acyltransferase activity;GO:0008374 O-acyltransferase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0006661 phosphatidylinositol biosynthetic process;GO:0021819 layer formation in cerebral cortex;GO:0090207 regulation of triglyceride metabolic process;GO:0030258 lipid modification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCY6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8F0-1", "uniprot_id": [ { "id": "NR4A1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8F0", "type": "external" } ], "mass": 64437.0, "length": 598, "protein_name": "Nuclear receptor subfamily 4 group A member 1", "gene_name": "NR4A1", "organism": "Bovine", "refseq_name": "nuclear receptor subfamily 4 group A member 1", "refseq_ac": [ { "id": "NP_001069379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069379", "type": "external" } ], "gene_names_uniprotkb": "NR4A1", "gene_names_refseq": "NR4A1", "protein_names_uniprotkb": "Nuclear receptor subfamily 4 group A member 1", "protein_names_refseq": "nuclear receptor subfamily 4 group A member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:528390); (R-BTA-383280)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16305752;21506113", "class_list": "", "function": "Identify the orphan nuclear receptor NR4A1 as a potential early response gene in FGF2 signaling and regulation of sprouty in bovine ovarian granulosa cells., [RefSeq, PubMed]; In the cytosol, upon its detection of both bacterial lipopolysaccharide (LPS) and NBRE-containing mitochondrial DNA released by GSDMD pores during pyroptosis, it promotes non-canonical NLRP3 inflammasome activation by stimulating association of NLRP3 and NEK7., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3' (By similarity). Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain (By similarity). Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA) (By similarity). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter (By similarity). May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration (By similarity). Plays a role in the vascular response to injury (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Orphan nuclear receptor. Binds the NGFI-B response element (NBRE) 5'-AAAGGTCA-3'. Binds 9-cis-retinoic acid outside of its ligand-binding (NR LBD) domain. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation. Regulates the inflammatory response in macrophages by regulating metabolic adaptations during inflammation, including repressing the transcription of genes involved in the citric acid cycle (TCA). Inhibits NF-kappa-B signaling by binding to low-affinity NF-kappa-B binding sites, such as at the IL2 promoter. May act concomitantly with NR4A2 in regulating the expression of delayed-early genes during liver regeneration. Plays a role in the vascular response to injury., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0035259 nuclear glucocorticoid receptor binding;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005667 transcription regulator complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006954 inflammatory response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q0V8F0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCK9-1", "uniprot_id": [ { "id": "VMP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCK9", "type": "external" } ], "mass": 46182.0, "length": 406, "protein_name": "Vacuole membrane protein 1", "gene_name": "VMP1", "organism": "Bovine", "refseq_name": "vacuole membrane protein 1", "refseq_ac": [ { "id": "NP_001068836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068836", "type": "external" } ], "gene_names_uniprotkb": "VMP1", "gene_names_refseq": "MIR21; TMEM49; VMP1", "protein_names_uniprotkb": "Vacuole membrane protein 1", "protein_names_refseq": "transmembrane protein 49; vacuole membrane protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:508631)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly. Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required. Modulates ER contacts with lipid droplets, mitochondria and endosomes. Plays an essential role in formation of cell junctions (By similarity). Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death. Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0034329 cell junction assembly;GO:0042953 lipoprotein transport;GO:0098609 cell-cell adhesion;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCK9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07537-1", "uniprot_id": [ { "id": "GALT1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q07537", "type": "external" } ], "mass": 64192.0, "length": 559, "protein_name": "Polypeptide N-acetylgalactosaminyltransferase 1", "gene_name": "GALNT1", "organism": "Bovine", "refseq_name": "polypeptide N-acetylgalactosaminyltransferase 1 precursor", "refseq_ac": [ { "id": "NP_803485", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803485", "type": "external" } ], "gene_names_uniprotkb": "GALNT1", "gene_names_refseq": "GALNT1; galNAc-T1", "protein_names_uniprotkb": "Polypeptide N-acetylgalactosaminyltransferase 1; 2.4.1.41; GalNAc-T1; Polypeptide GalNAc transferase 1; Protein-UDP acetylgalactosaminyltransferase 1; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1; pp-GaNTase 1", "protein_names_refseq": "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1); polypeptide GalNAc transferase 1; polypeptide N-acetylgalactosaminyltransferase 1 precursor; pp-GaNTase 1; protein-UDP acetylgalactosaminyltransferase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282241); (R-BTA-6811436); (R-BTA-913709)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "30573663;3082881;7685345;8360184;9359852", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:3082881, PubMed:7685345). Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 2, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 2, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 2, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 17, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" } ], "go_molecular_function": "GO:0030145 manganese ion binding;GO:0030246 carbohydrate binding;GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus;GO:0048471 perinuclear region of cytoplasm;GO:0032580 Golgi cisterna membrane;GO:0000139 Golgi membrane", "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0016266 protein O-linked glycosylation via N-acetyl-galactosamine", "synthesized_glycan_count": 7434, "hit_score": 0.8, "record_id": "Q07537-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.1000000000000.100.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79350-1", "uniprot_id": [ { "id": "OPRM_BOVIN", "url": "https://www.uniprot.org/uniprot/P79350", "type": "external" } ], "mass": 45028.0, "length": 401, "protein_name": "Mu-type opioid receptor", "gene_name": "OPRM1", "organism": "Bovine", "refseq_name": "mu-type opioid receptor", "refseq_ac": [ { "id": "NP_776833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776833", "type": "external" } ], "gene_names_uniprotkb": "OPRM1", "gene_names_refseq": "OPRM1", "protein_names_uniprotkb": "Mu-type opioid receptor; M-OR-1; MOR-1", "protein_names_refseq": "M-OR-1; MOR-1; mu-type opioid receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281958)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "10581406;22896890", "class_list": "", "function": "Analysis of solubilization of mu-opioid receptors enriched from bovine brain membranes, [RefSeq, PubMed]; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone (PubMed:10581406). Also activated by enkephalin peptides, such as Met-enkephalin or Met-enkephalin-Arg-Phe, with higher affinity for Met-enkephalin-Arg-Phe. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G protein complex and subsequent exchange of GDP for GTP in the G protein alpha subunit leading to dissociation of the G protein complex with the free GTP-bound G protein alpha and the G protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1, and to a lesser extent to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), phosphoinositide 3-kinase (PI3K) and regulation of NF-kappa-B. Also couples to adenylate cyclase stimulatory G alpha proteins. The selective temporal coupling to G proteins and subsequent signaling can be regulated by RGSZ proteins, such as RGS9, RGS17 and RGS4. Phosphorylation by members of the GPRK subfamily of Ser/Thr protein kinases and association with beta-arrestins is involved in short-term receptor desensitization. Beta-arrestins associate with the GPRK-phosphorylated receptor and uncouple it from the G protein thus terminating signal transduction. The phosphorylated receptor is internalized through endocytosis via clathrin-coated pits which involves beta-arrestins. The activation of the ERK pathway occurs either in a G protein-dependent or a beta-arrestin-dependent manner and is regulated by agonist-specific receptor phosphorylation. Acts as a class A G protein-coupled receptor (GPCR) which dissociates from beta-arrestin at or near the plasma membrane and undergoes rapid recycling. Receptor down-regulation pathways are varying with the agonist and occur dependent or independent of G protein coupling. Endogenous ligands induce rapid desensitization, endocytosis and recycling. Heterooligomerization with other GPCRs can modulate agonist binding, signaling and trafficking properties. Involved in neurogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031681 G-protein beta-subunit binding;GO:0004930 G protein-coupled receptor activity;GO:0001965 G-protein alpha-subunit binding;GO:0005245 voltage-gated calcium channel activity;GO:0038047 morphine receptor activity", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043204 perikaryon", "go_biological_process": "GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007197 adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:2000310 regulation of NMDA receptor activity", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P79350-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P79391-1", "uniprot_id": [ { "id": "OLR1_BOVIN", "url": "https://www.uniprot.org/uniprot/P79391", "type": "external" } ], "mass": 30892.0, "length": 270, "protein_name": "Oxidized low-density lipoprotein receptor 1", "gene_name": "OLR1", "organism": "Bovine", "refseq_name": "oxidized low-density lipoprotein receptor 1", "refseq_ac": [ { "id": "NP_776557", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776557", "type": "external" } ], "gene_names_uniprotkb": "OLR1; LOX1", "gene_names_refseq": "OLR1", "protein_names_uniprotkb": "Oxidized low-density lipoprotein receptor 1; LOX-1; Lectin-like oxLDL receptor 1; Lectin-like oxidized LDL receptor 1; Lectin-type oxidized LDL receptor 1; Ox-LDL receptor 1; bLOX-1", "protein_names_refseq": "BLOX1; LOX-1; bLOX-1; lectin-like oxLDL receptor 1; lectin-like oxidized LDL receptor 1; lectin-type oxidized LDL receptor 1; ox-LDL receptor 1; oxidised low density lipoprotein (lectin-like) receptor 1; oxidized low-density lipoprotein receptor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:281368)", "pathway_count": 1, "publication_count": 15, "publication_id_list": "10618423;10692464;10712396;10777555;11284714;11290792;11423119;11821070;24115745;24710763;25703423;28294375;29096854;9052782;9689115", "class_list": "", "function": "Bta-miR-370 has a negative regulatory effect on the OLR1 gene at both the gene and protein expression levels and has a role in lipid metabolism in bovine adipocytes, [RefSeq, PubMed]; Endothelial LOX-1 overexpression in an atherosclerosis-prone LDL receptor knockout mice impairs endothelial function, proving its importance in the development of atherosclerosis., [RefSeq, PubMed]; In the present study, we show that inhibition of LOX-1 leads to a rearrangement of ceramide from the basal membrane toward the Golgi apparatus, [RefSeq, PubMed]; Our data indicate that blocking the LOX-1 receptor signal pathway might be a promising way to improve steroid hormone concentrations in metabolically highly active female mammals, [RefSeq, PubMed]; Overexpression of LOX-1 leads to the attenuation of protective autophagy response in aortic endothelial cells., [RefSeq, PubMed]; Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 7, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0005041 low-density lipoprotein particle receptor activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0045121 membrane raft", "go_biological_process": "GO:0006954 inflammatory response;GO:0042157 lipoprotein metabolic process;GO:0007159 leukocyte cell-cell adhesion;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 1.6, "record_id": "P79391-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80012-1", "uniprot_id": [ { "id": "VWF_BOVIN", "url": "https://www.uniprot.org/uniprot/P80012", "type": "external" } ], "mass": 102599.0, "length": 937, "protein_name": "von Willebrand factor", "gene_name": "VWF", "organism": "Bovine", "refseq_name": "von Willebrand factor precursor", "refseq_ac": [ { "id": "NP_001192237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192237", "type": "external" } ], "gene_names_uniprotkb": "VWF; F8VWF", "gene_names_refseq": "VWF", "protein_names_uniprotkb": "von Willebrand factor; vWF", "protein_names_refseq": "von Willebrand factor precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:280958)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12871266;1707363;17408410;24139617;7588715;8566794;9165093", "class_list": "", "function": "Both the gpIb-VWF interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II)beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound, [RefSeq, PubMed]; Hemodynamic activation of vWF and increased plasma ADAMTS-13 may have contributed to reduced high-molecular-weight vWF multimers and impairment of the vWF-platelet aggregation pathway during mechanical circulatory support., [RefSeq, PubMed]; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q28011", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0005178 integrin binding;GO:0042802 identical protein binding;GO:0051087 protein-folding chaperone binding;GO:0005518 collagen binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0031012 extracellular matrix;GO:0033093 Weibel-Palade body", "go_biological_process": "GO:0007155 cell adhesion;GO:0007596 blood coagulation;GO:0030168 platelet activation;GO:0007599 hemostasis;GO:0031589 cell-substrate adhesion", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P80012-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80109-1", "uniprot_id": [ { "id": "PHLD_BOVIN", "url": "https://www.uniprot.org/uniprot/P80109", "type": "external" } ], "mass": 92602.0, "length": 839, "protein_name": "Phosphatidylinositol-glycan-specific phospholipase D", "gene_name": "GPLD1", "organism": "Bovine", "refseq_name": "phosphatidylinositol-glycan-specific phospholipase D precursor", "refseq_ac": [ { "id": "NP_777241", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777241", "type": "external" } ], "gene_names_uniprotkb": "GPLD1; PIGPLD", "gene_names_refseq": "GPLD1", "protein_names_uniprotkb": "Phosphatidylinositol-glycan-specific phospholipase D; 3.1.4.50; GPI-PLD; GPI-specific phospholipase D; Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D; PI-G PLD", "protein_names_refseq": "GPI-PLD; GPI-specific phospholipase D; PI-G PLD; glycoprotein phospholipase D; glycosyl-phosphatidylinositol-specific phospholipase D; phosphatidylinositol-glycan-specific phospholipase D precursor; phosphatidylinositol-glycan-specific phospholipase D", "tax_id": 9913, "disease": "", "pathway": " (bta:287025)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "12716481;1606959;2017684;2170394;26495903;9042330", "class_list": "", "function": "Hydrolyzes the inositol phosphate linkage of glycosylphosphatidylinositol (GPI)-anchored membrane proteins, thereby releasing them from the cell surface. Cleaves on the inositol side of the anchor, leaving the phosphate group attached to the membrane (PubMed:2017684, PubMed:2170394, PubMed:9042330). This release of GPI-anchored proteins can modulate diverse biological processes, including the activation of signaling pathways (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; PLD plays an important role in inflammatory responses and could be involved in a mechanism for the regulation of endothelial barrier function during hyperoxic lung injury, [RefSeq, PubMed]", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.50", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.50", "type": "external" } ], "go_molecular_function": "GO:0004621 glycosylphosphatidylinositol phospholipase D activity;GO:0017080 sodium channel regulator activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0034364 high-density lipoprotein particle", "go_biological_process": "GO:0002430 complement receptor mediated signaling pathway;GO:0071401 cellular response to triglyceride;GO:1900076 regulation of cellular response to insulin stimulus;GO:0006629 lipid metabolic process;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "P80109-1", "record_type": "protein", "filter_code": "0000000.0100101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80219-1", "uniprot_id": [ { "id": "DDN1_BOVIN", "url": "https://www.uniprot.org/uniprot/P80219", "type": "external" } ], "mass": 27556.0, "length": 251, "protein_name": "Duodenase-1", "gene_name": "BDMD1", "organism": "Bovine", "refseq_name": "duodenase-1 precursor", "refseq_ac": [ { "id": "NP_776721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776721", "type": "external" } ], "gene_names_uniprotkb": "BDMD1", "gene_names_refseq": "BDMD1; CTLA1; GZMB", "protein_names_uniprotkb": "Duodenase-1; 3.4.21.-; Duodenase I; Duodenum serine protease", "protein_names_refseq": "duodenase I; duodenase-1 precursor; duodenase-1; duodenum serine protease", "tax_id": 9913, "disease": "", "pathway": " (bta:281731)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "10944388;1425193;19817681;24798459;7867648;7867649", "class_list": "", "function": "Duodenase interacted with P1 variants of antichymotrypsin via a suicide mechanism with stoichiometry of the process SI = 1.2., [RefSeq, PubMed]; It is a cytotoxic genes in the endometrium and hightly expressed in the peri-implantation endometrium., [RefSeq, PubMed]; Protease which has both trypsin-like and chymotrypsin-like activities. Shows a preferential cleavage after Lys, Arg, Tyr, Phe, and Leu residues., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q9GLN2", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation;GO:0140507 granzyme-mediated programmed cell death signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P80219-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80221-1", "uniprot_id": [ { "id": "CXCL6_BOVIN", "url": "https://www.uniprot.org/uniprot/P80221", "type": "external" } ], "mass": 11589.0, "length": 112, "protein_name": "C-X-C motif chemokine 6", "gene_name": "CXCL6", "organism": "Bovine", "refseq_name": "C-X-C motif chemokine 6 precursor", "refseq_ac": [ { "id": "NP_776725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776725", "type": "external" } ], "gene_names_uniprotkb": "CXCL6; GCP2; SCYB6", "gene_names_refseq": "CXCL5; CXCL6; GCP-2; GCP2; SCYB6", "protein_names_uniprotkb": "C-X-C motif chemokine 6; GCP-2; Granulocyte chemotactic protein 2; Small-inducible cytokine B6", "protein_names_refseq": "C-X-C motif chemokine 6 precursor; C-X-C motif chemokine 6; chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2); granulocyte chemotactic protein 2; inducible cytokine subfamily B (Cys-X-Cys), member 6; small-inducible cytokine B6", "tax_id": 9913, "disease": "", "pathway": " (bta:281735); (R-BTA-380108); (R-BTA-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "8399143", "class_list": "", "function": "Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7) (By similarity)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJH0;Q9GKP5", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006954 inflammatory response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0071222 cellular response to lipopolysaccharide;GO:0042742 defense response to bacterium;GO:0042119 neutrophil activation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P80221-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80311-1", "uniprot_id": [ { "id": "PPIB_BOVIN", "url": "https://www.uniprot.org/uniprot/P80311", "type": "external" } ], "mass": 23744.0, "length": 216, "protein_name": "Peptidyl-prolyl cis-trans isomerase B", "gene_name": "PPIB", "organism": "Bovine", "refseq_name": "peptidyl-prolyl cis-trans isomerase B precursor", "refseq_ac": [ { "id": "NP_776577", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776577", "type": "external" } ], "gene_names_uniprotkb": "PPIB", "gene_names_refseq": "PPIB", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase B; 5.2.1.8; Cyclophilin B; PPIase B; Rotamase B; S-cyclophilin; SCYLP", "protein_names_refseq": "PPIase B; S-cyclophilin; SCYLP; cyclophilin B; peptidyl-prolyl cis-trans isomerase B precursor; peptidyl-prolyl cis-trans isomerase B; rotamase B", "tax_id": 9913, "disease": "", "pathway": " (bta:281419); (R-BTA-1650814)", "pathway_count": 2, "publication_count": 4, "publication_id_list": "16305752;28619100;8010972;8013656", "class_list": "", "function": "Cellular CypB was confirmed to be significantly up-regulated in the Orf virus-infected MDBK cells at an early phase of infection, which could effectively facilitate the replication of Orf virus. Publication Status: Online-Only, [RefSeq, PubMed]; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5E9F4", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "1.14.11.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.7", "type": "external" } ], "go_molecular_function": "GO:0070063 RNA polymerase binding;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen;GO:0048471 perinuclear region of cytoplasm;GO:0042470 melanosome", "go_biological_process": "GO:0044829 host-mediated activation of viral genome replication;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:0060348 bone development;GO:0040018 positive regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P80311-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P80929-1", "uniprot_id": [ { "id": "ANG2_BOVIN", "url": "https://www.uniprot.org/uniprot/P80929", "type": "external" } ], "mass": 14522.0, "length": 123, "protein_name": "Angiogenin-2", "gene_name": "ANG2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ANG2", "gene_names_refseq": "", "protein_names_uniprotkb": "Angiogenin-2; 3.1.27.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "9266695", "class_list": "", "function": "Binds tightly to placental ribonuclease inhibitor and has very low ribonuclease activity (PubMed:9266695). Has potent angiogenic activity (PubMed:9266695). Angiogenin induces vascularization of normal and malignant tissues (PubMed:9266695). Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs (PubMed:9266695)., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004519 endonuclease activity;GO:0004540 RNA nuclease activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005730 nucleolus;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0001525 angiogenesis;GO:0030154 cell differentiation;GO:0050830 defense response to Gram-positive bacterium;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P80929-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.1000000000000.100.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81265-1", "uniprot_id": [ { "id": "PIGR_BOVIN", "url": "https://www.uniprot.org/uniprot/P81265", "type": "external" } ], "mass": 82435.0, "length": 757, "protein_name": "Polymeric immunoglobulin receptor", "gene_name": "PIGR", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PIGR", "gene_names_refseq": "", "protein_names_uniprotkb": "Polymeric immunoglobulin receptor; PIgR; Poly-Ig receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281401)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7590352;7880445", "class_list": "", "function": "Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment., [UniProtKB, UniProtKB]; Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens. On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0071751 secretory IgA immunoglobulin complex", "go_biological_process": "GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor;GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P81265-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81287-1", "uniprot_id": [ { "id": "ANXA5_BOVIN", "url": "https://www.uniprot.org/uniprot/P81287", "type": "external" } ], "mass": 36089.0, "length": 321, "protein_name": "Annexin A5", "gene_name": "ANXA5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ANXA5; ANX5", "gene_names_refseq": "", "protein_names_uniprotkb": "Annexin A5; Anchorin CII; Annexin V; Annexin-5; CPB-I; Calphobindin I; Endonexin II; Lipocortin V; PAP-I; Placental anticoagulant protein 4; Placental anticoagulant protein I; Thromboplastin inhibitor; VAC-alpha; Vascular anticoagulant-alpha", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1420335;16305752", "class_list": "", "function": "This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZCH7;Q5E9B9", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding;GO:0005544 calcium-dependent phospholipid binding;GO:0001786 phosphatidylserine binding", "go_cellular_component": "GO:0005622 intracellular anatomical structure;GO:0005737 cytoplasm;GO:0042383 sarcolemma;GO:0012506 vesicle membrane", "go_biological_process": "GO:0007596 blood coagulation;GO:0050819 negative regulation of coagulation;GO:0051283 negative regulation of sequestering of calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P81287-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81401-1", "uniprot_id": [ { "id": "VIP_BOVIN", "url": "https://www.uniprot.org/uniprot/P81401", "type": "external" } ], "mass": 19165.0, "length": 170, "protein_name": "VIP peptides", "gene_name": "VIP", "organism": "Bovine", "refseq_name": "VIP peptides precursor", "refseq_ac": [ { "id": "NP_776395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776395", "type": "external" } ], "gene_names_uniprotkb": "VIP", "gene_names_refseq": "VIP", "protein_names_uniprotkb": "VIP peptides; Peptide histidine isoleucinamide 27; Vasoactive intestinal polypeptide", "protein_names_refseq": "VIP peptides precursor; VIP peptides", "tax_id": 9913, "disease": "", "pathway": " (bta:280956); (R-BTA-418555); (R-BTA-420092)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "12097482;18619673;520589;6548446", "class_list": "", "function": "Data show that PKA and PKC pathways are involved in the differential regulation of production of the neuropeptides (Met)enkephalin, galanin, somatostatin, NPY, and VIP., [RefSeq, PubMed]; PHM-27 is a bioactive form from proteolysis of the same precursor protein, that causes vasodilation. It is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin., [UniProtKB, UniProtKB]; VIP is a neuropeptide involved in a diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VPR1) and VIP receptor 2 (VPR2). Abundantly expressed throughout the CNS and peripheral nervous systems where they primarily exert neuroprotective and immune modulatory roles (By similarity). Also causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VC69;Q8MI77", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0051428 peptide hormone receptor binding;GO:0031891 type 1 vasoactive intestinal polypeptide receptor binding;GO:0031892 type 2 vasoactive intestinal polypeptide receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0043005 neuron projection", "go_biological_process": "GO:0048242 epinephrine secretion;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0048255 mRNA stabilization;GO:0032880 regulation of protein localization;GO:0045732 positive regulation of protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "P81401-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P81947-1", "uniprot_id": [ { "id": "TBA1B_BOVIN", "url": "https://www.uniprot.org/uniprot/P81947", "type": "external" } ], "mass": 50152.0, "length": 451, "protein_name": "Tubulin alpha-1B chain", "gene_name": "", "organism": "Bovine", "refseq_name": "tubulin alpha-1B chain", "refseq_ac": [ { "id": "NP_001108328", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108328", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "TUBA1B", "protein_names_uniprotkb": "Tubulin alpha-1B chain; 3.6.5.-; Alpha-tubulin ubiquitous; Tubulin K-alpha-1; Tubulin alpha-ubiquitous chain", "protein_names_refseq": "tubulin alpha-1B chain; tubulin, alpha, ubiquitous", "tax_id": 9913, "disease": "", "pathway": " (bta:539882)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "2207090;41018975;6504138;7704569;9571153", "class_list": "", "function": "Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:2207090, PubMed:6504138, PubMed:7704569). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin (PubMed:2207090, PubMed:6504138, PubMed:7704569)., [UniProtKB, PubMed, PubMed, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6H700", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "6.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.25", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005929 cilium;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0030182 neuron differentiation;GO:0000226 microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "P81947-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84227-1", "uniprot_id": [ { "id": "H32_BOVIN", "url": "https://www.uniprot.org/uniprot/P84227", "type": "external" } ], "mass": 15388.0, "length": 136, "protein_name": "Histone H3.2", "gene_name": "", "organism": "Bovine", "refseq_name": "histone H3.2", "refseq_ac": [ { "id": "NP_001160041", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160041", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "H3C13", "protein_names_uniprotkb": "Histone H3.2", "protein_names_refseq": "histone H3.2", "tax_id": 9913, "disease": "", "pathway": " (bta:115945173); (bta:504599); (bta:788077); (R-BTA-1266695); (R-BTA-201722); (R-BTA-212300); (R-BTA-2299718); (R-BTA-2559580); (R-BTA-2559582); (R-BTA-3214815); (R-BTA-3214841); (R-BTA-3214842); (R-BTA-3214847); (R-BTA-3214858); (R-BTA-3247509); (R-BTA-427359); (R-BTA-427413); (R-BTA-5250924); (R-BTA-5578749); (R-BTA-5625886); (R-BTA-68616); (R-BTA-73728); (R-BTA-73772); (R-BTA-8936459); (R-BTA-9018519); (R-BTA-9764725); (R-BTA-983231); (R-BTA-9841922); (R-BTA-9843940); (R-BTA-9843970); (R-BTA-9909649); (R-BTA-9940951); (R-BTA-9943411); (R-BTA-9943962); (R-BTA-9970672)", "pathway_count": 35, "publication_count": 3, "publication_id_list": "10464286;1167550;5016641", "class_list": "", "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "P02295;P02297;P16105;P17269;P17320", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin", "go_cellular_component": "GO:0005634 nucleus;GO:0000786 nucleosome", "go_biological_process": "GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "P84227-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P84466-1", "uniprot_id": [ { "id": "LSS_BOVIN", "url": "https://www.uniprot.org/uniprot/P84466", "type": "external" } ], "mass": 83184.0, "length": 732, "protein_name": "Lanosterol synthase", "gene_name": "LSS", "organism": "Bovine", "refseq_name": "lanosterol synthase", "refseq_ac": [ { "id": "NP_001040029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040029", "type": "external" } ], "gene_names_uniprotkb": "LSS", "gene_names_refseq": "LSS", "protein_names_uniprotkb": "Lanosterol synthase; 2,3-epoxysqualene--lanosterol cyclase; 5.4.99.7; OSC; Oxidosqualene--lanosterol cyclase", "protein_names_refseq": "2,3-epoxysqualene--lanosterol cyclase; OSC; lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); lanosterol synthase; oxidosqualene lanosterol cyclase", "tax_id": 9913, "disease": "", "pathway": " (bta:615906)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "14678783", "class_list": "", "function": "Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:14678783). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q2EMV7", "ec_number_list": [ { "id": "5.4.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-", "type": "external" }, { "id": "5.4.99.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.7", "type": "external" } ], "go_molecular_function": "GO:0000250 lanosterol synthase activity", "go_cellular_component": "GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0006694 steroid biosynthetic process;GO:0016104 triterpenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "P84466-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98072-1", "uniprot_id": [ { "id": "ENTK_BOVIN", "url": "https://www.uniprot.org/uniprot/P98072", "type": "external" } ], "mass": 114887.0, "length": 1035, "protein_name": "Enteropeptidase", "gene_name": "TMPRSS15", "organism": "Bovine", "refseq_name": "enteropeptidase precursor", "refseq_ac": [ { "id": "NP_776864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776864", "type": "external" } ], "gene_names_uniprotkb": "TMPRSS15; ENTK; PRSS7", "gene_names_refseq": "PRSS7; TMPRSS15", "protein_names_uniprotkb": "Enteropeptidase; 3.4.21.9; Enterokinase; Serine protease 7; Transmembrane protease serine 15", "protein_names_refseq": "enteropeptidase precursor; enteropeptidase; protease, serine, 7 (enterokinase); serine protease 7; transmembrane protease, serine 15", "tax_id": 9913, "disease": "", "pathway": " (bta:282009)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10493881;1799406;18323639;8052624;8226855", "class_list": "", "function": "Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Substrate specificities of porcine and bovine enteropeptidases were investigated using the peptide Val-(Asp)(4)-Lys-Ile-Val-Gly and its various analogs with mutations in the (Asp)(4)-Lys sequence as substrates, [RefSeq, PubMed]", "predicted_glycosites": 22, "predicted_n_glycosites": 20, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 1, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 22, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0008236 serine-type peptidase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0016485 protein processing;GO:0032023 trypsinogen activation;GO:0044256 protein digestion;GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "P98072-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "P98131-1", "uniprot_id": [ { "id": "LYAM1_BOVIN", "url": "https://www.uniprot.org/uniprot/P98131", "type": "external" } ], "mass": 41971.0, "length": 370, "protein_name": "L-selectin", "gene_name": "SELL", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SELL", "gene_names_refseq": "", "protein_names_uniprotkb": "L-selectin; CD62 antigen-like family member L; LAM-1; LECAM1; Leukocyte adhesion molecule 1; Leukocyte-endothelial cell adhesion molecule 1; Lymph node homing receptor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281485)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1371468;7694420", "class_list": "", "function": "Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0005509 calcium ion binding;GO:0033691 sialic acid binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0034097 response to cytokine;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0050901 leukocyte tethering or rolling;GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "P98131-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q01107-1", "uniprot_id": [ { "id": "DSC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q01107", "type": "external" } ], "mass": 99648.0, "length": 893, "protein_name": "Desmocollin-1", "gene_name": "DSC1", "organism": "Bovine", "refseq_name": "desmocollin-1 precursor", "refseq_ac": [ { "id": "NP_776469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776469", "type": "external" } ], "gene_names_uniprotkb": "DSC1", "gene_names_refseq": "DG2/DG3; DG2DG3; DSC1; dg3", "protein_names_uniprotkb": "Desmocollin-1; DG2/DG3; Desmosomal glycoprotein 2/3", "protein_names_refseq": "desmocollin-1 precursor; desmosomal glycoprotein 2 (dg2); desmosomal glycoprotein 2/3", "tax_id": 9913, "disease": "", "pathway": " (bta:281127)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "1916068;2010468;2034686;2120245;2277091", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for desmosome adhesion strength between the granular layers of the epidermis, as a result moderates epidermal proliferation and differentiation (By similarity). Is therefore required to maintain postnatal epidermal barrier function and normal hair follicle morphology into adulthood (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q28095", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005912 adherens junction;GO:0016020 membrane;GO:0030027 lamellipodium;GO:0045177 apical part of cell", "go_biological_process": "GO:0016477 cell migration;GO:0061436 establishment of skin barrier;GO:0050680 negative regulation of epithelial cell proliferation;GO:0000902 cell morphogenesis;GO:0007416 synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q01107-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02375-1", "uniprot_id": [ { "id": "NDUS4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02375", "type": "external" } ], "mass": 19812.0, "length": 175, "protein_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial", "gene_name": "NDUFS4", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor", "refseq_ac": [ { "id": "NP_786994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_786994", "type": "external" } ], "gene_names_uniprotkb": "NDUFS4", "gene_names_refseq": "NDUFS4", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; CI-18 kDa; CI-AQDQ; Complex I-18 kDa; Complex I-AQDQ; NADH-ubiquinone oxidoreductase 18 kDa subunit", "protein_names_refseq": "CI-18 kDa; CI-AQDQ; NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase); NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial precursor; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial; NADH-ubiquinone oxidoreductase 18 kDa subunit; complex I-18 kDa; complex I-AQDQ", "tax_id": 9913, "disease": "", "pathway": " (bta:327680); (R-BTA-611105); (R-BTA-6799198)", "pathway_count": 3, "publication_count": 5, "publication_id_list": "10852722;1518044;18721790;20433953;8603710", "class_list": "", "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed, PubMed]; Two-dimensional gel electrophoresis, (32)P labelling and immunodetection show that 'in vitro' PKA phosphorylates the serine in the C-terminus of the NDUFS4 subunit in isolated bovine complex I., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I", "go_biological_process": "GO:0032981 mitochondrial respiratory chain complex I assembly;GO:0007420 brain development;GO:0051591 response to cAMP;GO:0072593 reactive oxygen species metabolic process;GO:0022904 respiratory electron transport chain", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q02375-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q02399-1", "uniprot_id": [ { "id": "CDK5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q02399", "type": "external" } ], "mass": 33288.0, "length": 292, "protein_name": "Cyclin-dependent kinase 5", "gene_name": "CDK5", "organism": "Bovine", "refseq_name": "cyclin-dependent kinase 5", "refseq_ac": [ { "id": "NP_776442", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776442", "type": "external" } ], "gene_names_uniprotkb": "CDK5; CDKN5; PSSALRE", "gene_names_refseq": "CDK5", "protein_names_uniprotkb": "Cyclin-dependent kinase 5; 2.7.11.1; Cell division protein kinase 5; Cyclin-dependent-like kinase 5; PDPK; Proline-directed protein kinase 33 kDa subunit; Serine/threonine-protein kinase PSSALRE; TPKII catalytic subunit; Tau protein kinase II catalytic subunit", "protein_names_refseq": "PDPK; TPKII catalytic subunit; cell division protein kinase 5; cyclin-dependent kinase 5; cyclin-dependent-like kinase 5; proline-directed protein kinase 33 kDa subunit; serine/threonine-protein kinase PSSALRE; tau protein kinase II catalytic subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:281066); (R-BTA-180024); (R-BTA-399956); (R-BTA-6804756); (R-BTA-9841922)", "pathway_count": 5, "publication_count": 4, "publication_id_list": "1464604;17202132;8253190;8621400", "class_list": "", "function": "Data indicate that PP1alpha is a downstream target of the NGF/Egr-1/Cdk5 pathway during NGF-induced differentiation of PC12 cells and suggest that PP1 phosphorylation promotes neuronal differentiation, [RefSeq, PubMed]; Proline-directed serine/threonine-protein kinase essential for neuronal cell cycle arrest and differentiation and may be involved in apoptotic cell death in neuronal diseases by triggering abortive cell cycle re-entry. Interacts with D1 and D3-type G1 cyclins. Phosphorylates SRC, NOS3, VIM/vimentin, p35/CDK5R1, MEF2A, SIPA1L1, SH3GLB1, PXN, PAK1, MCAM/MUC18, SEPT5, SYN1, DNM1, AMPH, SYNJ1, CDK16, RAC1, RHOA, CDC42, TONEBP/NFAT5, MAPT/TAU, MAP1B, histone H1, p53/TP53, HDAC1, APEX1, PTK2/FAK1, huntingtin/HTT, ATM, MAP2, NEFH and NEFM. Regulates several neuronal development and physiological processes including neuronal survival, migration and differentiation, axonal and neurite growth, synaptogenesis, oligodendrocyte differentiation, synaptic plasticity and neurotransmission, by phosphorylating key proteins. Negatively regulates the CACNA1B/CAV2.2 -mediated Ca(2+) release probability at hippocampal neuronal soma and synaptic terminals (By similarity). Activated by interaction with CDK5R1 (p35) and CDK5R2 (p39), especially in postmitotic neurons, and promotes CDK5R1 (p35) expression in an autostimulation loop. Phosphorylates many downstream substrates such as Rho and Ras family small GTPases (e.g. PAK1, RAC1, RHOA, CDC42) or microtubule-binding proteins (e.g. MAPT/TAU, MAP2, MAP1B), and modulates actin dynamics to regulate neurite growth and/or spine morphogenesis. Also phosphorylates exocytosis associated proteins such as MCAM/MUC18, SEPT5, SYN1, and CDK16/PCTAIRE1 as well as endocytosis associated proteins such as DNM1, AMPH and SYNJ1 at synaptic terminals. In the mature central nervous system (CNS), regulates neurotransmitter movements by phosphorylating substrates associated with neurotransmitter release and synapse plasticity; synaptic vesicle exocytosis, vesicles fusion with the presynaptic membrane, and endocytosis. Promotes cell survival by activating anti-apoptotic proteins BCL2 and STAT3, and negatively regulating of JNK3/MAPK10 activity. Phosphorylation of p53/TP53 in response to genotoxic and oxidative stresses enhances its stabilization by preventing ubiquitin ligase-mediated proteasomal degradation, and induces transactivation of p53/TP53 target genes, thus regulating apoptosis. Phosphorylation of p35/CDK5R1 enhances its stabilization by preventing calpain-mediated proteolysis producing p25/CDK5R1 and avoiding ubiquitin ligase-mediated proteasomal degradation. During aberrant cell-cycle activity and DNA damage, p25/CDK5 activity elicits cell-cycle activity and double-strand DNA breaks that precedes neuronal death by deregulating HDAC1. DNA damage triggered phosphorylation of huntingtin/HTT in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity. Phosphorylation of PXN reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation. Negative regulator of Wnt/beta-catenin signaling pathway. Activator of the GAIT (IFN-gamma-activated inhibitor of translation) pathway, which suppresses expression of a post-transcriptional regulon of proinflammatory genes in myeloid cells; phosphorylates the linker domain of glutamyl-prolyl tRNA synthetase (EPRS) in a IFN-gamma-dependent manner, the initial event in assembly of the GAIT complex. Phosphorylation of SH3GLB1 is required for autophagy induction in starved neurons. Phosphorylation of TONEBP/NFAT5 in response to osmotic stress mediates its rapid nuclear localization. MEF2 is inactivated by phosphorylation in nucleus in response to neurotoxin, thus leading to neuronal apoptosis. APEX1 AP-endodeoxyribonuclease is repressed by phosphorylation, resulting in accumulation of DNA damage and contributing to neuronal death. NOS3 phosphorylation down regulates NOS3-derived nitrite (NO) levels. SRC phosphorylation mediates its ubiquitin-dependent degradation and thus leads to cytoskeletal reorganization. May regulate endothelial cell migration and angiogenesis via the modulation of lamellipodia formation. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0VCN5;Q6LBE2", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.3.1.286", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.286", "type": "external" }, { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0030549 acetylcholine receptor activator activity;GO:0050321 tau-protein kinase activity;GO:0016301 kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0007409 axonogenesis;GO:0016477 cell migration;GO:0031175 neuron projection development;GO:0051301 cell division;GO:0051402 neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q02399-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03041-1", "uniprot_id": [ { "id": "CNGA2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q03041", "type": "external" } ], "mass": 76014.0, "length": 663, "protein_name": "Cyclic nucleotide-gated channel alpha-2", "gene_name": "CNGA2", "organism": "Bovine", "refseq_name": "cyclic nucleotide-gated channel alpha-2", "refseq_ac": [ { "id": "NP_001001139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001139", "type": "external" } ], "gene_names_uniprotkb": "CNGA2; CNCG2", "gene_names_refseq": "CNGA2; CNGa3; OCNC1", "protein_names_uniprotkb": "Cyclic nucleotide-gated channel alpha-2; CNCalpha3; CNG channel alpha-2; CNG-2; CNG2; CNGa3; Cyclic nucleotide-gated channel alpha 3; OCNC1; Olfactory cyclic nucleotide-gated channel subunit 1", "protein_names_refseq": "CNCalpha3; CNG channel alpha-2; CNG-2; CNG2; cAMP-gated channel; cyclic nucleotide gated channel alpha 2; cyclic nucleotide-gated cation channel 2; cyclic nucleotide-gated channel alpha 3; cyclic nucleotide-gated channel alpha-2; cyclic nucleotide-gated olfactory channel; olfactory cyclic nucleotide-gated channel subunit 1", "tax_id": 9913, "disease": "", "pathway": " (bta:407172)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "11764791;15803393;1699793;18292397;18621055;9878057", "class_list": "", "function": "CNGA2 channels play a key role in adenosine-induced endothelial Ca(2+) influx and vasorelaxation, [RefSeq, PubMed]; Mediates epinephrine-induced endothelial calcium influx and subsequent vascular dilation., [RefSeq, PubMed]; Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005216 monoatomic ion channel activity;GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0005223 intracellularly cGMP-activated cation channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0017071 intracellular cyclic nucleotide activated cation channel complex;GO:0098804 non-motile cilium membrane", "go_biological_process": "GO:0006816 calcium ion transport;GO:0098655 monoatomic cation transmembrane transport;GO:0006813 potassium ion transport;GO:0007608 sensory perception of smell;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q03041-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q03763-1", "uniprot_id": [ { "id": "DSG1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q03763", "type": "external" } ], "mass": 112243.0, "length": 1043, "protein_name": "Desmoglein-1", "gene_name": "DSG1", "organism": "Bovine", "refseq_name": "desmoglein-1 precursor", "refseq_ac": [ { "id": "NP_776470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776470", "type": "external" } ], "gene_names_uniprotkb": "DSG1", "gene_names_refseq": "DSG1", "protein_names_uniprotkb": "Desmoglein-1; DG1; DGI; Desmosomal glycoprotein 1; Pemphigus foliaceus antigen", "protein_names_refseq": "DG1; DGI; desmoglein-1 precursor; desmosomal glycoprotein 1; pemphigus foliaceus antigen", "tax_id": 9913, "disease": "", "pathway": " (bta:281131)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1702628;1706270;1935985;8294446", "class_list": "", "function": "A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Promotes differentiation of keratinocytes via interaction with ERBIN. Reduces activation of RAS/ERK signaling pathways in keratinocytes via promoting ERBIN localization to the cell membrane and its interaction with SHOC2, this competitively reduces the formation of RAS-SHOC2 ERK-activating complexes (By similarity). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (By similarity). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (By similarity). Critical for epidermal integrity and barrier function of the skin (By similarity). Required for esophageal epithelial barrier integrity and correct intercellular spacing in differentiated esophageal epithelium (By similarity). Required for recovery of epidermal architecture and correct expression of differentiation markers following UVB exposure (By similarity). May also be required for OCLN involvement in tight junctions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 1, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 1, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 1, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q9TS15", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0045295 gamma-catenin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030057 desmosome", "go_biological_process": "GO:0098609 cell-cell adhesion;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q03763-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.1000000011000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q04790-1", "uniprot_id": [ { "id": "INAR1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q04790", "type": "external" } ], "mass": 63819.0, "length": 560, "protein_name": "Interferon alpha/beta receptor 1", "gene_name": "IFNAR1", "organism": "Bovine", "refseq_name": "interferon alpha/beta receptor 1 precursor", "refseq_ac": [ { "id": "NP_776977", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776977", "type": "external" } ], "gene_names_uniprotkb": "IFNAR1; IFNAR", "gene_names_refseq": "IFNAR1", "protein_names_uniprotkb": "Interferon alpha/beta receptor 1; IFN-R-1; IFN-alpha/beta receptor 1; Type I interferon receptor 1", "protein_names_refseq": "IFN-R-1; IFN-alpha-REC; IFN-alpha/beta receptor 1; interferon alpha/beta receptor 1 precursor; interferon alpha/beta receptor 1; interferon, alpha; interferon-alpha/beta receptor alpha chain; receptor; type I interferon receptor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:282257); (R-BTA-909733); (R-BTA-912694)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1446745;18937499;35907379;8318540", "class_list": "", "function": "Mutation of the IFNAR-1 receptor binding site of human IFN-alpha2 generates type I IFN competitive antagonists., [RefSeq, PubMed]; Specific activation of embryonic IFNAR1 and endometrial IFNAR2 induced by embryonic IFNtau directs normal uterine fate for bovine early implantation., [RefSeq, PubMed]; Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa) (PubMed:8318540). Type I interferon binding activates the JAK-STAT signaling cascade, resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response (By similarity). Mechanistically, type I interferon-binding brings the IFNAR1 and IFNAR2 subunits into close proximity with one another, driving their associated Janus kinases (JAKs) (TYK2 bound to IFNAR1 and JAK1 bound to IFNAR2) to cross-phosphorylate one another (By similarity). The activated kinases phosphorylate specific tyrosine residues on the intracellular domains of IFNAR1 and IFNAR2, forming docking sites for the STAT transcription factors (By similarity). STAT proteins are then phosphorylated by the JAKs, promoting their translocation into the nucleus to regulate expression of interferon-regulated genes (By similarity). Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 9, "predicted_n_glycosites": 9, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 9, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004905 type I interferon receptor activity;GO:0019962 type I interferon binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0009893 positive regulation of metabolic process;GO:0032496 response to lipopolysaccharide;GO:0060337 type I interferon-mediated signaling pathway;GO:0009615 response to virus", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q04790-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05037-1", "uniprot_id": [ { "id": "KCNA4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05037", "type": "external" } ], "mass": 73513.0, "length": 660, "protein_name": "Potassium voltage-gated channel subfamily A member 4", "gene_name": "KCNA4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KCNA4", "gene_names_refseq": "", "protein_names_uniprotkb": "Potassium voltage-gated channel subfamily A member 4; BAK4; Voltage-gated potassium channel subunit Kv1.4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "1505668;8110763", "class_list": "", "function": "Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:1505668). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (By similarity). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed:1505668). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (By similarity)., [UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005251 delayed rectifier potassium channel activity;GO:0030955 potassium ion binding;GO:0005249 voltage-gated potassium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043197 dendritic spine;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0001508 action potential;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q05037-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05204-1", "uniprot_id": [ { "id": "LAMP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05204", "type": "external" } ], "mass": 44153.0, "length": 409, "protein_name": "Lysosome-associated membrane glycoprotein 1", "gene_name": "LAMP1", "organism": "Bovine", "refseq_name": "lysosome-associated membrane glycoprotein 1 precursor", "refseq_ac": [ { "id": "NP_001068592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068592", "type": "external" } ], "gene_names_uniprotkb": "LAMP1", "gene_names_refseq": "LAMP1", "protein_names_uniprotkb": "Lysosome-associated membrane glycoprotein 1; CD107 antigen-like family member A; Chromaffin granule-associated membrane glycoprotein IIA; LAMP-1; Lysosome-associated membrane protein 1", "protein_names_refseq": "CD107 antigen-like family member A; LAMP-1; chromaffin granule-associated membrane glycoprotein IIA; glycoprotein IIa; lysosome-associated membrane glycoprotein 1 precursor; lysosome-associated membrane glycoprotein 1; lysosome-associated membrane protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:281897); (R-BTA-6798695)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "8496169", "class_list": "", "function": "Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins., [UniProtKB, UniProtKB]", "predicted_glycosites": 19, "predicted_n_glycosites": 18, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 19, "binding_glycan_count": 0, "secondary_ac_list": "A2VE82;A5D7M2;Q17QC6", "ec_number_list": [], "go_molecular_function": "GO:0008200 ion channel inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0072594 establishment of protein localization to organelle;GO:0050821 protein stabilization;GO:0007042 lysosomal lumen acidification", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q05204-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05688-1", "uniprot_id": [ { "id": "IGF1R_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05688", "type": "external" } ], "mass": 72511.0, "length": 640, "protein_name": "Insulin-like growth factor 1 receptor", "gene_name": "IGF1R", "organism": "Bovine", "refseq_name": "insulin-like growth factor 1 receptor precursor", "refseq_ac": [ { "id": "NP_001231541", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231541", "type": "external" } ], "gene_names_uniprotkb": "IGF1R", "gene_names_refseq": "IGF1R; IGFR1", "protein_names_uniprotkb": "Insulin-like growth factor 1 receptor; 2.7.10.1; IGF-I receptor; Insulin-like growth factor I receptor", "protein_names_refseq": "IGF-I receptor; insulin-like growth factor 1 receptor precursor; insulin-like growth factor I receptor; insulin-like growth factor receptor type 1", "tax_id": 9913, "disease": "", "pathway": " (bta:281848)", "pathway_count": 1, "publication_count": 7, "publication_id_list": "12782408;1662995;17360960;24210909;26031184;27112238;29926362", "class_list": "", "function": "A total of 1169 cows of 4 pure breeds (Polish Holstein Friesian, Montbeliarde, Jersey and Holstein Friesian) were genotyped. The T (IGF1R/e2/MspI) and G (IGF1R/e2/TaqI) alleles were found to be prevalent. 3 combinations of genotypes (TT/GG, TT/AG and CT/GG) were associated with the highest productivity (milk, protein and fat yields) among the breeds studied, as opposed to individuals carrying the worst CC/AA combination., [RefSeq, PubMed]; Granulosa cell clustering is accompanied by marked increases in FSHr, IGF-1r, and p450 arom expression, and precedes induction and subsequent peak E2 production, [RefSeq, PubMed]; Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R. IGF1 exerts inhibiting activities on JNK activation via phosphorylation and inhibition of MAP3K5/ASK1, which is able to directly associate with the IGF1R (By similarity). When present in a hybrid receptor with INSR, binds IGF1 (By similarity)., [UniProtKB]; Results of the present study showed, for the first time, that the polymorphism in IGF1R is associated with superovulation traits, and indicated that the IGFIR gene can be used as a potential marker for donor selection., [RefSeq, PubMed]; Rs110343126 associated with fertility in hot-humid climate, [RefSeq, PubMed]; Study determined IGFR1 and PAPP-A expression both in follicles at different stages of development and in ovarian cysts; data indicate that animals with cystic ovarian disease (COD) have an altered regulation of the IGF system in the ovary and thus allow postulating IGFR1 expression and PAPP-A secretion as a modulator of IGF1 in cattle with COD, [RefSeq, PubMed]; Treatment with IGF1R antibodies reduced the stimulatory effect of IGF2 and IGF1 on estradiol production and cell proliferation., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0005009 insulin receptor activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0005198 structural molecule activity;GO:0005520 insulin-like growth factor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030424 axon;GO:0005899 insulin receptor complex", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0071333 cellular response to glucose stimulus;GO:0046777 protein autophosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q05688-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05927-1", "uniprot_id": [ { "id": "5NTD_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05927", "type": "external" } ], "mass": 62966.0, "length": 574, "protein_name": "5'-nucleotidase", "gene_name": "NT5E", "organism": "Bovine", "refseq_name": "5'-nucleotidase precursor", "refseq_ac": [ { "id": "NP_776554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776554", "type": "external" } ], "gene_names_uniprotkb": "NT5E; NT5; NTE", "gene_names_refseq": "NT5E", "protein_names_uniprotkb": "5'-nucleotidase; 3.1.3.35; 3.1.3.5; 3.1.3.89; 3.1.3.91; 3.1.3.99; 5'-NT; 5'-deoxynucleotidase; Ecto-5'-nucleotidase; IMP-specific 5'-nucleotidase; Thymidylate 5'-phosphatase", "protein_names_refseq": "5'-NT; 5'-deoxynucleotidase; 5'-nucleotidase precursor; 5'-nucleotidase, ecto (CD73); IMP-specific 5'-nucleotidase; ecto-5'-nucleotidase; thymidylate 5'-phosphatase", "tax_id": 9913, "disease": "", "pathway": " (bta:281363)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10825541;16305752;28504100;31401370;8340354", "class_list": "", "function": "Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate (PubMed:10825541, PubMed:8340354). Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms (By similarity). Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Study concludes that dictyocaulosis alters NTPDase, 5'-nucleotidase, and ADA activities of cow naturally infected by the parasite Dictyocaulus viviparus, in consequence the enzymes act as inflammatory markers, [RefSeq, PubMed]; The degradation rate of Inosine 5'-monophosphate (IMP) in Japanese Black beef was significantly different among NT5E genotypes in the middle stage of postmortem, indicating a significant difference in the concentrations of IMP and its degradation products among NT5E genotypes, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q24K05", "ec_number_list": [ { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.91", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91", "type": "external" }, { "id": "3.1.3.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89", "type": "external" }, { "id": "3.1.3.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99", "type": "external" }, { "id": "3.1.3.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.1.77", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.77", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0008253 5'-nucleotidase activity;GO:0002953 5'-deoxynucleotidase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006196 AMP catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q05927-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q05B92-1", "uniprot_id": [ { "id": "TFE3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q05B92", "type": "external" } ], "mass": 61498.0, "length": 573, "protein_name": "Transcription factor E3", "gene_name": "TFE3", "organism": "Bovine", "refseq_name": "transcription factor E3", "refseq_ac": [ { "id": "NP_001069279", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069279", "type": "external" } ], "gene_names_uniprotkb": "TFE3", "gene_names_refseq": "TFE3", "protein_names_uniprotkb": "Transcription factor E3", "protein_names_refseq": "transcription factor E3", "tax_id": 9913, "disease": "", "pathway": " (bta:520800)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response. Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF. Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its inactivation. Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in transcription factor activity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (By similarity). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent TFE3 cytosolic retention and inactivation promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (By similarity). TFE3 activity is also involved in the inhibition of neuronal progenitor differentiation. Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue. In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer. It also binds very well to a USF/MLTF site. May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045785 positive regulation of cell adhesion;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q05B92-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06154-1", "uniprot_id": [ { "id": "PMEL_BOVIN", "url": "https://www.uniprot.org/uniprot/Q06154", "type": "external" } ], "mass": 69366.0, "length": 649, "protein_name": "Melanocyte protein PMEL", "gene_name": "PMEL", "organism": "Bovine", "refseq_name": "melanocyte protein PMEL precursor", "refseq_ac": [ { "id": "NP_001073684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073684", "type": "external" } ], "gene_names_uniprotkb": "PMEL; PMEL17; RPE1; SILV", "gene_names_refseq": "PMEL17; PMEL; RPE1; SILV", "protein_names_uniprotkb": "Melanocyte protein PMEL; Melanocyte protein Pmel 17; Premelanosome protein; Retinal pigment epithelial-specific protein; Silver locus protein homolog", "protein_names_refseq": "melanocyte protein PMEL precursor; melanocyte protein Pmel 17; pre-melanosomal protein 17; retinal pigment epithelial-specific protein; silver homolog; silver locus protein homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:281487)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "1478275;17705851;17892572;22524257;32668786;36608422", "class_list": "", "function": "Forms physiological amyloids that play a central role in melanosome morphogenesis and pigmentation. The maturation of unpigmented premelanosomes from stage I to II is marked by assembly of processed amyloidogenic fragments into parallel fibrillar sheets, which elongate the vesicle into a striated ellipsoidal shape. In pigmented stage III and IV melanosomes, the amyloid matrix serves as a platform where eumelanin precursors accumulate at high local concentrations for pigment formation. May prevent pigmentation-associated toxicity by sequestering toxic reaction intermediates of eumelanin biosynthesis pathway., [UniProtKB, UniProtKB]; Indication of Premelanosome Protein (PMEL) Expression Outside of Pigmented Bovine Skin Suggests Functions Beyond Eumelanogenesis. Publication Status: Online-Only, [RefSeq, PubMed]; No convincing recombination events were found between the SILV c.64A>G mutation and the Dc locus Publication Status: Online-Only, [RefSeq, PubMed]; Six solid colors occur in Highland cattle: black, dun, silver dun and red, yellow, and white. These six coat colors are explained by a non-epistatic interaction of the genotypes at the MC1R and PMEL genes., [RefSeq, PubMed]; The complex expression pattern of the bovine SILV gene in pigmented and non-pigmented tissues Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "A1YKV3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0005789 endoplasmic reticulum membrane;GO:0042470 melanosome", "go_biological_process": "GO:0032438 melanosome organization;GO:0042438 melanin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q06154-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q06599-1", "uniprot_id": [ { "id": "TNFA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q06599", "type": "external" } ], "mass": 25567.0, "length": 234, "protein_name": "Tumor necrosis factor", "gene_name": "TNF", "organism": "Bovine", "refseq_name": "tumor necrosis factor", "refseq_ac": [ { "id": "NP_776391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776391", "type": "external" } ], "gene_names_uniprotkb": "TNF; TNFA; TNFSF2", "gene_names_refseq": "TNF-alpha; TNF-a; TNFa; TNF", "protein_names_uniprotkb": "Tumor necrosis factor; Cachectin; N-terminal fragment; NTF; TNF-alpha; TNF-a; Tumor necrosis factor ligand superfamily member 2", "protein_names_refseq": "cachectin; tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor", "tax_id": 9913, "disease": "", "pathway": " (bta:280943); (R-BTA-5357786); (R-BTA-5357905); (R-BTA-5357956); (R-BTA-5626978); (R-BTA-5668541); (R-BTA-75893)", "pathway_count": 7, "publication_count": 9, "publication_id_list": "12440939;25589228;25924700;26051703;26618585;33799007;7590981;8260599;9303477", "class_list": "", "function": "Alterations in TNF-alpha and its receptors expression in cows undergoing heat stress., [RefSeq, PubMed]; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data suggest that luteolytic factors (such as TNFa, interferon gamma, and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells., [RefSeq, PubMed]; The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; There was a significant association between the proviral load and a low frequency of the G/G genotype of TNF-alpha at position -824., [RefSeq, PubMed]; These results suggest that polymorphism of the TNFalpha-824 A>G gene and mTNFalpha protein expression play an important role in the pathogenesis of enzootic bovine leukosis., [RefSeq, PubMed]; These results suggest that the endometrium might lower the TNF concentration in the blastocyst by (1) regulating TNF secretion into the uterine fluid and (2) inducing decreased TNF and TNFR2 mRNA transcription in the embryo., [RefSeq, PubMed]; Tumour necrosis factor alpha up-regulates protein kinase R (PKR)-activating protein (PACT) and increases phosphorylation of PKR and eukaryotic initiation factor 2-alpha in articular chondrocytes, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A4IFT5;A9QWR7;O18779;Q27978", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005164 tumor necrosis factor receptor binding;GO:0002020 protease binding;GO:0042802 identical protein binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0001891 phagocytic cup;GO:0045121 membrane raft;GO:0055037 recycling endosome", "go_biological_process": "GO:0010756 positive regulation of plasminogen activation;GO:2000252 negative regulation of feeding behavior;GO:0006955 immune response;GO:0043065 positive regulation of apoptotic process;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q06599-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q07263-1", "uniprot_id": [ { "id": "ACHA3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q07263", "type": "external" } ], "mass": 56914.0, "length": 495, "protein_name": "Neuronal acetylcholine receptor subunit alpha-3", "gene_name": "CHRNA3", "organism": "Bovine", "refseq_name": "neuronal acetylcholine receptor subunit alpha-3 precursor", "refseq_ac": [ { "id": "NP_777144", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777144", "type": "external" } ], "gene_names_uniprotkb": "CHRNA3", "gene_names_refseq": "CHRNA3", "protein_names_uniprotkb": "Neuronal acetylcholine receptor subunit alpha-3", "protein_names_refseq": "cholinergic receptor, nicotinic, alpha 3 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 3; neuronal acetylcholine receptor subunit alpha-3 precursor; neuronal acetylcholine receptor subunit alpha-3", "tax_id": 9913, "disease": "", "pathway": " (bta:282702)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "12438106;12438113;1620271;21420959", "class_list": "", "function": "Bovine chromaffin cells express nicotinic alpha3beta4 acetylcholine receptors, [RefSeq, PubMed]; Bovine chromaffin cells have an alpha3alpha7beta4 nicotinic receptor, [RefSeq, PubMed]; Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (By similarity). CHRNA3 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4 (By similarity). CHRNA3:CHRNB4 being predominant in neurons of the autonomic ganglia, it is known as ganglionic nicotinic receptor (By similarity). CHRNA3:CHRNB4 also plays an important role in the habenulo-interpeduncular tract, modulating the mesolimbic dopamine system and affecting reward circuits and addiction (By similarity). Hypothalamic CHRNA3:CHRNB4 nAChR activation by nicotine leads to activation of POMC neurons and a decrease in food intake (By similarity). Also expressed in the urothelium where it modulates reflex bladder activity by increasing intracellular calcium through extracellular influx and basal ATP release (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data show that a basic residue at position 210 of alpha3 subunit decreases the assembly of heteromeric neuronal alpha3beta4 nicotinic ACh receptors., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015464 acetylcholine receptor activity;GO:0022848 acetylcholine-gated monoatomic cation-selective channel activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005892 acetylcholine-gated channel complex;GO:0045202 synapse", "go_biological_process": "GO:0007165 signal transduction;GO:0007271 synaptic transmission, cholinergic;GO:0007274 neuromuscular synaptic transmission;GO:0007399 nervous system development;GO:0035094 response to nicotine", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q07263-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08537-1", "uniprot_id": [ { "id": "UPK2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08537", "type": "external" } ], "mass": 19619.0, "length": 185, "protein_name": "Uroplakin-2", "gene_name": "UPK2", "organism": "Bovine", "refseq_name": "uroplakin-2 precursor", "refseq_ac": [ { "id": "NP_776639", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776639", "type": "external" } ], "gene_names_uniprotkb": "UPK2", "gene_names_refseq": "UPK2", "protein_names_uniprotkb": "Uroplakin-2; UP2; UPII; Uroplakin II", "protein_names_refseq": "UP2; UPII; uroplakin II; uroplakin-2 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281569)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "12475947;7507484", "class_list": "", "function": "Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0120001 apical plasma membrane urothelial plaque;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030855 epithelial cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q08537-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DF2-1", "uniprot_id": [ { "id": "RN112_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DF2", "type": "external" } ], "mass": 67392.0, "length": 628, "protein_name": "RING finger protein 112", "gene_name": "RNF112", "organism": "Bovine", "refseq_name": "RING finger protein 112", "refseq_ac": [ { "id": "NP_001070607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070607", "type": "external" } ], "gene_names_uniprotkb": "RNF112; ZNF179", "gene_names_refseq": "RNF112; ZNF179", "protein_names_uniprotkb": "RING finger protein 112; 2.3.2.27; Zinc finger protein 179", "protein_names_refseq": "RING finger protein 112; zinc finger protein 179", "tax_id": 9913, "disease": "", "pathway": " (bta:768085)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins. Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage. Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0014069 postsynaptic density", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0030182 neuron differentiation;GO:0051865 protein autoubiquitination;GO:1990403 embryonic brain development;GO:0033194 response to hydroperoxide", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DF2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DF7-1", "uniprot_id": [ { "id": "PDE12_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DF7", "type": "external" } ], "mass": 67264.0, "length": 609, "protein_name": "2',5'-phosphodiesterase 12", "gene_name": "PDE12", "organism": "Bovine", "refseq_name": "2',5'-phosphodiesterase 12", "refseq_ac": [ { "id": "NP_001069601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069601", "type": "external" } ], "gene_names_uniprotkb": "PDE12", "gene_names_refseq": "2'-PDE; PDE12", "protein_names_uniprotkb": "2',5'-phosphodiesterase 12; 2'-PDE; 2-PDE; 3.1.13.4; 3.1.4.-; Mitochondrial deadenylase", "protein_names_refseq": "2',5'-phosphodiesterase 12; 2'-phosphodiesterase; 2-PDE; mitochondrial deadenylase", "tax_id": 9913, "disease": "", "pathway": " (bta:538860); (R-BTA-8983711)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15231837", "class_list": "", "function": "Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0004535 poly(A)-specific ribonuclease activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0071359 cellular response to dsRNA;GO:0006397 mRNA processing;GO:0071346 cellular response to type II interferon;GO:0045070 positive regulation of viral genome replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08DF7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DS3-1", "uniprot_id": [ { "id": "OSR1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DS3", "type": "external" } ], "mass": 29626.0, "length": 267, "protein_name": "Protein odd-skipped-related 1", "gene_name": "OSR1", "organism": "Bovine", "refseq_name": "protein odd-skipped-related 1", "refseq_ac": [ { "id": "NP_001070384", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070384", "type": "external" } ], "gene_names_uniprotkb": "OSR1; ODD1", "gene_names_refseq": "OSR1", "protein_names_uniprotkb": "Protein odd-skipped-related 1", "protein_names_refseq": "odd-skipped related transciption factor 1; protein odd-skipped-related 1", "tax_id": 9913, "disease": "", "pathway": " (bta:539430)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that plays a role in the regulation of embryonic heart and urogenital development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0072180 mesonephric duct morphogenesis;GO:0072111 cell proliferation involved in kidney development;GO:0072143 mesangial cell development;GO:0072162 metanephric mesenchymal cell differentiation;GO:0072168 specification of anterior mesonephric tubule identity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DS3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DV0-1", "uniprot_id": [ { "id": "GATA3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DV0", "type": "external" } ], "mass": 47807.0, "length": 443, "protein_name": "Trans-acting T-cell-specific transcription factor GATA-3", "gene_name": "GATA3", "organism": "Bovine", "refseq_name": "trans-acting T-cell-specific transcription factor GATA-3", "refseq_ac": [ { "id": "NP_001070272", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070272", "type": "external" } ], "gene_names_uniprotkb": "GATA3", "gene_names_refseq": "GATA3", "protein_names_uniprotkb": "Trans-acting T-cell-specific transcription factor GATA-3; GATA-binding factor 3", "protein_names_refseq": "GATA-binding factor 3; trans-acting T-cell-specific transcription factor GATA-3", "tax_id": 9913, "disease": "", "pathway": " (bta:505169); (R-BTA-5689880); (R-BTA-8939236); (R-BTA-9018519); (R-BTA-983231)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "21606631", "class_list": "", "function": "GATA2 and/or GATA3 are involved in the regulation of trophoblast-specific gene transcription in bovine trophoblast CT-1 cells, [RefSeq, PubMed]; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses (By similarity). Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0005654 nucleoplasm", "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08DV0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08DW9-1", "uniprot_id": [ { "id": "ABD12_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08DW9", "type": "external" } ], "mass": 45220.0, "length": 398, "protein_name": "Lysophosphatidylserine lipase ABHD12", "gene_name": "ABHD12", "organism": "Bovine", "refseq_name": "lysophosphatidylserine lipase ABHD12", "refseq_ac": [ { "id": "NP_001071584", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071584", "type": "external" } ], "gene_names_uniprotkb": "ABHD12", "gene_names_refseq": "ABHD12", "protein_names_uniprotkb": "Lysophosphatidylserine lipase ABHD12; 2-arachidonoylglycerol hydrolase ABHD12; 3.1.-.-; 3.1.1.-; 3.1.1.23; Abhydrolase domain-containing protein 12; Monoacylglycerol lipase ABHD12; Oxidized phosphatidylserine lipase ABHD12", "protein_names_refseq": "2-arachidonoylglycerol hydrolase ABHD12; abhydrolase domain-containing protein 12; lysophosphatidylserine lipase ABHD12; monoacylglycerol lipase ABHD12; oxidized phosphatidylserine lipase ABHD12", "tax_id": 9913, "disease": "", "pathway": " (bta:768242); (R-BTA-426048)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.38", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.2.2.19", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.19", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0047372 monoacylglycerol lipase activity;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0120560 phosphatidylserine lysophospholipase activity;GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032281 AMPA glutamate receptor complex;GO:0032839 dendrite cytoplasm", "go_biological_process": "GO:0009395 phospholipid catabolic process;GO:0046464 acylglycerol catabolic process;GO:0052651 monoacylglycerol catabolic process;GO:0006660 phosphatidylserine catabolic process;GO:0050727 regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q08DW9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q08E52-1", "uniprot_id": [ { "id": "PAK1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q08E52", "type": "external" } ], "mass": 60546.0, "length": 544, "protein_name": "Serine/threonine-protein kinase PAK 1", "gene_name": "PAK1", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase PAK 1", "refseq_ac": [ { "id": "NP_001070366", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070366", "type": "external" } ], "gene_names_uniprotkb": "PAK1", "gene_names_refseq": "PAK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase PAK 1; 2.7.11.1; Alpha-PAK; PAK-1; p21-activated kinase 1; p65-PAK", "protein_names_refseq": "PAK-1; alpha-PAK; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p65-PAK; serine/threonine-protein kinase PAK 1", "tax_id": 9913, "disease": "", "pathway": " (bta:533729); (R-BTA-202433); (R-BTA-2029482); (R-BTA-2871796); (R-BTA-389359); (R-BTA-3928664); (R-BTA-399954); (R-BTA-445355); (R-BTA-5218920); (R-BTA-5627123); (R-BTA-5687128); (R-BTA-8964616); (R-BTA-9013404); (R-BTA-9013406); (R-BTA-9013407); (R-BTA-9013420); (R-BTA-9013423); (R-BTA-9013424)", "pathway_count": 18, "publication_count": 1, "publication_id_list": "21457715", "class_list": "", "function": "Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (By similarity). Can directly phosphorylate BAD and protects cells against apoptosis (By similarity). Activated by interaction with CDC42 and RAC1 (By similarity). Functions as a GTPase effector that links the Rho-related GTPases CDC42 and RAC1 to the JNK MAP kinase pathway (By similarity). Phosphorylates and activates MAP2K1, and thereby mediates activation of downstream MAP kinases (By similarity). Involved in the reorganization of the actin cytoskeleton, actin stress fibers and of focal adhesion complexes (By similarity). Phosphorylates the tubulin chaperone TBCB and thereby plays a role in the regulation of microtubule biogenesis and organization of the tubulin cytoskeleton (By similarity). Plays a role in the regulation of insulin secretion in response to elevated glucose levels (By similarity). Part of a ternary complex that contains PAK1, DVL1 and MUSK that is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ) (By similarity). Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2 (By similarity). Phosphorylates MYL9/MLC2 (PubMed:21457715). Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2 (By similarity). Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus (By similarity). In podocytes, promotes NR3C2 nuclear localization (By similarity). Required for atypical chemokine receptor ACKR2-induced phosphorylation of LIMK1 and cofilin (CFL1) and for the up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). In synapses, seems to mediate the regulation of F-actin cluster formation performed by SHANK3, maybe through CFL1 phosphorylation and inactivation (By similarity). Plays a role in RUFY3-mediated facilitating gastric cancer cells migration and invasion (By similarity). In response to DNA damage, phosphorylates MORC2 which activates its ATPase activity and facilitates chromatin remodeling (By similarity). In neurons, plays a crucial role in regulating GABA(A) receptor synaptic stability and hence GABAergic inhibitory synaptic transmission through its role in F-actin stabilization (By similarity). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). Along with GIT1, positively regulates microtubule nucleation during interphase (By similarity). Phosphorylates FXR1, promoting its localization to stress granules and activity (By similarity). Phosphorylates ILK on 'Thr-173' and 'Ser-246', promoting nuclear export of ILK (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 22, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.18", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0005518 collagen binding;GO:0043015 gamma-tubulin binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005911 cell-cell junction", "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0060244 negative regulation of cell proliferation involved in contact inhibition;GO:1903608 protein localization to cytoplasmic stress granule;GO:0006338 chromatin remodeling;GO:0016477 cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q08E52-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q09430-1", "uniprot_id": [ { "id": "PROF2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q09430", "type": "external" } ], "mass": 15032.0, "length": 140, "protein_name": "Profilin-2", "gene_name": "PFN2", "organism": "Bovine", "refseq_name": "profilin-2", "refseq_ac": [ { "id": "NP_001121669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121669", "type": "external" } ], "gene_names_uniprotkb": "PFN2", "gene_names_refseq": "PFN2", "protein_names_uniprotkb": "Profilin-2; Profilin II", "protein_names_refseq": "profilin II; profilin-2", "tax_id": 9913, "disease": "", "pathway": " (bta:539034); (R-BTA-5663220)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7601111", "class_list": "", "function": "Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A4FUW7", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton", "go_biological_process": "GO:0032233 positive regulation of actin filament bundle assembly;GO:0030036 actin cytoskeleton organization;GO:0030833 regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q09430-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0IIM2-1", "uniprot_id": [ { "id": "ARL6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0IIM2", "type": "external" } ], "mass": 21055.0, "length": 186, "protein_name": "ADP-ribosylation factor-like protein 6", "gene_name": "ARL6", "organism": "Bovine", "refseq_name": "ADP-ribosylation factor-like protein 6", "refseq_ac": [ { "id": "NP_001069250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069250", "type": "external" } ], "gene_names_uniprotkb": "ARL6", "gene_names_refseq": "ARL6", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 6", "protein_names_refseq": "ADP-ribosylation factor-like 6; ADP-ribosylation factor-like protein 6", "tax_id": 9913, "disease": "", "pathway": " (bta:519014); (R-BTA-5620922)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "20603001", "class_list": "", "function": "Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005543 phospholipid binding;GO:0062063 BBSome binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005930 axoneme;GO:0060170 ciliary membrane;GO:0030117 membrane coat", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006612 protein targeting to membrane;GO:0060271 cilium assembly;GO:0016055 Wnt signaling pathway;GO:0045444 fat cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0IIM2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0P5G4-1", "uniprot_id": [ { "id": "KAT3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0P5G4", "type": "external" } ], "mass": 51472.0, "length": 455, "protein_name": "Kynurenine--oxoglutarate transaminase 3", "gene_name": "KYAT3", "organism": "Bovine", "refseq_name": "kynurenine--oxoglutarate transaminase 3", "refseq_ac": [ { "id": "NP_001068838", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068838", "type": "external" } ], "gene_names_uniprotkb": "KYAT3; CCBL2; KAT3", "gene_names_refseq": "CCBL2; KYAT3", "protein_names_uniprotkb": "Kynurenine--oxoglutarate transaminase 3; 2.6.1.63; 2.6.1.7; 4.4.1.13; Cysteine-S-conjugate beta-lyase 2; KATIII; Kynurenine aminotransferase 3; Kynurenine aminotransferase III; Kynurenine--glyoxylate transaminase; Kynurenine--oxoglutarate transaminase III", "protein_names_refseq": "KATIII; cysteine conjugate-beta lyase 2; cysteine-S-conjugate beta-lyase 2; kynurenine aminotransferase III; kynurenine--glyoxylate transaminase; kynurenine--oxoglutarate transaminase 3; kynurenine--oxoglutarate transaminase III", "tax_id": 9913, "disease": "", "pathway": " (bta:508712)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.63", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.63", "type": "external" }, { "id": "2.6.1.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.39", "type": "external" }, { "id": "2.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.7", "type": "external" }, { "id": "2.6.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.4", "type": "external" }, { "id": "2.6.1.73", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.73", "type": "external" }, { "id": "2.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.64", "type": "external" }, { "id": "4.4.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.13", "type": "external" } ], "go_molecular_function": "GO:0047315 kynurenine-glyoxylate transaminase activity;GO:0016212 kynurenine-oxoglutarate transaminase activity;GO:0030170 pyridoxal phosphate binding;GO:0047804 cysteine-S-conjugate beta-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0097053 L-kynurenine catabolic process;GO:0070189 kynurenine metabolic process;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0P5G4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V7M1-1", "uniprot_id": [ { "id": "KPSH1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V7M1", "type": "external" } ], "mass": 48009.0, "length": 424, "protein_name": "Serine/threonine-protein kinase H1", "gene_name": "PSKH1", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase H1", "refseq_ac": [ { "id": "NP_001068881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068881", "type": "external" } ], "gene_names_uniprotkb": "PSKH1", "gene_names_refseq": "PSKH1", "protein_names_uniprotkb": "Serine/threonine-protein kinase H1; 2.7.11.1; PSK-H1; Protein serine kinase H1", "protein_names_refseq": "PSK-H1; serine/threonine-protein kinase H1", "tax_id": 9913, "disease": "", "pathway": " (bta:509656)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V7M1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8B6-1", "uniprot_id": [ { "id": "TPP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8B6", "type": "external" } ], "mass": 61352.0, "length": 563, "protein_name": "Tripeptidyl-peptidase 1", "gene_name": "TPP1", "organism": "Bovine", "refseq_name": "tripeptidyl-peptidase 1 precursor", "refseq_ac": [ { "id": "NP_001069186", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069186", "type": "external" } ], "gene_names_uniprotkb": "TPP1; CLN2", "gene_names_refseq": "CLN2; TPP-1; TPP-I; TPP1", "protein_names_uniprotkb": "Tripeptidyl-peptidase 1; 3.4.14.9; TPP-1; TPP-I; Tripeptidyl aminopeptidase; Tripeptidyl-peptidase I", "protein_names_refseq": "tripeptidyl aminopeptidase; tripeptidyl-peptidase 1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:515575)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0046872 metal ion binding;GO:0008240 tripeptidyl-peptidase activity;GO:0035727 lysophosphatidic acid binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0045121 membrane raft;GO:0055037 recycling endosome;GO:0005764 lysosome;GO:0042470 melanosome", "go_biological_process": "GO:0006508 proteolysis;GO:0007399 nervous system development;GO:0043171 peptide catabolic process;GO:0007417 central nervous system development;GO:0045453 bone resorption", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8B6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0V8H6-1", "uniprot_id": [ { "id": "MOV10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0V8H6", "type": "external" } ], "mass": 113885.0, "length": 1003, "protein_name": "RNA helicase MOV-10", "gene_name": "MOV10", "organism": "Bovine", "refseq_name": "putative helicase MOV-10", "refseq_ac": [ { "id": "NP_001069307", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069307", "type": "external" } ], "gene_names_uniprotkb": "MOV10", "gene_names_refseq": "MOV10", "protein_names_uniprotkb": "RNA helicase MOV-10; 5.6.2.5; RNA 5'-3' helicase MOV-10", "protein_names_refseq": "Mov10, Moloney leukemia virus 10, homolog; putative helicase MOV-10", "tax_id": 9913, "disease": "", "pathway": " (bta:523206)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "5'-3' RNA helicase that is involved in a number of cellular roles ranging from mRNA metabolism and translation, modulation of viral infectivity, inhibition of retrotransposition, or regulation of synaptic transmission. Plays an important role in innate antiviral immunity by promoting type I interferon production. Mechanistically, specifically uses IKKepsilon/IKBKE as the mediator kinase for IRF3 activation. Contributes to UPF1 mRNA target degradation by translocation along 3' UTRs. Required for microRNA (miRNA)-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. In cooperation with FMR1, regulates miRNA-mediated translational repression by AGO2. Restricts retrotransposition of long interspersed element-1 (LINE-1) in cooperation with TUT4 and TUT7 counteracting the RNA chaperonne activity of L1RE1. Facilitates LINE-1 uridylation by TUT4 and TUT7 (By similarity). Required for embryonic viability and for normal central nervous system development and function. Plays two critical roles in early brain development: suppresses retroelements in the nucleus by directly inhibiting cDNA synthesis, while regulates cytoskeletal mRNAs to influence neurite outgrowth in the cytosol (By similarity). May function as a messenger ribonucleoprotein (mRNP) clearance factor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0032574 5'-3' RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0036464 cytoplasmic ribonucleoprotein granule;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:0035279 miRNA-mediated gene silencing by mRNA destabilization;GO:0035195 miRNA-mediated post-transcriptional gene silencing;GO:0061014 positive regulation of mRNA catabolic process;GO:0061158 3'-UTR-mediated mRNA destabilization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0V8H6-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC00-1", "uniprot_id": [ { "id": "ABHD3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC00", "type": "external" } ], "mass": 46527.0, "length": 411, "protein_name": "Phospholipase ABHD3", "gene_name": "ABHD3", "organism": "Bovine", "refseq_name": "phospholipase ABHD3", "refseq_ac": [ { "id": "NP_001069655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069655", "type": "external" } ], "gene_names_uniprotkb": "ABHD3", "gene_names_refseq": "ABHD3", "protein_names_uniprotkb": "Phospholipase ABHD3; 3.1.1.32; 3.1.1.4; Abhydrolase domain-containing protein 3", "protein_names_refseq": "abhydrolase domain-containing protein 3; phospholipase ABHD3", "tax_id": 9913, "disease": "", "pathway": " (bta:539795); (R-BTA-1483191)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phospholipase that may play a role in phospholipids remodeling. May selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position. In parallel, may have a minor phospholipase 2 activity acting on acyl groups in position sn2. In addition to (C14)-containing phosphatidylcholines, may also act on other medium-chain-containing and oxidatively truncated phospholipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.111", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111", "type": "external" }, { "id": "3.1.1.118", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0047372 monoacylglycerol lipase activity;GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0008126 acetylesterase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0046470 phosphatidylcholine metabolic process;GO:0051793 medium-chain fatty acid catabolic process;GO:0051792 medium-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC00-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC36-1", "uniprot_id": [ { "id": "1433S_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC36", "type": "external" } ], "mass": 27849.0, "length": 248, "protein_name": "14-3-3 protein sigma", "gene_name": "SFN", "organism": "Bovine", "refseq_name": "14-3-3 protein sigma", "refseq_ac": [ { "id": "NP_001069380", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069380", "type": "external" } ], "gene_names_uniprotkb": "SFN", "gene_names_refseq": "SFN", "protein_names_uniprotkb": "14-3-3 protein sigma; Stratifin", "protein_names_refseq": "14-3-3 protein sigma; epithelial cell marker protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:528453); (R-BTA-111447); (R-BTA-5625740); (R-BTA-5628897); (R-BTA-6804114); (R-BTA-75035); (R-BTA-9614399); (R-BTA-9968551)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response. Also acts as a TP53/p53-regulated inhibitor of G2/M progression (By similarity). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (By similarity). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (By similarity). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0050815 phosphoserine residue binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0030307 positive regulation of cell growth;GO:0045785 positive regulation of cell adhesion;GO:0061436 establishment of skin barrier;GO:0046827 positive regulation of protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC36-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VC44-1", "uniprot_id": [ { "id": "SPXN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VC44", "type": "external" } ], "mass": 13390.0, "length": 116, "protein_name": "Spexin", "gene_name": "SPX", "organism": "Bovine", "refseq_name": "spexin precursor", "refseq_ac": [ { "id": "NP_001068875", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068875", "type": "external" } ], "gene_names_uniprotkb": "SPX", "gene_names_refseq": "C5H12orf39; NPQ; SPX", "protein_names_uniprotkb": "Spexin; NPQ 53-70; NPQ; Neuropeptide Q; Spexin hormone", "protein_names_refseq": "neuropeptide Q; spexin precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:509493)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a ligand for galanin receptors GALR2 and GALR3. Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity)., [UniProtKB]; Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity)., [UniProtKB]; Plays a role as a central modulator of cardiovascular and renal function and nociception. Also plays a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005184 neuropeptide hormone activity;GO:0031765 type 2 galanin receptor binding;GO:0031766 type 3 galanin receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0030133 transport vesicle;GO:0031045 dense core granule", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0003084 positive regulation of systemic arterial blood pressure;GO:0035814 negative regulation of renal sodium excretion;GO:0051930 regulation of sensory perception of pain;GO:0044539 long-chain fatty acid import into cell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VC44-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCA3-1", "uniprot_id": [ { "id": "LETM1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCA3", "type": "external" } ], "mass": 81818.0, "length": 732, "protein_name": "Mitochondrial proton/calcium exchanger protein", "gene_name": "LETM1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LETM1", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial proton/calcium exchanger protein; Electroneutral mitochondrial K(+)/H(+)exchanger; KHE; Leucine zipper-EF-hand-containing transmembrane protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:513324)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "28100784", "class_list": "", "function": "Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (By similarity). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Also functions as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain (By similarity). Required for the maintenance of the tubular shape and cristae organization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0043022 ribosome binding;GO:0015369 calcium:proton antiporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0051562 negative regulation of mitochondrial calcium ion concentration;GO:0051260 protein homooligomerization;GO:0007005 mitochondrion organization;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0051560 mitochondrial calcium ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q0VCA3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCB2-1", "uniprot_id": [ { "id": "HDAC8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCB2", "type": "external" } ], "mass": 41683.0, "length": 377, "protein_name": "Histone deacetylase 8", "gene_name": "HDAC8", "organism": "Bovine", "refseq_name": "histone deacetylase 8", "refseq_ac": [ { "id": "NP_001069699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069699", "type": "external" } ], "gene_names_uniprotkb": "HDAC8", "gene_names_refseq": "HDAC8", "protein_names_uniprotkb": "Histone deacetylase 8; 3.5.1.-; 3.5.1.98; HD8; Protein deacetylase HDAC8; Protein decrotonylase HDAC8", "protein_names_refseq": "HD8; histone deacetylase 8; protein deacetylase HDAC8; protein decrotonylase HDAC8", "tax_id": 9913, "disease": "", "pathway": " (bta:540666)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.98", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004407 histone deacetylase activity;GO:0160009 histone decrotonylase activity;GO:0141221 histone deacetylase activity, hydrolytic mechanism", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005694 chromosome;GO:0000118 histone deacetylase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007064 mitotic sister chromatid cohesion;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCB2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCM6-1", "uniprot_id": [ { "id": "LAT4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCM6", "type": "external" } ], "mass": 62656.0, "length": 568, "protein_name": "Large neutral amino acids transporter small subunit 4", "gene_name": "SLC43A2", "organism": "Bovine", "refseq_name": "large neutral amino acids transporter small subunit 4", "refseq_ac": [ { "id": "NP_001069014", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069014", "type": "external" } ], "gene_names_uniprotkb": "SLC43A2; LAT4", "gene_names_refseq": "SLC43A2", "protein_names_uniprotkb": "Large neutral amino acids transporter small subunit 4; L-type amino acid transporter 4; Solute carrier family 43 member 2", "protein_names_refseq": "L-type amino acid transporter 4; large neutral amino acids transporter small subunit 4", "tax_id": 9913, "disease": "", "pathway": " (bta:511955); (R-BTA-352230)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "30573663", "class_list": "", "function": "Uniporter that mediates the transport of the stereospecific L-phenylalanine, L-methionine and L-branched-chain amino acids, between the extracellular space and the cytoplasm and may control the transepithelial (re)absorption of neutral amino acid in kidney and small intestine. The transport activity is mediated through facilitated diffusion and is sodium ions-, chloride ions- and pH-independent. Mediates the efflux of 3,3'-diiodo-L-thyronine (3,3'-T2) and 3-iodo-L-tyrosine (MIT)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015188 L-isoleucine transmembrane transporter activity;GO:0015179 L-amino acid transmembrane transporter activity;GO:0015175 neutral L-amino acid transmembrane transporter activity;GO:0015190 L-leucine transmembrane transporter activity;GO:0015191 L-methionine transmembrane transporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0015820 L-leucine transport;GO:0015804 neutral amino acid transport;GO:0015823 phenylalanine transport;GO:0015818 isoleucine transport;GO:0015821 methionine transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VCM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCP1-1", "uniprot_id": [ { "id": "KAD4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCP1", "type": "external" } ], "mass": 25348.0, "length": 223, "protein_name": "Adenylate kinase 4, mitochondrial", "gene_name": "AK4", "organism": "Bovine", "refseq_name": "adenylate kinase 4, mitochondrial", "refseq_ac": [ { "id": "NP_001071401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071401", "type": "external" } ], "gene_names_uniprotkb": "AK4", "gene_names_refseq": "AK 4; AK3L1; AK4", "protein_names_uniprotkb": "Adenylate kinase 4, mitochondrial; 2.7.4.4; 2.7.4.6; Adenylate kinase 3-like; GTP:AMP phosphotransferase AK4", "protein_names_refseq": "ATP-AMP transphosphorylase; GTP:AMP phosphotransferase AK4, mitochondrial; adenylate kinase 3-like 1; adenylate kinase 4, mitochondrial; adenylate kinase isoenzyme 4, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:517063); (R-BTA-499943)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Broad-specificity mitochondrial nucleoside phosphate kinase involved in cellular nucleotide homeostasis by catalyzing nucleoside-phosphate interconversions. Similar to other adenylate kinases, preferentially catalyzes the phosphorylation of the nucleoside monophosphate AMP with ATP as phosphate donor to produce ADP. Phosphorylates only AMP when using GTP as phosphate donor. In vitro, can also catalyze the phosphorylation of CMP, dAMP and dCMP and use GTP as an alternate phosphate donor. Moreover, exhibits a diphosphate kinase activity, producing ATP, CTP, GTP, UTP, TTP, dATP, dCTP and dGTP from the corresponding diphosphate substrates with either ATP or GTP as phosphate donors. Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK. Plays a protective role in the cellular response to oxidative stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0046899 nucleoside triphosphate adenylate kinase activity;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006172 ADP biosynthetic process;GO:0046033 AMP metabolic process;GO:0071456 cellular response to hypoxia;GO:0046034 ATP metabolic process;GO:0046039 GTP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCP1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCU1-1", "uniprot_id": [ { "id": "ACOHC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCU1", "type": "external" } ], "mass": 98204.0, "length": 889, "protein_name": "Cytoplasmic aconitate hydratase", "gene_name": "ACO1", "organism": "Bovine", "refseq_name": "cytoplasmic aconitate hydratase", "refseq_ac": [ { "id": "NP_001069059", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069059", "type": "external" } ], "gene_names_uniprotkb": "ACO1", "gene_names_refseq": "ACO1", "protein_names_uniprotkb": "Cytoplasmic aconitate hydratase; 4.2.1.3; Aconitase; Citrate hydro-lyase; IRE-BP 1; Iron-responsive element-binding protein 1", "protein_names_refseq": "IRE-BP 1; aconitase 1, soluble; citrate hydro-lyase; cytoplasmic aconitate hydratase; iron-responsive element-binding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:512995)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1281544", "class_list": "", "function": "Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA., [UniProtKB, PubMed]; Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" } ], "go_molecular_function": "GO:0003994 aconitate hydratase activity;GO:0051538 3 iron, 4 sulfur cluster binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0030350 iron-responsive element binding;GO:0008198 ferrous iron binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006101 citrate metabolic process;GO:0006879 intracellular iron ion homeostasis;GO:0010040 response to iron(II) ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VCU1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCX2-1", "uniprot_id": [ { "id": "BIP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCX2", "type": "external" } ], "mass": 72400.0, "length": 655, "protein_name": "Endoplasmic reticulum chaperone BiP", "gene_name": "HSPA5", "organism": "Bovine", "refseq_name": "endoplasmic reticulum chaperone BiP precursor", "refseq_ac": [ { "id": "NP_001068616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068616", "type": "external" } ], "gene_names_uniprotkb": "HSPA5; GRP78", "gene_names_refseq": "BiP; HSPA5; grp78", "protein_names_uniprotkb": "Endoplasmic reticulum chaperone BiP; 3.6.4.10; 78 kDa glucose-regulated protein; BiP; Binding-immunoglobulin protein; GRP-78; HSP70 family protein 5; Heat shock protein 70 family protein 5; Heat shock protein family A member 5; Immunoglobulin heavy chain-binding protein", "protein_names_refseq": "78 kDa glucose-regulated protein; GRP-78; HSP70 family protein 5; binding-immunoglobulin protein; endoplasmic reticulum chaperone BiP precursor; endoplasmic reticulum chaperone BiP; heat shock 70 kDa protein 5; heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa); heat shock protein 70 family protein 5; heat shock protein family A member 5; immunoglobulin heavy chain-binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:415113); (R-BTA-3371453); (R-BTA-983170); (R-BTA-9909505)", "pathway_count": 4, "publication_count": 5, "publication_id_list": "15286042;16305752;17024087;31660059;41018975", "class_list": "", "function": "BiP is a master regulator of endoplasmic reticulum function, and its cleavage by subtilase cytotoxin represents a previously unknown trigger for cell death, [RefSeq, PubMed]; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the EIF2AK3/PERK and ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1. Also binds and inactivates EIF2AK3/PERK in unstressed cells. Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1 and EIF2AK3/PERK, allowing their homodimerization and subsequent activation (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins across endoplasmic reticulum (ER). May function as an allosteric modulator for SEC61 channel-forming translocon complex, likely cooperating with SEC62 to enable the productive insertion of these precursors into SEC61 channel. Appears to specifically regulate translocation of precursors having inhibitory residues in their mature region that weaken channel gating. May also play a role in apoptosis and cell proliferation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; These data reveal that GRP78 is an important regulator of milk biosynthesis and the proliferation of bovine mammary epithelial cells through the mTOR signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; This paper reports the localization of both GRP78 and HSP60 on the luminal/apical surface of oviduct epithelial cells, their binding to spermatozoa, and the presence of endogenous HSP60 in the sperm midpiece., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7E3V5", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0036498 IRE1-mediated unfolded protein response;GO:0043066 negative regulation of apoptotic process;GO:0031398 positive regulation of protein ubiquitination;GO:0042149 cellular response to glucose starvation", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q0VCX2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCX4-1", "uniprot_id": [ { "id": "CTNB1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCX4", "type": "external" } ], "mass": 85511.0, "length": 781, "protein_name": "Catenin beta-1", "gene_name": "CTNNB1", "organism": "Bovine", "refseq_name": "catenin beta-1", "refseq_ac": [ { "id": "NP_001069609", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069609", "type": "external" } ], "gene_names_uniprotkb": "CTNNB1", "gene_names_refseq": "CTNNB1", "protein_names_uniprotkb": "Catenin beta-1; Beta-catenin", "protein_names_refseq": "beta-catenin; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta-1", "tax_id": 9913, "disease": "", "pathway": " (bta:539003); (R-BTA-195253); (R-BTA-196299); (R-BTA-201681); (R-BTA-201722); (R-BTA-3134973); (R-BTA-351906); (R-BTA-3769402); (R-BTA-4086398); (R-BTA-418990); (R-BTA-4641262); (R-BTA-5218920); (R-BTA-525793); (R-BTA-5626467); (R-BTA-8951430); (R-BTA-9762292); (R-BTA-9764561); (R-BTA-9766229); (R-BTA-9768727); (R-BTA-9825892); (R-BTA-9943962); (R-BTA-9958810); (R-BTA-9958825)", "pathway_count": 23, "publication_count": 11, "publication_id_list": "10873669;16305752;16956737;17673669;20427566;21402455;22696613;26515369;26739046;27788397;29668981", "class_list": "", "function": "Beta-catenin, a transcription factor activated by the canonical Wnt signaling pathway, was frequently detected in bovine herpesvirus 1 ORF2-positive trigeminal ganglionic neurons of latently infected, but not mock-infected, calves. Publication Status: Online-Only, [RefSeq, PubMed]; Bovine herpesvirus 1 transiently increased beta-catenin protein levels in bovine kidney cells, but not in rabbit skin cells., [RefSeq, PubMed]; Key downstream component of the canonical Wnt signaling pathway (By similarity). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes (By similarity). Also acts as a coactivator for other transcription factors, such as NR5A2 (By similarity). Promotes epithelial to mesenchymal transition/mesenchymal to epithelial transition (EMT/MET) via driving transcription of CTNNB1/TCF-target genes (By similarity). Involved in the regulation of cell adhesion, as component of an E-cadherin:catenin adhesion complex (By similarity). Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (By similarity). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle. Involved in chondrocyte differentiation via interaction with SOX9: SOX9-binding competes with the binding sites of TCF/LEF within CTNNB1, thereby inhibiting the Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, via promoting the transcription of differentiation factors such as LEF1, BMP2 and BMP4 (By similarity). Activity is repressed in a MSX1-mediated manner at the bell stage of mesenchymal tooth germ formation which prevents premature differentiation of odontoblasts (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; TGF-beta3 induces the chondrogenic differentiation of pericytes by inducing Wnt/beta-catenin signaling and T-cell factor-induced gene transcription., [RefSeq, PubMed]; These data demonstrate for the first time that FSH regulates CTNNB1 protein and WNT2 mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT signaling in ovarian steroidogenesis and follicular growth of cattle., [RefSeq, PubMed]; These data provide evidence that testosterone increases cellular beta-catenin content which promotes the expression of beta-catenin-targeted genes and myogenesis in the muscle-derived stem cells of cattle., [RefSeq, PubMed]; These results demonstrate that activation of AKT is required for gonadotropin regulation of CTNNB1 accumulation and subsequent ovarian E2 production., [RefSeq, PubMed]; This study demonstrated a relationship between the timing of the development of in vitro-produced bovine embryos and the distribution and localization of the junction protein beta-catenin., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A7E3R2", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0045296 cadherin binding;GO:0019903 protein phosphatase binding;GO:0045294 alpha-catenin binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition;GO:0090279 regulation of calcium ion import;GO:0030997 regulation of centriole-centriole cohesion;GO:0006351 DNA-templated transcription;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 1.2, "record_id": "Q0VCX4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VCZ3-1", "uniprot_id": [ { "id": "YTHD2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VCZ3", "type": "external" } ], "mass": 62449.0, "length": 580, "protein_name": "YTH domain-containing family protein 2", "gene_name": "YTHDF2", "organism": "Bovine", "refseq_name": "YTH domain-containing family protein 2", "refseq_ac": [ { "id": "NP_001069721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069721", "type": "external" } ], "gene_names_uniprotkb": "YTHDF2", "gene_names_refseq": "YTHDF2", "protein_names_uniprotkb": "YTH domain-containing family protein 2", "protein_names_refseq": "YTH N6-methyladenosine RNA binding protein 2; YTH domain family protein 2; YTH domain family, member 2; YTH domain-containing family protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:541050)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context. The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation. M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex. Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs (By similarity). Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development. Also required during spermatogenesis: regulates spermagonial adhesion by promoting degradation of m6A-containing transcripts coding for matrix metallopeptidases (By similarity). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation (By similarity). Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets (By similarity). Inhibits neural specification of induced pluripotent stem cells by binding to methylated neural-specific mRNAs and promoting their degradation, thereby restraining neural differentiation. Regulates circadian regulation of hepatic lipid metabolism: acts by promoting m6A-dependent degradation of PPARA transcripts. Regulates the innate immune response to infection by inhibiting the type I interferon response: acts by binding to m6A-containing IFNB transcripts and promoting their degradation. May also act as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation. Regulates mitotic entry by promoting the phase-specific m6A-dependent degradation of WEE1 transcripts. Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation. The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules. May also recognize and bind RNAs modified by C5-methylcytosine (m5C) and act as a regulator of rRNA processing (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:1990247 N6-methyladenosine-containing RNA reader activity;GO:0062153 C5-methylcytidine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000932 P-body;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:1903679 positive regulation of cap-independent translational initiation;GO:2000232 regulation of rRNA processing;GO:0030155 regulation of cell adhesion;GO:0045087 innate immune response;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VCZ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VD19-1", "uniprot_id": [ { "id": "ASM_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VD19", "type": "external" } ], "mass": 69392.0, "length": 625, "protein_name": "Sphingomyelin phosphodiesterase", "gene_name": "SMPD1", "organism": "Bovine", "refseq_name": "sphingomyelin phosphodiesterase precursor", "refseq_ac": [ { "id": "NP_001068655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068655", "type": "external" } ], "gene_names_uniprotkb": "SMPD1", "gene_names_refseq": "ASM; SMPD1", "protein_names_uniprotkb": "Sphingomyelin phosphodiesterase; 3.1.4.12; 3.1.4.3; Acid sphingomyelinase; aSMase", "protein_names_refseq": "aSMase; acid sphingomyelinase; sphingomyelin phosphodiesterase precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:505097); (R-BTA-9769739); (R-BTA-9840310)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "20061541", "class_list": "", "function": "Acid sphingomyelinase activation serves as a triggering mechanism, leading to fusion of membrane proximal lysosomes into lipid rafts clusters on the cell membrane of coronary arterial endothelial cells., [RefSeq, PubMed]; Converts sphingomyelin to ceramide. Exists as two enzymatic forms that arise from alternative trafficking of a single protein precursor, one that is targeted to the endolysosomal compartment, whereas the other is released extracellularly. However, in response to various forms of stress, lysosomal exocytosis may represent a major source of the secretory form., [UniProtKB, UniProtKB]; In the lysosomes, converts sphingomyelin to ceramide. Plays an important role in the export of cholesterol from the intraendolysosomal membranes. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Modulates stress-induced apoptosis through the production of ceramide., [UniProtKB, UniProtKB]; This form is generated following cleavage by CASP7 in the extracellular milieu in response to bacterial infection (By similarity). It shows increased ability to convert sphingomyelin to ceramide and promotes plasma membrane repair. Plasma membrane repair by ceramide counteracts the action of gasdermin-D (GSDMD) perforin (PRF1) pores that are formed in response to bacterial infection (By similarity)., [UniProtKB, UniProtKB]; When secreted, modulates cell signaling with its ability to reorganize the plasma membrane by converting sphingomyelin to ceramide. Secreted form is increased in response to stress and inflammatory mediators such as IL1B, IFNG or TNF as well as upon infection with bacteria and viruses. Produces the release of ceramide in the outer leaflet of the plasma membrane playing a central role in host defense. Ceramide reorganizes these rafts into larger signaling platforms that are required to internalize bacteria, induce apoptosis and regulate the cytokine response in infected cells. In wounded cells, the lysosomal form is released extracellularly in the presence of Ca(2+) and promotes endocytosis and plasma membrane repair., [UniProtKB, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 6, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.12", "type": "external" }, { "id": "3.1.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.3", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004767 sphingomyelin phosphodiesterase activity;GO:0016798 hydrolase activity, acting on glycosyl bonds;GO:0061750 acid sphingomyelin phosphodiesterase activity;GO:0034480 phosphatidylcholine phospholipase C activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0005764 lysosome", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0034612 response to tumor necrosis factor;GO:0043065 positive regulation of apoptotic process;GO:0046513 ceramide biosynthetic process;GO:0071277 cellular response to calcium ion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q0VD19-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VD50-1", "uniprot_id": [ { "id": "NMNA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VD50", "type": "external" } ], "mass": 32200.0, "length": 281, "protein_name": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1", "gene_name": "NMNAT1", "organism": "Bovine", "refseq_name": "nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1", "refseq_ac": [ { "id": "NP_001069302", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069302", "type": "external" } ], "gene_names_uniprotkb": "NMNAT1", "gene_names_refseq": "NMNAT1", "protein_names_uniprotkb": "Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; 2.7.7.18; 2.7.7.1; NMN adenylyltransferase 1; NMN/NaMN adenylyltransferase 1; NaMN adenylyltransferase 1; Nicotinamide mononucleotide adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1", "protein_names_refseq": "NMN adenylyltransferase 1; NMN/NaMN adenylyltransferase 1; naMN adenylyltransferase 1; nicotinamide mononucleotide adenylyltransferase 1; nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:522863); (R-BTA-196807)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (By similarity). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (By similarity). Can use triazofurin monophosphate (TrMP) as substrate (By similarity). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (By similarity). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (By similarity). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (By similarity). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones. Protects against axonal degeneration following mechanical or toxic insults. Delays axonal degeneration after axotomy. Results in a >10-fold increase in intact neurites 72 hours after injury (By similarity). Neural protection does not correlate with cellular NAD(+) levels but may still require enzyme activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.1", "type": "external" }, { "id": "2.7.7.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0004515 nicotinate-nucleotide adenylyltransferase activity;GO:0000309 nicotinamide-nucleotide adenylyltransferase activity;GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body;GO:0000785 chromatin", "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:1990966 ATP generation from poly-ADP-D-ribose;GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VD50-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q0VD51-1", "uniprot_id": [ { "id": "RNF13_BOVIN", "url": "https://www.uniprot.org/uniprot/Q0VD51", "type": "external" } ], "mass": 42688.0, "length": 380, "protein_name": "E3 ubiquitin-protein ligase RNF13", "gene_name": "RNF13", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase RNF13 precursor", "refseq_ac": [ { "id": "NP_001069610", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069610", "type": "external" } ], "gene_names_uniprotkb": "RNF13", "gene_names_refseq": "RNF13", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF13; 2.3.2.27; RING finger protein 13", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF13 precursor; E3 ubiquitin-protein ligase RNF13; RING-type E3 ubiquitin transferase RNF13", "tax_id": 9913, "disease": "", "pathway": " (bta:539035)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that regulates cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. Also involved in protein trafficking and localization., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0008432 JUN kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0031902 late endosome membrane", "go_biological_process": "GO:0046330 positive regulation of JNK cascade;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0051865 protein autoubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q0VD51-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q11126-1", "uniprot_id": [ { "id": "FUT3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q11126", "type": "external" } ], "mass": 42654.0, "length": 365, "protein_name": "3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3", "gene_name": "FUT3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FUT3", "gene_names_refseq": "", "protein_names_uniprotkb": "3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3; 2.4.1.-; 2.4.1.152; 2.4.1.65; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; Alpha-3-fucosyltransferase FUT3; Blood group Lewis alpha-4-fucosyltransferase; FUTB; FucT-III; Fucosyltransferase 3; Fucosyltransferase III; Lewis FT", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 2, "publication_id_list": "10555285;9079712", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to both the subterminal N-acetyl glucosamine (GlcNAc) of type 1 chain (beta-D-Gal-(1->3)-beta-D-GlcNAc) glycolipids and oligosaccharides via an alpha(1,4) linkage, and the subterminal glucose (Glc) or GlcNAc of type 2 chain (beta-D-Gal-(1->4)-beta-D-GlcNAc) oligosaccharides via an alpha(1,3) linkage, independently of the presence of terminal alpha-L-fucosyl-(1,2) moieties on the terminal galactose of these acceptors and participates in the blood groups Lewis determination and expression of Lewis a (Le(a)), lewis b (Le(b)), Lewis x/SSEA-1 (Le(x)) and lewis y (Le(y)) antigens. Also catalyzes the transfer of L-fucose to subterminal GlcNAc of sialyl- and disialyl-lactotetraosylceramide to produce sialyl Lewis a (sLe(a)) and disialyl Lewis a via an alpha(1,4) linkage and therefore may regulate cell surface sialyl Lewis a expression and consequently regulates adhesive properties to E-selectin, cell proliferation and migration. Catalyzes the transfer of an L-fucose to 3'-sialyl-N-acetyllactosamine by an alpha(1,3) linkage, which allows the formation of sialyl-Lewis x structure and therefore may regulate the sialyl-Lewis x surface antigen expression and consequently adhesive properties to E-selectin. Prefers type 1 chain over type 2 acceptors. Type 1 tetrasaccharide is a better acceptor than type 1 disaccharide suggesting that a beta anomeric configuration of GlcNAc in the substrate is preferred. Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q4LDG4", "ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.65", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.65", "type": "external" }, { "id": "2.4.1.152", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.152", "type": "external" } ], "go_molecular_function": "GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity;GO:0017083 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity", "go_cellular_component": "GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0006629 lipid metabolic process;GO:0042127 regulation of cell population proliferation;GO:0006493 protein O-linked glycosylation;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 816, "hit_score": 0.3, "record_id": "Q11126-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QC0-1", "uniprot_id": [ { "id": "PGRC1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QC0", "type": "external" } ], "mass": 21622.0, "length": 194, "protein_name": "Membrane-associated progesterone receptor component 1", "gene_name": "PGRMC1", "organism": "Bovine", "refseq_name": "membrane-associated progesterone receptor component 1", "refseq_ac": [ { "id": "NP_001068601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068601", "type": "external" } ], "gene_names_uniprotkb": "PGRMC1", "gene_names_refseq": "PGRMC1; mPR", "protein_names_uniprotkb": "Membrane-associated progesterone receptor component 1; mPR", "protein_names_refseq": "membrane-associated progesterone receptor component 1", "tax_id": 9913, "disease": "", "pathway": " (bta:317706)", "pathway_count": 1, "publication_count": 9, "publication_id_list": "19092990;20739377;22073374;22277931;23325810;23522067;25168721;25319710;27260975", "class_list": "", "function": "Alterations in PGRMC1 and/or AURKB localization account in part for the increased aneuploidy and low development competence of oocytes from ovaries with reduced antral follicle counts. Publication Status: Online-Only, [RefSeq, PubMed]; Analysis of expression of progesterone receptor membrane component 1, serpine mRNA binding protein 1 and nuclear progesterone receptor isoforms A and B in the bovine myometrium during the estrous cycle and early pregnancy, [RefSeq, PubMed]; Component of a progesterone-binding protein complex. Binds progesterone (By similarity). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (By similarity). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data indicate variable expression of progesterone receptor membrane component 1 and 2 and serpine mRNA binding protein 1 mRNA and protein in bovine corpus luteum and suggest that progesterone may regulate corpus luteum function via its membrane receptors, [RefSeq, PubMed]; Endometrial mRNA level elevated during pregnancy is unchanged during estrous cycle, [RefSeq, PubMed]; PGRMC1 is expressed in bovine oocytes and its localization changes at specific stages of oocyte maturation, which may be specifically related to the mechanism by which chromosomes segregate., [RefSeq, PubMed]; PGRMC1 mRNA is expressed in bovine CL and this expression varies throughout the luteal phase. It is assumed that PGRMC1 may be involved in a non-genomic effect of P(4) on luteal cells., [RefSeq, PubMed]; PGRMC1 participates in late events of both mammalian mitosis and oocyte meiosis, consistent with PGRMC1's localization at the mid-zone and mid-body of the mitotic and meiotic spindle., [RefSeq, PubMed]; PGRMC1 protein expression and cellular distribution in cumulus cells, [RefSeq, PubMed]; With the exception of the corpora lutea, PGRMC1 localization showed similar pattern during different stages of the estrous cycle., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9N0T7", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0005496 steroid binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0012505 endomembrane system", "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0140077 positive regulation of lipoprotein transport;GO:1903537 meiotic cell cycle process involved in oocyte maturation", "synthesized_glycan_count": 0, "hit_score": 1.0, "record_id": "Q17QC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QD9-1", "uniprot_id": [ { "id": "CSEN_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QD9", "type": "external" } ], "mass": 29446.0, "length": 256, "protein_name": "Calsenilin", "gene_name": "KCNIP3", "organism": "Bovine", "refseq_name": "calsenilin", "refseq_ac": [ { "id": "NP_001069080", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069080", "type": "external" } ], "gene_names_uniprotkb": "KCNIP3; CSEN", "gene_names_refseq": "KCNIP3; KChIP3", "protein_names_uniprotkb": "Calsenilin; A-type potassium channel modulatory protein 3; KChIP3; Kv channel-interacting protein 3", "protein_names_refseq": "A-type potassium channel modulatory protein 3; Kv channel interacting protein 3, calsenilin; calsenilin; kv channel-interacting protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:513316)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity)., [UniProtKB, UniProtKB]; May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation (By similarity)., [UniProtKB, UniProtKB]; Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0005509 calcium ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0005267 potassium channel activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:1901379 regulation of potassium ion transmembrane transport;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0072659 protein localization to plasma membrane;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q17QD9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QF0-1", "uniprot_id": [ { "id": "AGT2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QF0", "type": "external" } ], "mass": 57226.0, "length": 514, "protein_name": "Alanine--glyoxylate aminotransferase 2, mitochondrial", "gene_name": "AGXT2", "organism": "Bovine", "refseq_name": "alanine--glyoxylate aminotransferase 2, mitochondrial", "refseq_ac": [ { "id": "NP_001069289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069289", "type": "external" } ], "gene_names_uniprotkb": "AGXT2", "gene_names_refseq": "AGXT2", "protein_names_uniprotkb": "Alanine--glyoxylate aminotransferase 2, mitochondrial; (R)-3-amino-2-methylpropionate--pyruvate transaminase; 2.6.1.18; 2.6.1.40; 2.6.1.44; AGT 2; Beta-ALAAT II; Beta-alanine-pyruvate aminotransferase; D-3-aminoisobutyrate-pyruvate aminotransferase; D-AIBAT; D-beta-aminoisobutyrate-pyruvate aminotransferase", "protein_names_refseq": "(R)-3-amino-2-methylpropionate--pyruvate transaminase; AGT 2; D-3-aminoisobutyrate-pyruvate aminotransferase; D-AIBAT; D-beta-aminoisobutyrate-pyruvate aminotransferase; alanine--glyoxylate aminotransferase 2, mitochondrial; beta-ALAAT II; beta-alanine-pyruvate aminotransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:521553)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multifunctional aminotransferase with a broad substrate specificity. Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor. Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine. Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate. Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.40", "type": "external" }, { "id": "2.6.1.44", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.44", "type": "external" }, { "id": "2.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.18", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0008453 alanine-glyoxylate transaminase activity;GO:0047305 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity;GO:0016223 beta-alanine:pyruvate transaminase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009436 glyoxylate catabolic process;GO:0019481 L-alanine catabolic process, by transamination;GO:2001299 N(omega),N(omega)-dimethyl-L-arginine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q17QF0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QI5-1", "uniprot_id": [ { "id": "VAMP7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QI5", "type": "external" } ], "mass": 24962.0, "length": 220, "protein_name": "Vesicle-associated membrane protein 7", "gene_name": "VAMP7", "organism": "Bovine", "refseq_name": "vesicle-associated membrane protein 7", "refseq_ac": [ { "id": "NP_001069770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069770", "type": "external" } ], "gene_names_uniprotkb": "VAMP7; SYBL1", "gene_names_refseq": "SYBL1; VAMP7", "protein_names_uniprotkb": "Vesicle-associated membrane protein 7; Synaptobrevin-like protein 1; VAMP-7", "protein_names_refseq": "synaptobrevin-like protein 1; vesicle-associated membrane protein 7", "tax_id": 9913, "disease": "", "pathway": " (bta:613984)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30573663", "class_list": "", "function": "Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0045202 synapse;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0030658 transport vesicle membrane", "go_biological_process": "GO:0006911 phagocytosis, engulfment;GO:0015031 protein transport;GO:0043312 neutrophil degranulation;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0008333 endosome to lysosome transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q17QI5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17QK9-1", "uniprot_id": [ { "id": "NAA60_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17QK9", "type": "external" } ], "mass": 27459.0, "length": 242, "protein_name": "N-alpha-acetyltransferase 60", "gene_name": "NAA60", "organism": "Bovine", "refseq_name": "N-alpha-acetyltransferase 60", "refseq_ac": [ { "id": "NP_001422360", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422360", "type": "external" } ], "gene_names_uniprotkb": "NAA60; NAT15", "gene_names_refseq": "HAT4; NAA60; NAT15; NatF", "protein_names_uniprotkb": "N-alpha-acetyltransferase 60; 2.3.1.259; 2.3.1.48; HAT4; Histone acetyltransferase type B protein 4; N-acetyltransferase 15; N-alpha-acetyltransferase F; NatF", "protein_names_refseq": "N-acetyltransferase 15 (GCN5-related, putative); N-alpha-acetyltransferase 60; N-alpha-acetyltransferase F; histone acetyltransferase type B protein 4; natF catalytic subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:514154)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "31874365", "class_list": "", "function": "N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol. Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met. Required for normal chromosomal segregation during anaphase. May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences., [UniProtKB, UniProtKB]; ZNF597 is a maternally expressed imprinted gene in the Holstein breed., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004402 histone acetyltransferase activity;GO:0010485 histone H4 acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0007059 chromosome segregation;GO:0008283 cell population proliferation;GO:0006334 nucleosome assembly;GO:0006474 N-terminal protein amino acid acetylation;GO:0017196 N-terminal peptidyl-methionine acetylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q17QK9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17R06-1", "uniprot_id": [ { "id": "RAB21_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17R06", "type": "external" } ], "mass": 24146.0, "length": 222, "protein_name": "Ras-related protein Rab-21", "gene_name": "RAB21", "organism": "Bovine", "refseq_name": "ras-related protein Rab-21", "refseq_ac": [ { "id": "NP_001068785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068785", "type": "external" } ], "gene_names_uniprotkb": "RAB21", "gene_names_refseq": "RAB21", "protein_names_uniprotkb": "Ras-related protein Rab-21; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-21", "tax_id": 9913, "disease": "", "pathway": " (bta:507488); (R-BTA-8873719); (R-BTA-8876198)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "30573663", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB21 is involved in membrane trafficking control (By similarity). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0019003 GDP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0032154 cleavage furrow", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0050821 protein stabilization;GO:0008089 anterograde axonal transport;GO:0050775 positive regulation of dendrite morphogenesis;GO:0048260 positive regulation of receptor-mediated endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q17R06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q17R14-1", "uniprot_id": [ { "id": "MYO1D_BOVIN", "url": "https://www.uniprot.org/uniprot/Q17R14", "type": "external" } ], "mass": 115939.0, "length": 1006, "protein_name": "Unconventional myosin-Id", "gene_name": "MYO1D", "organism": "Bovine", "refseq_name": "unconventional myosin-Id", "refseq_ac": [ { "id": "NP_001069306", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069306", "type": "external" } ], "gene_names_uniprotkb": "MYO1D", "gene_names_refseq": "MYO1D", "protein_names_uniprotkb": "Unconventional myosin-Id", "protein_names_refseq": "myosin-Id; unconventional myosin-Id", "tax_id": 9913, "disease": "", "pathway": " (bta:522967)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0048306 calcium-dependent protein binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005903 brush border", "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0030048 actin filament-based movement;GO:0061502 early endosome to recycling endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q17R14-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JP61-1", "uniprot_id": [ { "id": "KDM8_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JP61", "type": "external" } ], "mass": 45907.0, "length": 406, "protein_name": "Bifunctional peptidase and arginyl-hydroxylase JMJD5", "gene_name": "KDM8", "organism": "Bovine", "refseq_name": "bifunctional peptidase and arginyl-hydroxylase JMJD5", "refseq_ac": [ { "id": "NP_001068807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068807", "type": "external" } ], "gene_names_uniprotkb": "KDM8; JMJD5", "gene_names_refseq": "JMJD5; KDM8", "protein_names_uniprotkb": "Bifunctional peptidase and arginyl-hydroxylase JMJD5; 1.14.11.73; 3.4.-.-; JmjC domain-containing protein 5; Jumonji C domain-containing protein 5; L-arginine (3R)-hydroxylase KDM8", "protein_names_refseq": "L-arginine (3R)-hydroxylase KDM8; arginyl C3-hydroxylase KDM8; bifunctional peptidase and arginyl-hydroxylase JMJD5; jmjC domain-containing protein 5; jumonji C domain-containing protein 5; jumonji domain containing 5; jumonji domain-containing protein 5; lysine-specific demethylase 8", "tax_id": 9913, "disease": "", "pathway": " (bta:507905); (R-BTA-9629569)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monooxygenase. Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation. Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity. Upon DNA damage, cleaves the N-terminal tail of histone H3 at monomethylated lysine residues, preferably at monomethylated 'Lys-9' (H3K9me1). The histone variant H3F3A is the major target for cleavage. Additionally, acts as a Fe(2+) and 2-oxoglutarate-dependent monooxygenase, catalyzing (R)-stereospecific hydroxylation at C-3 of 'Arg-137' of RPS6 and 'Arg-141' of RCCD1, but the biological significance of this activity remains to be established. Regulates mitosis through different mechanisms: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with RCCD1. Possibly together with RCCD1, is involved in proper mitotic spindle organization and chromosome segregation. Negatively regulates cell cycle repressor CDKN1A/p21, which controls G1/S phase transition. Required for G2/M phase cell cycle progression. Regulates expression of CCNA1/cyclin-A1, leading to cancer cell proliferation. Also, plays a role in regulating alpha-tubulin acetylation and cytoskeletal microtubule stability involved in epithelial to mesenchymal transition (By similarity). Regulates the circadian gene expression in the liver (By similarity). Represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a catalytically-independent manner (By similarity). Negatively regulates the protein stability and function of CRY1; required for AMPK-FBXL3-induced CRY1 degradation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.73", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.73", "type": "external" }, { "id": "3.4.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-", "type": "external" } ], "go_molecular_function": "GO:0051864 histone H3K36 demethylase activity;GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0004177 aminopeptidase activity;GO:0106157 peptidyl-arginine 3-dioxygenase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006508 proteolysis;GO:0000086 G2/M transition of mitotic cell cycle;GO:0045892 negative regulation of DNA-templated transcription;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1JP61-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JPA0-1", "uniprot_id": [ { "id": "AL3B1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JPA0", "type": "external" } ], "mass": 51800.0, "length": 468, "protein_name": "Aldehyde dehydrogenase family 3 member B1", "gene_name": "ALDH3B1", "organism": "Bovine", "refseq_name": "aldehyde dehydrogenase family 3 member B1", "refseq_ac": [ { "id": "NP_001068986", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068986", "type": "external" } ], "gene_names_uniprotkb": "ALDH3B1", "gene_names_refseq": "ALDH3B1", "protein_names_uniprotkb": "Aldehyde dehydrogenase family 3 member B1; 1.2.1.28; 1.2.1.48; 1.2.1.5; 1.2.1.7; Aldehyde dehydrogenase 7; Long-chain fatty aldehyde dehydrogenase; Medium-chain fatty aldehyde dehydrogenase", "protein_names_refseq": "aldehyde dehydrogenase 3B1; aldehyde dehydrogenase 7; aldehyde dehydrogenase family 3 member B1; long-chain fatty aldehyde dehydrogenase; medium-chain fatty aldehyde dehydrogenase", "tax_id": 9913, "disease": "", "pathway": " (bta:511469); (R-BTA-6798695); (R-BTA-9845614)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids. May have a protective role against the cytotoxicity induced by lipid peroxidation. Short-chain fatty aldehydes are not good substrates. Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QLG7", "ec_number_list": [ { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.14.14.18", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18", "type": "external" }, { "id": "3.4.24.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "3.2.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" }, { "id": "1.6.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.-", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "3.4.21.73", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.73", "type": "external" }, { "id": "3.4.24.81", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" }, { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.14.19.17", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.17", "type": "external" }, { "id": "5.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0018479 benzaldehyde dehydrogenase (NAD+) activity;GO:0050061 long-chain fatty aldehyde dehydrogenase (NAD+) activity;GO:0052814 medium-chain fatty aldehyde dehydrogenase (NAD+) activity;GO:0018477 benzaldehyde dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006068 ethanol catabolic process;GO:0006081 aldehyde metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1JPA0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JPB9-1", "uniprot_id": [ { "id": "PA2G3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JPB9", "type": "external" } ], "mass": 55376.0, "length": 501, "protein_name": "Group 3 secretory phospholipase A2", "gene_name": "PLA2G3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PLA2G3", "gene_names_refseq": "", "protein_names_uniprotkb": "Group 3 secretory phospholipase A2; 3.1.1.4; GIII sPLA2; Group III secretory phospholipase A2; Phosphatidylcholine 2-acylhydrolase 3; sPLA2-III", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids without apparent head group selectivity (By similarity). Contributes to phospholipid remodeling of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (By similarity). May act in an autocrine and paracrine manner. Secreted by immature mast cells, acts on nearby fibroblasts upstream to PTDGS to synthesize prostaglandin D2 (PGD2), which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). Secreted by epididymal epithelium, acts on immature sperm cells within the duct, modulating the degree of unsaturation of the fatty acyl components of phosphatidylcholines required for acrosome assembly and sperm cell motility. Facilitates the replacement of fatty acyl chains in phosphatidylcholines in sperm membranes from omega-6 and omega-9 to omega-3 polyunsaturated fatty acids (PUFAs). Coupled to lipoxygenase pathway, may process omega-6 PUFAs to generate oxygenated lipid mediators in the male reproductive tract (By similarity). At pericentrosomal preciliary compartment, negatively regulates ciliogenesis likely by regulating endocytotic recycling of ciliary membrane protein (By similarity). Coupled to cyclooxygenase pathway provides arachidonate to generate prostaglandin E2 (PGE2), a potent immunomodulatory lipid in inflammation and tumorigenesis (By similarity). At colonic epithelial barrier, preferentially hydrolyzes phospholipids having arachidonate and docosahexaenoate at sn-2 position, contributing to the generation of oxygenated metabolites involved in colonic stem cell homeostasis (By similarity). Releases C16:0 and C18:0 lysophosphatidylcholine subclasses from neuron plasma membranes and promotes neurite outgrowth and neuron survival (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004623 phospholipase A2 activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0055037 recycling endosome;GO:0005814 centriole", "go_biological_process": "GO:0046473 phosphatidic acid metabolic process;GO:0010629 negative regulation of gene expression;GO:0010976 positive regulation of neuron projection development;GO:0050482 arachidonate secretion;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1JPB9-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JPD2-1", "uniprot_id": [ { "id": "ABHGA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JPD2", "type": "external" } ], "mass": 63304.0, "length": 558, "protein_name": "Phosphatidylserine lipase ABHD16A", "gene_name": "ABHD16A", "organism": "Bovine", "refseq_name": "phosphatidylserine lipase ABHD16A", "refseq_ac": [ { "id": "NP_001069073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069073", "type": "external" } ], "gene_names_uniprotkb": "ABHD16A; BAT5", "gene_names_refseq": "ABHD16A; BAT5", "protein_names_uniprotkb": "Phosphatidylserine lipase ABHD16A; 3.1.-.-; 3.1.1.23; Abhydrolase domain-containing protein 16A; Alpha/beta hydrolase domain-containing protein 16A; HLA-B-associated transcript 5 homolog; Monoacylglycerol lipase ABHD16A", "protein_names_refseq": "HLA-B associated transcript 5; HLA-B-associated transcript 5 homolog; abhydrolase domain-containing protein 16A; alpha/beta hydrolase domain-containing protein 16A; monoacylglycerol lipase ABHD16A; phosphatidylserine lipase ABHD16A; protein ABHD16A; protein BAT5", "tax_id": 9913, "disease": "", "pathway": " (bta:513252)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Phosphatidylserine (PS) lipase that mediates the hydrolysis of phosphatidylserine to generate lysophosphatidylserine (LPS). LPS constitutes a class of signaling lipids that regulates immunological and neurological processes (By similarity). Has no activity towards diacylglycerol, triacylglycerol or lysophosphatidylserine lipase (By similarity). Also has monoacylglycerol lipase activity, with preference for 1-(9Z,12Z-octadecadienoyl)-glycerol (1-LG) and 2-glyceryl-15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ(2)-G) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0047372 monoacylglycerol lipase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0052651 monoacylglycerol catabolic process;GO:0006660 phosphatidylserine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1JPD2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1JPD6-1", "uniprot_id": [ { "id": "STPAP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1JPD6", "type": "external" } ], "mass": 93811.0, "length": 871, "protein_name": "Speckle targeted PIP5K1A-regulated poly(A) polymerase", "gene_name": "TUT1", "organism": "Bovine", "refseq_name": "speckle targeted PIP5K1A-regulated poly(A) polymerase", "refseq_ac": [ { "id": "NP_001073791", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073791", "type": "external" } ], "gene_names_uniprotkb": "TUT1; RBM21", "gene_names_refseq": "RBM21; TUT1", "protein_names_uniprotkb": "Speckle targeted PIP5K1A-regulated poly(A) polymerase; 2.7.7.19; 2.7.7.52; RNA-binding motif protein 21; RNA-binding protein 21; Star-PAP; U6 snRNA-specific terminal uridylyltransferase 1; U6-TUTase", "protein_names_refseq": "RNA binding motif protein 21; RNA-binding protein 21; U6 snRNA-specific terminal uridylyltransferase 1; U6-TUTase; speckle targeted PIP5K1A-regulated poly(A) polymerase; star-PAP", "tax_id": 9913, "disease": "", "pathway": " (bta:616339)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0003730 mRNA 3'-UTR binding;GO:0050265 RNA uridylyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0016607 nuclear speck;GO:0005847 mRNA cleavage and polyadenylation specificity factor complex", "go_biological_process": "GO:0034477 U6 snRNA 3'-end processing;GO:0016180 snRNA processing;GO:0031123 RNA 3'-end processing;GO:0180010 co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1JPD6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZ86-1", "uniprot_id": [ { "id": "ABHD6_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZ86", "type": "external" } ], "mass": 38353.0, "length": 337, "protein_name": "Monoacylglycerol lipase ABHD6", "gene_name": "ABHD6", "organism": "Bovine", "refseq_name": "monoacylglycerol lipase ABHD6", "refseq_ac": [ { "id": "NP_001068664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068664", "type": "external" } ], "gene_names_uniprotkb": "ABHD6", "gene_names_refseq": "ABHD6", "protein_names_uniprotkb": "Monoacylglycerol lipase ABHD6; 2-arachidonoylglycerol hydrolase; 3.1.1.23; Abhydrolase domain-containing protein 6", "protein_names_refseq": "2-arachidonoylglycerol hydrolase; abhydrolase domain-containing protein 6; monoacylglycerol lipase ABHD6", "tax_id": 9913, "disease": "", "pathway": " (bta:505283); (R-BTA-426048)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (By similarity). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways. Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (By similarity). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism. BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0004620 phospholipase activity;GO:0047372 monoacylglycerol lipase activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0016020 membrane;GO:0031966 mitochondrial membrane;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:2001311 lysobisphosphatidic acid metabolic process;GO:0099178 regulation of retrograde trans-synaptic signaling by endocanabinoid;GO:0009395 phospholipid catabolic process;GO:0046464 acylglycerol catabolic process;GO:0046889 positive regulation of lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1LZ86-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZB0-1", "uniprot_id": [ { "id": "DDRGK_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZB0", "type": "external" } ], "mass": 35667.0, "length": 313, "protein_name": "DDRGK domain-containing protein 1", "gene_name": "DDRGK1", "organism": "Bovine", "refseq_name": "DDRGK domain-containing protein 1", "refseq_ac": [ { "id": "NP_001068966", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068966", "type": "external" } ], "gene_names_uniprotkb": "DDRGK1", "gene_names_refseq": "C13H20ORF116; DDRGK1", "protein_names_uniprotkb": "DDRGK domain-containing protein 1", "protein_names_refseq": "DDRGK domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:511144)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the UFM1 ribosome E3 ligase (UREL) complex, a multiprotein complex that catalyzes ufmylation of endoplasmic reticulum-docked proteins. The UREL complex plays a key role in ribosome recycling by mediating mono-ufmylation of the RPL26/uL24 subunit of the 60S ribosome following ribosome dissociation: ufmylation weakens the junction between post-termination 60S subunits and SEC61 translocons, promoting release and recycling of the large ribosomal subunit from the endoplasmic reticulum membrane. Ufmylation of RPL26/uL24 and subsequent 60S ribosome recycling either take place after normal termination of translation or after ribosome stalling during cotranslational translocation at the endoplasmic reticulum. Within the UREL complex, DDRGK1 tethers the complex to the endoplasmic reticulum membrane to restrict its activity to endoplasmic reticulum-docked ribosomes and acts as an ufmylation 'reader': following RPL26/uL24 ufmylation, DDRGK1 specifically binds to ufmylated RPL26/uL24 via its UFIM motif, resulting in stable association between the 60S ribosome and the UREL complex, followed by dissociation of the 60S ribosome subunit from the endoplasmic reticulum membrane. The UREL complex is also involved in reticulophagy in response to endoplasmic reticulum stress by promoting ufmylation of proteins such as CYB5R3 and RPN1, thereby promoting lysosomal degradation of ufmylated proteins. Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR) by regulating ERN1/IRE1-alpha stability (By similarity). Acts as a regulator of immunity by promoting differentiation of B-cells into plasma cells: acts by promoting expansion of the endoplasmic reticulum and regulating the unfolded protein response (UPR) (By similarity). May also be required for TRIP4 ufmylation. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B. Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator (By similarity). Required for stabilization and ufmylation of ATG9A (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044389 ubiquitin-like protein ligase binding;GO:0141185 UFM1-modified protein reader activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0072344 rescue of stalled ribosome;GO:0032790 ribosome disassembly;GO:0031647 regulation of protein stability;GO:1903721 positive regulation of I-kappaB phosphorylation;GO:0070972 protein localization to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1LZB0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1LZB6-1", "uniprot_id": [ { "id": "CAPR1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1LZB6", "type": "external" } ], "mass": 78328.0, "length": 708, "protein_name": "Caprin-1", "gene_name": "CAPRIN1", "organism": "Bovine", "refseq_name": "caprin-1", "refseq_ac": [ { "id": "NP_001069530", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069530", "type": "external" } ], "gene_names_uniprotkb": "CAPRIN1; RNG105", "gene_names_refseq": "CAPRIN1", "protein_names_uniprotkb": "Caprin-1; Cytoplasmic activation- and proliferation-associated protein 1; RNA granule protein 105", "protein_names_refseq": "RNA granule protein 105; caprin-1; cytoplasmic activation- and proliferation-associated protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:535571)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types. Plays an essential role in cytoplasmic stress granule formation (By similarity). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs. In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation. Binds directly and selectively to MYC and CCND2 mRNAs. In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0035591 signaling adaptor activity;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030027 lamellipodium;GO:0030425 dendrite;GO:0031252 cell leading edge", "go_biological_process": "GO:0030154 cell differentiation;GO:0017148 negative regulation of translation;GO:0050775 positive regulation of dendrite morphogenesis;GO:0061003 positive regulation of dendritic spine morphogenesis;GO:0062029 positive regulation of stress granule assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1LZB6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RML2-1", "uniprot_id": [ { "id": "PLCZ1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RML2", "type": "external" } ], "mass": 73732.0, "length": 634, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1", "gene_name": "PLCZ1", "organism": "Bovine", "refseq_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1", "refseq_ac": [ { "id": "NP_001011680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011680", "type": "external" } ], "gene_names_uniprotkb": "PLCZ1; PLCZ", "gene_names_refseq": "PLCZ1; PLCZ", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; 3.1.4.11; PLC-zeta-1; Phosphoinositide phospholipase C-zeta-1; Phospholipase C-zeta-1", "protein_names_refseq": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1; PLC-zeta-1; phosphoinositide phospholipase C-zeta-1", "tax_id": 9913, "disease": "", "pathway": " (bta:497026); (R-BTA-1855204)", "pathway_count": 2, "publication_count": 6, "publication_id_list": "15744020;18284699;20357268;25501200;28929980;33572865", "class_list": "", "function": "A novel splice variant of Phospholipase C zeta 1 in the testis tissues of adult and fetal Chinese Holstein bulls was characterized. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that the level of actin/PLC-zeta interaction was twice as high in G-actin that reflected an increase in affinity., [RefSeq, PubMed]; Intracytoplasmic Sperm Injection in Cattle. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Murine PLCZ1 and bovine PLCZ1 possess species-specific differences in activity and suggest potential differences in the mode of action of the protein between the two species, [RefSeq, PubMed]; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q5IT24", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process;GO:0007343 egg activation;GO:0060470 positive regulation of cytosolic calcium ion concentration involved in egg activation", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q1RML2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMR5-1", "uniprot_id": [ { "id": "DAA11_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMR5", "type": "external" } ], "mass": 54542.0, "length": 472, "protein_name": "Dynein axonemal assembly factor 11", "gene_name": "DNAAF11", "organism": "Bovine", "refseq_name": "dynein axonemal assembly factor 11", "refseq_ac": [ { "id": "NP_001069372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069372", "type": "external" } ], "gene_names_uniprotkb": "DNAAF11; LRRC6; LRTP; TSLRP", "gene_names_refseq": "DNAAF11; LRRC6", "protein_names_uniprotkb": "Dynein axonemal assembly factor 11; DNAAF11; Leucine-rich repeat-containing protein 6; Leucine-rich testis-specific protein; Protein tilB homolog; Testis-specific leucine-rich repeat protein", "protein_names_refseq": "dynein axonemal assembly factor 11; leucine rich repeat containing 6; leucine-rich repeat-containing protein 6; leucine-rich testis-specific protein; protein TILB homolog; testis-specific leucine-rich repeat protein", "tax_id": 9913, "disease": "", "pathway": " (bta:527979)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Involved in dynein arm assembly, is important for expression and transporting outer dynein arm (ODA) proteins from the cytoplasm to the cilia. Acts as a crucial component in the formation and motility of spermatozoal flagella., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031514 motile cilium;GO:0090651 apical cytoplasm", "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0030317 flagellated sperm motility;GO:0008584 male gonad development;GO:0044458 motile cilium assembly;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q1RMR5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q1RMT8-1", "uniprot_id": [ { "id": "IRAK4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q1RMT8", "type": "external" } ], "mass": 51575.0, "length": 461, "protein_name": "Interleukin-1 receptor-associated kinase 4", "gene_name": "IRAK4", "organism": "Bovine", "refseq_name": "interleukin-1 receptor-associated kinase 4", "refseq_ac": [ { "id": "NP_001069466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069466", "type": "external" } ], "gene_names_uniprotkb": "IRAK4", "gene_names_refseq": "IRAK-4; IRAK4", "protein_names_uniprotkb": "Interleukin-1 receptor-associated kinase 4; 2.7.11.1; IRAK-4", "protein_names_refseq": "NY-REN-64 antigen; interleukin-1 receptor-associated kinase 4", "tax_id": 9913, "disease": "", "pathway": " (bta:533692); (R-BTA-1257604); (R-BTA-6811558); (R-BTA-9020702)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0005149 interleukin-1 receptor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0035556 intracellular signal transduction;GO:0045087 innate immune response;GO:0002446 neutrophil mediated immunity;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q1RMT8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24K02-1", "uniprot_id": [ { "id": "IDE_BOVIN", "url": "https://www.uniprot.org/uniprot/Q24K02", "type": "external" } ], "mass": 118102.0, "length": 1019, "protein_name": "Insulin-degrading enzyme", "gene_name": "IDE", "organism": "Bovine", "refseq_name": "insulin-degrading enzyme", "refseq_ac": [ { "id": "NP_001069317", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001069317", "type": "external" } ], "gene_names_uniprotkb": "IDE", "gene_names_refseq": "IDE", "protein_names_uniprotkb": "Insulin-degrading enzyme; 3.4.24.56; Insulin protease; Insulinase; Insulysin", "protein_names_refseq": "insulin protease; insulin-degrading enzyme; insulinase; insulysin", "tax_id": 9913, "disease": "", "pathway": " (bta:523752); (R-BTA-5689880); (R-BTA-77387); (R-BTA-9033241)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the cellular breakdown of insulin, APP peptides, IAPP peptides, natriuretic peptides, glucagon, bradykinin, kallidin, and other peptides, and thereby plays a role in intercellular peptide signaling (By similarity). Substrate binding induces important conformation changes, making it possible to bind and degrade larger substrates, such as insulin (By similarity). Contributes to the regulation of peptide hormone signaling cascades and regulation of blood glucose homeostasis via its role in the degradation of insulin, glucagon and IAPP. Plays a role in the degradation and clearance of APP-derived amyloidogenic peptides that are secreted by neurons and microglia (By similarity). Degrades the natriuretic peptides ANP, BNP and CNP, inactivating their ability to raise intracellular cGMP (By similarity). Also degrades an aberrant frameshifted 40-residue form of NPPA (fsNPPA) which is associated with familial atrial fibrillation in heterozygous patients (By similarity). Involved in antigen processing. Produces both the N terminus and the C terminus of MAGEA3-derived antigenic peptide (EVDPIGHLY) that is presented to cytotoxic T lymphocytes by MHC class I (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "1.1.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.3.15", "type": "external" }, { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "4.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.17", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "1.4.3.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.3", "type": "external" }, { "id": "1.5.3.13", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.13", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "1.3.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.38", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.176", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.176", "type": "external" }, { "id": "2.3.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16", "type": "external" }, { "id": "2.3.1.155", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155", "type": "external" }, { "id": "4.1.2.63", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.63", "type": "external" }, { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27", "type": "external" }, { "id": "3.1.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1", "type": "external" }, { "id": "3.1.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11", "type": "external" }, { "id": "3.1.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3", "type": "external" }, { "id": "3.1.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.24.56", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.56", "type": "external" }, { "id": "4.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.4", "type": "external" }, { "id": "1.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.1", "type": "external" }, { "id": "1.5.3.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.3.7", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "1.3.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.3.6", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0005782 peroxisomal matrix;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0050435 amyloid-beta metabolic process;GO:0042447 hormone catabolic process;GO:0043171 peptide catabolic process;GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I;GO:0030163 protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q24K02-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q24K09-1", "uniprot_id": [ { "id": "DNMT1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q24K09", "type": "external" } ], "mass": 182842.0, "length": 1611, "protein_name": "DNA (cytosine-5)-methyltransferase 1", "gene_name": "DNMT1; EIF3G", "organism": "Bovine", "refseq_name": "DNA (cytosine-5)-methyltransferase 1", "refseq_ac": [ { "id": "NP_872592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_872592", "type": "external" } ], "gene_names_uniprotkb": "DNMT1; EIF3G; DNMT1; EIF3S4", "gene_names_refseq": "DNMT1; DNMT", "protein_names_uniprotkb": "DNA (cytosine-5)-methyltransferase 1; 2.1.1.37; Dnmt1", "protein_names_refseq": "DNA (cytosine 5) methyltransferase 1; DNA (cytosine-5)-methyltransferase 1; DNA methyltransferase (cytosine 5) methyltransferase; DNA methyltransferase b", "tax_id": 9913, "disease": "", "pathway": " (bta:281119); (R-BTA-156827); (R-BTA-212300); (R-BTA-4655427); (R-BTA-72649); (R-BTA-72689); (R-BTA-72695); (R-BTA-72702)", "pathway_count": 8, "publication_count": 8, "publication_id_list": "12971987;18199878;18297739;19567221;21480430;24675837;24987964;27766427", "class_list": "", "function": "Abnormal gene expression of DNMT, INFT, and MHC1 was noted in the majority of cloned embryos, indicating inefficient nuclear reprogramming and retarded embryo development., [RefSeq, PubMed]; DNA methyltransferase that methylates CpG residues. Preferentially methylates hemimethylated DNA. Associates with DNA replication sites in S phase maintaining the methylation pattern in the newly synthesized strand, that is essential for epigenetic inheritance. Associates with chromatin during G2 and M phases to maintain DNA methylation independently of replication. It is responsible for maintaining methylation patterns established in development. DNA methylation is coordinated with methylation of histones. Mediates transcriptional repression by direct binding to HDAC2. In association with DNMT3B and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing., [UniProtKB, UniProtKB]; DNMT1 silencing significantly decreased the methylation levels of miR-29b promoter, up-regulated miR-29b expression and inhibited bovine viral diarrhea virus replication., [RefSeq, PubMed]; More DNMT1 mRNA was detected in the transgenic somatic cell nuclear transfer (SCNT) group than the other three groups. Hsp 70.1 mRNA was detected in the in vitro fertilzation embryos. Mash2 mRNA was present at highest levels in transgenic SCNT embryos., [RefSeq, PubMed]; Our results indicate an essential role for Dnmt1 during bovine preimplantation development, and suggest proper transcriptional reprogramming of this gene family in SCNT embryos., [RefSeq, PubMed]; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. This subunit can bind 18S rRNA., [UniProtKB, HAMAP, UniProtKB]; Report inhibition of DNA methyltransferase 1 expression in bovine fibroblast cells used for nuclear transfer., [RefSeq, PubMed]; Results describe the alternative splicing and expression analysis of bovine DNA methyltransferase 1., [RefSeq, PubMed]; Through down-regulating the expression of DNMT1, miR-152 reduced Global DNA methylation and the activity of DNMT to reactivate the lactation signal transduction genes Akt and Ppar gamma. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 16, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6Y856;Q7YS60", "ec_number_list": [ { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" }, { "id": "2.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.37", "type": "external" } ], "go_molecular_function": "GO:0003886 DNA (cytosine-5-)-methyltransferase activity;GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:1990841 promoter-specific chromatin binding;GO:0140254 histone H3K18ub reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000792 heterochromatin;GO:0005654 nucleoplasm;GO:0048471 perinuclear region of cytoplasm;GO:0005657 replication fork", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032259 methylation;GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation;GO:0141119 chromosomal DNA methylation maintenance following DNA replication;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q24K09-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27958-1", "uniprot_id": [ { "id": "DPOLB_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27958", "type": "external" } ], "mass": 38267.0, "length": 335, "protein_name": "DNA polymerase beta", "gene_name": "POLB", "organism": "Bovine", "refseq_name": "DNA polymerase beta", "refseq_ac": [ { "id": "NP_001029936", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029936", "type": "external" } ], "gene_names_uniprotkb": "POLB", "gene_names_refseq": "POLB", "protein_names_uniprotkb": "DNA polymerase beta; 2.7.7.7; 4.2.99.-; 4.2.99.18; 5'-dRP lyase; 5'-deoxyribose-phosphate lyase; AP lyase", "protein_names_refseq": "5'-dRP lyase; 5'-deoxyribose-phosphate lyase; AP lyase; DNA polymerase beta; DNA-directed DNA polymerase beta; polymerase (DNA directed), beta", "tax_id": 9913, "disease": "", "pathway": " (bta:614688); (R-BTA-110362); (R-BTA-110373); (R-BTA-110381); (R-BTA-5649702); (R-BTA-5651801); (R-BTA-5689880); (R-BTA-73930)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "7590351", "class_list": "", "function": "DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity., [UniProtKB, UniProtKB]; Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3ZBL6", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" }, { "id": "3.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005876 spindle microtubule;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006284 base-excision repair;GO:0006974 DNA damage response;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0006261 DNA-templated DNA replication;GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q27958-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27960-1", "uniprot_id": [ { "id": "NPT2B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27960", "type": "external" } ], "mass": 75826.0, "length": 693, "protein_name": "Sodium-dependent phosphate transport protein 2B", "gene_name": "SLC34A2", "organism": "Bovine", "refseq_name": "sodium-dependent phosphate transport protein 2B", "refseq_ac": [ { "id": "NP_777086", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777086", "type": "external" } ], "gene_names_uniprotkb": "SLC34A2", "gene_names_refseq": "SLC34A2", "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 2B; Na(+)-dependent phosphate cotransporter 2B; Na(+)/Pi cotransporter 2B; NaPi-2b; Sodium-phosphate transport protein 2B; Sodium/phosphate cotransporter 2B; Solute carrier family 34 member 2", "protein_names_refseq": "Na(+)-dependent phosphate cotransporter 2B; Na(+)/Pi cotransporter 2B; naPi-2b; sodium-dependent phosphate transport protein 2B; sodium-phosphate transport protein 2B; sodium/phosphate cotransporter 2B; solute carrier family 34 (sodium phosphate), member 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282484)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1915351;7737195", "class_list": "", "function": "Involved in actively transporting phosphate into cells via Na(+) cotransport., [UniProtKB, PubMed, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042301 phosphate ion binding;GO:0031402 sodium ion binding;GO:0005436 sodium:phosphate symporter activity", "go_cellular_component": "GO:0005903 brush border;GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0031982 vesicle", "go_biological_process": "GO:0006817 phosphate ion transport;GO:0030643 intracellular phosphate ion homeostasis;GO:0044341 sodium-dependent phosphate transport", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q27960-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27963-1", "uniprot_id": [ { "id": "VMAT2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27963", "type": "external" } ], "mass": 55756.0, "length": 517, "protein_name": "Synaptic vesicular amine transporter", "gene_name": "SLC18A2", "organism": "Bovine", "refseq_name": "synaptic vesicular amine transporter", "refseq_ac": [ { "id": "NP_777078", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777078", "type": "external" } ], "gene_names_uniprotkb": "SLC18A2; VMAT2", "gene_names_refseq": "SLC18A2", "protein_names_uniprotkb": "Synaptic vesicular amine transporter; Monoamine transporter; Solute carrier family 18 member 2; VAT2; Vesicular amine transporter 2; Vesicular monoamine transporter 2", "protein_names_refseq": "VAT2; monoamine transporter; solute carrier family 18 (vesicular monoamine), member 2; solute carrier family 18 member 2; synaptic vesicular amine transporter; vesicular amine transporter 2; vesicular monoamine transporter 2", "tax_id": 9913, "disease": "", "pathway": " (bta:282471)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "1357668;7902299;8307150", "class_list": "", "function": "Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed:8307150). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q28211", "ec_number_list": [], "go_molecular_function": "GO:0005335 serotonin:sodium:chloride symporter activity;GO:0015311 monoamine:proton antiporter activity", "go_cellular_component": "GO:0030424 axon;GO:0030425 dendrite;GO:0043195 terminal bouton;GO:0030667 secretory granule membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0035864 response to potassium ion;GO:0090494 dopamine uptake;GO:0051610 serotonin uptake;GO:0015842 aminergic neurotransmitter loading into synaptic vesicle;GO:0099123 somato-dendritic dopamine secretion", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q27963-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27970-1", "uniprot_id": [ { "id": "CAN1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27970", "type": "external" } ], "mass": 82207.0, "length": 716, "protein_name": "Calpain-1 catalytic subunit", "gene_name": "CAPN1", "organism": "Bovine", "refseq_name": "calpain-1 catalytic subunit", "refseq_ac": [ { "id": "NP_776684", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776684", "type": "external" } ], "gene_names_uniprotkb": "CAPN1", "gene_names_refseq": "CANP 1; CANP1; CAPN1", "protein_names_uniprotkb": "Calpain-1 catalytic subunit; 3.4.22.52; CANP 1; Calcium-activated neutral proteinase 1; Calpain mu-type; Calpain-1 large subunit; Micromolar-calpain; muCANP", "protein_names_refseq": "calcium activated neutral protease 1; calcium-activated neutral proteinase 1; calpain 1, (mu/I) large subunit; calpain mu-type; calpain-1 catalytic subunit; calpain-1 large subunit; micromolar calcium-activated neutral protease 1; micromolar-calpain; mu-calpain; muCANP", "tax_id": 9913, "disease": "", "pathway": " (bta:281661); (R-BTA-1474228); (R-BTA-6798695)", "pathway_count": 3, "publication_count": 8, "publication_id_list": "11048924;14622253;2065086;25215589;25414103;26946475;27107033;29448132", "class_list": "", "function": "Bovine CAPN-CAST interaction were well reflected in the geometry between the pharmacophore features and its shape constraints identified using our modeled bovine CAPN1/CAST4 complex structures Publication Status: Online-Only, [RefSeq, PubMed]; Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1. Cleaves and activates caspase-7 (CASP7)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Investigation of calpain 1 binding with alpha-actinin; propose that calpain 1 interacts in a resting state with cytoskeletal targets, [RefSeq, PubMed]; Most heifer reproductive traits were not significantly affected by CAST and CAPN1 markers that are widely used to improve beef tenderness by selection and breeders should not be concerned with how these markers affect reproduction and other heifer traits with the possible exception of CAPN1 effects on calving date., [RefSeq, PubMed]; Study is the first report on genetic variant g.-1256 A>C in the promoter region of CAPN1 gene association with the semen quality of Chinese Holstein bulls by influencing its expression, [RefSeq, PubMed]; These results suggest an important role of genetics in meat color variation for cattle raised under the tropic conditions., [RefSeq, PubMed]; This work is supportive of the importance of CAPN1 and CAST for mean tenderness in beef., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9N0U3;Q9N0V6;Q9N185", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "3.4.22.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.53", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0004198 calcium-dependent cysteine-type endopeptidase activity;GO:0005509 calcium ion binding;GO:0008233 peptidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005739 mitochondrion;GO:0005764 lysosome", "go_biological_process": "GO:0006508 proteolysis;GO:0050790 regulation of catalytic activity;GO:0097264 self proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q27970-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27987-1", "uniprot_id": [ { "id": "TSHR_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27987", "type": "external" } ], "mass": 86431.0, "length": 763, "protein_name": "Thyrotropin receptor", "gene_name": "TSHR", "organism": "Bovine", "refseq_name": "thyrotropin receptor precursor", "refseq_ac": [ { "id": "NP_776631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776631", "type": "external" } ], "gene_names_uniprotkb": "TSHR", "gene_names_refseq": "TSHR", "protein_names_uniprotkb": "Thyrotropin receptor; TSH-R; Thyroid-stimulating hormone receptor", "protein_names_refseq": "TSH-R; thyrotropin receptor precursor; thyrotropin receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:281553)", "pathway_count": 1, "publication_count": 6, "publication_id_list": "15722344;17556863;18202525;18441013;19553036;9134497", "class_list": "", "function": "Analysis of activation switch in the thyrotropin receptor, [RefSeq, PubMed]; Increased receptor binding by bovine (b) TSH bound to monoclonal antibody to bTSHbeta-subunit., [RefSeq, PubMed]; Localization of thyrotropin receptor and thyroglobulin in the bovine corpus luteum., [RefSeq, PubMed]; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS) (By similarity). Additionally, plays a central role in controlling thyroid cell metabolism (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Rhes can interfere with the functional activity of wt and mutated TSHr., [RefSeq, PubMed]; The hinge region represents an extracellular intermediate connector for both hormone binding and signal transduction of the thyroid stimulating hormone receptor, [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q27986", "ec_number_list": [], "go_molecular_function": "GO:0004996 thyroid-stimulating hormone receptor activity;GO:0044877 protein-containing complex binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane", "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0009755 hormone-mediated signaling pathway;GO:0038194 thyroid-stimulating hormone signaling pathway;GO:1904588 cellular response to glycoprotein", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q27987-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27994-1", "uniprot_id": [ { "id": "GLUT4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27994", "type": "external" } ], "mass": 55084.0, "length": 509, "protein_name": "Solute carrier family 2, facilitated glucose transporter member 4", "gene_name": "SLC2A4", "organism": "Bovine", "refseq_name": "solute carrier family 2, facilitated glucose transporter member 4", "refseq_ac": [ { "id": "NP_777029", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777029", "type": "external" } ], "gene_names_uniprotkb": "SLC2A4; GLUT4", "gene_names_refseq": "GLUT4; SLC2A4", "protein_names_uniprotkb": "Solute carrier family 2, facilitated glucose transporter member 4; GLUT-4; Glucose transporter type 4, insulin-responsive", "protein_names_refseq": "GLUT-4; glucose transporter type 4, insulin-responsive; solute carrier family 2 (facilitated glucose transporter), member 4; solute carrier family 2, facilitated glucose transporter member 4", "tax_id": 9913, "disease": "", "pathway": " (bta:282359); (R-BTA-189200)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "21605761;24906930;26723114;8925410;9027564", "class_list": "", "function": "GLUT4 gene expression increased during late lactation., [RefSeq, PubMed]; Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell., [UniProtKB, UniProtKB]; Low GLUT1 and GLUT3 expression in nonclassical monocytes was unaltered during differentiation into macrophages. GLUT4 mRNA was only detectable in unstimulated macrophages. Neither monocytes nor macrophages were insulin responsive., [RefSeq, PubMed]; Results of the present study suggest that myostatin inhibits the expression of GLUT4 mRNA and that the greater ability of double muscled cattle to produce muscle may be due to their greater sensitivity to insulin and greater use of glucose., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "P79104;Q29RP5;Q6SI69", "ec_number_list": [], "go_molecular_function": "GO:0055056 D-glucose transmembrane transporter activity;GO:0015304 D-glucose uniporter activity", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045121 membrane raft;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0070837 dehydroascorbic acid transport;GO:1904659 D-glucose transmembrane transport;GO:0032869 cellular response to insulin stimulus;GO:0044381 glucose import in response to insulin stimulus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q27994-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27995-1", "uniprot_id": [ { "id": "NOS2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27995", "type": "external" } ], "mass": 131208.0, "length": 1156, "protein_name": "Nitric oxide synthase, inducible", "gene_name": "NOS2", "organism": "Bovine", "refseq_name": "nitric oxide synthase, inducible", "refseq_ac": [ { "id": "NP_001070267", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070267", "type": "external" } ], "gene_names_uniprotkb": "NOS2", "gene_names_refseq": "NOS2A; NOS2; iNOS", "protein_names_uniprotkb": "Nitric oxide synthase, inducible; 1.14.13.39; Inducible NO synthase; Inducible NOS; NOS type II; NOSII; Peptidyl-cysteine S-nitrosylase NOS2; iNOS", "protein_names_refseq": "NOS type II; NOSII; inducible NO synthase; inducible NOS; inducible nitric oxide synthase; nitric oxide synthase 2, inducible; nitric oxide synthase 2A (inducible, hepatocytes); nitric oxide synthase, inducible; peptidyl-cysteine S-nitrosylase NOS2", "tax_id": 9913, "disease": "", "pathway": " (bta:282876)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "16207333;21414188;22921266;23410122;24597304;26468216;7536776;7558036", "class_list": "", "function": "Data suggest that the transcriptional inducible NOS response to octacalcium phosphate crystals involved both the p38 and the JNK MAPK pathways, probably under the control of activator protein-1, [RefSeq, PubMed]; Differential cell-specific and spatiotemporal expression of the EDN1 system and NOS in the bovine utero-placental unit may be associated with regulation of vascular and cellular functions during pregnancy., [RefSeq, PubMed]; Polymorphism of the NOS2 gene may contribute to the susceptibility of Holstein cattle to bovine tuberculosis, [RefSeq, PubMed]; Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8., [UniProtKB, UniProtKB, UniProtKB]; The expression, localization, and distribution of 3 nitric oxide synthase enzymes through the estrous cycle in bovien fallopian tubes are reported., [RefSeq, PubMed]; These results provide evidence for a high prevalence of subclinical endometritis in repeat breeding cows as well as the involvement of TNFalpha and iNOS pathways in the regulation of this pathological condition., [RefSeq, PubMed]; Vitamin D receptor activation, and inducible nitric oxide synthase (NOS2), were strongly induced during Cooperia oncophora reinfection. Several canonical pathways associated with NOS2 were impacted. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q06Q84;Q27985", "ec_number_list": [ { "id": "1.14.13.39", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39", "type": "external" } ], "go_molecular_function": "GO:0004517 nitric-oxide synthase activity;GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0050660 flavin adenine dinucleotide binding;GO:0020037 heme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0018119 peptidyl-cysteine S-nitrosylation;GO:0032496 response to lipopolysaccharide;GO:0032755 positive regulation of interleukin-6 production;GO:0045776 negative regulation of blood pressure", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q27995-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q27ID4-1", "uniprot_id": [ { "id": "TERT_BOVIN", "url": "https://www.uniprot.org/uniprot/Q27ID4", "type": "external" } ], "mass": 124447.0, "length": 1125, "protein_name": "Telomerase reverse transcriptase", "gene_name": "TERT", "organism": "Bovine", "refseq_name": "telomerase reverse transcriptase", "refseq_ac": [ { "id": "NP_001039707", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039707", "type": "external" } ], "gene_names_uniprotkb": "TERT", "gene_names_refseq": "TERT", "protein_names_uniprotkb": "Telomerase reverse transcriptase; 2.7.7.49; Telomerase catalytic subunit", "protein_names_refseq": "telomerase catalytic subunit; telomerase reverse transcriptase", "tax_id": 9913, "disease": "", "pathway": " (bta:518884)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "22855562;31269352;34070219;34830422", "class_list": "", "function": "Constitutive Expression of TERT Enhances beta-Klotho Expression and Improves Age-Related Deterioration in Early Bovine Embryos. Publication Status: Online-Only, [RefSeq, PubMed]; Ectopic expression of human telomerase RNA component results in increased telomerase activity and elongated telomeres in bovine blastocysts. Publication Status: Online-Only, [RefSeq, PubMed]; Establishment of an Efficient Immortalization Strategy Using HMEJ-Based bTERT Insertion for Bovine Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Telomerase activity in cattle affected with enzootic bovine leucosis is reported., [RefSeq, PubMed]; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0042162 telomeric DNA binding;GO:0003720 telomerase activity;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0016605 PML body;GO:0005697 telomerase holoenzyme complex;GO:0000781 chromosome, telomeric region", "go_biological_process": "GO:0007004 telomere maintenance via telomerase", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q27ID4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28007-1", "uniprot_id": [ { "id": "DPYD_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28007", "type": "external" } ], "mass": 111697.0, "length": 1025, "protein_name": "Dihydropyrimidine dehydrogenase [NADP(+)]", "gene_name": "DPYD", "organism": "Bovine", "refseq_name": "dihydropyrimidine dehydrogenase [NADP(+)]", "refseq_ac": [ { "id": "NP_776466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776466", "type": "external" } ], "gene_names_uniprotkb": "DPYD", "gene_names_refseq": "DPYD", "protein_names_uniprotkb": "Dihydropyrimidine dehydrogenase [NADP(+)]; 1.3.1.2; DHPDHase; DPD; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase", "protein_names_refseq": "DHPDHase; DPD; dihydropyrimidine dehydrogenase [NADP(+)]; dihydrothymine dehydrogenase; dihydrouracil dehydrogenase", "tax_id": 9913, "disease": "", "pathway": " (bta:281124)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "1939061;8912928", "class_list": "", "function": "Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q9TRV4", "ec_number_list": [ { "id": "1.3.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.2", "type": "external" } ], "go_molecular_function": "GO:0002058 uracil binding;GO:0017113 dihydropyrimidine dehydrogenase (NADP+) activity;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006210 thymine catabolic process;GO:0006212 uracil catabolic process;GO:0006214 thymidine catabolic process;GO:0019483 beta-alanine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q28007-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28017-1", "uniprot_id": [ { "id": "PAFA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28017", "type": "external" } ], "mass": 50133.0, "length": 444, "protein_name": "Platelet-activating factor acetylhydrolase", "gene_name": "PLA2G7", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PLA2G7", "gene_names_refseq": "", "protein_names_uniprotkb": "Platelet-activating factor acetylhydrolase; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; 3.1.1.47; LDL-PLA(2); LDL-associated phospholipase A2; PAF 2-acylhydrolase; PAF acetylhydrolase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7592717", "class_list": "", "function": "Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (By similarity). At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (By similarity). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position. Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (By similarity). Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells (By similarity). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled pro-inflammatory effects (By similarity). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (By similarity). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1", "type": "external" }, { "id": "2.3.1.149", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.149", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity", "go_cellular_component": "GO:0034364 high-density lipoprotein particle;GO:0034362 low-density lipoprotein particle", "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process;GO:0046469 platelet activating factor metabolic process;GO:0062234 platelet activating factor catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28017-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28019-1", "uniprot_id": [ { "id": "LTBP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28019", "type": "external" } ], "mass": 198410.0, "length": 1842, "protein_name": "Latent-transforming growth factor beta-binding protein 2", "gene_name": "LTBP2", "organism": "Bovine", "refseq_name": "latent-transforming growth factor beta-binding protein 2", "refseq_ac": [ { "id": "NP_776810", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776810", "type": "external" } ], "gene_names_uniprotkb": "LTBP2", "gene_names_refseq": "LTBP2", "protein_names_uniprotkb": "Latent-transforming growth factor beta-binding protein 2; LTBP-2", "protein_names_refseq": "LTBP-2; latent-transforming growth factor beta-binding protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281905)", "pathway_count": 1, "publication_count": 5, "publication_id_list": "10743502;11104663;17581631;19524133;8524260", "class_list": "", "function": "May play an integral structural role in elastic-fiber architectural organization and/or assembly., [UniProtKB, UniProtKB]; These results suggest a novel regulatory mechanism of elastic fiber assembly in which LTBP-2 regulates targeting of DANCE on suitable microfibrils to form elastic fibers., [RefSeq, PubMed]; This is the first study to investigate the expression and localization of fibrillin proteins and latent TGF-beta binding proteins affecting TGFbeta bioavailability in the ovary., [RefSeq, PubMed]", "predicted_glycosites": 10, "predicted_n_glycosites": 9, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 10, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0019838 growth factor binding;GO:0005509 calcium ion binding;GO:0050436 microfibril binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0001527 microfibril;GO:0071953 elastic fiber", "go_biological_process": "GO:0097435 supramolecular fiber organization", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q28019-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28031-1", "uniprot_id": [ { "id": "LPAR1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28031", "type": "external" } ], "mass": 41070.0, "length": 364, "protein_name": "Lysophosphatidic acid receptor 1", "gene_name": "LPAR1", "organism": "Bovine", "refseq_name": "lysophosphatidic acid receptor 1", "refseq_ac": [ { "id": "NP_776472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776472", "type": "external" } ], "gene_names_uniprotkb": "LPAR1; EDG2; LPA1", "gene_names_refseq": "EDG2; LPAR1", "protein_names_uniprotkb": "Lysophosphatidic acid receptor 1; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor Edg-2; Rec1.3", "protein_names_refseq": "LPA receptor 1; LPA-1; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; lysophosphatidic acid receptor 1; lysophosphatidic acid receptor Edg-2; rec1.3", "tax_id": 9913, "disease": "", "pathway": " (bta:281136)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19491366;23522079;9013780", "class_list": "", "function": "Expression is lower in epithelial cells than in stromal cells of the endometrium, [RefSeq, PubMed]; Lysophosphatidic acid stimulates PGE(2) production, cell viability, and intracellular calcium ion mobilization in cultured stromal endometrial cells via Ki16425-sensitive LPA1 receptors., [RefSeq, PubMed]; Receptor for lysophosphatidic acid (LPA). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels. Signaling triggers an increase of cytoplasmic Ca(2+) levels. Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate. Signaling mediates activation of down-stream MAP kinases. Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction. Promotes the activation of Rho and the formation of actin stress fibers. Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1. Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding. Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to LPA. Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation (By similarity). Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070915 lysophosphatidic acid receptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane;GO:0009986 cell surface", "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0010977 negative regulation of neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q28031-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28035-1", "uniprot_id": [ { "id": "GSTA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28035", "type": "external" } ], "mass": 25452.0, "length": 222, "protein_name": "Glutathione S-transferase A1", "gene_name": "GSTA1", "organism": "Bovine", "refseq_name": "glutathione S-transferase A1", "refseq_ac": [ { "id": "NP_001071617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071617", "type": "external" } ], "gene_names_uniprotkb": "GSTA1", "gene_names_refseq": "GSTA1", "protein_names_uniprotkb": "Glutathione S-transferase A1; 1.11.1.-; 13-hydroperoxyoctadecadienoate peroxidase; 2.5.1.18; 5.3.3.-; Androst-5-ene-3,17-dione isomerase; GST class-alpha member 1; Glutathione S-transferase alpha-1", "protein_names_refseq": "13-hydroperoxyoctadecadienoate peroxidase; GST class-alpha member 1; androst-5-ene-3,17-dione isomerase; glutathione S-transferase A1", "tax_id": 9913, "disease": "", "pathway": " (bta:777644)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "10433206", "class_list": "", "function": "Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q3T072", "ec_number_list": [ { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "5.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2", "type": "external" }, { "id": "1.20.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" }, { "id": "4.1.1.84", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.84", "type": "external" }, { "id": "5.3.99.2", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2", "type": "external" }, { "id": "1.11.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12", "type": "external" }, { "id": "1.11.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "5.3.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-", "type": "external" }, { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004769 steroid Delta-isomerase activity;GO:0004601 peroxidase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006805 xenobiotic metabolic process;GO:0006693 prostaglandin metabolic process;GO:1901687 glutathione derivative biosynthetic process;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28035-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28036-1", "uniprot_id": [ { "id": "SL9A1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28036", "type": "external" } ], "mass": 90976.0, "length": 818, "protein_name": "Sodium/hydrogen exchanger 1", "gene_name": "SLC9A1", "organism": "Bovine", "refseq_name": "sodium/hydrogen exchanger 1", "refseq_ac": [ { "id": "NP_777258", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777258", "type": "external" } ], "gene_names_uniprotkb": "SLC9A1; NHE1", "gene_names_refseq": "SLC9A1", "protein_names_uniprotkb": "Sodium/hydrogen exchanger 1; NHE-1; Na(+)/H(+) exchanger 1; Solute carrier family 9 member 1", "protein_names_refseq": "NHE-1; Na(+)/H(+) exchanger 1; sodium proton exchanger; sodium/hydrogen exchanger 1; solute carrier family 9 (sodium/hydrogen exchanger), member 1 (antiporter, Na+/H+, amiloride sensitive); solute carrier family 9 member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:317654)", "pathway_count": 1, "publication_count": 3, "publication_id_list": "19393038;19458287;22407349", "class_list": "", "function": "Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism (By similarity). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival. In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Results support the hypothesis that a blood-brain barrier Na/H exchanger, possibly NHE1 and/or NHE2, is stimulated during ischemia to participate in cerebral edema formation., [RefSeq, PubMed]; This study evaluated the role for NHE-1 in diabetic cataract formation and retinal oxidative stress and apoptosis., [RefSeq, PubMed]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F1MHK2", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity;GO:0005516 calmodulin binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0045121 membrane raft;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0086092 regulation of the force of heart contraction by cardiac conduction;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051259 protein complex oligomerization;GO:0006883 intracellular sodium ion homeostasis;GO:0035994 response to muscle stretch", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q28036-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28041-1", "uniprot_id": [ { "id": "ACVR1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28041", "type": "external" } ], "mass": 57190.0, "length": 509, "protein_name": "Activin receptor type-1", "gene_name": "ACVR1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ACVR1; ACVRLK2", "gene_names_refseq": "", "protein_names_uniprotkb": "Activin receptor type-1; 2.7.11.30; ACTR-I; Activin receptor type I; SKR1; Serine/threonine-protein kinase receptor R1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A ors ACVR2B. Upon binding of ligands such as BMP7 or BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, can activate non-canonical signaling pathways. May promote the expression of HAMP, potentially via its interaction with BMP6 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005025 transforming growth factor beta receptor activity, type I;GO:0016361 activin receptor activity, type I;GO:0046332 SMAD binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048179 activin receptor complex;GO:0070724 BMP receptor complex", "go_biological_process": "GO:0050793 regulation of developmental process;GO:0001701 in utero embryonic development;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0007179 transforming growth factor beta receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q28041-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28107-1", "uniprot_id": [ { "id": "FA5_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28107", "type": "external" } ], "mass": 248983.0, "length": 2211, "protein_name": "Coagulation factor V", "gene_name": "F5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "F5", "gene_names_refseq": "", "protein_names_uniprotkb": "Coagulation factor V; Activated protein C cofactor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:280687)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "15184653;1737753;31061102;7947716", "class_list": "", "function": "Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin., [UniProtKB]", "predicted_glycosites": 22, "predicted_n_glycosites": 22, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 5, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 3, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 5, "total_reported_o_glycosites": 3, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 5, "total_o_glycosites": 3, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 30, "binding_glycan_count": 0, "secondary_ac_list": "Q28108", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031091 platelet alpha granule", "go_biological_process": "GO:0007596 blood coagulation;GO:0008015 blood circulation", "synthesized_glycan_count": 0, "hit_score": 1.4, "record_id": "Q28107-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.1100000010001.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28141-1", "uniprot_id": [ { "id": "DHX9_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28141", "type": "external" } ], "mass": 141944.0, "length": 1287, "protein_name": "ATP-dependent RNA helicase A", "gene_name": "DHX9", "organism": "Bovine", "refseq_name": "ATP-dependent RNA helicase A", "refseq_ac": [ { "id": "NP_776461", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776461", "type": "external" } ], "gene_names_uniprotkb": "DHX9; DDX9; NDH2", "gene_names_refseq": "DDX9; DHX9; RHA", "protein_names_uniprotkb": "ATP-dependent RNA helicase A; 3.6.4.13; DEAH box protein 9; NDH II; Nuclear DNA helicase II", "protein_names_refseq": "ATP-dependent RNA helicase A; DEAH (Asp-Glu-Ala-His) box helicase 9; DEAH (Asp-Glu-Ala-His) box polypeptide 9; DEAH box protein 9; DEAH-box helicase 9; NDH II; nuclear DNA helicase II", "tax_id": 9913, "disease": "", "pathway": " (bta:281115); (R-BTA-1810476); (R-BTA-3134963); (R-BTA-72163); (R-BTA-9770562); (R-BTA-9833482)", "pathway_count": 6, "publication_count": 3, "publication_id_list": "24606677;7511411;7608213", "class_list": "", "function": "Demethylated RHA bound JMJD6 monomer during foot-and-mouth disease virus infection., [RefSeq, PubMed]; Multifunctional ATP-dependent nucleic acid helicase that unwinds DNA and RNA in a 3' to 5' direction and that plays important roles in many processes, such as DNA replication, transcriptional activation, post-transcriptional RNA regulation, mRNA translation and RNA-mediated gene silencing (PubMed:7511411). Requires a 3'-single-stranded tail as entry site for acid nuclei unwinding activities as well as the binding and hydrolyzing of any of the four ribo- or deoxyribo-nucleotide triphosphates (NTPs) (PubMed:7511411). Unwinds numerous nucleic acid substrates such as double-stranded (ds) DNA and RNA, DNA:RNA hybrids, DNA and RNA forks composed of either partially complementary DNA duplexes or DNA:RNA hybrids, respectively, and also DNA and RNA displacement loops (D- and R-loops), triplex-helical DNA (H-DNA) structure and DNA and RNA-based G-quadruplexes (PubMed:7511411). Binds dsDNA, single-stranded DNA (ssDNA), dsRNA, ssRNA and poly(A)-containing RNA (PubMed:7511411). Also binds to circular dsDNA or dsRNA of either linear and/or circular forms and stimulates the relaxation of supercoiled DNAs catalyzed by topoisomerase TOP2A. Plays a role in DNA replication at origins of replication and cell cycle progression. Plays a role as a transcriptional coactivator acting as a bridging factor between polymerase II holoenzyme and transcription factors or cofactors, such as BRCA1, CREBBP, RELA and SMN1. Binds to the CDKN2A promoter. Plays several roles in post-transcriptional regulation of gene expression. In cooperation with NUP98, promotes pre-mRNA alternative splicing activities of a subset of genes. As component of a large PER complex, is involved in the negative regulation of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms. Also acts as a nuclear resolvase that is able to bind and neutralize harmful massive secondary double-stranded RNA structures formed by inverted-repeat Alu retrotransposon elements that are inserted and transcribed as parts of genes during the process of gene transposition. Involved in the positive regulation of nuclear export of constitutive transport element (CTE)-containing unspliced mRNA. Component of the coding region determinant (CRD)-mediated complex that promotes cytoplasmic MYC mRNA stability. Plays a role in mRNA translation. Positively regulates translation of selected mRNAs through its binding to post-transcriptional control element (PCE) in the 5'-untranslated region (UTR). Involved with LARP6 in the translation stimulation of type I collagen mRNAs for CO1A1 and CO1A2 through binding of a specific stem-loop structure in their 5'-UTRs. Stimulates LIN28A-dependent mRNA translation probably by facilitating ribonucleoprotein remodeling during the process of translation. Also plays a role as a small interfering (siRNA)-loading factor involved in the RNA-induced silencing complex (RISC) loading complex (RLC) assembly, and hence functions in the RISC-mediated gene silencing process. Binds preferentially to short double-stranded RNA, such as those produced during rotavirus intestinal infection. This interaction may mediate NLRP9 inflammasome activation and trigger inflammatory response, including IL18 release and pyroptosis. Finally, mediates the attachment of heterogeneous nuclear ribonucleoproteins (hnRNPs) to actin filaments in the nucleus., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.7.7.52", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52", "type": "external" }, { "id": "2.7.7.19", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.1.78", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.78", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.27.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003688 DNA replication origin binding;GO:0043138 3'-5' DNA helicase activity;GO:0045142 triplex DNA binding;GO:0061676 importin-alpha family protein binding;GO:1905172 RISC complex binding", "go_cellular_component": "GO:0005726 perichromatin fibrils;GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0071360 cellular response to exogenous dsRNA;GO:0032727 positive regulation of interferon-alpha production;GO:0046833 positive regulation of RNA export from nucleus;GO:0060760 positive regulation of response to cytokine stimulus;GO:0070922 RISC complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q28141-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28142-1", "uniprot_id": [ { "id": "NRX1B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28142", "type": "external" } ], "mass": 50084.0, "length": 467, "protein_name": "Neurexin-1-beta", "gene_name": "NRXN1", "organism": "Bovine", "refseq_name": "neurexin-1 isoform 2", "refseq_ac": [ { "id": "NP_001103275", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103275", "type": "external" } ], "gene_names_uniprotkb": "NRXN1", "gene_names_refseq": "NRXN1", "protein_names_uniprotkb": "Neurexin-1-beta; Neurexin I-beta", "protein_names_refseq": "neurexin-1 isoform 2", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 5, "publication_id_list": "16772286;21552542;21620716;21620717;8163501", "class_list": "", "function": "Crystallographic analysis of the second LNS/LG domain from neurexin 1alpha, [RefSeq, PubMed]; Neuronal cell surface protein involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins (By similarity). Plays a role in formation of synaptic junctions (By similarity). Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Structural basis for neuroligin binding Publication Status: Online-Only, [RefSeq, PubMed]; The crystal structure of the alpha-neurexin-1 extracellular region reveals a hinge point for mediating synaptic adhesion and function, [RefSeq, PubMed]; The structure of neurexin 1alpha reveals features promoting a role as synaptic organizer, [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "Q28142-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28143-1", "uniprot_id": [ { "id": "NRX3B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28143", "type": "external" } ], "mass": 50244.0, "length": 456, "protein_name": "Neurexin-3-beta", "gene_name": "NRXN3", "organism": "Bovine", "refseq_name": "neurexin 3 isoform X12", "refseq_ac": [ { "id": "XP_024853581", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024853581", "type": "external" } ], "gene_names_uniprotkb": "NRXN3", "gene_names_refseq": "NRXN3; NRXNIII", "protein_names_uniprotkb": "Neurexin-3-beta; Neurexin III-beta", "protein_names_refseq": "neurexin 3 isoform X12", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "8163501", "class_list": "", "function": "Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "Q28144", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28143-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28172-1", "uniprot_id": [ { "id": "PRLR_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28172", "type": "external" } ], "mass": 65153.0, "length": 581, "protein_name": "Prolactin receptor", "gene_name": "PRLR", "organism": "Bovine", "refseq_name": "prolactin receptor long isoform precursor", "refseq_ac": [ { "id": "NP_001034815", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034815", "type": "external" } ], "gene_names_uniprotkb": "PRLR", "gene_names_refseq": "PRLR; SPRLR", "protein_names_uniprotkb": "Prolactin receptor; PRL-R", "protein_names_refseq": "PRL-R; prolactin receptor long form; prolactin receptor long isoform precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281422)", "pathway_count": 1, "publication_count": 10, "publication_id_list": "12403840;1338725;17675186;20349144;25533929;29926362;34642995;7738463;9231767;9343303", "class_list": "", "function": "Inheritance of the SLICK1 allele of PRLR in cattle., [RefSeq, PubMed]; Multiple internalization motifs differentially used by this protein's isoforms mediate similar endocytic pathways., [RefSeq, PubMed]; Rs135164815 (P = 0.033) and rs136247583 (P = 0.049) were associated with fertility in hot-humid climate, [RefSeq, PubMed]; The presence and localization of prolactin receptor are consistent with expression data reported for other species, and the presence of PIP and prolactin in seminal fluid is consistent with data generated in humans., [RefSeq, PubMed]; This is a receptor for the anterior pituitary hormone prolactin., [UniProtKB]; This study revealed for the first time that the PRLR gene is a promising candidate gene that affects growth traits in cattle., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "O18880;O46591", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0017046 peptide hormone binding;GO:0019955 cytokine binding;GO:0004925 prolactin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0019221 cytokine-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 1.1, "record_id": "Q28172-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28178-1", "uniprot_id": [ { "id": "TSP1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28178", "type": "external" } ], "mass": 129534.0, "length": 1170, "protein_name": "Thrombospondin-1", "gene_name": "THBS1", "organism": "Bovine", "refseq_name": "thrombospondin-1 precursor", "refseq_ac": [ { "id": "NP_776621", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776621", "type": "external" } ], "gene_names_uniprotkb": "THBS1; TSP-1; TSP1", "gene_names_refseq": "THBS1; THBS", "protein_names_uniprotkb": "Thrombospondin-1; Glycoprotein G", "protein_names_refseq": "glycoprotein G; thrombospondin-1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:281530)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "12761883;12808019;15371459;19887196;25061096;27396384;29228113;9507054", "class_list": "", "function": "Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Multifunctional, involved in inflammation, angiogenesis, wound healing, reactive oxygen species (ROS) signaling, nitrous oxide (NO) signaling, apoptosis, senescence, aging, cellular self-renewal, stemness, and cardiovascular and metabolic homeostasis. Negatively modulates dendritic cell activation and cytokine release, as part of an autocrine feedback loop, contributing to the resolution of inflammation and immune homeostasis. Ligand for receptor CD47 (By similarity). Modulates nitrous oxide (NO) signaling via CD47, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays a role in endothelial cell senescence, acting via CD47, by increasing the abundance and activation of NADPH oxidase NOX1, and so generating excess ROS (By similarity). Inhibits stem cell self-renewal, acting via CD47 signaling, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4. Negatively modulates wound healing, acting via CD47 (By similarity). Ligand for receptor CD36 (By similarity). Involved in inducing apoptosis in podocytes in response to elevated free fatty acids, acting via CD36 (By similarity). Plays a role in suppressing angiogenesis, acting, depending on context, via CD36 or CD47. Promotes cellular senescence in a TP53-CDKN1A-RB1 signaling-dependent manner. Ligand for immunoglobulin-like cell surface receptor SIRPA. Involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production, acting via interaction with SIRPA (By similarity). Plays a role in metabolic dysfunction in diet-induced obesity, perhaps acting by exacerbating adipose inflammatory activity; its effects may be mediated, at least in part, through enhanced adipocyte proliferation. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors (By similarity). May be involved in age-related conditions, including metabolic dysregulation, during normal aging (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data suggest THBS1 expression predominates in luteal endothelial cells; THBS2 expression predominates in luteinized granulosa cells. Luteinization down-regulates expression of THBS1/THBS2, up-regulates expression of FGF2 (fibroblast growth factor 2)., [RefSeq, PubMed]; Role in inducing vascular smooth muscle cell chemotaxis, [RefSeq, PubMed]; Temporal expression and localization pattern of the thrombospondins and their specific receptors in the antral follicles and corpora lutea during the different physiological phases of the estrous cycle and induced luteolysis appear to be compatible with their inhibitory role in the control of ovarian angiogenesis, [RefSeq, PubMed]; The novel finding that TSP-1-induced migration is dependent on the CD44 receptor links 2 pathways thought to be disparate (ie, TSP-1 and HyA)., [RefSeq, PubMed]; These data support the contention that FGF2 and TGFB1 modulate THBS1 via miR-221., [RefSeq, PubMed]; Thrombospondin has a role in inducing RhoA inactivation through FAK-dependent signaling to stimulate focal adhesion disassembly, [RefSeq, PubMed]; Thrombospondin has a role in regulating the migratory phenotype of endothelial cells and fibroblasts, [RefSeq, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "Q28179", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005509 calcium ion binding;GO:0050840 extracellular matrix binding;GO:0001968 fibronectin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface;GO:0031012 extracellular matrix;GO:0016529 sarcoplasmic reticulum", "go_biological_process": "GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0030335 positive regulation of cell migration;GO:0048514 blood vessel morphogenesis;GO:0001937 negative regulation of endothelial cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q28178-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28199-1", "uniprot_id": [ { "id": "CD5R1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28199", "type": "external" } ], "mass": 34088.0, "length": 307, "protein_name": "Cyclin-dependent kinase 5 activator 1", "gene_name": "CDK5R1", "organism": "Bovine", "refseq_name": "cyclin-dependent kinase 5 activator 1 precursor", "refseq_ac": [ { "id": "NP_776937", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776937", "type": "external" } ], "gene_names_uniprotkb": "CDK5R1; CDK5R; NCK5A", "gene_names_refseq": "CDK5R1; P25/P35", "protein_names_uniprotkb": "Cyclin-dependent kinase 5 activator 1; CDK5 activator 1; Cyclin-dependent kinase 5 regulatory subunit 1; TPKII regulatory subunit; Tau protein kinase II 23 kDa subunit; p23", "protein_names_refseq": "CDK5 activator 1; TPKII regulatory subunit; cyclin-dependent kinase 5 activator 1 precursor; cyclin-dependent kinase 5 activator 1; cyclin-dependent kinase 5, regulatory subunit 1 (p35); p23; tau protein kinase II 23 kDa subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:282173); (R-BTA-399956); (R-BTA-6804756)", "pathway_count": 3, "publication_count": 3, "publication_id_list": "7957957;8090222;8143878", "class_list": "", "function": "p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0II69;Q28865;Q29462", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding;GO:0019901 protein kinase binding;GO:0051015 actin filament binding;GO:0005509 calcium ion binding;GO:0045296 cadherin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0014069 postsynaptic density", "go_biological_process": "GO:0021799 cerebral cortex radially oriented cell migration;GO:0009792 embryo development ending in birth or egg hatching;GO:0007213 G protein-coupled acetylcholine receptor signaling pathway;GO:0031175 neuron projection development;GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q28199-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28824-1", "uniprot_id": [ { "id": "MYLK_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28824", "type": "external" } ], "mass": 128825.0, "length": 1176, "protein_name": "Myosin light chain kinase, smooth muscle", "gene_name": "MYLK", "organism": "Bovine", "refseq_name": "myosin light chain kinase, smooth muscle isoform 1", "refseq_ac": [ { "id": "NP_788809", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788809", "type": "external" } ], "gene_names_uniprotkb": "MYLK", "gene_names_refseq": "MLCK; MYLK; smMLCK", "protein_names_uniprotkb": "Myosin light chain kinase, smooth muscle; 2.7.11.18; MLCK; Telokin; smMLCK", "protein_names_refseq": "myosin light chain kinase, smooth muscle isoform 1; myosin light chain kinase, smooth muscle; myosin, light polypeptide kinase; telokin", "tax_id": 9913, "disease": "", "pathway": " (bta:338037); (R-BTA-445355); (R-BTA-5627123)", "pathway_count": 3, "publication_count": 4, "publication_id_list": "1284247;1534225;17479229;9405419", "class_list": "", "function": "Calcium/calmodulin-dependent myosin light chain kinase implicated in smooth muscle contraction via phosphorylation of myosin light chains (MLC). Also regulates actin-myosin interaction through a non-kinase activity. Phosphorylates PTK2B/PYK2 and myosin light-chains. Involved in the inflammatory response (e.g. apoptosis, vascular permeability, leukocyte diapedesis), cell motility and morphology, airway hyperreactivity and other activities relevant to asthma. Required for tonic airway smooth muscle contraction that is necessary for physiological and asthmatic airway resistance. Necessary for gastrointestinal motility. Implicated in the regulation of endothelial as well as vascular permeability, probably via the regulation of cytoskeletal rearrangements. In the nervous system it has been shown to control the growth initiation of astrocytic processes in culture and to participate in transmitter release at synapses formed between cultured sympathetic ganglion cells. Critical participant in signaling sequences that result in fibroblast apoptosis. Plays a role in the regulation of epithelial cell survival. Required for epithelial wound healing, especially during actomyosin ring contraction during purse-string wound closure. Mediates RhoA-dependent membrane blebbing. Triggers TRPC5 channel activity in a calcium-dependent signaling, by inducing its subcellular localization at the plasma membrane. Promotes cell migration (including tumor cells) and tumor metastasis. PTK2B/PYK2 activation by phosphorylation mediates ITGB2 activation and is thus essential to trigger neutrophil transmigration during acute lung injury (ALI). May regulate optic nerve head astrocyte migration. Probably involved in mitotic cytoskeletal regulation. Regulates tight junction probably by modulating ZO-1 exchange in the perijunctional actomyosin ring. Mediates burn-induced microvascular barrier injury; triggers endothelial contraction in the development of microvascular hyperpermeability by phosphorylating MLC. Essential for intestinal barrier dysfunction. Mediates Giardia spp.-mediated reduced epithelial barrier function during giardiasis intestinal infection via reorganization of cytoskeletal F-actin and tight junctional ZO-1. Necessary for hypotonicity-induced Ca(2+) entry and subsequent activation of volume-sensitive organic osmolyte/anion channels (VSOAC) in cervical cancer cells (By similarity)., [UniProtKB, PubMed]; Histamine induces myosin light chain (MLC)phosphorylation via MYLK, suggesting regulatory role for MLC in controlling corneal epithelial permeability., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.18", "type": "external" } ], "go_molecular_function": "GO:0003779 actin binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004687 myosin light chain kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030027 lamellipodium;GO:0001725 stress fiber;GO:0032154 cleavage furrow", "go_biological_process": "GO:0014820 tonic smooth muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q28824-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q28901-1", "uniprot_id": [ { "id": "F263_BOVIN", "url": "https://www.uniprot.org/uniprot/Q28901", "type": "external" } ], "mass": 53584.0, "length": 463, "protein_name": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3", "gene_name": "PFKFB3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PFKFB3", "gene_names_refseq": "", "protein_names_uniprotkb": "6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; PFK/FBPase 3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "7733968", "class_list": "", "function": "Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.105", "type": "external" }, { "id": "3.1.3.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.46", "type": "external" } ], "go_molecular_function": "GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity;GO:0005524 ATP binding;GO:0003873 6-phosphofructo-2-kinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006000 fructose metabolic process;GO:0006003 fructose 2,6-bisphosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q28901-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29423-1", "uniprot_id": [ { "id": "CD44_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29423", "type": "external" } ], "mass": 40002.0, "length": 366, "protein_name": "CD44 antigen", "gene_name": "CD44", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CD44", "gene_names_refseq": "", "protein_names_uniprotkb": "CD44 antigen; ECMR-III; Extracellular matrix receptor III; GP90 lymphocyte homing/adhesion receptor; HUTCH-I; Hermes antigen; Hyaluronate receptor; PGP-1; PGP-I; Phagocytic glycoprotein 1; Phagocytic glycoprotein I", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "1922105", "class_list": "", "function": "Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. Upon interaction with LGALS9 ligand, activates downstream signaling components including LCK, ERK and MAPK to promotes NK cell activation., [UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005540 hyaluronic acid binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0048731 system development;GO:0006954 inflammatory response;GO:0007155 cell adhesion;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0042981 regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q29423-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29437-1", "uniprot_id": [ { "id": "AOCX_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29437", "type": "external" } ], "mass": 84757.0, "length": 762, "protein_name": "Primary amine oxidase, liver isozyme", "gene_name": "", "organism": "Bovine", "refseq_name": "primary amine oxidase, liver isozyme precursor", "refseq_ac": [ { "id": "NP_001124236", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124236", "type": "external" } ], "gene_names_uniprotkb": "", "gene_names_refseq": "BSAO; SAO", "protein_names_uniprotkb": "Primary amine oxidase, liver isozyme; 1.4.3.21; Amine oxidase [copper-containing]; Copper amine oxidase; SAO; Serum amine oxidase", "protein_names_refseq": "copper amine oxidase; precursor; primary amine oxidase, liver isozyme precursor; primary amine oxidase, liver isozyme; serum amine oxidase", "tax_id": 9913, "disease": "", "pathway": " (bta:789307)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1457410;15701511;27295021;8144587", "class_list": "", "function": "Homodimeric and monomeric SMOXs are catalytically active, as revealed after gel staining for enzymatic activity. An engineered SMOX mutant deprived of all but two cysteine residues was prepared and characterized experimentally, resulting in a monomeric species. High-sensitivity differential scanning calorimetry of SMOX was compared with that of bovine serum amine oxidase, to analyse their thermal stability., [RefSeq, PubMed]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 3, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 3, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 3, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-", "type": "external" }, { "id": "1.4.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.21", "type": "external" }, { "id": "1.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.4", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005507 copper ion binding;GO:0008131 primary methylamine oxidase activity;GO:0048038 quinone binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0009308 amine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.8, "record_id": "Q29437-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.1000000001000.101.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29444-1", "uniprot_id": [ { "id": "MANBA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29444", "type": "external" } ], "mass": 101176.0, "length": 879, "protein_name": "Beta-mannosidase", "gene_name": "MANBA", "organism": "Bovine", "refseq_name": "beta-mannosidase precursor", "refseq_ac": [ { "id": "NP_776812", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776812", "type": "external" } ], "gene_names_uniprotkb": "MANBA", "gene_names_refseq": "MANBA", "protein_names_uniprotkb": "Beta-mannosidase; 3.2.1.25; Lysosomal beta A mannosidase; Mannanase; Mannase", "protein_names_refseq": "beta-mannosidase precursor; beta-mannosidase; lysosomal beta A mannosidase; mannanase; mannase; mannosidase, beta A, lysosomal", "tax_id": 9913, "disease": "", "pathway": " (bta:281909)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "7876128;8424779", "class_list": "glycogene;glycosylhydrolase", "function": "Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides., [UniProtKB, PubMed]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004567 beta-mannosidase activity", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006516 glycoprotein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q29444-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29449-1", "uniprot_id": [ { "id": "AT8A1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29449", "type": "external" } ], "mass": 130026.0, "length": 1149, "protein_name": "Probable phospholipid-transporting ATPase IA", "gene_name": "ATP8A1", "organism": "Bovine", "refseq_name": "probable phospholipid-transporting ATPase IA", "refseq_ac": [ { "id": "NP_777263", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777263", "type": "external" } ], "gene_names_uniprotkb": "ATP8A1", "gene_names_refseq": "ATP8A1", "protein_names_uniprotkb": "Probable phospholipid-transporting ATPase IA; 7.6.2.1; ATPase class I type 8A member 1; Chromaffin granule ATPase II", "protein_names_refseq": "ATPase class I type 8A member 1; chromaffin granule ATPase II; probable phospholipid-transporting ATPase IA", "tax_id": 9913, "disease": "", "pathway": " (bta:317692)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "30760526;8633245", "class_list": "", "function": "Asparagine 905 of the mammalian phospholipid flippase ATP8A2 is essential for lipid substrate-induced activation of ATP8A2 dephosphorylation., [RefSeq, PubMed]; Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (By similarity). Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. In vitro, its ATPase activity is selectively and stereospecifically stimulated by phosphatidylserine (PS) (By similarity). The flippase complex ATP8A1:TMEM30A seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the cell membrane (By similarity). Acts as aminophospholipid translocase at the cell membrane in neuronal cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0090556 phosphatidylserine floppase activity;GO:0140326 ATPase-coupled intramembrane lipid transporter activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0031090 organelle membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0045332 phospholipid translocation;GO:0140331 aminophospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q29449-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29450-1", "uniprot_id": [ { "id": "ADCY7_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29450", "type": "external" } ], "mass": 120820.0, "length": 1078, "protein_name": "Adenylate cyclase type 7", "gene_name": "ADCY7", "organism": "Bovine", "refseq_name": "adenylate cyclase type 7", "refseq_ac": [ { "id": "NP_776655", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_776655", "type": "external" } ], "gene_names_uniprotkb": "ADCY7", "gene_names_refseq": "ADCY7", "protein_names_uniprotkb": "Adenylate cyclase type 7; 2.7.7.85; 4.6.1.1; ATP pyrophosphate-lyase 7; Adenylate cyclase type VII; Adenylyl cyclase 7; Cyclic di-AMP synthase ADCY7", "protein_names_refseq": "ATP pyrophosphate-lyase 7; adenylate cyclase type 7; adenylate cyclase type VII; adenylyl cyclase 7; cyclic di-AMP synthase ADCY7", "tax_id": 9913, "disease": "", "pathway": " (bta:281603)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "8557110", "class_list": "", "function": "Adenylate cyclase that mediates formation of both cyclic AMP (cAMP) and cyclic di-AMP (c-di-AMP) (By similarity). Acts as a key mediator of G protein-coupled receptor signaling by catalyzing the formation of cAMP downstream of G protein-coupled receptors. Functions in G protein-coupled receptor signaling cascades activated by thrombin, sphingosine 1-phosphate, dopamine and anaphylatoxin C5a (By similarity). Mediates regulation of cAMP synthesis through synergistic action of the G alpha protein G(s) (GNAS) with G(13) (GNA13). Also involved in inflammation by acting as a diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into c-di-AMP. Following activation by TLR9, mediates formation of c-di-AMP, which directly activates NLRP3, thereby promoting assembly and maturation of the NLRP3 inflammasome. It is also required for the optimal functions of B- and T cells during adaptive immune responses by regulating cAMP synthesis in both B- and T-cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "O02856", "ec_number_list": [ { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106408 diadenylate cyclase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0071361 cellular response to ethanol;GO:1900016 negative regulation of cytokine production involved in inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q29450-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RH3-1", "uniprot_id": [ { "id": "NUD12_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RH3", "type": "external" } ], "mass": 50119.0, "length": 444, "protein_name": "NAD-capped RNA hydrolase NUDT12", "gene_name": "NUDT12", "organism": "Bovine", "refseq_name": "NAD-capped RNA hydrolase NUDT12", "refseq_ac": [ { "id": "NP_001040073", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040073", "type": "external" } ], "gene_names_uniprotkb": "NUDT12", "gene_names_refseq": "NUDT12", "protein_names_uniprotkb": "NAD-capped RNA hydrolase NUDT12; 3.6.1.-; 3.6.1.22; DeNADding enzyme NUDT12; NADH pyrophosphatase NUDT12; Nucleoside diphosphate-linked moiety X motif 12; Nudix motif 12", "protein_names_refseq": "NAD-capped RNA hydrolase NUDT12; deNADding enzyme NUDT12; nucleoside diphosphate-linked moiety X motif 12; nudix (nucleoside diphosphate linked moiety X)-type motif 12; nudix motif 12; nudix-type motif 12; peroxisomal NADH pyrophosphatase NUDT12", "tax_id": 9913, "disease": "", "pathway": " (bta:617720); (R-BTA-196807)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some RNAs; in contrast to the canonical N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay. Preferentially acts on NAD-capped transcripts in response to nutrient stress (By similarity). Also acts on free nicotinamide adenine dinucleotide molecules: hydrolyzes NAD(H) into NMN(H) and AMP, and NADPH into NMNH and 2',5'-ADP. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle (By similarity). Regulates the levels of circadian clock components PER1, PER2, PER3 and CRY2 in the liver (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.22", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.7.7.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.2", "type": "external" }, { "id": "3.6.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.18", "type": "external" } ], "go_molecular_function": "GO:0000210 NAD+ diphosphatase activity;GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding;GO:0035529 NADH pyrophosphatase activity;GO:0110153 RNA NAD-cap (NMN-forming) hydrolase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0006402 mRNA catabolic process;GO:0032922 circadian regulation of gene expression;GO:0006742 NADP+ catabolic process;GO:0110155 NAD-cap decapping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RH3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RP8-1", "uniprot_id": [ { "id": "KMT5B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RP8", "type": "external" } ], "mass": 44552.0, "length": 393, "protein_name": "Histone-lysine N-methyltransferase KMT5B", "gene_name": "KMT5B", "organism": "Bovine", "refseq_name": "histone-lysine N-methyltransferase KMT5B", "refseq_ac": [ { "id": "NP_001070019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070019", "type": "external" } ], "gene_names_uniprotkb": "KMT5B; SUV420H1", "gene_names_refseq": "KMT5B; SUV420H1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase KMT5B; 2.1.1.361; 2.1.1.362; Lysine-specific methyltransferase 5B; Su(var)4-20 homolog 1; Suppressor of variegation 4-20 homolog 1; Suv4-20h1; [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B", "protein_names_refseq": "[histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B; [histone H4]-lysine20 N-methyltransferase KMT5B; histone-lysine N-methyltransferase KMT5B; histone-lysine N-methyltransferase SUV420H1; lysine-specific methyltransferase 5B; su(var)4-20 homolog 1; suppressor of variegation 4-20 homolog 1; suv4-20h1", "tax_id": 9913, "disease": "", "pathway": " (bta:767828)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Plays a role in myogenesis by regulating the expression of target genes, such as EID3. Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046872 metal ion binding;GO:0042054 histone methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding;GO:0042799 histone H4K20 methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome", "go_biological_process": "GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0007517 muscle organ development;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RP8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29RT0-1", "uniprot_id": [ { "id": "RBMX_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29RT0", "type": "external" } ], "mass": 42369.0, "length": 396, "protein_name": "RNA-binding motif protein, X chromosome", "gene_name": "RBMX", "organism": "Bovine", "refseq_name": "RNA-binding motif protein, X chromosome", "refseq_ac": [ { "id": "NP_001040075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001040075", "type": "external" } ], "gene_names_uniprotkb": "RBMX; HNRPG", "gene_names_refseq": "HNRNPG-T; RBMXL2; RBMX", "protein_names_uniprotkb": "RNA-binding motif protein, X chromosome; Heterogeneous nuclear ribonucleoprotein G; hnRNP G", "protein_names_refseq": "RNA binding motif protein, X-linked like 2; RNA-binding motif protein, X chromosome; heterogeneous nuclear ribonucleoprotein G; hnRNP G; testes-specific heterogenous nuclear ribonucleoprotein G-T", "tax_id": 9913, "disease": "", "pathway": " (bta:617969)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0070062 extracellular exosome;GO:0005681 spliceosomal complex;GO:0000791 euchromatin;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0048026 positive regulation of mRNA splicing, via spliceosome;GO:0006509 membrane protein ectodomain proteolysis;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051260 protein homooligomerization;GO:0048025 negative regulation of mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q29RT0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q29W20-1", "uniprot_id": [ { "id": "EGR1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q29W20", "type": "external" } ], "mass": 57115.0, "length": 540, "protein_name": "Early growth response protein 1", "gene_name": "EGR1", "organism": "Bovine", "refseq_name": "early growth response protein 1", "refseq_ac": [ { "id": "NP_001039340", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039340", "type": "external" } ], "gene_names_uniprotkb": "EGR1", "gene_names_refseq": "EGR1", "protein_names_uniprotkb": "Early growth response protein 1; EGR-1", "protein_names_refseq": "EGR-1; early growth response protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:407125)", "pathway_count": 1, "publication_count": 8, "publication_id_list": "15475598;17032742;22140445;28256014;28733346;29723542;31176405;31245944", "class_list": "", "function": "Chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling., [RefSeq, PubMed]; During the differentiation of bovine skeletal muscle satellite cells, the transcriptional level of EGR1 gene is increased, and some EGR1 proteins are transferred into the nucleus., [RefSeq, PubMed]; EGR-1's expression prior to ovulation and its stimulating effect on the expression of genes known to be involved in prostaglandin biosynthesis pathway, suggest its potential involvement in the regulation of preovulatory events in cattle., [RefSeq, PubMed]; EGR1 can promote skeletal muscle satellite cell differentiation through positive regulation of MyoG gene expression., [RefSeq, PubMed]; EGR1 is a major upstream component of FGF signaling in theca cells and that it directs cell fate toward proliferation., [RefSeq, PubMed]; Suggest that EGR1 is likely an upstream component of FGF signaling in granulosa cells., [RefSeq, PubMed]; The authors conclude that Egr-1 protein expression is very sensitive to upregulation by hypoxia in pulmonary artery adventitial fibroblasts and that it plays an important role in the autonomous growth phenotype induced by hypoxia in these cells., [RefSeq, PubMed]; This is the first study to reveal that bta-miR-2361 as a novel host factor regulates Bovine herpesvirus 1 replication via directly targeting the EGR1 gene., [RefSeq, PubMed]; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity). Regulates the amplitude of the expression rhythms of clock genes: BMAL1, PER2 and NR1D1 in the liver via the activation of PER1 (clock repressor) transcription. Regulates the rhythmic expression of core-clock gene BMAL1 in the suprachiasmatic nucleus (SCN) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0060086 circadian temperature homeostasis;GO:0002931 response to ischemia;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q29W20-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ23-1", "uniprot_id": [ { "id": "MLP3A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ23", "type": "external" } ], "mass": 14286.0, "length": 121, "protein_name": "Microtubule-associated protein 1 light chain 3 alpha", "gene_name": "MAP1LC3A", "organism": "Bovine", "refseq_name": "microtubule-associated protein 1 light chain 3 alpha", "refseq_ac": [ { "id": "NP_001039640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039640", "type": "external" } ], "gene_names_uniprotkb": "MAP1LC3A", "gene_names_refseq": "MAP1LC3A", "protein_names_uniprotkb": "Microtubule-associated protein 1 light chain 3 alpha; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; Microtubule-associated proteins 1A/1B light chain 3A", "protein_names_refseq": "MAP1 light chain 3-like protein 1; MAP1A/1B light chain 3 A; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; autophagy-related protein LC3 A; autophagy-related ubiquitin-like modifier LC3 A; microtubule-associated protein 1 light chain 3 alpha; microtubule-associated proteins 1A/1B light chain 3A", "tax_id": 9913, "disease": "", "pathway": " (bta:514547); (R-BTA-1632852); (R-BTA-5205685); (R-BTA-8934903)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0008017 microtubule binding;GO:0031625 ubiquitin protein ligase binding;GO:0008429 phosphatidylethanolamine binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0005829 cytosol;GO:0005874 microtubule;GO:0012505 endomembrane system;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0000045 autophagosome assembly;GO:0000423 mitophagy;GO:0006995 cellular response to nitrogen starvation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ23-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ27-1", "uniprot_id": [ { "id": "MYC_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ27", "type": "external" } ], "mass": 48390.0, "length": 439, "protein_name": "Myc proto-oncogene protein", "gene_name": "MYC", "organism": "Bovine", "refseq_name": "myc proto-oncogene protein", "refseq_ac": [ { "id": "NP_001039539", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039539", "type": "external" } ], "gene_names_uniprotkb": "MYC", "gene_names_refseq": "CMYC; MYC", "protein_names_uniprotkb": "Myc proto-oncogene protein; Proto-oncogene c-Myc; Transcription factor p64", "protein_names_refseq": "avian myelocytomatosis viral (v-myc) oncogene homolog; c-Myc; myc proto-oncogene protein; proto-oncogene c-Myc; transcription factor p64; v-myc avian myelocytomatosis viral oncogene homolog; v-myc myelocytomatosis viral oncogene homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:511077); (R-BTA-5689880); (R-BTA-8866911)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "17431641;32632086", "class_list": "", "function": "Evolutionary-driven C-MYC gene expression in mammalian fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; Ouabain-induced proliferation might be attributed, at least in part, to decrease of intracellular free calcium and increase of c-myc mRNA expression, and that may be directly or indirectly involved in regulation of blood pressure., [RefSeq, PubMed]; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). Positively regulates transcription of HNRNPA1, HNRNPA2 and PTBP1 which in turn regulate splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 14, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0044877 protein-containing complex binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005819 spindle", "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2HJ27-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJ40-1", "uniprot_id": [ { "id": "BACE1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJ40", "type": "external" } ], "mass": 55725.0, "length": 501, "protein_name": "Beta-secretase 1", "gene_name": "BACE1", "organism": "Bovine", "refseq_name": "beta-secretase 1 precursor", "refseq_ac": [ { "id": "NP_001039996", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039996", "type": "external" } ], "gene_names_uniprotkb": "BACE1", "gene_names_refseq": "BACE1", "protein_names_uniprotkb": "Beta-secretase 1; 3.4.23.46; Beta-site APP cleaving enzyme 1; Beta-site amyloid precursor protein cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2", "protein_names_refseq": "beta-secretase 1 precursor; beta-site APP-cleaving enzyme 1; beta-site amyloid precursor protein cleaving enzyme 1; memapsin-2; membrane-associated aspartic protease 2", "tax_id": 9913, "disease": "", "pathway": " (bta:614333)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase (By similarity). Cleaves CHL1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004190 aspartic-type endopeptidase activity;GO:0001540 amyloid-beta binding;GO:0120283 protein serine/threonine kinase binding", "go_cellular_component": "GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0006509 membrane protein ectodomain proteolysis;GO:0016485 protein processing;GO:0050435 amyloid-beta metabolic process;GO:0043525 positive regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJ40-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJA4-1", "uniprot_id": [ { "id": "PAR2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJA4", "type": "external" } ], "mass": 43766.0, "length": 395, "protein_name": "Proteinase-activated receptor 2", "gene_name": "F2RL1", "organism": "Bovine", "refseq_name": "proteinase-activated receptor 2 precursor", "refseq_ac": [ { "id": "NP_001039748", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039748", "type": "external" } ], "gene_names_uniprotkb": "F2RL1; PAR2", "gene_names_refseq": "F2RL1; PAR2", "protein_names_uniprotkb": "Proteinase-activated receptor 2; Coagulation factor II receptor-like 1; PAR-2; Thrombin receptor-like 1", "protein_names_refseq": "PAR-2; coagulation factor II (thrombin) receptor-like 1; coagulation factor II receptor-like 1; protease-activated receptor 2; proteinase-activated receptor 2 precursor; proteinase-activated receptor 2; thrombin receptor-like 1", "tax_id": 9913, "disease": "", "pathway": " (bta:526525)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19064814", "class_list": "", "function": "PAR1 and PAR2 regulate endothelial NO synthase phosphorylation and activity through G(12/13) and G(q), delineating the signaling pathways by which the proteases act on protease-activated receptors to modulate endothelial functions., [RefSeq, PubMed]; Receptor for trypsin and trypsin-like enzymes coupled to G proteins. Its function is mediated through the activation of several signaling pathways including phospholipase C (PLC), intracellular calcium, mitogen-activated protein kinase (MAPK), I-kappaB kinase/NF-kappaB and Rho. Can also be transactivated by cleaved F2R/PAR1. Involved in modulation of inflammatory responses and regulation of innate and adaptive immunity, and acts as a sensor for proteolytic enzymes generated during infection. Generally is promoting inflammation. Can signal synergistically with TLR4 and probably TLR2 in inflammatory responses and modulates TLR3 signaling. Has a protective role in establishing the endothelial barrier; the activity involves coagulation factor X. Regulates endothelial cell barrier integrity during neutrophil extravasation, probably following proteolytic cleavage by PRTN3. Proposed to have a bronchoprotective role in airway epithelium, but also shown to compromise the airway epithelial barrier by interrupting E-cadherin adhesion. Involved in the regulation of vascular tone; activation results in hypotension presumably mediated by vasodilation. Associates with a subset of G proteins alpha subunits such as GNAQ, GNA11, GNA14, GNA12 and GNA13, but probably not with G(o) alpha, G(i) subunit alpha-1 and G(i) subunit alpha-2. Believed to be a class B receptor which internalizes as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptor, for extended periods of time. Mediates inhibition of TNF-alpha stimulated JNK phosphorylation via coupling to GNAQ and GNA11; the function involves dissociation of RIPK1 and TRADD from TNFR1. Mediates phosphorylation of nuclear factor NF-kappa-B RELA subunit at 'Ser-536'; the function involves IKBKB and is predominantly independent of G proteins. Involved in cellular migration. Involved in cytoskeletal rearrangement and chemotaxis through beta-arrestin-promoted scaffolds; the function is independent of GNAQ and GNA11 and involves promotion of cofilin dephosphorylation and actin filament severing. Induces redistribution of COPS5 from the plasma membrane to the cytosol and activation of the JNK cascade is mediated by COPS5. Involved in the recruitment of leukocytes to the sites of inflammation and is the major PAR receptor capable of modulating eosinophil function such as pro-inflammatory cytokine secretion, superoxide production and degranulation. During inflammation promotes dendritic cell maturation, trafficking to the lymph nodes and subsequent T-cell activation. Involved in antimicrobial response of innate immune cells; activation enhances phagocytosis of Gram-positive and killing of Gram-negative bacteria. Acts synergistically with interferon-gamma in enhancing antiviral responses. Probably mediates activation of pro-inflammatory and pro-fibrotic responses in fibroblasts, triggered by coagulation factor Xa (F10) (By similarity). Probably mediates activation of barrier protective signaling responses in endothelial cells, triggered by coagulation factor Xa (F10) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015057 thrombin-activated receptor activity;GO:0031681 G-protein beta-subunit binding;GO:0004930 G protein-coupled receptor activity;GO:0001965 G-protein alpha-subunit binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031143 pseudopodium", "go_biological_process": "GO:1900135 positive regulation of renin secretion into blood stream;GO:0006954 inflammatory response;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2HJA4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2HJF9-1", "uniprot_id": [ { "id": "RSAD2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2HJF9", "type": "external" } ], "mass": 41672.0, "length": 363, "protein_name": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2", "gene_name": "RSAD2", "organism": "Bovine", "refseq_name": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2", "refseq_ac": [ { "id": "NP_001039406", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039406", "type": "external" } ], "gene_names_uniprotkb": "RSAD2", "gene_names_refseq": "RSAD2; SAND", "protein_names_uniprotkb": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; 4.2.-.-; Radical S-adenosyl methionine domain-containing protein 2; SAND; Viperin; Virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible", "protein_names_refseq": "S-adenosylmethionine-dependent nucleotide dehydratase RSAD2; radical S-adenosyl methionine domain-containing protein 2; viperin; virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible", "tax_id": 9913, "disease": "", "pathway": " (bta:506415)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyszes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses. Also promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.-.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0016829 lyase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0043367 CD4-positive, alpha-beta T cell differentiation;GO:0035710 CD4-positive, alpha-beta T cell activation;GO:0050709 negative regulation of protein secretion;GO:0045087 innate immune response;GO:0051607 defense response to virus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2HJF9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KHZ8-1", "uniprot_id": [ { "id": "GBA1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KHZ8", "type": "external" } ], "mass": 59855.0, "length": 536, "protein_name": "Lysosomal acid glucosylceramidase", "gene_name": "GBA1", "organism": "Bovine", "refseq_name": "lysosomal acid glucosylceramidase precursor", "refseq_ac": [ { "id": "NP_001039886", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039886", "type": "external" } ], "gene_names_uniprotkb": "GBA1; GBA", "gene_names_refseq": "GBA1; GBA", "protein_names_uniprotkb": "Lysosomal acid glucosylceramidase; 2.4.1.-; 3.2.1.-; 3.2.1.45; 3.2.1.46; Acid beta-glucosidase; Beta-glucocerebrosidase; Cholesterol glucosyltransferase; Cholesteryl-beta-glucosidase; D-glucosyl-N-acylsphingosine glucohydrolase; Lysosomal cholesterol glycosyltransferase; Lysosomal galactosylceramidase; Lysosomal glycosylceramidase; SGTase", "protein_names_refseq": "D-glucosyl-N-acylsphingosine glucohydrolase; SGTase; acid (includes glucosylceramidase); acid beta-glucosidase; beta-glucocerebrosidase; cholesterol glucosyltransferase; cholesteryl-beta-glucosidase; glucocerebrosidase-like protein; glucosidase, beta; lysosomal acid glucosylceramidase precursor; lysosomal acid glucosylceramidase; lysosomal cholesterol glycosyltransferase; lysosomal galactosylceramidase; lysosomal glycosylceramidase", "tax_id": 9913, "disease": "", "pathway": " (bta:537087)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "Glucosylceramidase that catalyzes, within the lysosomal compartment, the hydrolysis of glucosylceramides/GlcCers (such as beta-D-glucosyl-(1<->1')-N-acylsphing-4-enine) into free ceramides (such as N-acylsphing-4-enine) and glucose. Plays a central role in the degradation of complex lipids and the turnover of cellular membranes. Through the production of ceramides, participates in the PKC-activated salvage pathway of ceramide formation. Catalyzes the glucosylation of cholesterol, through a transglucosylation reaction where glucose is transferred from GlcCer to cholesterol. GlcCer containing mono-unsaturated fatty acids (such as beta-D-glucosyl-N-(9Z-octadecenoyl)-sphing-4-enine) are preferred as glucose donors for cholesterol glucosylation when compared with GlcCer containing same chain length of saturated fatty acids (such as beta-D-glucosyl-N-octadecanoyl-sphing-4-enine). Under specific conditions, may alternatively catalyze the reverse reaction, transferring glucose from cholesteryl 3-beta-D-glucoside to ceramide. Can also hydrolyze cholesteryl 3-beta-D-glucoside producing glucose and cholesterol. Catalyzes the hydrolysis of galactosylceramides/GalCers (such as beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine), as well as the transfer of galactose between GalCers and cholesterol in vitro, but with lower activity than with GlcCers. Contrary to GlcCer and GalCer, xylosylceramide/XylCer (such as beta-D-xyosyl-(1<->1')-N-acylsphing-4-enine) is not a good substrate for hydrolysis, however it is a good xylose donor for transxylosylation activity to form cholesteryl 3-beta-D-xyloside., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.45", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.45", "type": "external" }, { "id": "3.2.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.21", "type": "external" }, { "id": "3.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.46", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0004348 glucosylceramidase activity;GO:0005102 signaling receptor binding;GO:0046527 glucosyltransferase activity;GO:0004336 galactosylceramidase activity;GO:0050295 steryl-beta-glucosidase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0005802 trans-Golgi network", "go_biological_process": "GO:0006680 glucosylceramide catabolic process;GO:0008203 cholesterol metabolic process;GO:0042391 regulation of membrane potential;GO:0016241 regulation of macroautophagy;GO:0006914 autophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KHZ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KI07-1", "uniprot_id": [ { "id": "ARL8B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KI07", "type": "external" } ], "mass": 21511.0, "length": 186, "protein_name": "ADP-ribosylation factor-like protein 8B", "gene_name": "ARL8B", "organism": "Bovine", "refseq_name": "ADP-ribosylation factor-like protein 8B", "refseq_ac": [ { "id": "NP_001039536", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039536", "type": "external" } ], "gene_names_uniprotkb": "ARL8B", "gene_names_refseq": "ARL8B", "protein_names_uniprotkb": "ADP-ribosylation factor-like protein 8B; 3.6.5.2", "protein_names_refseq": "ADP-ribosylation factor-like 8B; ADP-ribosylation factor-like protein 8B", "tax_id": 9913, "disease": "", "pathway": " (bta:511009)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion. Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense (By similarity). Recruits RUFY1 onto early endosomes regulating endosomes to trans-Golgi network proteins retrieval (By similarity). Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes. Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing. Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (By similarity). Involved in the process of MHC II presentation. Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity). May play a role in chromosome segregation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0005819 spindle;GO:0005829 cytosol;GO:0045202 synapse;GO:0005764 lysosome;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0001778 plasma membrane repair;GO:0007059 chromosome segregation;GO:0015031 protein transport;GO:0051301 cell division;GO:0008089 anterograde axonal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KI07-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KI14-1", "uniprot_id": [ { "id": "NAA10_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KI14", "type": "external" } ], "mass": 26521.0, "length": 235, "protein_name": "N-alpha-acetyltransferase 10", "gene_name": "NAA10", "organism": "Bovine", "refseq_name": "N-alpha-acetyltransferase 10", "refseq_ac": [ { "id": "NP_001039976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039976", "type": "external" } ], "gene_names_uniprotkb": "NAA10; ARD1A", "gene_names_refseq": "ARD1A; NAA10", "protein_names_uniprotkb": "N-alpha-acetyltransferase 10; 2.3.1.255; N-terminal acetyltransferase complex ARD1 subunit homolog A; NatA catalytic subunit Naa10", "protein_names_refseq": "ARD1 homolog A, N-acetyltransferase; N-alpha-acetyltransferase 10; N-terminal acetyltransferase complex ARD1 subunit homolog A; alpha-N-acetyltransferase 1A; natA catalytic subunit Naa10", "tax_id": 9913, "disease": "", "pathway": " (bta:613636)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase activity (By similarity). Acetylates amino termini that are devoid of initiator methionine (By similarity). The alpha (N-terminal) acetyltransferase activity may be important for vascular, hematopoietic and neuronal growth and development (By similarity). Without NAA15, displays epsilon (internal) acetyltransferase activity towards HIF1A, thereby promoting its degradation (By similarity). Represses MYLK kinase activity by acetylation, and thus represses tumor cell migration (By similarity). Acetylates, and stabilizes TSC2, thereby repressing mTOR activity and suppressing cancer development (By similarity). Acetylates HSPA1A and HSPA1B at 'Lys-77' which enhances its chaperone activity and leads to preferential binding to co-chaperone HOPX (By similarity). Acetylates HIST1H4A. Acts as a negative regulator of sister chromatid cohesion during mitosis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.255", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.255", "type": "external" } ], "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:1990189 protein N-terminal-serine acetyltransferase activity;GO:1990190 protein-N-terminal-glutamate acetyltransferase activity;GO:0008999 protein-N-terminal-alanine acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031415 NatA complex", "go_biological_process": "GO:2000719 negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KI14-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KI18-1", "uniprot_id": [ { "id": "PLPL2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KI18", "type": "external" } ], "mass": 53417.0, "length": 486, "protein_name": "Patatin-like phospholipase domain-containing protein 2", "gene_name": "PNPLA2", "organism": "Bovine", "refseq_name": "patatin-like phospholipase domain-containing protein 2", "refseq_ac": [ { "id": "NP_001039470", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039470", "type": "external" } ], "gene_names_uniprotkb": "PNPLA2; ATGL", "gene_names_refseq": "ATGL; PNPLA2", "protein_names_uniprotkb": "Patatin-like phospholipase domain-containing protein 2; 3.1.1.3; 3.1.1.4; Adipose triglyceride lipase; Calcium-independent phospholipase A2-zeta; iPLA2-zeta", "protein_names_refseq": "adipose triglyceride lipase; calcium-independent phospholipase A2-zeta; iPLA2-zeta; patatin-like phospholipase domain-containing protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:508493)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20886305", "class_list": "", "function": "Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (By similarity). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (By similarity). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (By similarity). Regulates adiposome size and may be involved in the degradation of adiposomes (By similarity). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (By similarity). Acts antagonistically with LDAH in regulation of cellular lipid stores (By similarity). Inhibits LDAH-stimulated lipid droplet fusion (By similarity). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Tissue distribution of ATGL gene expression was highest in fat and muscle (skeletal and cardiac) tissue, while protein expression was solely detectible in the adipose tissue., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5", "type": "external" }, { "id": "3.1.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23", "type": "external" }, { "id": "3.1.1.79", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79", "type": "external" }, { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "2.3.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20", "type": "external" }, { "id": "3.1.1.116", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.1.1.34", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34", "type": "external" }, { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" }, { "id": "2.3.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0004806 triacylglycerol lipase activity;GO:0050253 retinyl-palmitate esterase activity;GO:0051264 mono-olein transacylation activity;GO:0051265 diolein transacylation activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0010891 negative regulation of triglyceride storage;GO:0010898 positive regulation of triglyceride catabolic process;GO:0055088 lipid homeostasis;GO:0006651 diacylglycerol biosynthetic process;GO:0019433 triglyceride catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KI18-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KI78-1", "uniprot_id": [ { "id": "NDP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KI78", "type": "external" } ], "mass": 14978.0, "length": 133, "protein_name": "Norrin", "gene_name": "NDP", "organism": "Bovine", "refseq_name": "norrin precursor", "refseq_ac": [ { "id": "NP_001039555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039555", "type": "external" } ], "gene_names_uniprotkb": "NDP", "gene_names_refseq": "NDP", "protein_names_uniprotkb": "Norrin; Norrie disease protein homolog", "protein_names_refseq": "NDP, norrin cystine knot growth factor; Norrie disease (pseudoglioma); norrie disease protein homolog; norrin precursor; norrin", "tax_id": 9913, "disease": "", "pathway": " (bta:511596)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0042803 protein homodimerization activity;GO:0005125 cytokine activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface", "go_biological_process": "GO:0007399 nervous system development;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0016055 Wnt signaling pathway;GO:0035426 extracellular matrix-cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KI78-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KI99-1", "uniprot_id": [ { "id": "STING_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KI99", "type": "external" } ], "mass": 41941.0, "length": 378, "protein_name": "Stimulator of interferon genes protein", "gene_name": "STING1", "organism": "Bovine", "refseq_name": "stimulator of interferon genes protein", "refseq_ac": [ { "id": "NP_001039822", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039822", "type": "external" } ], "gene_names_uniprotkb": "STING1; STING; TMEM173", "gene_names_refseq": "STING1; STING; TMEM173", "protein_names_uniprotkb": "Stimulator of interferon genes protein; STING; Transmembrane protein 173", "protein_names_refseq": "stimulator of interferon genes protein; transmembrane protein 173", "tax_id": 9913, "disease": "", "pathway": " (bta:533661); (R-BTA-1834941); (R-BTA-3134975); (R-BTA-3249367); (R-BTA-3270619); (R-BTA-6798695)", "pathway_count": 6, "publication_count": 1, "publication_id_list": "38412580", "class_list": "", "function": "Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, cyclic UMP-AMP (2',3'-cUAMP), and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding to c-di-GMP or cGAMP, STING oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state. Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP. The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, which adopts an organized free-ligand conformation that resembles the STING1-bound conformation and pays low energy costs in changing into the active conformation. In addition to promote the production of type I interferons, plays a direct role in autophagy. Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome. Promotes autophagy by acting as a proton channel that directs proton efflux from the Golgi to facilitate MAP1LC3B/LC3B lipidation. The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation. Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II)., [UniProtKB, UniProtKB, UniProtKB]; Tegument protein UL3 of bovine herpesvirus 1 suppresses antiviral IFN-I signaling by targeting STING for autophagic degradation., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0035591 signaling adaptor activity;GO:0015252 proton channel activity;GO:0035438 cyclic-di-GMP binding;GO:0061507 2',3'-cyclic GMP-AMP binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0000421 autophagosome membrane;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0000045 autophagosome assembly;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0016239 positive regulation of macroautophagy;GO:0002218 activation of innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KI99-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIN8-1", "uniprot_id": [ { "id": "TF2B_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIN8", "type": "external" } ], "mass": 34891.0, "length": 316, "protein_name": "Transcription initiation factor IIB", "gene_name": "GTF2B", "organism": "Bovine", "refseq_name": "transcription initiation factor IIB", "refseq_ac": [ { "id": "NP_001039607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039607", "type": "external" } ], "gene_names_uniprotkb": "GTF2B", "gene_names_refseq": "GTF2B", "protein_names_uniprotkb": "Transcription initiation factor IIB; 2.3.1.48; General transcription factor TFIIB", "protein_names_refseq": "general transcription factor TFIIB; transcription initiation factor IIB", "tax_id": 9913, "disease": "", "pathway": " (bta:513231)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Also exhibits autoacetyltransferase activity that contributes to the activated transcription., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0008270 zinc ion binding;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0000993 RNA polymerase II complex binding;GO:0017025 TBP-class protein binding", "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005694 chromosome;GO:0032993 protein-DNA complex", "go_biological_process": "GO:0019083 viral transcription;GO:0006366 transcription by RNA polymerase II;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006473 protein acetylation;GO:0006352 DNA-templated transcription initiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIN8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIP2-1", "uniprot_id": [ { "id": "HASP_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIP2", "type": "external" } ], "mass": 86411.0, "length": 781, "protein_name": "Serine/threonine-protein kinase haspin", "gene_name": "HASPIN", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase haspin", "refseq_ac": [ { "id": "NP_001070012", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070012", "type": "external" } ], "gene_names_uniprotkb": "HASPIN; GSG2", "gene_names_refseq": "GSG2; HASPIN", "protein_names_uniprotkb": "Serine/threonine-protein kinase haspin; 2.7.11.1; Germ cell-specific gene 2 protein", "protein_names_refseq": "germ cell associated 2, haspin; germ cell-specific gene 2 protein; serine/threonine-protein kinase haspin", "tax_id": 9913, "disease": "", "pathway": " (bta:767819)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0072354 histone H3T3 kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle;GO:0005694 chromosome", "go_biological_process": "GO:0071459 protein localization to chromosome, centromeric region;GO:0000278 mitotic cell cycle;GO:0035556 intracellular signal transduction;GO:0007094 mitotic spindle assembly checkpoint signaling;GO:0007064 mitotic sister chromatid cohesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIP2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIP8-1", "uniprot_id": [ { "id": "HACD2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIP8", "type": "external" } ], "mass": 28422.0, "length": 254, "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2", "gene_name": "HACD2", "organism": "Bovine", "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2", "refseq_ac": [ { "id": "NP_001124229", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124229", "type": "external" } ], "gene_names_uniprotkb": "HACD2; PTPLB", "gene_names_refseq": "HACD2; PTPLB", "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2; 3-hydroxyacyl-CoA dehydratase 2; 4.2.1.134; HACD2; Protein-tyrosine phosphatase-like member B", "protein_names_refseq": "protein tyrosine phosphatase-like (proline instead of catalytic arginine), member b; protein-tyrosine phosphatase-like member B; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:613886)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.134", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.134", "type": "external" } ], "go_molecular_function": "GO:0019899 enzyme binding;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KIP8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KIR7-1", "uniprot_id": [ { "id": "GLYAT_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KIR7", "type": "external" } ], "mass": 33907.0, "length": 295, "protein_name": "Glycine N-acyltransferase", "gene_name": "GLYAT", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GLYAT", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycine N-acyltransferase; 2.3.1.13; 2.3.1.71; AAc; Acyl-CoA:glycine N-acyltransferase; Aralkyl acyl-CoA N-acyltransferase; Aralkyl acyl-CoA:amino acid N-acyltransferase; Benzoyl-coenzyme A:glycine N-acyltransferase; Glycine N-benzoyltransferase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:281787)", "pathway_count": 1, "publication_count": 4, "publication_id_list": "1445276;22071172;457678;9110242", "class_list": "", "function": "Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid., [UniProtKB, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "O46686", "ec_number_list": [ { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.13", "type": "external" }, { "id": "2.3.1.71", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.71", "type": "external" } ], "go_molecular_function": "GO:0047962 glycine N-benzoyltransferase activity;GO:0047961 glycine N-acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0009636 response to toxic substance;GO:0006544 glycine metabolic process;GO:0032787 monocarboxylic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.5, "record_id": "Q2KIR7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJB7-1", "uniprot_id": [ { "id": "CPT2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJB7", "type": "external" } ], "mass": 74483.0, "length": 658, "protein_name": "Carnitine O-palmitoyltransferase 2, mitochondrial", "gene_name": "CPT2", "organism": "Bovine", "refseq_name": "carnitine O-palmitoyltransferase 2, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001039354", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039354", "type": "external" } ], "gene_names_uniprotkb": "CPT2", "gene_names_refseq": "CPT2", "protein_names_uniprotkb": "Carnitine O-palmitoyltransferase 2, mitochondrial; 2.3.1.21; CPT II; Carnitine palmitoyltransferase II", "protein_names_refseq": "CPT II; carnitine O-palmitoyltransferase 2, mitochondrial precursor; carnitine O-palmitoyltransferase 2, mitochondrial; carnitine palmitoyltransferase II", "tax_id": 9913, "disease": "", "pathway": " (bta:504502)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "20546068", "class_list": "", "function": "Involved in the intramitochondrial synthesis of acylcarnitines from accumulated acyl-CoA metabolites. Reconverts acylcarnitines back into the respective acyl-CoA esters that can then undergo beta-oxidation, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Active with medium (C8-C12) and long-chain (C14-C18) acyl-CoA esters., [UniProtKB, UniProtKB]; It was conclude that suppression of CPT activity by positive energy balance appears to be specific for the liver in mid-lactating dairy cows., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.137", "type": "external" }, { "id": "2.3.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.7", "type": "external" }, { "id": "2.3.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.21", "type": "external" } ], "go_molecular_function": "GO:0004095 carnitine O-palmitoyltransferase activity;GO:0008458 carnitine O-octanoyltransferase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0001676 long-chain fatty acid metabolic process;GO:0006635 fatty acid beta-oxidation;GO:0015909 long-chain fatty acid transport;GO:0009437 carnitine metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KJB7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJC3-1", "uniprot_id": [ { "id": "MPEG1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJC3", "type": "external" } ], "mass": 78413.0, "length": 717, "protein_name": "Macrophage-expressed gene 1 protein", "gene_name": "MPEG1", "organism": "Bovine", "refseq_name": "macrophage-expressed gene 1 protein precursor", "refseq_ac": [ { "id": "NP_001039929", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039929", "type": "external" } ], "gene_names_uniprotkb": "MPEG1", "gene_names_refseq": "MPEG1; Mpg-1; P-2", "protein_names_uniprotkb": "Macrophage-expressed gene 1 protein; Macrophage gene 1 protein; Mpg-1; P-2; Perforin-2", "protein_names_refseq": "macrophage expressed gene 1; macrophage gene 1 protein; macrophage-expressed gene 1 protein precursor; macrophage-expressed gene 1 protein; perforin-2", "tax_id": 9913, "disease": "", "pathway": " (bta:539997)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Pore-forming protein involved in both innate and adaptive immunity. Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation. Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria. Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol. Required for the antibacterial activity of reactive oxygen species and nitric oxide., [UniProtKB, UniProtKB]; Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation. Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8(+) T-cells. Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022829 wide pore channel activity", "go_cellular_component": "GO:0031410 cytoplasmic vesicle;GO:0030670 phagocytic vesicle membrane;GO:0045335 phagocytic vesicle;GO:0061474 phagolysosome membrane", "go_biological_process": "GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0002468 dendritic cell antigen processing and presentation;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002250 adaptive immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJC3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJC9-1", "uniprot_id": [ { "id": "AL7A1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJC9", "type": "external" } ], "mass": 58582.0, "length": 539, "protein_name": "Alpha-aminoadipic semialdehyde dehydrogenase", "gene_name": "ALDH7A1", "organism": "Bovine", "refseq_name": "alpha-aminoadipic semialdehyde dehydrogenase", "refseq_ac": [ { "id": "NP_001039434", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039434", "type": "external" } ], "gene_names_uniprotkb": "ALDH7A1", "gene_names_refseq": "ALDH7A1", "protein_names_uniprotkb": "Alpha-aminoadipic semialdehyde dehydrogenase; 1.2.1.31; 1.2.1.3; 1.2.1.8; Aldehyde dehydrogenase family 7 member A1; Alpha-AASA dehydrogenase; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase", "protein_names_refseq": "P6c dehydrogenase; aldehyde dehydrogenase family 7 member A1; alpha-AASA dehydrogenase; alpha-aminoadipic semialdehyde dehydrogenase; antiquitin-1; betaine aldehyde dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenase; delta1-piperideine-6-carboxylate dehydrogenease", "tax_id": 9913, "disease": "", "pathway": " (bta:507477)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Aldehyde dehydrogenase enzyme that mediates important protective effects (By similarity). Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes (By similarity). Involved in lysine catabolism in the brain by mediating the conversion of L-aminoadipate-semialdehyde ((S)-2-amino-6-oxohexanoate) to L-2-aminoadipate (By similarity). Acts as a key inhibitor of ferroptosis both by generating membrane NADH and decreasing the level of reactive aldehydes (By similarity). Recruited to plasma membrane in response to ferroptotic stress and phosphorylation by AMPK, generating membrane NADH to support AIFM2/FSP1 activity, an essential ferroptosis suppressor protein (By similarity). Also directly inhibits ferroptosis by decreasing lipid peroxidation via consumption of reactive aldehydes, such as 4-hydroxynonenal (4-HNE) and malonaldehyde (By similarity). Also acts as a regulator of cellular energy homeostasis in response to cellular energy stress, such as starvation and hypoxia, by inhibiting COPI-mediated intracellular transport, thereby reducing cellular energy consumption (By similarity). Involved in cellular defense against hyperosmotic stress by metabolizing betaine aldehyde to betaine, an important cellular osmolyte and methyl donor (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0004043 L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity;GO:0008802 betaine-aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0006554 lysine catabolic process;GO:0097009 energy homeostasis;GO:0019285 glycine betaine biosynthetic process from choline;GO:0042997 negative regulation of Golgi to plasma membrane protein transport;GO:0110076 negative regulation of ferroptosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJC9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJH1-1", "uniprot_id": [ { "id": "BMP4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJH1", "type": "external" } ], "mass": 46626.0, "length": 409, "protein_name": "Bone morphogenetic protein 4", "gene_name": "BMP4", "organism": "Bovine", "refseq_name": "bone morphogenetic protein 4 precursor", "refseq_ac": [ { "id": "NP_001039342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039342", "type": "external" } ], "gene_names_uniprotkb": "BMP4", "gene_names_refseq": "BMP4", "protein_names_uniprotkb": "Bone morphogenetic protein 4; BMP-4", "protein_names_refseq": "BMP-4; bone morphogenetic protein 4 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:407216); (R-BTA-2129379); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 4, "publication_count": 8, "publication_id_list": "15629804;19083154;19661459;21281523;22330732;26660942;27486268;31363885", "class_list": "", "function": "BMP4 during maturation increased the proportion of Oct-4 positive cells in parthenogenic embryos. BMP4 is implicated in bovine oocytes maturation and embryo development. Publication Status: Online-Only, [RefSeq, PubMed]; Bone morphogenetic protein 4 and retinoic acid trigger bovine VASA homolog expression in differentiating bovine induced pluripotent stem cells., [RefSeq, PubMed]; Concluded that a bone morphogenetic protein (BMP)-signaling system, consisting of BMP2, BMP4, type II and I receptors, is present in bovine antral follicles and plays a role in development and functioning of follicles rather than in oocyte maturation, [RefSeq, PubMed]; Data indicate that the pro-angiogenic activity exerted by BMP4 in endothelial cells is mediated by a BMPR-mediated intracellular transactivation of VEGFR2 via c-Src., [RefSeq, PubMed]; Data report that BMP-7 suppresses granulosa cell apoptosis by inhibiting the release of caspase-activated DNase (CAD) via a mechanism which does not appear to be associated with the mitochondrial pathway, whereas BMP-4 inhibits the release of CAD., [RefSeq, PubMed]; Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (By similarity). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus (By similarity). Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling (By similarity). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (By similarity). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt, or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein., [RefSeq, PubMed]; High BMP4 expression is associated with cystic ovarian disease., [RefSeq, PubMed]; The BMP2/4 ligand and receptor system presides within bovine trophectoderm prior to uterine attachment. BMP4 negatively impacts CT1 cell growth Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 4, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:1901331 positive regulation of odontoblast differentiation;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0001822 kidney development;GO:0032967 positive regulation of collagen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.9, "record_id": "Q2KJH1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJH9-1", "uniprot_id": [ { "id": "AL9A1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJH9", "type": "external" } ], "mass": 53977.0, "length": 494, "protein_name": "4-trimethylaminobutyraldehyde dehydrogenase", "gene_name": "ALDH9A1", "organism": "Bovine", "refseq_name": "4-trimethylaminobutyraldehyde dehydrogenase", "refseq_ac": [ { "id": "NP_001039888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039888", "type": "external" } ], "gene_names_uniprotkb": "ALDH9A1", "gene_names_refseq": "ALDH9A1; TMABA-DH", "protein_names_uniprotkb": "4-trimethylaminobutyraldehyde dehydrogenase; 1.2.1.19; 1.2.1.3; 1.2.1.46; 1.2.1.47; Aldehyde dehydrogenase family 9 member A1; Formaldehyde dehydrogenase; Gamma-aminobutyraldehyde dehydrogenase; TMABA-DH; TMABADH", "protein_names_refseq": "4-trimethylaminobutyraldehyde dehydrogenase; TMABADH; aldehyde dehydrogenase family 9 member A1; formaldehyde dehydrogenase; gamma-aminobutyraldehyde dehydrogenase", "tax_id": 9913, "disease": "", "pathway": " (bta:537539)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "26495903", "class_list": "", "function": "Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "1.2.1.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.31", "type": "external" }, { "id": "1.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.8", "type": "external" }, { "id": "1.2.1.36", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36", "type": "external" }, { "id": "1.2.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.19", "type": "external" }, { "id": "1.2.1.28", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28", "type": "external" }, { "id": "1.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5", "type": "external" }, { "id": "1.2.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.47", "type": "external" }, { "id": "1.2.1.46", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.46", "type": "external" }, { "id": "1.7.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.1.-", "type": "external" }, { "id": "1.2.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7", "type": "external" }, { "id": "1.2.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48", "type": "external" } ], "go_molecular_function": "GO:0018467 formaldehyde dehydrogenase (NAD+) activity;GO:0004029 aldehyde dehydrogenase (NAD+) activity;GO:0019145 aminobutyraldehyde dehydrogenase (NAD+) activity;GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity;GO:0140087 acetaldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0006081 aldehyde metabolic process;GO:0045329 carnitine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2KJH9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJJ8-1", "uniprot_id": [ { "id": "PLD3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJJ8", "type": "external" } ], "mass": 54619.0, "length": 490, "protein_name": "5'-3' exonuclease PLD3", "gene_name": "PLD3", "organism": "Bovine", "refseq_name": "5'-3' exonuclease PLD3", "refseq_ac": [ { "id": "NP_001071509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071509", "type": "external" } ], "gene_names_uniprotkb": "PLD3", "gene_names_refseq": "PLD3", "protein_names_uniprotkb": "5'-3' exonuclease PLD3; (S,S)-bis(monoacylglycero)phosphate synthase PLD3; 2.3.1.-; 3.1.16.1; Phospholipase D3", "protein_names_refseq": "(S,S)-bis(monoacylglycero)phosphate synthase PLD3; 5'-3' exonuclease PLD3; PLD 3; choline phosphatase 3; phosphatidylcholine-hydrolyzing phospholipase D3; phospholipase D3", "tax_id": 9913, "disease": "", "pathway": " (bta:613932); (R-BTA-2029485)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "41018975", "class_list": "", "function": "Can alternatively catalyze the transfer (transphosphatidylation) of a glycerol group between (S,R)-lysophosphatidylglycerol (LPG) and monoacylglycerol (MAG). The reaction is characterized by an R-to-S stereo-inversion which is essential for the resistance of the produced (S,S)-bis(monoacylglycero)phosphates (BMPs) to lysosomal degradation. The resulting BMPs, are phospholipids required for the formation of lysosomal intralumenal vesicles (ILVs) where lipid degradation can occur., [UniProtKB, UniProtKB]; Lysosomal 5'->3' exonuclease that functions in nucleic-acid sensing by immune cells. Hydrolyzes phosphodiester bond in single-stranded RNA and DNA molecules, with a higher efficiency for molecules with 5' uridine and guanosine residues. It can stall at certain sites and does not necessarily proceed to complete exonucleolytic degradation, thereby producing nucleoside 3'-monophosphates but also 5'-end 5'-hydroxy deoxyribonucleotide/ribonucleotide fragments. Through the processing of self and exogenous RNA and DNA molecules, provides molecular signals to toll-like receptors (TLRs) in innate immunity. Partially redundant with PLD4, it cooperates with the RNase T2/RNASET2 to generate 2',3'-cGMP and cytidine-rich RNA fragments that occupy the two TLR7 ligand-binding pockets, to trigger receptor activation and signaling. Degrades mitochondrial CpG-rich ssDNA fragments to prevent TLR9 activation and autoinflammatory response, but it can cleave viral RNA to generate ligands for TLR7 activation and initiate antiviral immune responses. Can exert polynucleotide phosphatase activity toward 5'-phosphorylated single-stranded DNA substrates although at a slow rate. Regulates the homeostasis and interorganellar communication of the endolysosomal system with an overall impact on cellular removal of dysfunctional organelles via autophagy as well as proper protein and lipid turnover. May play a role in myotube formation in response to ER stress., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.1.16.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.16.1", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0035312 5'-3' DNA exonuclease activity;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005765 lysosomal membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system;GO:0031902 late endosome membrane", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006954 inflammatory response;GO:0014902 myotube differentiation;GO:1900015 regulation of cytokine production involved in inflammatory response;GO:0002376 immune system process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "Q2KJJ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2KJJ9-1", "uniprot_id": [ { "id": "F16P2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2KJJ9", "type": "external" } ], "mass": 36767.0, "length": 339, "protein_name": "Fructose-1,6-bisphosphatase isozyme 2", "gene_name": "FBP2", "organism": "Bovine", "refseq_name": "fructose-1,6-bisphosphatase isozyme 2", "refseq_ac": [ { "id": "NP_001039629", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039629", "type": "external" } ], "gene_names_uniprotkb": "FBP2", "gene_names_refseq": "FBP2", "protein_names_uniprotkb": "Fructose-1,6-bisphosphatase isozyme 2; 3.1.3.11; D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; FBPase 2; Muscle FBPase", "protein_names_refseq": "D-fructose-1,6-bisphosphate 1-phosphohydrolase 2; FBPase 2; fructose-1,6-bisphosphatase 2; fructose-1,6-bisphosphatase isozyme 2; muscle FBPase", "tax_id": 9913, "disease": "", "pathway": " (bta:514066); (R-BTA-70263)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.11", "type": "external" } ], "go_molecular_function": "GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030018 Z disc;GO:0070161 anchoring junction", "go_biological_process": "GO:0006094 gluconeogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2KJJ9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2LGB3-1", "uniprot_id": [ { "id": "IRAK1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2LGB3", "type": "external" } ], "mass": 77397.0, "length": 718, "protein_name": "Interleukin-1 receptor-associated kinase 1", "gene_name": "IRAK1", "organism": "Bovine", "refseq_name": "interleukin-1 receptor-associated kinase 1", "refseq_ac": [ { "id": "NP_001035645", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035645", "type": "external" } ], "gene_names_uniprotkb": "IRAK1", "gene_names_refseq": "IRAK1", "protein_names_uniprotkb": "Interleukin-1 receptor-associated kinase 1; 2.7.11.1; IRAK-1", "protein_names_refseq": "IRAK-1; interleukin-1 receptor-associated kinase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:533953); (R-BTA-1257604); (R-BTA-209543); (R-BTA-209560); (R-BTA-445989); (R-BTA-450302); (R-BTA-450321); (R-BTA-6811558); (R-BTA-9020702); (R-BTA-937039); (R-BTA-975144)", "pathway_count": 11, "publication_count": 4, "publication_id_list": "16621030;20072847;20127178;41018975", "class_list": "", "function": "ALOX5AP, CPNE3, IL1R2, IL6, TLR2, TLR4, and THY1 were upregulated in blood polymorphonuclear cells in negative energy balance versus positive energy balance cows., [RefSeq, PubMed]; Results describe a new full-length gene model for the bovine IRAK1 gene., [RefSeq, PubMed]; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0070498 interleukin-1-mediated signaling pathway;GO:0035556 intracellular signal transduction;GO:0045087 innate immune response;GO:0006355 regulation of DNA-templated transcription;GO:0043123 positive regulation of canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.7, "record_id": "Q2LGB3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2LGB7-1", "uniprot_id": [ { "id": "TCAM2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2LGB7", "type": "external" } ], "mass": 26511.0, "length": 232, "protein_name": "TIR domain-containing adapter molecule 2", "gene_name": "TICAM2", "organism": "Bovine", "refseq_name": "TIR domain-containing adapter molecule 2", "refseq_ac": [ { "id": "NP_001039921", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039921", "type": "external" } ], "gene_names_uniprotkb": "TICAM2; TRAM", "gene_names_refseq": "TICAM-2; TICAM2", "protein_names_uniprotkb": "TIR domain-containing adapter molecule 2; TICAM-2; TRIF-related adapter molecule", "protein_names_refseq": "TIR domain-containing adapter molecule 2; TRIF-related adapter molecule; toll like receptor adaptor molecule 2", "tax_id": 9913, "disease": "", "pathway": " (bta:539350); (R-BTA-140534); (R-BTA-166016); (R-BTA-166166); (R-BTA-2562578); (R-BTA-6798695); (R-BTA-936964); (R-BTA-937041); (R-BTA-937072); (R-BTA-975163); (R-BTA-9824878)", "pathway_count": 11, "publication_count": 1, "publication_id_list": "16621030", "class_list": "", "function": "Functions as a sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0006909 phagocytosis;GO:0032755 positive regulation of interleukin-6 production", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "Q2LGB7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2NKS0-1", "uniprot_id": [ { "id": "LTC4S_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2NKS0", "type": "external" } ], "mass": 16701.0, "length": 150, "protein_name": "Leukotriene C4 synthase", "gene_name": "LTC4S", "organism": "Bovine", "refseq_name": "leukotriene C4 synthase", "refseq_ac": [ { "id": "NP_001039563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039563", "type": "external" } ], "gene_names_uniprotkb": "LTC4S", "gene_names_refseq": "LTC4S", "protein_names_uniprotkb": "Leukotriene C4 synthase; 2.5.1.-; 4.4.1.20; Glutathione S-transferase LTC4; LTC4 synthase; Leukotriene-C(4) synthase", "protein_names_refseq": "LTC4 synthase; glutathione S-transferase LTC4; leukotriene C4 synthase; leukotriene-C(4) synthase", "tax_id": 9913, "disease": "", "pathway": " (bta:511749); (R-BTA-2142688); (R-BTA-2142691); (R-BTA-2142700); (R-BTA-9026762); (R-BTA-9026766)", "pathway_count": 6, "publication_count": 2, "publication_id_list": "16305752;25483008", "class_list": "", "function": "Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions., [UniProtKB, UniProtKB]; In luteal-phase endometrium, expression of 5-LO (5-lipoxygenase) and LTB4R (leukotriene B4 receptor) is highest on Days 2-4; expression of LTCS (leukotriene-C4 synthase) and CysLTR2 (cysteinyl leukotriene receptor 2) is highest on Days 16-18. In luteal-phase endometrium, LTB4 level is highest on Days 2-4; LTC4 level is highest on Days 16-18. Studies were conducted in Poland on Holstein Polish Black and White dairy cows., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" } ], "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004464 leukotriene-C4 synthase activity;GO:0008047 enzyme activator activity;GO:0004602 glutathione peroxidase activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "GO:0006691 leukotriene metabolic process;GO:0019370 leukotriene biosynthetic process;GO:0042759 long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2NKS0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2NKU9-1", "uniprot_id": [ { "id": "EMP2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2NKU9", "type": "external" } ], "mass": 18972.0, "length": 167, "protein_name": "Epithelial membrane protein 2", "gene_name": "EMP2", "organism": "Bovine", "refseq_name": "epithelial membrane protein 2", "refseq_ac": [ { "id": "NP_001068792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068792", "type": "external" } ], "gene_names_uniprotkb": "EMP2", "gene_names_refseq": "EMP2", "protein_names_uniprotkb": "Epithelial membrane protein 2; EMP-2", "protein_names_refseq": "EMP-2; epithelial membrane protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:507667)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a key regulator of cell membrane composition by regulating protein surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion. Regulates transepithelial migration of neutrophils into the alveolar lumen, potentially via mediation of cell surface expression of adhesion markers and lipid raft formation (By similarity). Negatively regulates caveolae formation by reducing CAV1 expression and CAV1 amount by increasing lysosomal degradation (By similarity). Facilitates surface trafficking and the formation of lipid rafts bearing GPI-anchor proteins (By similarity). Regulates surface expression of MHC1 and ICAM1 proteins increasing susceptibility to T-cell mediated cytotoxicity (By similarity). Regulates the plasma membrane expression of the integrin heterodimers ITGA6-ITGB1, ITGA5-ITGB3 and ITGA5-ITGB1 resulting in modulation of cell-matrix adhesion (By similarity). Also regulates many processes through PTK2 (By similarity). Regulates blood vessel endothelial cell migration and angiogenesis by regulating VEGF protein expression through PTK2 activation (By similarity). Regulates cell contraction through PTK2 activation (By similarity). Regulates focal adhesion density, F-actin conformation and cell adhesion capacity through interaction with PTK2. Positively regulates cell proliferation (By similarity). Plays a role during cell death and cell blebbing (By similarity). Promotes angiogenesis and vasculogenesis through induction of VEGFA via a HIF1A-dependent pathway (By similarity). Also plays a role in embryo implantation by regulating surface trafficking of integrin heterodimer ITGA5-ITGB3 (By similarity). Plays a role in placental angiogenesis and uterine natural killer cell regulation at the maternal-fetal placental interface, however not required in the maternal tissues for a viable pregnancy (By similarity). Involved in the early stages of embryogenic development and cardiogenesis, potentially via regulation of epithelial-mesenchymal transition timing (By similarity). May play a role in glomerular filtration (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0007155 cell adhesion;GO:0008284 positive regulation of cell population proliferation;GO:0072659 protein localization to plasma membrane;GO:0003093 regulation of glomerular filtration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2NKU9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2NL22-1", "uniprot_id": [ { "id": "IF4A3_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2NL22", "type": "external" } ], "mass": 46841.0, "length": 411, "protein_name": "Eukaryotic initiation factor 4A-III", "gene_name": "EIF4A3", "organism": "Bovine", "refseq_name": "eukaryotic initiation factor 4A-III", "refseq_ac": [ { "id": "NP_001039653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039653", "type": "external" } ], "gene_names_uniprotkb": "EIF4A3; DDX48", "gene_names_refseq": "EIF4A3", "protein_names_uniprotkb": "Eukaryotic initiation factor 4A-III; 3.6.4.13; ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD box protein 48; Eukaryotic translation initiation factor 4A isoform 3", "protein_names_refseq": "ATP-dependent RNA helicase DDX48; ATP-dependent RNA helicase eIF4A-3; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; DEAD box protein 48; eukaryotic initiation factor 4A-III", "tax_id": 9913, "disease": "", "pathway": " (bta:515145); (R-BTA-1169408); (R-BTA-159236); (R-BTA-429947); (R-BTA-72163); (R-BTA-975957)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The inhibition of ATPase activity by the MAGOH-RBM8A heterodimer increases the RNA-binding affinity of the EJC. Involved in translational enhancement of spliced mRNAs after formation of the 80S ribosome complex. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Shows higher affinity for single-stranded RNA in an ATP-bound core EJC complex than after the ATP is hydrolyzed. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. Involved in craniofacial development., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.1.13.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003729 mRNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0008143 poly(A) binding;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0006406 mRNA export from nucleus;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0017148 negative regulation of translation;GO:0045727 positive regulation of translation;GO:0048701 embryonic cranial skeleton morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2NL22-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2NL30-1", "uniprot_id": [ { "id": "SUV91_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2NL30", "type": "external" } ], "mass": 47846.0, "length": 412, "protein_name": "Histone-lysine N-methyltransferase SUV39H1", "gene_name": "SUV39H1", "organism": "Bovine", "refseq_name": "histone-lysine N-methyltransferase SUV39H1", "refseq_ac": [ { "id": "NP_001039729", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039729", "type": "external" } ], "gene_names_uniprotkb": "SUV39H1", "gene_names_refseq": "SUV39H1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase SUV39H1; 2.1.1.-; Su(var)3-9 homolog 1; Suppressor of variegation 3-9 homolog 1", "protein_names_refseq": "histone-lysine N-methyltransferase SUV39H1; su(var)3-9 homolog 1; suppressor of variegation 3-9 homolog 1", "tax_id": 9913, "disease": "", "pathway": " (bta:523047)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones (By similarity). Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats (By similarity). SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiation, regulation of the control switch for exiting the cell cycle and entering differentiation, repression by the PML-RARA fusion protein, BMP-induced repression, repression of switch recombination to IgA and regulation of telomere length. Involved in the maintenance of H3K9me3 mark following DNA replication, when histone marks are diluted: HP1 recognizes the preexisting H3K9me3 mark and serves as a platform to recruit SUV39H1 to modify the adjacent newly incorporated histones. Component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus (By similarity). Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.366", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.366", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0046974 histone H3K9 methyltransferase activity;GO:0140947 histone H3K9me2 methyltransferase activity;GO:0140258 histone H3K14ub reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005677 chromatin silencing complex;GO:0005652 nuclear lamina;GO:0000792 heterochromatin", "go_biological_process": "GO:0031508 pericentric heterochromatin formation;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045892 negative regulation of DNA-templated transcription;GO:0007623 circadian rhythm", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2NL30-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2PT36-1", "uniprot_id": [ { "id": "AICDA_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2PT36", "type": "external" } ], "mass": 24052.0, "length": 199, "protein_name": "Single-stranded DNA cytosine deaminase", "gene_name": "AICDA", "organism": "Bovine", "refseq_name": "single-stranded DNA cytosine deaminase", "refseq_ac": [ { "id": "NP_001033771", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033771", "type": "external" } ], "gene_names_uniprotkb": "AICDA", "gene_names_refseq": "AICDA; AID", "protein_names_uniprotkb": "Single-stranded DNA cytosine deaminase; 3.5.4.38; AID; Activation-induced cytidine deaminase; Cytidine aminohydrolase", "protein_names_refseq": "cytidine aminohydrolase; single-stranded DNA cytosine deaminase", "tax_id": 9913, "disease": "", "pathway": " (bta:539888)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19766322;24459992", "class_list": "", "function": "AICDA cDNA was cloned and expressed successfully in Escherichia coli generating a phenotype consistent with the mutating action of this deaminase. Using a whole genome radiation hybrid panel, AICDA was mapped to a region of chromosome 5., [RefSeq, PubMed]; Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation., [UniProtKB, UniProtKB]; TET3 dioxygenase was present in the very first embryo stages, in contrast to TET1 and AICDA., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.4.38", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.38", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004126 cytidine deaminase activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000932 P-body", "go_biological_process": "GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0006397 mRNA processing;GO:0016554 cytidine to uridine editing;GO:0051607 defense response to virus;GO:0070383 DNA cytosine deamination", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "Q2PT36-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9M1-1", "uniprot_id": [ { "id": "PICK1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9M1", "type": "external" } ], "mass": 46729.0, "length": 417, "protein_name": "PRKCA-binding protein", "gene_name": "PICK1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PICK1; PRKCABP", "gene_names_refseq": "", "protein_names_uniprotkb": "PRKCA-binding protein; Protein interacting with C kinase 1; Protein kinase C-alpha-binding protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005543 phospholipid binding;GO:0019904 protein domain specific binding;GO:0046872 metal ion binding;GO:0051015 actin filament binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005886 plasma membrane;GO:0014069 postsynaptic density;GO:0032588 trans-Golgi network membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0021782 glial cell development;GO:0036294 cellular response to decreased oxygen levels;GO:0006886 intracellular protein transport;GO:0060292 long-term synaptic depression;GO:0097061 dendritic spine organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2T9M1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2T9M7-1", "uniprot_id": [ { "id": "P20D1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2T9M7", "type": "external" } ], "mass": 55785.0, "length": 503, "protein_name": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1", "gene_name": "PM20D1", "organism": "Bovine", "refseq_name": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1 precursor", "refseq_ac": [ { "id": "NP_001033189", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033189", "type": "external" } ], "gene_names_uniprotkb": "PM20D1", "gene_names_refseq": "PM20D1", "protein_names_uniprotkb": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1; 3.5.1.114; 3.5.1.14; Peptidase M20 domain-containing protein 1", "protein_names_refseq": "N-fatty-acyl-amino acid synthase/hydrolase PM20D1 precursor; N-fatty-acyl-amino acid synthase/hydrolase PM20D1; peptidase M20 domain-containing protein 1; probable carboxypeptidase PM20D1", "tax_id": 9913, "disease": "", "pathway": " (bta:513852)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.99", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.99", "type": "external" }, { "id": "3.5.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.114", "type": "external" }, { "id": "3.5.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.14", "type": "external" } ], "go_molecular_function": "GO:0004046 aminoacylase activity;GO:0046872 metal ion binding;GO:0008233 peptidase activity;GO:0016829 lyase activity;GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis;GO:0006629 lipid metabolic process;GO:0006631 fatty acid metabolic process;GO:0097009 energy homeostasis;GO:0006520 amino acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2T9M7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TA29-1", "uniprot_id": [ { "id": "RB11A_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TA29", "type": "external" } ], "mass": 24470.0, "length": 216, "protein_name": "Ras-related protein Rab-11A", "gene_name": "RAB11A", "organism": "Bovine", "refseq_name": "ras-related protein Rab-11A", "refseq_ac": [ { "id": "NP_001033251", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033251", "type": "external" } ], "gene_names_uniprotkb": "RAB11A; RAB11", "gene_names_refseq": "RAB11A; Rab-11", "protein_names_uniprotkb": "Ras-related protein Rab-11A; 3.6.5.2; Rab-11", "protein_names_refseq": "ras-related protein Rab-11A", "tax_id": 9913, "disease": "", "pathway": " (bta:534708)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB11A regulates endocytic recycling. Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC). Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (By similarity). Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation. On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth. Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (By similarity). Also interacts with RABL3 to promote ciliary vesicle formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0051959 dynein light intermediate chain binding;GO:0003925 G protein activity", "go_cellular_component": "GO:0098837 postsynaptic recycling endosome;GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0005929 cilium;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0031175 neuron projection development;GO:0072659 protein localization to plasma membrane;GO:0006887 exocytosis;GO:0032402 melanosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TA29-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBN3-1", "uniprot_id": [ { "id": "CETN2_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBN3", "type": "external" } ], "mass": 19810.0, "length": 172, "protein_name": "Centrin-2", "gene_name": "CETN2", "organism": "Bovine", "refseq_name": "centrin-2", "refseq_ac": [ { "id": "NP_001033604", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033604", "type": "external" } ], "gene_names_uniprotkb": "CETN2", "gene_names_refseq": "CETN2", "protein_names_uniprotkb": "Centrin-2", "protein_names_refseq": "centrin, EF-hand protein, 2; centrin-2", "tax_id": 9913, "disease": "", "pathway": " (bta:508601); (R-BTA-2565942); (R-BTA-3108214); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-5696394); (R-BTA-5696395); (R-BTA-8854518)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores., [UniProtKB, UniProtKB]; Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer (By similarity)., [UniProtKB]; Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110 (By similarity)., [UniProtKB]; The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0031683 G-protein beta/gamma-subunit complex binding;GO:0032795 heterotrimeric G-protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0045177 apical part of cell", "go_biological_process": "GO:0007283 spermatogenesis;GO:0015031 protein transport;GO:0051301 cell division;GO:0000226 microtubule cytoskeleton organization;GO:0006289 nucleotide-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBN3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2TBT7-1", "uniprot_id": [ { "id": "FXR1_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2TBT7", "type": "external" } ], "mass": 69751.0, "length": 621, "protein_name": "RNA-binding protein FXR1", "gene_name": "FXR1", "organism": "Bovine", "refseq_name": "RNA-binding protein FXR1", "refseq_ac": [ { "id": "NP_001033651", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001033651", "type": "external" } ], "gene_names_uniprotkb": "FXR1", "gene_names_refseq": "FXR1", "protein_names_uniprotkb": "RNA-binding protein FXR1", "protein_names_refseq": "RNA-binding protein FXR1", "tax_id": 9913, "disease": "", "pathway": " (bta:536793)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis. Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors. Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site. Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts (By similarity). Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production. Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation. Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression. Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons. Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules (By similarity). Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism (By similarity). Plays a role in the stabilization of PKP2 mRNA and therefore protein abundance, via its interaction with PKP3 (By similarity). May also do the same for PKP2, PKP3 and DSP via its interaction with PKP1 (By similarity). Forms a cytoplasmic messenger ribonucleoprotein (mRNP) network by packaging long mRNAs, serving as a scaffold that recruits proteins and signaling molecules. This network facilitates signaling reactions by maintaining proximity between kinases and substrates, crucial for processes like actomyosin reorganization (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0003730 mRNA 3'-UTR binding;GO:0045182 translation regulator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0030424 axon;GO:0043197 dendritic spine;GO:0043005 neuron projection", "go_biological_process": "GO:0045187 regulation of circadian sleep/wake cycle, sleep;GO:1900272 negative regulation of long-term synaptic potentiation;GO:0010608 post-transcriptional regulation of gene expression;GO:0032720 negative regulation of tumor necrosis factor production;GO:0043488 regulation of mRNA stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2TBT7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "Q2YDD9-1", "uniprot_id": [ { "id": "ADT4_BOVIN", "url": "https://www.uniprot.org/uniprot/Q2YDD9", "type": "external" } ], "mass": 35694.0, "length": 323, "protein_name": "ADP/ATP translocase 4", "gene_name": "SLC25A31", "organism": "Bovine", "refseq_name": "ADP/ATP translocase 4", "refseq_ac": [ { "id": "NP_001039965", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039965", "type": "external" } ], "gene_names_uniprotkb": "SLC25A31", "gene_names_refseq": "SLC25A31", "protein_names_uniprotkb": "ADP/ATP translocase 4; ADP,ATP carrier protein 4; ANT 4; Adenine nucleotide translocator 4; Solute carrier family 25 member 31", "protein_names_refseq": "ADP,ATP carrier protein 4; ADP/ATP translocase 4; ANT 4; adenine nucleotide translocator 4; adenine nucleotide translocator), member 31; solute carrier family 25 (mitochondrial carrier", "tax_id": 9913, "disease": "", "pathway": " (bta:541168)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). Specifically required during spermatogenesis, probably to mediate ADP:ATP exchange in spermatocytes. Large ATP supplies from mitochondria may be critical for normal progression of spermatogenesis during early stages of meiotic prophase I, including DNA double-strand break repair and chromosomal synapsis. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (By similarity). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A31/ANT4 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Among nucleotides, may also exchange ADP for dATP and dADP (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A31/ANT4 constitutes a pore-forming component of mPTP or regulates it (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0005471 ATP:ADP antiporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016020 membrane;GO:0005757 mitochondrial permeability transition pore complex", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0046902 regulation of mitochondrial membrane permeability;GO:0007141 male meiosis I;GO:0140021 mitochondrial ADP transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "Q2YDD9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNH1-1", "uniprot_id": [ { "id": "KIZ_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNH1", "type": "external" } ], "mass": 80421.0, "length": 727, "protein_name": "Centrosomal protein kizuna", "gene_name": "KIZ", "organism": "Bovine", "refseq_name": "centrosomal protein kizuna", "refseq_ac": [ { "id": "NP_001156930", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156930", "type": "external" } ], "gene_names_uniprotkb": "KIZ; PLK1S1", "gene_names_refseq": "C13H20orf19; KIZ; NCRNA00153; PLK1S1", "protein_names_uniprotkb": "Centrosomal protein kizuna; Polo-like kinase 1 substrate 1", "protein_names_refseq": "centrosomal protein kizuna; polo-like kinase 1 substrate 1", "tax_id": 9913, "disease": "", "pathway": " (bta:513688)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0007051 spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNH1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNG4-1", "uniprot_id": [ { "id": "RN207_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNG4", "type": "external" } ], "mass": 61668.0, "length": 556, "protein_name": "RING finger protein 207", "gene_name": "RNF207", "organism": "Bovine", "refseq_name": "RING finger protein 207", "refseq_ac": [ { "id": "NP_001071525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071525", "type": "external" } ], "gene_names_uniprotkb": "RNF207", "gene_names_refseq": "RNF207", "protein_names_uniprotkb": "RING finger protein 207", "protein_names_refseq": "RING finger protein 207", "tax_id": 9913, "disease": "", "pathway": " (bta:616057)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in cardiac repolarization possibly by stabilizing membrane expression of the potassium channel KCNH2/HERG, or by assisting its synthesis, folding or export from the endoplasmic reticulum, in a heat shock protein-dependent manner., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q08D80", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044325 transmembrane transporter binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0055117 regulation of cardiac muscle contraction;GO:1901207 regulation of heart looping;GO:1905026 positive regulation of membrane repolarization during ventricular cardiac muscle cell action potential;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNG4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN62-1", "uniprot_id": [ { "id": "CE120_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JN62", "type": "external" } ], "mass": 112913.0, "length": 987, "protein_name": "Centrosomal protein of 120 kDa", "gene_name": "CEP120", "organism": "Bovine", "refseq_name": "centrosomal protein of 120 kDa", "refseq_ac": [ { "id": "NP_001071468", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071468", "type": "external" } ], "gene_names_uniprotkb": "CEP120; CCDC100", "gene_names_refseq": "CCDC100; CEP120", "protein_names_uniprotkb": "Centrosomal protein of 120 kDa; Cep120; Coiled-coil domain-containing protein 100", "protein_names_refseq": "centrosomal protein of 120 kDa; coiled-coil domain containing 100; coiled-coil domain-containing protein 100", "tax_id": 9913, "disease": "", "pathway": " (bta:534400)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors and for proper positioning of neurons during brain development. Also implicated in the migration and selfrenewal of neural progenitors. May play a role in centriole duplication during mitosis (By similarity). Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole", "go_biological_process": "GO:1904951 positive regulation of establishment of protein localization;GO:0007098 centrosome cycle;GO:0045724 positive regulation of cilium assembly;GO:1903724 positive regulation of centriole elongation;GO:0010825 positive regulation of centrosome duplication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JN62-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN71-1", "uniprot_id": [ { "id": "SASH3_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JN71", "type": "external" } ], "mass": 41566.0, "length": 380, "protein_name": "SAM and SH3 domain-containing protein 3", "gene_name": "SASH3", "organism": "Bovine", "refseq_name": "SAM and SH3 domain-containing protein 3", "refseq_ac": [ { "id": "NP_001071466", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071466", "type": "external" } ], "gene_names_uniprotkb": "SASH3", "gene_names_refseq": "HXCXORF9; SASH3", "protein_names_uniprotkb": "SAM and SH3 domain-containing protein 3", "protein_names_refseq": "SAM and SH3 domain-containing protein 3; SH3 protein expressed in lymphocytes", "tax_id": 9913, "disease": "", "pathway": " (bta:534137)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May function as a signaling adapter protein in lymphocytes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0030890 positive regulation of B cell proliferation;GO:1902531 regulation of intracellular signal transduction;GO:0002821 positive regulation of adaptive immune response;GO:0002639 positive regulation of immunoglobulin production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JN71-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN52-1", "uniprot_id": [ { "id": "SF3B3_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JN52", "type": "external" } ], "mass": 135577.0, "length": 1217, "protein_name": "Splicing factor 3B subunit 3", "gene_name": "SF3B3", "organism": "Bovine", "refseq_name": "splicing factor 3B subunit 3", "refseq_ac": [ { "id": "NP_001071319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071319", "type": "external" } ], "gene_names_uniprotkb": "SF3B3", "gene_names_refseq": "SF3B3", "protein_names_uniprotkb": "Splicing factor 3B subunit 3; Pre-mRNA-splicing factor SF3b 130 kDa subunit; SAP 130; SF3b130; Spliceosome-associated protein 130", "protein_names_refseq": "SAP 130; SF3b130; pre-mRNA-splicing factor SF3b 130 kDa subunit; spliceosome-associated protein 130; splicing factor 3B subunit 3; splicing factor 3b, subunit 3, 130kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:504962); (R-BTA-72163); (R-BTA-72165); (R-BTA-9770562); (R-BTA-9943411)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B3 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030620 U2 snRNA binding;GO:0044877 protein-containing complex binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP", "go_biological_process": "GO:0042177 negative regulation of protein catabolic process;GO:0000398 mRNA splicing, via spliceosome;GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JN52-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JND4-1", "uniprot_id": [ { "id": "SBNO2_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JND4", "type": "external" } ], "mass": 150374.0, "length": 1374, "protein_name": "Protein strawberry notch homolog 2", "gene_name": "SBNO2", "organism": "Bovine", "refseq_name": "protein strawberry notch homolog 2", "refseq_ac": [ { "id": "NP_001071379", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071379", "type": "external" } ], "gene_names_uniprotkb": "SBNO2", "gene_names_refseq": "SBNO2", "protein_names_uniprotkb": "Protein strawberry notch homolog 2", "protein_names_refseq": "protein strawberry notch homolog 2", "tax_id": 9913, "disease": "", "pathway": " (bta:512682)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation. Involved in the transcriptional corepression of NF-kappaB in macrophages. Plays a role as a regulator in the pro-inflammatory cascade., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Seems to have transcriptional repression activity in macrophages., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031490 chromatin DNA binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0071348 cellular response to interleukin-11;GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JND4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0A452DJA8-1", "uniprot_id": [ { "id": "A0A452DJA8_BOVIN", "url": "https://www.uniprot.org/uniprot/A0A452DJA8", "type": "external" } ], "mass": 36473.0, "length": 330, "protein_name": "Purine nucleoside phosphorylase", "gene_name": "PNP", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PNP", "gene_names_refseq": "", "protein_names_uniprotkb": "Purine nucleoside phosphorylase; 2.4.2.1; Inosine phosphorylase; Inosine-guanosine phosphorylase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6798695); (R-BTA-74217); (R-BTA-74259); (R-BTA-9755088)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Preferentially acts on 6-oxopurine nucleosides including inosine and guanosine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" }, { "id": "2.7.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.1", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "2.4.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.1", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "2.4.2.28", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.28", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.33", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.6", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "3.4.22.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.1.1.47", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47", "type": "external" }, { "id": "5.3.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.1", "type": "external" }, { "id": "5.3.3.12", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.12", "type": "external" }, { "id": "3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.4.21.46", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "4.1.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.4", "type": "external" }, { "id": "5.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.1.9", "type": "external" }, { "id": "5.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.1.3.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "2.4.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.7", "type": "external" }, { "id": "4.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.24", "type": "external" } ], "go_molecular_function": "GO:0004731 purine-nucleoside phosphorylase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006166 purine ribonucleoside salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0A452DJA8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNI8-1", "uniprot_id": [ { "id": "LHX9_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNI8", "type": "external" } ], "mass": 43889.0, "length": 397, "protein_name": "LIM/homeobox protein Lhx9", "gene_name": "LHX9", "organism": "Bovine", "refseq_name": "LIM/homeobox protein Lhx9 isoform X1", "refseq_ac": [ { "id": "XP_010811854", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811854", "type": "external" } ], "gene_names_uniprotkb": "LHX9", "gene_names_refseq": "LHX9", "protein_names_uniprotkb": "LIM/homeobox protein Lhx9; LIM homeobox protein 9", "protein_names_refseq": "LIM/homeobox protein Lhx9 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Involved in gonadal development., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0V893", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0030182 neuron differentiation;GO:0097380 dorsal spinal cord interneuron anterior axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0JNI8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9SA77-1", "uniprot_id": [ { "id": "A0AAA9SA77_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9SA77", "type": "external" } ], "mass": 36729.0, "length": 327, "protein_name": "Androgen induced 1", "gene_name": "AIG1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AIG1", "gene_names_refseq": "", "protein_names_uniprotkb": "Androgen induced 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", 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0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "3.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0042758 long-chain fatty acid catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9SA77-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9T4H8-1", "uniprot_id": [ { "id": "A0AAA9T4H8_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9T4H8", "type": "external" } ], "mass": 54611.0, "length": 508, "protein_name": "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial", "gene_name": "SUCLG2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SUCLG2", "gene_names_refseq": "", "protein_names_uniprotkb": "Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial; 6.2.1.4; G-SCS; GTP-specific succinyl-CoA synthetase subunit beta; GTPSCS; SCS-betaG; Succinyl-CoA synthetase beta-G chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Also able to act as a GTP-specific itaconyl- and malyl-CoA synthetase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" }, { "id": "6.2.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.5", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.9", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0004775 succinate-CoA ligase (ADP-forming) activity;GO:0004776 succinate-CoA ligase (GDP-forming) activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005737 cytoplasm;GO:0005759 mitochondrial matrix;GO:0045244 succinate-CoA ligase complex (GDP-forming)", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006104 succinyl-CoA metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9T4H8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9SJ11-1", "uniprot_id": [ { "id": "A0AAA9SJ11_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9SJ11", "type": "external" } ], "mass": 72731.0, "length": 677, "protein_name": "Acyl-CoA dehydrogenase very long chain", "gene_name": "ACADVL", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ACADVL", "gene_names_refseq": "", "protein_names_uniprotkb": "Acyl-CoA dehydrogenase very long chain", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on fatty acyl-CoAs with saturated 12 to 24 carbons long primary chains., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.8.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.7", "type": "external" }, { "id": "1.3.8.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.8", "type": "external" }, { "id": "1.3.8.9", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.9", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0017099 very-long-chain fatty acyl-CoA dehydrogenase activity;GO:0004466 long-chain fatty acyl-CoA dehydrogenase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006635 fatty acid beta-oxidation;GO:0001659 temperature homeostasis;GO:0030855 epithelial cell differentiation;GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase;GO:0045717 negative regulation of fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9SJ11-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNJ3-1", "uniprot_id": [ { "id": "SPART_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNJ3", "type": "external" } ], "mass": 72702.0, "length": 668, "protein_name": "Spartin", "gene_name": "SPART", "organism": "Bovine", "refseq_name": "spartin", "refseq_ac": [ { "id": "NP_001071464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071464", "type": "external" } ], "gene_names_uniprotkb": "SPART", "gene_names_refseq": "SPART; SPG20", "protein_names_uniprotkb": "Spartin", "protein_names_refseq": "spartin; spastic paraplegia 20 (Troyer syndrome)", "tax_id": 9913, "disease": "", "pathway": " (bta:534027)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lipophagy receptor that plays an important role in lipid droplet (LD) turnover in motor neurons. Localizes to LDs and interacts with components of the autophagy machinery, such as MAP1LC3A/C proteins to deliver LDs to autophagosomes for degradation via lipophagy. Lipid transfer protein required for lipid droplet degradation, including by lipophagy. Can bind and transfer all lipid species found in lipid droplets, from phospholipids to triglycerides and sterol esters but the direction of lipid transfer by spartin and its cargos are unknown. May be implicated in endosomal trafficking, or microtubule dynamics, or both. Participates in cytokinesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0005886 plasma membrane;GO:0030496 midbody;GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0051301 cell division;GO:0016042 lipid catabolic process;GO:0030514 negative regulation of BMP signaling pathway;GO:0061724 lipophagy", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNJ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9S2I6-1", "uniprot_id": [ { "id": "A0AAA9S2I6_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9S2I6", "type": "external" } ], "mass": 48458.0, "length": 420, "protein_name": "1-acyl-sn-glycerol-3-phosphate acyltransferase delta", "gene_name": "AGPAT4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AGPAT4", "gene_names_refseq": "", "protein_names_uniprotkb": "1-acyl-sn-glycerol-3-phosphate acyltransferase delta; 1-acylglycerol-3-phosphate O-acyltransferase 4; 2.3.1.51; Lysophosphatidic acid acyltransferase delta", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" } ], "go_molecular_function": "GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9S2I6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9S6A7-1", "uniprot_id": [ { "id": "A0AAA9S6A7_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9S6A7", "type": "external" } ], "mass": 169426.0, "length": 1411, "protein_name": "Eukaryotic translation initiation factor 3 subunit A", "gene_name": "EIF3A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EIF3A; EIF3S10", "gene_names_refseq": "", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 3 subunit A; Eukaryotic translation initiation factor 3 subunit 10; eIF-3-theta; eIF3a", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-156827); (R-BTA-72649); (R-BTA-72689); (R-BTA-72695); (R-BTA-72702)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003743 translation initiation factor activity;GO:0003729 mRNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0016282 eukaryotic 43S preinitiation complex;GO:0033290 eukaryotic 48S preinitiation complex;GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m", "go_biological_process": "GO:0075522 IRES-dependent viral translational initiation;GO:0001732 formation of cytoplasmic translation initiation complex;GO:0075525 viral translational termination-reinitiation;GO:0002188 translation reinitiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9S6A7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9S900-1", "uniprot_id": [ { "id": "A0AAA9S900_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9S900", "type": "external" } ], "mass": 40192.0, "length": 379, "protein_name": "Ribokinase", "gene_name": "RBKS", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RBKS", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribokinase; 2.7.1.15; RK", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-71336)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.15", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0004747 ribokinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006098 pentose-phosphate shunt;GO:0019303 D-ribose catabolic process;GO:0006753 nucleoside phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9S900-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNJ5-1", "uniprot_id": [ { "id": "MYL1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNJ5", "type": "external" } ], "mass": 20932.0, "length": 192, "protein_name": "Myosin light chain 1/3, skeletal muscle isoform", "gene_name": "MYL1", "organism": "Bovine", "refseq_name": "myosin light chain 1/3, skeletal muscle isoform", "refseq_ac": [ { "id": "NP_001073046", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073046", "type": "external" } ], "gene_names_uniprotkb": "MYL1", "gene_names_refseq": "MYL1", "protein_names_uniprotkb": "Myosin light chain 1/3, skeletal muscle isoform; MLC1/MLC3; MLC1F/MLC3F; Myosin light chain A1/A2; Myosin light chain alkali 1/2", "protein_names_refseq": "A1 catalytic; MLC1/MLC3; MLC1F/MLC3F; MLC1F; alkali myosin light chain 1; myosin light chain 1/3, skeletal muscle isoform; myosin light chain A1/A2; myosin light chain alkali 1/2; myosin, light chain 1, alkali; myosin, light polypeptide 1, alkali; skeletal, fast", "tax_id": 9913, "disease": "", "pathway": " (bta:317657); (R-BTA-390522)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "7762638", "class_list": "", "function": "Non-regulatory myosin light chain required for proper formation and/or maintenance of myofibers, and thus appropriate muscle function., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q29436", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008307 structural constituent of muscle;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0030016 myofibril;GO:0043292 contractile muscle fiber;GO:0016460 myosin II complex;GO:0016459 myosin complex", "go_biological_process": "GO:0006936 muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0JNJ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9SU81-1", "uniprot_id": [ { "id": "A0AAA9SU81_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9SU81", "type": "external" } ], "mass": 62321.0, "length": 552, "protein_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "gene_name": "PRKAA2", "organism": "Bovine", "refseq_name": "5'-AMP-activated protein kinase catalytic subunit alpha-2", "refseq_ac": [ { "id": "NP_001192534", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192534", "type": "external" } ], "gene_names_uniprotkb": "PRKAA2", "gene_names_refseq": "PRKAA2", "protein_names_uniprotkb": "5'-AMP-activated protein kinase catalytic subunit alpha-2; 2.7.11.1; 2.7.11.31; Acetyl-CoA carboxylase kinase; Hydroxymethylglutaryl-CoA reductase kinase", "protein_names_refseq": "5'-AMP-activated protein kinase catalytic subunit alpha-2; AMPK-activated protein kinase alpha-2 subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:538954); (R-BTA-1632852); (R-BTA-163680); (R-BTA-200425); (R-BTA-380972); (R-BTA-5628897); (R-BTA-6804756); (R-BTA-9759194); (R-BTA-9931269)", "pathway_count": 9, "publication_count": 3, "publication_id_list": "17290417;20842448;26974839", "class_list": "", "function": "Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK). Publication Status: Online-Only, [RefSeq, PubMed]; The investigation of PRKAA2 genetic polymorphisms in three Chinese indigenous bovine breeds [Qinchuan (n = 328), Nanyang (n = 278), Jiaxian (n = 148)] and yak (n = 57), is reported., [RefSeq, PubMed]; These data show that the AMPK activator AICAR is inhibitory to nuclear maturation in bovine oocytes due to activation of AMPK [AMP-activated protein kinase alpha 1 subunit]., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "6.4.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.4.1.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004679 AMP-activated protein kinase activity;GO:0047322 [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0120025 plasma membrane bounded cell projection;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006633 fatty acid biosynthetic process;GO:0006695 cholesterol biosynthetic process;GO:0006914 autophagy;GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A0AAA9SU81-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN87-1", "uniprot_id": [ { "id": "ODC_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JN87", "type": "external" } ], "mass": 33108.0, "length": 299, "protein_name": "Mitochondrial 2-oxodicarboxylate carrier", "gene_name": "SLC25A21", "organism": "Bovine", "refseq_name": "mitochondrial 2-oxodicarboxylate carrier isoform X2", "refseq_ac": [ { "id": "XP_005222099", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005222099", "type": "external" } ], "gene_names_uniprotkb": "SLC25A21; ODC", "gene_names_refseq": "SLC25A21", "protein_names_uniprotkb": "Mitochondrial 2-oxodicarboxylate carrier; Solute carrier family 25 member 21", "protein_names_refseq": "mitochondrial 2-oxodicarboxylate carrier isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-71064)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transports dicarboxylates across the inner membranes of mitochondria by a counter-exchange mechanism. Can transport 2-oxoadipate (2-oxohexanedioate), 2-oxoglutarate, adipate (hexanedioate), glutarate, and to a lesser extent, pimelate (heptanedioate), 2-oxopimelate (2-oxoheptanedioate), 2-aminoadipate (2-aminohexanedioate), oxaloacetate, and citrate. Plays a central role in catabolism of lysine, hydroxylysine, and tryptophan, by transporting common metabolite intermediates (such as 2-oxoadipate) into the mitochondria, where it is converted into acetyl-CoA and can enter the citric acid (TCA) cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0015139 alpha-ketoglutarate transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0006869 lipid transport;GO:1990550 mitochondrial alpha-ketoglutarate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JN87-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JND3-1", "uniprot_id": [ { "id": "EOGT_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JND3", "type": "external" } ], "mass": 61749.0, "length": 527, "protein_name": "EGF domain-specific O-linked N-acetylglucosamine transferase", "gene_name": "EOGT", "organism": "Bovine", "refseq_name": "EGF domain-specific O-linked N-acetylglucosamine transferase precursor", "refseq_ac": [ { "id": "NP_001071350", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071350", "type": "external" } ], "gene_names_uniprotkb": "EOGT; AER61", "gene_names_refseq": "AER61; C22H3orf64; EOGT", "protein_names_uniprotkb": "EGF domain-specific O-linked N-acetylglucosamine transferase; 2.4.1.255; Extracellular O-linked N-acetylglucosamine transferase", "protein_names_refseq": "AER61 glycosyltransferase; EGF domain-specific O-linked N-acetylglucosamine transferase precursor; extracellular O-linked N-acetylglucosamine transferase", "tax_id": 9913, "disease": "", "pathway": " (bta:508782)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.255", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.255", "type": "external" } ], "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0006493 protein O-linked glycosylation", "synthesized_glycan_count": 5, "hit_score": 0.1, "record_id": "A0JND3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9T4J2-1", "uniprot_id": [ { "id": "A0AAA9T4J2_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9T4J2", "type": "external" } ], "mass": 50034.0, "length": 467, "protein_name": "Adenylyltransferase and sulfurtransferase MOCS3", "gene_name": "MOCS3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MOCS3; UBA4", "gene_names_refseq": "", "protein_names_uniprotkb": "Adenylyltransferase and sulfurtransferase MOCS3; Adenylyltransferase MOCS3; Molybdenum cofactor synthesis protein 3; Sulfur carrier protein MOCS2A adenylyltransferase; Sulfur carrier protein MOCS2A sulfurtransferase; Sulfurtransferase MOCS3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.80", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.80", "type": "external" }, { "id": "2.8.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.11", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0042292 URM1 activating enzyme activity;GO:0061604 molybdopterin-synthase sulfurtransferase activity;GO:0061605 molybdopterin-synthase adenylyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0006777 Mo-molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9T4J2-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN95-1", "uniprot_id": [ { "id": "MET15_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JN95", "type": "external" } ], "mass": 45768.0, "length": 407, "protein_name": "12S rRNA N(4)-cytidine methyltransferase METTL15", "gene_name": "METTL15", "organism": "Bovine", "refseq_name": "12S rRNA N(4)-cytidine methyltransferase METTL15", "refseq_ac": [ { "id": "NP_001073250", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073250", "type": "external" } ], "gene_names_uniprotkb": "METTL15; METT5D1", "gene_names_refseq": "METT5D1; METTL15", "protein_names_uniprotkb": "12S rRNA N(4)-cytidine methyltransferase METTL15; 12S rRNA m4C methyltransferase; 2.1.1.-; Methyltransferase 5 domain-containing protein 1; Methyltransferase-like protein 15", "protein_names_refseq": "12S rRNA N(4)-cytidine methyltransferase METTL15; 12S rRNA N4-methylcytidine methyltransferase; 12S rRNA m4C methyltransferase; methyltransferase 5 domain containing 1; methyltransferase 5 domain-containing protein 1; probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1; probable methyltransferase-like protein 15; putative S-adenosyl-L-methionine-dependent methyltransferase METT5D1", "tax_id": 9913, "disease": "", "pathway": " (bta:533987)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA. Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity;GO:0008168 methyltransferase activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0070475 rRNA base methylation;GO:0180026 mitochondrial small ribosomal subunit assembly;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JN95-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9T8F6-1", "uniprot_id": [ { "id": "A0AAA9T8F6_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9T8F6", "type": "external" } ], "mass": 39708.0, "length": 353, "protein_name": "Ubiquinone biosynthesis O-methyltransferase, mitochondrial", "gene_name": "COQ3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "COQ3", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquinone biosynthesis O-methyltransferase, mitochondrial; 2.1.1.-; 2.1.1.114; 2.1.1.64; 3-demethylubiquinol 3-O-methyltransferase; 3-demethylubiquinone 3-O-methyltransferase; Polyprenyldihydroxybenzoate methyltransferase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2142789)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "O-methyltransferase required for two non-consecutive steps during ubiquinone biosynthesis. Catalyzes the 2 O-methylation of 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid into 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid. Also catalyzes the last step of ubiquinone biosynthesis by mediating methylation of 3-demethylubiquinone into ubiquinone. Also able to mediate the methylation of 3-demethylubiquinol-10 into ubiquinol-10., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.1.1.114", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.114", "type": "external" }, { "id": "2.1.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.64", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0010420 polyprenyldihydroxybenzoate methyltransferase activity;GO:0061542 3-demethylubiquinol 3-O-methyltransferase activity;GO:0120537 3-demethylubiquinone 3-O-methyltransferase activity", "go_cellular_component": "GO:0031314 extrinsic component of mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0005739 mitochondrion", "go_biological_process": "GO:0006071 glycerol metabolic process;GO:0032259 methylation;GO:0006744 ubiquinone biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9T8F6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9TBC9-1", "uniprot_id": [ { "id": "A0AAA9TBC9_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9TBC9", "type": "external" } ], "mass": 22804.0, "length": 203, "protein_name": "Leukotriene C4 synthase", "gene_name": "LTC4S", "organism": "Bovine", "refseq_name": "leukotriene C4 synthase isoform X1", "refseq_ac": [ { "id": "XP_059744065", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744065", "type": "external" } ], "gene_names_uniprotkb": "LTC4S", "gene_names_refseq": "LTC4S", "protein_names_uniprotkb": "Leukotriene C4 synthase; 2.5.1.-; 4.4.1.20; Leukotriene-C(4) synthase", "protein_names_refseq": "leukotriene C4 synthase isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity. Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.4.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20", "type": "external" }, { "id": "2.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" }, { "id": "2.5.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18", "type": "external" } ], "go_molecular_function": "GO:0004464 leukotriene-C4 synthase activity;GO:0008047 enzyme activator activity;GO:0042802 identical protein binding;GO:0008289 lipid binding;GO:0016740 transferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005640 nuclear outer membrane;GO:0031965 nuclear membrane", "go_biological_process": "GO:0019370 leukotriene biosynthetic process;GO:0042759 long-chain fatty acid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9TBC9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9TBH1-1", "uniprot_id": [ { "id": "A0AAA9TBH1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9TBH1", "type": "external" } ], "mass": 45116.0, "length": 408, "protein_name": "Enolase-phosphatase E1", "gene_name": "ENOPH1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ENOPH1; MASA", "gene_names_refseq": "", "protein_names_uniprotkb": "Enolase-phosphatase E1; 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; 3.1.3.77; MASA homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene)., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.77", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.77", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0043874 acireductone synthase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0019509 L-methionine salvage from methylthioadenosine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9TBH1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN92-1", "uniprot_id": [ { "id": "URGCP_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JN92", "type": "external" } ], "mass": 104872.0, "length": 922, "protein_name": "Up-regulator of cell proliferation", "gene_name": "URGCP", "organism": "Bovine", "refseq_name": "up-regulator of cell proliferation", "refseq_ac": [ { "id": "NP_001015513", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001015513", "type": "external" } ], "gene_names_uniprotkb": "URGCP; URG4", "gene_names_refseq": "URG4; URGCP", "protein_names_uniprotkb": "Up-regulator of cell proliferation; HBV X protein up-regulated gene 4 protein homolog; HBxAg up-regulated gene 4 protein homolog", "protein_names_refseq": "HBV X protein up-regulated gene 4 protein homolog; HBxAg up-regulated gene 4 protein homolog; Protein URG4; up-regulated gene 4; up-regulator of cell proliferation", "tax_id": 9913, "disease": "", "pathway": " (bta:504226)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "May be involved in cell cycle progression through the regulation of cyclin D1 expression., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58DE0", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0JN92-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9TRB1-1", "uniprot_id": [ { "id": "A0AAA9TRB1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9TRB1", "type": "external" } ], "mass": 52445.0, "length": 468, "protein_name": "Mitochondrial adenyl nucleotide antiporter SLC25A23", "gene_name": "SLC25A23", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC25A23", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial adenyl nucleotide antiporter SLC25A23; Short calcium-binding mitochondrial carrier protein 3; Solute carrier family 25 member 23", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Electroneutral antiporter that mediates the transport of adenine nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenine nucleotide pool could adapt to changing cellular energetic demands and indirectly regulate adenine nucleotide-dependent metabolic pathways. Also acts as a regulator of mitochondrial calcium uptake and can probably transport trace amounts of other divalent metal cations in complex with ATP. In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0015297 antiporter activity;GO:0005347 ATP transmembrane transporter activity;GO:0140987 ATP:phosphate antiporter activity;GO:0140988 ADP:phosphate antiporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0051503 adenine nucleotide transport;GO:0055085 transmembrane transport;GO:0015866 ADP transport;GO:0036444 calcium import into the mitochondrion;GO:0051561 positive regulation of mitochondrial calcium ion concentration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9TRB1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9TVM7-1", "uniprot_id": [ { "id": "A0AAA9TVM7_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9TVM7", "type": "external" } ], "mass": 51175.0, "length": 460, "protein_name": "Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3", "gene_name": "SLC46A3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC46A3", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3; Solute carrier family 46 member 3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0005375 copper ion transmembrane transporter activity", "go_cellular_component": "GO:0005765 lysosomal membrane", "go_biological_process": "GO:1904613 cellular response to 2,3,7,8-tetrachlorodibenzodioxine;GO:0034486 vacuolar transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9TVM7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAF6DLT4-1", "uniprot_id": [ { "id": "A0AAF6DLT4_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAF6DLT4", "type": "external" } ], "mass": 39302.0, "length": 342, "protein_name": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1", "gene_name": "ST3GAL1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ST3GAL1", "gene_names_refseq": "", "protein_names_uniprotkb": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1; 2.4.3.2; 2.4.3.4; Gal-NAc6S; Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; Monosialoganglioside sialyltransferase; ST3Gal I; ST3GalA.1; ST3O; Sialyltransferase 4A", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.2", "type": "external" }, { "id": "2.4.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.4", "type": "external" }, { "id": "2.4.3.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.6", "type": "external" } ], "go_molecular_function": "GO:0047288 beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase;GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0032588 trans-Golgi network membrane;GO:1990675 Golgi medial cisterna membrane;GO:1990676 Golgi trans cisterna membrane", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process;GO:1905403 negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process;GO:0097503 sialylation;GO:0001574 ganglioside biosynthetic process;GO:0002319 memory B cell differentiation", "synthesized_glycan_count": 881, "hit_score": 0.1, "record_id": "A0AAF6DLT4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN40-1", "uniprot_id": [ { "id": "KIF3C_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JN40", "type": "external" } ], "mass": 89487.0, "length": 792, "protein_name": "Kinesin-like protein KIF3C", "gene_name": "KIF3C", "organism": "Bovine", "refseq_name": "kinesin-like protein KIF3C", "refseq_ac": [ { "id": "NP_001071623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071623", "type": "external" } ], "gene_names_uniprotkb": "KIF3C", "gene_names_refseq": "KIF3C", "protein_names_uniprotkb": "Kinesin-like protein KIF3C", "protein_names_refseq": "kinesin-like protein KIF3C", "tax_id": 9913, "disease": "", "pathway": " (bta:777770)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Microtubule-based anterograde translocator for membranous organelles., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0008574 plus-end-directed microtubule motor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005876 spindle microtubule;GO:0072686 mitotic spindle", "go_biological_process": "GO:0090307 mitotic spindle assembly;GO:0007018 microtubule-based movement;GO:0051231 spindle elongation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JN40-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN51-1", "uniprot_id": [ { "id": "ELF1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JN51", "type": "external" } ], "mass": 66572.0, "length": 614, "protein_name": "ETS-related transcription factor Elf-1", "gene_name": "ELF1", "organism": "Bovine", "refseq_name": "ETS-related transcription factor Elf-1", "refseq_ac": [ { "id": "NP_001071321", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071321", "type": "external" } ], "gene_names_uniprotkb": "ELF1", "gene_names_refseq": "ELF1", "protein_names_uniprotkb": "ETS-related transcription factor Elf-1; E74-like factor 1", "protein_names_refseq": "E74-like factor 1 (ets domain transcription factor); ETS-related transcription factor Elf-1", "tax_id": 9913, "disease": "", "pathway": " (bta:505251); (R-BTA-8939247)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "26495903", "class_list": "", "function": "Transcription factor that activates the LYN and BLK promoters., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0JN51-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN61-1", "uniprot_id": [ { "id": "RPC9_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JN61", "type": "external" } ], "mass": 16745.0, "length": 148, "protein_name": "DNA-directed RNA polymerase III subunit RPC9", "gene_name": "CRCP", "organism": "Bovine", "refseq_name": "DNA-directed RNA polymerase III subunit RPC9", "refseq_ac": [ { "id": "NP_001071338", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071338", "type": "external" } ], "gene_names_uniprotkb": "CRCP", "gene_names_refseq": "CRCP; RCP9", "protein_names_uniprotkb": "DNA-directed RNA polymerase III subunit RPC9; RNA polymerase III subunit C9", "protein_names_refseq": "DNA-directed RNA polymerase III subunit RPC9; RNA polymerase III subunit C9; calcitonin gene-related peptide-receptor component protein", "tax_id": 9913, "disease": "", "pathway": " (bta:507533); (R-BTA-76061); (R-BTA-76066); (R-BTA-76071)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues., [UniProtKB, UniProtKB]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (By similarity). With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding;GO:0003899 DNA-directed RNA polymerase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009360 DNA polymerase III complex;GO:0005666 RNA polymerase III complex", "go_biological_process": "GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0006383 transcription by RNA polymerase III;GO:0006384 transcription initiation at RNA polymerase III promoter", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JN61-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JN80-1", "uniprot_id": [ { "id": "DI3L1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JN80", "type": "external" } ], "mass": 120594.0, "length": 1053, "protein_name": "DIS3-like exonuclease 1", "gene_name": "DIS3L", "organism": "Bovine", "refseq_name": "DIS3-like exonuclease 1", "refseq_ac": [ { "id": "NP_001071624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071624", "type": "external" } ], "gene_names_uniprotkb": "DIS3L", "gene_names_refseq": "DIS3L", "protein_names_uniprotkb": "DIS3-like exonuclease 1; 3.1.13.1", "protein_names_refseq": "DIS3 mitotic control homolog-like; DIS3-like exonuclease 1", "tax_id": 9913, "disease": "", "pathway": " (bta:777771)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008859 exoribonuclease II activity;GO:0003723 RNA binding;GO:0019899 enzyme binding;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0000177 cytoplasmic exosome (RNase complex)", "go_biological_process": "GO:0006402 mRNA catabolic process;GO:0016075 rRNA catabolic process;GO:0010467 gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JN80-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNA2-1", "uniprot_id": [ { "id": "SEZ6_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNA2", "type": "external" } ], "mass": 105923.0, "length": 983, "protein_name": "Seizure protein 6 homolog", "gene_name": "SEZ6", "organism": "Bovine", "refseq_name": "seizure protein 6 homolog precursor", "refseq_ac": [ { "id": "NP_001071486", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071486", "type": "external" } ], "gene_names_uniprotkb": "SEZ6", "gene_names_refseq": "SEZ6", "protein_names_uniprotkb": "Seizure protein 6 homolog; SEZ-6", "protein_names_refseq": "SEZ-6; Seizure protein 6 homolog; seizure protein 6 homolog precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:539038)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity)., [UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 4, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043025 neuronal cell body;GO:0043197 dendritic spine;GO:0043198 dendritic shaft", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:0021680 cerebellar Purkinje cell layer development;GO:0060074 synapse maturation;GO:0050773 regulation of dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNA2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNB3-1", "uniprot_id": [ { "id": "LY6H_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNB3", "type": "external" } ], "mass": 14813.0, "length": 140, "protein_name": "Lymphocyte antigen 6H", "gene_name": "LY6H", "organism": "Bovine", "refseq_name": "lymphocyte antigen 6H precursor", "refseq_ac": [ { "id": "NP_001073104", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073104", "type": "external" } ], "gene_names_uniprotkb": "LY6H", "gene_names_refseq": "LY6H", "protein_names_uniprotkb": "Lymphocyte antigen 6H; Ly-6H", "protein_names_refseq": "ly-6H; lymphocyte antigen 6 complex, locus H; lymphocyte antigen 6H precursor; lymphocyte antigen 6H", "tax_id": 9913, "disease": "", "pathway": " (bta:618749)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0030550 acetylcholine receptor inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0098552 side of membrane", "go_biological_process": "GO:0095500 acetylcholine receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNB3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNC0-1", "uniprot_id": [ { "id": "TMOD1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNC0", "type": "external" } ], "mass": 40459.0, "length": 359, "protein_name": "Tropomodulin-1", "gene_name": "TMOD1", "organism": "Bovine", "refseq_name": "tropomodulin-1", "refseq_ac": [ { "id": "NP_001073108", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073108", "type": "external" } ], "gene_names_uniprotkb": "TMOD1", "gene_names_refseq": "TMOD1", "protein_names_uniprotkb": "Tropomodulin-1; E-Tmod; Erythrocyte tropomodulin", "protein_names_refseq": "E-Tmod; erythrocyte tropomodulin; tropomodulin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:780784); (R-BTA-390522)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005523 tropomyosin binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0016020 membrane;GO:0005865 striated muscle thin filament;GO:0030017 sarcomere", "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0051694 pointed-end actin filament capping;GO:0070307 lens fiber cell development;GO:0030239 myofibril assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNC0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNC3-1", "uniprot_id": [ { "id": "INSI1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNC3", "type": "external" } ], "mass": 29608.0, "length": 276, "protein_name": "Insulin-induced gene 1 protein", "gene_name": "INSIG1", "organism": "Bovine", "refseq_name": "insulin-induced gene 1 protein", "refseq_ac": [ { "id": "NP_001071377", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071377", "type": "external" } ], "gene_names_uniprotkb": "INSIG1", "gene_names_refseq": "INSIG1", "protein_names_uniprotkb": "Insulin-induced gene 1 protein; INSIG-1", "protein_names_refseq": "INSIG-1; insulin induced protein 1; insulin-induced gene 1 protein", "tax_id": 9913, "disease": "", "pathway": " (bta:511899)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22642648", "class_list": "", "function": "In Nanyang Chinese cattle, seven common haplotypes were identified in the INSIG1 gene based on four coding region SNPs., [RefSeq, PubMed]; Oxysterol-binding protein that mediates feedback control of cholesterol synthesis by controlling both endoplasmic reticulum to Golgi transport of SCAP and degradation of HMGCR. Acts as a negative regulator of cholesterol biosynthesis by mediating the retention of the SCAP-SREBP complex in the endoplasmic reticulum, thereby blocking the processing of sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2. Binds oxysterol, including 25-hydroxycholesterol, regulating interaction with SCAP and retention of the SCAP-SREBP complex in the endoplasmic reticulum. In presence of oxysterol, interacts with SCAP, retaining the SCAP-SREBP complex in the endoplasmic reticulum, thereby preventing SCAP from escorting SREBF1/SREBP1 and SREBF2/SREBP2 to the Golgi. Sterol deprivation or phosphorylation by PCK1 reduce oxysterol-binding, disrupting the interaction between INSIG1 and SCAP, thereby promoting Golgi transport of the SCAP-SREBP complex, followed by processing and nuclear translocation of SREBF1/SREBP1 and SREBF2/SREBP2. Also regulates cholesterol synthesis by regulating degradation of HMGCR: initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligases AMFR/gp78 and/or RNF139. Also regulates degradation of SOAT2/ACAT2 when the lipid levels are low: initiates the ubiquitin-mediated degradation of SOAT2/ACAT2 via recruitment of the ubiquitin ligases AMFR/gp78., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008142 oxysterol binding", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0032937 SREBP-SCAP-Insig complex", "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0006695 cholesterol biosynthetic process;GO:0032933 SREBP signaling pathway;GO:0036316 SREBP-SCAP complex retention in endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A0JNC3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JND2-1", "uniprot_id": [ { "id": "K2C80_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JND2", "type": "external" } ], "mass": 47438.0, "length": 422, "protein_name": "Keratin, type II cytoskeletal 80", "gene_name": "KRT80", "organism": "Bovine", "refseq_name": "keratin, type II cytoskeletal 80", "refseq_ac": [ { "id": "NP_001071420", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071420", "type": "external" } ], "gene_names_uniprotkb": "KRT80", "gene_names_refseq": "KRT80", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 80; CK-80; Cytokeratin-80; K80; Keratin-80; Type-II keratin Kb20", "protein_names_refseq": "CK-80; K80; cytokeratin-80; keratin, type II cytoskeletal 80; type-II keratin Kb20", "tax_id": 9913, "disease": "", "pathway": " (bta:522400); (R-BTA-6805567); (R-BTA-6809371)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JND2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JND9-1", "uniprot_id": [ { "id": "ENTP8_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JND9", "type": "external" } ], "mass": 53240.0, "length": 495, "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 8", "gene_name": "ENTPD8", "organism": "Bovine", "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 8", "refseq_ac": [ { "id": "NP_001071395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071395", "type": "external" } ], "gene_names_uniprotkb": "ENTPD8", "gene_names_refseq": "ENTPD8", "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 8; 3.6.1.5; E-NTPDase 8; NTPDase 8; NTPDase8", "protein_names_refseq": "E-NTPDase 8; NTPDase 8; NTPDase8; ectonucleoside triphosphate diphosphohydrolase 8", "tax_id": 9913, "disease": "", "pathway": " (bta:515532)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates. This activity contributes to the regulation of extracellular levels of nucleotides. Hydrolyzes ATP, UTP, ADP, and UDP and prefers triphosphonucleosides and adenine over uracil as substrates. Does not hydrolyzes AMP., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.6.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.16", "type": "external" }, { "id": "3.6.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.53", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity;GO:0004382 GDP phosphatase activity;GO:0043262 ADP phosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0009134 nucleoside diphosphate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JND9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNE3-1", "uniprot_id": [ { "id": "NR2C1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNE3", "type": "external" } ], "mass": 67714.0, "length": 608, "protein_name": "Nuclear receptor subfamily 2 group C member 1", "gene_name": "NR2C1", "organism": "Bovine", "refseq_name": "nuclear receptor subfamily 2 group C member 1", "refseq_ac": [ { "id": "NP_001071372", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071372", "type": "external" } ], "gene_names_uniprotkb": "NR2C1", "gene_names_refseq": "NR2C1", "protein_names_uniprotkb": "Nuclear receptor subfamily 2 group C member 1", "protein_names_refseq": "nuclear receptor subfamily 2 group C member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:511407)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity). Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0004879 nuclear receptor activity", "go_cellular_component": "GO:0016605 PML body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNE3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNI9-1", "uniprot_id": [ { "id": "S7A14_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNI9", "type": "external" } ], "mass": 84188.0, "length": 771, "protein_name": "Solute carrier family 7 member 14", "gene_name": "SLC7A14", "organism": "Bovine", "refseq_name": "solute carrier family 7 member 14", "refseq_ac": [ { "id": "NP_001071460", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071460", "type": "external" } ], "gene_names_uniprotkb": "SLC7A14", "gene_names_refseq": "SLC7A14", "protein_names_uniprotkb": "Solute carrier family 7 member 14; Gamma-aminobutyric acid transporter SLC7A14", "protein_names_refseq": "gamma-aminobutyric acid transporter SLC7A14; probable cationic amino acid transporter; solute carrier family 7 (cationic amino acid transporter, y+ system), member 14; solute carrier family 7 (orphan transporter), member 14; solute carrier family 7 member 14", "tax_id": 9913, "disease": "", "pathway": " (bta:533046)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Imports 4-aminobutanoate (GABA) into lysosomes. May act as a GABA sensor that regulates mTORC2-dependent INS signaling and gluconeogenesis. The transport mechanism and substrate selectivity remain to be elucidated., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015171 amino acid transmembrane transporter activity;GO:0015185 gamma-aminobutyric acid transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane", "go_biological_process": "GO:0006865 amino acid transport;GO:0051939 gamma-aminobutyric acid import", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNI9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNJ1-1", "uniprot_id": [ { "id": "STAC_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNJ1", "type": "external" } ], "mass": 44487.0, "length": 403, "protein_name": "SH3 and cysteine-rich domain-containing protein", "gene_name": "STAC", "organism": "Bovine", "refseq_name": "SH3 and cysteine-rich domain-containing protein", "refseq_ac": [ { "id": "NP_001071430", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071430", "type": "external" } ], "gene_names_uniprotkb": "STAC", "gene_names_refseq": "STAC", "protein_names_uniprotkb": "SH3 and cysteine-rich domain-containing protein; Src homology 3 and cysteine-rich domain-containing protein", "protein_names_refseq": "SH3 and cysteine-rich domain-containing protein; SRC homology 3 and cysteine-rich domain protein; SRC homology 3 and cysteine-rich domain-containing protein", "tax_id": 9913, "disease": "", "pathway": " (bta:524215)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0044325 transmembrane transporter binding", "go_cellular_component": "GO:0005829 cytosol;GO:0042383 sarcolemma;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:1903078 positive regulation of protein localization to plasma membrane;GO:2001259 positive regulation of cation channel activity;GO:1901387 positive regulation of voltage-gated calcium channel activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNJ1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNM6-1", "uniprot_id": [ { "id": "LYZL1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNM6", "type": "external" } ], "mass": 16779.0, "length": 148, "protein_name": "Lysozyme-like protein 1", "gene_name": "LYZL1", "organism": "Bovine", "refseq_name": "lysozyme-like protein 1 precursor", "refseq_ac": [ { "id": "NP_001071378", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071378", "type": "external" } ], "gene_names_uniprotkb": "LYZL1", "gene_names_refseq": "LYZL1; LYZL2", "protein_names_uniprotkb": "Lysozyme-like protein 1; 3.2.1.17", "protein_names_refseq": "lysozyme-like 2; lysozyme-like protein 1 precursor; lysozyme-like protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:512087)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosylhydrolase", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNM6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.10100", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNN3-1", "uniprot_id": [ { "id": "MED31_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNN3", "type": "external" } ], "mass": 15789.0, "length": 131, "protein_name": "Mediator of RNA polymerase II transcription subunit 31", "gene_name": "MED31", "organism": "Bovine", "refseq_name": "mediator of RNA polymerase II transcription subunit 31", "refseq_ac": [ { "id": "NP_001071457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071457", "type": "external" } ], "gene_names_uniprotkb": "MED31; SOH1", "gene_names_refseq": "MED31", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 31; Mediator complex subunit 31; Mediator complex subunit SOH1", "protein_names_refseq": "mediator complex subunit SOH1; mediator of RNA polymerase II transcription subunit 31", "tax_id": 9913, "disease": "", "pathway": " (bta:532868); (R-BTA-212436); (R-BTA-9841922)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNN3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNQ6-1", "uniprot_id": [ { "id": "OOEP_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNQ6", "type": "external" } ], "mass": 15868.0, "length": 140, "protein_name": "Oocyte-expressed protein homolog", "gene_name": "OOEP", "organism": "Bovine", "refseq_name": "oocyte-expressed protein homolog", "refseq_ac": [ { "id": "NP_001071337", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071337", "type": "external" } ], "gene_names_uniprotkb": "OOEP", "gene_names_refseq": "OOEP", "protein_names_uniprotkb": "Oocyte-expressed protein homolog", "protein_names_refseq": "oocyte expressed protein homolog (dog); oocyte-expressed protein homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:507401)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. As part of the OOEP-KHDC3 scaffold, recruits BLM and TRIM25 to DNA replication forks, thereby promoting the ubiquitination of BLM by TRIM25, enhancing BLM retainment at replication forks and therefore promoting stalled replication fork restart. Positively regulates the homologous recombination-mediated DNA double-strand break (DSB) repair pathway by regulating ATM activation and RAD51 recruitment to DSBs in oocytes. Thereby contributes to oocyte survival and the resumption and completion of meiosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0140094 structural constituent of cytoplasmic lattice", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005938 cell cortex;GO:0032991 protein-containing complex;GO:0140095 cytoplasmic lattice", "go_biological_process": "GO:0045836 positive regulation of meiotic nuclear division;GO:0051293 establishment of spindle localization;GO:0007015 actin filament organization;GO:0032880 regulation of protein localization;GO:2000781 positive regulation of double-strand break repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNQ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0AAA9SJL9-1", "uniprot_id": [ { "id": "A0AAA9SJL9_BOVIN", "url": "https://www.uniprot.org/uniprot/A0AAA9SJL9", "type": "external" } ], "mass": 108327.0, "length": 971, "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "PARP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PARP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase; 2.4.2.30", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-110362); (R-BTA-2173795); (R-BTA-3108214); (R-BTA-5685939); (R-BTA-5696394); (R-BTA-5696395); (R-BTA-5696400)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair., [UniProtKB, UniProtKB, UniProtKB]; Promotes AIFM1-mediated apoptosis. This form, which translocates into the cytoplasm following cleavage by caspase-3 (CASP3) and caspase-7 (CASP7) in response to apoptosis, is auto-poly-ADP-ribosylated and serves as a poly-ADP-ribose carrier to induce AIFM1-mediated apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "3.1.11.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2", "type": "external" }, { "id": "3.1.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.2.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.143", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0051287 NAD binding", "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005635 nuclear envelope;GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "GO:0070213 protein auto-ADP-ribosylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0032869 cellular response to insulin stimulus;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0AAA9SJL9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFD2-1", "uniprot_id": [ { "id": "FOXP1_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFD2", "type": "external" } ], "mass": 75121.0, "length": 674, "protein_name": "Forkhead box protein P1", "gene_name": "FOXP1", "organism": "Bovine", "refseq_name": "forkhead box protein P1", "refseq_ac": [ { "id": "NP_001077158", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077158", "type": "external" } ], "gene_names_uniprotkb": "FOXP1", "gene_names_refseq": "FOXP1", "protein_names_uniprotkb": "Forkhead box protein P1", "protein_names_refseq": "forkhead box protein P1", "tax_id": 9913, "disease": "", "pathway": " (bta:515903)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal cord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18. Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis. Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor. Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B. Can negatively regulate androgen receptor signaling (By similarity). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045892 negative regulation of DNA-templated transcription;GO:0048513 animal organ development;GO:0032651 regulation of interleukin-1 beta production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFD2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLR4-1", "uniprot_id": [ { "id": "FLOT2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLR4", "type": "external" } ], "mass": 46995.0, "length": 428, "protein_name": "Flotillin-2", "gene_name": "FLOT2", "organism": "Bovine", "refseq_name": "flotillin-2", "refseq_ac": [ { "id": "NP_001030543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030543", "type": "external" } ], "gene_names_uniprotkb": "FLOT2", "gene_names_refseq": "FLOT2", "protein_names_uniprotkb": "Flotillin-2", "protein_names_refseq": "flotillin-2", "tax_id": 9913, "disease": "", "pathway": " (bta:615679); (R-BTA-5213460); (R-BTA-5675482); (R-BTA-8849932); (R-BTA-8980692); (R-BTA-9013106); (R-BTA-9696264); (R-BTA-9696273)", "pathway_count": 8, "publication_count": 1, "publication_id_list": "30573663", "class_list": "", "function": "May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0002020 protease binding", "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle;GO:0030139 endocytic vesicle;GO:0016600 flotillin complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0072659 protein localization to plasma membrane;GO:0045661 regulation of myoblast differentiation;GO:0044860 protein localization to plasma membrane raft;GO:1903905 positive regulation of establishment of T cell polarity", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QLR4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H7A0-1", "uniprot_id": [ { "id": "FACE2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H7A0", "type": "external" } ], "mass": 33455.0, "length": 308, "protein_name": "CAAX prenyl protease 2", "gene_name": "RCE1; TOP6BL", "organism": "Bovine", "refseq_name": "CAAX prenyl protease 2", "refseq_ac": [ { "id": "NP_001092567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092567", "type": "external" } ], "gene_names_uniprotkb": "RCE1; TOP6BL; TOP6BL", "gene_names_refseq": "FACE-2; RCE1", "protein_names_uniprotkb": "CAAX prenyl protease 2; 3.4.26.1; FACE-2; Farnesylated proteins-converting enzyme 2; Prenyl protein-specific endoprotease 2; RCE1 homolog", "protein_names_refseq": "CAAX prenyl protease 2; CAAX prenyl protein protease RCE1; Farnesylated proteins-converting enzyme 2; Prenyl protein-specific endoprotease 2; RCE1 homolog, prenyl protein peptidase; RCE1 homolog, prenyl protein protease; prenyl protein peptidase RCE1", "tax_id": 9913, "disease": "", "pathway": " (bta:539539); (R-BTA-5689880); (R-BTA-9648002)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins, leaving the prenylated cysteine as the new C-terminus. Is able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "3.4.26.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.26.1", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" } ], "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071586 CAAX-box protein processing;GO:0042138 meiotic DNA double-strand break formation;GO:0080120 CAAX-box protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H7A0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNM2-1", "uniprot_id": [ { "id": "RRF2M_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNM2", "type": "external" } ], "mass": 86031.0, "length": 777, "protein_name": "Ribosome-releasing factor 2, mitochondrial", "gene_name": "GFM2", "organism": "Bovine", "refseq_name": "ribosome-releasing factor 2, mitochondrial", "refseq_ac": [ { "id": "NP_001095579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095579", "type": "external" } ], "gene_names_uniprotkb": "GFM2; EFG2", "gene_names_refseq": "EF-G2mt; GFM2; RRF2mt; mEF-G 2", "protein_names_uniprotkb": "Ribosome-releasing factor 2, mitochondrial; 3.6.5.-; EF-G2mt; Elongation factor G 2, mitochondrial; RRF2mt; mEF-G 2", "protein_names_refseq": "G elongation factor mitochondrial 2; elongation factor G 2, mitochondrial; mitochondrial elongation factor G2; ribosome-releasing factor 2, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:527467); (R-BTA-5419276)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "3.1.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.29", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0032790 ribosome disassembly;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QNM2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YWE4-1", "uniprot_id": [ { "id": "AL4A1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YWE4", "type": "external" } ], "mass": 61495.0, "length": 563, "protein_name": "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial", "gene_name": "ALDH4A1", "organism": "Bovine", "refseq_name": "delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001099116", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099116", "type": "external" } ], "gene_names_uniprotkb": "ALDH4A1", "gene_names_refseq": "ALDH4A1", "protein_names_uniprotkb": "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; 1.2.1.88; Aldehyde dehydrogenase family 4 member A1; L-glutamate gamma-semialdehyde dehydrogenase; P5C dehydrogenase", "protein_names_refseq": "Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial; L-glutamate gamma-semialdehyde dehydrogenase; P5C dehydrogenase; aldehyde dehydrogenase family 4 member A1; delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:100126042); (R-BTA-389661); (R-BTA-70688)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Irreversible conversion of delta-1-pyrroline-5-carboxylate (P5C), derived either from proline or ornithine, to glutamate. This is a necessary step in the pathway interconnecting the urea and tricarboxylic acid cycles. The preferred substrate is glutamic gamma-semialdehyde, other substrates include succinic, glutaric and adipic semialdehydes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.2.1.88", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.88", "type": "external" } ], "go_molecular_function": "GO:0003842 L-glutamate gamma-semialdehyde dehydrogenase activity;GO:0042802 identical protein binding;GO:0004029 aldehyde dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0010133 L-proline catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YWE4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4J7-1", "uniprot_id": [ { "id": "SMG8_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4J7", "type": "external" } ], "mass": 110135.0, "length": 999, "protein_name": "Nonsense-mediated mRNA decay factor SMG8", "gene_name": "GDPD1; SMG8", "organism": "Bovine", "refseq_name": "nonsense-mediated mRNA decay factor SMG8", "refseq_ac": [ { "id": "NP_001073755", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073755", "type": "external" } ], "gene_names_uniprotkb": "GDPD1; SMG8; GDPD1", "gene_names_refseq": "C19H17orf71; SMG8", "protein_names_uniprotkb": "Nonsense-mediated mRNA decay factor SMG8; Protein smg-8 homolog", "protein_names_refseq": "nonsense-mediated mRNA decay factor SMG8; protein SMG8; protein smg-8 homolog; smg-8 homolog, nonsense mediated mRNA decay factor", "tax_id": 9913, "disease": "", "pathway": " (bta:522040); (R-BTA-975957)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.54", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.54", "type": "external" }, { "id": "3.1.4.39", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.39", "type": "external" }, { "id": "3.1.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.44", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.44", "type": "external" } ], "go_molecular_function": "GO:0008081 phosphoric diester hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045859 regulation of protein kinase activity;GO:0006629 lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4J7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QR46-1", "uniprot_id": [ { "id": "RAB6B_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QR46", "type": "external" } ], "mass": 23462.0, "length": 208, "protein_name": "Ras-related protein Rab-6B", "gene_name": "RAB6B", "organism": "Bovine", "refseq_name": "ras-related protein Rab-6B", "refseq_ac": [ { "id": "NP_001094599", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094599", "type": "external" } ], "gene_names_uniprotkb": "RAB6B", "gene_names_refseq": "RAB6B", "protein_names_uniprotkb": "Ras-related protein Rab-6B; 3.6.5.2", "protein_names_refseq": "ras-related protein Rab-6B", "tax_id": 9913, "disease": "", "pathway": " (bta:526526); (R-BTA-6811436); (R-BTA-6811440); (R-BTA-8854214); (R-BTA-8873719); (R-BTA-8876198)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Recruits VPS13B to the Golgi membrane. Regulates the compacted morphology of the Golgi. Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells. Plays a role in neuron projection development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "2.4.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.41", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" }, { "id": "2.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0003925 G protein activity;GO:0031489 myosin V binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0031410 cytoplasmic vesicle;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0005794 Golgi apparatus;GO:0005829 cytosol", "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0007030 Golgi organization;GO:1903292 protein localization to Golgi membrane;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QR46-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9E5-1", "uniprot_id": [ { "id": "CTSRD_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9E5", "type": "external" } ], "mass": 88415.0, "length": 781, "protein_name": "Cation channel sperm-associated auxiliary subunit delta", "gene_name": "CATSPERD", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CATSPERD; TMEM146", "gene_names_refseq": "", "protein_names_uniprotkb": "Cation channel sperm-associated auxiliary subunit delta; CatSper-delta; CatSperdelta; Transmembrane protein 146", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1300642)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for CATSPER1 stability before intraflagellar transport and/or incorporation of the CatSper complex channel into the flagellar membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0036128 CatSper complex;GO:0097228 sperm principal piece", "go_biological_process": "GO:0007283 spermatogenesis;GO:0030317 flagellated sperm motility;GO:0048240 sperm capacitation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1B9E5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLA6-1", "uniprot_id": [ { "id": "CAF1A_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLA6", "type": "external" } ], "mass": 107258.0, "length": 964, "protein_name": "Chromatin assembly factor 1 subunit A", "gene_name": "CHAF1A", "organism": "Bovine", "refseq_name": "chromatin assembly factor 1 subunit A", "refseq_ac": [ { "id": "NP_001095312", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095312", "type": "external" } ], "gene_names_uniprotkb": "CHAF1A; CAF1P150; CAF", "gene_names_refseq": "CHAF1A", "protein_names_uniprotkb": "Chromatin assembly factor 1 subunit A; CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; Chromatin assembly factor I p150 subunit", "protein_names_refseq": "CAF-1 subunit A; CAF-I 150 kDa subunit; CAF-I p150; CAF-Ip150; chromatin assembly factor 1 subunit A; chromatin assembly factor 1, subunit A (p150); chromatin assembly factor I p150 subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:504535)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 11, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0070087 chromo shadow domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0033186 CAF-1 complex;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0006334 nucleosome assembly;GO:0006335 DNA replication-dependent chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLA6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D989-1", "uniprot_id": [ { "id": "EF1D_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D989", "type": "external" } ], "mass": 31142.0, "length": 280, "protein_name": "Elongation factor 1-delta", "gene_name": "EEF1D; TIGD5", "organism": "Bovine", "refseq_name": "elongation factor 1-delta isoform 2", "refseq_ac": [ { "id": "NP_001193549", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193549", "type": "external" } ], "gene_names_uniprotkb": "EEF1D; TIGD5; EEF1D", "gene_names_refseq": "EEF1D", "protein_names_uniprotkb": "Elongation factor 1-delta; EF-1-delta", "protein_names_refseq": "EF-1-delta; elongation factor 1-delta isoform 2; elongation factor 1-delta", "tax_id": 9913, "disease": "", "pathway": " (bta:516473); (R-BTA-156842)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "16305752;24239553;28667419", "class_list": "", "function": "EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP., [UniProtKB]; Findings present the first report on the alternative splicing of the bovine EEF1D gene., [RefSeq, PubMed]; Result suggests that the DNA methylation of EEF1D plays an important role in the spatial and temporal regulation of its expression and possibly have an effect on the milk production traits, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003746 translation elongation factor activity;GO:0003677 DNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005853 eukaryotic translation elongation factor 1 complex;GO:0005634 nucleus", "go_biological_process": "GO:0006414 translational elongation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A5D989-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4P4-1", "uniprot_id": [ { "id": "G45IP_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4P4", "type": "external" } ], "mass": 25746.0, "length": 222, "protein_name": "Large ribosomal subunit protein mL64", "gene_name": "GADD45GIP1", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein mL64", "refseq_ac": [ { "id": "NP_001073693", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073693", "type": "external" } ], "gene_names_uniprotkb": "GADD45GIP1; MRPL59", "gene_names_refseq": "GADD45GIP1; MRP-L59", "protein_names_uniprotkb": "Large ribosomal subunit protein mL64; 39S ribosomal protein L59, mitochondrial; Growth arrest and DNA damage-inducible proteins-interacting protein 1; MRP-L59", "protein_names_refseq": "39S ribosomal protein L59, mitochondrial; growth arrest and DNA damage-inducible proteins-interacting protein 1; growth arrest and DNA-damage-inducible, gamma interacting protein 1; large ribosomal subunit protein mL64", "tax_id": 9913, "disease": "", "pathway": " (bta:504718); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4P4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLN9-1", "uniprot_id": [ { "id": "VWA1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLN9", "type": "external" } ], "mass": 43738.0, "length": 413, "protein_name": "von Willebrand factor A domain-containing protein 1", "gene_name": "VWA1", "organism": "Bovine", "refseq_name": "von Willebrand factor A domain-containing protein 1 precursor", "refseq_ac": [ { "id": "NP_001096700", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096700", "type": "external" } ], "gene_names_uniprotkb": "VWA1", "gene_names_refseq": "VWA1", "protein_names_uniprotkb": "von Willebrand factor A domain-containing protein 1", "protein_names_refseq": "von Willebrand factor A domain-containing protein 1 precursor; von Willebrand factor A domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:505917); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Promotes matrix assembly (By similarity). Involved in the organization of skeletal muscles and in the formation of neuromuscular junctions (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Promotes matrix assembly. Involved in the organization of skeletal muscles and in the formation of neuromuscular junctions., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0042803 protein homodimerization activity;GO:0050436 microfibril binding", "go_cellular_component": "GO:0031012 extracellular matrix;GO:0005604 basement membrane;GO:0005840 ribosome;GO:0005576 extracellular region;GO:0005614 interstitial matrix", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLN9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7E3S5-1", "uniprot_id": [ { "id": "WDR4_BOVIN", "url": "https://www.uniprot.org/uniprot/A7E3S5", "type": "external" } ], "mass": 45858.0, "length": 414, "protein_name": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4", "gene_name": "WDR4", "organism": "Bovine", "refseq_name": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4", "refseq_ac": [ { "id": "NP_001093790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093790", "type": "external" } ], "gene_names_uniprotkb": "WDR4", "gene_names_refseq": "WDR4", "protein_names_uniprotkb": "tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; WD repeat-containing protein 4", "protein_names_refseq": "WD repeat domain 4 protein; WD repeat-containing protein 4; tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4; tRNA (guanine-N(7)-)-methyltransferase subunit WDR4", "tax_id": 9913, "disease": "", "pathway": " (bta:508051)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). In the METTL1-WDR4 methyltransferase complex, WDR4 acts as a scaffold for tRNA-binding. Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop. M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay. Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs. Also required for methylation of a specific subset of miRNAs, such as let-7. Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1., [UniProtKB, HAMAP]; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005694 chromosome;GO:0043527 tRNA methyltransferase complex;GO:0106143 tRNA (m7G46) methyltransferase complex", "go_biological_process": "GO:0006400 tRNA modification;GO:0006974 DNA damage response;GO:0106004 tRNA (guanine-N7)-methylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7E3S5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YY45-1", "uniprot_id": [ { "id": "IMPCT_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YY45", "type": "external" } ], "mass": 36333.0, "length": 318, "protein_name": "Protein IMPACT", "gene_name": "IMPACT", "organism": "Bovine", "refseq_name": "protein IMPACT", "refseq_ac": [ { "id": "NP_001095971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095971", "type": "external" } ], "gene_names_uniprotkb": "IMPACT", "gene_names_refseq": "IMPACT", "protein_names_uniprotkb": "Protein IMPACT; Imprinted and ancient gene protein homolog", "protein_names_refseq": "Impact homolog; imprinted and ancient gene protein homolog; protein IMPACT", "tax_id": 9913, "disease": "", "pathway": " (bta:517248)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q52UL6", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0045666 positive regulation of neuron differentiation;GO:0006446 regulation of translational initiation;GO:0034198 cellular response to amino acid starvation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YY45-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDR8-1", "uniprot_id": [ { "id": "COG7_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDR8", "type": "external" } ], "mass": 86527.0, "length": 770, "protein_name": "Conserved oligomeric Golgi complex subunit 7", "gene_name": "COG7", "organism": "Bovine", "refseq_name": "conserved oligomeric Golgi complex subunit 7", "refseq_ac": [ { "id": "NP_001076841", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076841", "type": "external" } ], "gene_names_uniprotkb": "COG7", "gene_names_refseq": "COG7", "protein_names_uniprotkb": "Conserved oligomeric Golgi complex subunit 7; COG complex subunit 7; Component of oligomeric Golgi complex 7", "protein_names_refseq": "COG complex subunit 7; conserved oligomeric Golgi complex subunit 7", "tax_id": 9913, "disease": "", "pathway": " (bta:504790); (R-BTA-6807878); (R-BTA-6811438); (R-BTA-6811440)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for normal Golgi function., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0017119 Golgi transport complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0009101 glycoprotein biosynthetic process;GO:0050821 protein stabilization;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0033365 protein localization to organelle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDR8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YVH9-1", "uniprot_id": [ { "id": "PYRD1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YVH9", "type": "external" } ], "mass": 55876.0, "length": 502, "protein_name": "tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1", "gene_name": "PYROXD1", "organism": "Bovine", "refseq_name": "tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1", "refseq_ac": [ { "id": "NP_001098804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098804", "type": "external" } ], "gene_names_uniprotkb": "PYROXD1", "gene_names_refseq": "PYROXD1", "protein_names_uniprotkb": "tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1; 1.6.99.1; Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1", "protein_names_refseq": "pyridine nucleotide-disulfide oxidoreductase domain 1; pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1; tRNA ligase complex-associated NAD(P)H dehydrogenase PYROXD1", "tax_id": 9913, "disease": "", "pathway": " (bta:505859)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Flavoprotein whose role is to protect RTCB, the catalytic subunit of the tRNA ligase complex (tRNA-LC) involved in tRNA splicing and unfolded protein response, from oxidative inactivation. It directly binds and shields the catalytic center of RTCB, prior to guanylylation, when it is inactive and its active site is vulnerable to oxidation under aerobic conditions. The interaction of PYROXD1 with RTCB is allosterically regulated by NAD(P)H binding and reduction of its FAD cofactor, while reoxidation of PYROXD1 thanks to its NADPH dehydrogenase activity triggers the timed release of RTCB, enabling its subsequent activation. Thereby, this protective mechanism may also function as a molecular timer, regulating RTCB activation through controlled release., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.99.1", "type": "external" }, { "id": "1.6.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.3.1", "type": "external" }, { "id": "1.14.13.225", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.225", "type": "external" } ], "go_molecular_function": "GO:0003954 NADH dehydrogenase activity;GO:0016174 NAD(P)H oxidase H2O2-forming activity;GO:0003959 NADPH dehydrogenase activity;GO:0140299 molecular sensor activity;GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030017 sarcomere", "go_biological_process": "GO:0008033 tRNA processing;GO:0034599 cellular response to oxidative stress;GO:0000968 tRNA exon ligation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YVH9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QP70-1", "uniprot_id": [ { "id": "SGCB_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QP70", "type": "external" } ], "mass": 34734.0, "length": 317, "protein_name": "Beta-sarcoglycan", "gene_name": "SGCB", "organism": "Bovine", "refseq_name": "beta-sarcoglycan", "refseq_ac": [ { "id": "NP_001095658", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095658", "type": "external" } ], "gene_names_uniprotkb": "SGCB", "gene_names_refseq": "SGCB", "protein_names_uniprotkb": "Beta-sarcoglycan; Beta-SG", "protein_names_refseq": "beta-SG; beta-sarcoglycan; sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)", "tax_id": 9913, "disease": "", "pathway": " (bta:535372); (R-BTA-9913351)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0042383 sarcolemma;GO:0016012 sarcoglycan complex", "go_biological_process": "GO:0007517 muscle organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QP70-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4K1-1", "uniprot_id": [ { "id": "C99L2_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4K1", "type": "external" } ], "mass": 22987.0, "length": 217, "protein_name": "CD99 antigen-like protein 2", "gene_name": "CD99L2", "organism": "Bovine", "refseq_name": "CD99 antigen-like protein 2 precursor", "refseq_ac": [ { "id": "NP_001077227", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077227", "type": "external" } ], "gene_names_uniprotkb": "CD99L2", "gene_names_refseq": "CD99L2", "protein_names_uniprotkb": "CD99 antigen-like protein 2", "protein_names_refseq": "CD99 antigen-like 2; CD99 antigen-like protein 2 precursor; CD99 antigen-like protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:613644)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in a late step of leukocyte extravasation helping cells to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1 (By similarity). Homophilic adhesion molecule, but these interactions may not be required for cell aggregation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4K1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4M2-1", "uniprot_id": [ { "id": "EMC10_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4M2", "type": "external" } ], "mass": 27425.0, "length": 262, "protein_name": "ER membrane protein complex subunit 10", "gene_name": "EMC10", "organism": "Bovine", "refseq_name": "ER membrane protein complex subunit 10 precursor", "refseq_ac": [ { "id": "NP_001073708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073708", "type": "external" } ], "gene_names_uniprotkb": "EMC10; INM02", "gene_names_refseq": "C18H19orf63; EMC10; INM02", "protein_names_uniprotkb": "ER membrane protein complex subunit 10", "protein_names_refseq": "ER membrane protein complex subunit 10 precursor; UPF0510 protein INM02; hematopoietic signal peptide-containing", "tax_id": 9913, "disease": "", "pathway": " (bta:507692)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0072546 EMC complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0001525 angiogenesis;GO:0010595 positive regulation of endothelial cell migration;GO:0045766 positive regulation of angiogenesis;GO:0001938 positive regulation of endothelial cell proliferation;GO:0071816 tail-anchored membrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4M2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7E2Z9-1", "uniprot_id": [ { "id": "ELAP2_BOVIN", "url": "https://www.uniprot.org/uniprot/A7E2Z9", "type": "external" } ], "mass": 105850.0, "length": 960, "protein_name": "Endosome/lysosome-associated apoptosis and autophagy regulator family member 2", "gene_name": "ELAPOR2", "organism": "Bovine", "refseq_name": "endosome/lysosome-associated apoptosis and autophagy regulator family member 2 precursor", "refseq_ac": [ { "id": "NP_001039703", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039703", "type": "external" } ], "gene_names_uniprotkb": "ELAPOR2", "gene_names_refseq": "EIG121L; ELAPOR2; KIAA1324L", "protein_names_uniprotkb": "Endosome/lysosome-associated apoptosis and autophagy regulator family member 2", "protein_names_refseq": "KIAA1324 like; KIAA1324-like ortholog; UPF0577 protein KIAA1324-like homolog; endosome/lysosome-associated apoptosis and autophagy regulator family member 2 precursor; estrogen-induced gene 121-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:518313)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a regulator of the BMP signaling pathway and may be involved in epidermal differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070700 BMP receptor binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "GO:0030513 positive regulation of BMP signaling pathway;GO:0045684 positive regulation of epidermis development;GO:0051961 negative regulation of nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7E2Z9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7E305-1", "uniprot_id": [ { "id": "ZSWM8_BOVIN", "url": "https://www.uniprot.org/uniprot/A7E305", "type": "external" } ], "mass": 152380.0, "length": 1413, "protein_name": "Zinc finger SWIM domain-containing protein 8", "gene_name": "ZSWIM8", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ZSWIM8", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger SWIM domain-containing protein 8", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs) (By similarity). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation (By similarity). Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target (By similarity). May also acts as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation (By similarity). Plays an essential role for proper embryonic development of heart and lung. Controls protein quality of DAB1, a key signal molecule for brain development, thus protecting its signaling strength. Mechanistically, recognizes intrinsically disordered regions of DAB1 and eliminates misfolded DAB1 that cannot be properly phosphorylated (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0031462 Cul2-RING ubiquitin ligase complex;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:2000627 positive regulation of miRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7E305-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QP55-1", "uniprot_id": [ { "id": "SFXN3_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QP55", "type": "external" } ], "mass": 35708.0, "length": 321, "protein_name": "Sideroflexin-3", "gene_name": "SFXN3", "organism": "Bovine", "refseq_name": "sideroflexin-3", "refseq_ac": [ { "id": "NP_001095416", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095416", "type": "external" } ], "gene_names_uniprotkb": "SFXN3", "gene_names_refseq": "SFXN3", "protein_names_uniprotkb": "Sideroflexin-3", "protein_names_refseq": "sideroflexin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:511755)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial serine transporter that mediates transport of serine into mitochondria, an important step of the one-carbon metabolism pathway. Mitochondrial serine is converted to glycine and formate, which then exits to the cytosol where it is used to generate the charged folates that serve as one-carbon donors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0015194 L-serine transmembrane transporter activity;GO:0015075 monoatomic ion transmembrane transporter activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006730 one-carbon metabolic process;GO:1990542 mitochondrial transmembrane transport;GO:0140300 serine import into mitochondrion;GO:0006865 amino acid transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QP55-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUD1-1", "uniprot_id": [ { "id": "GPN1_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUD1", "type": "external" } ], "mass": 41450.0, "length": 373, "protein_name": "GPN-loop GTPase 1", "gene_name": "GPN1", "organism": "Bovine", "refseq_name": "GPN-loop GTPase 1", "refseq_ac": [ { "id": "NP_001076861", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076861", "type": "external" } ], "gene_names_uniprotkb": "GPN1; XAB1", "gene_names_refseq": "GPN1; XAB1", "protein_names_uniprotkb": "GPN-loop GTPase 1; 3.6.5.-; XPA-binding protein 1", "protein_names_refseq": "GPN-loop GTPase 1; XPA binding protein 1, GTPase; XPA-binding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:508522)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTPase involved in the correct assembly of RNA polymerase II (RNAPII) complex, ensuring proper nuclear import of RNAPII. In vitro, exhibits a chaperone-like activity and a chaperone substrate protein can stimulate its GTPase activity. It is proposed to bind exposed hydrophobic peptide regions of newly synthesized RNAP II subunit, triggering the opening of a hydrophobic pocket in its GDP-bound state. This interaction likely traps exposed hydrophobic regions, preventing misassembly and providing a time window for association with the cognate RNAP II subunit. Peptide binding promotes GDP release, and increasing GTP affinity to facilitate GTP rebinding. Subsequent GTP hydrolysis would then lead to the release of the bound RNAP II subunit to enable association with cognate subunits and RNAP II assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUD1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KMV2-1", "uniprot_id": [ { "id": "RD23A_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KMV2", "type": "external" } ], "mass": 39589.0, "length": 362, "protein_name": "Lysine-specific demethylase RAD23A", "gene_name": "RAD23A", "organism": "Bovine", "refseq_name": "lysine-specific demethylase RAD23A", "refseq_ac": [ { "id": "NP_001076083", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076083", "type": "external" } ], "gene_names_uniprotkb": "RAD23A", "gene_names_refseq": "RAD23A", "protein_names_uniprotkb": "Lysine-specific demethylase RAD23A; 1.14.11.-; UV excision repair protein RAD23 homolog A", "protein_names_refseq": "UV excision repair protein RAD23 homolog A; lysine-specific demethylase RAD23A", "tax_id": 9913, "disease": "", "pathway": " (bta:540564); (R-BTA-5689877); (R-BTA-5696394); (R-BTA-5696395)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation, transcriptional regulation, and viral replication. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3. Involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. Involved in nucleotide excision repair, is considered functionally equivalent to RAD23B in global genome nucleotide excision repair (GG-NER) through its association with XPC. In vitro, the XPC-RAD23A complex demonstrates NER activity (By similarity). Can stabilize XPC (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "2.4.2.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" } ], "go_molecular_function": "GO:0035575 histone H4K20 demethylase activity;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0003684 damaged DNA binding;GO:0043130 ubiquitin binding;GO:0070628 proteasome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000502 proteasome complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006289 nucleotide-excision repair;GO:0045787 positive regulation of cell cycle;GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process;GO:0031648 protein destabilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KMV2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUY7-1", "uniprot_id": [ { "id": "MOC2B_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUY7", "type": "external" } ], "mass": 21173.0, "length": 189, "protein_name": "Molybdopterin synthase catalytic subunit", "gene_name": "MOCS2", "organism": "Bovine", "refseq_name": "molybdopterin synthase catalytic subunit", "refseq_ac": [ { "id": "NP_001014867", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014867", "type": "external" } ], "gene_names_uniprotkb": "MOCS2", "gene_names_refseq": "MOCS2", "protein_names_uniprotkb": "Molybdopterin synthase catalytic subunit; 2.8.1.12; MOCS2B; Molybdenum cofactor synthesis protein 2 large subunit; Molybdenum cofactor synthesis protein 2B", "protein_names_refseq": "molybdopterin synthase catalytic subunit; molybdopterin synthase small subunit MOCS2A", "tax_id": 9913, "disease": "", "pathway": " (bta:507986)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin., [UniProtKB, HAMAP, UniProtKB]; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group (By similarity). Together with MBIP, inhibits the activity of stress kinase EIF2AK2/PKR; this may suppress JNK activation and subsequent stress-responsive transcription, or suppress eIF2a phosphorylation to favor translation (By similarity)., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q58DT2", "ec_number_list": [ { "id": "2.8.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.12", "type": "external" } ], "go_molecular_function": "GO:0030366 molybdopterin synthase activity;GO:0000166 nucleotide binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990140 molybdopterin synthase complex", "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4FUY7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJZ2-1", "uniprot_id": [ { "id": "PPM1L_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJZ2", "type": "external" } ], "mass": 41042.0, "length": 360, "protein_name": "Protein phosphatase 1L", "gene_name": "PPM1L", "organism": "Bovine", "refseq_name": "protein phosphatase 1L", "refseq_ac": [ { "id": "NP_001092588", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092588", "type": "external" } ], "gene_names_uniprotkb": "PPM1L; PP2CE", "gene_names_refseq": "PP2CE; PPM1L", "protein_names_uniprotkb": "Protein phosphatase 1L; 3.1.3.16; PP2C-epsilon; Protein phosphatase 1-like; Protein phosphatase 2C isoform epsilon", "protein_names_refseq": "PP2C-epsilon; protein phosphatase 1L; protein phosphatase 2C epsilon", "tax_id": 9913, "disease": "", "pathway": " (bta:541235); (R-BTA-1660661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004722 protein serine/threonine phosphatase activity", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJZ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPT6-1", "uniprot_id": [ { "id": "ZN274_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPT6", "type": "external" } ], "mass": 69254.0, "length": 620, "protein_name": "Neurotrophin receptor-interacting factor homolog", "gene_name": "ZNF274", "organism": "Bovine", "refseq_name": "neurotrophin receptor-interacting factor homolog", "refseq_ac": [ { "id": "NP_001094623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094623", "type": "external" } ], "gene_names_uniprotkb": "ZNF274", "gene_names_refseq": "ZNF274", "protein_names_uniprotkb": "Neurotrophin receptor-interacting factor homolog; Zinc finger protein 274", "protein_names_refseq": "neurotrophin receptor-interacting factor homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:534170); (R-BTA-212436)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8D6", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QPT6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KMV1-1", "uniprot_id": [ { "id": "SHKB1_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KMV1", "type": "external" } ], "mass": 75885.0, "length": 704, "protein_name": "SH3KBP1-binding protein 1", "gene_name": "SHKBP1", "organism": "Bovine", "refseq_name": "SH3KBP1-binding protein 1", "refseq_ac": [ { "id": "NP_001076076", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076076", "type": "external" } ], "gene_names_uniprotkb": "SHKBP1", "gene_names_refseq": "SHKBP1", "protein_names_uniprotkb": "SH3KBP1-binding protein 1", "protein_names_refseq": "SH3KBP1-binding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:512402)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005764 lysosome", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KMV1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLH5-1", "uniprot_id": [ { "id": "ERI3_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLH5", "type": "external" } ], "mass": 37330.0, "length": 337, "protein_name": "ERI1 exoribonuclease 3", "gene_name": "ERI3", "organism": "Bovine", "refseq_name": "ERI1 exoribonuclease 3 isoform 1", "refseq_ac": [ { "id": "NP_001106713", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106713", "type": "external" } ], "gene_names_uniprotkb": "ERI3; PINT1; PRNPIP1; PRNPIP", "gene_names_refseq": "ERI3; PRNPIP", "protein_names_uniprotkb": "ERI1 exoribonuclease 3; 3.1.-.-; Prion interactor 1; Prion protein-interacting protein", "protein_names_refseq": "ERI1 exoribonuclease 3 isoform 1; ERI1 exoribonuclease 3; prion interactor 1; prion protein interacting protein", "tax_id": 9913, "disease": "", "pathway": " (bta:540516)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0060906 negative regulation of regulatory ncRNA-mediated heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLH5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7E346-1", "uniprot_id": [ { "id": "MASTR_BOVIN", "url": "https://www.uniprot.org/uniprot/A7E346", "type": "external" } ], "mass": 46215.0, "length": 430, "protein_name": "MEF2-activating motif and SAP domain-containing transcriptional regulator", "gene_name": "MAMSTR", "organism": "Bovine", "refseq_name": "MEF2-activating motif and SAP domain-containing transcriptional regulator", "refseq_ac": [ { "id": "NP_001181940", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001181940", "type": "external" } ], "gene_names_uniprotkb": "MAMSTR; MASTR", "gene_names_refseq": "MAMSTR", "protein_names_uniprotkb": "MEF2-activating motif and SAP domain-containing transcriptional regulator; MEF2-activating SAP transcriptional regulatory protein", "protein_names_refseq": "MEF2-activating SAP transcriptional regulatory protein; MEF2-activating motif and SAP domain-containing transcriptional regulator", "tax_id": 9913, "disease": "", "pathway": " (bta:505540)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7E346-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H7A8-1", "uniprot_id": [ { "id": "TDIF1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H7A8", "type": "external" } ], "mass": 37012.0, "length": 329, "protein_name": "Deoxynucleotidyltransferase terminal-interacting protein 1", "gene_name": "DNTTIP1", "organism": "Bovine", "refseq_name": "deoxynucleotidyltransferase terminal-interacting protein 1", "refseq_ac": [ { "id": "NP_001092346", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092346", "type": "external" } ], "gene_names_uniprotkb": "DNTTIP1; TDIF1", "gene_names_refseq": "DNTTIP1", "protein_names_uniprotkb": "Deoxynucleotidyltransferase terminal-interacting protein 1; TdIF1; TdT-interacting factor 1; Terminal deoxynucleotidyltransferase-interacting factor 1", "protein_names_refseq": "deoxynucleotidyltransferase terminal-interacting protein 1; tdIF1; tdT-interacting factor 1; terminal deoxynucleotidyltransferase-interacting factor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:505524); (R-BTA-9764725)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Increases DNTT terminal deoxynucleotidyltransferase activity (in vitro). Also acts as a transcriptional regulator, binding to the consensus sequence 5'-GNTGCATG-3' following an AT-tract. Associates with RAB20 promoter and positively regulates its transcription. Binds DNA and nucleosomes; may recruit HDAC1 complexes to nucleosomes or naked DNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0031491 nucleosome binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000118 histone deacetylase complex;GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H7A8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4R8-1", "uniprot_id": [ { "id": "CDC23_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4R8", "type": "external" } ], "mass": 68780.0, "length": 597, "protein_name": "Cell division cycle protein 23 homolog", "gene_name": "CDC23", "organism": "Bovine", "refseq_name": "cell division cycle protein 23 homolog", "refseq_ac": [ { "id": "NP_001073735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073735", "type": "external" } ], "gene_names_uniprotkb": "CDC23; ANAPC8", "gene_names_refseq": "APC8; CDC23", "protein_names_uniprotkb": "Cell division cycle protein 23 homolog; APC8; Anaphase-promoting complex subunit 8; Cyclosome subunit 8", "protein_names_refseq": "anaphase-promoting complex subunit 8; cell division cycle 23 homolog; cell division cycle protein 23 homolog; cyclosome subunit 8", "tax_id": 9913, "disease": "", "pathway": " (bta:512651); (R-BTA-141430); (R-BTA-174048); (R-BTA-174084); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-176407); (R-BTA-176408); (R-BTA-176409); (R-BTA-176412); (R-BTA-179409); (R-BTA-2467813); (R-BTA-2559582); (R-BTA-68867); (R-BTA-69017); (R-BTA-983168)", "pathway_count": 17, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0045842 positive regulation of mitotic metaphase/anaphase transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4R8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9W9-1", "uniprot_id": [ { "id": "UBP42_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9W9", "type": "external" } ], "mass": 146748.0, "length": 1333, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 42", "gene_name": "USP42", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "USP42", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 42; 3.4.19.12; Deubiquitinating enzyme 42; Ubiquitin thioesterase 42; Ubiquitin-specific-processing protease 42", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:532721); (R-BTA-5689880)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deubiquitinating enzyme which may play an important role during spermatogenesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0007283 spermatogenesis;GO:0016579 protein deubiquitination;GO:0030154 cell differentiation;GO:0031647 regulation of protein stability", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9W9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7K8-1", "uniprot_id": [ { "id": "PD2R_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7K8", "type": "external" } ], "mass": 40372.0, "length": 361, "protein_name": "Prostaglandin D2 receptor", "gene_name": "PTGDR", "organism": "Bovine", "refseq_name": "prostaglandin D2 receptor", "refseq_ac": [ { "id": "NP_001091503", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091503", "type": "external" } ], "gene_names_uniprotkb": "PTGDR", "gene_names_refseq": "PTGDR", "protein_names_uniprotkb": "Prostaglandin D2 receptor; PGD receptor; PGD2 receptor; Prostanoid DP receptor", "protein_names_refseq": "PGD receptor; PGD2 receptor; Prostanoid DP receptor; prostaglandin D2 receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:515331); (R-BTA-391908); (R-BTA-418555)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004956 prostaglandin D receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006954 inflammatory response;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0043303 mast cell degranulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7K8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFD0-1", "uniprot_id": [ { "id": "KAD5_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFD0", "type": "external" } ], "mass": 63273.0, "length": 562, "protein_name": "Adenylate kinase isoenzyme 5", "gene_name": "AK5; Ak5", "organism": "Bovine", "refseq_name": "adenylate kinase isoenzyme 5", "refseq_ac": [ { "id": "NP_001077226", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077226", "type": "external" } ], "gene_names_uniprotkb": "AK5; Ak5", "gene_names_refseq": "AK 5; AK5", "protein_names_uniprotkb": "Adenylate kinase isoenzyme 5; 2.7.4.3; 2.7.4.6; AK 5; ATP-AMP transphosphorylase 5", "protein_names_refseq": "ATP-AMP transphosphorylase 5; adenylate kinase isoenzyme 5", "tax_id": 9913, "disease": "", "pathway": " (bta:613448); (R-BTA-499943)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.10", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "2.7.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.4", "type": "external" }, { "id": "2.7.4.14", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.14", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" } ], "go_molecular_function": "GO:0004017 AMP kinase activity;GO:0005524 ATP binding;GO:0004550 nucleoside diphosphate kinase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046034 ATP metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFD0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE33-1", "uniprot_id": [ { "id": "LYPD8_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE33", "type": "external" } ], "mass": 24724.0, "length": 230, "protein_name": "Ly6/PLAUR domain-containing protein 8", "gene_name": "LYPD8", "organism": "Bovine", "refseq_name": "ly6/PLAUR domain-containing protein 8 precursor", "refseq_ac": [ { "id": "NP_001075931", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075931", "type": "external" } ], "gene_names_uniprotkb": "LYPD8", "gene_names_refseq": "LYPD8", "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 8", "protein_names_refseq": "ly6/PLAUR domain-containing protein 8 precursor; ly6/PLAUR domain-containing protein 8; phospholipase inhibitor", "tax_id": 9913, "disease": "", "pathway": " (bta:617425); (R-BTA-163125)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis., [UniProtKB, UniProtKB]", "predicted_glycosites": 13, "predicted_n_glycosites": 13, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 13, "binding_glycan_count": 0, "secondary_ac_list": "F1N1X9", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0050829 defense response to Gram-negative bacterium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2VE33-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H7I8-1", "uniprot_id": [ { "id": "TBC14_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H7I8", "type": "external" } ], "mass": 78025.0, "length": 692, "protein_name": "TBC1 domain family member 14", "gene_name": "TBC1D14", "organism": "Bovine", "refseq_name": "TBC1 domain family member 14", "refseq_ac": [ { "id": "NP_001092646", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092646", "type": "external" } ], "gene_names_uniprotkb": "TBC1D14", "gene_names_refseq": "TBC1D14", "protein_names_uniprotkb": "TBC1 domain family member 14", "protein_names_refseq": "TBC1 domain family member 14", "tax_id": 9913, "disease": "", "pathway": " (bta:618286); (R-BTA-8854214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the regulation of starvation-induced autophagosome formation. Together with the TRAPPIII complex, regulates a constitutive trafficking step from peripheral recycling endosomes to the early Golgi, maintaining the cycling pool of ATG9 required for initiation of autophagy., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0019899 enzyme binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0055037 recycling endosome;GO:0005776 autophagosome;GO:0031410 cytoplasmic vesicle;GO:0005773 vacuole", "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:2000785 regulation of autophagosome assembly;GO:0010507 negative regulation of autophagy;GO:0071955 recycling endosome to Golgi transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H7I8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YY49-1", "uniprot_id": [ { "id": "SURF4_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YY49", "type": "external" } ], "mass": 30422.0, "length": 269, "protein_name": "Surfeit locus protein 4", "gene_name": "SURF4", "organism": "Bovine", "refseq_name": "surfeit locus protein 4", "refseq_ac": [ { "id": "NP_001095979", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095979", "type": "external" } ], "gene_names_uniprotkb": "SURF4", "gene_names_refseq": "SURF4", "protein_names_uniprotkb": "Surfeit locus protein 4", "protein_names_refseq": "surfeit locus protein 4", "tax_id": 9913, "disease": "", "pathway": " (bta:526045); (R-BTA-6798695); (R-BTA-6811434)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion. Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis. Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins. Promotes the secretion of PCSK9. Also mediates the efficient secretion of erythropoietin (EPO). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038024 cargo receptor activity;GO:0097020 COPII receptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0032368 regulation of lipid transport;GO:0042953 lipoprotein transport;GO:0055088 lipid homeostasis;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YY49-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLC6-1", "uniprot_id": [ { "id": "YIPF6_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLC6", "type": "external" } ], "mass": 26184.0, "length": 236, "protein_name": "Protein YIPF6", "gene_name": "YIPF6", "organism": "Bovine", "refseq_name": "protein YIPF6", "refseq_ac": [ { "id": "NP_001094676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094676", "type": "external" } ], "gene_names_uniprotkb": "YIPF6", "gene_names_refseq": "YIPF6", "protein_names_uniprotkb": "Protein YIPF6; YIP1 family member 6", "protein_names_refseq": "YIP1 family member 6; protein YIPF6", "tax_id": 9913, "disease": "", "pathway": " (bta:540347); (R-BTA-432722)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be required for stable YIPF1 and YIPF2 protein expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005797 Golgi medial cisterna;GO:0005802 trans-Golgi network;GO:0000138 Golgi trans cisterna;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLC6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D9C6-1", "uniprot_id": [ { "id": "MAF1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D9C6", "type": "external" } ], "mass": 29054.0, "length": 260, "protein_name": "Repressor of RNA polymerase III transcription MAF1 homolog", "gene_name": "MAF1", "organism": "Bovine", "refseq_name": "repressor of RNA polymerase III transcription MAF1 homolog isoform X1", "refseq_ac": [ { "id": "XP_005215224", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005215224", "type": "external" } ], "gene_names_uniprotkb": "MAF1", "gene_names_refseq": "MAF1", "protein_names_uniprotkb": "Repressor of RNA polymerase III transcription MAF1 homolog", "protein_names_refseq": "repressor of RNA polymerase III transcription MAF1 homolog isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8943724)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (By similarity). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB. When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout. Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000994 RNA polymerase III core binding;GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding;GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding;GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016480 negative regulation of transcription by RNA polymerase III;GO:0016479 negative regulation of transcription by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5D9C6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQW0-1", "uniprot_id": [ { "id": "ZN143_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQW0", "type": "external" } ], "mass": 66079.0, "length": 613, "protein_name": "Zinc finger protein 143", "gene_name": "ZNF143", "organism": "Bovine", "refseq_name": "zinc finger protein 143", "refseq_ac": [ { "id": "NP_001095624", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095624", "type": "external" } ], "gene_names_uniprotkb": "ZNF143; STAF", "gene_names_refseq": "ZNF143", "protein_names_uniprotkb": "Zinc finger protein 143; Selenocysteine tRNA gene transcription-activating factor", "protein_names_refseq": "selenocysteine tRNA gene transcription-activating factor; zinc finger protein 143", "tax_id": 9913, "disease": "", "pathway": " (bta:533243); (R-BTA-6807505); (R-BTA-76071)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that activates expression of genes transcribed by both RNA polymerases II and III, and which is required to safeguard mitochondrial activity. Specifically recognizes and binds the Staf-binding site (SBS), a consensus DNA-binding motif present in thousands of promoters. Activates the gene for selenocysteine tRNA (tRNAsec). Activates expression of small nuclear RNA (snRNA) transcribed by RNA polymerases II and III (By similarity). Also activates expression of mRNAs and acts as a key regulator of cell proliferation and differentiation by specifically activating expression of a subset of nuclear-encoded mitochondrial genes, thereby controlling mitochondrial function. Involved in the maintenance of embryonic stem cells by promoting association of POU5F1/OCT4 to promoters, leading to NANOG expresion (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0001046 core promoter sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQW0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB43-1", "uniprot_id": [ { "id": "MTMR9_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB43", "type": "external" } ], "mass": 63486.0, "length": 549, "protein_name": "Myotubularin-related protein 9", "gene_name": "MTMR9", "organism": "Bovine", "refseq_name": "myotubularin-related protein 9", "refseq_ac": [ { "id": "NP_001094657", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094657", "type": "external" } ], "gene_names_uniprotkb": "MTMR9", "gene_names_refseq": "MTMR9", "protein_names_uniprotkb": "Myotubularin-related protein 9; Inactive phosphatidylinositol 3-phosphatase 9", "protein_names_refseq": "myotubularin-related protein 9", "tax_id": 9913, "disease": "", "pathway": " (bta:539174); (R-BTA-1660499)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols (By similarity). Positively regulates lipid phosphatase MTMR7 catalytic activity (By similarity). Increases MTMR8 catalytic activity towards phosphatidylinositol 3-phosphate. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Stabilizes MTMR8 protein levels. Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles. Negatively regulates autophagy, in part via its association with MTMR8. Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6. Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0032587 ruffle membrane", "go_biological_process": "GO:0010507 negative regulation of autophagy;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7MB43-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUA8-1", "uniprot_id": [ { "id": "CAZA1_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUA8", "type": "external" } ], "mass": 32932.0, "length": 286, "protein_name": "F-actin-capping protein subunit alpha-1", "gene_name": "CAPZA1", "organism": "Bovine", "refseq_name": "F-actin-capping protein subunit alpha-1", "refseq_ac": [ { "id": "NP_001076949", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076949", "type": "external" } ], "gene_names_uniprotkb": "CAPZA1", "gene_names_refseq": "CAPZA1", "protein_names_uniprotkb": "F-actin-capping protein subunit alpha-1; CapZ alpha-1", "protein_names_refseq": "CapZ alpha-1; F-actin capping protein alpha-1 subunit; F-actin-capping protein subunit alpha-1; capping actin protein of muscle Z-line alpha subunit 1; capping protein (actin filament) muscle Z-line, alpha 1", "tax_id": 9913, "disease": "", "pathway": " (bta:534656); (R-BTA-879415)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0003779 actin binding", "go_cellular_component": "GO:0005829 cytosol;GO:0008290 F-actin capping protein complex;GO:0030863 cortical cytoskeleton;GO:0071203 WASH complex", "go_biological_process": "GO:0034329 cell junction assembly;GO:0030036 actin cytoskeleton organization;GO:0051016 barbed-end actin filament capping", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4FUA8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7F5-1", "uniprot_id": [ { "id": "DJC27_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7F5", "type": "external" } ], "mass": 30759.0, "length": 273, "protein_name": "DnaJ homolog subfamily C member 27", "gene_name": "DNAJC27", "organism": "Bovine", "refseq_name": "dnaJ homolog subfamily C member 27", "refseq_ac": [ { "id": "NP_001091578", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091578", "type": "external" } ], "gene_names_uniprotkb": "DNAJC27; RBJ", "gene_names_refseq": "DNAJC27; RBJ", "protein_names_uniprotkb": "DnaJ homolog subfamily C member 27; Rab and DnaJ domain-containing protein", "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 27; dnaJ homolog subfamily C member 27; rab and DnaJ domain containing; rab and DnaJ domain-containing protein", "tax_id": 9913, "disease": "", "pathway": " (bta:540033)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding", "go_cellular_component": "GO:0005634 nucleus;GO:0030670 phagocytic vesicle membrane", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7F5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BA80-1", "uniprot_id": [ { "id": "E1BA80_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BA80", "type": "external" } ], "mass": 280186.0, "length": 2543, "protein_name": "Myosin XVIIIB", "gene_name": "MYO18B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MYO18B", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin XVIIIB", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0003774 cytoskeletal motor activity;GO:0051015 actin filament binding", "go_cellular_component": "GO:0016459 myosin complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0032982 myosin filament", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BA80-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BAD4-1", "uniprot_id": [ { "id": "E1BAD4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BAD4", "type": "external" } ], "mass": 51836.0, "length": 480, "protein_name": "Runt-related transcription factor", "gene_name": "RUNX1", "organism": "Bovine", "refseq_name": "runt-related transcription factor 1", "refseq_ac": [ { "id": "NP_001243507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243507", "type": "external" } ], "gene_names_uniprotkb": "RUNX1", "gene_names_refseq": "RUNX1", "protein_names_uniprotkb": "Runt-related transcription factor", "protein_names_refseq": "acute myeloid leukemia 1; aml1 oncogene); aml1 oncogene; factor, runt domain, alpha subunit 2; runt related transcription factor 1; runt-related transcription factor 1 (acute myeloid leukemia 1; runt-related transcription factor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:529631)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0005524 ATP binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0016513 core-binding factor complex;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0051240 positive regulation of multicellular organismal process;GO:0051094 positive regulation of developmental process;GO:2000026 regulation of multicellular organismal development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BAD4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9X7-1", "uniprot_id": [ { "id": "E1B9X7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9X7", "type": "external" } ], "mass": 81536.0, "length": 710, "protein_name": "Glycogen [starch] synthase", "gene_name": "GYS2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GYS2", "gene_names_refseq": "", "protein_names_uniprotkb": "Glycogen [starch] synthase; 2.4.1.11", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3322077)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan., [UniProtKB, UniProtKB, UniProtKB]; Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.186", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.186", "type": "external" }, { "id": "2.4.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.18", "type": "external" }, { "id": "2.4.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.11", "type": "external" } ], "go_molecular_function": "GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0005978 glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9X7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YSY2-1", "uniprot_id": [ { "id": "AFG2B_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YSY2", "type": "external" } ], "mass": 82554.0, "length": 767, "protein_name": "ATPase family gene 2 protein homolog B", "gene_name": "AFG2B", "organism": "Bovine", "refseq_name": "ATPase family gene 2 protein homolog B", "refseq_ac": [ { "id": "NP_001099095", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099095", "type": "external" } ], "gene_names_uniprotkb": "AFG2B; SPATA5L1", "gene_names_refseq": "AFG2B; SPATA5L1", "protein_names_uniprotkb": "ATPase family gene 2 protein homolog B; 3.6.4.10; AFG2 AAA ATPase homolog B; Ribosome biogenesis protein SPATA5L1; Spermatogenesis-associated protein 5-like protein 1", "protein_names_refseq": "AFG2 AAA ATPase homolog B; ATPase family gene 2 protein homolog B; ribosome biogenesis protein SPATA5L1; spermatogenesis-associated protein 5-like protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:533070)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:1990275 preribosome binding;GO:0005524 ATP binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0042273 ribosomal large subunit biogenesis;GO:0006260 DNA replication;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0051228 mitotic spindle disassembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YSY2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUX8-1", "uniprot_id": [ { "id": "ACL6B_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUX8", "type": "external" } ], "mass": 46891.0, "length": 426, "protein_name": "Actin-like protein 6B", "gene_name": "ACTL6B", "organism": "Bovine", "refseq_name": "actin-like protein 6B", "refseq_ac": [ { "id": "NP_001076839", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076839", "type": "external" } ], "gene_names_uniprotkb": "ACTL6B; ACTL6; BAF53B", "gene_names_refseq": "ACTL6B; BAF53B", "protein_names_uniprotkb": "Actin-like protein 6B; Actin-related protein Baf53b; ArpNalpha; BAF53B; BRG1-associated factor 53B", "protein_names_refseq": "BRG1-associated factor 53B; actin-like protein 6B; actin-related protein Baf53b; arpNalpha", "tax_id": 9913, "disease": "", "pathway": " (bta:504476); (R-BTA-3214858); (R-BTA-8939243)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth. Essential for neuronal maturation and dendrite development (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0016514 SWI/SNF complex;GO:0035267 NuA4 histone acetyltransferase complex;GO:0071565 nBAF complex;GO:0005634 nucleus", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0016358 dendrite development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUX8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLE1-1", "uniprot_id": [ { "id": "TDRD7_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLE1", "type": "external" } ], "mass": 123899.0, "length": 1098, "protein_name": "Tudor domain-containing protein 7", "gene_name": "TDRD7", "organism": "Bovine", "refseq_name": "tudor domain-containing protein 7", "refseq_ac": [ { "id": "NP_001093779", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093779", "type": "external" } ], "gene_names_uniprotkb": "TDRD7", "gene_names_refseq": "TDRD7", "protein_names_uniprotkb": "Tudor domain-containing protein 7", "protein_names_refseq": "tudor domain-containing protein 7", "tax_id": 9913, "disease": "", "pathway": " (bta:506702)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0035770 ribonucleoprotein granule;GO:0043186 P granule;GO:0005737 cytoplasm", "go_biological_process": "GO:0030719 P granule organization;GO:0007283 spermatogenesis;GO:0010608 post-transcriptional regulation of gene expression;GO:0034587 piRNA processing;GO:0002089 lens morphogenesis in camera-type eye", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLE1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B945-1", "uniprot_id": [ { "id": "E1B945_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B945", "type": "external" } ], "mass": 92076.0, "length": 809, "protein_name": "Anaphase-promoting complex subunit 4", "gene_name": "ANAPC4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ANAPC4", "gene_names_refseq": "", "protein_names_uniprotkb": "Anaphase-promoting complex subunit 4; Cyclosome subunit 4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-141430); (R-BTA-174048); (R-BTA-174084); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-176407); (R-BTA-176408); (R-BTA-176409); (R-BTA-176412); (R-BTA-179409); (R-BTA-2467813); (R-BTA-2559582); (R-BTA-68867); (R-BTA-69017); (R-BTA-983168)", "pathway_count": 16, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0005680 anaphase-promoting complex;GO:0034399 nuclear periphery", "go_biological_process": "GO:0051301 cell division;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0030071 regulation of mitotic metaphase/anaphase transition;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B945-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUC9-1", "uniprot_id": [ { "id": "RHPN2_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUC9", "type": "external" } ], "mass": 77105.0, "length": 686, "protein_name": "Rhophilin-2", "gene_name": "RHPN2", "organism": "Bovine", "refseq_name": "rhophilin-2", "refseq_ac": [ { "id": "NP_001076939", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076939", "type": "external" } ], "gene_names_uniprotkb": "RHPN2", "gene_names_refseq": "RHPN2", "protein_names_uniprotkb": "Rhophilin-2; GTP-Rho-binding protein 2", "protein_names_refseq": "GTP-Rho-binding protein 2; rhophilin-2", "tax_id": 9913, "disease": "", "pathway": " (bta:533687); (R-BTA-5666185); (R-BTA-8980692)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0051497 negative regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUC9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNM8-1", "uniprot_id": [ { "id": "SYTC2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNM8", "type": "external" } ], "mass": 83076.0, "length": 724, "protein_name": "Threonine--tRNA ligase 2, cytoplasmic", "gene_name": "TARS3", "organism": "Bovine", "refseq_name": "threonine--tRNA ligase 2, cytoplasmic", "refseq_ac": [ { "id": "NP_001095559", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095559", "type": "external" } ], "gene_names_uniprotkb": "TARS3; TARSL2", "gene_names_refseq": "TARS3; TARSL2", "protein_names_uniprotkb": "Threonine--tRNA ligase 2, cytoplasmic; 6.1.1.3; ThrRS; Threonyl-tRNA synthetase protein 3; Threonyl-tRNA synthetase", "protein_names_refseq": "Probable threonyl-tRNA synthetase 2, cytoplasmic; probable threonine--tRNA ligase 2, cytoplasmic; thrRS; threonine--tRNA ligase 2, cytoplasmic; threonyl-tRNA synthetase like 2; threonyl-tRNA synthetase protein 3; threonyl-tRNA synthetase-like protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:525350)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.3", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004829 threonine-tRNA ligase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006435 threonyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QNM8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE14-1", "uniprot_id": [ { "id": "SAE1_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE14", "type": "external" } ], "mass": 38306.0, "length": 346, "protein_name": "SUMO-activating enzyme subunit 1", "gene_name": "SAE1", "organism": "Bovine", "refseq_name": "SUMO-activating enzyme subunit 1", "refseq_ac": [ { "id": "NP_001075180", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075180", "type": "external" } ], "gene_names_uniprotkb": "SAE1", "gene_names_refseq": "SAE1", "protein_names_uniprotkb": "SUMO-activating enzyme subunit 1; Ubiquitin-like 1-activating enzyme E1A", "protein_names_refseq": "SUMO-activating enzyme subunit 1; ubiquitin-like 1-activating enzyme E1A", "tax_id": 9913, "disease": "", "pathway": " (bta:505512); (R-BTA-3065676); (R-BTA-3065678)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019948 SUMO activating enzyme activity;GO:0046982 protein heterodimerization activity;GO:0043008 ATP-dependent protein binding;GO:0044388 small protein activating enzyme binding;GO:0008641 ubiquitin-like modifier activating enzyme activity", "go_cellular_component": "GO:0031510 SUMO activating enzyme complex;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005634 nucleus", "go_biological_process": "GO:0016925 protein sumoylation;GO:0033235 positive regulation of protein sumoylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VE14-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNS3-1", "uniprot_id": [ { "id": "ABR_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNS3", "type": "external" } ], "mass": 97612.0, "length": 859, "protein_name": "Active breakpoint cluster region-related protein", "gene_name": "ABR", "organism": "Bovine", "refseq_name": "active breakpoint cluster region-related protein", "refseq_ac": [ { "id": "NP_001039669", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039669", "type": "external" } ], "gene_names_uniprotkb": "ABR", "gene_names_refseq": "ABR", "protein_names_uniprotkb": "Active breakpoint cluster region-related protein", "protein_names_refseq": "ABR, RhoGEF and GTPase activating protein; active BCR-related; active breakpoint cluster region-related protein", "tax_id": 9913, "disease": "", "pathway": " (bta:515556); (R-BTA-416482); (R-BTA-8980692); (R-BTA-9013106); (R-BTA-9013148); (R-BTA-9013404); (R-BTA-9013423)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein with a unique structure having two opposing regulatory activities toward small GTP-binding proteins. The C-terminus is a GTPase-activating protein domain which stimulates GTP hydrolysis by RAC1, RAC2 and CDC42. Accelerates the intrinsic rate of GTP hydrolysis of RAC1 or CDC42, leading to down-regulation of the active GTP-bound form. The central Dbl homology (DH) domain functions as guanine nucleotide exchange factor (GEF) that modulates the GTPases CDC42, RHOA and RAC1. Promotes the conversion of CDC42, RHOA and RAC1 from the GDP-bound to the GTP-bound form (By similarity). Functions as an important negative regulator of neuronal RAC1 activity (By similarity). Regulates macrophage functions such as CSF1-directed motility and phagocytosis through the modulation of RAC1 activity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q29RJ4", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0016020 membrane;GO:0030424 axon;GO:0043197 dendritic spine", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0090630 activation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QNS3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBI1-1", "uniprot_id": [ { "id": "ZFP69_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MBI1", "type": "external" } ], "mass": 60808.0, "length": 524, "protein_name": "Zinc finger protein 69 homolog", "gene_name": "ZFP69", "organism": "Bovine", "refseq_name": "zinc finger protein 69 homolog", "refseq_ac": [ { "id": "NP_001095533", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095533", "type": "external" } ], "gene_names_uniprotkb": "ZFP69; ZNF642", "gene_names_refseq": "ZFP69; ZNF642", "protein_names_uniprotkb": "Zinc finger protein 69 homolog; Zinc finger protein 642", "protein_names_refseq": "zinc finger protein 642; zinc finger protein 69 homolog; zinc finger protein ZFP69", "tax_id": 9913, "disease": "", "pathway": " (bta:521549); (R-BTA-212436)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative transcription factor that appears to regulate lipid metabolism., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006629 lipid metabolic process;GO:0019216 regulation of lipid metabolic process;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBI1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLE6-1", "uniprot_id": [ { "id": "ANO4_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLE6", "type": "external" } ], "mass": 107708.0, "length": 920, "protein_name": "Anoctamin-4", "gene_name": "ANO4", "organism": "Bovine", "refseq_name": "anoctamin-4", "refseq_ac": [ { "id": "NP_001095520", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095520", "type": "external" } ], "gene_names_uniprotkb": "ANO4; TMEM16D", "gene_names_refseq": "ANO4; TMEM16D", "protein_names_uniprotkb": "Anoctamin-4; Transmembrane protein 16D", "protein_names_refseq": "anoctamin-4; transmembrane protein 16D", "tax_id": 9913, "disease": "", "pathway": " (bta:518739); (R-BTA-2672351)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0017128 phospholipid scramblase activity;GO:0005229 intracellularly calcium-gated chloride channel activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0045332 phospholipid translocation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLE6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9K3-1", "uniprot_id": [ { "id": "E1B9K3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9K3", "type": "external" } ], "mass": 130103.0, "length": 1166, "protein_name": "Adenylate cyclase type 6", "gene_name": "ADCY6", "organism": "Bovine", "refseq_name": "adenylate cyclase type 6", "refseq_ac": [ { "id": "NP_001137349", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137349", "type": "external" } ], "gene_names_uniprotkb": "ADCY6", "gene_names_refseq": "ADCY6", "protein_names_uniprotkb": "Adenylate cyclase type 6; 4.6.1.1", "protein_names_refseq": "adenylate cyclase type 6", "tax_id": 9913, "disease": "", "pathway": " (bta:509936); (R-BTA-163615); (R-BTA-170660); (R-BTA-170670); (R-BTA-400042); (R-BTA-418597); (R-BTA-5610787)", "pathway_count": 7, "publication_count": 1, "publication_id_list": "15007069", "class_list": "", "function": "Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Co-localization of multiple signaling components in lipid rafts provides key spatial regulation of AC6 (ADCY6) activity., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.1", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.7.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.85", "type": "external" } ], "go_molecular_function": "GO:0004016 adenylate cyclase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0006171 cAMP biosynthetic process;GO:0035556 intracellular signal transduction;GO:0071380 cellular response to prostaglandin E stimulus;GO:0097746 blood vessel diameter maintenance;GO:1904322 cellular response to forskolin", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1B9K3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDU2-1", "uniprot_id": [ { "id": "SIN1_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDU2", "type": "external" } ], "mass": 59125.0, "length": 522, "protein_name": "Target of rapamycin complex 2 subunit MAPKAP1", "gene_name": "MAPKAP1", "organism": "Bovine", "refseq_name": "target of rapamycin complex 2 subunit MAPKAP1", "refseq_ac": [ { "id": "NP_001075072", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075072", "type": "external" } ], "gene_names_uniprotkb": "MAPKAP1; SIN1", "gene_names_refseq": "MAPKAP1", "protein_names_uniprotkb": "Target of rapamycin complex 2 subunit MAPKAP1; Mitogen-activated protein kinase 2-associated protein 1; SAPK-interacting protein 1; Stress-activated map kinase-interacting protein 1", "protein_names_refseq": "SAPK-interacting protein 1; mitogen-activated protein kinase 2-associated protein 1; mitogen-activated protein kinase associated protein 1; stress-activated map kinase-interacting protein 1; target of rapamycin complex 2 subunit MAPKAP1", "tax_id": 9913, "disease": "", "pathway": " (bta:533861)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (By similarity). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (By similarity). In contrast to mTORC1, mTORC2 is nutrient-insensitive (By similarity). Within the mTORC2 complex, MAPKAP1/SIN1 acts as a substrate adapter which recognizes and binds AGC protein kinase family members for phosphorylation by MTOR (By similarity). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (By similarity). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (By similarity). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (By similarity). MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation (By similarity). Inhibits HRAS and KRAS independently of mTORC2 complex (By similarity). Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription (By similarity). Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0019901 protein kinase binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005741 mitochondrial outer membrane;GO:0005769 early endosome", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0032869 cellular response to insulin stimulus;GO:1900407 regulation of cellular response to oxidative stress;GO:0038203 TORC2 signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDU2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLW9-1", "uniprot_id": [ { "id": "RFX2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLW9", "type": "external" } ], "mass": 77673.0, "length": 707, "protein_name": "DNA-binding protein RFX2", "gene_name": "RFX2", "organism": "Bovine", "refseq_name": "DNA-binding protein RFX2", "refseq_ac": [ { "id": "NP_001095642", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095642", "type": "external" } ], "gene_names_uniprotkb": "RFX2", "gene_names_refseq": "RFX2", "protein_names_uniprotkb": "DNA-binding protein RFX2; Regulatory factor X 2", "protein_names_refseq": "DNA-binding protein RFX2; regulatory factor X 2; regulatory factor X, 2 (influences HLA class II expression)", "tax_id": 9913, "disease": "", "pathway": " (bta:534475)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that acts as a key regulator of spermatogenesis. Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function. Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters. Probably activates transcription of the testis-specific histone gene H1-6., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding;GO:1990837 sequence-specific double-stranded DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007286 spermatid development;GO:0060271 cilium assembly;GO:0001675 acrosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLW9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE21-1", "uniprot_id": [ { "id": "COPG2_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE21", "type": "external" } ], "mass": 97565.0, "length": 871, "protein_name": "Coatomer subunit gamma-2", "gene_name": "COPG2", "organism": "Bovine", "refseq_name": "coatomer subunit gamma-2", "refseq_ac": [ { "id": "NP_001075917", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075917", "type": "external" } ], "gene_names_uniprotkb": "COPG2", "gene_names_refseq": "COPG2", "protein_names_uniprotkb": "Coatomer subunit gamma-2; Gamma-2-COP; Gamma-2-coat protein", "protein_names_refseq": "coatomer protein complex subunit gamma 2; coatomer subunit gamma-2; gamma-2-COP; gamma-2-coat protein", "tax_id": 9913, "disease": "", "pathway": " (bta:536616); (R-BTA-6807878); (R-BTA-6811434)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0030426 growth cone;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0009306 protein secretion;GO:0072384 organelle transport along microtubule;GO:0006891 intra-Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VE21-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLP7-1", "uniprot_id": [ { "id": "SSRA_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLP7", "type": "external" } ], "mass": 32054.0, "length": 286, "protein_name": "Translocon-associated protein subunit alpha", "gene_name": "SSR1", "organism": "Bovine", "refseq_name": "translocon-associated protein subunit alpha precursor", "refseq_ac": [ { "id": "NP_001095592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095592", "type": "external" } ], "gene_names_uniprotkb": "SSR1", "gene_names_refseq": "SSR1", "protein_names_uniprotkb": "Translocon-associated protein subunit alpha; SSR-alpha; Signal sequence receptor subunit alpha; TRAP-alpha", "protein_names_refseq": "SSR-alpha; TRAP-alpha; signal sequence receptor subunit alpha; signal sequence receptor, alpha (translocon-associated protein alpha); translocon-associated protein subunit alpha precursor; translocon-associated protein subunit alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:529312)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLP7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUZ6-1", "uniprot_id": [ { "id": "HSDL2_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUZ6", "type": "external" } ], "mass": 45150.0, "length": 418, "protein_name": "Hydroxysteroid dehydrogenase-like protein 2", "gene_name": "HSDL2", "organism": "Bovine", "refseq_name": "hydroxysteroid dehydrogenase-like protein 2", "refseq_ac": [ { "id": "NP_001098433", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098433", "type": "external" } ], "gene_names_uniprotkb": "HSDL2", "gene_names_refseq": "HDLP; HSDL2", "protein_names_uniprotkb": "Hydroxysteroid dehydrogenase-like protein 2; 1.-.-.-", "protein_names_refseq": "hydroxysteroid dehydrogenase-like protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:404131)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Has apparently no steroid dehydrogenase activity. Controls bile acid (BA) and lipid metabolism in response to nutritional cues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A6QPZ9", "ec_number_list": [], "go_molecular_function": "GO:0016491 oxidoreductase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005777 peroxisome", "go_biological_process": "GO:0042632 cholesterol homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUZ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QR09-1", "uniprot_id": [ { "id": "SAMC_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QR09", "type": "external" } ], "mass": 29409.0, "length": 274, "protein_name": "Mitochondrial S-adenosylmethionine carrier protein", "gene_name": "SLC25A26", "organism": "Bovine", "refseq_name": "mitochondrial S-adenosylmethionine carrier protein", "refseq_ac": [ { "id": "NP_001096767", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096767", "type": "external" } ], "gene_names_uniprotkb": "SLC25A26; SAMC", "gene_names_refseq": "SLC25A26", "protein_names_uniprotkb": "Mitochondrial S-adenosylmethionine carrier protein; SAM carrier; Solute carrier family 25 member 26", "protein_names_refseq": "S-adenosylmethionine mitochondrial carrier protein; SAM carrier; mitochondrial S-adenosylmethionine carrier protein; mitochondrial S-adenosylmethionine transporter", "tax_id": 9913, "disease": "", "pathway": " (bta:614713); (R-BTA-549127)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial S-adenosyl-L-methionine/S-adenosyl-L-homocysteine antiporter. Mediates the exchange of cytosolic S-adenosyl-L-methionine, the predominant methyl-group donor for macromolecule methylation processes, for mitochondrial S-adenosylhomocysteine(SAH), a by-product of methylation reactions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000095 S-adenosyl-L-methionine transmembrane transporter activity;GO:0180003 S-adenosyl-L-methionine:S-adenosyl-L-homocysteine antiporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0016020 membrane", "go_biological_process": "GO:0015805 S-adenosyl-L-methionine transport;GO:1990543 mitochondrial S-adenosyl-L-methionine transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QR09-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7E2Z2-1", "uniprot_id": [ { "id": "EZH1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7E2Z2", "type": "external" } ], "mass": 85285.0, "length": 747, "protein_name": "Histone-lysine N-methyltransferase EZH1", "gene_name": "EZH1", "organism": "Bovine", "refseq_name": "histone-lysine N-methyltransferase EZH1", "refseq_ac": [ { "id": "NP_001421973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001421973", "type": "external" } ], "gene_names_uniprotkb": "EZH1", "gene_names_refseq": "EZH1", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase EZH1; 2.1.1.356; Enhancer of zeste homolog 1", "protein_names_refseq": "enhancer of zeste homolog 1; histone-lysine N-methyltransferase EZH1", "tax_id": 9913, "disease": "", "pathway": " (bta:533087); (R-BTA-212300)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.356", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.356", "type": "external" } ], "go_molecular_function": "GO:0003682 chromatin binding;GO:0046976 histone H3K27 methyltransferase activity;GO:0140951 histone H3K27 trimethyltransferase activity;GO:0031491 nucleosome binding;GO:0140693 molecular condensate scaffold activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035098 ESC/E(Z) complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0032259 methylation;GO:0031507 heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7E2Z2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H757-1", "uniprot_id": [ { "id": "PPA6_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H757", "type": "external" } ], "mass": 48945.0, "length": 429, "protein_name": "Lysophosphatidic acid phosphatase type 6", "gene_name": "ACP6", "organism": "Bovine", "refseq_name": "lysophosphatidic acid phosphatase type 6", "refseq_ac": [ { "id": "NP_001092843", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092843", "type": "external" } ], "gene_names_uniprotkb": "ACP6", "gene_names_refseq": "ACP6", "protein_names_uniprotkb": "Lysophosphatidic acid phosphatase type 6; 3.1.3.106", "protein_names_refseq": "lysophosphatidic acid phosphatase protein; lysophosphatidic acid phosphatase type 6", "tax_id": 9913, "disease": "", "pathway": " (bta:515738); (R-BTA-1483166)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "10506173;16717448;19393038", "class_list": "", "function": "Gene mapped by single nucleotide polymorphism., [RefSeq, PubMed]; Hydrolyzes lysophosphatidic acid (LPA) containing a medium length fatty acid chain to the corresponding monoacylglycerol. Has highest activity with lysophosphatidic acid containing myristate (C14:0), monounsaturated oleate (C18:1) or palmitate (C16:0), and lower activity with C18:0 and C6:0 lysophosphatidic acid., [UniProtKB, PubMed, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4", "type": "external" }, { "id": "3.1.3.106", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106", "type": "external" }, { "id": "3.6.1.75", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" } ], "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0003993 acid phosphatase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:2001311 lysobisphosphatidic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A6H757-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7E2-1", "uniprot_id": [ { "id": "TM9S4_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7E2", "type": "external" } ], "mass": 74367.0, "length": 642, "protein_name": "Transmembrane 9 superfamily member 4", "gene_name": "TM9SF4", "organism": "Bovine", "refseq_name": "transmembrane 9 superfamily member 4 precursor", "refseq_ac": [ { "id": "NP_001091546", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091546", "type": "external" } ], "gene_names_uniprotkb": "TM9SF4", "gene_names_refseq": "TM9SF4", "protein_names_uniprotkb": "Transmembrane 9 superfamily member 4", "protein_names_refseq": "transmembrane 9 superfamily member 4 precursor; transmembrane 9 superfamily protein member 4", "tax_id": 9913, "disease": "", "pathway": " (bta:533562)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:2000010 positive regulation of protein localization to cell surface;GO:0001666 response to hypoxia;GO:0006909 phagocytosis;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7E2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B841-1", "uniprot_id": [ { "id": "E1B841_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B841", "type": "external" } ], "mass": 82421.0, "length": 761, "protein_name": "Forkhead box protein M1", "gene_name": "FOXM1", "organism": "Bovine", "refseq_name": "forkhead box protein M1 isoform X1", "refseq_ac": [ { "id": "XP_002687946", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002687946", "type": "external" } ], "gene_names_uniprotkb": "FOXM1", "gene_names_refseq": "FOXM1", "protein_names_uniprotkb": "Forkhead box protein M1", "protein_names_refseq": "forkhead box protein M1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:513643); (R-BTA-156711); (R-BTA-69273)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Also plays a role in DNA break repair, participating in the DNA damage checkpoint response. Promotes transcription of PHB2., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding;GO:0019901 protein kinase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus", "go_biological_process": "GO:0000086 G2/M transition of mitotic cell cycle;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0008284 positive regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B841-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H769-1", "uniprot_id": [ { "id": "RS7_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H769", "type": "external" } ], "mass": 22127.0, "length": 194, "protein_name": "Small ribosomal subunit protein eS7", "gene_name": "RPS7", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein eS7", "refseq_ac": [ { "id": "NP_001092344", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092344", "type": "external" } ], "gene_names_uniprotkb": "RPS7", "gene_names_refseq": "RPS7", "protein_names_uniprotkb": "Small ribosomal subunit protein eS7; 40S ribosomal protein S7", "protein_names_refseq": "40S ribosomal protein S7; small ribosomal subunit protein eS7", "tax_id": 9913, "disease": "", "pathway": " (bta:505507); (R-BTA-156827); (R-BTA-1799339); (R-BTA-6791226); (R-BTA-72649); (R-BTA-72689); (R-BTA-72695); (R-BTA-72702); (R-BTA-72706); (R-BTA-975956); (R-BTA-975957); (R-BTA-9954714); (R-BTA-9954716)", "pathway_count": 13, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for rRNA maturation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0019901 protein kinase binding;GO:0003730 mRNA 3'-UTR binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0048027 mRNA 5'-UTR binding", "go_cellular_component": "GO:0005813 centrosome;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit;GO:0045202 synapse", "go_biological_process": "GO:0006412 translation;GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process;GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H769-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4K8-1", "uniprot_id": [ { "id": "U2AF1_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4K8", "type": "external" } ], "mass": 27701.0, "length": 237, "protein_name": "Splicing factor U2AF 35 kDa subunit", "gene_name": "U2AF1", "organism": "Bovine", "refseq_name": "splicing factor U2AF 35 kDa subunit", "refseq_ac": [ { "id": "NP_001073737", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073737", "type": "external" } ], "gene_names_uniprotkb": "U2AF1", "gene_names_refseq": "U2AF1", "protein_names_uniprotkb": "Splicing factor U2AF 35 kDa subunit; U2 auxiliary factor 35 kDa subunit; U2 snRNP auxiliary factor small subunit", "protein_names_refseq": "U2 auxiliary factor 35 kDa subunit; U2 snRNP auxiliary factor small subunit; splicing factor U2AF 35 kDa subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:512680); (R-BTA-159236); (R-BTA-72163); (R-BTA-9770562)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0030628 pre-mRNA 3'-splice site binding;GO:0003723 RNA binding;GO:0050733 RS domain binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0005681 spliceosomal complex;GO:0089701 U2AF complex;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4K8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBJ2-1", "uniprot_id": [ { "id": "SENP7_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MBJ2", "type": "external" } ], "mass": 118889.0, "length": 1047, "protein_name": "Sentrin-specific protease 7", "gene_name": "SENP7", "organism": "Bovine", "refseq_name": "sentrin-specific protease 7", "refseq_ac": [ { "id": "NP_001095358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095358", "type": "external" } ], "gene_names_uniprotkb": "SENP7; SUSP2", "gene_names_refseq": "SENP7", "protein_names_uniprotkb": "Sentrin-specific protease 7; 3.4.22.-; SUMO-1-specific protease 2; Sentrin/SUMO-specific protease SENP7", "protein_names_refseq": "SUMO-1-specific protease 2; SUMO1/sentrin specific peptidase 7; sentrin-specific protease 7-like; sentrin-specific protease 7; sentrin/SUMO-specific protease 7; sentrin/SUMO-specific protease SENP7", "tax_id": 9913, "disease": "", "pathway": " (bta:507820)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protease that acts as a positive regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS. Desumoylation of CGAS promotes DNA-binding activity of CGAS, subsequent oligomerization and activation (By similarity). Deconjugates SUMO2 and SUMO3 from targeted proteins, but not SUMO1. Catalyzes the deconjugation of poly-SUMO2 and poly-SUMO3 chains. Has very low efficiency in processing full-length SUMO proteins to their mature forms (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070139 SUMO-specific endopeptidase activity;GO:0008234 cysteine-type peptidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0099523 presynaptic cytosol;GO:0099524 postsynaptic cytosol", "go_biological_process": "GO:0006508 proteolysis;GO:0016926 protein desumoylation;GO:0140374 antiviral innate immune response;GO:0045087 innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBJ2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BAL6-1", "uniprot_id": [ { "id": "E1BAL6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BAL6", "type": "external" } ], "mass": 186647.0, "length": 1649, "protein_name": "eIF-2-alpha kinase GCN2", "gene_name": "EIF2AK4", "organism": "Bovine", "refseq_name": "eIF-2-alpha kinase GCN2 isoform X2", "refseq_ac": [ { "id": "XP_002690831", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002690831", "type": "external" } ], "gene_names_uniprotkb": "EIF2AK4", "gene_names_refseq": "EIF2AK4", "protein_names_uniprotkb": "eIF-2-alpha kinase GCN2; 2.7.11.1; Eukaryotic translation initiation factor 2-alpha kinase 4; GCN2-like protein", "protein_names_refseq": "eIF-2-alpha kinase GCN2 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:513829)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0005524 ATP binding;GO:0000049 tRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0007399 nervous system development;GO:0034198 cellular response to amino acid starvation;GO:0000077 DNA damage checkpoint signaling;GO:0140469 GCN2-mediated signaling;GO:0070417 cellular response to cold", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BAL6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B8J7-1", "uniprot_id": [ { "id": "E1B8J7_BOVIN", "url": 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"id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:1990604 IRE1-TRAF2-ASK1 complex;GO:0005783 endoplasmic reticulum;GO:0044322 endoplasmic reticulum quality control compartment", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006397 mRNA processing;GO:0006355 regulation of DNA-templated transcription;GO:0006915 apoptotic process;GO:0030968 endoplasmic reticulum unfolded protein response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B8J7-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLI8-1", "uniprot_id": [ { "id": "T2EA_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLI8", "type": "external" } ], "mass": 49211.0, "length": 438, "protein_name": "General transcription factor IIE subunit 1", "gene_name": "GTF2E1", "organism": "Bovine", "refseq_name": "general transcription factor IIE subunit 1", "refseq_ac": [ { "id": "NP_001096764", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096764", "type": "external" } ], "gene_names_uniprotkb": "GTF2E1", "gene_names_refseq": "GTF2E1", "protein_names_uniprotkb": "General transcription factor IIE subunit 1; TFIIE-alpha; Transcription initiation factor IIE subunit alpha", "protein_names_refseq": "TFIIE-alpha; general transcription factor IIE subunit 1; general transcription factor IIE, polypeptide 1, alpha 56kDa; transcription initiation factor IIE subunit alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:540525); (R-BTA-674695); (R-BTA-6807505); (R-BTA-73776); (R-BTA-73779); (R-BTA-75953); (R-BTA-76042)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016251 RNA polymerase II general transcription initiation factor activity", "go_cellular_component": "GO:0005673 transcription factor TFIIE complex;GO:0005669 transcription factor TFIID complex", "go_biological_process": "GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0051123 RNA polymerase II preinitiation complex assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLI8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7E316-1", "uniprot_id": [ { "id": "PACER_BOVIN", "url": "https://www.uniprot.org/uniprot/A7E316", "type": "external" } ], "mass": 73604.0, "length": 663, "protein_name": "Protein associated with UVRAG as autophagy enhancer", "gene_name": "RUBCNL", "organism": "Bovine", "refseq_name": "protein associated with UVRAG as autophagy enhancer", "refseq_ac": [ { "id": "NP_001095511", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095511", "type": "external" } ], "gene_names_uniprotkb": "RUBCNL", "gene_names_refseq": "C12H13orf18; KIAA0226L; RUBCNL", "protein_names_uniprotkb": "Protein associated with UVRAG as autophagy enhancer; Pacer; Protein Rubicon-like", "protein_names_refseq": "KIAA0226-like ortholog; RUN and cysteine rich domain containing beclin 1 interacting protein like; Uncharacterized protein C13orf18 homolog; pacer; protein RUBCNL-like; protein Rubicon-like; protein associated with UVRAG as autophagy enhancer; rubicon like autophagy regulator", "tax_id": 9913, "disease": "", "pathway": " (bta:517231)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy. Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex. Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes. Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (By similarity). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding;GO:0070273 phosphatidylinositol-4-phosphate binding;GO:1901981 phosphatidylinositol phosphate binding;GO:0032266 phosphatidylinositol-3-phosphate binding", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0097352 autophagosome maturation;GO:0006629 lipid metabolic process;GO:0019216 regulation of lipid metabolic process;GO:0061909 autophagosome-lysosome fusion;GO:0061910 autophagosome-endosome fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7E316-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDM0-1", "uniprot_id": [ { "id": "TIFA_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDM0", "type": "external" } ], "mass": 21579.0, "length": 185, "protein_name": "TRAF-interacting protein with FHA domain-containing protein A", "gene_name": "TIFA", "organism": "Bovine", "refseq_name": "TRAF-interacting protein with FHA domain-containing protein A", "refseq_ac": [ { "id": "NP_001075090", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075090", "type": "external" } ], "gene_names_uniprotkb": "TIFA", "gene_names_refseq": "TIFA", "protein_names_uniprotkb": "TRAF-interacting protein with FHA domain-containing protein A", "protein_names_refseq": "TRAF-interacting protein with FHA domain-containing protein A; TRAF2-binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:783855); (R-BTA-445989); (R-BTA-9645460)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism. TIFA-dependent innate immune response is triggered by ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria: ADP-Heptose is recognized by ALPK1, which phosphorylates TIFA at Thr-9, leading to TIFA homooligomerization and subsequent activation of pro-inflammatory NF-kappa-B signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0051260 protein homooligomerization;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0002753 cytoplasmic pattern recognition receptor signaling pathway;GO:0033209 tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDM0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4J8-1", "uniprot_id": [ { "id": "SCO1_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4J8", "type": "external" } ], "mass": 33658.0, "length": 305, "protein_name": "Cytochrome c oxidase assembly factor SCO1", "gene_name": "SCO1", "organism": "Bovine", "refseq_name": "cytochrome c oxidase assembly factor SCO1 precursor", "refseq_ac": [ { "id": "NP_001073712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073712", "type": "external" } ], "gene_names_uniprotkb": "SCO1; SCOD1", "gene_names_refseq": "SCO1", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor SCO1", "protein_names_refseq": "SCO cytochrome c oxidase assembly protein 1; SCO cytochrome oxidase deficient homolog 1; SCO1, cytochrome c oxidase assembly protein; cytochrome c oxidase assembly factor SCO1 precursor; cytochrome c oxidase assembly factor SCO1; protein SCO1 homolog, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:508586); (R-BTA-9864848)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Together with SCO2, involved in delivering copper to the Cu(A) site on MT-CO2/COX2. Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0030016 myofibril", "go_biological_process": "GO:0033617 mitochondrial respiratory chain complex IV assembly;GO:0008535 respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4J8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7Z1-1", "uniprot_id": [ { "id": "E1B7Z1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7Z1", "type": "external" } ], "mass": 122774.0, "length": 1109, "protein_name": "ArfGAP with SH3 domain, ankyrin repeat and PH domain 1", "gene_name": "ASAP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ASAP1", "gene_names_refseq": "", "protein_names_uniprotkb": "ArfGAP with SH3 domain, ankyrin repeat and PH domain 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "E1BBN8", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0000139 Golgi membrane;GO:0032588 trans-Golgi network membrane", "go_biological_process": "GO:0060271 cilium assembly;GO:0061512 protein localization to cilium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7Z1-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB35-1", "uniprot_id": [ { "id": "ODPA_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB35", "type": "external" } ], "mass": 43388.0, "length": 390, "protein_name": "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial", "gene_name": "PDHA1", "organism": "Bovine", "refseq_name": "pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001094516", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094516", "type": "external" } ], "gene_names_uniprotkb": "PDHA1", "gene_names_refseq": "PDHA1; PDHA", "protein_names_uniprotkb": "Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; 1.2.4.1; PDHE1-A type I", "protein_names_refseq": "PDHE1-A type I; pyruvate dehydrogenase (lipoamide) alpha 1; pyruvate dehydrogenase E1 alpha 1 subunit; pyruvate dehydrogenase E1 component alpha subunit; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor; pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; pyruvate dehydrogenase alpha 1", "tax_id": 9913, "disease": "", "pathway": " (bta:407109); (R-BTA-204174); (R-BTA-5362517); (R-BTA-9837999); (R-BTA-9861559)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)., [UniProtKB, UniProtKB, UniProtKB]; Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex. The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35", "type": "external" }, { "id": "5.3.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.3.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.37", "type": "external" }, { "id": "1.2.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.1", "type": "external" }, { "id": "5.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.8", "type": "external" }, { "id": "2.3.1.41", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "1.8.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.4", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.3.43", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.43", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "7.1.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.2", "type": "external" }, { "id": "1.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.3", "type": "external" }, { "id": "4.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3", "type": "external" }, { "id": "4.98.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.98.1.1", "type": "external" }, { "id": "1.1.1.30", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30", "type": "external" }, { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "1.3.8.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5", "type": "external" }, { "id": "1.2.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.4.2", "type": "external" }, { "id": "2.3.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1", "type": "external" }, { "id": "2.3.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9", "type": "external" }, { "id": "3.4.21.92", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.92", "type": "external" }, { "id": "1.1.1.37", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity;GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045254 pyruvate dehydrogenase complex", "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006006 glucose metabolic process;GO:0006086 pyruvate decarboxylation to acetyl-CoA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB35-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4L0-1", "uniprot_id": [ { "id": "SNX4_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4L0", "type": "external" } ], "mass": 52194.0, "length": 450, "protein_name": "Sorting nexin-4", "gene_name": "SNX4", "organism": "Bovine", "refseq_name": "sorting nexin-4", "refseq_ac": [ { "id": "NP_001073750", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073750", "type": "external" } ], "gene_names_uniprotkb": "SNX4", "gene_names_refseq": "SNX4", "protein_names_uniprotkb": "Sorting nexin-4", "protein_names_refseq": "sorting nexin-4", "tax_id": 9913, "disease": "", "pathway": " (bta:519597)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding;GO:0005158 insulin receptor binding;GO:0005154 epidermal growth factor receptor binding;GO:1990460 leptin receptor binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0031901 early endosome membrane;GO:0005868 cytoplasmic dynein complex;GO:0031201 SNARE complex", "go_biological_process": "GO:0015031 protein transport;GO:0032456 endocytic recycling;GO:2000786 positive regulation of autophagosome assembly;GO:1903595 positive regulation of histamine secretion by mast cell", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4L0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9E6-1", "uniprot_id": [ { "id": "E1B9E6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9E6", "type": "external" } ], "mass": 77758.0, "length": 686, "protein_name": "TRAF3-interacting protein 1", "gene_name": "TRAF3IP1", "organism": "Bovine", "refseq_name": "TRAF3-interacting protein 1", "refseq_ac": [ { "id": "NP_001178973", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178973", "type": "external" } ], "gene_names_uniprotkb": "TRAF3IP1", "gene_names_refseq": "TRAF3IP1", "protein_names_uniprotkb": "TRAF3-interacting protein 1; Intraflagellar transport protein 54 homolog; Microtubule-interacting protein associated with TRAF3", "protein_names_refseq": "TNF receptor-associated factor 3 interacting protein 1; TRAF3-interacting protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:504984); (R-BTA-5620924)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005930 axoneme;GO:0030992 intraciliary transport particle B;GO:0005813 centrosome;GO:0036064 ciliary basal body;GO:0097546 ciliary base", "go_biological_process": "GO:0048731 system development;GO:0001738 morphogenesis of a polarized epithelium;GO:0030030 cell projection organization;GO:0048513 animal organ development;GO:0070507 regulation of microtubule cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9E6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLG5-1", "uniprot_id": [ { "id": "RS9_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLG5", "type": "external" } ], "mass": 22591.0, "length": 194, "protein_name": "Small ribosomal subunit protein uS4", "gene_name": "RPS9", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein uS4", "refseq_ac": [ { "id": "NP_001094622", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094622", "type": "external" } ], "gene_names_uniprotkb": "RPS9", "gene_names_refseq": "RPS9", "protein_names_uniprotkb": "Small ribosomal subunit protein uS4; 40S ribosomal protein S9", "protein_names_refseq": "40S ribosomal protein S9; small ribosomal subunit protein uS4", "tax_id": 9913, "disease": "", "pathway": " (bta:533892); (R-BTA-156827); (R-BTA-1799339); (R-BTA-6791226); (R-BTA-72649); (R-BTA-72689); (R-BTA-72695); (R-BTA-72702); (R-BTA-72706); (R-BTA-975956); (R-BTA-975957); (R-BTA-9954714); (R-BTA-9954716)", "pathway_count": 13, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019843 rRNA binding;GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:1990904 ribonucleoprotein complex;GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit;GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0006412 translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLG5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFJ6-1", "uniprot_id": [ { "id": "IKZF5_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFJ6", "type": "external" } ], "mass": 46541.0, "length": 419, "protein_name": "Zinc finger protein Pegasus", "gene_name": "IKZF5", "organism": "Bovine", "refseq_name": "zinc finger protein Pegasus", "refseq_ac": [ { "id": "NP_001077182", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077182", "type": "external" } ], "gene_names_uniprotkb": "IKZF5", "gene_names_refseq": "IKZF5", "protein_names_uniprotkb": "Zinc finger protein Pegasus; Ikaros family zinc finger protein 5", "protein_names_refseq": "IKAROS family zinc finger 5 (Pegasus); ikaros family zinc finger protein 5; zinc finger protein Pegasus", "tax_id": 9913, "disease": "", "pathway": " (bta:531250)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence (By similarity). Involved in megakaryocyte differentiation (By similarity)., [UniProtKB, UniProtKB]; Transcriptional repressor that binds the core 5'GNNTGTNG-3' DNA consensus sequence. Involved in megakaryocyte differentiation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFJ6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BA71-1", "uniprot_id": [ { "id": "E1BA71_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BA71", "type": "external" } ], "mass": 81750.0, "length": 721, "protein_name": "Transmembrane channel-like protein", "gene_name": "TMC8", "organism": "Bovine", "refseq_name": "transmembrane channel-like protein 8", "refseq_ac": [ { "id": "XP_002696205", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696205", "type": "external" } ], "gene_names_uniprotkb": "TMC8", "gene_names_refseq": "TMC8", "protein_names_uniprotkb": "Transmembrane channel-like protein", "protein_names_refseq": "transmembrane channel-like protein 8", "tax_id": 9913, "disease": "", "pathway": " (bta:513813)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043120 tumor necrosis factor binding;GO:0008381 mechanosensitive monoatomic ion channel activity;GO:0140311 protein sequestering activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0031965 nuclear membrane", "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0050821 protein stabilization;GO:0043124 negative regulation of canonical NF-kappaB signal transduction;GO:0031333 negative regulation of protein-containing complex assembly;GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BA71-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7H1-1", "uniprot_id": [ { "id": "S39AD_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7H1", "type": "external" } ], "mass": 44432.0, "length": 423, "protein_name": "Zinc transporter ZIP13", "gene_name": "SLC39A13", "organism": "Bovine", "refseq_name": "zinc transporter ZIP13 precursor", "refseq_ac": [ { "id": "NP_001091601", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091601", "type": "external" } ], "gene_names_uniprotkb": "SLC39A13; ZIP13", "gene_names_refseq": "SLC39A13", "protein_names_uniprotkb": "Zinc transporter ZIP13; Solute carrier family 39 member 13; ZIP-13; Zrt- and Irt-like protein 13", "protein_names_refseq": "ZIP-13; solute carrier family 39 (zinc transporter), member 13; zinc transporter ZIP13 precursor; zinc transporter ZIP13; zrt- and Irt-like protein 13", "tax_id": 9913, "disease": "", "pathway": " (bta:614946)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a zinc transporter transporting Zn(2+) from the Golgi apparatus to the cytosol and thus influences the zinc level at least in areas of the cytosol. May regulate beige adipocyte differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0046873 metal ion transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0030659 cytoplasmic vesicle membrane", "go_biological_process": "GO:0071577 zinc ion transmembrane transport;GO:0006829 zinc ion transport;GO:0050873 brown fat cell differentiation;GO:0006882 intracellular zinc ion homeostasis;GO:0061448 connective tissue development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7H1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B770-1", "uniprot_id": [ { "id": "E1B770_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B770", "type": "external" } ], "mass": 59088.0, "length": 530, "protein_name": "Lysophosphatidylcholine acyltransferase 2", "gene_name": "LPCAT2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LPCAT2", "gene_names_refseq": "", "protein_names_uniprotkb": "Lysophosphatidylcholine acyltransferase 2; 1-acylglycerol-3-phosphate O-acyltransferase 11; 1-acylglycerophosphocholine O-acyltransferase; 1-alkenylglycerophosphocholine O-acyltransferase; 1-alkylglycerophosphocholine O-acetyltransferase; 2.3.1.23; 2.3.1.25; 2.3.1.51; 2.3.1.67; Acetyl-CoA:lyso-platelet-activating factor acetyltransferase; Acyltransferase-like 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1482788)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "3.1.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "2.3.1.67", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67", "type": "external" }, { "id": "2.3.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25", "type": "external" }, { "id": "2.3.1.n6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6", "type": "external" }, { "id": "2.3.1.n7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" } ], "go_molecular_function": "GO:0042171 lysophosphatidic acid acyltransferase activity;GO:0005509 calcium ion binding;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0047192 1-alkylglycerophosphocholine O-acetyltransferase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005811 lipid droplet;GO:0005789 endoplasmic reticulum membrane;GO:0005795 Golgi stack", "go_biological_process": "GO:0008654 phospholipid biosynthetic process;GO:0006663 platelet activating factor biosynthetic process;GO:0061024 membrane organization;GO:0036151 phosphatidylcholine acyl-chain remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B770-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7V5-1", "uniprot_id": [ { "id": "MO2R1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7V5", "type": "external" } ], "mass": 39220.0, "length": 355, "protein_name": "Cell surface glycoprotein CD200 receptor 1", "gene_name": "CD200R1; LOC516008", "organism": "Bovine", "refseq_name": "cell surface glycoprotein CD200 receptor 1 precursor", "refseq_ac": [ { "id": "NP_001092844", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092844", "type": "external" } ], "gene_names_uniprotkb": "CD200R1; LOC516008; CD200R", "gene_names_refseq": "CD200R1; CD200R2; LOC516008", "protein_names_uniprotkb": "Cell surface glycoprotein CD200 receptor 1; CD200 cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1", "protein_names_refseq": "CD200 cell surface glycoprotein receptor; cell surface glycoprotein CD200 receptor 1 precursor; cell surface glycoprotein CD200 receptor 1; cell surface glycoprotein OX2 receptor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:516008); (R-BTA-198933)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0150077 regulation of neuroinflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7V5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H7B5-1", "uniprot_id": [ { "id": "CSN3_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H7B5", "type": "external" } ], "mass": 47799.0, "length": 423, "protein_name": "COP9 signalosome complex subunit 3", "gene_name": "COPS3", "organism": "Bovine", "refseq_name": "COP9 signalosome complex subunit 3", "refseq_ac": [ { "id": "NP_001092374", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092374", "type": "external" } ], "gene_names_uniprotkb": "COPS3; CSN3", "gene_names_refseq": "COPS3", "protein_names_uniprotkb": "COP9 signalosome complex subunit 3; SGN3; Signalosome subunit 3", "protein_names_refseq": "COP9 constitutive photomorphogenic homolog subunit 3; COP9 signalosome complex subunit 3; SGN3; signalosome subunit 3", "tax_id": 9913, "disease": "", "pathway": " (bta:507932); (R-BTA-5696394); (R-BTA-6781823); (R-BTA-8856825); (R-BTA-8951664)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo (By similarity). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (By similarity). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0048471 perinuclear region of cytoplasm;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0000338 protein deneddylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H7B5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQX5-1", "uniprot_id": [ { "id": "TRI44_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQX5", "type": "external" } ], "mass": 37512.0, "length": 338, "protein_name": "Tripartite motif-containing protein 44", "gene_name": "TRIM44", "organism": "Bovine", "refseq_name": "tripartite motif-containing protein 44", "refseq_ac": [ { "id": "NP_001098484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098484", "type": "external" } ], "gene_names_uniprotkb": "TRIM44", "gene_names_refseq": "DIPB; TRIM44", "protein_names_uniprotkb": "Tripartite motif-containing protein 44", "protein_names_refseq": "tripartite motif-containing protein 44", "tax_id": 9913, "disease": "", "pathway": " (bta:782816)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in the process of differentiation and maturation of neuronal cells (By similarity). May regulate the activity of TRIM17 (By similarity). Is a negative regulator of PAX6 expression (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0045087 innate immune response;GO:0050821 protein stabilization;GO:0010468 regulation of gene expression;GO:0001961 positive regulation of cytokine-mediated signaling pathway;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQX5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLU1-1", "uniprot_id": [ { "id": "GPDM_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLU1", "type": "external" } ], "mass": 80763.0, "length": 727, "protein_name": "Glycerol-3-phosphate dehydrogenase, mitochondrial", "gene_name": "GPD2", "organism": "Bovine", "refseq_name": "glycerol-3-phosphate dehydrogenase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001093766", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093766", "type": "external" } ], "gene_names_uniprotkb": "GPD2", "gene_names_refseq": "GPD-M; GPD2; GPDH-M", "protein_names_uniprotkb": "Glycerol-3-phosphate dehydrogenase, mitochondrial; 1.1.5.3; GPD-M; GPDH-M", "protein_names_refseq": "Glycerol-3-phosphate dehydrogenase, mitochondrial; glycerol-3-phosphate dehydrogenase 2 (mitochondrial); glycerol-3-phosphate dehydrogenase, mitochondrial precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:504948); (R-BTA-1483166); (R-BTA-163560)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.5.3", "type": "external" } ], "go_molecular_function": "GO:0004368 glycerol-3-phosphate dehydrogenase (quinone) activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0019563 glycerol catabolic process;GO:0006127 glycerol-3-phosphate shuttle;GO:0006072 glycerol-3-phosphate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLU1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV57-1", "uniprot_id": [ { "id": "AEBP2_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV57", "type": "external" } ], "mass": 54049.0, "length": 511, "protein_name": "Zinc finger protein AEBP2", "gene_name": "AEBP2", "organism": "Bovine", "refseq_name": "zinc finger protein AEBP2", "refseq_ac": [ { "id": "NP_001076954", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076954", "type": "external" } ], "gene_names_uniprotkb": "AEBP2", "gene_names_refseq": "AEBP2", "protein_names_uniprotkb": "Zinc finger protein AEBP2; AE-binding protein 2; Adipocyte enhancer-binding protein 2", "protein_names_refseq": "adipocyte enhancer-binding protein 2; zinc finger protein AEBP2", "tax_id": 9913, "disease": "", "pathway": " (bta:537791); (R-BTA-212300); (R-BTA-3214841)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene. Plays a role in nucleosome localization of the PRC2 complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0035098 ESC/E(Z) complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006325 chromatin organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV57-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7S3-1", "uniprot_id": [ { "id": "TRM1L_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7S3", "type": "external" } ], "mass": 81813.0, "length": 737, "protein_name": "tRNA (guanine(27)-N(2))-dimethyltransferase", "gene_name": "TRMT1L", "organism": "Bovine", "refseq_name": "tRNA (guanine(27)-N(2))-dimethyltransferase", "refseq_ac": [ { "id": "NP_001091590", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091590", "type": "external" } ], "gene_names_uniprotkb": "TRMT1L", "gene_names_refseq": "TRM1L; TRMT1L", "protein_names_uniprotkb": "tRNA (guanine(27)-N(2))-dimethyltransferase; 2.1.1.-; TRMT1-like protein; tRNA methyltransferase 1-like protein", "protein_names_refseq": "TRM1 tRNA methyltransferase 1-like; TRM1-like protein; TRMT1-like protein; tRNA (guanine(27)-N(2))-dimethyltransferase; tRNA methyltransferase 1 homolog-like; tRNA methyltransferase 1-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:540872)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups. Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons. Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs., [UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016423 tRNA (guanine) methyltransferase activity;GO:0008270 zinc ion binding;GO:0000049 tRNA binding;GO:0160248 tRNA (guanine(27)-N2)-dimethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0008033 tRNA processing;GO:0032259 methylation;GO:0002940 tRNA N2-guanine methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7S3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BA41-1", "uniprot_id": [ { "id": "E1BA41_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BA41", "type": "external" } ], "mass": 124845.0, "length": 1116, "protein_name": "Lysine-specific demethylase 4B", "gene_name": "KDM4B", "organism": "Bovine", "refseq_name": "lysine-specific demethylase 4B isoform X1", "refseq_ac": [ { "id": "XP_059744635", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059744635", "type": "external" } ], "gene_names_uniprotkb": "KDM4B", "gene_names_refseq": "KDM4B", "protein_names_uniprotkb": "Lysine-specific demethylase 4B; 1.14.11.66; JmjC domain-containing histone demethylation protein 3B; Jumonji domain-containing protein 2B; [histone H3]-trimethyl-L-lysine(9) demethylase 4B", "protein_names_refseq": "lysine-specific demethylase 4B isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:508141); (R-BTA-3214842); (R-BTA-5693565); (R-BTA-9018519)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate. Plays a critical role in the development of the central nervous system (CNS)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "1.14.11.79", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.79", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140684 histone H3K9me2/H3K9me3 demethylase activity;GO:0051864 histone H3K36 demethylase activity;GO:0032454 histone H3K9 demethylase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0005721 pericentric heterochromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006338 chromatin remodeling;GO:0007420 brain development;GO:0010468 regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BA41-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDK6-1", "uniprot_id": [ { "id": "WASF2_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDK6", "type": "external" } ], "mass": 54031.0, "length": 493, "protein_name": "Actin-binding protein WASF2", "gene_name": "WASF2", "organism": "Bovine", "refseq_name": "actin-binding protein WASF2", "refseq_ac": [ { "id": "NP_001074980", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074980", "type": "external" } ], "gene_names_uniprotkb": "WASF2", "gene_names_refseq": "WASF2", "protein_names_uniprotkb": "Actin-binding protein WASF2; WASP family protein member 2; Wiskott-Aldrich syndrome protein family member 2", "protein_names_refseq": "WAS protein family member 2; WASP family protein member 2; actin-binding protein WASF2; wiskott-Aldrich syndrome protein family member 2", "tax_id": 9913, "disease": "", "pathway": " (bta:504482); (R-BTA-2029482); (R-BTA-5663213); (R-BTA-9013404); (R-BTA-9013423)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0017124 SH3 domain binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005856 cytoskeleton;GO:0005911 cell-cell junction;GO:0016323 basolateral plasma membrane;GO:0030027 lamellipodium", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation;GO:0098974 postsynaptic actin cytoskeleton organization;GO:0010592 positive regulation of lamellipodium assembly;GO:0051497 negative regulation of stress fiber assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDK6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7A6-1", "uniprot_id": [ { "id": "E1B7A6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7A6", "type": "external" } ], "mass": 59747.0, "length": 556, "protein_name": "Choline/ethanolamine transporter FLVCR1", "gene_name": "FLVCR1", "organism": "Bovine", "refseq_name": "choline/ethanolamine transporter FLVCR1", "refseq_ac": [ { "id": "NP_001192948", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192948", "type": "external" } ], "gene_names_uniprotkb": "FLVCR1", "gene_names_refseq": "FLVCR1", "protein_names_uniprotkb": "Choline/ethanolamine transporter FLVCR1; Heme transporter FLVCR1", "protein_names_refseq": "choline/ethanolamine transporter FLVCR1; feline leukemia virus subgroup C cellular receptor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:533317); (R-BTA-189451); (R-BTA-917937)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "30642591", "class_list": "", "function": "This is the first time that FLVCR expression has been investigated in bovine tissues and the first to suggest that expression could be increased in cancers., [RefSeq, PubMed]; Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis. Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids. Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane. Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0015232 heme transmembrane transporter activity;GO:0020037 heme binding;GO:0015220 choline transmembrane transporter activity;GO:0034228 ethanolamine transmembrane transporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0031966 mitochondrial membrane;GO:0005739 mitochondrion;GO:0016020 membrane", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0006783 heme biosynthetic process;GO:0006839 mitochondrial transport;GO:0030218 erythrocyte differentiation;GO:0008654 phospholipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1B7A6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLI2-1", "uniprot_id": [ { "id": "SCG3_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLI2", "type": "external" } ], "mass": 53751.0, "length": 471, "protein_name": "Secretogranin-3", "gene_name": "SCG3", "organism": "Bovine", "refseq_name": "secretogranin-3 precursor", "refseq_ac": [ { "id": "NP_001095567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095567", "type": "external" } ], "gene_names_uniprotkb": "SCG3", "gene_names_refseq": "SCG3; SgIII", "protein_names_uniprotkb": "Secretogranin-3; Secretogranin III; SgIII", "protein_names_refseq": "secretogranin-3 precursor; secretogranin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:525941); (R-BTA-114608); (R-BTA-381426); (R-BTA-8957275)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Member of the granin protein family that regulates the biogenesis of secretory granules (By similarity). Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA (By similarity). May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 2, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "F1MY56", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0030658 transport vesicle membrane;GO:0030667 secretory granule membrane", "go_biological_process": "GO:0033366 protein localization to secretory granule", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QLI2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B8G1-1", "uniprot_id": [ { "id": "E1B8G1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B8G1", "type": "external" } ], "mass": 70696.0, "length": 653, "protein_name": "Protein numb homolog", "gene_name": "NUMB", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "NUMB", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein numb homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5610780); (R-BTA-5632684)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the process of neurogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0045294 alpha-catenin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0005905 clathrin-coated pit", "go_biological_process": "GO:0007399 nervous system development;GO:0050769 positive regulation of neurogenesis;GO:0030335 positive regulation of cell migration;GO:1903077 negative regulation of protein localization to plasma membrane;GO:0021670 lateral ventricle development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B8G1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VEA7-1", "uniprot_id": [ { "id": "DAPL1_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VEA7", "type": "external" } ], "mass": 11821.0, "length": 107, "protein_name": "Death-associated protein-like 1", "gene_name": "DAPL1", "organism": "Bovine", "refseq_name": "death-associated protein-like 1", "refseq_ac": [ { "id": "NP_001020517", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001020517", "type": "external" } ], "gene_names_uniprotkb": "DAPL1; EEDA", "gene_names_refseq": "DAPL1; EEDA", "protein_names_uniprotkb": "Death-associated protein-like 1; Early epithelial differentiation-associated protein", "protein_names_refseq": "death-associated protein-like 1; early epithelial differentiation-associated protein", "tax_id": 9913, "disease": "", "pathway": " (bta:574085)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "15920738", "class_list": "", "function": "May play a role in the early stages of epithelial differentiation or in apoptosis., [UniProtKB, PubMed]; Results indicate that early epithelial differentiation associated (EEDA) is involved in the early stages of normal epithelial differentiation, and that EEDA is important for the 'normal' differentiation pathway in a wide range of stratified epithelia., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q4PP00", "ec_number_list": [], "go_molecular_function": "GO:0030371 translation repressor activity;GO:0043022 ribosome binding;GO:0031369 translation initiation factor binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0030154 cell differentiation;GO:0097190 apoptotic signaling pathway;GO:0010507 negative regulation of autophagy;GO:2001186 negative regulation of CD8-positive, alpha-beta T cell activation;GO:0141014 ribosome hibernation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2VEA7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PKG7-1", "uniprot_id": [ { "id": "KCTD5_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PKG7", "type": "external" } ], "mass": 25986.0, "length": 234, "protein_name": "BTB/POZ domain-containing protein KCTD5", "gene_name": "KCTD5", "organism": "Bovine", "refseq_name": "BTB/POZ domain-containing protein KCTD5", "refseq_ac": [ { "id": "NP_001096811", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096811", "type": "external" } ], "gene_names_uniprotkb": "KCTD5", "gene_names_refseq": "KCTD5", "protein_names_uniprotkb": "BTB/POZ domain-containing protein KCTD5", "protein_names_refseq": "BTB/POZ domain-containing protein KCTD5; potassium channel tetramerisation domain containing 5", "tax_id": 9913, "disease": "", "pathway": " (bta:100125308)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex (By similarity). Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0097602 cullin family protein binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PKG7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLY7-1", "uniprot_id": [ { "id": "PBIP1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLY7", "type": "external" } ], "mass": 80258.0, "length": 727, "protein_name": "Pre-B-cell leukemia transcription factor-interacting protein 1", "gene_name": "PBXIP1", "organism": "Bovine", "refseq_name": "pre-B-cell leukemia transcription factor-interacting protein 1", "refseq_ac": [ { "id": "NP_001068733", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001068733", "type": "external" } ], "gene_names_uniprotkb": "PBXIP1; HPIP", "gene_names_refseq": "PBXIP1", "protein_names_uniprotkb": "Pre-B-cell leukemia transcription factor-interacting protein 1; Hematopoietic PBX-interacting protein", "protein_names_refseq": "hematopoietic PBX-interacting protein; pre-B-cell leukemia transcription factor-interacting protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:506485)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8Q4", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity;GO:0003713 transcription coactivator activity;GO:0003714 transcription corepressor activity;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005874 microtubule;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0030097 hemopoiesis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QLY7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PKF5-1", "uniprot_id": [ { "id": "THA11_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PKF5", "type": "external" } ], "mass": 33056.0, "length": 303, "protein_name": "THAP domain-containing protein 11", "gene_name": "THAP11", "organism": "Bovine", "refseq_name": "THAP domain-containing protein 11", "refseq_ac": [ { "id": "NP_001098464", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098464", "type": "external" } ], "gene_names_uniprotkb": "THAP11", "gene_names_refseq": "THAP11", "protein_names_uniprotkb": "THAP domain-containing protein 11", "protein_names_refseq": "THAP domain-containing protein 11", "tax_id": 9913, "disease": "", "pathway": " (bta:539845)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor, which has both transcriptional activation and repression activities (By similarity). Also modulates chromatin accessibility (By similarity). In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (By similarity). May regulate the expression of genes that encode both cytoplasmic and mitochondrial ribosomal proteins (By similarity). Required for normal mitochondrial development and function. Regulates mitochondrial gene expression, including that of components of the electron transport chain (By similarity). Involved in the maintainance of pluripotency in early embryonic cells, possibly through its action on mitochondrial maturation which is required to meet high energy demands of these cells (By similarity). Required for early development of retina, preventing premature exit of retinal progenitor cells from the cell cycle. This effect may also be mediated by its action on mitochondria (By similarity). Through the regulation of MMACHC gene expression, controls cobalamin metabolism (By similarity). Required for normal brain development and neural precursor differentiation (By similarity). Involved in cell growth (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PKF5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFH5-1", "uniprot_id": [ { "id": "ALAT1_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFH5", "type": "external" } ], "mass": 55275.0, "length": 496, "protein_name": "Alanine aminotransferase 1", "gene_name": "GPT", "organism": "Bovine", "refseq_name": "alanine aminotransferase 1", "refseq_ac": [ { "id": "NP_001077209", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077209", "type": "external" } ], "gene_names_uniprotkb": "GPT; GPT1", "gene_names_refseq": "GPT", "protein_names_uniprotkb": "Alanine aminotransferase 1; 2.6.1.2; ALT1; GPT 1; Glutamate pyruvate transaminase 1; Glutamic--alanine transaminase 1; Glutamic--pyruvic transaminase 1", "protein_names_refseq": "ALT1; GPT 1; alanine aminotransferase 1; glutamate pyruvate transaminase 1; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:539188); (R-BTA-70268); (R-BTA-8964540)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "26440349", "class_list": "", "function": "Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This study concludes that hepatic expression of alanine transaminase and glutathione synthetase (GS) are reduced in aged cows, and administration of 17beta-estradiol increases plasma estradiol and hepatic GS., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.6.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.6.1.2", "type": "external" } ], "go_molecular_function": "GO:0030170 pyridoxal phosphate binding;GO:0004021 L-alanine:2-oxoglutarate aminotransferase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0042853 L-alanine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4IFH5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H6W9-1", "uniprot_id": [ { "id": "SDS3_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H6W9", "type": "external" } ], "mass": 38133.0, "length": 328, "protein_name": "Sin3 histone deacetylase corepressor complex component SDS3", "gene_name": "SUDS3", "organism": "Bovine", "refseq_name": "sin3 histone deacetylase corepressor complex component SDS3", "refseq_ac": [ { "id": "NP_001092361", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092361", "type": "external" } ], "gene_names_uniprotkb": "SUDS3; SDS3", "gene_names_refseq": "SUDS3", "protein_names_uniprotkb": "Sin3 histone deacetylase corepressor complex component SDS3; Suppressor of defective silencing 3 protein homolog", "protein_names_refseq": "sin3 histone deacetylase corepressor complex component SDS3; suppressor of defective silencing 3 homolog; suppressor of defective silencing 3 protein homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:506646)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0004407 histone deacetylase activity;GO:0019899 enzyme binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body;GO:0070822 Sin3-type complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H6W9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YWN2-1", "uniprot_id": [ { "id": "FITM1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YWN2", "type": "external" } ], "mass": 32253.0, "length": 292, "protein_name": "Fat storage-inducing transmembrane protein 1", "gene_name": "FITM1", "organism": "Bovine", "refseq_name": "fat storage-inducing transmembrane protein 1", "refseq_ac": [ { "id": "NP_001098821", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098821", "type": "external" } ], "gene_names_uniprotkb": "FITM1; FIT1", "gene_names_refseq": "FIT1; FITM1", "protein_names_uniprotkb": "Fat storage-inducing transmembrane protein 1; Fat-inducing protein 1", "protein_names_refseq": "fat storage-inducing transmembrane protein 1; fat-inducing protein 1; fat-inducing transcript 1", "tax_id": 9913, "disease": "", "pathway": " (bta:510040); (R-BTA-8964572)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an important role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis (By similarity). Directly binds to diacylglycerol (DAGs) and triacylglycerol (By similarity)., [UniProtKB, HAMAP]; Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017129 triglyceride binding;GO:0019992 diacylglycerol binding;GO:0010945 coenzyme A diphosphatase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0045444 fat cell differentiation;GO:0019915 lipid storage;GO:0034389 lipid droplet organization;GO:0008654 phospholipid biosynthetic process;GO:0140042 lipid droplet formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YWN2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQ94-1", "uniprot_id": [ { "id": "DMTA2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQ94", "type": "external" } ], "mass": 52989.0, "length": 535, "protein_name": "Doublesex- and mab-3-related transcription factor A2", "gene_name": "DMRTA2", "organism": "Bovine", "refseq_name": "doublesex- and mab-3-related transcription factor A2", "refseq_ac": [ { "id": "NP_001096751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096751", "type": "external" } ], "gene_names_uniprotkb": "DMRTA2; DMRT5", "gene_names_refseq": "DMRTA2", "protein_names_uniprotkb": "Doublesex- and mab-3-related transcription factor A2; Doublesex- and mab-3-related transcription factor 5", "protein_names_refseq": "doublesex- and mab-3-related transcription factor 5; doublesex- and mab-3-related transcription factor A2", "tax_id": 9913, "disease": "", "pathway": " (bta:537680)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in sexual development., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0042802 identical protein binding;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0008344 adult locomotory behavior;GO:0007548 sex differentiation;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQ94-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PKA5-1", "uniprot_id": [ { "id": "SNX27_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PKA5", "type": "external" } ], "mass": 61127.0, "length": 541, "protein_name": "Sorting nexin-27", "gene_name": "SNX27", "organism": "Bovine", "refseq_name": "sorting nexin-27", "refseq_ac": [ { "id": "NP_001092426", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092426", "type": "external" } ], "gene_names_uniprotkb": "SNX27", "gene_names_refseq": "SNX27", "protein_names_uniprotkb": "Sorting nexin-27", "protein_names_refseq": "sorting nexin family member 27; sorting nexin-27", "tax_id": 9913, "disease": "", "pathway": " (bta:513214)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30573663", "class_list": "", "function": "Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005769 early endosome;GO:0005829 cytosol;GO:0031901 early endosome membrane;GO:0001772 immunological synapse;GO:0098978 glutamatergic synapse", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0007165 signal transduction;GO:0016197 endosomal transport;GO:0032456 endocytic recycling;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PKA5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H7E2-1", "uniprot_id": [ { "id": "CINP_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H7E2", "type": "external" } ], "mass": 24128.0, "length": 212, "protein_name": "Cyclin-dependent kinase 2-interacting protein", "gene_name": "CINP", "organism": "Bovine", "refseq_name": "cyclin-dependent kinase 2-interacting protein", "refseq_ac": [ { "id": "NP_001092595", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092595", "type": "external" } ], "gene_names_uniprotkb": "CINP", "gene_names_refseq": "CINP", "protein_names_uniprotkb": "Cyclin-dependent kinase 2-interacting protein", "protein_names_refseq": "cyclin-dependent kinase 2-interacting protein", "tax_id": 9913, "disease": "", "pathway": " (bta:613767)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the DNA replication complex, which interacts with two kinases, CDK2 and CDC7, thereby providing a functional and physical link between CDK2 and CDC7 during firing of the origins of replication. Regulates ATR-mediated checkpoint signaling in response to DNA damage. Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. As part of 55LCC complex, also involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990275 preribosome binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006281 DNA repair;GO:0051301 cell division;GO:0042273 ribosomal large subunit biogenesis;GO:0006260 DNA replication;GO:0090069 regulation of ribosome biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H7E2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QM03-1", "uniprot_id": [ { "id": "FUCT1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QM03", "type": "external" } ], "mass": 40005.0, "length": 364, "protein_name": "GDP-fucose transporter 1", "gene_name": "SLC35C1", "organism": "Bovine", "refseq_name": "GDP-fucose transporter 1", "refseq_ac": [ { "id": "NP_001094680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094680", "type": "external" } ], "gene_names_uniprotkb": "SLC35C1; FUCT1", "gene_names_refseq": "FUCT1; SLC35C1", "protein_names_uniprotkb": "GDP-fucose transporter 1; Solute carrier family 35 member C1", "protein_names_refseq": "GDP-fucose transporter 1", "tax_id": 9913, "disease": "", "pathway": " (bta:540413); (R-BTA-6787639); (R-BTA-727802)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Antiporter specific for GDP-l-fucose and depending on the concomitant reverse transport of GMP. Involved in GDP-fucose import from the cytoplasm into the Golgi lumen., [UniProtKB, UniProtKB]; Putative transporter., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0005457 GDP-fucose transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane", "go_biological_process": "GO:0036085 GDP-fucose import into Golgi lumen;GO:0042351 'de novo' GDP-L-fucose biosynthetic process;GO:0042352 GDP-L-fucose salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QM03-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQ24-1", "uniprot_id": [ { "id": "PIGL_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQ24", "type": "external" } ], "mass": 28330.0, "length": 253, "protein_name": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase", "gene_name": "PIGL", "organism": "Bovine", "refseq_name": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase", "refseq_ac": [ { "id": "NP_001093781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093781", "type": "external" } ], "gene_names_uniprotkb": "PIGL", "gene_names_refseq": "PIGL", "protein_names_uniprotkb": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; 3.5.1.89; PIG-L; Phosphatidylinositol-glycan biosynthesis class L protein", "protein_names_refseq": "N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase; PIG-L; phosphatidylinositol-glycan biosynthesis class L protein", "tax_id": 9913, "disease": "", "pathway": " (bta:507080); (R-BTA-162710)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the second step of glycosylphosphatidylinositol (GPI) biosynthesis, which is the de-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.89", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.89", "type": "external" } ], "go_molecular_function": "GO:0000225 N-acetylglucosaminylphosphatidylinositol deacetylase activity", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQ24-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJR4-1", "uniprot_id": [ { "id": "PURA1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJR4", "type": "external" } ], "mass": 50134.0, "length": 457, "protein_name": "Adenylosuccinate synthetase isozyme 1", "gene_name": "ADSS1", "organism": "Bovine", "refseq_name": "adenylosuccinate synthetase isozyme 1", "refseq_ac": [ { "id": "NP_001092662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092662", "type": "external" } ], "gene_names_uniprotkb": "ADSS1; ADSSL1", "gene_names_refseq": "ADSS1; ADSSL1", "protein_names_uniprotkb": "Adenylosuccinate synthetase isozyme 1; 6.3.4.4; AMPSase 1; AdSS 1; Adenylosuccinate synthetase, basic isozyme; Adenylosuccinate synthetase, muscle isozyme; IMP--aspartate ligase 1; M-type adenylosuccinate synthetase", "protein_names_refseq": "AMPSase 1; IMP--aspartate ligase 1; M-type adenylosuccinate synthetase; adSS 1; adenylosuccinate synthase like 1; adenylosuccinate synthetase isozyme 1; adenylosuccinate synthetase, basic isozyme; adenylosuccinate synthetase, muscle isozyme", "tax_id": 9913, "disease": "", "pathway": " (bta:784089); (R-BTA-73817)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP., [UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP., [UniProtKB, HAMAP]; Plays an important role in the de novo pathway of purine nucleotide biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.3.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.4", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0005525 GTP binding;GO:0004019 adenylosuccinate synthase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0046040 IMP metabolic process;GO:0044208 'de novo' AMP biosynthetic process;GO:0044209 AMP salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJR4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLV3-1", "uniprot_id": [ { "id": "SHOC2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLV3", "type": "external" } ], "mass": 64860.0, "length": 582, "protein_name": "Leucine-rich repeat protein SHOC-2", "gene_name": "SHOC2", "organism": "Bovine", "refseq_name": "leucine-rich repeat protein SHOC-2", "refseq_ac": [ { "id": "NP_001095413", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095413", "type": "external" } ], "gene_names_uniprotkb": "SHOC2", "gene_names_refseq": "SHOC2", "protein_names_uniprotkb": "Leucine-rich repeat protein SHOC-2; Protein soc-2 homolog; Protein sur-8 homolog", "protein_names_refseq": "leucine-rich repeat protein SHOC-2; protein soc-2 homolog; protein sur-8 homolog; soc-2 suppressor of clear homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:511417); (R-BTA-5673000)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway (By similarity). Acts as a scaffolding protein in the SMP complex (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity). Acts as an inhibitor of keratinocyte differentiation via interaction with RAS protein complexes that promote ERK activation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008157 protein phosphatase 1 binding;GO:0019903 protein phosphatase binding", "go_cellular_component": "GO:0000164 protein phosphatase type 1 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0035556 intracellular signal transduction;GO:0043408 regulation of MAPK cascade;GO:0038180 nerve growth factor signaling pathway;GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLV3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B860-1", "uniprot_id": [ { "id": "E1B860_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B860", "type": "external" } ], "mass": 163332.0, "length": 1457, "protein_name": "Intraflagellar transport protein 140 homolog", "gene_name": "IFT140", "organism": "Bovine", "refseq_name": "intraflagellar transport protein 140 homolog isoform X1", "refseq_ac": [ { "id": "XP_002697959", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697959", "type": "external" } ], "gene_names_uniprotkb": "IFT140", "gene_names_refseq": "IFT140", "protein_names_uniprotkb": "Intraflagellar transport protein 140 homolog; WD and tetratricopeptide repeats protein 2", "protein_names_refseq": "intraflagellar transport protein 140 homolog isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:100139697); (R-BTA-5610787); (R-BTA-5620924)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance. Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0005813 centrosome;GO:0005814 centriole;GO:0005930 axoneme;GO:0036064 ciliary basal body", "go_biological_process": "GO:0060271 cilium assembly;GO:0097499 protein localization to non-motile cilium;GO:1902017 regulation of cilium assembly;GO:0035721 intraciliary retrograde transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B860-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B8N2-1", "uniprot_id": [ { "id": "E1B8N2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B8N2", "type": "external" } ], "mass": 31381.0, "length": 275, "protein_name": "Alkaline ceramidase", "gene_name": "ACER2", "organism": "Bovine", "refseq_name": "alkaline ceramidase 2", "refseq_ac": [ { "id": "NP_001179704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179704", "type": "external" } ], "gene_names_uniprotkb": "ACER2", "gene_names_refseq": "ACER2; ASAH3L", "protein_names_uniprotkb": "Alkaline ceramidase; 3.5.1.-", "protein_names_refseq": "alkaline ceramidase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:540732); (R-BTA-9845614)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.5.1.60", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.60", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0017040 N-acylsphingosine amidohydrolase activity", "go_cellular_component": "GO:0016020 membrane;GO:0000139 Golgi membrane", "go_biological_process": "GO:0046512 sphingosine biosynthetic process;GO:0006672 ceramide metabolic process;GO:0008284 positive regulation of cell population proliferation;GO:0010506 regulation of autophagy;GO:0046514 ceramide catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B8N2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQZ7-1", "uniprot_id": [ { "id": "MPP7_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQZ7", "type": "external" } ], "mass": 65534.0, "length": 576, "protein_name": "MAGUK p55 subfamily member 7", "gene_name": "MPP7", "organism": "Bovine", "refseq_name": "MAGUK p55 subfamily member 7", "refseq_ac": [ { "id": "NP_001093817", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093817", "type": "external" } ], "gene_names_uniprotkb": "MPP7", "gene_names_refseq": "MPP7", "protein_names_uniprotkb": "MAGUK p55 subfamily member 7", "protein_names_refseq": "MAGUK p55 subfamily member 7; membrane palmitoylated protein 7; membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)", "tax_id": 9913, "disease": "", "pathway": " (bta:512659); (R-BTA-9013404); (R-BTA-9013406); (R-BTA-9013408); (R-BTA-9013423)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0005923 bicellular tight junction;GO:0005938 cell cortex", "go_biological_process": "GO:0071896 protein localization to adherens junction;GO:0031334 positive regulation of protein-containing complex assembly;GO:0070830 bicellular tight junction assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQZ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBJ5-1", "uniprot_id": [ { "id": "CAND1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MBJ5", "type": "external" } ], "mass": 136376.0, "length": 1230, "protein_name": "Cullin-associated NEDD8-dissociated protein 1", "gene_name": "CAND1", "organism": "Bovine", "refseq_name": "cullin-associated NEDD8-dissociated protein 1", "refseq_ac": [ { "id": "NP_001094643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094643", "type": "external" } ], "gene_names_uniprotkb": "CAND1", "gene_names_refseq": "CAND1", "protein_names_uniprotkb": "Cullin-associated NEDD8-dissociated protein 1; Cullin-associated and neddylation-dissociated protein 1", "protein_names_refseq": "cullin-associated NEDD8-dissociated protein 1; cullin-associated and neddylation-dissociated protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:538086); (R-BTA-6798695); (R-BTA-8951664); (R-BTA-917937)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0031461 cullin-RING ubiquitin ligase complex;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0010265 SCF complex assembly;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBJ5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8E4N3-1", "uniprot_id": [ { "id": "RSPH3_BOVIN", "url": "https://www.uniprot.org/uniprot/A8E4N3", "type": "external" } ], "mass": 68700.0, "length": 606, "protein_name": "Radial spoke head protein 3 homolog", "gene_name": "RSPH3", "organism": "Bovine", "refseq_name": "radial spoke head protein 3 homolog", "refseq_ac": [ { "id": "NP_001103269", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103269", "type": "external" } ], "gene_names_uniprotkb": "RSPH3; RSHL2", "gene_names_refseq": "RSPH3", "protein_names_uniprotkb": "Radial spoke head protein 3 homolog; A-kinase anchor protein RSPH3; Radial spoke head-like protein 2", "protein_names_refseq": "A-kinase anchor protein RSPH3; radial spoke 3 homolog; radial spoke head 3 homolog; radial spoke head protein 3 homolog; radial spoke head-like protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:533135)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (By similarity). Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005929 cilium;GO:0097729 9+2 motile cilium;GO:0001535 radial spoke head", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8E4N3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFM3-1", "uniprot_id": [ { "id": "DR9C7_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFM3", "type": "external" } ], "mass": 35191.0, "length": 313, "protein_name": "Short-chain dehydrogenase/reductase family 9C member 7", "gene_name": "SDR9C7", "organism": "Bovine", "refseq_name": "short-chain dehydrogenase/reductase family 9C member 7", "refseq_ac": [ { "id": "NP_001077206", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077206", "type": "external" } ], "gene_names_uniprotkb": "SDR9C7; RDHS; SDRO", "gene_names_refseq": "SDR-O; SDR9C7", "protein_names_uniprotkb": "Short-chain dehydrogenase/reductase family 9C member 7; 1.1.1.-; O-acylceramide dehydrogenase; Orphan short-chain dehydrogenase/reductase; SDR-O; SDR9C7", "protein_names_refseq": "O-acylceramide dehydrogenase; orphan short-chain dehydrogenase / reductase; orphan short-chain dehydrogenase/reductase; short-chain dehydrogenase/reductase family 9C member 7", "tax_id": 9913, "disease": "", "pathway": " (bta:538876); (R-BTA-2453902)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a crucial role in the formation of the epidermal permeability barrier. Catalyzes the NAD+-dependent dehydrogenation of the linoleate 9,10-trans-epoxy-11E-13-alcohol esterified in omega-O-acylceramides (such as in N-[omega-(9R,10R)-epoxy-(13R)-hydroxy-(11E)-octadecenoyloxy]-acylsphing-4E-enine) to the corresponding 13-ketone, the reactive moiety required for binding of epidermal ceramides to proteins. Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-", "type": "external" }, { "id": "1.1.1.315", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.315", "type": "external" }, { "id": "1.1.1.209", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.209", "type": "external" }, { "id": "1.1.1.53", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53", "type": "external" }, { "id": "1.1.1.105", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.105", "type": "external" } ], "go_molecular_function": "GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0042572 retinol metabolic process;GO:0008202 steroid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFM3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQZ0-1", "uniprot_id": [ { "id": "GDAP1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQZ0", "type": "external" } ], "mass": 41202.0, "length": 358, "protein_name": "Ganglioside-induced differentiation-associated protein 1", "gene_name": "GDAP1", "organism": "Bovine", "refseq_name": "ganglioside-induced differentiation-associated protein 1", "refseq_ac": [ { "id": "NP_001094692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094692", "type": "external" } ], "gene_names_uniprotkb": "GDAP1", "gene_names_refseq": "GDAP1", "protein_names_uniprotkb": "Ganglioside-induced differentiation-associated protein 1; GDAP1", "protein_names_refseq": "ganglioside-induced differentiation-associated protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:613472); (R-BTA-9603798)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Regulates the mitochondrial network by promoting mitochondrial fission., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005741 mitochondrial outer membrane", "go_biological_process": "GO:0006626 protein targeting to mitochondrion;GO:0008053 mitochondrial fusion;GO:0000266 mitochondrial fission", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QQZ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDN0-1", "uniprot_id": [ { "id": "ITM2C_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDN0", "type": "external" } ], "mass": 30673.0, "length": 271, "protein_name": "Integral membrane protein 2C", "gene_name": "ITM2C", "organism": "Bovine", "refseq_name": "integral membrane protein 2C", "refseq_ac": [ { "id": "NP_001075007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075007", "type": "external" } ], "gene_names_uniprotkb": "ITM2C", "gene_names_refseq": "ITM2C; ITM3", "protein_names_uniprotkb": "Integral membrane protein 2C", "protein_names_refseq": "integral membrane protein 2C; integral membrane protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:539959)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0005524 ATP binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0042985 negative regulation of amyloid precursor protein biosynthetic process;GO:0030182 neuron differentiation;GO:0010977 negative regulation of neuron projection development;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDN0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNZ8-1", "uniprot_id": [ { "id": "VOPP1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNZ8", "type": "external" } ], "mass": 19357.0, "length": 172, "protein_name": "WW domain binding protein VOPP1", "gene_name": "VOPP1", "organism": "Bovine", "refseq_name": "WW domain binding protein VOPP1 precursor", "refseq_ac": [ { "id": "NP_001070440", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070440", "type": "external" } ], "gene_names_uniprotkb": "VOPP1; ECOP", "gene_names_refseq": "ECOP; VOPP1", "protein_names_uniprotkb": "WW domain binding protein VOPP1; ECop; EGFR-coamplified and overexpressed protein; Vesicular, overexpressed in cancer, prosurvival protein 1", "protein_names_refseq": "EGFR-coamplified and overexpressed protein; VOPP1, WBP1/VOPP1 family member; WW domain binding protein VOPP1 precursor; WW domain binding protein VOPP1; vesicular, overexpressed in cancer, prosurvival protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:767861)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed. May sequester WWOX in lysosomal vesicles and thereby regulate WWOX role as tumor suppressor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q58D61", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005765 lysosomal membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031902 late endosome membrane;GO:0031090 organelle membrane", "go_biological_process": "GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QNZ8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H7B0-1", "uniprot_id": [ { "id": "PLLP_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H7B0", "type": "external" } ], "mass": 19778.0, "length": 182, "protein_name": "Plasmolipin", "gene_name": "PLLP", "organism": "Bovine", "refseq_name": "plasmolipin", "refseq_ac": [ { "id": "NP_001092593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092593", "type": "external" } ], "gene_names_uniprotkb": "PLLP", "gene_names_refseq": "PLLP", "protein_names_uniprotkb": "Plasmolipin; Plasma membrane proteolipid", "protein_names_refseq": "plasma membrane proteolipid (plasmolipin); plasmolipin", "tax_id": 9913, "disease": "", "pathway": " (bta:613446)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "1695242", "class_list": "", "function": "Main component of the myelin sheath that plays an important role in myelin membrane biogenesis and myelination (By similarity). Plays an essential function in apical endocytosis. Regulates epithelial development through the regulation of apical endocytosis (By similarity). Part of the intracellular machinery that mediates basolateral-to-apical transport of ICAM-1, an essential adhesion receptor in epithelial cells, from the subapical compartment in hepatic epithelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath;GO:0042802 identical protein binding", "go_cellular_component": "GO:0016020 membrane;GO:0043209 myelin sheath;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030100 regulation of endocytosis;GO:0042552 myelination;GO:0032288 myelin assembly;GO:1904298 regulation of transcytosis", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6H7B0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV84-1", "uniprot_id": [ { "id": "MRT4_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV84", "type": "external" } ], "mass": 27526.0, "length": 239, "protein_name": "mRNA turnover protein 4 homolog", "gene_name": "MRTO4", "organism": "Bovine", "refseq_name": "mRNA turnover protein 4 homolog", "refseq_ac": [ { "id": "NP_001076868", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076868", "type": "external" } ], "gene_names_uniprotkb": "MRTO4", "gene_names_refseq": "MRTO4", "protein_names_uniprotkb": "mRNA turnover protein 4 homolog; Ribosome assembly factor MRTO4", "protein_names_refseq": "mRNA turnover 4 homolog; mRNA turnover protein 4 homolog; ribosome assembly factor MRTO4", "tax_id": 9913, "disease": "", "pathway": " (bta:509932)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030687 preribosome, large subunit precursor", "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:0000956 nuclear-transcribed mRNA catabolic process;GO:0006364 rRNA processing;GO:0000027 ribosomal large subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV84-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B793-1", "uniprot_id": [ { "id": "E1B793_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B793", "type": "external" } ], "mass": 146246.0, "length": 1335, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "STK36", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "STK36", "gene_names_refseq": "", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1; Fused homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0001222 transcription corepressor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0009791 post-embryonic development;GO:0007224 smoothened signaling pathway;GO:0035082 axoneme assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B793-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7F4-1", "uniprot_id": [ { "id": "E1B7F4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7F4", "type": "external" } ], "mass": 34962.0, "length": 316, "protein_name": "C-type lectin domain family 4 member G", "gene_name": "CLEC4G", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CLEC4G", "gene_names_refseq": "", "protein_names_uniprotkb": "C-type lectin domain family 4 member G", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-198933)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding;GO:0030247 polysaccharide binding;GO:0001618 virus receptor activity;GO:0070061 fructose binding;GO:0005537 D-mannose binding", "go_cellular_component": "GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:1903902 positive regulation of viral life cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7F4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H7H7-1", "uniprot_id": [ { "id": "FBX3_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H7H7", "type": "external" } ], "mass": 54129.0, "length": 469, "protein_name": "F-box only protein 3", "gene_name": "FBXO3", "organism": "Bovine", "refseq_name": "F-box only protein 3", "refseq_ac": [ { "id": "NP_001092532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092532", "type": "external" } ], "gene_names_uniprotkb": "FBXO3; FBX3", "gene_names_refseq": "FBXO3", "protein_names_uniprotkb": "F-box only protein 3", "protein_names_refseq": "F-box only protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:534287)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS) (By similarity). The SCF(FBXO3) complex specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0016567 protein ubiquitination;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H7H7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNT8-1", "uniprot_id": [ { "id": "SC24A_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNT8", "type": "external" } ], "mass": 120097.0, "length": 1099, "protein_name": "Protein transport protein Sec24A", "gene_name": "SEC24A", "organism": "Bovine", "refseq_name": "protein transport protein Sec24A", "refseq_ac": [ { "id": "NP_001095319", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095319", "type": "external" } ], "gene_names_uniprotkb": "SEC24A", "gene_names_refseq": "SEC24A", "protein_names_uniprotkb": "Protein transport protein Sec24A; SEC24-related protein A", "protein_names_refseq": "SEC24 family, member A; SEC24 related gene family, member A; SEC24-related protein A; protein transport protein Sec24A", "tax_id": 9913, "disease": "", "pathway": " (bta:505089); (R-BTA-204005); (R-BTA-2132295); (R-BTA-5694530); (R-BTA-983170)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QNT8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBC7-1", "uniprot_id": [ { "id": "NEMP1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MBC7", "type": "external" } ], "mass": 50958.0, "length": 445, "protein_name": "Nuclear envelope integral membrane protein 1", "gene_name": "NEMP1", "organism": "Bovine", "refseq_name": "nuclear envelope integral membrane protein 1 precursor", "refseq_ac": [ { "id": "NP_001095631", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095631", "type": "external" } ], "gene_names_uniprotkb": "NEMP1; TMEM194A", "gene_names_refseq": "NEMP1; TMEM194A; TMEM194", "protein_names_uniprotkb": "Nuclear envelope integral membrane protein 1", "protein_names_refseq": "nuclear envelope integral membrane protein 1 precursor; transmembrane protein 194A; transmembrane protein 194", "tax_id": 9913, "disease": "", "pathway": " (bta:533988)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Together with EMD, contributes to nuclear envelope stiffness in germ cells (By similarity). Required for female fertility (By similarity). Essential for normal erythropoiesis (By similarity). Required for efficient nuclear envelope opening and enucleation during the late stages of erythroblast maturation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005637 nuclear inner membrane", "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0071763 nuclear membrane organization;GO:0043131 erythrocyte enucleation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBC7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0N0X6-1", "uniprot_id": [ { "id": "LRRN1_BOVIN", "url": "https://www.uniprot.org/uniprot/A0N0X6", "type": "external" } ], "mass": 80831.0, "length": 716, "protein_name": "Leucine-rich repeat neuronal protein 1", "gene_name": "LRRN1", "organism": "Bovine", "refseq_name": "leucine-rich repeat neuronal protein 1 precursor", "refseq_ac": [ { "id": "NP_001074207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074207", "type": "external" } ], "gene_names_uniprotkb": "LRRN1", "gene_names_refseq": "LRRN1; NLRR-1", "protein_names_uniprotkb": "Leucine-rich repeat neuronal protein 1; NLRR-1; Neuronal leucine-rich repeat protein 1", "protein_names_refseq": "leucine-rich repeat neuronal protein 1 precursor; leucine-rich repeat neuronal protein 1; leucine-rich repeats and calponin homology (CH) domain containing 4; neuronal leucine-rich repeat protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:539619)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 8, "predicted_n_glycosites": 8, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0N0X6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MAZ4-1", "uniprot_id": [ { "id": "TAF8_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MAZ4", "type": "external" } ], "mass": 34227.0, "length": 310, "protein_name": "Transcription initiation factor TFIID subunit 8", "gene_name": "TAF8", "organism": "Bovine", "refseq_name": "transcription initiation factor TFIID subunit 8", "refseq_ac": [ { "id": "NP_001094670", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094670", "type": "external" } ], "gene_names_uniprotkb": "TAF8", "gene_names_refseq": "TAF8", "protein_names_uniprotkb": "Transcription initiation factor TFIID subunit 8; TBP-associated factor 8", "protein_names_refseq": "TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa; TBP-associated factor 8; transcription initiation factor TFIID subunit 8", "tax_id": 9913, "disease": "", "pathway": " (bta:539938); (R-BTA-674695); (R-BTA-6804756); (R-BTA-6807505); (R-BTA-73776); (R-BTA-73779); (R-BTA-75953); (R-BTA-76042)", "pathway_count": 8, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. The TFIID complex structure can be divided into 3 modules TFIID-A, TFIID-B, and TFIID-C. TAF8 is involved in forming the TFIID-B module, together with TAF5. Mediates both basal and activator-dependent transcription. Plays a role in the differentiation of preadipocyte fibroblasts to adipocytes, however, does not seem to play a role in differentiation of myoblasts. Required for the integration of TAF10 in the TAF complex (By similarity). May be important for survival of cells of the inner cell mass which constitute the pluripotent cell population of the early embryo (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046982 protein heterodimerization activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005669 transcription factor TFIID complex;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0030154 cell differentiation;GO:0006367 transcription initiation at RNA polymerase II promoter;GO:0006351 DNA-templated transcription;GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0042789 mRNA transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MAZ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YY28-1", "uniprot_id": [ { "id": "ABHEB_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YY28", "type": "external" } ], "mass": 22455.0, "length": 210, "protein_name": "Putative protein-lysine deacylase ABHD14B", "gene_name": "ABHD14B", "organism": "Bovine", "refseq_name": "putative protein-lysine deacylase ABHD14B", "refseq_ac": [ { "id": "NP_001098911", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098911", "type": "external" } ], "gene_names_uniprotkb": "ABHD14B", "gene_names_refseq": "ABHD14B", "protein_names_uniprotkb": "Putative protein-lysine deacylase ABHD14B; 2.3.1.-; Abhydrolase domain-containing protein 14B; Alpha/beta hydrolase domain-containing protein 14B", "protein_names_refseq": "Abhydrolase domain-containing protein 14B; alpha/beta hydrolase domain-containing protein 14B; protein ABHD14B; putative protein-lysine deacylase ABHD14B", "tax_id": 9913, "disease": "", "pathway": " (bta:615289); (R-BTA-156584)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as an atypical protein-lysine deacetylase in vitro. Catalyzes the deacetylation of lysine residues using CoA as substrate, generating acetyl-CoA and the free amine of protein-lysine residues. Additional experiments are however required to confirm the protein-lysine deacetylase activity in vivo. Has hydrolase activity towards various surrogate p-nitrophenyl (pNp) substrates, such as pNp-butyrate, pNp-acetate and pNp-octanoate in vitro, with a strong preference for pNp-acetate. May activate transcription., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.3.1.259", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.259", "type": "external" } ], "go_molecular_function": "GO:0061733 protein-lysine-acetyltransferase activity;GO:0016787 hydrolase activity;GO:0016746 acyltransferase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005634 nucleus", "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YY28-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLU8-1", "uniprot_id": [ { "id": "NXN_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLU8", "type": "external" } ], "mass": 48331.0, "length": 435, "protein_name": "Nucleoredoxin", "gene_name": "NXN", "organism": "Bovine", "refseq_name": "nucleoredoxin", "refseq_ac": [ { "id": "NP_001095606", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095606", "type": "external" } ], "gene_names_uniprotkb": "NXN", "gene_names_refseq": "NXN", "protein_names_uniprotkb": "Nucleoredoxin; 1.8.1.8", "protein_names_refseq": "nucleoredoxin", "tax_id": 9913, "disease": "", "pathway": " (bta:531367)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.8", "type": "external" } ], "go_molecular_function": "GO:0004791 thioredoxin-disulfide reductase (NADPH) activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0072359 circulatory system development;GO:0030154 cell differentiation;GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway;GO:0031397 negative regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLU8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUG8-1", "uniprot_id": [ { "id": "RABE2_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUG8", "type": "external" } ], "mass": 65602.0, "length": 585, "protein_name": "Rab GTPase-binding effector protein 2", "gene_name": "RABEP2", "organism": "Bovine", "refseq_name": "rab GTPase-binding effector protein 2", "refseq_ac": [ { "id": "NP_001076877", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076877", "type": "external" } ], "gene_names_uniprotkb": "RABEP2", "gene_names_refseq": "RABEP2", "protein_names_uniprotkb": "Rab GTPase-binding effector protein 2", "protein_names_refseq": "rab GTPase-binding effector protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:511736)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in membrane trafficking and in homotypic early endosome fusion. Participates in arteriogenesis by regulating vascular endothelial growth factor receptor 2/VEGFR2 cell surface expression and endosomal trafficking. By interacting with SDCCAG8, localizes to centrosomes and plays a critical role in ciliogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005813 centrosome;GO:0005829 cytosol;GO:0036064 ciliary basal body", "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0030030 cell projection organization;GO:1902017 regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUG8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7C1-1", "uniprot_id": [ { "id": "DDX52_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7C1", "type": "external" } ], "mass": 67509.0, "length": 596, "protein_name": "Probable ATP-dependent RNA helicase DDX52", "gene_name": "DDX52", "organism": "Bovine", "refseq_name": "probable ATP-dependent RNA helicase DDX52", "refseq_ac": [ { "id": "NP_001096708", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096708", "type": "external" } ], "gene_names_uniprotkb": "DDX52", "gene_names_refseq": "DDX52", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX52; 3.6.4.13; DEAD box protein 52", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 52; DEAD box protein 52; DEAD-box helicase 52; probable ATP-dependent RNA helicase DDX52", "tax_id": 9913, "disease": "", "pathway": " (bta:510826); (R-BTA-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7C1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D962-1", "uniprot_id": [ { "id": "PHF23_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D962", "type": "external" } ], "mass": 43440.0, "length": 400, "protein_name": "PHD finger protein 23", "gene_name": "PHF23", "organism": "Bovine", "refseq_name": "PHD finger protein 23", "refseq_ac": [ { "id": "NP_001019741", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019741", "type": "external" } ], "gene_names_uniprotkb": "PHF23", "gene_names_refseq": "PHF23", "protein_names_uniprotkb": "PHD finger protein 23; PDH-containing protein JUNE-1", "protein_names_refseq": "PDH-containing protein JUNE-1; PHD finger protein 23", "tax_id": 9913, "disease": "", "pathway": " (bta:539774)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "Q58CU8", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:1901097 negative regulation of autophagosome maturation;GO:1902902 negative regulation of autophagosome assembly;GO:0006914 autophagy;GO:0031398 positive regulation of protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5D962-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV45-1", "uniprot_id": [ { "id": "TM214_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV45", "type": "external" } ], "mass": 77016.0, "length": 687, "protein_name": "Transmembrane protein 214", "gene_name": "TMEM214", "organism": "Bovine", "refseq_name": "transmembrane protein 214", "refseq_ac": [ { "id": "NP_001076901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076901", "type": "external" } ], "gene_names_uniprotkb": "TMEM214", "gene_names_refseq": "TMEM214", "protein_names_uniprotkb": "Transmembrane protein 214", "protein_names_refseq": "transmembrane protein 214", "tax_id": 9913, "disease": "", "pathway": " (bta:514683)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Critical mediator, in cooperation with CASP4, of endoplasmic reticulum-stress induced apoptosis. Required or the activation of CASP4 following endoplasmic reticulum stress., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0005881 cytoplasmic microtubule", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV45-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H754-1", "uniprot_id": [ { "id": "CD37L_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H754", "type": "external" } ], "mass": 38850.0, "length": 337, "protein_name": "Hsp90 co-chaperone Cdc37-like 1", "gene_name": "CDC37L1", "organism": "Bovine", "refseq_name": "hsp90 co-chaperone Cdc37-like 1", "refseq_ac": [ { "id": "NP_001092401", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092401", "type": "external" } ], "gene_names_uniprotkb": "CDC37L1", "gene_names_refseq": "CDC37L1", "protein_names_uniprotkb": "Hsp90 co-chaperone Cdc37-like 1", "protein_names_refseq": "cell division cycle 37 homolog-like 1; cell division cycle 37 like 1; hsp90 co-chaperone Cdc37-like 1", "tax_id": 9913, "disease": "", "pathway": " (bta:510572); (R-BTA-114608)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Co-chaperone that binds to numerous proteins and promotes their interaction with Hsp70 and Hsp90., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0051087 protein-folding chaperone binding;GO:0031072 heat shock protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0050821 protein stabilization;GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H754-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B731-1", "uniprot_id": [ { "id": "E1B731_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B731", "type": "external" } ], "mass": 34684.0, "length": 324, "protein_name": "GDT1 family protein", "gene_name": "TMEM165", "organism": "Bovine", "refseq_name": "putative divalent cation/proton antiporter TMEM165 precursor", "refseq_ac": [ { "id": "NP_001192935", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192935", "type": "external" } ], "gene_names_uniprotkb": "TMEM165", "gene_names_refseq": "TMEM165", "protein_names_uniprotkb": "GDT1 family protein", "protein_names_refseq": "putative divalent cation/proton antiporter TMEM165 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:532600)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046873 metal ion transmembrane transporter activity;GO:0015085 calcium ion transmembrane transporter activity;GO:0005384 manganese ion transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005794 Golgi apparatus;GO:0032588 trans-Golgi network membrane;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0070588 calcium ion transmembrane transport;GO:0032468 Golgi calcium ion homeostasis;GO:0032472 Golgi calcium ion transport;GO:0071421 manganese ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B731-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQX9-1", "uniprot_id": [ { "id": "TM163_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQX9", "type": "external" } ], "mass": 31195.0, "length": 287, "protein_name": "Transmembrane protein 163", "gene_name": "TMEM163", "organism": "Bovine", "refseq_name": "transmembrane protein 163", "refseq_ac": [ { "id": "NP_001094630", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094630", "type": "external" } ], "gene_names_uniprotkb": "TMEM163", "gene_names_refseq": "TMEM163", "protein_names_uniprotkb": "Transmembrane protein 163", "protein_names_refseq": "transmembrane protein 163", "tax_id": 9913, "disease": "", "pathway": " (bta:534678)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (By similarity). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (By similarity). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0030672 synaptic vesicle membrane", "go_biological_process": "GO:0042552 myelination;GO:0006882 intracellular zinc ion homeostasis;GO:0140882 zinc export across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QQX9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUC0-1", "uniprot_id": [ { "id": "RM37_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUC0", "type": "external" } ], "mass": 48053.0, "length": 423, "protein_name": "Large ribosomal subunit protein mL37", "gene_name": "MRPL37", "organism": "Bovine", "refseq_name": "large ribosomal subunit protein mL37", "refseq_ac": [ { "id": "NP_001076869", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076869", "type": "external" } ], "gene_names_uniprotkb": "MRPL37", "gene_names_refseq": "L37mt; MRP-L37; MRPL37", "protein_names_uniprotkb": "Large ribosomal subunit protein mL37; 39S ribosomal protein L37, mitochondrial; L37mt; MRP-L37", "protein_names_refseq": "39S ribosomal protein L37, mitochondrial; large ribosomal subunit protein mL37", "tax_id": 9913, "disease": "", "pathway": " (bta:510127); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "10600119", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0005762 mitochondrial large ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006412 translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4FUC0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQD2-1", "uniprot_id": [ { "id": "ACTMP_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQD2", "type": "external" } ], "mass": 37437.0, "length": 348, "protein_name": "Actin maturation protease", "gene_name": "ACTMAP", "organism": "Bovine", "refseq_name": "actin maturation protease", "refseq_ac": [ { "id": "NP_001157497", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157497", "type": "external" } ], "gene_names_uniprotkb": "ACTMAP", "gene_names_refseq": "ACTMAP; C18H19orf54", "protein_names_uniprotkb": "Actin maturation protease; 3.4.11.-; Actin aminopeptidase ACTMAP", "protein_names_refseq": "UPF0692 protein C19orf54 homolog; actin aminopeptidase ACTMAP; actin maturation protease; chromosome 18 C19orf54 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:509803)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (By similarity). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins ACTB and ACTG1 after translation (By similarity). Cleaves N-terminal acetylated cysteine of muscle alpha-actins ACTA1, ACTC1 and ACTA2 after canonical removal of N-terminal methionine (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-", "type": "external" } ], "go_molecular_function": "GO:0004239 initiator methionyl aminopeptidase activity;GO:0070005 cysteine-type aminopeptidase activity;GO:0004177 aminopeptidase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0016485 protein processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQD2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B782-1", "uniprot_id": [ { "id": "E1B782_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B782", "type": "external" } ], "mass": 527046.0, "length": 4837, "protein_name": "E3 ubiquitin-protein ligase HERC2", "gene_name": "HERC2", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase HERC2", "refseq_ac": [ { "id": "NP_001193010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193010", "type": "external" } ], "gene_names_uniprotkb": "HERC2", "gene_names_refseq": "HERC2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HERC2; 2.3.2.26; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2", "protein_names_refseq": "E3 ubiquitin-protein ligase HERC2; hect domain and RLD 2", "tax_id": 9913, "disease": "", "pathway": " (bta:535440); (R-BTA-3108214); (R-BTA-5693565); (R-BTA-5693571); (R-BTA-5693607); (R-BTA-69473); (R-BTA-983168)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Also modulates iron metabolism by regulating the basal turnover of FBXL5., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005814 centriole;GO:0005737 cytoplasm;GO:0016020 membrane", "go_biological_process": "GO:0006281 DNA repair;GO:0016567 protein ubiquitination;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B782-1", "record_type": "protein", "filter_code": "0000000.0000001.000100.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLK6-1", "uniprot_id": [ { "id": "GRAP_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLK6", "type": "external" } ], "mass": 25367.0, "length": 217, "protein_name": "GRB2-related adapter protein", "gene_name": "GRAP", "organism": "Bovine", "refseq_name": "GRB2-related adapter protein", "refseq_ac": [ { "id": "NP_001095643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095643", "type": "external" } ], "gene_names_uniprotkb": "GRAP", "gene_names_refseq": "GRAP", "protein_names_uniprotkb": "GRB2-related adapter protein", "protein_names_refseq": "GRB2-related adapter protein", "tax_id": 9913, "disease": "", "pathway": " (bta:534491); (R-BTA-1433557)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Couples signals from receptor and cytoplasmic tyrosine kinases to the Ras signaling pathway. Plays a role in the inner ear and in hearing., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0005154 epidermal growth factor receptor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0098793 presynapse;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0007165 signal transduction;GO:0007265 Ras protein signal transduction;GO:0007605 sensory perception of sound;GO:0043408 regulation of MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLK6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B887-1", "uniprot_id": [ { "id": "E1B887_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B887", "type": "external" } ], "mass": 65189.0, "length": 568, "protein_name": "Serine/threonine-protein kinase RIO1", "gene_name": "RIOK1", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase RIO1 isoform X1", "refseq_ac": [ { "id": "XP_002697645", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002697645", "type": "external" } ], "gene_names_uniprotkb": "RIOK1", "gene_names_refseq": "RIOK1", "protein_names_uniprotkb": "Serine/threonine-protein kinase RIO1; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase RIO1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:516289); (R-BTA-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor. The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. The catalytic activity regulates its dynamic association with the 40S subunit. In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030688 preribosome, small subunit precursor;GO:0034708 methyltransferase complex", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:2000234 positive regulation of rRNA processing;GO:0030490 maturation of SSU-rRNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B887-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9QWP9-1", "uniprot_id": [ { "id": "CXCL9_BOVIN", "url": "https://www.uniprot.org/uniprot/A9QWP9", "type": "external" } ], "mass": 14106.0, "length": 125, "protein_name": "C-X-C motif chemokine 9", "gene_name": "CXCL9", "organism": "Bovine", "refseq_name": "C-X-C motif chemokine 9 precursor", "refseq_ac": [ { "id": "NP_001106643", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106643", "type": "external" } ], "gene_names_uniprotkb": "CXCL9", "gene_names_refseq": "CXCL9", "protein_names_uniprotkb": "C-X-C motif chemokine 9; Small-inducible cytokine B9", "protein_names_refseq": "C-X-C motif chemokine 9 precursor; C-X-C motif chemokine 9; monokine induced by interferon gamma; small-inducible cytokine B9", "tax_id": 9913, "disease": "", "pathway": " (bta:513990); (R-BTA-380108); (R-BTA-418594)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "21497916;22909117", "class_list": "", "function": "CXCK9 and CXCL10 chemokines displayed a trend of decreasing mRNA expression as lesion progressed, suggesting a higher level of importance during the early stages of the immune response to mycobacterial infection., [RefSeq, PubMed]; Cytokine that affects the growth, movement, or activation state of cells that participate in immune and inflammatory response. Chemotactic for activated T-cells. Binds to CXCR3 (By similarity)., [UniProtKB]; This report describes the cloning and characterization of expressed gene sequences of bovine, equine, and swine CXCL9 from RNA obtained from peripheral blood mononuclear cells and other tissues., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008009 chemokine activity;GO:0045236 CXCR chemokine receptor binding;GO:0048248 CXCR3 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A9QWP9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQ77-1", "uniprot_id": [ { "id": "SACA3_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQ77", "type": "external" } ], "mass": 18099.0, "length": 163, "protein_name": "Sperm acrosome membrane-associated protein 3", "gene_name": "SPACA3", "organism": "Bovine", "refseq_name": "sperm acrosome membrane-associated protein 3 precursor", "refseq_ac": [ { "id": "NP_001098477", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098477", "type": "external" } ], "gene_names_uniprotkb": "SPACA3", "gene_names_refseq": "SPACA3", "protein_names_uniprotkb": "Sperm acrosome membrane-associated protein 3", "protein_names_refseq": "sperm acrosome membrane-associated protein 3 precursor; sperm acrosome membrane-associated protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:617955)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003796 lysozyme activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum", "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQ77-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPE1-1", "uniprot_id": [ { "id": "RBM48_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPE1", "type": "external" } ], "mass": 41206.0, "length": 362, "protein_name": "RNA-binding protein 48", "gene_name": "RBM48", "organism": "Bovine", "refseq_name": "RNA-binding protein 48", "refseq_ac": [ { "id": "NP_001095324", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095324", "type": "external" } ], "gene_names_uniprotkb": "RBM48", "gene_names_refseq": "C4H7orf64; RBM48", "protein_names_uniprotkb": "RNA-binding protein 48", "protein_names_refseq": "RNA-binding protein 48; UPF0712 protein C7orf64 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:505408)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "11282978", "class_list": "", "function": "As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QPE1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7E3Q8-1", "uniprot_id": [ { "id": "PLST_BOVIN", "url": "https://www.uniprot.org/uniprot/A7E3Q8", "type": "external" } ], "mass": 70798.0, "length": 630, "protein_name": "Plastin-3", "gene_name": "PLS3", "organism": "Bovine", "refseq_name": "plastin-3 isoform X1", "refseq_ac": [ { "id": "XP_005227971", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005227971", "type": "external" } ], "gene_names_uniprotkb": "PLS3", "gene_names_refseq": "PLS3", "protein_names_uniprotkb": "Plastin-3; T-plastin", "protein_names_refseq": "plastin-3 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Actin-bundling protein., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051015 actin filament binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0032432 actin filament bundle", "go_biological_process": "GO:0051017 actin filament bundle assembly;GO:0051639 actin filament network formation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7E3Q8-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BAA9-1", "uniprot_id": [ { "id": "E1BAA9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BAA9", "type": "external" } ], "mass": 69779.0, "length": 643, "protein_name": "Dual specificity phosphatase 16", "gene_name": "DUSP16", "organism": "Bovine", "refseq_name": "dual specificity protein phosphatase 16", "refseq_ac": [ { "id": "XP_024848387", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024848387", "type": "external" } ], "gene_names_uniprotkb": "DUSP16", "gene_names_refseq": "DUSP16", "protein_names_uniprotkb": "Dual specificity phosphatase 16", "protein_names_refseq": "dual specificity protein phosphatase 16", "tax_id": 9913, "disease": "", "pathway": " (bta:618644); (R-BTA-112409); (R-BTA-5675221)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity;GO:0048273 mitogen-activated protein kinase p38 binding;GO:0008330 protein tyrosine/threonine phosphatase activity;GO:0008432 JUN kinase binding;GO:0140597 protein carrier chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BAA9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB89-1", "uniprot_id": [ { "id": "FEM1C_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB89", "type": "external" } ], "mass": 68700.0, "length": 617, "protein_name": "Protein fem-1 homolog C", "gene_name": "FEM1C", "organism": "Bovine", "refseq_name": "protein fem-1 homolog C", "refseq_ac": [ { "id": "NP_001094689", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094689", "type": "external" } ], "gene_names_uniprotkb": "FEM1C", "gene_names_refseq": "FEM1C", "protein_names_uniprotkb": "Protein fem-1 homolog C; FEM1-gamma; FEM1c", "protein_names_refseq": "FEM1-gamma; protein fem-1 homolog C-like; protein fem-1 homolog C", "tax_id": 9913, "disease": "", "pathway": " (bta:541180); (R-BTA-8951664)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation. The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex;GO:0031462 Cul2-RING ubiquitin ligase complex", "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0140627 ubiquitin-dependent protein catabolic process via the C-end degron rule pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB89-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFK9-1", "uniprot_id": [ { "id": "STMN3_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFK9", "type": "external" } ], "mass": 21016.0, "length": 180, "protein_name": "Stathmin-3", "gene_name": "STMN3", "organism": "Bovine", "refseq_name": "stathmin-3", "refseq_ac": [ { "id": "NP_001077135", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077135", "type": "external" } ], "gene_names_uniprotkb": "STMN3", "gene_names_refseq": "STMN3", "protein_names_uniprotkb": "Stathmin-3", "protein_names_refseq": "stathmin-3; stathmin-like 3", "tax_id": 9913, "disease": "", "pathway": " (bta:511110)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exhibits microtubule-destabilizing activity, which is antagonized by STAT3., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030426 growth cone;GO:0043005 neuron projection", "go_biological_process": "GO:0031110 regulation of microtubule polymerization or depolymerization;GO:0031175 neuron projection development;GO:0007019 microtubule depolymerization;GO:0010977 negative regulation of neuron projection development;GO:0035021 negative regulation of Rac protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFK9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IF75-1", "uniprot_id": [ { "id": "TM182_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IF75", "type": "external" } ], "mass": 25928.0, "length": 229, "protein_name": "Transmembrane protein 182", "gene_name": "TMEM182", "organism": "Bovine", "refseq_name": "transmembrane protein 182 precursor", "refseq_ac": [ { "id": "NP_001077253", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077253", "type": "external" } ], "gene_names_uniprotkb": "TMEM182", "gene_names_refseq": "TMEM182", "protein_names_uniprotkb": "Transmembrane protein 182", "protein_names_refseq": "transmembrane protein 182 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:618298)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negatively regulates myogenesis and skeletal muscle regeneration via its association with ITGB1 (By similarity). Modulates ITGB1 activation by decreasing ITGB1-LAMB1 interaction and inhibiting ITGB1-mediated intracellular signaling during myogenesis (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007517 muscle organ development;GO:0045662 negative regulation of myoblast differentiation;GO:0014908 myotube differentiation involved in skeletal muscle regeneration;GO:0014906 myotube cell development involved in skeletal muscle regeneration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IF75-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B8C8-1", "uniprot_id": [ { "id": "E1B8C8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B8C8", "type": "external" } ], "mass": 51904.0, "length": 476, "protein_name": "FEZ family zinc finger 1", "gene_name": "FEZF1", "organism": "Bovine", "refseq_name": "fez family zinc finger protein 1", "refseq_ac": [ { "id": "NP_001192635", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192635", "type": "external" } ], "gene_names_uniprotkb": "FEZF1", "gene_names_refseq": "FEZF1", "protein_names_uniprotkb": "FEZ family zinc finger 1", "protein_names_refseq": "fez family zinc finger protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:511770)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B8C8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BAB4-1", "uniprot_id": [ { "id": "E1BAB4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BAB4", "type": "external" } ], "mass": 95437.0, "length": 872, "protein_name": "Metabotropic glutamate receptor 2", "gene_name": "GRM2", "organism": "Bovine", "refseq_name": "metabotropic glutamate receptor 2 precursor", "refseq_ac": [ { "id": "NP_001192795", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192795", "type": "external" } ], "gene_names_uniprotkb": "GRM2", "gene_names_refseq": "GRM2", "protein_names_uniprotkb": "Metabotropic glutamate receptor 2", "protein_names_refseq": "metabotropic glutamate receptor 2 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:519904); (R-BTA-418594); (R-BTA-420499)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate. Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling. Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0008066 glutamate receptor activity;GO:0005246 calcium channel regulator activity;GO:0001641 group II metabotropic glutamate receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098978 glutamatergic synapse;GO:0030425 dendrite;GO:0045211 postsynaptic membrane;GO:0098793 presynapse", "go_biological_process": "GO:0007216 G protein-coupled glutamate receptor signaling pathway;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:0099171 presynaptic modulation of chemical synaptic transmission", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BAB4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KN32-1", "uniprot_id": [ { "id": "ZNF34_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KN32", "type": "external" } ], "mass": 61997.0, "length": 543, "protein_name": "Zinc finger protein 34", "gene_name": "ZNF34", "organism": "Bovine", "refseq_name": "zinc finger protein 34", "refseq_ac": [ { "id": "NP_001076989", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076989", "type": "external" } ], "gene_names_uniprotkb": "ZNF34", "gene_names_refseq": "ZNF34", "protein_names_uniprotkb": "Zinc finger protein 34", "protein_names_refseq": "zinc finger protein 34", "tax_id": 9913, "disease": "", "pathway": " (bta:615905)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003677 DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KN32-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QL48-1", "uniprot_id": [ { "id": "IL34_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QL48", "type": "external" } ], "mass": 26294.0, "length": 234, "protein_name": "Interleukin-34", "gene_name": "IL34", "organism": "Bovine", "refseq_name": "interleukin-34 precursor", "refseq_ac": [ { "id": "NP_001093794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093794", "type": "external" } ], "gene_names_uniprotkb": "IL34", "gene_names_refseq": "C18H16ORF77; IL-34; IL34", "protein_names_uniprotkb": "Interleukin-34; IL-34", "protein_names_refseq": "Interleukin-34; interleukin-34 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:508292); (R-BTA-449836)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005157 macrophage colony-stimulating factor receptor binding;GO:0005125 cytokine activity;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0006954 inflammatory response;GO:0008284 positive regulation of cell population proliferation;GO:0045087 innate immune response;GO:0048714 positive regulation of oligodendrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QL48-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B902-1", "uniprot_id": [ { "id": "E1B902_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B902", "type": "external" } ], "mass": 96056.0, "length": 861, "protein_name": "Mitogen-activated protein kinase kinase kinase kinase", "gene_name": "MAP4K2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MAP4K2", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase kinase; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008349 MAP kinase kinase kinase kinase activity;GO:0031435 mitogen-activated protein kinase kinase kinase binding;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0046330 positive regulation of JNK cascade;GO:0006903 vesicle targeting", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B902-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7E3W5-1", "uniprot_id": [ { "id": "SNG2_BOVIN", "url": "https://www.uniprot.org/uniprot/A7E3W5", "type": "external" } ], "mass": 25139.0, "length": 224, "protein_name": "Synaptogyrin-2", "gene_name": "SYNGR2", "organism": "Bovine", "refseq_name": "synaptogyrin-2", "refseq_ac": [ { "id": "NP_001093828", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093828", "type": "external" } ], "gene_names_uniprotkb": "SYNGR2", "gene_names_refseq": "Cellugyrin; SYNGR2", "protein_names_uniprotkb": "Synaptogyrin-2; Cellugyrin", "protein_names_refseq": "synaptogyrin-2", "tax_id": 9913, "disease": "", "pathway": " (bta:513812)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031594 neuromuscular junction;GO:0030672 synaptic vesicle membrane;GO:0016020 membrane", "go_biological_process": "GO:0045055 regulated exocytosis;GO:0048499 synaptic vesicle membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7E3W5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B8X4-1", "uniprot_id": [ { "id": "E1B8X4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B8X4", "type": "external" } ], "mass": 61228.0, "length": 541, "protein_name": "NEDD8-activating enzyme E1 regulatory subunit", "gene_name": "NAE1", "organism": "Bovine", "refseq_name": "NEDD8-activating enzyme E1 regulatory subunit isoform X1", "refseq_ac": [ { "id": "XP_005218770", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005218770", "type": "external" } ], "gene_names_uniprotkb": "NAE1", "gene_names_refseq": "NAE1", "protein_names_uniprotkb": "NEDD8-activating enzyme E1 regulatory subunit", "protein_names_refseq": "NEDD8-activating enzyme E1 regulatory subunit isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019781 NEDD8 activating enzyme activity;GO:0046982 protein heterodimerization activity;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0032991 protein-containing complex", "go_biological_process": "GO:0045116 protein neddylation;GO:0051402 neuron apoptotic process;GO:0043523 regulation of neuron apoptotic process;GO:0033314 mitotic DNA replication checkpoint signaling;GO:0150052 regulation of postsynapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B8X4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUH1-1", "uniprot_id": [ { "id": "TOR2A_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUH1", "type": "external" } ], "mass": 36170.0, "length": 321, "protein_name": "Torsin-2A", "gene_name": "TOR2A", "organism": "Bovine", "refseq_name": "torsin-2A precursor", "refseq_ac": [ { "id": "NP_001076945", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076945", "type": "external" } ], "gene_names_uniprotkb": "TOR2A", "gene_names_refseq": "Prosalusin; TOR2A; Torsin-2A", "protein_names_uniprotkb": "Torsin-2A; Torsin family 2 member A", "protein_names_refseq": "torsin-2A precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:534311)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUH1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE13-1", "uniprot_id": [ { "id": "MAL2_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE13", "type": "external" } ], "mass": 19146.0, "length": 176, "protein_name": "Protein MAL2", "gene_name": "MAL2", "organism": "Bovine", "refseq_name": "protein MAL2", "refseq_ac": [ { "id": "NP_001075188", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075188", "type": "external" } ], "gene_names_uniprotkb": "MAL2", "gene_names_refseq": "MAL2", "protein_names_uniprotkb": "Protein MAL2", "protein_names_refseq": "protein MAL2", "tax_id": 9913, "disease": "", "pathway": " (bta:511940)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "41018975", "class_list": "", "function": "Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019911 structural constituent of myelin sheath", "go_cellular_component": "GO:0016020 membrane;GO:0016324 apical plasma membrane;GO:0045121 membrane raft", "go_biological_process": "GO:0042552 myelination", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A2VE13-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B853-1", "uniprot_id": [ { "id": "E1B853_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B853", "type": "external" } ], "mass": 34799.0, "length": 334, "protein_name": "Ventral anterior homeobox 1", "gene_name": "VAX1", "organism": "Bovine", "refseq_name": "ventral anterior homeobox 1", "refseq_ac": [ { "id": "NP_001178071", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178071", "type": "external" } ], "gene_names_uniprotkb": "VAX1", "gene_names_refseq": "VAX1", "protein_names_uniprotkb": "Ventral anterior homeobox 1", "protein_names_refseq": "ventral anterior homeobox 1", "tax_id": 9913, "disease": "", "pathway": " (bta:782056)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0031490 chromatin DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0007420 brain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B853-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLI0-1", "uniprot_id": [ { "id": "EPDR1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLI0", "type": "external" } ], "mass": 26485.0, "length": 236, "protein_name": "Mammalian ependymin-related protein 1", "gene_name": "EPDR1", "organism": "Bovine", "refseq_name": "mammalian ependymin-related protein 1 precursor", "refseq_ac": [ { "id": "NP_001095758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095758", "type": "external" } ], "gene_names_uniprotkb": "EPDR1; MERP1", "gene_names_refseq": "EPDR1; MERP-1", "protein_names_uniprotkb": "Mammalian ependymin-related protein 1; MERP-1", "protein_names_refseq": "ependymin related protein 1; mammalian ependymin-related protein 1 precursor; mammalian ependymin-related protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:615376)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds anionic lipids and gangliosides at acidic pH., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1905573 ganglioside GM1 binding;GO:0005543 phospholipid binding;GO:0042802 identical protein binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome;GO:0043202 lysosomal lumen", "go_biological_process": "GO:0007160 cell-matrix adhesion;GO:1990764 myofibroblast contraction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLI0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L5A6-1", "uniprot_id": [ { "id": "ADRM1_BOVIN", "url": "https://www.uniprot.org/uniprot/A1L5A6", "type": "external" } ], "mass": 41955.0, "length": 407, "protein_name": "Proteasomal ubiquitin receptor ADRM1", "gene_name": "ADRM1", "organism": "Bovine", "refseq_name": "proteasomal ubiquitin receptor ADRM1", "refseq_ac": [ { "id": "NP_001073751", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073751", "type": "external" } ], "gene_names_uniprotkb": "ADRM1", "gene_names_refseq": "ADRM1", "protein_names_uniprotkb": "Proteasomal ubiquitin receptor ADRM1; Rpn13 homolog", "protein_names_refseq": "adhesion regulating molecule 1; proteasomal ubiquitin receptor ADRM1; rpn13 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:519729); (R-BTA-1169091); (R-BTA-1234176); (R-BTA-1236978); (R-BTA-174084); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-187577); (R-BTA-195253); (R-BTA-202424); (R-BTA-2467813); (R-BTA-2871837); (R-BTA-349425); (R-BTA-350562); (R-BTA-382556); (R-BTA-450408); (R-BTA-4608870); (R-BTA-4641257); (R-BTA-4641258); (R-BTA-5358346); (R-BTA-5607761); (R-BTA-5607764); (R-BTA-5610780); (R-BTA-5610785); (R-BTA-5632684); (R-BTA-5668541); (R-BTA-5676590); (R-BTA-5687128); (R-BTA-5689603); (R-BTA-5689880); (R-BTA-68867); (R-BTA-68949); (R-BTA-69017); (R-BTA-69481); (R-BTA-69601); (R-BTA-75815); (R-BTA-8852276); (R-BTA-8854050); (R-BTA-8939236); (R-BTA-8939902); (R-BTA-8941858); (R-BTA-8948751); (R-BTA-8951664); (R-BTA-9020702); (R-BTA-9755511); (R-BTA-9762114); (R-BTA-9766229); (R-BTA-983168); (R-BTA-9907900); (R-BTA-9929356); (R-BTA-9929491); (R-BTA-9931269); (R-BTA-9932298); (R-BTA-9954709)", "pathway_count": 55, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061133 endopeptidase activator activity;GO:0070628 proteasome binding;GO:0002020 protease binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000502 proteasome complex;GO:0008541 proteasome regulatory particle, lid subcomplex;GO:0005654 nucleoplasm", "go_biological_process": "GO:0043248 proteasome assembly;GO:0006368 transcription elongation by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1L5A6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7B0-1", "uniprot_id": [ { "id": "E1B7B0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7B0", "type": "external" } ], "mass": 70775.0, "length": 631, "protein_name": "alpha-1,2-Mannosidase", "gene_name": "MAN1C1", "organism": "Bovine", "refseq_name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X1", "refseq_ac": [ { "id": "XP_002685752", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002685752", "type": "external" } ], "gene_names_uniprotkb": "MAN1C1", "gene_names_refseq": "MAN1C1", "protein_names_uniprotkb": "alpha-1,2-Mannosidase; 3.2.1.-", "protein_names_refseq": "mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:615012); (R-BTA-964827)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006491 N-glycan processing;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7B0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8WH74-1", "uniprot_id": [ { "id": "CD302_BOVIN", "url": "https://www.uniprot.org/uniprot/A8WH74", "type": "external" } ], "mass": 25972.0, "length": 232, "protein_name": "CD302 antigen", "gene_name": "CD302", "organism": "Bovine", "refseq_name": "CD302 antigen precursor", "refseq_ac": [ { "id": "NP_001103661", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103661", "type": "external" } ], "gene_names_uniprotkb": "CD302", "gene_names_refseq": "CD302; DCL-1", "protein_names_uniprotkb": "CD302 antigen; Type I transmembrane C-type lectin receptor DCL-1", "protein_names_refseq": "C-type lectin domain family 13 member A; CD302 antigen precursor; CD302 antigen; type I transmembrane C-type lectin receptor DCL-1", "tax_id": 9913, "disease": "", "pathway": " (bta:100126272)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17947679", "class_list": "", "function": "Multifunctional C-type lectin receptor involved in endocytosis, phagocytosis and regulation of cell adhesion and migration. Plays a critical role in guiding dendritic cells to lymph nodes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "A8YXZ1;F1MF05", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0005938 cell cortex;GO:0016020 membrane;GO:0030175 filopodium;GO:0005902 microvillus", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A8WH74-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJQ2-1", "uniprot_id": [ { "id": "SCAR5_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJQ2", "type": "external" } ], "mass": 53453.0, "length": 495, "protein_name": "Scavenger receptor class A member 5", "gene_name": "SCARA5", "organism": "Bovine", "refseq_name": "scavenger receptor class A member 5", "refseq_ac": [ { "id": "NP_001095969", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095969", "type": "external" } ], "gene_names_uniprotkb": "SCARA5", "gene_names_refseq": "SCARA5", "protein_names_uniprotkb": "Scavenger receptor class A member 5", "protein_names_refseq": "scavenger receptor class A member 5; scavenger receptor class A, member 5 (putative)", "tax_id": 9913, "disease": "", "pathway": " (bta:516087)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Preferentially binds ferritin light chain (FTL) compared to heavy chain (FTH1)., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 7, "predicted_n_glycosites": 7, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 7, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070287 ferritin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane", "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0006897 endocytosis;GO:0006879 intracellular iron ion homeostasis;GO:0070207 protein homotrimerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJQ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4D7S0-1", "uniprot_id": [ { "id": "WNT2_BOVIN", "url": "https://www.uniprot.org/uniprot/A4D7S0", "type": "external" } ], "mass": 40643.0, "length": 360, "protein_name": "Protein Wnt-2", "gene_name": "WNT2", "organism": "Bovine", "refseq_name": "protein Wnt-2 precursor", "refseq_ac": [ { "id": "NP_001013019", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013019", "type": "external" } ], "gene_names_uniprotkb": "WNT2", "gene_names_refseq": "WNT2", "protein_names_uniprotkb": "Protein Wnt-2", "protein_names_refseq": "protein Wnt-2 precursor; protein Wnt-2; wingless-type MMTV integration site family member 2", "tax_id": 9913, "disease": "", "pathway": " (bta:493729); (R-BTA-3238698)", "pathway_count": 2, "publication_count": 3, "publication_id_list": "12917688;22696613;25643727", "class_list": "", "function": "Ligand for members of the frizzled family of seven transmembrane receptors., [UniProtKB, UniProtKB]; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as a upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; These data demonstrate for the first time that FSH regulates CTNNB1 protein and WNT2 mRNA expressions in bovine granulosa cells, suggesting a potential role of canonical WNT signaling in ovarian steroidogenesis and follicular growth of cattle., [RefSeq, PubMed]; WNT2 gene is associated with resistance to paratuberculosis, [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005109 frizzled binding;GO:0005125 cytokine activity;GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0031012 extracellular matrix;GO:0005576 extracellular region", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0030182 neuron differentiation;GO:0071560 cellular response to transforming growth factor beta stimulus;GO:0048146 positive regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A4D7S0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B843-1", "uniprot_id": [ { "id": "E1B843_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B843", "type": "external" } ], "mass": 20368.0, "length": 178, "protein_name": "N-alpha-acetyltransferase 20", "gene_name": "NAA20", "organism": "Bovine", "refseq_name": "N-alpha-acetyltransferase 20", "refseq_ac": [ { "id": "NP_001193758", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193758", "type": "external" } ], "gene_names_uniprotkb": "NAA20", "gene_names_refseq": "NAA20; NAT5", "protein_names_uniprotkb": "N-alpha-acetyltransferase 20; 2.3.1.254; Methionine N-acetyltransferase; N-acetyltransferase 5; N-terminal acetyltransferase B complex catalytic subunit NAA20; N-terminal acetyltransferase B complex catalytic subunit NAT5; NatB catalytic subunit", "protein_names_refseq": "N-acetyltransferase 5 (GCN5-related, putative); N-alpha-acetyltransferase 20", "tax_id": 9913, "disease": "", "pathway": " (bta:540212)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.254", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.254", "type": "external" } ], "go_molecular_function": "GO:0120518 protein N-terminal-methionine acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0031416 NatB complex", "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B843-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUZ5-1", "uniprot_id": [ { "id": "SERC3_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUZ5", "type": "external" } ], "mass": 52418.0, "length": 472, "protein_name": "Serine incorporator 3", "gene_name": "SERINC3", "organism": "Bovine", "refseq_name": "serine incorporator 3", "refseq_ac": [ { "id": "NP_001076881", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076881", "type": "external" } ], "gene_names_uniprotkb": "SERINC3", "gene_names_refseq": "SERINC3", "protein_names_uniprotkb": "Serine incorporator 3", "protein_names_refseq": "serine incorporator 3", "tax_id": 9913, "disease": "", "pathway": " (bta:511861); (R-BTA-977347)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Restriction factor required to restrict infectivity of gammaretroviruses: acts by inhibiting an early step of viral infection. Impairs the penetration of the viral particle into the cytoplasm. Non-ATP-dependent, non-specific lipid transporter for phosphatidylserine, phosphatidylcholine, and phosphatidylethanolamine. Functions as a scramblase that flips lipids in both directions across the membrane. Phospholipid scrambling results in gammaretroviral surface exposure of phosphatidylserine and loss of membrane asymmetry, which leads to loss of infectivity., [UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" } ], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0017121 plasma membrane phospholipid scrambling;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUZ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPY8-1", "uniprot_id": [ { "id": "PIN4_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPY8", "type": "external" } ], "mass": 13903.0, "length": 131, "protein_name": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4", "gene_name": "PIN4", "organism": "Bovine", "refseq_name": "peptidyl-prolyl cis-trans isomerase NIMA-interacting 4", "refseq_ac": [ { "id": "NP_001099127", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099127", "type": "external" } ], "gene_names_uniprotkb": "PIN4", "gene_names_refseq": "PIN4; Par14", "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; 5.2.1.8; PPIase Pin4; Par14; Parvulin-14; Peptidyl-prolyl cis-trans isomerase Pin4; Rotamase Pin4", "protein_names_refseq": "PPIase Pin4; parvulin-14; parvulin; peptidyl-prolyl cis-trans isomerase NIMA-interacting 4; peptidyl-prolyl cis-trans isomerase Pin4; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin); protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin); protein NIMA-interacting, 4; rotamase Pin4", "tax_id": 9913, "disease": "", "pathway": " (bta:100126055)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QPY8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H7F2-1", "uniprot_id": [ { "id": "GPN2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H7F2", "type": "external" } ], "mass": 34464.0, "length": 310, "protein_name": "GPN-loop GTPase 2", "gene_name": "GPN2", "organism": "Bovine", "refseq_name": "GPN-loop GTPase 2", "refseq_ac": [ { "id": "NP_001092443", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092443", "type": "external" } ], "gene_names_uniprotkb": "GPN2; ATPBD1B", "gene_names_refseq": "ATPBD1B; GPN2", "protein_names_uniprotkb": "GPN-loop GTPase 2; 3.6.5.-; ATP-binding domain 1 family member B", "protein_names_refseq": "ATP binding domain 1 family, member B; GPN-loop GTPase 2", "tax_id": 9913, "disease": "", "pathway": " (bta:514772)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Small GTPase involved in the correct assembly of RNA polymerase RNA polymerase II and III (RNAPII and RNAPIII) complexes, ensuring their proper nuclear import., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H7F2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "C1JZ66-1", "uniprot_id": [ { "id": "IMA8_BOVIN", "url": "https://www.uniprot.org/uniprot/C1JZ66", "type": "external" } ], "mass": 57362.0, "length": 522, "protein_name": "Importin subunit alpha-8", "gene_name": "KPNA7", "organism": "Bovine", "refseq_name": "importin subunit alpha-8", "refseq_ac": [ { "id": "NP_001157419", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157419", "type": "external" } ], "gene_names_uniprotkb": "KPNA7", "gene_names_refseq": "KPNA7", "protein_names_uniprotkb": "Importin subunit alpha-8; Karyopherin subunit alpha-7", "protein_names_refseq": "importin alpha 8; importin subunit alpha-8; karyopherin 7; karyopherin alpha 7 (importin alpha 8)", "tax_id": 9913, "disease": "", "pathway": " (bta:789280)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "19420384;24257609", "class_list": "", "function": "Bovine ephemeral fever rhabdovirus alpha1 protein binds bovin importin beta1 and importin 7., [RefSeq, PubMed]; Functions in nuclear protein import., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; KPNA7: mRNA specifically expressed in ovary & mature oocyte; protein high in oocyte & early embryo but low in blastocyst; strong binding affinity for nucleoplasmin 2; KPNA7 knockdown in early embryos decreases embryo development; DNA & AA sequences, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MPD2", "ec_number_list": [], "go_molecular_function": "GO:0008139 nuclear localization sequence binding;GO:0061608 nuclear import signal receptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0042564 NLS-dependent protein nuclear import complex;GO:0005819 spindle", "go_biological_process": "GO:0006607 NLS-bearing protein import into nucleus;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "C1JZ66-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDU1-1", "uniprot_id": [ { "id": "SPY4_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDU1", "type": "external" } ], "mass": 32376.0, "length": 299, "protein_name": "Protein sprouty homolog 4", "gene_name": "SPRY4", "organism": "Bovine", "refseq_name": "protein sprouty homolog 4", "refseq_ac": [ { "id": "NP_001074981", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074981", "type": "external" } ], "gene_names_uniprotkb": "SPRY4", "gene_names_refseq": "SPRY4", "protein_names_uniprotkb": "Protein sprouty homolog 4; Spry-4", "protein_names_refseq": "protein sprouty homolog 4; sprouty homolog 4; spry-4", "tax_id": 9913, "disease": "", "pathway": " (bta:504593)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras (By similarity). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (By similarity). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0032587 ruffle membrane;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:1900025 negative regulation of substrate adhesion-dependent cell spreading;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway;GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDU1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "D7GLD0-1", "uniprot_id": [ { "id": "D7GLD0_BOVIN", "url": "https://www.uniprot.org/uniprot/D7GLD0", "type": "external" } ], "mass": 86340.0, "length": 757, "protein_name": "Mitofusin 2", "gene_name": "MFN2", "organism": "Bovine", "refseq_name": "mitofusin-2 isoform X1", "refseq_ac": [ { "id": "XP_024832092", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024832092", "type": "external" } ], "gene_names_uniprotkb": "MFN2", "gene_names_refseq": "MFN2", "protein_names_uniprotkb": "Mitofusin 2", "protein_names_refseq": "mitofusin-2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5205685); (R-BTA-9013419); (R-BTA-983231)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1BKT8", "ec_number_list": [], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0015630 microtubule cytoskeleton", "go_biological_process": "GO:0008053 mitochondrial fusion;GO:0046580 negative regulation of Ras protein signal transduction;GO:0006626 protein targeting to mitochondrion;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation;GO:0051646 mitochondrion localization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "D7GLD0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB70-1", "uniprot_id": [ { "id": "SEM3C_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB70", "type": "external" } ], "mass": 85237.0, "length": 751, "protein_name": "Semaphorin-3C", "gene_name": "SEMA3C", "organism": "Bovine", "refseq_name": "semaphorin-3C precursor", "refseq_ac": [ { "id": "NP_001094552", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094552", "type": "external" } ], "gene_names_uniprotkb": "SEMA3C", "gene_names_refseq": "SEMA3C", "protein_names_uniprotkb": "Semaphorin-3C", "protein_names_refseq": "Semaphorin-3C; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; semaphorin-3C precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:512660)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 6, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030215 semaphorin receptor binding;GO:0038191 neuropilin binding;GO:0045499 chemorepellent activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005576 extracellular region", "go_biological_process": "GO:0003350 pulmonary myocardium development;GO:0140074 cardiac endothelial to mesenchymal transition;GO:0030335 positive regulation of cell migration;GO:0071526 semaphorin-plexin signaling pathway;GO:0001755 neural crest cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB70-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB47-1", "uniprot_id": [ { "id": "CNOT9_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB47", "type": "external" } ], "mass": 33601.0, "length": 299, "protein_name": "CCR4-NOT transcription complex subunit 9", "gene_name": "CNOT9; PLCD4", "organism": "Bovine", "refseq_name": "CCR4-NOT transcription complex subunit 9", "refseq_ac": [ { "id": "NP_001094637", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094637", "type": "external" } ], "gene_names_uniprotkb": "CNOT9; PLCD4; RCD1; RQCD1", "gene_names_refseq": "CNOT9; RQCD1", "protein_names_uniprotkb": "CCR4-NOT transcription complex subunit 9; Cell differentiation protein RQCD1 homolog; Rcd-1", "protein_names_refseq": "CCR4-NOT transcription complex subunit 9; RCD1 required for cell differentiation1 homolog; cell differentiation protein RCD1 homolog; cell differentiation protein RQCD1 homolog; rcd-1", "tax_id": 9913, "disease": "", "pathway": " (bta:536537); (R-BTA-429947); (R-BTA-6804115)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation., [UniProtKB, UniProtKB]; Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding;GO:0120548 phosphatidylinositol phospholipase C activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0000932 P-body;GO:0030014 CCR4-NOT complex;GO:0030015 CCR4-NOT core complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0017148 negative regulation of translation;GO:0006402 mRNA catabolic process;GO:0031047 regulatory ncRNA-mediated gene silencing;GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB47-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK30-1", "uniprot_id": [ { "id": "ZN639_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK30", "type": "external" } ], "mass": 56105.0, "length": 485, "protein_name": "Zinc finger protein 639", "gene_name": "ZNF639", "organism": "Bovine", "refseq_name": "zinc finger protein 639", "refseq_ac": [ { "id": "NP_001092493", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092493", "type": "external" } ], "gene_names_uniprotkb": "ZNF639", "gene_names_refseq": "ZNF639", "protein_names_uniprotkb": "Zinc finger protein 639", "protein_names_refseq": "zinc finger protein 639", "tax_id": 9913, "disease": "", "pathway": " (bta:523536)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "17623809", "class_list": "", "function": "Binds DNA and may function as a transcriptional repressor., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A9X402", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030307 positive regulation of cell growth;GO:0045892 negative regulation of DNA-templated transcription;GO:0046718 symbiont entry into host cell", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PK30-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJZ5-1", "uniprot_id": [ { "id": "NUP93_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJZ5", "type": "external" } ], "mass": 93458.0, "length": 819, "protein_name": "Nuclear pore complex protein Nup93", "gene_name": "NUP93", "organism": "Bovine", "refseq_name": "nuclear pore complex protein Nup93", "refseq_ac": [ { "id": "NP_001092391", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092391", "type": "external" } ], "gene_names_uniprotkb": "NUP93", "gene_names_refseq": "NUP93", "protein_names_uniprotkb": "Nuclear pore complex protein Nup93; 93 kDa nucleoporin; Nucleoporin Nup93", "protein_names_refseq": "93 kDa nucleoporin; Nucleoporin Nup93; nuclear pore complex protein Nup93", "tax_id": 9913, "disease": "", "pathway": " (bta:510004); (R-BTA-159227); (R-BTA-159230); (R-BTA-159231); (R-BTA-159236); (R-BTA-1855170); (R-BTA-1855196); (R-BTA-1855229); (R-BTA-191859); (R-BTA-3108214); (R-BTA-3232142); (R-BTA-3301854); (R-BTA-3371453); (R-BTA-4085377); (R-BTA-4551638); (R-BTA-4570464); (R-BTA-4615885); (R-BTA-9615933)", "pathway_count": 18, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017056 structural constituent of nuclear pore", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005813 centrosome;GO:0031965 nuclear membrane;GO:0034399 nuclear periphery", "go_biological_process": "GO:0016973 poly(A)+ mRNA export from nucleus;GO:0006998 nuclear envelope organization;GO:0051292 nuclear pore complex assembly;GO:0060391 positive regulation of SMAD protein signal transduction;GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJZ5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJG7-1", "uniprot_id": [ { "id": "CCHL_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJG7", "type": "external" } ], "mass": 31069.0, "length": 275, "protein_name": "Holocytochrome c-type synthase", "gene_name": "HCCS", "organism": "Bovine", "refseq_name": "holocytochrome c-type synthase", "refseq_ac": [ { "id": "NP_001092356", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092356", "type": "external" } ], "gene_names_uniprotkb": "HCCS", "gene_names_refseq": "HCCS", "protein_names_uniprotkb": "Holocytochrome c-type synthase; 4.4.1.17; CCHL; Cytochrome c-type heme lyase", "protein_names_refseq": "CCHL; Cytochrome c-type heme lyase; cytochrome c heme-lyase; holocytochrome c-type synthase", "tax_id": 9913, "disease": "", "pathway": " (bta:506250); (R-BTA-611105)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.4.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.17", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004408 holocytochrome-c synthase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJG7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8E639-1", "uniprot_id": [ { "id": "F168B_BOVIN", "url": "https://www.uniprot.org/uniprot/A8E639", "type": "external" } ], "mass": 20284.0, "length": 195, "protein_name": "Myelin-associated neurite-outgrowth inhibitor", "gene_name": "FAM168B", "organism": "Bovine", "refseq_name": "myelin-associated neurite-outgrowth inhibitor", "refseq_ac": [ { "id": "NP_001103260", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103260", "type": "external" } ], "gene_names_uniprotkb": "FAM168B", "gene_names_refseq": "FAM168B", "protein_names_uniprotkb": "Myelin-associated neurite-outgrowth inhibitor; Mani", "protein_names_refseq": "mani; myelin-associated neurite-outgrowth inhibitor; protein FAM168B", "tax_id": 9913, "disease": "", "pathway": " (bta:505853)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibitor of neuronal axonal outgrowth. Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2. Positive regulator of CDC27., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "F1MAZ2", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8E639-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0JNQ7-1", "uniprot_id": [ { "id": "COL_BOVIN", "url": "https://www.uniprot.org/uniprot/A0JNQ7", "type": "external" } ], "mass": 12051.0, "length": 112, "protein_name": "Colipase", "gene_name": "CLPS", "organism": "Bovine", "refseq_name": "colipase precursor", "refseq_ac": [ { "id": "NP_001071435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071435", "type": "external" } ], "gene_names_uniprotkb": "CLPS", "gene_names_refseq": "CLPS", "protein_names_uniprotkb": "Colipase", "protein_names_refseq": "colipase precursor; colipase, pancreatic", "tax_id": 9913, "disease": "", "pathway": " (bta:525923); (R-BTA-192456); (R-BTA-975634)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase., [UniProtKB, UniProtKB]; Enterostatin has a biological activity as a satiety signal., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0035473 lipase binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0016042 lipid catabolic process;GO:0007586 digestion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0JNQ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0MTF4-1", "uniprot_id": [ { "id": "FGF5_BOVIN", "url": "https://www.uniprot.org/uniprot/A0MTF4", "type": "external" } ], "mass": 29641.0, "length": 270, "protein_name": "Fibroblast growth factor 5", "gene_name": "FGF5", "organism": "Bovine", "refseq_name": "fibroblast growth factor 5 precursor", "refseq_ac": [ { "id": "NP_001071479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001071479", "type": "external" } ], "gene_names_uniprotkb": "FGF5", "gene_names_refseq": "FGF-5; FGF3A; FGF5", "protein_names_uniprotkb": "Fibroblast growth factor 5; FGF-5", "protein_names_refseq": "fibroblast growth factor 3A; fibroblast growth factor 5 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:536771); (R-BTA-109704); (R-BTA-1257604); (R-BTA-190372); (R-BTA-190373); (R-BTA-190375); (R-BTA-5654219); (R-BTA-5654221); (R-BTA-5654227); (R-BTA-5654687); (R-BTA-5654688); (R-BTA-5654689); (R-BTA-5654693); (R-BTA-5654695); (R-BTA-5654699); (R-BTA-5654700); (R-BTA-5654704); (R-BTA-5654706); (R-BTA-5654710); (R-BTA-5654726); (R-BTA-5654727); (R-BTA-5654732); (R-BTA-5658623); (R-BTA-5673001); (R-BTA-6811558)", "pathway_count": 25, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008083 growth factor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0051781 positive regulation of cell division;GO:0030334 regulation of cell migration;GO:0022008 neurogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A0MTF4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A0RZB4-1", "uniprot_id": [ { "id": "SPRN_BOVIN", "url": "https://www.uniprot.org/uniprot/A0RZB4", "type": "external" } ], "mass": 13982.0, "length": 143, "protein_name": "Shadow of prion protein", "gene_name": "SPRN", "organism": "Bovine", "refseq_name": "shadow of prion protein precursor", "refseq_ac": [ { "id": "NP_001073790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073790", "type": "external" } ], "gene_names_uniprotkb": "SPRN", "gene_names_refseq": "SPRN", "protein_names_uniprotkb": "Shadow of prion protein; Protein shadoo", "protein_names_refseq": "protein shadoo; shadoo protein Sho; shadow of prion protein homolog; shadow of prion protein precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:616266); (R-BTA-163125)", "pathway_count": 2, "publication_count": 5, "publication_id_list": "17091316;17199895;22723200;23071594;35151978", "class_list": "", "function": "Genetic characterization of PRNP promoter indel variations and the polymorphism of open reading frames (ORFs) of PRNP and bovine prion-like Shadoo (SPRN) genes, are reported., [RefSeq, PubMed]; Post-transcriptional silencing of Bos taurus prion family genes and its impact on granulosa cell steroidogenesis., [RefSeq, PubMed]; Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP (By similarity)., [UniProtKB]; SPRN has the typical two-exon PRNP arrangement, with the CDS fully contained within exon 2; furthermore, it codes for a 143-amino-acid protein with 74.8% identity and 84.7% similarity with the human PRNP., [RefSeq, PubMed]; Sho as a non-PrP specific marker for prion infections, with obex as the best tissue source for the detection of Sho in transmissible spongiform encephalopathies rapid tests., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0098552 side of membrane", "go_biological_process": "GO:0006606 protein import into nucleus", "synthesized_glycan_count": 0, "hit_score": 0.6, "record_id": "A0RZB4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4H6-1", "uniprot_id": [ { "id": "DDX27_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4H6", "type": "external" } ], "mass": 87087.0, "length": 765, "protein_name": "Probable ATP-dependent RNA helicase DDX27", "gene_name": "DDX27", "organism": "Bovine", "refseq_name": "probable ATP-dependent RNA helicase DDX27", "refseq_ac": [ { "id": "NP_001073740", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073740", "type": "external" } ], "gene_names_uniprotkb": "DDX27", "gene_names_refseq": "DDX27", "protein_names_uniprotkb": "Probable ATP-dependent RNA helicase DDX27; 3.6.4.13; DEAD box protein 27", "protein_names_refseq": "DEAD (Asp-Glu-Ala-Asp) box polypeptide 27; DEAD box protein 27; probable ATP-dependent RNA helicase DDX27", "tax_id": 9913, "disease": "", "pathway": " (bta:514567)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003676 nucleic acid binding;GO:0003724 RNA helicase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005694 chromosome", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4H6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4H9-1", "uniprot_id": [ { "id": "LRRT1_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4H9", "type": "external" } ], "mass": 58660.0, "length": 521, "protein_name": "Leucine-rich repeat transmembrane neuronal protein 1", "gene_name": "LRRTM1", "organism": "Bovine", "refseq_name": "leucine-rich repeat transmembrane neuronal protein 1 precursor", "refseq_ac": [ { "id": "NP_001073773", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073773", "type": "external" } ], "gene_names_uniprotkb": "LRRTM1", "gene_names_refseq": "LRRTM1", "protein_names_uniprotkb": "Leucine-rich repeat transmembrane neuronal protein 1", "protein_names_refseq": "leucine-rich repeat transmembrane neuronal protein 1 precursor; leucine-rich repeat transmembrane neuronal protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:538452); (R-BTA-6794361)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0099634 postsynaptic specialization membrane", "go_biological_process": "GO:0051965 positive regulation of synapse assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4H9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4L4-1", "uniprot_id": [ { "id": "MINY4_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4L4", "type": "external" } ], "mass": 84447.0, "length": 763, "protein_name": "Probable ubiquitin carboxyl-terminal hydrolase MINDY-4", "gene_name": "MINDY4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MINDY4; FAM188B", "gene_names_refseq": "", "protein_names_uniprotkb": "Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; 3.4.19.12; Probable deubiquitinating enzyme MINDY-4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:615509)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity", "go_cellular_component": "", "go_biological_process": "GO:0006508 proteolysis;GO:0071108 protein K48-linked deubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4L4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4L6-1", "uniprot_id": [ { "id": "ETS2_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4L6", "type": "external" } ], "mass": 52654.0, "length": 470, "protein_name": "Protein C-ets-2", "gene_name": "ETS2", "organism": "Bovine", "refseq_name": "protein C-ets-2", "refseq_ac": [ { "id": "NP_001073683", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073683", "type": "external" } ], "gene_names_uniprotkb": "ETS2", "gene_names_refseq": "ETS2", "protein_names_uniprotkb": "Protein C-ets-2", "protein_names_refseq": "avian erythroblastosis virus E26 (v-ets) oncogene homolog 2; protein C-ets-2; v-ets erythroblastosis virus E26 oncogene homolog 2", "tax_id": 9913, "disease": "", "pathway": " (bta:281148); (R-BTA-2559585)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "18322277", "class_list": "", "function": "DLX3 has a central role in controlling IFNT gene expression by associating with ETS2 on the IFNT promoter., [RefSeq, PubMed]; Transcription factor activating transcription. Binds specifically the GGA DNA motif in gene promoters and stimulates transcription of those genes (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1A4L6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4P5-1", "uniprot_id": [ { "id": "PFD2_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4P5", "type": "external" } ], "mass": 16648.0, "length": 154, "protein_name": "Prefoldin subunit 2", "gene_name": "PFDN2", "organism": "Bovine", "refseq_name": "prefoldin subunit 2", "refseq_ac": [ { "id": "NP_001073690", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073690", "type": "external" } ], "gene_names_uniprotkb": "PFDN2", "gene_names_refseq": "PFDN2", "protein_names_uniprotkb": "Prefoldin subunit 2", "protein_names_refseq": "prefoldin subunit 2", "tax_id": 9913, "disease": "", "pathway": " (bta:404138)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0016272 prefoldin complex", "go_biological_process": "GO:0006457 protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4P5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1A4Q3-1", "uniprot_id": [ { "id": "HBM_BOVIN", "url": "https://www.uniprot.org/uniprot/A1A4Q3", "type": "external" } ], "mass": 15937.0, "length": 141, "protein_name": "Hemoglobin subunit mu", "gene_name": "HBM", "organism": "Bovine", "refseq_name": "hemoglobin subunit mu", "refseq_ac": [ { "id": "NP_001077237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077237", "type": "external" } ], "gene_names_uniprotkb": "HBM", "gene_names_refseq": "GLNE1; HBM", "protein_names_uniprotkb": "Hemoglobin subunit mu; Hemoglobin mu chain; Mu-globin", "protein_names_refseq": "globin E1; hemoglobin mu chain; hemoglobin subunit mu; hemoglobin, mu; mu-globin", "tax_id": 9913, "disease": "", "pathway": " (bta:100140603)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity", "go_cellular_component": "GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex", "go_biological_process": "GO:0048821 erythrocyte development;GO:0015671 oxygen transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A1A4Q3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L504-1", "uniprot_id": [ { "id": "LMF2_BOVIN", "url": "https://www.uniprot.org/uniprot/A1L504", "type": "external" } ], "mass": 79266.0, "length": 703, "protein_name": "Lipase maturation factor 2", "gene_name": "LMF2", "organism": "Bovine", "refseq_name": "lipase maturation factor 2", "refseq_ac": [ { "id": "NP_001032532", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032532", "type": "external" } ], "gene_names_uniprotkb": "LMF2", "gene_names_refseq": "BC002942; LMF2", "protein_names_uniprotkb": "Lipase maturation factor 2", "protein_names_refseq": "lipase maturation factor 2", "tax_id": 9913, "disease": "", "pathway": " (bta:510646)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Involved in the maturation of specific proteins in the endoplasmic reticulum. May be required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "Q32PH4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1L504-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L520-1", "uniprot_id": [ { "id": "ARFG2_BOVIN", "url": "https://www.uniprot.org/uniprot/A1L520", "type": "external" } ], "mass": 56758.0, "length": 520, "protein_name": "ADP-ribosylation factor GTPase-activating protein 2", "gene_name": "ARFGAP2", "organism": "Bovine", "refseq_name": "ADP-ribosylation factor GTPase-activating protein 2", "refseq_ac": [ { "id": "NP_001073696", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073696", "type": "external" } ], "gene_names_uniprotkb": "ARFGAP2; ZNF289", "gene_names_refseq": "ARFGAP2; ZNF289", "protein_names_uniprotkb": "ADP-ribosylation factor GTPase-activating protein 2; ARF GAP 2; Zinc finger protein 289", "protein_names_refseq": "ADP-ribosylation factor GTPase-activating protein 2; ARF GAP 2; zinc finger protein 289, ID1 regulated", "tax_id": 9913, "disease": "", "pathway": " (bta:505438)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1). Implicated in coatomer-mediated protein transport between the Golgi complex and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP may lead to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0000139 Golgi membrane", "go_biological_process": "GO:0048205 COPI coating of Golgi vesicle;GO:0015031 protein transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1L520-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A1L595-1", "uniprot_id": [ { "id": "K1C17_BOVIN", "url": "https://www.uniprot.org/uniprot/A1L595", "type": "external" } ], "mass": 48712.0, "length": 441, "protein_name": "Keratin, type I cytoskeletal 17", "gene_name": "KRT17", "organism": "Bovine", "refseq_name": "keratin, type I cytoskeletal 17", "refseq_ac": [ { "id": "NP_001098792", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098792", "type": "external" } ], "gene_names_uniprotkb": "KRT17", "gene_names_refseq": "KRT17", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 17; CK-17; Cytokeratin-17; K17; Keratin-17", "protein_names_refseq": "CK-17; K17; cytokeratin-17; keratin, type I cytoskeletal 17", "tax_id": 9913, "disease": "", "pathway": " (bta:281889)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Type I keratin involved in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial 'stem cells'. Acts as a promoter of epithelial proliferation by acting a regulator of immune response in skin: promotes Th1/Th17-dominated immune environment contributing to the development of basaloid skin tumors. May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 9, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5PJJ6", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0031069 hair follicle morphogenesis;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A1L595-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDL8-1", "uniprot_id": [ { "id": "SC23A_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDL8", "type": "external" } ], "mass": 86674.0, "length": 768, "protein_name": "Protein transport protein Sec23A", "gene_name": "SEC23A", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SEC23A", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein transport protein Sec23A; SEC23-related protein A", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:533994)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0070971 endoplasmic reticulum exit site;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0090110 COPII-coated vesicle cargo loading;GO:0006886 intracellular protein transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDL8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDP2-1", "uniprot_id": [ { "id": "PCMD1_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDP2", "type": "external" } ], "mass": 40474.0, "length": 356, "protein_name": "Protein-L-isoaspartate O-methyltransferase domain-containing protein 1", "gene_name": "PCMTD1", "organism": "Bovine", "refseq_name": "protein-L-isoaspartate O-methyltransferase domain-containing protein 1", "refseq_ac": [ { "id": "NP_001074995", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074995", "type": "external" } ], "gene_names_uniprotkb": "PCMTD1", "gene_names_refseq": "PCMTD1", "protein_names_uniprotkb": "Protein-L-isoaspartate O-methyltransferase domain-containing protein 1", "protein_names_refseq": "protein-L-isoaspartate O-methyltransferase domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:521261)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate recognition component of an ECS (Elongin BC-CUL5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Specifically binds to the methyltransferase cofactor S-adenosylmethionine (AdoMet) via the N-terminal AdoMet binding motif, but does not display methyltransferase activity. May provide an alternate maintenance pathway for modified proteins by acting as a damage-specific E3 ubiquitin ligase adaptor protein., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0004719 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0031466 Cul5-RING ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDP2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDP4-1", "uniprot_id": [ { "id": "ZN567_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDP4", "type": "external" } ], "mass": 75170.0, "length": 647, "protein_name": "Zinc finger protein 567", "gene_name": "ZNF567", "organism": "Bovine", "refseq_name": "zinc finger protein 567", "refseq_ac": [ { "id": "NP_001075068", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075068", "type": "external" } ], "gene_names_uniprotkb": "ZNF567", "gene_names_refseq": "ZNF567", "protein_names_uniprotkb": "Zinc finger protein 567", "protein_names_refseq": "zinc finger protein 567", "tax_id": 9913, "disease": "", "pathway": " (bta:532421)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDP4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDP5-1", "uniprot_id": [ { "id": "ENPP4_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDP5", "type": "external" } ], "mass": 51165.0, "length": 453, "protein_name": "Bis(5'-adenosyl)-triphosphatase ENPP4", "gene_name": "ENPP4", "organism": "Bovine", "refseq_name": "bis(5'-adenosyl)-triphosphatase ENPP4 precursor", "refseq_ac": [ { "id": "NP_001075004", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075004", "type": "external" } ], "gene_names_uniprotkb": "ENPP4", "gene_names_refseq": "E-NPP 4; ENPP4", "protein_names_uniprotkb": "Bis(5'-adenosyl)-triphosphatase ENPP4; 3.6.1.29; AP3A hydrolase; AP3Aase; E-NPP 4; Ectonucleotide pyrophosphatase/phosphodiesterase family member 4; NPP-4", "protein_names_refseq": "AP3A hydrolase; AP3Aase; E-NPP4; NPP-4; bis(5'-adenosyl)-triphosphatase ENPP4 precursor; bis(5'-adenosyl)-triphosphatase ENPP4; ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative function); ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative); ectonucleotide pyrophosphatase/phosphodiesterase family member 4", "tax_id": 9913, "disease": "", "pathway": " (bta:538583); (R-BTA-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.16.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2", "type": "external" }, { "id": "3.6.1.29", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.29", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "2.7.7.51", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.51", "type": "external" }, { "id": "3.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.2.1", "type": "external" }, { "id": "3.9.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.-", "type": "external" }, { "id": "3.2.1.20", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0047710 bis(5'-adenosyl)-triphosphatase activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007596 blood coagulation;GO:0030194 positive regulation of blood coagulation;GO:0046130 purine ribonucleoside catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDP5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDQ5-1", "uniprot_id": [ { "id": "NEUL_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDQ5", "type": "external" } ], "mass": 80728.0, "length": 704, "protein_name": "Neurolysin, mitochondrial", "gene_name": "NLN", "organism": "Bovine", "refseq_name": "neurolysin, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001029161", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001029161", "type": "external" } ], "gene_names_uniprotkb": "NLN", "gene_names_refseq": "EP24.16; NLN", "protein_names_uniprotkb": "Neurolysin, mitochondrial; 3.4.24.16; MEP; Microsomal endopeptidase; Mitochondrial oligopeptidase M; Neurotensin endopeptidase", "protein_names_refseq": "MEP; endopeptidase EC3.4.24.16; microsomal endopeptidase; mitochondrial oligopeptidase M; neurolysin (metallopeptidase M3 family); neurolysin, mitochondrial precursor; neurolysin, mitochondrial; neurotensin endopeptidase", "tax_id": 9913, "disease": "", "pathway": " (bta:538650)", "pathway_count": 1, "publication_count": 2, "publication_id_list": "14726412;17882707", "class_list": "", "function": "Ciliary epithelium expresses neurolysin., [RefSeq, PubMed]; Cyclic strain putatively regulates both the mRNA expression and enzymatic function of EP24.15 and EP24.16., [RefSeq, PubMed]; Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A. Acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A2VDQ5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDR9-1", "uniprot_id": [ { "id": "ZN750_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDR9", "type": "external" } ], "mass": 75167.0, "length": 703, "protein_name": "Zinc finger protein 750", "gene_name": "ZNF750", "organism": "Bovine", "refseq_name": "zinc finger protein 750", "refseq_ac": [ { "id": "NP_001075002", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075002", "type": "external" } ], "gene_names_uniprotkb": "ZNF750", "gene_names_refseq": "ZNF750", "protein_names_uniprotkb": "Zinc finger protein 750", "protein_names_refseq": "protein ZNF750; zinc finger protein 750", "tax_id": 9913, "disease": "", "pathway": " (bta:535628); (R-BTA-212436)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor involved in epidermis differentiation. Required for terminal epidermal differentiation: acts downstream of p63/TP63 and activates expression of late epidermal differentiation genes. Specifically binds to the promoter of KLF4 and promotes its expression (By similarity)., [UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990841 promoter-specific chromatin binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0008544 epidermis development;GO:0010719 negative regulation of epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDR9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDS1-1", "uniprot_id": [ { "id": "SCLY_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDS1", "type": "external" } ], "mass": 47204.0, "length": 437, "protein_name": "Selenocysteine lyase", "gene_name": "SCLY", "organism": "Bovine", "refseq_name": "selenocysteine lyase", "refseq_ac": [ { "id": "NP_001077273", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077273", "type": "external" } ], "gene_names_uniprotkb": "SCLY", "gene_names_refseq": "SCLY", "protein_names_uniprotkb": "Selenocysteine lyase; 4.4.1.16", "protein_names_refseq": "selenocysteine lyase", "tax_id": 9913, "disease": "", "pathway": " (bta:790815); (R-BTA-2408508)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.4.1.16", "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.16", "type": "external" } ], "go_molecular_function": "GO:0016740 transferase activity;GO:0009000 selenocysteine lyase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDS1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDW6-1", "uniprot_id": [ { "id": "NECA3_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDW6", "type": "external" } ], "mass": 40154.0, "length": 358, "protein_name": "N-terminal EF-hand calcium-binding protein 3", "gene_name": "NECAB3", "organism": "Bovine", "refseq_name": "N-terminal EF-hand calcium-binding protein 3", "refseq_ac": [ { "id": "NP_001075058", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075058", "type": "external" } ], "gene_names_uniprotkb": "NECAB3; APBA2BP; XB51", "gene_names_refseq": "NECAB3", "protein_names_uniprotkb": "N-terminal EF-hand calcium-binding protein 3; Amyloid-beta A4 protein-binding family A member 2-binding protein; X11L-binding protein 51", "protein_names_refseq": "N-terminal EF-hand calcium-binding protein 3; X11L-binding protein 51; amyloid beta A4 protein-binding family A member 2-binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:514695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta (By similarity). May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0000137 Golgi cis cisterna", "go_biological_process": "GO:0042984 regulation of amyloid precursor protein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDW6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDX7-1", "uniprot_id": [ { "id": "EXO5_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDX7", "type": "external" } ], "mass": 41511.0, "length": 370, "protein_name": "Exonuclease V", "gene_name": "EXO5", "organism": "Bovine", "refseq_name": "exonuclease V", "refseq_ac": [ { "id": "NP_001075077", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075077", "type": "external" } ], "gene_names_uniprotkb": "EXO5; DEM1", "gene_names_refseq": "C1orf176; DEM1; EXO5; Exo V", "protein_names_uniprotkb": "Exonuclease V; 3.1.-.-; Defects in morphology protein 1 homolog; Exo V", "protein_names_refseq": "defects in morphology 1 homolog; defects in morphology protein 1 homolog; exonuclease V; probable exonuclease V", "tax_id": 9913, "disease": "", "pathway": " (bta:538883)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MR90", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:0036297 interstrand cross-link repair", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2VDX7-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDY3-1", "uniprot_id": [ { "id": "CHM4A_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDY3", "type": "external" } ], "mass": 24948.0, "length": 222, "protein_name": "Charged multivesicular body protein 4a", "gene_name": "CHMP4A", "organism": "Bovine", "refseq_name": "charged multivesicular body protein 4a", "refseq_ac": [ { "id": "NP_001121976", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121976", "type": "external" } ], "gene_names_uniprotkb": "CHMP4A", "gene_names_refseq": "CHMP4A", "protein_names_uniprotkb": "Charged multivesicular body protein 4a; CHMP4a; Chromatin-modifying protein 4a", "protein_names_refseq": "charged multivesicular body protein 4a; chromatin modifying protein 4A; chromatin-modifying protein 4a", "tax_id": 9913, "disease": "", "pathway": " (bta:613647); (R-BTA-1632852); (R-BTA-5620971); (R-BTA-917729); (R-BTA-9668328)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. When overexpressed, membrane-assembled circular arrays of CHMP4A filaments can promote or stabilize negative curvature and outward budding. CHMP4A/B/C are required for the exosomal release of SDCBP, CD63 and syndecan (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding", "go_cellular_component": "GO:0000815 ESCRT III complex;GO:0005635 nuclear envelope;GO:0031902 late endosome membrane;GO:0009898 cytoplasmic side of plasma membrane;GO:0005771 multivesicular body", "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0015031 protein transport;GO:0006900 vesicle budding from membrane;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDY3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VDY4-1", "uniprot_id": [ { "id": "HPF1_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VDY4", "type": "external" } ], "mass": 39091.0, "length": 346, "protein_name": "Histone PARylation factor 1", "gene_name": "HPF1", "organism": "Bovine", "refseq_name": "histone PARylation factor 1", "refseq_ac": [ { "id": "NP_001075062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075062", "type": "external" } ], "gene_names_uniprotkb": "HPF1", "gene_names_refseq": "C4orf27; C8H4orf27; HPF1", "protein_names_uniprotkb": "Histone PARylation factor 1", "protein_names_refseq": "UPF0609 protein C4orf27 homolog; histone PARylation factor 1", "tax_id": 9913, "disease": "", "pathway": " (bta:525698)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cofactor for serine ADP-ribosylation that confers serine specificity on PARP1 and PARP2 and plays a key role in DNA damage response. Initiates the repair of double-strand DNA breaks: recruited to DNA damage sites by PARP1 and PARP2 and switches the amino acid specificity of PARP1 and PARP2 from aspartate or glutamate to serine residues, licensing serine ADP-ribosylation of target proteins. Serine ADP-ribosylation of target proteins, such as histones, promotes decompaction of chromatin and the recruitment of repair factors leading to the reparation of DNA strand breaks. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. HPF1 acts by completing the active site of PARP1 and PARP2: forms a composite active site composed of residues from HPF1 and PARP1 or PARP2. While HPF1 promotes the initiation of serine ADP-ribosylation, it restricts the polymerase activity of PARP1 and PARP2 in order to limit the length of poly-ADP-ribose chains. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0072572 poly-ADP-D-ribose binding;GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0140768 protein ADP-ribosyltransferase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0090734 site of DNA damage;GO:0005694 chromosome", "go_biological_process": "GO:0006974 DNA damage response;GO:0006302 double-strand break repair;GO:0140861 DNA repair-dependent chromatin remodeling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VDY4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE04-1", "uniprot_id": [ { "id": "FRRS1_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE04", "type": "external" } ], "mass": 65660.0, "length": 591, "protein_name": "Ferric reductase 1", "gene_name": "FRRS1", "organism": "Bovine", "refseq_name": "ferric reductase 1 precursor", "refseq_ac": [ { "id": "NP_001077164", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077164", "type": "external" } ], "gene_names_uniprotkb": "FRRS1", "gene_names_refseq": "FRRS1", "protein_names_uniprotkb": "Ferric reductase 1; 1.-.-.-", "protein_names_refseq": "ferric reductase 1 precursor; ferric reductase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:516522)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ferric reductase that reduces Fe(3+) to Fe(2+) and could play a role in iron import into cells. The electron donor and therefore the reaction mechanism are not known., [UniProtKB, UniProtKB]", "predicted_glycosites": 6, "predicted_n_glycosites": 5, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 6, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016722 oxidoreductase activity, acting on metal ions", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VE04-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE36-1", "uniprot_id": [ { "id": "PRS45_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE36", "type": "external" } ], "mass": 35251.0, "length": 316, "protein_name": "Serine protease 45", "gene_name": "PRSS45", "organism": "Bovine", "refseq_name": "serine protease 45 precursor", "refseq_ac": [ { "id": "NP_001075924", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075924", "type": "external" } ], "gene_names_uniprotkb": "PRSS45; TESSP5", "gene_names_refseq": "PRSS45; TESSP5", "protein_names_uniprotkb": "Serine protease 45; 3.4.21.-; Testis serine protease 5", "protein_names_refseq": "serine protease 45 precursor; serine protease 45; testis serine protease 5", "tax_id": 9913, "disease": "", "pathway": " (bta:540798)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VE36-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE47-1", "uniprot_id": [ { "id": "ADPGK_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE47", "type": "external" } ], "mass": 54086.0, "length": 497, "protein_name": "ADP-dependent glucokinase", "gene_name": "ADPGK", "organism": "Bovine", "refseq_name": "ADP-dependent glucokinase precursor", "refseq_ac": [ { "id": "NP_001075907", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075907", "type": "external" } ], "gene_names_uniprotkb": "ADPGK", "gene_names_refseq": "ADP-GK; ADPGK", "protein_names_uniprotkb": "ADP-dependent glucokinase; 2.7.1.147; ADP-GK; ADPGK", "protein_names_refseq": "ADP-dependent glucokinase precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:518158); (R-BTA-70171)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the phosphorylation of D-glucose to D-glucose 6-phosphate using ADP as the phosphate donor. GDP and CDP can replace ADP, but with reduced efficiency (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.147", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.147", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0043843 ADP-specific glucokinase activity", "go_cellular_component": "GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0006006 glucose metabolic process;GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VE47-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE55-1", "uniprot_id": [ { "id": "S35D2_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE55", "type": "external" } ], "mass": 39280.0, "length": 355, "protein_name": "Nucleotide sugar transporter SLC35D2", "gene_name": "SLC35D2", "organism": "Bovine", "refseq_name": "nucleotide sugar transporter SLC35D2", "refseq_ac": [ { "id": "NP_001075928", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075928", "type": "external" } ], "gene_names_uniprotkb": "SLC35D2", "gene_names_refseq": "SLC35D1; SLC35D2", "protein_names_uniprotkb": "Nucleotide sugar transporter SLC35D2; Solute carrier family 35 member D2", "protein_names_refseq": "UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter; nucleotide sugar transporter SLC35D2; solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1; solute carrier family 35 member D2", "tax_id": 9913, "disease": "", "pathway": " (bta:613734); (R-BTA-173599); (R-BTA-727802)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Nucleotide sugar antiporter transporting UDP-N-acetylglucosamine (UDP-GlcNAc) and UDP-glucose (UDP-Glc) from the cytosol into the lumen of the Golgi in exchange of UMP. By supplying UDP-N-acetylglucosamine, a donor substrate to heparan sulfate synthases, probably takes part in the synthesis of these glycoconjugates., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015297 antiporter activity;GO:0005338 nucleotide-sugar transmembrane transporter activity;GO:0005461 UDP-glucuronate transmembrane transporter activity;GO:0005462 UDP-N-acetylglucosamine transmembrane transporter activity;GO:0005463 UDP-N-acetylgalactosamine transmembrane transporter activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0015780 nucleotide-sugar transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VE55-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE58-1", "uniprot_id": [ { "id": "SNG3_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE58", "type": "external" } ], "mass": 24499.0, "length": 229, "protein_name": "Synaptogyrin-3", "gene_name": "SYNGR3", "organism": "Bovine", "refseq_name": "synaptogyrin-3", "refseq_ac": [ { "id": "NP_001075933", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075933", "type": "external" } ], "gene_names_uniprotkb": "SYNGR3", "gene_names_refseq": "SYNGR3", "protein_names_uniprotkb": "Synaptogyrin-3", "protein_names_refseq": "synaptogyrin-3", "tax_id": 9913, "disease": "", "pathway": " (bta:618415)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in regulated exocytosis. May indirectly regulate the activity of the plasma membrane dopamine transporter SLC6A3 and thereby regulate dopamine transport back from the synaptic cleft into the presynaptic terminal., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0031594 neuromuscular junction;GO:0030672 synaptic vesicle membrane;GO:0008021 synaptic vesicle", "go_biological_process": "GO:0045055 regulated exocytosis;GO:0032411 positive regulation of transporter activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VE58-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE61-1", "uniprot_id": [ { "id": "CLP1L_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE61", "type": "external" } ], "mass": 62101.0, "length": 538, "protein_name": "Lipid scramblase CLPTM1L", "gene_name": "CLPTM1L", "organism": "Bovine", "refseq_name": "lipid scramblase CLPTM1L", "refseq_ac": [ { "id": "NP_001075895", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075895", "type": "external" } ], "gene_names_uniprotkb": "CLPTM1L", "gene_names_refseq": "CLPTM1L; CRR9p", "protein_names_uniprotkb": "Lipid scramblase CLPTM1L; CLPTM1-like protein; CRR9p; Cisplatin resistance-related protein 9; Cleft lip and palate transmembrane protein 1-like protein", "protein_names_refseq": "CLPTM1-like protein; Cleft lip and palate transmembrane protein 1-like protein; cisplatin resistance related protein CRR9p; cisplatin resistance-related protein 9; lipid scramblase CLPTM1L", "tax_id": 9913, "disease": "", "pathway": " (bta:506200)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017128 phospholipid scramblase activity", "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system", "go_biological_process": "GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VE61-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE67-1", "uniprot_id": [ { "id": "CXB2_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE67", "type": "external" } ], "mass": 26194.0, "length": 226, "protein_name": "Gap junction beta-2 protein", "gene_name": "GJB2", "organism": "Bovine", "refseq_name": "gap junction beta-2 protein", "refseq_ac": [ { "id": "NP_001077106", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077106", "type": "external" } ], "gene_names_uniprotkb": "GJB2", "gene_names_refseq": "CX26; GJB2", "protein_names_uniprotkb": "Gap junction beta-2 protein; Connexin-26; Cx26", "protein_names_refseq": "connexin 26 protein; connexin-26; gap junction beta-2 protein; gap junction protein, beta 2, 26kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:407154); (R-BTA-190872)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16310041", "class_list": "", "function": "Intermediate invasive status of bovine trophoblast is supported by the fact that trophoblast giant cells coexpress connexins (Cx)26, Cx32, and Cx43, [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:1903763 gap junction channel activity involved in cell communication by electrical coupling;GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling;GO:0007605 sensory perception of sound;GO:0048839 inner ear development;GO:0016264 gap junction assembly;GO:1990349 gap junction-mediated intercellular transport", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A2VE67-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A2VE78-1", "uniprot_id": [ { "id": "FBXL5_BOVIN", "url": "https://www.uniprot.org/uniprot/A2VE78", "type": "external" } ], "mass": 78412.0, "length": 691, "protein_name": "F-box/LRR-repeat protein 5", "gene_name": "FBXL5", "organism": "Bovine", "refseq_name": "F-box/LRR-repeat protein 5", "refseq_ac": [ { "id": "NP_001075909", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075909", "type": "external" } ], "gene_names_uniprotkb": "FBXL5", "gene_names_refseq": "FBXL5", "protein_names_uniprotkb": "F-box/LRR-repeat protein 5; F-box and leucine-rich repeat protein 5", "protein_names_refseq": "F-box/LRR-repeat protein 5", "tax_id": 9913, "disease": "", "pathway": " (bta:519695); (R-BTA-8951664); (R-BTA-917937); (R-BTA-983168)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The C-terminal domain of FBXL5 contains a redox-sensitive [2Fe-2S] cluster that, upon oxidation, promotes binding to IRP2 to effect its oxygen-dependent degradation. Under iron deficiency conditions, the N-terminal hemerythrin-like (Hr) region, which contains a diiron metal center, cannot bind iron and undergoes conformational changes that destabilize the FBXL5 protein and cause its ubiquitination and degradation. When intracellular iron levels start rising, the Hr region is stabilized. Additional increases in iron levels facilitate the assembly and incorporation of a redox active [2Fe-2S] cluster in the C-terminal domain. Only when oxygen level is high enough to maintain the cluster in its oxidized state can FBXL5 recruit IRP2 as a substrate for polyubiquitination and degradation. Promotes ubiquitination and subsequent degradation of the dynactin complex component DCTN1. Within the nucleus, promotes the ubiquitination of SNAI1; preventing its interaction with DNA and promoting its degradation. Negatively regulates DNA damage response by mediating the ubiquitin-proteasome degradation of the DNA repair protein NABP2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005506 iron ion binding;GO:0051536 iron-sulfur cluster binding", "go_cellular_component": "GO:0005634 nucleus;GO:0048471 perinuclear region of cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0016567 protein ubiquitination;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A2VE78-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KMV8-1", "uniprot_id": [ { "id": "RBP10_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KMV8", "type": "external" } ], "mass": 67249.0, "length": 620, "protein_name": "Ran-binding protein 10", "gene_name": "RANBP10", "organism": "Bovine", "refseq_name": "ran-binding protein 10", "refseq_ac": [ { "id": "NP_001091594", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091594", "type": "external" } ], "gene_names_uniprotkb": "RANBP10", "gene_names_refseq": "RANBP10", "protein_names_uniprotkb": "Ran-binding protein 10; RanBP10", "protein_names_refseq": "ran-binding protein 10", "tax_id": 9913, "disease": "", "pathway": " (bta:519736)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation (By similarity). Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0005085 guanyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0034657 GID complex", "go_biological_process": "GO:0007010 cytoskeleton organization;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KMV8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KMW7-1", "uniprot_id": [ { "id": "MAP10_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KMW7", "type": "external" } ], "mass": 100058.0, "length": 912, "protein_name": "Microtubule-associated protein 10", "gene_name": "MAP10", "organism": "Bovine", "refseq_name": "microtubule-associated protein 10", "refseq_ac": [ { "id": "NP_001091617", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091617", "type": "external" } ], "gene_names_uniprotkb": "MAP10", "gene_names_refseq": "MAP10", "protein_names_uniprotkb": "Microtubule-associated protein 10; Microtubule regulator of 120 KDa", "protein_names_refseq": "microtubule regulator of 120 KDa; microtubule-associated protein 10", "tax_id": 9913, "disease": "", "pathway": " (bta:781199)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005813 centrosome;GO:0030496 midbody;GO:0005881 cytoplasmic microtubule;GO:0097431 mitotic spindle pole;GO:1990023 mitotic spindle midzone", "go_biological_process": "GO:0051301 cell division;GO:0032886 regulation of microtubule-based process;GO:0032467 positive regulation of cytokinesis;GO:0051256 mitotic spindle midzone assembly;GO:0031122 cytoplasmic microtubule organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KMW7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KN33-1", "uniprot_id": [ { "id": "EGFLA_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KN33", "type": "external" } ], "mass": 111405.0, "length": 1018, "protein_name": "Pikachurin", "gene_name": "EGFLAM", "organism": "Bovine", "refseq_name": "pikachurin precursor", "refseq_ac": [ { "id": "NP_001076947", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076947", "type": "external" } ], "gene_names_uniprotkb": "EGFLAM", "gene_names_refseq": "EGFLAM", "protein_names_uniprotkb": "Pikachurin; EGF-like, fibronectin type-III and laminin G-like domain-containing protein", "protein_names_refseq": "EGF-like, fibronectin type-III and laminin G-like domain-containing protein; pikachurin precursor; pikachurin", "tax_id": 9913, "disease": "", "pathway": " (bta:534427)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Plays a key role in the synaptic organization of photoreceptors by mediating transsynaptic interaction between alpha-dystroglycan and GPR179 on the postsynaptic membrane. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0048786 presynaptic active zone;GO:0043083 synaptic cleft;GO:0005604 basement membrane", "go_biological_process": "GO:0007165 signal transduction;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KN33-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A3KN46-1", "uniprot_id": [ { "id": "LTMD1_BOVIN", "url": "https://www.uniprot.org/uniprot/A3KN46", "type": "external" } ], "mass": 41913.0, "length": 360, "protein_name": "LETM1 domain-containing protein 1", "gene_name": "LETMD1", "organism": "Bovine", "refseq_name": "LETM1 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001076899", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076899", "type": "external" } ], "gene_names_uniprotkb": "LETMD1", "gene_names_refseq": "LETMD1", "protein_names_uniprotkb": "LETM1 domain-containing protein 1", "protein_names_refseq": "LETM1 domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:514595)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes. In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (By similarity). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (By similarity). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043022 ribosome binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005743 mitochondrial inner membrane", "go_biological_process": "GO:0007005 mitochondrion organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A3KN46-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUD6-1", "uniprot_id": [ { "id": "ELMO2_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUD6", "type": "external" } ], "mass": 82589.0, "length": 720, "protein_name": "Engulfment and cell motility protein 2", "gene_name": "ELMO2", "organism": "Bovine", "refseq_name": "engulfment and cell motility protein 2", "refseq_ac": [ { "id": "NP_001076860", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076860", "type": "external" } ], "gene_names_uniprotkb": "ELMO2", "gene_names_refseq": "ELMO2", "protein_names_uniprotkb": "Engulfment and cell motility protein 2", "protein_names_refseq": "engulfment and cell motility protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:508361)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates the activity of DOCK guanine nucleotide exchange factors (GEFs). Acts in association with DOCK1, DOCK2, DOCK4 and CRK. Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017124 SH3 domain binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0007015 actin filament organization;GO:0006909 phagocytosis;GO:0006915 apoptotic process;GO:0060326 cell chemotaxis;GO:0048870 cell motility", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUD6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUG7-1", "uniprot_id": [ { "id": "NUD17_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUG7", "type": "external" } ], "mass": 32389.0, "length": 302, "protein_name": "m7GpppN-mRNA hydrolase NUDT17", "gene_name": "NUDT17", "organism": "Bovine", "refseq_name": "m7GpppN-mRNA hydrolase NUDT17", "refseq_ac": [ { "id": "NP_001076852", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076852", "type": "external" } ], "gene_names_uniprotkb": "NUDT17", "gene_names_refseq": "NUDT17", "protein_names_uniprotkb": "m7GpppN-mRNA hydrolase NUDT17; 3.6.1.62; Nucleoside diphosphate-linked moiety X motif 17; Nudix motif 17", "protein_names_refseq": "m7GpppN-mRNA hydrolase NUDT17; nucleoside diphosphate-linked moiety X motif 17; nudix (nucleoside diphosphate linked moiety X)-type motif 17; nudix motif 17", "tax_id": 9913, "disease": "", "pathway": " (bta:507315)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a decapping enzyme capable of hydrolyzing monomethylated capped RNAs (in vitro). Hydrolyzes monomethylated capped RNA after alpha and beta phosphates to form N(7)-methyl-GDP. Shows low activity towards unmethylated capped RNA., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.6.1.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.64", "type": "external" }, { "id": "3.6.1.59", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59", "type": "external" }, { "id": "3.6.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.52", "type": "external" }, { "id": "3.6.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.10", "type": "external" }, { "id": "3.6.1.61", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.61", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0035529 NADH pyrophosphatase activity;GO:0140933 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0019677 NAD+ catabolic process;GO:0006742 NADP+ catabolic process;GO:0110154 RNA decapping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUG7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FUH5-1", "uniprot_id": [ { "id": "NDUF4_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FUH5", "type": "external" } ], "mass": 20108.0, "length": 175, "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4", "gene_name": "NDUFAF4", "organism": "Bovine", "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4", "refseq_ac": [ { "id": "NP_001076985", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076985", "type": "external" } ], "gene_names_uniprotkb": "NDUFAF4; HRPAP20", "gene_names_refseq": "C9H6ORF66; HRPAP20; NDUFAF4", "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Hormone-regulated proliferation-associated protein of 20 kDa", "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 4; NADH dehydrogenase (ubiquinone) complex I, assembly factor 4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Protein HRPAP20; hormone-regulated proliferation-associated protein of 20 kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:615440); (R-BTA-6799198)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0051607 defense response to virus;GO:0032981 mitochondrial respiratory chain complex I assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FUH5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV14-1", "uniprot_id": [ { "id": "MB211_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV14", "type": "external" } ], "mass": 40956.0, "length": 359, "protein_name": "Putative nucleotidyltransferase MAB21L1", "gene_name": "MAB21L1", "organism": "Bovine", "refseq_name": "putative nucleotidyltransferase MAB21L1", "refseq_ac": [ { "id": "NP_001091579", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091579", "type": "external" } ], "gene_names_uniprotkb": "MAB21L1", "gene_names_refseq": "MAB21L1", "protein_names_uniprotkb": "Putative nucleotidyltransferase MAB21L1; 2.7.7.-; Protein mab-21-like 1", "protein_names_refseq": "protein mab-21-like 1; putative nucleotidyltransferase MAB21L1", "tax_id": 9913, "disease": "", "pathway": " (bta:540081)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative nucleotidyltransferase required for several aspects of embryonic development including normal development of the eye (By similarity). It is unclear whether it displays nucleotidyltransferase activity in vivo. Binds single-stranded RNA (ssRNA) (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0016779 nucleotidyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0001654 eye development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV14-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV29-1", "uniprot_id": [ { "id": "BRM1L_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV29", "type": "external" } ], "mass": 37629.0, "length": 323, "protein_name": "Breast cancer metastasis-suppressor 1-like protein", "gene_name": "BRMS1L", "organism": "Bovine", "refseq_name": "breast cancer metastasis-suppressor 1-like protein", "refseq_ac": [ { "id": "NP_001076897", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076897", "type": "external" } ], "gene_names_uniprotkb": "BRMS1L", "gene_names_refseq": "BRMS1L", "protein_names_uniprotkb": "Breast cancer metastasis-suppressor 1-like protein", "protein_names_refseq": "breast cancer metastasis-suppressor 1 like; breast cancer metastasis-suppressor 1-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:514432)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the histone deacetylase (HDAC1)-dependent transcriptional repression activity. When overexpressed in lung cancer cell line that lacks p53/TP53 expression, inhibits cell growth (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0070822 Sin3-type complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV29-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV37-1", "uniprot_id": [ { "id": "CAVN3_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV37", "type": "external" } ], "mass": 27487.0, "length": 260, "protein_name": "Caveolae-associated protein 3", "gene_name": "CAVIN3", "organism": "Bovine", "refseq_name": "caveolae-associated protein 3", "refseq_ac": [ { "id": "NP_001076870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076870", "type": "external" } ], "gene_names_uniprotkb": "CAVIN3; PRKCDBP", "gene_names_refseq": "CAVIN3; PRKCDBP", "protein_names_uniprotkb": "Caveolae-associated protein 3; Cavin-3; Protein kinase C delta-binding protein", "protein_names_refseq": "caveolae-associated protein 3; cavin-3; protein kinase C delta binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:510203)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates the traffic and/or budding of caveolae. Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in smooth muscle but not in the lung and heart endothelial cells. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by promoting the rapid release of caveolae from the cell surface. Plays a role in the regulation of the circadian clock. Modulates the period length and phase of circadian gene expression and also regulates expression and interaction of the core clock components PER1/2 and CRY1/2., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005080 protein kinase C binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005901 caveola;GO:0032991 protein-containing complex", "go_biological_process": "GO:0032922 circadian regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV37-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV42-1", "uniprot_id": [ { "id": "MT21A_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV42", "type": "external" } ], "mass": 24484.0, "length": 218, "protein_name": "Protein N-lysine methyltransferase METTL21A", "gene_name": "METTL21A", "organism": "Bovine", "refseq_name": "protein N-lysine methyltransferase METTL21A", "refseq_ac": [ { "id": "NP_001076987", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076987", "type": "external" } ], "gene_names_uniprotkb": "METTL21A; FAM119A", "gene_names_refseq": "FAM119A; METTL21A", "protein_names_uniprotkb": "Protein N-lysine methyltransferase METTL21A; 2.1.1.-; Methyltransferase-like protein 21A", "protein_names_refseq": "family with sequence similarity 119, member A; methyltransferase like 21A; methyltransferase-like protein 21A; protein N-lysine methyltransferase METTL21A; protein-lysine methyltransferase METTL21A", "tax_id": 9913, "disease": "", "pathway": " (bta:615773); (R-BTA-8876725)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein-lysine methyltransferase that selectively trimethylates residues in heat shock protein 70 (HSP70) family members. Contributes to the in vivo trimethylation of Lys residues in HSPA1 and HSPA8. In vitro methylates 'Lys-561' in HSPA1, 'Lys-564' in HSPA2, 'Lys-585' in HSPA5, 'Lys-563' in HSPA6 and 'Lys-561' in HSPA8., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.372", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity;GO:0008168 methyltransferase activity;GO:0051117 ATPase binding;GO:0030544 Hsp70 protein binding", "go_cellular_component": "GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006479 protein methylation;GO:0032259 methylation;GO:1903333 negative regulation of protein folding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV42-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV58-1", "uniprot_id": [ { "id": "CIAO3_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV58", "type": "external" } ], "mass": 52606.0, "length": 476, "protein_name": "Cytosolic iron-sulfur assembly component 3", "gene_name": "CIAO3", "organism": "Bovine", "refseq_name": "cytosolic iron-sulfur assembly component 3", "refseq_ac": [ { "id": "NP_001076880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076880", "type": "external" } ], "gene_names_uniprotkb": "CIAO3; NARFL", "gene_names_refseq": "CIAO3; NARFL", "protein_names_uniprotkb": "Cytosolic iron-sulfur assembly component 3; Cytosolic Fe-S cluster assembly factor NARFL; IOP1; Iron-only hydrogenase-like protein 1; Nuclear prelamin A recognition factor-like protein", "protein_names_refseq": "IOP1; cytosolic Fe-S cluster assembly factor NARFL; cytosolic iron-sulfur assembly component 3; iron-only hydrogenase-like protein 1; nuclear prelamin A recognition factor like; nuclear prelamin A recognition factor-like protein", "tax_id": 9913, "disease": "", "pathway": " (bta:511837)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "36067531", "class_list": "", "function": "Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to negatively regulate the level of HIF1A expression, although this effect could be indirect (By similarity)., [UniProtKB, UniProtKB]; PMM2 and NARFL are paternally imprinted genes in bovines., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding", "go_cellular_component": "GO:0097361 cytosolic [4Fe-4S] assembly targeting complex", "go_biological_process": "GO:0016226 iron-sulfur cluster assembly", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4FV58-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV75-1", "uniprot_id": [ { "id": "TM38A_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV75", "type": "external" } ], "mass": 33314.0, "length": 299, "protein_name": "Trimeric intracellular cation channel type A", "gene_name": "TMEM38A", "organism": "Bovine", "refseq_name": "trimeric intracellular cation channel type A", "refseq_ac": [ { "id": "NP_001076932", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076932", "type": "external" } ], "gene_names_uniprotkb": "TMEM38A", "gene_names_refseq": "TMEM38A", "protein_names_uniprotkb": "Trimeric intracellular cation channel type A; TRIC-A; TRICA; Transmembrane protein 38A", "protein_names_refseq": "TRIC-A; TRICA; trimeric intracellular cation channel type A", "tax_id": 9913, "disease": "", "pathway": " (bta:532775)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Opened by a change of voltage within the sarcoplasmic reticulum lumen., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0005267 potassium channel activity", "go_cellular_component": "GO:0031965 nuclear membrane;GO:0016529 sarcoplasmic reticulum;GO:0033017 sarcoplasmic reticulum membrane", "go_biological_process": "GO:0051279 regulation of release of sequestered calcium ion into cytosol;GO:0071805 potassium ion transmembrane transport;GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV75-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV93-1", "uniprot_id": [ { "id": "DLK2_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV93", "type": "external" } ], "mass": 40507.0, "length": 383, "protein_name": "Protein delta homolog 2", "gene_name": "DLK2", "organism": "Bovine", "refseq_name": "protein delta homolog 2 precursor", "refseq_ac": [ { "id": "NP_001076963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076963", "type": "external" } ], "gene_names_uniprotkb": "DLK2; EGFL9", "gene_names_refseq": "DLK-2; DLK2", "protein_names_uniprotkb": "Protein delta homolog 2; DLK-2; EGF-like protein 9; Epidermal growth factor-like protein 9", "protein_names_refseq": "EGF-like protein 9; EGF-like-domain, multiple 9; epidermal growth factor-like protein 9; protein delta homolog 2 precursor; protein delta homolog 2", "tax_id": 9913, "disease": "", "pathway": " (bta:540262)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates adipogenesis., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0016020 membrane", "go_biological_process": "GO:0045746 negative regulation of Notch signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV93-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4FV97-1", "uniprot_id": [ { "id": "RL1D1_BOVIN", "url": "https://www.uniprot.org/uniprot/A4FV97", "type": "external" } ], "mass": 53076.0, "length": 482, "protein_name": "Ribosomal L1 domain-containing protein 1", "gene_name": "RSL1D1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RSL1D1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ribosomal L1 domain-containing protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates cellular senescence through inhibition of PTEN translation. Acts as a pro-apoptotic regulator in response to DNA damage., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 8, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0048027 mRNA 5'-UTR binding", "go_cellular_component": "GO:0005730 nucleolus", "go_biological_process": "GO:0042981 regulation of apoptotic process;GO:2000772 regulation of cellular senescence", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4FV97-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IF87-1", "uniprot_id": [ { "id": "GNPAT_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IF87", "type": "external" } ], "mass": 77664.0, "length": 680, "protein_name": "Dihydroxyacetone phosphate acyltransferase", "gene_name": "GNPAT", "organism": "Bovine", "refseq_name": "dihydroxyacetone phosphate acyltransferase", "refseq_ac": [ { "id": "NP_001096756", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096756", "type": "external" } ], "gene_names_uniprotkb": "GNPAT", "gene_names_refseq": "GNPAT", "protein_names_uniprotkb": "Dihydroxyacetone phosphate acyltransferase; 2.3.1.42; Glycerone-phosphate O-acyltransferase", "protein_names_refseq": "DAP-AT; DHAP-AT; acyl-CoA:dihydroxyacetonephosphateacyltransferase; dihydroxyacetone phosphate acyltransferase; glycerone-phosphate O-acyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:538800)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dihydroxyacetonephosphate acyltransferase catalyzing the first step in the biosynthesis of plasmalogens, a subset of phospholipids that differ from other glycerolipids by having an alkyl chain attached through a vinyl ether linkage at the sn-1 position of the glycerol backbone, and which unique physical properties have an impact on various aspects of cell signaling and membrane biology., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.42", "type": "external" } ], "go_molecular_function": "GO:0016287 glycerone-phosphate O-acyltransferase activity", "go_cellular_component": "GO:0005778 peroxisomal membrane", "go_biological_process": "GO:0006650 glycerophospholipid metabolic process;GO:0008611 ether lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IF87-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IF89-1", "uniprot_id": [ { "id": "EXOC8_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IF89", "type": "external" } ], "mass": 81840.0, "length": 725, "protein_name": "Exocyst complex component 8", "gene_name": "EXOC8", "organism": "Bovine", "refseq_name": "exocyst complex component 8", "refseq_ac": [ { "id": "NP_001091581", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091581", "type": "external" } ], "gene_names_uniprotkb": "EXOC8", "gene_names_refseq": "EXOC8", "protein_names_uniprotkb": "Exocyst complex component 8", "protein_names_refseq": "exocyst complex 84-kDa subunit; exocyst complex component 8", "tax_id": 9913, "disease": "", "pathway": " (bta:540237); (R-BTA-264876); (R-BTA-5620916)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0030426 growth cone;GO:0048471 perinuclear region of cytoplasm;GO:0005770 late endosome;GO:0000145 exocyst", "go_biological_process": "GO:0015031 protein transport;GO:0022617 extracellular matrix disassembly;GO:0007032 endosome organization;GO:0008104 intracellular protein localization;GO:0006887 exocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IF89-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IF98-1", "uniprot_id": [ { "id": "RMI1_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IF98", "type": "external" } ], "mass": 70051.0, "length": 624, "protein_name": "RecQ-mediated genome instability protein 1", "gene_name": "RMI1", "organism": "Bovine", "refseq_name": "recQ-mediated genome instability protein 1", "refseq_ac": [ { "id": "NP_001077234", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077234", "type": "external" } ], "gene_names_uniprotkb": "RMI1", "gene_names_refseq": "RMI1", "protein_names_uniprotkb": "RecQ-mediated genome instability protein 1", "protein_names_refseq": "recQ-mediated genome instability protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:614063); (R-BTA-5685938); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5693568); (R-BTA-5693579); (R-BTA-5693607); (R-BTA-5693616); (R-BTA-6804756); (R-BTA-69473)", "pathway_count": 10, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000166 nucleotide binding", "go_cellular_component": "GO:0016604 nuclear body;GO:0031422 RecQ family helicase-topoisomerase III complex", "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0006260 DNA replication;GO:0000724 double-strand break repair via homologous recombination;GO:0071139 resolution of DNA recombination intermediates", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IF98-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFB1-1", "uniprot_id": [ { "id": "SRRT_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFB1", "type": "external" } ], "mass": 100566.0, "length": 876, "protein_name": "Serrate RNA effector molecule homolog", "gene_name": "SRRT", "organism": "Bovine", "refseq_name": "serrate RNA effector molecule homolog", "refseq_ac": [ { "id": "NP_001077177", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077177", "type": "external" } ], "gene_names_uniprotkb": "SRRT; ARS2", "gene_names_refseq": "ARS2; SRRT", "protein_names_uniprotkb": "Serrate RNA effector molecule homolog; Arsenite-resistance protein 2", "protein_names_refseq": "arsenate resistance protein 2; arsenite-resistance protein 2; serrate RNA effector molecule homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:527938); (R-BTA-6807505); (R-BTA-72163); (R-BTA-9770562); (R-BTA-9930044)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and DROSHA, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Independently of its activity on miRNAs, necessary and sufficient to promote neural stem cell self-renewal. Does so by directly binding SOX2 promoter and positively regulating its transcription (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 10, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0030674 protein-macromolecule adaptor activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0097150 neuronal stem cell population maintenance;GO:0031053 primary miRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFB1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFC9-1", "uniprot_id": [ { "id": "PTOV1_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFC9", "type": "external" } ], "mass": 46683.0, "length": 415, "protein_name": "Prostate tumor-overexpressed gene 1 protein homolog", "gene_name": "PTOV1", "organism": "Bovine", "refseq_name": "prostate tumor-overexpressed gene 1 protein homolog", "refseq_ac": [ { "id": "NP_001077249", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077249", "type": "external" } ], "gene_names_uniprotkb": "PTOV1", "gene_names_refseq": "PTOV1", "protein_names_uniprotkb": "Prostate tumor-overexpressed gene 1 protein homolog", "protein_names_refseq": "prostate tumor over expressed gene 1; prostate tumor overexpressed 1; prostate tumor-overexpressed gene 1 protein homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:617775)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May activate transcription. Required for nuclear translocation of FLOT1. Promotes cell proliferation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFC9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFD8-1", "uniprot_id": [ { "id": "MET14_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFD8", "type": "external" } ], "mass": 52193.0, "length": 456, "protein_name": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14", "gene_name": "METTL14", "organism": "Bovine", "refseq_name": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14", "refseq_ac": [ { "id": "NP_001077183", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077183", "type": "external" } ], "gene_names_uniprotkb": "METTL14", "gene_names_refseq": "METTL14", "protein_names_uniprotkb": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14; Methyltransferase-like protein 14", "protein_names_refseq": "N(6)-adenosine-methyltransferase non-catalytic subunit METTL14; N6-adenosine-methyltransferase non-catalytic subunit; N6-adenosine-methyltransferase subunit METTL14; methyltransferase like 14; methyltransferase-like protein 14", "tax_id": 9913, "disease": "", "pathway": " (bta:531382)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues at the N(6) position of some mRNAs and regulates the circadian clock, differentiation of embryonic stem cells and cortical neurogenesis. In the heterodimer formed with METTL3, METTL14 constitutes the RNA-binding scaffold that recognizes the substrate rather than the catalytic core. N6-methyladenosine (m6A), which takes place at the 5'-[AG]GAC-3' consensus sites of some mRNAs, plays a role in mRNA stability and processing (By similarity). M6A acts as a key regulator of mRNA stability by promoting mRNA destabilization and degradation (By similarity). In embryonic stem cells (ESCs), m6A methylation of mRNAs encoding key naive pluripotency-promoting transcripts results in transcript destabilization (By similarity). M6A regulates spermatogonial differentiation and meiosis and is essential for male fertility and spermatogenesis (By similarity). M6A also regulates cortical neurogenesis: m6A methylation of transcripts related to transcription factors, neural stem cells, the cell cycle and neuronal differentiation during brain development promotes their destabilization and decay, promoting differentiation of radial glial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003729 mRNA binding", "go_cellular_component": "GO:0036396 RNA N6-methyladenosine methyltransferase complex;GO:0005634 nucleus", "go_biological_process": "GO:0021861 forebrain radial glial cell differentiation;GO:0006397 mRNA processing;GO:0007283 spermatogenesis;GO:0016556 mRNA modification;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFD8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFE9-1", "uniprot_id": [ { "id": "TM9S1_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFE9", "type": "external" } ], "mass": 69162.0, "length": 606, "protein_name": "Transmembrane 9 superfamily member 1", "gene_name": "TM9SF1", "organism": "Bovine", "refseq_name": "transmembrane 9 superfamily member 1 precursor", "refseq_ac": [ { "id": "NP_001077212", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077212", "type": "external" } ], "gene_names_uniprotkb": "TM9SF1", "gene_names_refseq": "TM9SF1", "protein_names_uniprotkb": "Transmembrane 9 superfamily member 1", "protein_names_refseq": "transmembrane 9 superfamily member 1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:539478)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an essential role in autophagy., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000421 autophagosome membrane;GO:0016020 membrane;GO:0005765 lysosomal membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006914 autophagy;GO:0072657 protein localization to membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFE9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFK0-1", "uniprot_id": [ { "id": "PKHO1_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFK0", "type": "external" } ], "mass": 46395.0, "length": 409, "protein_name": "Pleckstrin homology domain-containing family O member 1", "gene_name": "PLEKHO1", "organism": "Bovine", "refseq_name": "pleckstrin homology domain-containing family O member 1", "refseq_ac": [ { "id": "NP_001077266", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077266", "type": "external" } ], "gene_names_uniprotkb": "PLEKHO1", "gene_names_refseq": "PLEKHO1", "protein_names_uniprotkb": "Pleckstrin homology domain-containing family O member 1; PH domain-containing family O member 1", "protein_names_refseq": "PH domain-containing family O member 1; pleckstrin homology domain-containing family O member 1", "tax_id": 9913, "disease": "", "pathway": " (bta:788251)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032587 ruffle membrane;GO:0036195 muscle cell projection membrane", "go_biological_process": "GO:1901739 regulation of myoblast fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFK0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFL1-1", "uniprot_id": [ { "id": "CXA4_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFL1", "type": "external" } ], "mass": 37499.0, "length": 333, "protein_name": "Gap junction alpha-4 protein", "gene_name": "GJA4", "organism": "Bovine", "refseq_name": "gap junction alpha-4 protein", "refseq_ac": [ { "id": "NP_001077207", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077207", "type": "external" } ], "gene_names_uniprotkb": "GJA4", "gene_names_refseq": "GJA4", "protein_names_uniprotkb": "Gap junction alpha-4 protein; Connexin-37; Cx37", "protein_names_refseq": "connexin-37; cx37; gap junction alpha-4 protein; gap junction protein, alpha 4, 37kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:538913); (R-BTA-190861)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "33672423", "class_list": "", "function": "BPA and BPS Affect Connexin 37 in Bovine Cumulus Cells. Publication Status: Online-Only, [RefSeq, PubMed]; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005243 gap junction channel activity", "go_cellular_component": "GO:0005922 connexin complex", "go_biological_process": "GO:0007267 cell-cell signaling", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4IFL1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFM1-1", "uniprot_id": [ { "id": "NALF1_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFM1", "type": "external" } ], "mass": 50897.0, "length": 457, "protein_name": "NALCN channel auxiliary factor 1", "gene_name": "NALF1", "organism": "Bovine", "refseq_name": "NALCN channel auxiliary factor 1", "refseq_ac": [ { "id": "NP_001077245", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077245", "type": "external" } ], "gene_names_uniprotkb": "NALF1; FAM155A", "gene_names_refseq": "FAM155A; NALF1", "protein_names_uniprotkb": "NALCN channel auxiliary factor 1; Transmembrane protein FAM155A", "protein_names_refseq": "NALCN channel auxiliary factor 1; family with sequence similarity 155 member A; transmembrane protein FAM155A", "tax_id": 9913, "disease": "", "pathway": " (bta:616912)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Auxilary subunit component of the NALCN channelosome complex, which regulates the resting membrane potential by depolarizing sodium leak currents (By similarity). The NALCN channelosome complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (By similarity). The NALCN channelosome is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0035725 sodium ion transmembrane transport;GO:0098703 calcium ion import across plasma membrane;GO:0098908 regulation of neuronal action potential", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFM1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFQ0-1", "uniprot_id": [ { "id": "THOC5_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFQ0", "type": "external" } ], "mass": 78530.0, "length": 683, "protein_name": "THO complex subunit 5 homolog", "gene_name": "THOC5", "organism": "Bovine", "refseq_name": "THO complex subunit 5 homolog", "refseq_ac": [ { "id": "NP_001077185", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077185", "type": "external" } ], "gene_names_uniprotkb": "THOC5", "gene_names_refseq": "THOC5", "protein_names_uniprotkb": "THO complex subunit 5 homolog", "protein_names_refseq": "THO complex 5; THO complex subunit 5 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:533001)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes., [UniProtKB, UniProtKB]; Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A5D9B7", "ec_number_list": [], "go_molecular_function": "GO:0003729 mRNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000445 THO complex part of transcription export complex", "go_biological_process": "GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0008380 RNA splicing;GO:0060215 primitive hemopoiesis;GO:0030224 monocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4IFQ0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFR0-1", "uniprot_id": [ { "id": "CXL17_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFR0", "type": "external" } ], "mass": 13597.0, "length": 118, "protein_name": "C-X-C motif chemokine 17", "gene_name": "CXCL17", "organism": "Bovine", "refseq_name": "C-X-C motif chemokine 17 precursor", "refseq_ac": [ { "id": "NP_001077268", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077268", "type": "external" } ], "gene_names_uniprotkb": "CXCL17; VCC1", "gene_names_refseq": "CXCL17", "protein_names_uniprotkb": "C-X-C motif chemokine 17; VEGF coregulated chemokine 1", "protein_names_refseq": "C-X-C motif chemokine 17 precursor; C-X-C motif chemokine 17; VEGF co-regulated chemokine 1; VEGF coregulated chemokine 1; chemokine (C-X-C motif) ligand 17", "tax_id": 9913, "disease": "", "pathway": " (bta:788717)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells, and which is involved in immune regulation and lymphocyte trafficking (By similarity). Activates the C-X-C chemokine receptor GPR25 (By similarity). Plays a key role in lymphocyte homing by activating the receptor GPR25 on lymphocytes, mediating lymphocyte recruitment into the respiratory, upper gastrointestinal, biliary and genito-urinary tracts (By similarity). Plays a role in angiogenesis (By similarity). Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042056 chemoattractant activity;GO:0008009 chemokine activity", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0001525 angiogenesis;GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0030154 cell differentiation;GO:0070098 chemokine-mediated signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A4IFR0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A4IFU8-1", "uniprot_id": [ { "id": "AUNIP_BOVIN", "url": "https://www.uniprot.org/uniprot/A4IFU8", "type": "external" } ], "mass": 39634.0, "length": 357, "protein_name": "Aurora kinase A- and ninein-interacting protein", "gene_name": "AUNIP", "organism": "Bovine", "refseq_name": "aurora kinase A- and ninein-interacting protein", "refseq_ac": [ { "id": "NP_001077211", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077211", "type": "external" } ], "gene_names_uniprotkb": "AUNIP", "gene_names_refseq": "AUNIP; C2H1orf135", "protein_names_uniprotkb": "Aurora kinase A- and ninein-interacting protein", "protein_names_refseq": "aurora A-binding; aurora kinase A- and ninein-interacting protein", "tax_id": 9913, "disease": "", "pathway": " (bta:539251)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0090734 site of DNA damage", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0007051 spindle organization;GO:2001033 negative regulation of double-strand break repair via nonhomologous end joining", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A4IFU8-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D785-1", "uniprot_id": [ { "id": "XPO2_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D785", "type": "external" } ], "mass": 110375.0, "length": 971, "protein_name": "Exportin-2", "gene_name": "CSE1L", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CSE1L; XPO2", "gene_names_refseq": "", "protein_names_uniprotkb": "Exportin-2; Chromosome segregation 1-like protein; Exp2; Importin-alpha re-exporter", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:518622)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0005049 nuclear export signal receptor activity", "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005829 cytosol", "go_biological_process": "GO:0006611 protein export from nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D785-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D789-1", "uniprot_id": [ { "id": "THMS1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D789", "type": "external" } ], "mass": 73132.0, "length": 641, "protein_name": "Protein THEMIS", "gene_name": "THEMIS", "organism": "Bovine", "refseq_name": "protein THEMIS", "refseq_ac": [ { "id": "NP_001091585", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091585", "type": "external" } ], "gene_names_uniprotkb": "THEMIS", "gene_names_refseq": "C9H6ORF190; THEMIS; TSEPA", "protein_names_uniprotkb": "Protein THEMIS; Thymocyte-expressed molecule involved in selection", "protein_names_refseq": "Thymocyte-expressed molecule involved in selection; protein THEMIS; thymocyte selection pathway associated", "tax_id": 9913, "disease": "", "pathway": " (bta:540554)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QQ26", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005911 cell-cell junction;GO:0008180 COP9 signalosome", "go_biological_process": "GO:0043383 negative T cell selection;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0043368 positive T cell selection", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D789-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D791-1", "uniprot_id": [ { "id": "E2AK3_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D791", "type": "external" } ], "mass": 124596.0, "length": 1115, "protein_name": "Eukaryotic translation initiation factor 2-alpha kinase 3", "gene_name": "EIF2AK3", "organism": "Bovine", "refseq_name": "eukaryotic translation initiation factor 2-alpha kinase 3 precursor", "refseq_ac": [ { "id": "NP_001091555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091555", "type": "external" } ], "gene_names_uniprotkb": "EIF2AK3; PERK", "gene_names_refseq": "EIF2AK3", "protein_names_uniprotkb": "Eukaryotic translation initiation factor 2-alpha kinase 3; 2.7.10.2; 2.7.11.1; PRKR-like endoplasmic reticulum kinase; Protein tyrosine kinase EIF2AK3", "protein_names_refseq": "PRKR-like endoplasmic reticulum kinase; eukaryotic translation initiation factor 2-alpha kinase 3 precursor; protein tyrosine kinase EIF2AK3", "tax_id": 9913, "disease": "", "pathway": " (bta:535820); (R-BTA-381042); (R-BTA-9909505)", "pathway_count": 3, "publication_count": 2, "publication_id_list": "19393038;29386355", "class_list": "", "function": "Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to various stress, such as unfolded protein response (UPR) (By similarity). Key effector of the integrated stress response (ISR) to unfolded proteins: EIF2AK3/PERK specifically recognizes and binds misfolded proteins, leading to its activation and EIF2S1/eIF-2-alpha phosphorylation (PubMed:29386355). EIF2S1/eIF-2-alpha phosphorylation in response to stress converts EIF2S1/eIF-2-alpha in a global protein synthesis inhibitor, leading to a global attenuation of cap-dependent translation, while concomitantly initiating the preferential translation of ISR-specific mRNAs, such as the transcriptional activators ATF4 and QRICH1, and hence allowing ATF4- and QRICH1-mediated reprogramming (By similarity). The EIF2AK3/PERK-mediated unfolded protein response increases mitochondrial oxidative phosphorylation by promoting ATF4-mediated expression of COX7A2L/SCAF1, thereby increasing formation of respiratory chain supercomplexes (By similarity). In contrast to most subcellular compartments, mitochondria are protected from the EIF2AK3/PERK-mediated unfolded protein response due to EIF2AK3/PERK inhibition by ATAD3A at mitochondria-endoplasmic reticulum contact sites (By similarity). In addition to EIF2S1/eIF-2-alpha, also phosphorylates NFE2L2/NRF2 in response to stress, promoting release of NFE2L2/NRF2 from the BCR(KEAP1) complex, leading to nuclear accumulation and activation of NFE2L2/NRF2 (By similarity). Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity). Involved in control of mitochondrial morphology and function (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 2, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "F1MCN0", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity;GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site", "go_biological_process": "GO:0070417 cellular response to cold;GO:0001525 angiogenesis;GO:0010575 positive regulation of vascular endothelial growth factor production;GO:0042149 cellular response to glucose starvation;GO:0017148 negative regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A5D791-1", "record_type": "protein", "filter_code": "0000000.0100101.010000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D794-1", "uniprot_id": [ { "id": "GAPD1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D794", "type": "external" } ], "mass": 157375.0, "length": 1413, "protein_name": "GTPase-activating protein and VPS9 domain-containing protein 1", "gene_name": "GAPVD1", "organism": "Bovine", "refseq_name": "GTPase-activating protein and VPS9 domain-containing protein 1", "refseq_ac": [ { "id": "NP_001095990", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095990", "type": "external" } ], "gene_names_uniprotkb": "GAPVD1", "gene_names_refseq": "GAPVD1", "protein_names_uniprotkb": "GTPase-activating protein and VPS9 domain-containing protein 1", "protein_names_refseq": "GTPase-activating protein and VPS9 domain-containing protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:539646); (R-BTA-8856828); (R-BTA-8876198)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 21, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0032794 GTPase activating protein binding", "go_cellular_component": "GO:0005768 endosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0051223 regulation of protein transport;GO:0006897 endocytosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D794-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D796-1", "uniprot_id": [ { "id": "SPE39_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D796", "type": "external" } ], "mass": 55615.0, "length": 481, "protein_name": "Spermatogenesis-defective protein 39 homolog", "gene_name": "VIPAS39", "organism": "Bovine", "refseq_name": "spermatogenesis-defective protein 39 homolog", "refseq_ac": [ { "id": "NP_001091469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091469", "type": "external" } ], "gene_names_uniprotkb": "VIPAS39; SPE39; VIPAR", "gene_names_refseq": "C10H14orf133; SPE-39; SPE39; VIPAR; VIPAS39", "protein_names_uniprotkb": "Spermatogenesis-defective protein 39 homolog; SPE-39; VPS33B-interacting protein in apical-basolateral polarity regulator; VPS33B-interacting protein in polarity and apical restriction", "protein_names_refseq": "VPS33B-interacting protein in apical-basolateral polarity regulator; VPS33B-interacting protein in polarity and apical restriction; spermatogenesis-defective protein 39 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:508872)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0055037 recycling endosome;GO:0005770 late endosome;GO:0099023 vesicle tethering complex", "go_biological_process": "GO:0007034 vacuolar transport;GO:0006351 DNA-templated transcription;GO:0006886 intracellular protein transport;GO:0007283 spermatogenesis;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D796-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7A0-1", "uniprot_id": [ { "id": "EFHD2_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7A0", "type": "external" } ], "mass": 26918.0, "length": 242, "protein_name": "EF-hand domain-containing protein D2", "gene_name": "EFHD2", "organism": "Bovine", "refseq_name": "EF-hand domain-containing protein D2", "refseq_ac": [ { "id": "NP_001096715", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096715", "type": "external" } ], "gene_names_uniprotkb": "EFHD2; SWS1", "gene_names_refseq": "EFHD2", "protein_names_uniprotkb": "EF-hand domain-containing protein D2; Swiprosin-1", "protein_names_refseq": "EF-hand domain-containing protein D2; swiprosin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:514259)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May regulate B-cell receptor (BCR)-induced immature and primary B-cell apoptosis. Plays a role as negative regulator of the canonical NF-kappa-B-activating branch. Controls spontaneous apoptosis through the regulation of BCL2L1 abundance., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0045121 membrane raft", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7A0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7B1-1", "uniprot_id": [ { "id": "RSAD1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7B1", "type": "external" } ], "mass": 48722.0, "length": 442, "protein_name": "Radical S-adenosyl methionine domain-containing protein 1, mitochondrial", "gene_name": "RSAD1", "organism": "Bovine", "refseq_name": "radical S-adenosyl methionine domain-containing protein 1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001091605", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091605", "type": "external" } ], "gene_names_uniprotkb": "RSAD1", "gene_names_refseq": "RSAD1", "protein_names_uniprotkb": "Radical S-adenosyl methionine domain-containing protein 1, mitochondrial; Putative heme chaperone", "protein_names_refseq": "oxygen-independent coproporphyrinogen-III oxidase-like protein RSAD1; putative heme chaperone; radical S-adenosyl methionine domain-containing protein 1, mitochondrial precursor; radical S-adenosyl methionine domain-containing protein 1, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:615755)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity (By similarity). Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0004109 coproporphyrinogen oxidase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0006779 porphyrin-containing compound biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7B1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7N9-1", "uniprot_id": [ { "id": "MS18A_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7N9", "type": "external" } ], "mass": 26318.0, "length": 235, "protein_name": "Protein Mis18-alpha", "gene_name": "MIS18A", "organism": "Bovine", "refseq_name": "protein Mis18-alpha", "refseq_ac": [ { "id": "NP_001091479", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091479", "type": "external" } ], "gene_names_uniprotkb": "MIS18A", "gene_names_refseq": "MIS18A", "protein_names_uniprotkb": "Protein Mis18-alpha", "protein_names_refseq": "MIS18 kinetochore protein homolog A; protein Mis18-alpha", "tax_id": 9913, "disease": "", "pathway": " (bta:510809); (R-BTA-606279)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0042802 identical protein binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005634 nucleus;GO:0000775 chromosome, centromeric region;GO:0000785 chromatin;GO:0098654 CENP-A recruiting complex", "go_biological_process": "GO:0051301 cell division;GO:0034080 CENP-A containing chromatin assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7N9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7P8-1", "uniprot_id": [ { "id": "SOSB2_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7P8", "type": "external" } ], "mass": 22449.0, "length": 206, "protein_name": "SOSS complex subunit B2", "gene_name": "NABP1", "organism": "Bovine", "refseq_name": "SOSS complex subunit B2", "refseq_ac": [ { "id": "NP_001091593", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091593", "type": "external" } ], "gene_names_uniprotkb": "NABP1; OBFC2A; SSB2", "gene_names_refseq": "NABP1; OBFC2A", "protein_names_uniprotkb": "SOSS complex subunit B2; Nucleic acid-binding protein 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; SOSS-B2; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; Single-stranded DNA-binding protein 2", "protein_names_refseq": "SOSS complex subunit B2; SOSS-B2; oligonucleotide/oligosaccharide-binding fold containing 2A; oligonucleotide/oligosaccharide-binding fold-containing protein 2A; sensor of single-strand DNA complex subunit B2; sensor of ssDNA subunit B2; single-stranded DNA-binding protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:613474); (R-BTA-6807505)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005694 chromosome;GO:0070876 SOSS complex;GO:0005634 nucleus", "go_biological_process": "GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination;GO:0044818 mitotic G2/M transition checkpoint;GO:0006281 DNA repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7P8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7R1-1", "uniprot_id": [ { "id": "TR11B_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7R1", "type": "external" } ], "mass": 46418.0, "length": 402, "protein_name": "Tumor necrosis factor receptor superfamily member 11B", "gene_name": "TNFRSF11B", "organism": "Bovine", "refseq_name": "tumor necrosis factor receptor superfamily member 11B precursor", "refseq_ac": [ { "id": "NP_001091525", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091525", "type": "external" } ], "gene_names_uniprotkb": "TNFRSF11B", "gene_names_refseq": "TNFRSF11B", "protein_names_uniprotkb": "Tumor necrosis factor receptor superfamily member 11B; Osteoprotegerin", "protein_names_refseq": "osteoprotegerin; tumor necrosis factor receptor superfamily member 11B precursor; tumor necrosis factor receptor superfamily member 11B; tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)", "tax_id": 9913, "disease": "", "pathway": " (bta:523822); (R-BTA-5669034)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1904399 heparan sulfate binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007165 signal transduction;GO:0006915 apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7R1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7T4-1", "uniprot_id": [ { "id": "SIAT2_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7T4", "type": "external" } ], "mass": 55418.0, "length": 495, "protein_name": "Beta-galactoside alpha-2,6-sialyltransferase 2", "gene_name": "ST6GAL2", "organism": "Bovine", "refseq_name": "beta-galactoside alpha-2,6-sialyltransferase 2", "refseq_ac": [ { "id": "NP_001008668", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008668", "type": "external" } ], "gene_names_uniprotkb": "ST6GAL2", "gene_names_refseq": "SIAT2; ST6GAL2; ST6Gal II; ST6GalII", "protein_names_uniprotkb": "Beta-galactoside alpha-2,6-sialyltransferase 2; 2.4.3.1; Alpha 2,6-ST 2; CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 2; ST6Gal II; ST6GalII; Sialyltransferase 2", "protein_names_refseq": "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase 2; ST6Gal-II; alpha 2,6 sialyltransferase; alpha 2,6-ST 2; alpha-2,6-sialyltransferase ST6Gal II; beta-galactoside alpha-2,6-sialyltransferase 2; sialyltransferase 2 (monosialoganglioside sialyltransferase)", "tax_id": 9913, "disease": "", "pathway": " (bta:493992); (R-BTA-4085001)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "15843597", "class_list": "glycogene;glycosyltransferase", "function": "Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q2I130;Q5QQ36", "ec_number_list": [ { "id": "2.4.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.3.1", "type": "external" } ], "go_molecular_function": "GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0032580 Golgi cisterna membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0097503 sialylation", "synthesized_glycan_count": 1722, "hit_score": 0.2, "record_id": "A5D7T4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7U1-1", "uniprot_id": [ { "id": "PLET1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7U1", "type": "external" } ], "mass": 26609.0, "length": 242, "protein_name": "Placenta-expressed transcript 1 protein", "gene_name": "PLET1", "organism": "Bovine", "refseq_name": "placenta-expressed transcript 1 protein precursor", "refseq_ac": [ { "id": "NP_001107010", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107010", "type": "external" } ], "gene_names_uniprotkb": "PLET1", "gene_names_refseq": "C15H11orf34; PLET1", "protein_names_uniprotkb": "Placenta-expressed transcript 1 protein", "protein_names_refseq": "placenta-expressed transcript 1 protein precursor; placenta-expressed transcript 1 protein", "tax_id": 9913, "disease": "", "pathway": " (bta:505518)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle (By similarity)., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration;GO:0001953 negative regulation of cell-matrix adhesion;GO:0035313 wound healing, spreading of epidermal cells", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7U1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D7V9-1", "uniprot_id": [ { "id": "SYHM_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D7V9", "type": "external" } ], "mass": 56914.0, "length": 506, "protein_name": "Histidine--tRNA ligase, mitochondrial", "gene_name": "HARS2", "organism": "Bovine", "refseq_name": "histidine--tRNA ligase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001091602", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091602", "type": "external" } ], "gene_names_uniprotkb": "HARS2", "gene_names_refseq": "HARS2", "protein_names_uniprotkb": "Histidine--tRNA ligase, mitochondrial; 6.1.1.21; HisRS; Histidyl-tRNA synthetase", "protein_names_refseq": "Probable histidyl-tRNA synthetase, mitochondrial; hisRS; histidine--tRNA ligase, mitochondrial precursor; histidyl-tRNA synthetase 2, mitochondrial (putative); probable histidine--tRNA ligase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:615182)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.21", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0004821 histidine-tRNA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0006427 histidyl-tRNA aminoacylation;GO:0032543 mitochondrial translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5D7V9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5D992-1", "uniprot_id": [ { "id": "SPY1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5D992", "type": "external" } ], "mass": 34959.0, "length": 319, "protein_name": "Protein sprouty homolog 1", "gene_name": "SPRY1", "organism": "Bovine", "refseq_name": "protein sprouty homolog 1", "refseq_ac": [ { "id": "NP_001092836", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092836", "type": "external" } ], "gene_names_uniprotkb": "SPRY1", "gene_names_refseq": "SPRY1", "protein_names_uniprotkb": "Protein sprouty homolog 1; Spry-1", "protein_names_refseq": "protein sprouty homolog 1; sprouty homolog 1, antagonist of FGF signaling; spry-1", "tax_id": 9913, "disease": "", "pathway": " (bta:507095)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0070373 negative regulation of ERK1 and ERK2 cascade;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway;GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5D992-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJ93-1", "uniprot_id": [ { "id": "MZB1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJ93", "type": "external" } ], "mass": 20699.0, "length": 189, "protein_name": "Marginal zone B- and B1-cell-specific protein", "gene_name": "MZB1", "organism": "Bovine", "refseq_name": "marginal zone B- and B1-cell-specific protein precursor", "refseq_ac": [ { "id": "NP_001092400", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092400", "type": "external" } ], "gene_names_uniprotkb": "MZB1; PACAP", "gene_names_refseq": "MZB1; PACAP; pERp1", "protein_names_uniprotkb": "Marginal zone B- and B1-cell-specific protein; Plasma cell-induced resident ER protein; Plasma cell-induced resident endoplasmic reticulum protein; Proapoptotic caspase adapter protein; pERp1", "protein_names_refseq": "Proapoptotic caspase adapter protein; marginal zone B- and B1-cell-specific protein precursor; plasma cell-induced ER protein 1; plasma cell-induced resident ER protein; plasma cell-induced resident endoplasmic reticulum protein", "tax_id": 9913, "disease": "", "pathway": " (bta:510480)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance (By similarity)., [UniProtKB]; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion, and integrin activation (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005576 extracellular region;GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation;GO:0030888 regulation of B cell proliferation;GO:0033622 integrin activation;GO:0046626 regulation of insulin receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJ93-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJA8-1", "uniprot_id": [ { "id": "EMC7_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJA8", "type": "external" } ], "mass": 26560.0, "length": 241, "protein_name": "Endoplasmic reticulum membrane protein complex subunit 7", "gene_name": "EMC7", "organism": "Bovine", "refseq_name": "endoplasmic reticulum membrane protein complex subunit 7 precursor", "refseq_ac": [ { "id": "NP_001092613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092613", "type": "external" } ], "gene_names_uniprotkb": "EMC7", "gene_names_refseq": "C10H15orf24; EMC7", "protein_names_uniprotkb": "Endoplasmic reticulum membrane protein complex subunit 7; ER membrane protein complex subunit 7", "protein_names_refseq": "UPF0480 protein C15orf24 homolog; endoplasmic reticulum membrane protein complex subunit 7 precursor; endoplasmic reticulum membrane protein complex subunit 7", "tax_id": 9913, "disease": "", "pathway": " (bta:615423)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030246 carbohydrate binding", "go_cellular_component": "GO:0072546 EMC complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJA8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJD0-1", "uniprot_id": [ { "id": "URAD_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJD0", "type": "external" } ], "mass": 18942.0, "length": 170, "protein_name": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase", "gene_name": "URAD", "organism": "Bovine", "refseq_name": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase", "refseq_ac": [ { "id": "NP_001093173", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093173", "type": "external" } ], "gene_names_uniprotkb": "URAD; PRHOXNB", "gene_names_refseq": "PRHOXNB; URAD", "protein_names_uniprotkb": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; 4.1.1.97; OHCU decarboxylase; Parahox neighbor; Ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase", "protein_names_refseq": "2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; parahox cluster neighbor; parahox neighbor", "tax_id": 9913, "disease": "", "pathway": " (bta:518364)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin, a step in the uric acid degradation pathway following urate oxidation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.97", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.97", "type": "external" } ], "go_molecular_function": "GO:0051997 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase activity", "go_cellular_component": "GO:0005777 peroxisome", "go_biological_process": "GO:0019628 urate catabolic process;GO:0006144 purine nucleobase metabolic process;GO:0000255 allantoin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJD0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJI5-1", "uniprot_id": [ { "id": "GET3_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJI5", "type": "external" } ], "mass": 38793.0, "length": 348, "protein_name": "ATPase GET3", "gene_name": "GET3", "organism": "Bovine", "refseq_name": "ATPase GET3", "refseq_ac": [ { "id": "NP_001092334", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092334", "type": "external" } ], "gene_names_uniprotkb": "GET3; ASNA1", "gene_names_refseq": "GET3", "protein_names_uniprotkb": "ATPase GET3; 3.6.4.-; Arsenical pump-driving ATPase; Arsenite-stimulated ATPase; Guided entry of tail-anchored proteins factor 3, ATPase", "protein_names_refseq": "ATPase ASNA1; ATPase GET3; Arsenical resistance ATPase; Arsenite-translocating ATPase; Arsenite-transporting ATPase; arsA arsenite transporter, ATP-binding, homolog 1; arsenical pump-driving ATPase; arsenite-stimulated ATPase", "tax_id": 9913, "disease": "", "pathway": " (bta:504586)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016887 ATP hydrolysis activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0043529 GET complex", "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJI5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJI7-1", "uniprot_id": [ { "id": "EI2BG_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJI7", "type": "external" } ], "mass": 50218.0, "length": 452, "protein_name": "Translation initiation factor eIF2B subunit gamma", "gene_name": "EIF2B3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EIF2B3", "gene_names_refseq": "", "protein_names_uniprotkb": "Translation initiation factor eIF2B subunit gamma; eIF2B GDP-GTP exchange factor subunit gamma", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0003743 translation initiation factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005851 eukaryotic translation initiation factor 2B complex", "go_biological_process": "GO:0002183 cytoplasmic translational initiation;GO:0050852 T cell receptor signaling pathway;GO:0006413 translational initiation;GO:0014003 oligodendrocyte development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJI7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJM5-1", "uniprot_id": [ { "id": "MCMBP_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJM5", "type": "external" } ], "mass": 73096.0, "length": 642, "protein_name": "Mini-chromosome maintenance complex-binding protein", "gene_name": "MCMBP", "organism": "Bovine", "refseq_name": "mini-chromosome maintenance complex-binding protein", "refseq_ac": [ { "id": "NP_001092444", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092444", "type": "external" } ], "gene_names_uniprotkb": "MCMBP", "gene_names_refseq": "C26H10ORF119; MCM-BP; MCMBP", "protein_names_uniprotkb": "Mini-chromosome maintenance complex-binding protein; MCM-BP; MCM-binding protein", "protein_names_refseq": "MCM-binding protein; mini-chromosome maintenance complex-binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:514863)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0051301 cell division;GO:0007062 sister chromatid cohesion;GO:0006261 DNA-templated DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJM5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJN8-1", "uniprot_id": [ { "id": "SF3A2_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJN8", "type": "external" } ], "mass": 50612.0, "length": 477, "protein_name": "Splicing factor 3A subunit 2", "gene_name": "SF3A2", "organism": "Bovine", "refseq_name": "splicing factor 3A subunit 2", "refseq_ac": [ { "id": "NP_001092681", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092681", "type": "external" } ], "gene_names_uniprotkb": "SF3A2", "gene_names_refseq": "SF3A2", "protein_names_uniprotkb": "Splicing factor 3A subunit 2", "protein_names_refseq": "splicing factor 3A subunit 2; splicing factor 3a, subunit 2, 66kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:789082); (R-BTA-72163); (R-BTA-9770562); (R-BTA-9943411)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005634 nucleus;GO:0071013 catalytic step 2 spliceosome;GO:0005686 U2 snRNP;GO:0071004 U2-type prespliceosome;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0000245 spliceosomal complex assembly;GO:1903241 U2-type prespliceosome assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJN8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJP1-1", "uniprot_id": [ { "id": "BL1S3_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJP1", "type": "external" } ], "mass": 21058.0, "length": 200, "protein_name": "Biogenesis of lysosome-related organelles complex 1 subunit 3", "gene_name": "BLOC1S3", "organism": "Bovine", "refseq_name": "biogenesis of lysosome-related organelles complex 1 subunit 3", "refseq_ac": [ { "id": "XP_059733058", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059733058", "type": "external" } ], "gene_names_uniprotkb": "BLOC1S3", "gene_names_refseq": "BLOC1S3", "protein_names_uniprotkb": "Biogenesis of lysosome-related organelles complex 1 subunit 3; BLOC-1 subunit 3", "protein_names_refseq": "biogenesis of lysosome-related organelles complex 1 subunit 3", "tax_id": 9913, "disease": "", "pathway": " (bta:132342079); (bta:538539); (R-BTA-432722)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008320 protein transmembrane transporter activity", "go_cellular_component": "GO:0005829 cytosol;GO:0030133 transport vesicle;GO:1904115 axon cytoplasm;GO:0031083 BLOC-1 complex", "go_biological_process": "GO:0031175 neuron projection development;GO:0030168 platelet activation;GO:0008089 anterograde axonal transport;GO:0035646 endosome to melanosome transport;GO:0048490 anterograde synaptic vesicle transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJP1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJS2-1", "uniprot_id": [ { "id": "S5A1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJS2", "type": "external" } ], "mass": 29186.0, "length": 257, "protein_name": "3-oxo-5-alpha-steroid 4-dehydrogenase 1", "gene_name": "SRD5A1", "organism": "Bovine", "refseq_name": "3-oxo-5-alpha-steroid 4-dehydrogenase 1", "refseq_ac": [ { "id": "NP_001092607", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092607", "type": "external" } ], "gene_names_uniprotkb": "SRD5A1", "gene_names_refseq": "S5AR 1; SRD5A1", "protein_names_uniprotkb": "3-oxo-5-alpha-steroid 4-dehydrogenase 1; 1.3.1.22; S5AR 1; SR type 1; Steroid 5-alpha-reductase 1", "protein_names_refseq": "3-oxo-5-alpha-steroid 4-dehydrogenase 1; SR type 1", "tax_id": 9913, "disease": "", "pathway": " (bta:614612); (R-BTA-193048)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms. Converts testosterone into 5-alpha-dihydrotestosterone (DHT), a more potent androgen as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual differentiation during development. Besides testosterone, it can also act on other steroids, including progesterone, androstenedione, and corticoids, producing metabolites with diverse roles. Hence, it plays a central role in sexual differentiation and androgen physiology., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.3.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.22", "type": "external" }, { "id": "1.3.1.94", "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.94", "type": "external" } ], "go_molecular_function": "GO:0003865 3-oxo-5-alpha-steroid 4-dehydrogenase activity;GO:0047751 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) activity", "go_cellular_component": "GO:0043025 neuronal cell body;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0008584 male gonad development;GO:0006702 androgen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJS2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJU7-1", "uniprot_id": [ { "id": "RMI2_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJU7", "type": "external" } ], "mass": 16948.0, "length": 157, "protein_name": "RecQ-mediated genome instability protein 2", "gene_name": "RMI2", "organism": "Bovine", "refseq_name": "recQ-mediated genome instability protein 2", "refseq_ac": [ { "id": "NP_001093190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093190", "type": "external" } ], "gene_names_uniprotkb": "RMI2", "gene_names_refseq": "C25H16orf75; RMI2", "protein_names_uniprotkb": "RecQ-mediated genome instability protein 2", "protein_names_refseq": "RMI2, RecQ mediated genome instability 2, homolog; recQ-mediated genome instability protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:615553)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005829 cytosol;GO:0016607 nuclear speck", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0033045 regulation of sister chromatid segregation;GO:0043007 maintenance of rDNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJU7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PJV3-1", "uniprot_id": [ { "id": "HUTI_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PJV3", "type": "external" } ], "mass": 46749.0, "length": 426, "protein_name": "Probable imidazolonepropionase", "gene_name": "AMDHD1", "organism": "Bovine", "refseq_name": "probable imidazolonepropionase", "refseq_ac": [ { "id": "NP_001092342", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092342", "type": "external" } ], "gene_names_uniprotkb": "AMDHD1", "gene_names_refseq": "AMDHD1", "protein_names_uniprotkb": "Probable imidazolonepropionase; 3.5.2.7; Amidohydrolase domain-containing protein 1", "protein_names_refseq": "amidohydrolase domain-containing protein 1; probable imidazolonepropionase", "tax_id": 9913, "disease": "", "pathway": " (bta:505315); (R-BTA-70921)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to form N-formimidoyl-L-glutamate. This reaction represents the third step of the universal histidine degradation pathway. In addition to its metabolic role, functions as a tumor suppressor by promoting TGF-beta signaling. Mechanistically, inhibits ubiquitination and proteasomal degradation of SMAD4, thereby stabilizing the protein. Enhances SMAD2/3 phosphorylation and increases TGF-beta-dependent transcriptional responses. Consequently, promotes apoptosis and induces cell cycle arrest in tumor cells., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.2.7", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.7", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0050480 imidazolonepropionase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0019557 L-histidine catabolic process to glutamate and formate;GO:0006548 L-histidine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PJV3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK00-1", "uniprot_id": [ { "id": "VPS36_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK00", "type": "external" } ], "mass": 43791.0, "length": 386, "protein_name": "Vacuolar protein-sorting-associated protein 36", "gene_name": "VPS36", "organism": "Bovine", "refseq_name": "vacuolar protein-sorting-associated protein 36", "refseq_ac": [ { "id": "NP_001092409", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092409", "type": "external" } ], "gene_names_uniprotkb": "VPS36", "gene_names_refseq": "VPS36", "protein_names_uniprotkb": "Vacuolar protein-sorting-associated protein 36; ESCRT-II complex subunit VPS36", "protein_names_refseq": "ESCRT-II complex subunit VPS36; vacuolar protein-sorting-associated protein 36", "tax_id": 9913, "disease": "", "pathway": " (bta:511223)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0043130 ubiquitin binding", "go_cellular_component": "GO:0000814 ESCRT II complex;GO:0005634 nucleus;GO:0005768 endosome;GO:0031902 late endosome membrane", "go_biological_process": "GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PK00-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK19-1", "uniprot_id": [ { "id": "EFNMT_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK19", "type": "external" } ], "mass": 78751.0, "length": 699, "protein_name": "eEF1A lysine and N-terminal methyltransferase", "gene_name": "METTL13", "organism": "Bovine", "refseq_name": "eEF1A lysine and N-terminal methyltransferase", "refseq_ac": [ { "id": "NP_001092555", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092555", "type": "external" } ], "gene_names_uniprotkb": "METTL13; EEF1AKNMT; FEAT", "gene_names_refseq": "EEF1AKNMT; METTL13", "protein_names_uniprotkb": "eEF1A lysine and N-terminal methyltransferase; Methyltransferase-like protein 13; eEF1A-KNMT", "protein_names_refseq": "eEF1A lysine and N-terminal methyltransferase; eEF1A-KNMT; methyltransferase like 13; methyltransferase-like protein 13", "tax_id": 9913, "disease": "", "pathway": " (bta:538472)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dual methyltransferase that catalyzes methylation of elongation factor 1-alpha (EEF1A1 and EEF1A2) at two different positions, and is therefore involved in the regulation of mRNA translation (By similarity). Via its C-terminus, methylates EEF1A1 and EEF1A2 at the N-terminal residue 'Gly-2' (By similarity). Via its N-terminus dimethylates EEF1A1 and EEF1A2 at residue 'Lys-55' (By similarity). Has no activity towards core histones H2A, H2B, H3 and H4 (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.4.24.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.71", "type": "external" } ], "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PK19-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK21-1", "uniprot_id": [ { "id": "CKP2L_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK21", "type": "external" } ], "mass": 82608.0, "length": 744, "protein_name": "Cytoskeleton-associated protein 2-like", "gene_name": "CKAP2L", "organism": "Bovine", "refseq_name": "cytoskeleton-associated protein 2-like", "refseq_ac": [ { "id": "NP_001092371", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092371", "type": "external" } ], "gene_names_uniprotkb": "CKAP2L", "gene_names_refseq": "CKAP2L", "protein_names_uniprotkb": "Cytoskeleton-associated protein 2-like; Radial fiber and mitotic spindle protein; Radmis", "protein_names_refseq": "cytoskeleton-associated protein 2-like; radial fiber and mitotic spindle protein; radmis", "tax_id": 9913, "disease": "", "pathway": " (bta:507498)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8I3", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005829 cytosol;GO:0072686 mitotic spindle", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A5PK21-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK23-1", "uniprot_id": [ { "id": "MED26_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK23", "type": "external" } ], "mass": 65515.0, "length": 599, "protein_name": "Mediator of RNA polymerase II transcription subunit 26", "gene_name": "MED26", "organism": "Bovine", "refseq_name": "mediator of RNA polymerase II transcription subunit 26", "refseq_ac": [ { "id": "NP_001092358", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092358", "type": "external" } ], "gene_names_uniprotkb": "MED26; CRSP7", "gene_names_refseq": "MED26", "protein_names_uniprotkb": "Mediator of RNA polymerase II transcription subunit 26; CRSP complex subunit 7; Cofactor required for Sp1 transcriptional activation subunit 7; Mediator complex subunit 26", "protein_names_refseq": "CRSP complex subunit 7; cofactor required for Sp1 transcriptional activation subunit 7; mediator of RNA polymerase II transcription subunit 26", "tax_id": 9913, "disease": "", "pathway": " (bta:506331)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003712 transcription coregulator activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016592 mediator complex;GO:0070847 core mediator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PK23-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK26-1", "uniprot_id": [ { "id": "ACAP1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK26", "type": "external" } ], "mass": 82129.0, "length": 745, "protein_name": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1", "gene_name": "ACAP1", "organism": "Bovine", "refseq_name": "arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1", "refseq_ac": [ { "id": "NP_001096704", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096704", "type": "external" } ], "gene_names_uniprotkb": "ACAP1; CENTB1", "gene_names_refseq": "ACAP1; CENTB1", "protein_names_uniprotkb": "Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; Centaurin-beta-1; Cnt-b1", "protein_names_refseq": "arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1; centaurin, beta 1; cnt-b1", "tax_id": 9913, "disease": "", "pathway": " (bta:508582)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0055038 recycling endosome membrane", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PK26-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK43-1", "uniprot_id": [ { "id": "ERAL1_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK43", "type": "external" } ], "mass": 48567.0, "length": 437, "protein_name": "GTPase Era, mitochondrial", "gene_name": "ERAL1", "organism": "Bovine", "refseq_name": "GTPase Era, mitochondrial", "refseq_ac": [ { "id": "NP_001092492", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092492", "type": "external" } ], "gene_names_uniprotkb": "ERAL1", "gene_names_refseq": "ERAL1", "protein_names_uniprotkb": "GTPase Era, mitochondrial; ERA-like protein 1", "protein_names_refseq": "ERA-like protein 1; Era G-protein-like 1; Era-like 1; GTPase Era, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:523344); (R-BTA-5389840); (R-BTA-5419276); (R-BTA-9937383)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probable GTPase that plays a role in the mitochondrial ribosomal small subunit assembly. Specifically binds the 12S mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating the 3' terminal stem-loop region. May act as a chaperone that protects the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small subunit assembly (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005525 GTP binding;GO:0043024 ribosomal small subunit binding;GO:0019843 rRNA binding", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0000028 ribosomal small subunit assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PK43-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK45-1", "uniprot_id": [ { "id": "GT251_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK45", "type": "external" } ], "mass": 71547.0, "length": 623, "protein_name": "Procollagen galactosyltransferase 1", "gene_name": "COLGALT1", "organism": "Bovine", "refseq_name": "procollagen galactosyltransferase 1 precursor", "refseq_ac": [ { "id": "NP_001092425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092425", "type": "external" } ], "gene_names_uniprotkb": "COLGALT1; GLT25D1", "gene_names_refseq": "COLGALT1; GLT25D1", "protein_names_uniprotkb": "Procollagen galactosyltransferase 1; 2.4.1.50; Collagen beta(1-O)galactosyltransferase 1; Glycosyltransferase 25 family member 1; Hydroxylysine galactosyltransferase 1", "protein_names_refseq": "glycosyltransferase 25 domain containing 1; glycosyltransferase 25 family member 1; hydroxylysine galactosyltransferase 1; procollagen galactosyltransferase 1 precursor; procollagen galactosyltransferase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:513167); (R-BTA-1650814)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "glycogene;glycosyltransferase", "function": "Beta-galactosyltransferase that transfers beta-galactose to hydroxylysine residues of type I collagen. By acting on collagen glycosylation, facilitates the formation of collagen triple helix. Also involved in the biosynthesis of collagen type IV., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.50", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.50", "type": "external" } ], "go_molecular_function": "GO:0050211 procollagen galactosyltransferase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen", "go_biological_process": "GO:1904028 positive regulation of collagen fibril organization;GO:0180062 protein O-linked glycosylation via galactose", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PK45-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK51-1", "uniprot_id": [ { "id": "PNCB_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK51", "type": "external" } ], "mass": 57871.0, "length": 538, "protein_name": "Nicotinate phosphoribosyltransferase", "gene_name": "NAPRT", "organism": "Bovine", "refseq_name": "nicotinate phosphoribosyltransferase", "refseq_ac": [ { "id": "NP_001092327", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092327", "type": "external" } ], "gene_names_uniprotkb": "NAPRT; NAPRT1", "gene_names_refseq": "NAPRT1; NAPRT", "protein_names_uniprotkb": "Nicotinate phosphoribosyltransferase; 6.3.4.21; NAPRTase; Nicotinate phosphoribosyltransferase domain-containing protein 1", "protein_names_refseq": "NAPRTase; nicotinate phosphoribosyltransferase domain containing 1; nicotinate phosphoribosyltransferase domain-containing protein 1; nicotinate phosphoribosyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:399559)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q6XQN3", "ec_number_list": [ { "id": "6.3.4.21", "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.4.21", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016740 transferase activity;GO:0004516 nicotinate phosphoribosyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0034355 NAD+ biosynthetic process via the salvage pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PK51-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK63-1", "uniprot_id": [ { "id": "RS17_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK63", "type": "external" } ], "mass": 15582.0, "length": 135, "protein_name": "Small ribosomal subunit protein eS17", "gene_name": "RPS17", "organism": "Bovine", "refseq_name": "small ribosomal subunit protein eS17", "refseq_ac": [ { "id": "NP_001092680", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092680", "type": "external" } ], "gene_names_uniprotkb": "RPS17", "gene_names_refseq": "RPS17", "protein_names_uniprotkb": "Small ribosomal subunit protein eS17; 40S ribosomal protein S17", "protein_names_refseq": "40S ribosomal protein S17; small ribosomal subunit protein eS17", "tax_id": 9913, "disease": "", "pathway": " (bta:788861)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A6QLM6", "ec_number_list": [], "go_molecular_function": "GO:0003735 structural constituent of ribosome", "go_cellular_component": "GO:0032040 small-subunit processome;GO:0022627 cytosolic small ribosomal subunit", "go_biological_process": "GO:0006412 translation;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PK63-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PK65-1", "uniprot_id": [ { "id": "DOPD_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PK65", "type": "external" } ], "mass": 12877.0, "length": 118, "protein_name": "D-dopachrome decarboxylase", "gene_name": "DDT", "organism": "Bovine", "refseq_name": "D-dopachrome decarboxylase", "refseq_ac": [ { "id": "NP_001092620", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092620", "type": "external" } ], "gene_names_uniprotkb": "DDT", "gene_names_refseq": "DDT", "protein_names_uniprotkb": "D-dopachrome decarboxylase; 4.1.1.84; D-dopachrome tautomerase", "protein_names_refseq": "D-dopachrome decarboxylase", "tax_id": 9913, "disease": "", "pathway": " (bta:615999)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tautomerization of D-dopachrome with decarboxylation to give 5,6-dihydroxyindole (DHI)., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.1.84", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.84", "type": "external" } ], "go_molecular_function": "GO:0033981 D-dopachrome decarboxylase activity;GO:0050178 phenylpyruvate tautomerase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0042438 melanin biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PK65-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PKD9-1", "uniprot_id": [ { "id": "AB17C_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PKD9", "type": "external" } ], "mass": 35864.0, "length": 329, "protein_name": "Alpha/beta hydrolase domain-containing protein 17C", "gene_name": "ABHD17C", "organism": "Bovine", "refseq_name": "alpha/beta hydrolase domain-containing protein 17C", "refseq_ac": [ { "id": "NP_001092484", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092484", "type": "external" } ], "gene_names_uniprotkb": "ABHD17C", "gene_names_refseq": "ABHD17C; FAM108C1", "protein_names_uniprotkb": "Alpha/beta hydrolase domain-containing protein 17C; 3.1.2.22; Abhydrolase domain-containing protein 17C", "protein_names_refseq": "abhydrolase domain-containing protein 17C; abhydrolase domain-containing protein FAM108C1; alpha/beta hydrolase domain-containing protein 17C; family with sequence similarity 108, member C1; protein ABHD17C", "tax_id": 9913, "disease": "", "pathway": " (bta:520956); (R-BTA-9648002)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes fatty acids from S-acylated cysteine residues in proteins. Has depalmitoylating activity towards NRAS and DLG4/PSD95., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.2.22", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22", "type": "external" }, { "id": "3.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2", "type": "external" }, { "id": "3.1.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "3.1.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-", "type": "external" } ], "go_molecular_function": "GO:0008474 palmitoyl-(protein) hydrolase activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0055038 recycling endosome membrane;GO:0010008 endosome membrane;GO:0098839 postsynaptic density membrane", "go_biological_process": "GO:1905668 positive regulation of protein localization to endosome;GO:0099175 regulation of postsynapse organization;GO:1902817 negative regulation of protein localization to microtubule", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PKD9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PKG6-1", "uniprot_id": [ { "id": "UBE4A_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PKG6", "type": "external" } ], "mass": 122593.0, "length": 1067, "protein_name": "Ubiquitin conjugation factor E4 A", "gene_name": "UBE4A", "organism": "Bovine", "refseq_name": "ubiquitin conjugation factor E4 A", "refseq_ac": [ { "id": "NP_001092469", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092469", "type": "external" } ], "gene_names_uniprotkb": "UBE4A", "gene_names_refseq": "UBE4A", "protein_names_uniprotkb": "Ubiquitin conjugation factor E4 A; 2.3.2.27; RING-type E3 ubiquitin transferase E4 A", "protein_names_refseq": "RING-type E3 ubiquitin transferase E4 A; ubiquitin conjugation factor E4 A; ubiquitination factor E4A (UFD2 homolog, yeast)", "tax_id": 9913, "disease": "", "pathway": " (bta:517544); (R-BTA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. Mediates 'Lys-48'-linked polyubiquitination of substrates., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0034450 ubiquitin-ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0000209 protein polyubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PKG6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PKH3-1", "uniprot_id": [ { "id": "FAAA_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PKH3", "type": "external" } ], "mass": 46156.0, "length": 419, "protein_name": "Fumarylacetoacetase", "gene_name": "FAH", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FAH", "gene_names_refseq": "", "protein_names_uniprotkb": "Fumarylacetoacetase; 3.7.1.2; Beta-diketonase; FAA; Fumarylacetoacetate hydrolase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:508724)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "A7MBC9", "ec_number_list": [ { "id": "3.7.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.7.1.2", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0004334 fumarylacetoacetase activity", "go_cellular_component": "", "go_biological_process": "GO:0006629 lipid metabolic process;GO:0006559 L-phenylalanine catabolic process;GO:0006572 L-tyrosine catabolic process;GO:1902000 homogentisate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PKH3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PKK9-1", "uniprot_id": [ { "id": "FAP20_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PKK9", "type": "external" } ], "mass": 20654.0, "length": 192, "protein_name": "Fanconi anemia core complex-associated protein 20", "gene_name": "FAAP20", "organism": "Bovine", "refseq_name": "Fanconi anemia core complex-associated protein 20", "refseq_ac": [ { "id": "NP_001160036", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160036", "type": "external" } ], "gene_names_uniprotkb": "FAAP20", "gene_names_refseq": "C16H1orf86; FAAP20", "protein_names_uniprotkb": "Fanconi anemia core complex-associated protein 20; FANCA-associated protein of 20 kDa; Fanconi anemia-associated protein of 20 kDa", "protein_names_refseq": "FANCA-associated protein of 20 kDa; Fanconi anemia core complex associated protein 20; Fanconi anemia core complex-associated protein 20; Fanconi anemia-associated protein of 20 kDa; uncharacterized protein C1orf86 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:508039)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140036 ubiquitin-modified protein reader activity;GO:0008270 zinc ion binding;GO:0031593 polyubiquitin modification-dependent protein binding;GO:0043130 ubiquitin binding;GO:0070530 K63-linked polyubiquitin modification-dependent protein binding", "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005694 chromosome", "go_biological_process": "GO:0006974 DNA damage response;GO:0036297 interstrand cross-link repair;GO:0019985 translesion synthesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PKK9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A5PKL7-1", "uniprot_id": [ { "id": "LZTS2_BOVIN", "url": "https://www.uniprot.org/uniprot/A5PKL7", "type": "external" } ], "mass": 72466.0, "length": 667, "protein_name": "Leucine zipper putative tumor suppressor 2", "gene_name": "LZTS2", "organism": "Bovine", "refseq_name": "leucine zipper putative tumor suppressor 2", "refseq_ac": [ { "id": "NP_001092332", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092332", "type": "external" } ], "gene_names_uniprotkb": "LZTS2; LAPSER1", "gene_names_refseq": "LAPSER1; LZTS2", "protein_names_uniprotkb": "Leucine zipper putative tumor suppressor 2; Protein LAPSER1", "protein_names_refseq": "leucine zipper putative tumor suppressor 2; leucine zipper, putative tumor suppressor 2", "tax_id": 9913, "disease": "", "pathway": " (bta:504411)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin., [UniProtKB, HAMAP]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0030496 midbody", "go_biological_process": "GO:0051013 microtubule severing;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0016055 Wnt signaling pathway;GO:0000281 mitotic cytokinesis;GO:0051168 nuclear export", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A5PKL7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H6Z7-1", "uniprot_id": [ { "id": "TPX2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H6Z7", "type": "external" } ], "mass": 81593.0, "length": 704, "protein_name": "Targeting protein for Xklp2", "gene_name": "TPX2", "organism": "Bovine", "refseq_name": "targeting protein for Xklp2", "refseq_ac": [ { "id": "NP_001092368", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092368", "type": "external" } ], "gene_names_uniprotkb": "TPX2", "gene_names_refseq": "TPX2", "protein_names_uniprotkb": "Targeting protein for Xklp2", "protein_names_refseq": "TPX2, microtubule-associated protein homolog; TPX2, microtubule-associated, homolog; targeting protein for Xklp2", "tax_id": 9913, "disease": "", "pathway": " (bta:507226)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0043539 protein serine/threonine kinase activator activity", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005819 spindle;GO:0005874 microtubule;GO:0072686 mitotic spindle", "go_biological_process": "GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0006915 apoptotic process;GO:0060236 regulation of mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H6Z7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H768-1", "uniprot_id": [ { "id": "GALK1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H768", "type": "external" } ], "mass": 42227.0, "length": 392, "protein_name": "Galactokinase", "gene_name": "GALK1", "organism": "Bovine", "refseq_name": "galactokinase", "refseq_ac": [ { "id": "NP_001092851", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092851", "type": "external" } ], "gene_names_uniprotkb": "GALK1", "gene_names_refseq": "GALK1", "protein_names_uniprotkb": "Galactokinase; 2.7.1.6; Galactose kinase", "protein_names_refseq": "galactokinase; galactose kinase", "tax_id": 9913, "disease": "", "pathway": " (bta:530855); (R-BTA-70370)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Catalyzes the transfer of a phosphate from ATP to alpha-D-galactose and participates in the first committed step in the catabolism of galactose., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q1JP66", "ec_number_list": [ { "id": "2.7.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.6", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004335 galactokinase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0033499 galactose catabolic process via UDP-galactose, Leloir pathway;GO:0006012 galactose metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6H768-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H784-1", "uniprot_id": [ { "id": "SCO2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H784", "type": "external" } ], "mass": 29789.0, "length": 266, "protein_name": "Cytochrome c oxidase assembly factor SCO2", "gene_name": "SCO2", "organism": "Bovine", "refseq_name": "cytochrome c oxidase assembly factor SCO2 precursor", "refseq_ac": [ { "id": "NP_001098963", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098963", "type": "external" } ], "gene_names_uniprotkb": "SCO2", "gene_names_refseq": "SCO2", "protein_names_uniprotkb": "Cytochrome c oxidase assembly factor SCO2", "protein_names_refseq": "Protein SCO2 homolog, mitochondrial; SCO cytochrome oxidase deficient homolog 2; cytochrome c oxidase assembly factor SCO2 precursor; cytochrome c oxidase assembly factor SCO2", "tax_id": 9913, "disease": "", "pathway": " (bta:100125923); (R-BTA-9864848)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2); together with SCO1, facilitates the incorporation of copper into the Cu(A) site of MT-CO2/COX2. Could also act as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005507 copper ion binding;GO:0015035 protein-disulfide reductase activity;GO:0016531 copper chaperone activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0030016 myofibril", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0001654 eye development;GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H784-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H7B1-1", "uniprot_id": [ { "id": "TOM20_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H7B1", "type": "external" } ], "mass": 16298.0, "length": 145, "protein_name": "Mitochondrial import receptor subunit TOM20 homolog", "gene_name": "TOMM20", "organism": "Bovine", "refseq_name": "mitochondrial import receptor subunit TOM20 homolog", "refseq_ac": [ { "id": "NP_001092653", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092653", "type": "external" } ], "gene_names_uniprotkb": "TOMM20", "gene_names_refseq": "TOMM20", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM20 homolog; Mitochondrial 20 kDa outer membrane protein; Outer mitochondrial membrane receptor Tom20", "protein_names_refseq": "Mitochondrial outer membrane receptor TOM20 (MAS20P,S cervisiae homolog) acidic calcium-independent phospholipase A2; mitochondrial 20 kDa outer membrane protein; mitochondrial import receptor subunit TOM20 homolog; outer mitochondrial membrane receptor Tom20", "tax_id": 9913, "disease": "", "pathway": " (bta:781575); (R-BTA-5205685); (R-BTA-5689880)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with TOMM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0097225 sperm midpiece;GO:0005742 mitochondrial outer membrane translocase complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006626 protein targeting to mitochondrion;GO:0030150 protein import into mitochondrial matrix;GO:0016031 tRNA import into mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H7B1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H7F6-1", "uniprot_id": [ { "id": "GLP3L_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H7F6", "type": "external" } ], "mass": 32814.0, "length": 285, "protein_name": "Golgi phosphoprotein 3-like", "gene_name": "GOLPH3L", "organism": "Bovine", "refseq_name": "Golgi phosphoprotein 3-like", "refseq_ac": [ { "id": "NP_001092522", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092522", "type": "external" } ], "gene_names_uniprotkb": "GOLPH3L", "gene_names_refseq": "GOLPH3L", "protein_names_uniprotkb": "Golgi phosphoprotein 3-like", "protein_names_refseq": "Golgi phosphoprotein 3-like", "tax_id": 9913, "disease": "", "pathway": " (bta:532555)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphatidylinositol-4-phosphate-binding protein that may antagonize the action of GOLPH3 which is required for the process of vesicle budding at the Golgi and anterograde transport to the plasma membrane., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070273 phosphatidylinositol-4-phosphate binding;GO:0140312 cargo adaptor activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0032580 Golgi cisterna membrane;GO:0005802 trans-Golgi network;GO:0031985 Golgi cisterna", "go_biological_process": "GO:0050714 positive regulation of protein secretion;GO:0043001 Golgi to plasma membrane protein transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0007030 Golgi organization;GO:0048194 Golgi vesicle budding", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H7F6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6H7H1-1", "uniprot_id": [ { "id": "F120A_BOVIN", "url": "https://www.uniprot.org/uniprot/A6H7H1", "type": "external" } ], "mass": 121551.0, "length": 1114, "protein_name": "Constitutive coactivator of PPAR-gamma-like protein 1", "gene_name": "FAM120A", "organism": "Bovine", "refseq_name": "constitutive coactivator of PPAR-gamma-like protein 1", "refseq_ac": [ { "id": "NP_001092375", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092375", "type": "external" } ], "gene_names_uniprotkb": "FAM120A; OSSA", "gene_names_refseq": "FAM120A; OSSA", "protein_names_uniprotkb": "Constitutive coactivator of PPAR-gamma-like protein 1; Oxidative stress-associated Src activator; Protein FAM120A", "protein_names_refseq": "constitutive coactivator of PPAR-gamma-like protein 1; oxidative stress-associated Src activator; protein FAM120A", "tax_id": 9913, "disease": "", "pathway": " (bta:507997)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Membrane-associated scaffold protein that participates in multiple cellular processes, including oxidative stress-induced survival signaling, RNA trafficking and translational regulation, and the modulation of membrane signaling through its interaction with RNA-binding proteins and lipid raft-associated domains. Functions as a regulator of activation of several intracellular kinases, including SRC, FAK, and PI3K, following oxidative stress. Promotes RNA splicing and stability of lipogenic enzymes. Mechanistically, recruits the lipogenic transcription factor SREBP1 at active promoters, thereby bridging the newly transcribed lipogenic genes from RNA polymerase II to the SRSF1 and U1-70K-containing RNA-splicing machinery. Associates with key proteins of the NLRP3 inflammasome pathway and subsequently inhibits NLRP3 inflammasome activation (By similarity). Sequesters a subset of AGO2-bound mRNAs from miRNA-mediated silencing by binding to poly(G)-rich motifs in their 3'-UTR independently of the AGO2 binding site, likely by preventing recruitment of miRISC effectors (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6H7H1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QL72-1", "uniprot_id": [ { "id": "MTA3_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QL72", "type": "external" } ], "mass": 67207.0, "length": 590, "protein_name": "Metastasis-associated protein MTA3", "gene_name": "MTA3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MTA3", "gene_names_refseq": "", "protein_names_uniprotkb": "Metastasis-associated protein MTA3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:512854)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003713 transcription coactivator activity;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016581 NuRD complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QL72-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLA0-1", "uniprot_id": [ { "id": "NFX1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLA0", "type": "external" } ], "mass": 123581.0, "length": 1116, "protein_name": "Transcriptional repressor NF-X1", "gene_name": "NFX1", "organism": "Bovine", "refseq_name": "transcriptional repressor NF-X1", "refseq_ac": [ { "id": "NP_001095499", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095499", "type": "external" } ], "gene_names_uniprotkb": "NFX1", "gene_names_refseq": "NFX1", "protein_names_uniprotkb": "Transcriptional repressor NF-X1; 2.3.2.-; Nuclear transcription factor, X box-binding protein 1", "protein_names_refseq": "nuclear transcription factor, X box-binding protein 1; transcriptional repressor NF-X1", "tax_id": 9913, "disease": "", "pathway": " (bta:515680)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Together with PABPC1 or PABPC4, acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0016740 transferase activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLA0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLA4-1", "uniprot_id": [ { "id": "MAP1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLA4", "type": "external" } ], "mass": 43183.0, "length": 386, "protein_name": "Methionine aminopeptidase 1", "gene_name": "METAP1", "organism": "Bovine", "refseq_name": "methionine aminopeptidase 1", "refseq_ac": [ { "id": "NP_001095507", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095507", "type": "external" } ], "gene_names_uniprotkb": "METAP1", "gene_names_refseq": "METAP1", "protein_names_uniprotkb": "Methionine aminopeptidase 1; 3.4.11.18; MAP 1; MetAP 1; Peptidase M 1", "protein_names_refseq": "MAP 1; metAP 1; methionine aminopeptidase 1; peptidase M 1", "tax_id": 9913, "disease": "", "pathway": " (bta:516540); (R-BTA-2514859)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)., [UniProtKB, UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.11.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.18", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0070006 metalloaminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0006508 proteolysis;GO:0051604 protein maturation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLA4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLD2-1", "uniprot_id": [ { "id": "OLM2B_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLD2", "type": "external" } ], "mass": 84493.0, "length": 759, "protein_name": "Olfactomedin-like protein 2B", "gene_name": "OLFML2B", "organism": "Bovine", "refseq_name": "olfactomedin-like protein 2B precursor", "refseq_ac": [ { "id": "NP_001093824", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093824", "type": "external" } ], "gene_names_uniprotkb": "OLFML2B", "gene_names_refseq": "OLFML2B", "protein_names_uniprotkb": "Olfactomedin-like protein 2B", "protein_names_refseq": "olfactomedin-like protein 2B precursor; olfactomedin-like protein 2B", "tax_id": 9913, "disease": "", "pathway": " (bta:513053)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 3, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLD2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLH6-1", "uniprot_id": [ { "id": "SCYL1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLH6", "type": "external" } ], "mass": 89325.0, "length": 807, "protein_name": "N-terminal kinase-like protein", "gene_name": "SCYL1", "organism": "Bovine", "refseq_name": "N-terminal kinase-like protein", "refseq_ac": [ { "id": "NP_001095491", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095491", "type": "external" } ], "gene_names_uniprotkb": "SCYL1; NTKL", "gene_names_refseq": "SCYL1", "protein_names_uniprotkb": "N-terminal kinase-like protein; SCY1-like protein 1", "protein_names_refseq": "N-terminal kinase-like protein; SCY1-like 1; SCY1-like protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:515247)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum. Involved in the maintenance of the Golgi apparatus morphology., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004672 protein kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005813 centrosome;GO:0005801 cis-Golgi network;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0030126 COPI vesicle coat", "go_biological_process": "GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLH6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLJ3-1", "uniprot_id": [ { "id": "GUF1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLJ3", "type": "external" } ], "mass": 74766.0, "length": 669, "protein_name": "Translation factor GUF1, mitochondrial", "gene_name": "GUF1", "organism": "Bovine", "refseq_name": "translation factor GUF1, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001095537", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095537", "type": "external" } ], "gene_names_uniprotkb": "GUF1", "gene_names_refseq": "EF-4; GUF1", "protein_names_uniprotkb": "Translation factor GUF1, mitochondrial; 3.6.5.-; EF-4; Elongation factor 4 homolog; GTPase GUF1; Ribosomal back-translocase", "protein_names_refseq": "GTPase GUF1; GUF1 GTPase homolog; GUF1 homolog, GTPase; elongation factor 4 homolog; ribosomal back-translocase; translation factor GUF1, mitochondrial precursor; translation factor GUF1, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:522459)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner., [UniProtKB, HAMAP, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "3.6.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "3.6.5.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4", "type": "external" } ], "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0097177 mitochondrial ribosome binding;GO:0043022 ribosome binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006412 translation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLJ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLJ4-1", "uniprot_id": [ { "id": "C42S2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLJ4", "type": "external" } ], "mass": 9197.0, "length": 84, "protein_name": "CDC42 small effector protein 2", "gene_name": "CDC42SE2", "organism": "Bovine", "refseq_name": "CDC42 small effector protein 2", "refseq_ac": [ { "id": "NP_001096007", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096007", "type": "external" } ], "gene_names_uniprotkb": "CDC42SE2", "gene_names_refseq": "CDC42SE2", "protein_names_uniprotkb": "CDC42 small effector protein 2", "protein_names_refseq": "CDC42 small effector protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:789618)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031267 small GTPase binding;GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0006909 phagocytosis;GO:0035023 regulation of Rho protein signal transduction;GO:0008360 regulation of cell shape", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLJ4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLK4-1", "uniprot_id": [ { "id": "TMM8B_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLK4", "type": "external" } ], "mass": 52088.0, "length": 472, "protein_name": "Transmembrane protein 8B", "gene_name": "TMEM8B", "organism": "Bovine", "refseq_name": "transmembrane protein 8B", "refseq_ac": [ { "id": "NP_001096805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096805", "type": "external" } ], "gene_names_uniprotkb": "TMEM8B", "gene_names_refseq": "TMEM8B", "protein_names_uniprotkb": "Transmembrane protein 8B; Protein NGX6", "protein_names_refseq": "Protein NGX6; transmembrane protein 8B", "tax_id": 9913, "disease": "", "pathway": " (bta:100125302)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "A6QQL1", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLK4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLM0-1", "uniprot_id": [ { "id": "PEDS1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLM0", "type": "external" } ], "mass": 31285.0, "length": 271, "protein_name": "Plasmanylethanolamine desaturase 1", "gene_name": "PEDS1", "organism": "Bovine", "refseq_name": "plasmanylethanolamine desaturase 1", "refseq_ac": [ { "id": "NP_001093785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093785", "type": "external" } ], "gene_names_uniprotkb": "PEDS1; PEDS; TMEM189", "gene_names_refseq": "PEDS1; TMEM189", "protein_names_uniprotkb": "Plasmanylethanolamine desaturase 1; 1.14.19.77; Transmembrane protein 189", "protein_names_refseq": "plasmanylethanolamine desaturase 1; transmembrane protein 189", "tax_id": 9913, "disease": "", "pathway": " (bta:507694)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plasmanylethanolamine desaturase involved in plasmalogen biogenesis in the endoplasmic reticulum membrane. Plasmalogens are glycerophospholipids with a hydrocarbon chain linked by a vinyl ether bond at the glycerol sn-1 position, and are involved in antioxidative and signaling mechanisms., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.19.77", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.77", "type": "external" } ], "go_molecular_function": "GO:0050207 plasmanylethanolamine desaturase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0008611 ether lipid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLM0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLQ8-1", "uniprot_id": [ { "id": "ENDOU_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLQ8", "type": "external" } ], "mass": 47188.0, "length": 413, "protein_name": "Uridylate-specific endoribonuclease", "gene_name": "ENDOU", "organism": "Bovine", "refseq_name": "uridylate-specific endoribonuclease precursor", "refseq_ac": [ { "id": "NP_001095560", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095560", "type": "external" } ], "gene_names_uniprotkb": "ENDOU", "gene_names_refseq": "ENDOU; P11", "protein_names_uniprotkb": "Uridylate-specific endoribonuclease; 3.1.-.-; 4.6.1.-; Protein endoU", "protein_names_refseq": "26 serine protease; endonuclease, polyU-specific; poly(U)-specific endoribonuclease; protein endoU; uridylate-specific endoribonuclease precursor; uridylate-specific endoribonuclease", "tax_id": 9913, "disease": "", "pathway": " (bta:525399)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Endoribonuclease that cleaves single-stranded RNAs at 5' of uridylates and releases a product with a 2',3'-cyclic phosphate at the 3'-end. The UU and GU sites are more efficiently cleaved than CU and AU sites. Targets mRNAs to regulate their expression (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.6.1.-", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" } ], "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0003723 RNA binding;GO:0005044 scavenger receptor activity;GO:0016787 hydrolase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006955 immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QLQ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QLU3-1", "uniprot_id": [ { "id": "GAB1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QLU3", "type": "external" } ], "mass": 76435.0, "length": 694, "protein_name": "GRB2-associated-binding protein 1", "gene_name": "GAB1", "organism": "Bovine", "refseq_name": "GRB2-associated-binding protein 1", "refseq_ac": [ { "id": "NP_001094671", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094671", "type": "external" } ], "gene_names_uniprotkb": "GAB1", "gene_names_refseq": "GAB1", "protein_names_uniprotkb": "GRB2-associated-binding protein 1; GRB2-associated binder 1; Growth factor receptor bound protein 2-associated protein 1", "protein_names_refseq": "GRB2-associated binder 1; GRB2-associated-binding protein 1; growth factor receptor bound protein 2-associated protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:540085); (R-BTA-109704); (R-BTA-1257604); (R-BTA-180292); (R-BTA-1963642); (R-BTA-5654689); (R-BTA-5654695); (R-BTA-5654710); (R-BTA-5654720); (R-BTA-6811558); (R-BTA-8851907); (R-BTA-8853659); (R-BTA-8865999); (R-BTA-8875555); (R-BTA-8875656); (R-BTA-9027276)", "pathway_count": 16, "publication_count": 3, "publication_id_list": "15078886;15665327;17178724", "class_list": "", "function": "Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway., [UniProtKB, UniProtKB]; Gab1 is a novel critical regulatory component of endothelial cell migration and capillary formation with a key role in the activation of VEGF-evoked signaling pathways required for angiogenesis, [RefSeq, PubMed]; Gab1 tyrosine phosphorylation is stimulated by flow shear stress to mediate protein kinase B and endothelial nitric-oxide synthase activation in endothelial cells, [RefSeq, PubMed]; These data suggest that Gab1-ERK1/2 binding and their nuclear translocation play a crucial role in Egr-1 nuclear accumulation., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035591 signaling adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005911 cell-cell junction", "go_biological_process": "GO:0007165 signal transduction;GO:0001525 angiogenesis;GO:0045766 positive regulation of angiogenesis;GO:0035767 endothelial cell chemotaxis;GO:0038084 vascular endothelial growth factor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A6QLU3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNM3-1", "uniprot_id": [ { "id": "ORC2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNM3", "type": "external" } ], "mass": 66263.0, "length": 577, "protein_name": "Origin recognition complex subunit 2", "gene_name": "ORC2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ORC2; ORC2L", "gene_names_refseq": "", "protein_names_uniprotkb": "Origin recognition complex subunit 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:511281)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3 (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003688 DNA replication origin binding", "go_cellular_component": "GO:0005664 nuclear origin of replication recognition complex", "go_biological_process": "GO:0006260 DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QNM3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNP9-1", "uniprot_id": [ { "id": "CCD69_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNP9", "type": "external" } ], "mass": 34021.0, "length": 294, "protein_name": "Coiled-coil domain-containing protein 69", "gene_name": "CCDC69", "organism": "Bovine", "refseq_name": "coiled-coil domain-containing protein 69", "refseq_ac": [ { "id": "NP_001193553", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193553", "type": "external" } ], "gene_names_uniprotkb": "CCDC69", "gene_names_refseq": "CCDC69", "protein_names_uniprotkb": "Coiled-coil domain-containing protein 69", "protein_names_refseq": "coiled-coil domain-containing protein 69", "tax_id": 9913, "disease": "", "pathway": " (bta:529878)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a scaffold to regulate the recruitment and assembly of spindle midzone components. Required for the localization of AURKB and PLK1 to the spindle midzone., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding", "go_cellular_component": "GO:0005634 nucleus;GO:0051233 spindle midzone;GO:0030496 midbody", "go_biological_process": "GO:0051255 spindle midzone assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QNP9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNX5-1", "uniprot_id": [ { "id": "K2C78_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNX5", "type": "external" } ], "mass": 57464.0, "length": 528, "protein_name": "Keratin, type II cytoskeletal 78", "gene_name": "KRT78", "organism": "Bovine", "refseq_name": "keratin, type II cytoskeletal 78", "refseq_ac": [ { "id": "NP_001095547", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095547", "type": "external" } ], "gene_names_uniprotkb": "KRT78", "gene_names_refseq": "KRT78", "protein_names_uniprotkb": "Keratin, type II cytoskeletal 78; CK-78; Cytokeratin-78; K78; Keratin-78; Type-II keratin Kb40", "protein_names_refseq": "CK-78; K78; cytokeratin-78; keratin, type II cytoskeletal 78; type-II keratin Kb40", "tax_id": 9913, "disease": "", "pathway": " (bta:523221); (R-BTA-6805567); (R-BTA-6809371)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "41018975", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 1, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 1, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 1, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 1, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 0, "biomarker_type": "", "glycan_count": 1, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0045095 keratin filament", "go_biological_process": "GO:0031424 keratinization;GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.4, "record_id": "A6QNX5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0100000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QNZ0-1", "uniprot_id": [ { "id": "ZSC26_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QNZ0", "type": "external" } ], "mass": 55276.0, "length": 479, "protein_name": "Zinc finger and SCAN domain-containing protein 26", "gene_name": "ZSCAN26", "organism": "Bovine", "refseq_name": "zinc finger and SCAN domain-containing protein 26", "refseq_ac": [ { "id": "NP_001095427", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095427", "type": "external" } ], "gene_names_uniprotkb": "ZSCAN26; ZNF187", "gene_names_refseq": "ZNF187; ZSCAN26", "protein_names_uniprotkb": "Zinc finger and SCAN domain-containing protein 26; Zinc finger protein 187", "protein_names_refseq": "zinc finger and SCAN domain-containing protein 26; zinc finger protein 187", "tax_id": 9913, "disease": "", "pathway": " (bta:512445)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in transcriptional regulation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QNZ0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QP11-1", "uniprot_id": [ { "id": "SNP47_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QP11", "type": "external" } ], "mass": 47359.0, "length": 420, "protein_name": "Synaptosomal-associated protein 47", "gene_name": "SNAP47", "organism": "Bovine", "refseq_name": "synaptosomal-associated protein 47", "refseq_ac": [ { "id": "NP_001095790", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095790", "type": "external" } ], "gene_names_uniprotkb": "SNAP47", "gene_names_refseq": "C1orf142; C7H1orf142; SNAP47", "protein_names_uniprotkb": "Synaptosomal-associated protein 47; SNAP-47; Synaptosomal-associated 47 kDa protein", "protein_names_refseq": "SNAP-47; synaptosomal-associated 47 kDa protein; synaptosomal-associated protein 47; synaptosomal-associated protein, 47kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:618546)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19546860", "class_list": "", "function": "May play a role in intracellular membrane fusion., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding;GO:0005484 SNAP receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0012505 endomembrane system;GO:0098793 presynapse;GO:0031201 SNARE complex", "go_biological_process": "GO:0006887 exocytosis;GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane;GO:0016082 synaptic vesicle priming", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QP11-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QP15-1", "uniprot_id": [ { "id": "HOT_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QP15", "type": "external" } ], "mass": 50343.0, "length": 466, "protein_name": "Hydroxyacid-oxoacid transhydrogenase, mitochondrial", "gene_name": "ADHFE1", "organism": "Bovine", "refseq_name": "hydroxyacid-oxoacid transhydrogenase, mitochondrial", "refseq_ac": [ { "id": "NP_001095357", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095357", "type": "external" } ], "gene_names_uniprotkb": "ADHFE1", "gene_names_refseq": "ADHFE1", "protein_names_uniprotkb": "Hydroxyacid-oxoacid transhydrogenase, mitochondrial; 1.1.99.24; ADHFe1; Alcohol dehydrogenase iron-containing protein 1; HOT", "protein_names_refseq": "HOT; alcohol dehydrogenase iron-containing protein 1; hydroxyacid-oxoacid transhydrogenase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:507711); (R-BTA-880009)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.99.24", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.99.24", "type": "external" } ], "go_molecular_function": "GO:0047988 hydroxyacid-oxoacid transhydrogenase activity;GO:0004022 alcohol dehydrogenase (NAD+) activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0046952 ketone body catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QP15-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QP29-1", "uniprot_id": [ { "id": "TBD2A_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QP29", "type": "external" } ], "mass": 105045.0, "length": 925, "protein_name": "TBC1 domain family member 2A", "gene_name": "TBC1D2", "organism": "Bovine", "refseq_name": "TBC1 domain family member 2A", "refseq_ac": [ { "id": "NP_001095451", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095451", "type": "external" } ], "gene_names_uniprotkb": "TBC1D2; TBC1D2A", "gene_names_refseq": "TBC1D2", "protein_names_uniprotkb": "TBC1 domain family member 2A", "protein_names_refseq": "TBC1 domain family member 2A", "tax_id": 9913, "disease": "", "pathway": " (bta:513828); (R-BTA-8854214)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a GTPase-activating protein for Rab family protein(s). Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and further inhibition of cadherin degradation (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0043547 positive regulation of GTPase activity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QP29-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QP81-1", "uniprot_id": [ { "id": "MT21C_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QP81", "type": "external" } ], "mass": 28904.0, "length": 257, "protein_name": "Protein-lysine methyltransferase METTL21C", "gene_name": "METTL21C", "organism": "Bovine", "refseq_name": "protein-lysine methyltransferase METTL21C", "refseq_ac": [ { "id": "NP_001093853", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093853", "type": "external" } ], "gene_names_uniprotkb": "METTL21C", "gene_names_refseq": "C12H13orf39; METTL21C", "protein_names_uniprotkb": "Protein-lysine methyltransferase METTL21C; 2.1.1.-; Methyltransferase-like protein 21C", "protein_names_refseq": "methyltransferase like 21C; methyltransferase-like protein 21C; protein-lysine methyltransferase METTL21C", "tax_id": 9913, "disease": "", "pathway": " (bta:519447)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Protein-lysine N-methyltransferase using S-adenosyl-L-methionine as methyl donor. Mono-di and trimethylates 'Lys-943' of AARS1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "3.4.24.71", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.71", "type": "external" } ], "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0008276 protein methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006479 protein methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QP81-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPA0-1", "uniprot_id": [ { "id": "SHSA2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPA0", "type": "external" } ], "mass": 30510.0, "length": 289, "protein_name": "Protein shisa-2 homolog", "gene_name": "SHISA2", "organism": "Bovine", "refseq_name": "protein shisa-2 homolog precursor", "refseq_ac": [ { "id": "NP_001094735", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094735", "type": "external" } ], "gene_names_uniprotkb": "SHISA2; TMEM46", "gene_names_refseq": "SHISA2; TMEM46", "protein_names_uniprotkb": "Protein shisa-2 homolog; Transmembrane protein 46", "protein_names_refseq": "protein shisa-2 homolog precursor; protein shisa-2 homolog; shisa homolog 2; transmembrane protein 46", "tax_id": 9913, "disease": "", "pathway": " (bta:617336)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0030178 negative regulation of Wnt signaling pathway;GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QPA0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPC8-1", "uniprot_id": [ { "id": "EID3_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPC8", "type": "external" } ], "mass": 42969.0, "length": 379, "protein_name": "EP300-interacting inhibitor of differentiation 3", "gene_name": "EID3", "organism": "Bovine", "refseq_name": "EP300-interacting inhibitor of differentiation 3", "refseq_ac": [ { "id": "NP_001093782", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093782", "type": "external" } ], "gene_names_uniprotkb": "EID3", "gene_names_refseq": "EID3; NS4EB", "protein_names_uniprotkb": "EP300-interacting inhibitor of differentiation 3; EID-1-like inhibitor of differentiation 3; EID-3; NS4EB; Non-SMC element 4 homolog B; Non-structural maintenance of chromosomes element 4 homolog B", "protein_names_refseq": "EID-1-like inhibitor of differentiation 3; EID-3; EP300-interacting inhibitor of differentiation 3; non-SMC element 4 homolog B; non-structural maintenance of chromosomes element 4 homolog B", "tax_id": 9913, "disease": "", "pathway": " (bta:507232)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors (By similarity)., [UniProtKB]; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000781 chromosome, telomeric region;GO:0030915 Smc5-Smc6 complex", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QPC8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPI6-1", "uniprot_id": [ { "id": "TOM22_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPI6", "type": "external" } ], "mass": 15292.0, "length": 140, "protein_name": "Mitochondrial import receptor subunit TOM22 homolog", "gene_name": "TOMM22", "organism": "Bovine", "refseq_name": "mitochondrial import receptor subunit TOM22 homolog", "refseq_ac": [ { "id": "NP_001093805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093805", "type": "external" } ], "gene_names_uniprotkb": "TOMM22", "gene_names_refseq": "TOMM22; Tom22", "protein_names_uniprotkb": "Mitochondrial import receptor subunit TOM22 homolog; Translocase of outer membrane 22 kDa subunit homolog", "protein_names_refseq": "Translocase of outer membrane 22 kDa subunit homolog; mitochondrial import receptor Tom22; mitochondrial import receptor subunit TOM22 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:510780); (R-BTA-5205685)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "20109159", "class_list": "", "function": "Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with the peripheral receptor TOMM20, functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Data demonstrate that LktA interacts with the Tom22 and Tom40 components of the translocase of the outer mitochondrial membrane (TOM), which suggests that import of this toxin into mitochondria involves a classical import pathway for endogenous proteins., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030943 mitochondrion targeting sequence binding", "go_cellular_component": "GO:0005742 mitochondrial outer membrane translocase complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006626 protein targeting to mitochondrion;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QPI6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPL2-1", "uniprot_id": [ { "id": "FNDC4_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPL2", "type": "external" } ], "mass": 24753.0, "length": 230, "protein_name": "Fibronectin type III domain-containing protein 4", "gene_name": "FNDC4", "organism": "Bovine", "refseq_name": "fibronectin type III domain-containing protein 4 precursor", "refseq_ac": [ { "id": "NP_001095794", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095794", "type": "external" } ], "gene_names_uniprotkb": "FNDC4; FRCP1", "gene_names_refseq": "FNDC4; FRCP1", "protein_names_uniprotkb": "Fibronectin type III domain-containing protein 4; Fibronectin type III repeat-containing protein 1", "protein_names_refseq": "Fibronectin type III domain-containing protein 4; Fibronectin type III repeat-containing protein 1; fibronectin type III domain-containing protein 4 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:781806)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "32881638", "class_list": "", "function": "Fibronectin type III domain-containing 4 promotes the migration and differentiation of bovine skeletal muscle-derived satellite cells via focal adhesion kinase., [RefSeq, PubMed]; Has anti-inflammatory properties. In the colon, acts on macrophages to down-regulate inflammation. May suppress osteoclastogenesis and mature osteoclast resorptive function. In white adipose tissue, decreases local inflammation, via interaction with GPR116. Also required for proper systemic glucose tolerance, specifically sensitizing white adipocytes to insulin and promoting glucose uptake. The insulin sensitizing function in adipose tissue is mediated by interaction with ADGRF5/GPR116 and activation of cAMP signaling., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0071559 response to transforming growth factor beta;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QPL2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPM3-1", "uniprot_id": [ { "id": "PRDM6_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPM3", "type": "external" } ], "mass": 63989.0, "length": 590, "protein_name": "Putative histone-lysine N-methyltransferase PRDM6", "gene_name": "PRDM6", "organism": "Bovine", "refseq_name": "putative histone-lysine N-methyltransferase PRDM6", "refseq_ac": [ { "id": "NP_001096725", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096725", "type": "external" } ], "gene_names_uniprotkb": "PRDM6", "gene_names_refseq": "PRDM6", "protein_names_uniprotkb": "Putative histone-lysine N-methyltransferase PRDM6; 2.1.1.361; PR domain zinc finger protein 6; PR domain-containing protein 6", "protein_names_refseq": "PR domain containing 6; PR domain zinc finger protein 6; PR domain-containing protein 6; putative histone-lysine N-methyltransferase PRDM6", "tax_id": 9913, "disease": "", "pathway": " (bta:519857)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Putative histone methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. Promotes the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. Also plays a role in endothelial cells by inhibiting endothelial cell proliferation, survival and differentiation. It is unclear whether it has histone methyltransferase activity in vivo. According to some authors, it does not act as a histone methyltransferase by itself and represses transcription by recruiting EHMT2/G9a. According to others, it possesses histone methyltransferase activity when associated with other proteins and specifically methylates 'Lys-20' of histone H4 in vitro. 'Lys-20' methylation represents a specific tag for epigenetic transcriptional repression., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0140944 histone H4K20 monomethyltransferase activity", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0010468 regulation of gene expression;GO:0032259 methylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QPM3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPM6-1", "uniprot_id": [ { "id": "PPR35_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPM6", "type": "external" } ], "mass": 28726.0, "length": 266, "protein_name": "Protein phosphatase 1 regulatory subunit 35", "gene_name": "PPP1R35", "organism": "Bovine", "refseq_name": "protein phosphatase 1 regulatory subunit 35", "refseq_ac": [ { "id": "NP_001095785", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095785", "type": "external" } ], "gene_names_uniprotkb": "PPP1R35", "gene_names_refseq": "C25H7ORF47; PPP1R35", "protein_names_uniprotkb": "Protein phosphatase 1 regulatory subunit 35", "protein_names_refseq": "UPF0683 protein C7orf47 homolog; protein phosphatase 1 regulatory subunit 35", "tax_id": 9913, "disease": "", "pathway": " (bta:617968)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with RTTN, leading to the centriole to centrosome conversion (By similarity). In addition may play a role in the primary cilia assembly (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "F1MCE9", "ec_number_list": [], "go_molecular_function": "GO:0004864 protein phosphatase inhibitor activity;GO:0019902 phosphatase binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005814 centriole", "go_biological_process": "GO:0048570 notochord morphogenesis;GO:0045724 positive regulation of cilium assembly;GO:1903724 positive regulation of centriole elongation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QPM6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPN6-1", "uniprot_id": [ { "id": "GILT_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPN6", "type": "external" } ], "mass": 27490.0, "length": 244, "protein_name": "Gamma-interferon-inducible lysosomal thiol reductase", "gene_name": "IFI30", "organism": "Bovine", "refseq_name": "gamma-interferon-inducible lysosomal thiol reductase precursor", "refseq_ac": [ { "id": "NP_001094721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094721", "type": "external" } ], "gene_names_uniprotkb": "IFI30", "gene_names_refseq": "IFI30", "protein_names_uniprotkb": "Gamma-interferon-inducible lysosomal thiol reductase; 1.8.4.-; IFI30 protein", "protein_names_refseq": "gamma-inducible protein 30; gamma-interferon-inducible lysosomal thiol reductase precursor; gamma-interferon-inducible lysosomal thiol reductase; interferon, gamma-inducible protein 30", "tax_id": 9913, "disease": "", "pathway": " (bta:615930); (R-BTA-2132295)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Lysosomal thiol reductase that catalyzes protein disulfide bonds reduction. Plays an important role in antigen processing and presentation, of namely both major histocompatibility complex (MHC) class I- and class II-restricted antigen by reducing the disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation. Shares with thioredoxin a reduction mechanism in which the N-terminal cysteine thiol group in the CXXC active site motif initiates a nucleophilic attack on the substrate disulfide bond,resulting in the formation of a mixed disulfide-linked enzyme-substrate intermediate. Subsequent intramolecular attack by the second cysteine thiol group enables the release of the reduced substrate and oxidized enzyme. Lysosomal cysteine is a physiological reducing agent that is capable of reducing IFI30, so that it can catalyzes the next reaction. Dithiothreitol, cysteine, and cysteinyl glycine, but not glutathione, are capable of regenerating active precursor and mature IFI30 in vitro., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.-", "type": "external" } ], "go_molecular_function": "GO:0016667 oxidoreductase activity, acting on a sulfur group of donors;GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "go_cellular_component": "GO:0005576 extracellular region;GO:0005764 lysosome", "go_biological_process": "GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QPN6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPR9-1", "uniprot_id": [ { "id": "TEFM_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPR9", "type": "external" } ], "mass": 40608.0, "length": 356, "protein_name": "Transcription elongation factor, mitochondrial", "gene_name": "TEFM", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TEFM", "gene_names_refseq": "", "protein_names_uniprotkb": "Transcription elongation factor, mitochondrial", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription elongation factor which increases mitochondrial RNA polymerase processivity. Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0003711 transcription elongation factor activity", "go_cellular_component": "GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0006392 transcription elongation by mitochondrial RNA polymerase;GO:1903109 positive regulation of mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QPR9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPU5-1", "uniprot_id": [ { "id": "SYDM_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPU5", "type": "external" } ], "mass": 73688.0, "length": 651, "protein_name": "Aspartate--tRNA ligase, mitochondrial", "gene_name": "DARS2", "organism": "Bovine", "refseq_name": "aspartate--tRNA ligase, mitochondrial precursor", "refseq_ac": [ { "id": "NP_001095692", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095692", "type": "external" } ], "gene_names_uniprotkb": "DARS2", "gene_names_refseq": "DARS2", "protein_names_uniprotkb": "Aspartate--tRNA ligase, mitochondrial; 6.1.1.12; AspRS; Aspartyl-tRNA synthetase", "protein_names_refseq": "aspRS; aspartate--tRNA ligase, mitochondrial precursor; aspartate--tRNA ligase, mitochondrial; aspartyl-tRNA synthetase, mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:538772)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30573663", "class_list": "", "function": "Catalyzes the attachment of aspartate to tRNA(Asp) in a two-step reaction: aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" } ], "go_molecular_function": "GO:0004815 aspartate-tRNA ligase activity;GO:0005524 ATP binding;GO:0003676 nucleic acid binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0070145 mitochondrial asparaginyl-tRNA aminoacylation;GO:0006422 aspartyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QPU5-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QPY0-1", "uniprot_id": [ { "id": "OST48_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QPY0", "type": "external" } ], "mass": 48791.0, "length": 439, "protein_name": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit", "gene_name": "DDOST", "organism": "Bovine", "refseq_name": "dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor", "refseq_ac": [ { "id": "NP_001094543", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094543", "type": "external" } ], "gene_names_uniprotkb": "DDOST", "gene_names_refseq": "DDOST", "protein_names_uniprotkb": "Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; DDOST 48 kDa subunit; Oligosaccharyl transferase 48 kDa subunit", "protein_names_refseq": "DDOST 48 kDa subunit; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; dolichyl-diphosphooligosaccharide-protein glycosyltransferase; oligosaccharyl transferase 48 kDa subunit", "tax_id": 9913, "disease": "", "pathway": " (bta:510682)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "16305752", "class_list": "", "function": "Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "Q0V8D4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0008250 oligosaccharyltransferase complex", "go_biological_process": "GO:0009101 glycoprotein biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A6QPY0-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQ07-1", "uniprot_id": [ { "id": "BTD_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQ07", "type": "external" } ], "mass": 58353.0, "length": 525, "protein_name": "Biotinidase", "gene_name": "BTD", "organism": "Bovine", "refseq_name": "biotinidase precursor", "refseq_ac": [ { "id": "NP_001095676", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095676", "type": "external" } ], "gene_names_uniprotkb": "BTD", "gene_names_refseq": "BTD; Biotinase", "protein_names_uniprotkb": "Biotinidase; 3.5.1.12; Biotinase", "protein_names_refseq": "biotinidase precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:537669)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.12", "type": "external" } ], "go_molecular_function": "GO:0047708 biotinidase activity", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006768 biotin metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQ07-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQ47-1", "uniprot_id": [ { "id": "VPS51_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQ47", "type": "external" } ], "mass": 85930.0, "length": 781, "protein_name": "Vacuolar protein sorting-associated protein 51 homolog", "gene_name": "VPS51", "organism": "Bovine", "refseq_name": "vacuolar protein sorting-associated protein 51 homolog", "refseq_ac": [ { "id": "NP_001095563", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095563", "type": "external" } ], "gene_names_uniprotkb": "VPS51; FFR", "gene_names_refseq": "C29H11orf2; FFR; VPS51", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 51 homolog; Protein fat-free homolog", "protein_names_refseq": "VPS51, GARP complex subunit; protein fat-free homolog; vacuolar protein sorting 51 homolog; vacuolar protein sorting-associated protein 51 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:525567)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000938 GARP complex;GO:1990745 EARP complex;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0006869 lipid transport;GO:0015031 protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0007030 Golgi organization;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQ47-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQ74-1", "uniprot_id": [ { "id": "HYPDH_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQ74", "type": "external" } ], "mass": 51262.0, "length": 461, "protein_name": "Hydroxyproline dehydrogenase", "gene_name": "PRODH2", "organism": "Bovine", "refseq_name": "hydroxyproline dehydrogenase", "refseq_ac": [ { "id": "NP_001098437", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098437", "type": "external" } ], "gene_names_uniprotkb": "PRODH2; HYPDH", "gene_names_refseq": "HYPDH; PRODH2", "protein_names_uniprotkb": "Hydroxyproline dehydrogenase; 1.5.5.2; 1.5.5.3; HYPDH; Probable proline dehydrogenase 2; Probable proline oxidase 2", "protein_names_refseq": "hydroxyproline dehydrogenase; probable proline dehydrogenase 2; probable proline oxidase 2; proline dehydrogenase (oxidase) 2", "tax_id": 9913, "disease": "", "pathway": " (bta:508542)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.5.5.3", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.5.3", "type": "external" }, { "id": "1.5.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.5.5.2", "type": "external" } ], "go_molecular_function": "GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors;GO:0071949 FAD binding;GO:0004657 proline dehydrogenase activity", "go_cellular_component": "GO:0005739 mitochondrion", "go_biological_process": "GO:0010133 L-proline catabolic process to L-glutamate", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQ74-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQ91-1", "uniprot_id": [ { "id": "RASL3_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQ91", "type": "external" } ], "mass": 110755.0, "length": 1012, "protein_name": "RAS protein activator like-3", "gene_name": "RASAL3", "organism": "Bovine", "refseq_name": "RAS protein activator like-3", "refseq_ac": [ { "id": "NP_001095706", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095706", "type": "external" } ], "gene_names_uniprotkb": "RASAL3", "gene_names_refseq": "RASAL3", "protein_names_uniprotkb": "RAS protein activator like-3", "protein_names_refseq": "RAS protein activator like-3", "tax_id": 9913, "disease": "", "pathway": " (bta:540027)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 13, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0098562 cytoplasmic side of membrane", "go_biological_process": "GO:0051142 positive regulation of NK T cell proliferation;GO:0046580 negative regulation of Ras protein signal transduction;GO:1902531 regulation of intracellular signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQ91-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQJ3-1", "uniprot_id": [ { "id": "PERI_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQJ3", "type": "external" } ], "mass": 53631.0, "length": 469, "protein_name": "Peripherin", "gene_name": "PRPH", "organism": "Bovine", "refseq_name": "peripherin", "refseq_ac": [ { "id": "NP_001095848", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095848", "type": "external" } ], "gene_names_uniprotkb": "PRPH", "gene_names_refseq": "PRPH", "protein_names_uniprotkb": "Peripherin", "protein_names_refseq": "peripherin", "tax_id": 9913, "disease": "", "pathway": " (bta:510082)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Class-III neuronal intermediate filament protein (By similarity). May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network (By similarity). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (By similarity). Plays a role in the development of unmyelinated sensory neurons (By similarity). May be involved in axon elongation and axon regeneration after injury (By similarity). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0043204 perikaryon;GO:0045098 type III intermediate filament", "go_biological_process": "GO:0045109 intermediate filament organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQJ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QQV9-1", "uniprot_id": [ { "id": "AF1L1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QQV9", "type": "external" } ], "mass": 85931.0, "length": 763, "protein_name": "Actin filament-associated protein 1-like 1", "gene_name": "AFAP1L1", "organism": "Bovine", "refseq_name": "actin filament-associated protein 1-like 1", "refseq_ac": [ { "id": "NP_001093804", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093804", "type": "external" } ], "gene_names_uniprotkb": "AFAP1L1", "gene_names_refseq": "AFAP1L1", "protein_names_uniprotkb": "Actin filament-associated protein 1-like 1; AFAP1-like protein 1", "protein_names_refseq": "AFAP1-like protein 1; actin filament-associated protein 1-like 1", "tax_id": 9913, "disease": "", "pathway": " (bta:510738)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May be involved in podosome and invadosome formation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005829 cytosol;GO:0002102 podosome;GO:0001725 stress fiber;GO:0042995 cell projection;GO:0005737 cytoplasm", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QQV9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QR11-1", "uniprot_id": [ { "id": "NELL2_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QR11", "type": "external" } ], "mass": 91270.0, "length": 816, "protein_name": "Protein kinase C-binding protein NELL2", "gene_name": "NELL2", "organism": "Bovine", "refseq_name": "protein kinase C-binding protein NELL2 precursor", "refseq_ac": [ { "id": "NP_001095554", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095554", "type": "external" } ], "gene_names_uniprotkb": "NELL2", "gene_names_refseq": "NELL2", "protein_names_uniprotkb": "Protein kinase C-binding protein NELL2; NEL-like protein 2", "protein_names_refseq": "NEL-like 2; NEL-like protein 2; Protein kinase C-binding protein NELL2; protein kinase C-binding protein NELL2 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:524622)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays multiple roles in neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions. Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway (By similarity). Via binding to its receptor ROBO3, plays a role in axon guidance, functions as a repulsive guidance cue for commissural axons, helping to steer them across the spinal cord midline (By similarity). Required for neuron survival through the modulation of MAPK signaling pathways too. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Testicular luminal protein that signals through a ROS1-pathway to regulate the epididymal initial segment (IS) maturation, sperm maturation and male fertility., [UniProtKB, UniProtKB]", "predicted_glycosites": 8, "predicted_n_glycosites": 7, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 8, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0005080 protein kinase C binding;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm", "go_biological_process": "GO:0009566 fertilization;GO:0071679 commissural neuron axon guidance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QR11-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A6QR54-1", "uniprot_id": [ { "id": "JKIP1_BOVIN", "url": "https://www.uniprot.org/uniprot/A6QR54", "type": "external" } ], "mass": 73271.0, "length": 626, "protein_name": "Janus kinase and microtubule-interacting protein 1", "gene_name": "JAKMIP1", "organism": "Bovine", "refseq_name": "janus kinase and microtubule-interacting protein 1", "refseq_ac": [ { "id": "NP_001095721", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095721", "type": "external" } ], "gene_names_uniprotkb": "JAKMIP1", "gene_names_refseq": "JAKMIP1", "protein_names_uniprotkb": "Janus kinase and microtubule-interacting protein 1", "protein_names_refseq": "janus kinase and microtubule-interacting protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:540970)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0019900 kinase binding;GO:0050811 GABA receptor binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005874 microtubule;GO:0016020 membrane;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0015031 protein transport;GO:0050890 cognition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A6QR54-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7E3W2-1", "uniprot_id": [ { "id": "LG3BP_BOVIN", "url": "https://www.uniprot.org/uniprot/A7E3W2", "type": "external" } ], "mass": 62127.0, "length": 555, "protein_name": "Galectin-3-binding protein", "gene_name": "LGALS3BP", "organism": "Bovine", "refseq_name": "galectin-3-binding protein precursor", "refseq_ac": [ { "id": "NP_001039781", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001039781", "type": "external" } ], "gene_names_uniprotkb": "LGALS3BP", "gene_names_refseq": "LGALS3BP", "protein_names_uniprotkb": "Galectin-3-binding protein; Lectin galactoside-binding soluble 3-binding protein", "protein_names_refseq": "galectin-3-binding protein precursor; lectin galactoside-binding soluble 3-binding protein", "tax_id": 9913, "disease": "", "pathway": " (bta:531137); (R-BTA-114608)", "pathway_count": 2, "publication_count": 2, "publication_id_list": "16305752;21610087", "class_list": "", "function": "Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The relative abundance of PIBF, LGALS1, LGALS3, LGALS3BP, and LGALS9 mRNA would display a differential expression pattern in the endometrium., [RefSeq, PubMed]", "predicted_glycosites": 5, "predicted_n_glycosites": 5, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "Q2KJF4", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0007155 cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "A7E3W2-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB10-1", "uniprot_id": [ { "id": "RRP5_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB10", "type": "external" } ], "mass": 208543.0, "length": 1874, "protein_name": "Protein RRP5 homolog", "gene_name": "PDCD11", "organism": "Bovine", "refseq_name": "protein RRP5 homolog", "refseq_ac": [ { "id": "NP_001095573", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095573", "type": "external" } ], "gene_names_uniprotkb": "PDCD11", "gene_names_refseq": "PDCD11", "protein_names_uniprotkb": "Protein RRP5 homolog; Programmed cell death protein 11", "protein_names_refseq": "Programmed cell death protein 11; protein RRP5 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:526867)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential for the generation of mature 18S rRNA, specifically necessary for cleavages at sites A0, 1 and 2 of the 47S precursor. Directly interacts with U3 snoRNA (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0032040 small-subunit processome", "go_biological_process": "GO:0006364 rRNA processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB10-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB11-1", "uniprot_id": [ { "id": "TGFA1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB11", "type": "external" } ], "mass": 97006.0, "length": 859, "protein_name": "Transforming growth factor-beta receptor-associated protein 1", "gene_name": "TGFBRAP1", "organism": "Bovine", "refseq_name": "transforming growth factor-beta receptor-associated protein 1", "refseq_ac": [ { "id": "NP_001095478", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095478", "type": "external" } ], "gene_names_uniprotkb": "TGFBRAP1", "gene_names_refseq": "TGFBRAP1; TRAP-1; TRAP1", "protein_names_uniprotkb": "Transforming growth factor-beta receptor-associated protein 1; TGF-beta receptor-associated protein 1; TRAP-1; TRAP1", "protein_names_refseq": "TGF-beta receptor-associated protein 1; transforming growth factor-beta receptor-associated protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:514660)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. May recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2 (By similarity)., [UniProtKB, UniProtKB]; Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes and in degradative but not recycling trafficking of endocytosed cargo (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005769 early endosome;GO:0016020 membrane;GO:0033263 CORVET complex", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0034058 endosomal vesicle fusion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB11-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB12-1", "uniprot_id": [ { "id": "UTP15_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB12", "type": "external" } ], "mass": 58495.0, "length": 519, "protein_name": "U3 small nucleolar RNA-associated protein 15 homolog", "gene_name": "UTP15", "organism": "Bovine", "refseq_name": "U3 small nucleolar RNA-associated protein 15 homolog", "refseq_ac": [ { "id": "NP_001094598", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094598", "type": "external" } ], "gene_names_uniprotkb": "UTP15", "gene_names_refseq": "UTP15", "protein_names_uniprotkb": "U3 small nucleolar RNA-associated protein 15 homolog", "protein_names_refseq": "U3 small nucleolar RNA-associated protein 15 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:526343); (R-BTA-6791226)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ribosome biogenesis factor. Involved in nucleolar processing of pre-18S ribosomal RNA. Required for optimal pre-ribosomal RNA transcription by RNA polymerase I. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0032040 small-subunit processome", "go_biological_process": "GO:2000234 positive regulation of rRNA processing;GO:0006351 DNA-templated transcription;GO:0006364 rRNA processing;GO:0045943 positive regulation of transcription by RNA polymerase I;GO:0042274 ribosomal small subunit biogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB12-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB46-1", "uniprot_id": [ { "id": "PCD18_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB46", "type": "external" } ], "mass": 125864.0, "length": 1134, "protein_name": "Protocadherin-18", "gene_name": "PCDH18", "organism": "Bovine", "refseq_name": "protocadherin-18 precursor", "refseq_ac": [ { "id": "NP_001095699", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095699", "type": "external" } ], "gene_names_uniprotkb": "PCDH18", "gene_names_refseq": "PCDH18", "protein_names_uniprotkb": "Protocadherin-18", "protein_names_refseq": "Protocadherin-18; protocadherin-18 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:539464)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Potential calcium-dependent cell-adhesion protein., [UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007420 brain development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB46-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB64-1", "uniprot_id": [ { "id": "IPRI_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB64", "type": "external" } ], "mass": 63432.0, "length": 556, "protein_name": "Inositol 1,4,5-trisphosphate receptor-interacting protein", "gene_name": "ITPRIP", "organism": "Bovine", "refseq_name": "inositol 1,4,5-trisphosphate receptor-interacting protein precursor", "refseq_ac": [ { "id": "NP_001094648", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094648", "type": "external" } ], "gene_names_uniprotkb": "ITPRIP", "gene_names_refseq": "ITPRIP", "protein_names_uniprotkb": "Inositol 1,4,5-trisphosphate receptor-interacting protein", "protein_names_refseq": "inositol 1,4,5-triphosphate receptor-interacting protein; inositol 1,4,5-trisphosphate receptor-interacting protein precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:538685)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004860 protein kinase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0005640 nuclear outer membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB64-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB71-1", "uniprot_id": [ { "id": "AT1B4_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB71", "type": "external" } ], "mass": 41473.0, "length": 355, "protein_name": "Protein ATP1B4", "gene_name": "ATP1B4", "organism": "Bovine", "refseq_name": "protein ATP1B4", "refseq_ac": [ { "id": "NP_001095389", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095389", "type": "external" } ], "gene_names_uniprotkb": "ATP1B4", "gene_names_refseq": "ATP1B4", "protein_names_uniprotkb": "Protein ATP1B4; X,K-ATPase subunit beta-m; X/potassium-transporting ATPase subunit beta-m", "protein_names_refseq": "ATPase, (Na+)/K+ transporting, beta 4 polypeptide; protein ATP1B4; putative testis-expressed protein 13C; x,K-ATPase subunit beta-m; x/potassium-transporting ATPase subunit beta-m", "tax_id": 9913, "disease": "", "pathway": " (bta:510026); (R-BTA-2173795)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005637 nuclear inner membrane;GO:0005890 sodium:potassium-exchanging ATPase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006813 potassium ion transport;GO:0006814 sodium ion transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MB71-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MB78-1", "uniprot_id": [ { "id": "GYS1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MB78", "type": "external" } ], "mass": 83814.0, "length": 736, "protein_name": "Glycogen [starch] synthase, muscle", "gene_name": "GYS1", "organism": "Bovine", "refseq_name": "glycogen [starch] synthase, muscle", "refseq_ac": [ { "id": "NP_001094769", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094769", "type": "external" } ], "gene_names_uniprotkb": "GYS1", "gene_names_refseq": "GYS1", "protein_names_uniprotkb": "Glycogen [starch] synthase, muscle; 2.4.1.11; Glycogen synthase 1", "protein_names_refseq": "glycogen [starch] synthase, muscle", "tax_id": 9913, "disease": "", "pathway": " (bta:786335); (R-BTA-3322077)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "29541418", "class_list": "glycogene;glycosyltransferase", "function": "Glycogen synthase participates in the glycogen biosynthetic process along with glycogenin and glycogen branching enzyme. Extends the primer composed of a few glucose units formed by glycogenin by adding new glucose units to it. In this context, glycogen synthase transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.18", "type": "external" }, { "id": "2.4.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.11", "type": "external" } ], "go_molecular_function": "GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0005978 glycogen biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7MB78-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.11000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBB8-1", "uniprot_id": [ { "id": "DOK2_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MBB8", "type": "external" } ], "mass": 45729.0, "length": 413, "protein_name": "Docking protein 2", "gene_name": "DOK2", "organism": "Bovine", "refseq_name": "docking protein 2", "refseq_ac": [ { "id": "NP_001095472", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095472", "type": "external" } ], "gene_names_uniprotkb": "DOK2", "gene_names_refseq": "DOK2", "protein_names_uniprotkb": "Docking protein 2; Downstream of tyrosine kinase 2", "protein_names_refseq": "Downstream of tyrosine kinase 2; docking protein 2, 56kDa; docking protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:514616); (R-BTA-210993); (R-BTA-8853659)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity)., [UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007265 Ras protein signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBB8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBC0-1", "uniprot_id": [ { "id": "NAGA_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MBC0", "type": "external" } ], "mass": 43496.0, "length": 409, "protein_name": "N-acetylglucosamine-6-phosphate deacetylase", "gene_name": "AMDHD2", "organism": "Bovine", "refseq_name": "N-acetylglucosamine-6-phosphate deacetylase", "refseq_ac": [ { "id": "NP_001094574", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094574", "type": "external" } ], "gene_names_uniprotkb": "AMDHD2", "gene_names_refseq": "AMDHD2", "protein_names_uniprotkb": "N-acetylglucosamine-6-phosphate deacetylase; 3.5.1.25; Amidohydrolase domain-containing protein 2; GlcNAc 6-P deacetylase", "protein_names_refseq": "N-acetylglucosamine-6-phosphate deacetylase; amidohydrolase domain-containing protein 2; glcNAc 6-P deacetylase; putative N-acetylglucosamine-6-phosphate deacetylase", "tax_id": 9913, "disease": "", "pathway": " (bta:521401); (R-BTA-446210)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.25", "type": "external" } ], "go_molecular_function": "GO:0008448 N-acetylglucosamine-6-phosphate deacetylase activity;GO:0046872 metal ion binding", "go_cellular_component": "", "go_biological_process": "GO:0006046 N-acetylglucosamine catabolic process;GO:0019262 N-acetylneuraminate catabolic process;GO:0106279 negative regulation of UDP-N-acetylglucosamine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBC0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7MBE4-1", "uniprot_id": [ { "id": "MIOX_BOVIN", "url": "https://www.uniprot.org/uniprot/A7MBE4", "type": "external" } ], "mass": 32973.0, "length": 285, "protein_name": "Inositol oxygenase", "gene_name": "MIOX", "organism": "Bovine", "refseq_name": "inositol oxygenase", "refseq_ac": [ { "id": "NP_001094535", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094535", "type": "external" } ], "gene_names_uniprotkb": "MIOX", "gene_names_refseq": "MIOX", "protein_names_uniprotkb": "Inositol oxygenase; 1.13.99.1; MI oxygenase; Myo-inositol oxygenase", "protein_names_refseq": "MI oxygenase; inositol oxygenase", "tax_id": 9913, "disease": "", "pathway": " (bta:508591); (R-BTA-1855183)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.99.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.99.1", "type": "external" } ], "go_molecular_function": "GO:0008199 ferric iron binding;GO:0050113 inositol oxygenase activity;GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H;GO:0005506 iron ion binding", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019310 inositol catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7MBE4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7XYH9-1", "uniprot_id": [ { "id": "SOBP_BOVIN", "url": "https://www.uniprot.org/uniprot/A7XYH9", "type": "external" } ], "mass": 92469.0, "length": 872, "protein_name": "Sine oculis-binding protein homolog", "gene_name": "SOBP", "organism": "Bovine", "refseq_name": "sine oculis-binding protein homolog", "refseq_ac": [ { "id": "NP_001094640", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094640", "type": "external" } ], "gene_names_uniprotkb": "SOBP; JXC1", "gene_names_refseq": "JXC1; SOBP", "protein_names_uniprotkb": "Sine oculis-binding protein homolog; Jackson circler protein 1", "protein_names_refseq": "jackson circler protein 1; sine oculis-binding protein homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:537433)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Implicated in development of the cochlea., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 2, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0042472 inner ear morphogenesis;GO:0048513 animal organ development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7XYH9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YW98-1", "uniprot_id": [ { "id": "SYRC_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YW98", "type": "external" } ], "mass": 75561.0, "length": 660, "protein_name": "Arginine--tRNA ligase, cytoplasmic", "gene_name": "RARS1", "organism": "Bovine", "refseq_name": "arginine--tRNA ligase, cytoplasmic", "refseq_ac": [ { "id": "NP_001098808", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098808", "type": "external" } ], "gene_names_uniprotkb": "RARS1; RARS", "gene_names_refseq": "ArgRS; RARS1; RARS", "protein_names_uniprotkb": "Arginine--tRNA ligase, cytoplasmic; 6.1.1.19; ArgRS; Arginyl-tRNA synthetase", "protein_names_refseq": "arginine--tRNA ligase, cytoplasmic; arginyl-tRNA synthetase, cytoplasmic", "tax_id": 9913, "disease": "", "pathway": " (bta:506305); (R-BTA-9856649)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.4", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004814 arginine-tRNA ligase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex", "go_biological_process": "GO:0006420 arginyl-tRNA aminoacylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YW98-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YWG4-1", "uniprot_id": [ { "id": "GGH_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YWG4", "type": "external" } ], "mass": 35683.0, "length": 318, "protein_name": "Gamma-glutamyl hydrolase", "gene_name": "GGH", "organism": "Bovine", "refseq_name": "gamma-glutamyl hydrolase precursor", "refseq_ac": [ { "id": "NP_001098864", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098864", "type": "external" } ], "gene_names_uniprotkb": "GGH", "gene_names_refseq": "GGH", "protein_names_uniprotkb": "Gamma-glutamyl hydrolase; 3.4.19.9; Conjugase; GH; Gamma-Glu-X carboxypeptidase", "protein_names_refseq": "GH; conjugase; gamma-Glu-X carboxypeptidase; gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); gamma-glutamyl hydrolase precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:525303); (R-BTA-6798695)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Exhibits either endo- or exopeptidase activity depending upon the tissue of origin. When secreted, it acts primarily as an endopeptidase (By similarity)., [UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 4, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.42", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.42", "type": "external" }, { "id": "5.3.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1", "type": "external" }, { "id": "3.2.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.23", "type": "external" }, { "id": "4.1.2.13", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13", "type": "external" }, { "id": "3.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.6.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.4", "type": "external" }, { "id": "3.1.6.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "3.2.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18", "type": "external" }, { "id": "3.4.19.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9", "type": "external" }, { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.5.1.26", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.26", "type": "external" }, { "id": "3.5.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3", "type": "external" }, { "id": "3.4.23.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "1.6.5.5", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5", "type": "external" }, { "id": "3.5.4.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4", "type": "external" }, { "id": "3.2.1.166", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166", "type": "external" }, { "id": "3.2.1.51", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.2.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.52", "type": "external" }, { "id": "1.16.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1", "type": "external" }, { "id": "1.11.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27", "type": "external" }, { "id": "3.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4", "type": "external" }, { "id": "2.3.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23", "type": "external" }, { "id": "3.4.18.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1", "type": "external" }, { "id": "1.6.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2", "type": "external" }, { "id": "3.4.21.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-", "type": "external" }, { "id": "3.4.22.27", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "3.4.24.35", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35", "type": "external" }, { "id": "3.2.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17", "type": "external" }, { "id": "3.1.6.8", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.6.8", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.2.1.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24", "type": "external" }, { "id": "3.5.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.1", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "3.4.16.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.5", "type": "external" }, { "id": "3.4.16.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.-", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": "3.4.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.4", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" } ], "go_molecular_function": "GO:0034722 gamma-glutamyl-peptidase activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:0042470 melanosome;GO:0005773 vacuole", "go_biological_process": "GO:0046900 tetrahydrofolylpolyglutamate metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YWG4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YWH9-1", "uniprot_id": [ { "id": "RHDF1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YWH9", "type": "external" } ], "mass": 97270.0, "length": 856, "protein_name": "Inactive rhomboid protein 1", "gene_name": "RHBDF1", "organism": "Bovine", "refseq_name": "inactive rhomboid protein 1", "refseq_ac": [ { "id": "NP_001098870", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098870", "type": "external" } ], "gene_names_uniprotkb": "RHBDF1", "gene_names_refseq": "RHBDF1", "protein_names_uniprotkb": "Inactive rhomboid protein 1; Rhomboid family member 1; iRhom1", "protein_names_refseq": "Rhomboid family member 1; iRhom1; inactive rhomboid protein 1; rhomboid family 1", "tax_id": 9913, "disease": "", "pathway": " (bta:529167)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "30573663", "class_list": "", "function": "Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019838 growth factor binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0008283 cell population proliferation;GO:0015031 protein transport;GO:0016477 cell migration;GO:0050708 regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7YWH9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000011001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YWM2-1", "uniprot_id": [ { "id": "K1C40_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YWM2", "type": "external" } ], "mass": 47820.0, "length": 431, "protein_name": "Keratin, type I cytoskeletal 40", "gene_name": "KRT40", "organism": "Bovine", "refseq_name": "keratin, type I cytoskeletal 40", "refseq_ac": [ { "id": "NP_001098888", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098888", "type": "external" } ], "gene_names_uniprotkb": "KRT40", "gene_names_refseq": "KRT40", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 40; CK-40; Cytokeratin-40; K40; Keratin-40", "protein_names_refseq": "CK-40; K40; cytokeratin-40; keratin, type I cytoskeletal 40", "tax_id": 9913, "disease": "", "pathway": " (bta:538611); (R-BTA-6805567); (R-BTA-6809371)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in late hair differentiation., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0045095 keratin filament", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YWM2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YWP2-1", "uniprot_id": [ { "id": "PGAP3_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YWP2", "type": "external" } ], "mass": 36056.0, "length": 319, "protein_name": "GPI-specific phospholipase A2-like PGAP3", "gene_name": "PGAP3", "organism": "Bovine", "refseq_name": "GPI-specific phospholipase A2-like PGAP3 precursor", "refseq_ac": [ { "id": "NP_001098833", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098833", "type": "external" } ], "gene_names_uniprotkb": "PGAP3; PERLD1", "gene_names_refseq": "PERLD1; PGAP3", "protein_names_uniprotkb": "GPI-specific phospholipase A2-like PGAP3; 3.1.1.-; PER1-like domain-containing protein 1; Post-GPI attachment to proteins factor 3", "protein_names_refseq": "GPI-specific phospholipase A2-like PGAP3 precursor; GPI-specific phospholipase A2-like PGAP3; PER1-like domain-containing protein 1; per1-like domain containing 1; post-GPI attachment to proteins 3; post-GPI attachment to proteins factor 3", "tax_id": 9913, "disease": "", "pathway": " (bta:513258)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the fatty acid remodeling steps of GPI-anchor maturation where the unsaturated acyl chain at sn-2 of inositol phosphate is replaced by a saturated stearoyl chain. May catalyze the first step of the fatty acid remodeling, by removing the unsaturated acyl chain at sn-2 of inositol phosphate, generating a lyso-GPI intermediate. The fatty acid remodeling steps is critical for the integration of GPI-APs into lipid rafts., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 1, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0016788 hydrolase activity, acting on ester bonds", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006505 GPI anchor metabolic process;GO:0006506 GPI anchor biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YWP2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YWP4-1", "uniprot_id": [ { "id": "HUTH_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YWP4", "type": "external" } ], "mass": 72291.0, "length": 657, "protein_name": "Histidine ammonia-lyase", "gene_name": "HAL", "organism": "Bovine", "refseq_name": "histidine ammonia-lyase", "refseq_ac": [ { "id": "NP_001098910", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098910", "type": "external" } ], "gene_names_uniprotkb": "HAL", "gene_names_refseq": "HAL", "protein_names_uniprotkb": "Histidine ammonia-lyase; 4.3.1.3; Histidase", "protein_names_refseq": "histidase; histidine ammonia-lyase", "tax_id": 9913, "disease": "", "pathway": " (bta:615205); (R-BTA-70921)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "25421803", "class_list": "", "function": "SNPs within the HAL gene are associated with milk production traits in Chinese Holstein cows. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 4, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.3.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:4.3.1.3", "type": "external" } ], "go_molecular_function": "GO:0004397 histidine ammonia-lyase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0019556 L-histidine catabolic process to glutamate and formamide;GO:0019557 L-histidine catabolic process to glutamate and formate;GO:0006548 L-histidine catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7YWP4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YY54-1", "uniprot_id": [ { "id": "JUND_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YY54", "type": "external" } ], "mass": 35352.0, "length": 347, "protein_name": "Transcription factor JunD", "gene_name": "JUND", "organism": "Bovine", "refseq_name": "transcription factor JunD", "refseq_ac": [ { "id": "NP_001096723", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096723", "type": "external" } ], "gene_names_uniprotkb": "JUND", "gene_names_refseq": "JUND", "protein_names_uniprotkb": "Transcription factor JunD; Transcription factor AP-1 subunit JunD", "protein_names_refseq": "jun D proto-oncogene; transcription factor AP-1 subunit JunD; transcription factor JunD; transcription factor jun-D", "tax_id": 9913, "disease": "", "pathway": " (bta:517192)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "18368600", "class_list": "", "function": "The present data indicate that bovine dialyzable leukocyte extract can block the AP-1 DNA-binding activity and expression of several transcriptions factors in breast cancer cells., [RefSeq, PubMed]; Transcription factor binding AP-1 sites (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (By similarity)., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048545 response to steroid hormone;GO:0051726 regulation of cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A7YY54-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YY57-1", "uniprot_id": [ { "id": "RHG29_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YY57", "type": "external" } ], "mass": 142971.0, "length": 1269, "protein_name": "Rho GTPase-activating protein 29", "gene_name": "ARHGAP29", "organism": "Bovine", "refseq_name": "rho GTPase-activating protein 29", "refseq_ac": [ { "id": "NP_001095955", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095955", "type": "external" } ], "gene_names_uniprotkb": "ARHGAP29", "gene_names_refseq": "ARHGAP29", "protein_names_uniprotkb": "Rho GTPase-activating protein 29; Rho-type GTPase-activating protein 29", "protein_names_refseq": "rho GTPase-activating protein 29; rho-type GTPase-activating protein 29", "tax_id": 9913, "disease": "", "pathway": " (bta:504657); (R-BTA-8980692); (R-BTA-9013148)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis (By similarity)., [UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 12, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0007165 signal transduction;GO:0051058 negative regulation of small GTPase mediated signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YY57-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YY62-1", "uniprot_id": [ { "id": "FHI1B_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YY62", "type": "external" } ], "mass": 105488.0, "length": 973, "protein_name": "FHF complex subunit HOOK-interacting protein 1B", "gene_name": "FHIP1B", "organism": "Bovine", "refseq_name": "FHF complex subunit HOOK-interacting protein 1B", "refseq_ac": [ { "id": "NP_001095961", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095961", "type": "external" } ], "gene_names_uniprotkb": "FHIP1B; FAM160A2", "gene_names_refseq": "FAM160A2; FHIP1B; FHIP", "protein_names_uniprotkb": "FHF complex subunit HOOK-interacting protein 1B; FHIP1B; FHIP; FTS- and Hook-interacting protein", "protein_names_refseq": "FHF complex subunit HOOK-interacting protein 1B; FTS and Hook-interacting protein; family with sequence similarity 160 member A2", "tax_id": 9913, "disease": "", "pathway": " (bta:508334)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 7, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0070695 FHF complex", "go_biological_process": "GO:0015031 protein transport;GO:0007032 endosome organization;GO:0007040 lysosome organization;GO:0008333 endosome to lysosome transport;GO:0045022 early endosome to late endosome transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YY62-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7YY73-1", "uniprot_id": [ { "id": "MAFF_BOVIN", "url": "https://www.uniprot.org/uniprot/A7YY73", "type": "external" } ], "mass": 18231.0, "length": 172, "protein_name": "Transcription factor MafF", "gene_name": "MAFF", "organism": "Bovine", "refseq_name": "transcription factor MafF", "refseq_ac": [ { "id": "NP_001096770", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096770", "type": "external" } ], "gene_names_uniprotkb": "MAFF", "gene_names_refseq": "MAFF", "protein_names_uniprotkb": "Transcription factor MafF; V-maf musculoaponeurotic fibrosarcoma oncogene homolog F", "protein_names_refseq": "transcription factor MafF", "tax_id": 9913, "disease": "", "pathway": " (bta:617914); (R-BTA-983231)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm", "go_biological_process": "GO:0045604 regulation of epidermal cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7YY73-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7Z017-1", "uniprot_id": [ { "id": "MAF_BOVIN", "url": "https://www.uniprot.org/uniprot/A7Z017", "type": "external" } ], "mass": 38987.0, "length": 377, "protein_name": "Transcription factor Maf", "gene_name": "MAF", "organism": "Bovine", "refseq_name": "transcription factor Maf", "refseq_ac": [ { "id": "NP_001099107", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099107", "type": "external" } ], "gene_names_uniprotkb": "MAF", "gene_names_refseq": "C-Maf; MAF", "protein_names_uniprotkb": "Transcription factor Maf; Proto-oncogene c-Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog", "protein_names_refseq": "Proto-oncogene c-maf; transcription factor Maf", "tax_id": 9913, "disease": "", "pathway": " (bta:782481)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T-helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding (By similarity)., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0070306 lens fiber cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7Z017-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7Z061-1", "uniprot_id": [ { "id": "CDC27_BOVIN", "url": "https://www.uniprot.org/uniprot/A7Z061", "type": "external" } ], "mass": 91870.0, "length": 825, "protein_name": "Cell division cycle protein 27 homolog", "gene_name": "CDC27", "organism": "Bovine", "refseq_name": "cell division cycle protein 27 homolog", "refseq_ac": [ { "id": "NP_001098898", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098898", "type": "external" } ], "gene_names_uniprotkb": "CDC27", "gene_names_refseq": "CDC27", "protein_names_uniprotkb": "Cell division cycle protein 27 homolog", "protein_names_refseq": "cell division cycle 27 homolog; cell division cycle protein 27 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:540660); (R-BTA-141430); (R-BTA-174048); (R-BTA-174084); (R-BTA-174154); (R-BTA-174178); (R-BTA-174184); (R-BTA-176407); (R-BTA-176408); (R-BTA-176409); (R-BTA-176412); (R-BTA-179409); (R-BTA-2467813); (R-BTA-2559582); (R-BTA-68867); (R-BTA-69017); (R-BTA-983168)", "pathway_count": 17, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 15, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0140767 enzyme-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005680 anaphase-promoting complex", "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination;GO:0031145 anaphase-promoting complex-dependent catabolic process;GO:0070979 protein K11-linked ubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7Z061-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A7Z070-1", "uniprot_id": [ { "id": "TMG1_BOVIN", "url": "https://www.uniprot.org/uniprot/A7Z070", "type": "external" } ], "mass": 25045.0, "length": 218, "protein_name": "Transmembrane gamma-carboxyglutamic acid protein 1", "gene_name": "PRRG1", "organism": "Bovine", "refseq_name": "transmembrane gamma-carboxyglutamic acid protein 1", "refseq_ac": [ { "id": "NP_001099110", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099110", "type": "external" } ], "gene_names_uniprotkb": "PRRG1; TMG1", "gene_names_refseq": "PRRG1; TMG1", "protein_names_uniprotkb": "Transmembrane gamma-carboxyglutamic acid protein 1; Proline-rich Gla protein 1; Proline-rich gamma-carboxyglutamic acid protein 1", "protein_names_refseq": "Proline-rich Gla protein 1; Proline-rich gamma-carboxyglutamic acid protein 1; proline rich Gla (G-carboxyglutamic acid) 1; transmembrane gamma-carboxyglutamic acid protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:785916)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006508 proteolysis;GO:0007596 blood coagulation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A7Z070-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8E4L1-1", "uniprot_id": [ { "id": "COX19_BOVIN", "url": "https://www.uniprot.org/uniprot/A8E4L1", "type": "external" } ], "mass": 10319.0, "length": 89, "protein_name": "Cytochrome c oxidase assembly protein COX19", "gene_name": "COX19", "organism": "Bovine", "refseq_name": "cytochrome c oxidase assembly protein COX19", "refseq_ac": [ { "id": "NP_001103436", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103436", "type": "external" } ], "gene_names_uniprotkb": "COX19", "gene_names_refseq": "COX19", "protein_names_uniprotkb": "Cytochrome c oxidase assembly protein COX19", "protein_names_refseq": "COX19 cytochrome c oxidase assembly homolog; COX19, cytochrome c oxidase assembly factor; cytochrome c oxidase assembly protein COX19", "tax_id": 9913, "disease": "", "pathway": " (bta:100126182); (R-BTA-9864848)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Assembly factor for cytochrome c oxidase (respiratory chain complex IV, CIV). Acts as a COX11 chaperone that supports COX11 copper coordination. Also stimulates SCO2-mediated metalation of COX2. Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis. In the absence of COX11, capable of stimulating copper delivery to the copper B site of COX1., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044183 protein folding chaperone", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005758 mitochondrial intermembrane space;GO:0005829 cytosol", "go_biological_process": "GO:0006878 intracellular copper ion homeostasis;GO:0033617 mitochondrial respiratory chain complex IV assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8E4L1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A8E4M4-1", "uniprot_id": [ { "id": "MCRI1_BOVIN", "url": "https://www.uniprot.org/uniprot/A8E4M4", "type": "external" } ], "mass": 11137.0, "length": 97, "protein_name": "Mapk-regulated corepressor-interacting protein 1", "gene_name": "MCRIP1", "organism": "Bovine", "refseq_name": "mapk-regulated corepressor-interacting protein 1", "refseq_ac": [ { "id": "NP_001103264", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103264", "type": "external" } ], "gene_names_uniprotkb": "MCRIP1; FAM195B", "gene_names_refseq": "FAM195B; MCRIP1", "protein_names_uniprotkb": "Mapk-regulated corepressor-interacting protein 1; Protein FAM195B", "protein_names_refseq": "family with sequence similarity 195, member B; mapk-regulated corepressor-interacting protein 1; protein FAM195B", "tax_id": 9913, "disease": "", "pathway": " (bta:512391)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 3, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0010494 cytoplasmic stress granule", "go_biological_process": "GO:0010717 regulation of epithelial to mesenchymal transition", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "A8E4M4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "A9QWQ1-1", "uniprot_id": [ { "id": "CXL11_BOVIN", "url": "https://www.uniprot.org/uniprot/A9QWQ1", "type": "external" } ], "mass": 10943.0, "length": 100, "protein_name": "C-X-C motif chemokine 11", "gene_name": "CXCL11", "organism": "Bovine", "refseq_name": "C-X-C motif chemokine 11 precursor", "refseq_ac": [ { "id": "NP_001106644", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106644", "type": "external" } ], "gene_names_uniprotkb": "CXCL11", "gene_names_refseq": "CXCL11", "protein_names_uniprotkb": "C-X-C motif chemokine 11; Small-inducible cytokine B11", "protein_names_refseq": "C-X-C motif chemokine 11 precursor; C-X-C motif chemokine 11; I-TAC; small-inducible cytokine B11", "tax_id": 9913, "disease": "", "pathway": " (bta:516104); (R-BTA-380108); (R-BTA-418594)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "20347492", "class_list": "", "function": "Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses (By similarity)., [UniProtKB]; Cloning and characterization of expressed gene sequences of the interferon-gamma inducible chemokine CXCL11, or I-TAC, associated with type 1 T-helper immune responses, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008201 heparin binding;GO:0008009 chemokine activity;GO:0048248 CXCR3 chemokine receptor binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0042127 regulation of cell population proliferation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "A9QWQ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "B4XF06-1", "uniprot_id": [ { "id": "GPR39_BOVIN", "url": "https://www.uniprot.org/uniprot/B4XF06", "type": "external" } ], "mass": 51445.0, "length": 454, "protein_name": "G protein-coupled receptor 39", "gene_name": "GPR39", "organism": "Bovine", "refseq_name": "G-protein coupled receptor 39", "refseq_ac": [ { "id": "NP_001137216", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137216", "type": "external" } ], "gene_names_uniprotkb": "GPR39", "gene_names_refseq": "GPR39", "protein_names_uniprotkb": "G protein-coupled receptor 39", "protein_names_refseq": "G-protein coupled receptor 39; orphan G-protein coupled receptor 39", "tax_id": 9913, "disease": "", "pathway": " (bta:100139476)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19498292", "class_list": "", "function": "Zinc-sensing receptor that can sense changes in extracellular Zn(2+), mediate Zn(2+) signal transmission, and participates in the regulation of numerous physiological processes including glucose homeostasis regulation, gastrointestinal mobility, hormone secretion and cell death. Activation by Zn(2+) in keratinocytes increases the intracellular concentration of Ca(2+) and activates the ERK/MAPK and PI3K/AKT signaling pathways leading to epithelial repair (By similarity). Plays an essential role in normal wound healing by inducing the production of cytokines including the major inflammatory cytokine IL6 via the PKC/MAPK/CEBPB pathway (By similarity). Regulates adipose tissue metabolism, especially lipolysis, and regulates the function of lipases, such as hormone-sensitive lipase and adipose triglyceride lipase (By similarity). Plays a role in the inhibition of cell death and protects against oxidative, endoplasmic reticulum and mitochondrial stress by inducing secretion of the cytoprotective pigment epithelium-derived growth factor (PEDF) and probably other protective transcripts in a GNA13/RHOA/SRE-dependent manner. Forms dynamic heteroreceptor complexes with HTR1A and GALR1 depending on cell type or specific physiological states, resulting in signaling diversity: HTR1A-GPR39 shows additive increase in signaling along the serum response element (SRE) and NF-kappa-B pathways while GALR1 acts as an antagonist blocking SRE (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 3, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "B4XF06-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000010001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B710-1", "uniprot_id": [ { "id": "E1B710_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B710", "type": "external" } ], "mass": 34422.0, "length": 330, "protein_name": "Homeobox protein Nkx-3.2", "gene_name": "NKX3-2", "organism": "Bovine", "refseq_name": "homeobox protein Nkx-3.2", "refseq_ac": [ { "id": "NP_001180062", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180062", "type": "external" } ], "gene_names_uniprotkb": "NKX3-2", "gene_names_refseq": "NKX3-2", "protein_names_uniprotkb": "Homeobox protein Nkx-3.2; Bagpipe homeobox protein homolog 1; Homeobox protein NK-3 homolog B", "protein_names_refseq": "homeobox protein Nkx-3.2", "tax_id": 9913, "disease": "", "pathway": " (bta:616907)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0001501 skeletal system development;GO:0032331 negative regulation of chondrocyte differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B710-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B742-1", "uniprot_id": [ { "id": "E1B742_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B742", "type": "external" } ], "mass": 50497.0, "length": 461, "protein_name": "P2X purinoceptor", "gene_name": "P2RX6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "P2RX6", "gene_names_refseq": "", "protein_names_uniprotkb": "P2X purinoceptor; P2X purinoceptor 6", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-139853); (R-BTA-418346)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a modulatory subunit rather than a functional channel., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 1, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0001614 purinergic nucleotide receptor activity;GO:0004931 extracellularly ATP-gated monoatomic cation channel activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0043025 neuronal cell body;GO:0098794 postsynapse", "go_biological_process": "GO:0070588 calcium ion transmembrane transport;GO:0033198 response to ATP", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B742-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7B4-1", "uniprot_id": [ { "id": "E1B7B4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7B4", "type": "external" } ], "mass": 79676.0, "length": 700, "protein_name": "Meprin A subunit", "gene_name": "MEP1B", "organism": "Bovine", "refseq_name": "meprin A subunit beta precursor", "refseq_ac": [ { "id": "NP_001137570", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137570", "type": "external" } ], "gene_names_uniprotkb": "MEP1B", "gene_names_refseq": "MEP1B", "protein_names_uniprotkb": "Meprin A subunit; 3.4.24.-; Endopeptidase-2", "protein_names_refseq": "N-benzoyl-L-tyrosyl-p-amino-benzoic acid hydrolase beta; meprin A subunit beta precursor; meprin A, beta", "tax_id": 9913, "disease": "", "pathway": " (bta:540701)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0017090 meprin A complex", "go_biological_process": "GO:0006508 proteolysis;GO:0006954 inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7B4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7E8-1", "uniprot_id": [ { "id": "E1B7E8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7E8", "type": "external" } ], "mass": 21564.0, "length": 189, "protein_name": "Uncharacterized protein", "gene_name": "LOC132345931", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "LOC132345931", "gene_names_refseq": "", "protein_names_uniprotkb": "Uncharacterized protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-909733); (R-BTA-912694)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "E1BMS1", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0005132 type I interferon receptor binding", "go_cellular_component": "GO:0005615 extracellular space", "go_biological_process": "GO:0002312 B cell activation involved in immune response;GO:0051607 defense response to virus;GO:0060337 type I interferon-mediated signaling pathway;GO:0002250 adaptive immune response;GO:0043330 response to exogenous dsRNA", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7E8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7F6-1", "uniprot_id": [ { "id": "E1B7F6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7F6", "type": "external" } ], "mass": 232636.0, "length": 2139, "protein_name": "Plexin-B1", "gene_name": "PLXNB1", "organism": "Bovine", "refseq_name": "plexin-B1 isoform X1", "refseq_ac": [ { "id": "XP_024839045", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024839045", "type": "external" } ], "gene_names_uniprotkb": "PLXNB1", "gene_names_refseq": "PLXNB1", "protein_names_uniprotkb": "Plexin-B1", "protein_names_refseq": "plexin-B1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:616798); (R-BTA-416482); (R-BTA-416550); (R-BTA-416572)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0032794 GTPase activating protein binding;GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane", "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0007162 negative regulation of cell adhesion;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0071526 semaphorin-plexin signaling pathway;GO:0048812 neuron projection morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7F6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7G3-1", "uniprot_id": [ { "id": "E1B7G3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7G3", "type": "external" } ], "mass": 64594.0, "length": 592, "protein_name": "E3 ubiquitin-protein ligase CHIP", "gene_name": "STUB1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "STUB1", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase CHIP; 2.3.2.27; Carboxy terminus of Hsp70-interacting protein; RING-type E3 ubiquitin transferase CHIP; STIP1 homology and U box-containing protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2173788); (R-BTA-5357905); (R-BTA-5675482); (R-BTA-8863795); (R-BTA-8939902); (R-BTA-8948751); (R-BTA-983168)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" } ], "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0030018 Z disc", "go_biological_process": "GO:0006281 DNA repair;GO:0007165 signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination;GO:0045862 positive regulation of proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7G3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7H0-1", "uniprot_id": [ { "id": "E1B7H0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7H0", "type": "external" } ], "mass": 35008.0, "length": 325, "protein_name": "Forkhead box B1", "gene_name": "FOXB1", "organism": "Bovine", "refseq_name": "forkhead box protein B1", "refseq_ac": [ { "id": "XP_059746822", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059746822", "type": "external" } ], "gene_names_uniprotkb": "FOXB1", "gene_names_refseq": "FOXB1", "protein_names_uniprotkb": "Forkhead box B1", "protein_names_refseq": "forkhead box protein B1", "tax_id": 9913, "disease": "", "pathway": " (bta:539181)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008542 visual learning;GO:0021510 spinal cord development;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7H0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7I9-1", "uniprot_id": [ { "id": "E1B7I9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7I9", "type": "external" } ], "mass": 57159.0, "length": 508, "protein_name": "Fibroblast growth factor receptor substrate 2", "gene_name": "FRS2", "organism": "Bovine", "refseq_name": "fibroblast growth factor receptor substrate 2", "refseq_ac": [ { "id": "XP_002687431", "url": 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binding;GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity;GO:0005104 fibroblast growth factor receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction", "go_biological_process": "GO:2000726 negative regulation of cardiac muscle cell differentiation;GO:0008543 fibroblast growth factor receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7I9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7K6-1", "uniprot_id": [ { "id": "E1B7K6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7K6", "type": "external" } ], "mass": 63604.0, "length": 564, "protein_name": "Diacylglycerol kinase", "gene_name": "DGKE", "organism": "Bovine", "refseq_name": "diacylglycerol kinase epsilon", "refseq_ac": [ { "id": "NP_001179859", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179859", "type": "external" } ], "gene_names_uniprotkb": "DGKE", "gene_names_refseq": "DGKE", "protein_names_uniprotkb": "Diacylglycerol kinase; 2.7.1.107; DAG kinase", "protein_names_refseq": "diacylglycerol kinase epsilon; diacylglycerol kinase, epsilon 64kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:538147); (R-BTA-114508)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Membrane-bound diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids. Displays specificity for diacylglycerol substrates with an arachidonoyl acyl chain at the sn-2 position, with the highest activity toward 1-octadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol the main diacylglycerol intermediate within the phosphatidylinositol turnover cycle. Can also phosphorylate diacylglycerol substrates with a linoleoyl acyl chain at the sn-2 position but much less efficiently., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.107", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.107", "type": "external" }, { "id": "2.7.1.93", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.93", "type": "external" } ], "go_molecular_function": "GO:0004143 ATP-dependent diacylglycerol kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0046339 diacylglycerol metabolic process;GO:0046834 lipid phosphorylation;GO:0006654 phosphatidic acid biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7K6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7L9-1", "uniprot_id": [ { "id": "E1B7L9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7L9", "type": "external" } ], "mass": 100386.0, "length": 890, "protein_name": "Serine/threonine-protein kinase", "gene_name": "PRKD3", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase D3", "refseq_ac": [ { "id": "NP_001192467", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192467", "type": "external" } ], "gene_names_uniprotkb": "PRKD3", "gene_names_refseq": "PRKD3", "protein_names_uniprotkb": "Serine/threonine-protein kinase; 2.7.11.13", "protein_names_refseq": "serine/threonine-protein kinase D3", "tax_id": 9913, "disease": "", "pathway": " (bta:538447); (R-BTA-1660661)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0004697 diacylglycerol-dependent serine/threonine kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7L9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7M3-1", "uniprot_id": [ { "id": "E1B7M3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7M3", "type": "external" } ], "mass": 37366.0, "length": 338, "protein_name": "Mitoferrin-1", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitoferrin-1; Mitochondrial iron transporter 1; Solute carrier family 25 member 37", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015093 ferrous iron transmembrane transporter activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0046985 positive regulation of hemoglobin biosynthetic process;GO:0048250 iron import into the mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7M3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7M6-1", "uniprot_id": [ { "id": "E1B7M6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7M6", "type": "external" } ], "mass": 134331.0, "length": 1185, "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase", "gene_name": "PLCB2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PLCB2", "gene_names_refseq": "", "protein_names_uniprotkb": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; 3.1.4.11", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity;GO:0005509 calcium ion binding;GO:0120548 phosphatidylinositol phospholipase C activity", "go_cellular_component": "GO:0098992 neuronal dense core vesicle", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0016042 lipid catabolic process;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0060326 cell chemotaxis;GO:0046488 phosphatidylinositol metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7M6-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7Q1-1", "uniprot_id": [ { "id": "E1B7Q1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7Q1", "type": "external" } ], "mass": 31149.0, "length": 288, "protein_name": "Empty spiracles homeobox 1", "gene_name": "EMX1", "organism": "Bovine", "refseq_name": "homeobox protein EMX1", "refseq_ac": [ { "id": "NP_001179152", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179152", "type": "external" } ], "gene_names_uniprotkb": "EMX1", "gene_names_refseq": "EMX1", "protein_names_uniprotkb": "Empty spiracles homeobox 1", "protein_names_refseq": "homeobox protein EMX1", "tax_id": 9913, "disease": "", "pathway": " (bta:539333)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus", "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0007417 central nervous system development;GO:0007420 brain development;GO:0030182 neuron differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7Q1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7R0-1", "uniprot_id": [ { "id": "E1B7R0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7R0", "type": "external" } ], "mass": 99131.0, "length": 882, "protein_name": "DIS3-like exonuclease 2", "gene_name": "DIS3L2", "organism": "Bovine", "refseq_name": "DIS3-like exonuclease 2", "refseq_ac": [ { "id": "NP_001179435", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179435", "type": "external" } ], "gene_names_uniprotkb": "DIS3L2", "gene_names_refseq": "DIS3L2", "protein_names_uniprotkb": "DIS3-like exonuclease 2; 3.1.13.-", "protein_names_refseq": "DIS3 mitotic control homolog-like 2; DIS3-like exonuclease 2", "tax_id": 9913, "disease": "", "pathway": " (bta:519222)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0008266 poly(U) RNA binding", "go_cellular_component": "GO:0000932 P-body", "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0051301 cell division;GO:0019827 stem cell population maintenance;GO:0051306 mitotic sister chromatid separation;GO:0006402 mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7R0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7S6-1", "uniprot_id": [ { "id": "E1B7S6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7S6", "type": "external" } ], "mass": 69048.0, "length": 637, "protein_name": "Nuclear receptor subfamily 4 group A member 3", "gene_name": "NR4A3", "organism": "Bovine", "refseq_name": "nuclear receptor subfamily 4 group A member 3 isoform X3", "refseq_ac": [ { "id": "XP_005210270", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005210270", "type": "external" } ], "gene_names_uniprotkb": "NR4A3", "gene_names_refseq": "NR4A3", "protein_names_uniprotkb": "Nuclear receptor subfamily 4 group A member 3", "protein_names_refseq": "nuclear receptor subfamily 4 group A member 3 isoform X3", "tax_id": 9913, "disease": "", "pathway": " (bta:528877); (R-BTA-383280)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding;GO:0035259 nuclear glucocorticoid receptor binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0038097 positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0050728 negative regulation of inflammatory response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7S6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7W0-1", "uniprot_id": [ { "id": "E1B7W0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7W0", "type": "external" } ], "mass": 60362.0, "length": 567, "protein_name": "Alpha-1D adrenergic receptor", "gene_name": "ADRA1D", "organism": "Bovine", "refseq_name": "alpha-1D adrenergic receptor", "refseq_ac": [ { "id": "NP_001192613", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192613", "type": "external" } ], "gene_names_uniprotkb": "ADRA1D", "gene_names_refseq": "ADRA1D", "protein_names_uniprotkb": "Alpha-1D adrenergic receptor; Alpha-1D adrenoreceptor", "protein_names_refseq": "adrenergic, alpha-1D-, receptor; alpha-1D adrenergic receptor", "tax_id": 9913, "disease": "", "pathway": " (bta:539543); (R-BTA-390696); (R-BTA-416476); (R-BTA-416482)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1D binds the catecholamine ligands norepinephrine and epinephrine., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004937 alpha1-adrenergic receptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007204 positive regulation of cytosolic calcium ion concentration;GO:0007267 cell-cell signaling;GO:0043410 positive regulation of MAPK cascade;GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway;GO:0045907 positive regulation of vasoconstriction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7W0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B7X8-1", "uniprot_id": [ { "id": "E1B7X8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B7X8", "type": "external" } ], "mass": 46134.0, "length": 405, "protein_name": "S-adenosylmethionine sensor upstream of mTORC1", "gene_name": "BMT2", "organism": "Bovine", "refseq_name": "S-adenosylmethionine sensor upstream of mTORC1", "refseq_ac": [ { "id": "XP_002686845", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686845", "type": "external" } ], "gene_names_uniprotkb": "BMT2; SAMTOR", "gene_names_refseq": "BMT2", "protein_names_uniprotkb": "S-adenosylmethionine sensor upstream of mTORC1; 2.1.1.-; Probable methyltransferase BMT2 homolog", "protein_names_refseq": "S-adenosylmethionine sensor upstream of mTORC1", "tax_id": 9913, "disease": "", "pathway": " (bta:538658); (R-BTA-9639288)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase., [UniProtKB, HAMAP]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.1.2.2", "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.11.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-", "type": "external" } ], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0008168 methyltransferase activity;GO:1904047 S-adenosyl-L-methionine binding", "go_cellular_component": "", "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0032259 methylation;GO:0034198 cellular response to amino acid starvation;GO:0061431 cellular response to methionine", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B7X8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B827-1", "uniprot_id": [ { "id": "E1B827_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B827", "type": "external" } ], "mass": 75197.0, "length": 698, "protein_name": "Serine/threonine-protein kinase Nek8", "gene_name": "NEK8", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase Nek8", "refseq_ac": [ { "id": "NP_001179652", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179652", "type": "external" } ], "gene_names_uniprotkb": "NEK8", "gene_names_refseq": "NEK8", "protein_names_uniprotkb": 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"https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005813 centrosome;GO:0005929 cilium;GO:0005930 axoneme;GO:0097546 ciliary base;GO:0097543 ciliary inversin compartment", 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Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. 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The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). The BCR(KLHL12) complex is also involved in neural crest specification: in response to cytosolic calcium increase, interacts with the heterodimer formed with PEF1 and PDCD6/ALG-2, leading to bridge together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export. As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4 and PEF1, without leading to degradation of these proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0030134 COPII-coated ER to Golgi transport vesicle;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0030127 COPII vesicle coat", "go_biological_process": "GO:0014029 neural crest formation;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0014032 neural crest cell development;GO:0048208 COPII vesicle coating", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1B932-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B949-1", "uniprot_id": [ { "id": "E1B949_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B949", "type": "external" } ], "mass": 542233.0, "length": 4982, "protein_name": "Protocadherin Fat 4", "gene_name": "FAT4", "organism": "Bovine", "refseq_name": "protocadherin Fat 4 isoform X1", "refseq_ac": [ { "id": "XP_005217662", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005217662", "type": "external" } ], "gene_names_uniprotkb": "FAT4", "gene_names_refseq": "FAT4", "protein_names_uniprotkb": "Protocadherin Fat 4; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J", "protein_names_refseq": "protocadherin Fat 4 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:781683)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005509 calcium ion binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0045177 apical part of cell", "go_biological_process": "GO:0050793 regulation of developmental process;GO:0007409 axonogenesis;GO:0030855 epithelial cell differentiation;GO:0021987 cerebral cortex development;GO:0035329 hippo signaling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B949-1", "record_type": "protein", "filter_code": "0000000.0000001.000100.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B959-1", "uniprot_id": [ { "id": "E1B959_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B959", "type": "external" } ], "mass": 29995.0, "length": 259, "protein_name": "Phosphoglycerate mutase", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Phosphoglycerate mutase; 5.4.2.11; 5.4.2.4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.11) activity., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" } ], "go_molecular_function": "GO:0004082 bisphosphoglycerate mutase activity;GO:0004619 phosphoglycerate mutase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0006096 glycolytic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B959-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B988-1", "uniprot_id": [ { "id": "E1B988_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B988", "type": "external" } ], "mass": 54270.0, "length": 468, "protein_name": "GABA(C) receptor", "gene_name": "GABRR3", "organism": "Bovine", "refseq_name": "gamma-aminobutyric acid receptor subunit rho-3 precursor", "refseq_ac": [ { "id": "NP_001179448", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179448", "type": "external" } ], "gene_names_uniprotkb": "GABRR3", "gene_names_refseq": "GABRR3", "protein_names_uniprotkb": "GABA(C) receptor", "protein_names_refseq": "gamma-aminobutyric acid (GABA) receptor, rho 3; gamma-aminobutyric acid receptor subunit rho-3 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:520166); (R-BTA-977443)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0004890 GABA-A receptor activity;GO:0005230 extracellular ligand-gated monoatomic ion channel activity", "go_cellular_component": "GO:0098982 GABA-ergic synapse;GO:0045211 postsynaptic membrane;GO:0034707 chloride channel complex;GO:1902711 GABA-A receptor complex", "go_biological_process": "GO:1902476 chloride transmembrane transport;GO:0051932 synaptic transmission, GABAergic", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B988-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9B6-1", "uniprot_id": [ { "id": "E1B9B6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9B6", "type": "external" } ], "mass": 74092.0, "length": 662, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "NUAK1", "organism": "Bovine", "refseq_name": "NUAK family SNF1-like kinase 1", "refseq_ac": [ { "id": "NP_001192425", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192425", "type": "external" } ], "gene_names_uniprotkb": "NUAK1", "gene_names_refseq": "NUAK1", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "NUAK family SNF1-like kinase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:519892); (R-BTA-6804756)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0002039 p53 binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001650 fibrillar center", "go_biological_process": "GO:0030155 regulation of cell adhesion;GO:2000772 regulation of cellular senescence", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9B6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9D8-1", "uniprot_id": [ { "id": "CBPC3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9D8", "type": "external" } ], "mass": 116561.0, "length": 1003, "protein_name": "Cytosolic carboxypeptidase 3", "gene_name": "AGBL3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AGBL3; CCP3", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytosolic carboxypeptidase 3; 3.4.17.-; ATP/GTP-binding protein-like 3; Protein deglutamylase CCP3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Metallocarboxypeptidase that mediates deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. May catalyze the hydrolysis of aspartate from the carboxy-terminus of target proteins. Does not show detyrosinase or deglycylase activities from the carboxy-terminus of target proteins., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.17.24", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.24", "type": "external" }, { "id": "3.4.17.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.17.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004181 metallocarboxypeptidase activity;GO:0015631 tubulin binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0005814 centriole", "go_biological_process": "GO:0006508 proteolysis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9D8-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9E4-1", "uniprot_id": [ { "id": "E1B9E4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9E4", "type": "external" } ], "mass": 88804.0, "length": 791, "protein_name": "Diacylglycerol kinase", "gene_name": "DGKG", "organism": "Bovine", "refseq_name": "diacylglycerol kinase gamma isoform X1", "refseq_ac": [ { "id": "XP_002684915", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002684915", "type": "external" } ], "gene_names_uniprotkb": "DGKG", "gene_names_refseq": "DGKG", "protein_names_uniprotkb": "Diacylglycerol kinase; 2.7.1.107; DAG kinase", "protein_names_refseq": "diacylglycerol kinase gamma isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:518523); (R-BTA-114508)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Has no apparent specificity with regard to the acyl compositions of diacylglycerol. Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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biosynthetic process;GO:0035556 intracellular signal transduction;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9E4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9F9-1", "uniprot_id": [ { "id": "E1B9F9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9F9", "type": "external" } ], "mass": 110109.0, "length": 1015, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LATS2", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase LATS2 isoform X1", "refseq_ac": [ { "id": "XP_024855860", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024855860", "type": "external" } ], "gene_names_uniprotkb": "LATS2", "gene_names_refseq": "LATS2", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "serine/threonine-protein kinase LATS2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:508208); (R-BTA-2028269)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, 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}, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0043065 positive regulation of apoptotic process;GO:0051301 cell division;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:1900181 negative regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9F9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9H4-1", "uniprot_id": [ { "id": "E1B9H4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9H4", "type": "external" } ], "mass": 54093.0, "length": 493, "protein_name": "Extracellular tyrosine-protein kinase PKDCC", "gene_name": "PKDCC", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PKDCC", "gene_names_refseq": "", "protein_names_uniprotkb": "Extracellular tyrosine-protein kinase PKDCC; 2.7.10.2; Protein kinase domain-containing protein, cytoplasmic; Protein kinase-like protein SgK493; Sugen kinase 493; Vertebrate lonesome kinase", "protein_names_refseq": "", "tax_id": 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"go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0015031 protein transport;GO:0030154 cell differentiation;GO:0048286 lung alveolus development;GO:0001501 skeletal system development;GO:0048566 embryonic digestive tract development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9H4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9I8-1", "uniprot_id": [ { "id": "E1B9I8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9I8", "type": "external" } ], "mass": 61149.0, "length": 587, "protein_name": "Delta like canonical Notch ligand 3", "gene_name": "DLL3", "organism": "Bovine", "refseq_name": "delta-like protein 3 precursor", "refseq_ac": [ { "id": "NP_001179009", 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phosphatase binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005769 early endosome;GO:0005938 cell cortex;GO:0030054 cell junction;GO:0055037 recycling endosome", "go_biological_process": "GO:0042113 B cell activation;GO:0030888 regulation of B cell proliferation;GO:0050859 negative regulation of B cell receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9K4-1", "record_type": "protein", "filter_code": "0000000.0000000.000100.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9N9-1", "uniprot_id": [ { "id": "E1B9N9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9N9", "type": "external" } ], "mass": 39093.0, "length": 354, "protein_name": "Cellular communication network factor 6", "gene_name": "CCN6", "organism": "Bovine", "refseq_name": "cellular communication network factor 6 isoform X1", "refseq_ac": [ { "id": "XP_010806753", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010806753", "type": "external" } ], "gene_names_uniprotkb": "CCN6; WISP3", "gene_names_refseq": "CCN6", "protein_names_uniprotkb": "Cellular communication network factor 6; CCN family member 6; WNT1-inducible-signaling pathway protein 3", "protein_names_refseq": "cellular communication network factor 6 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:100849041)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0008083 growth factor activity", "go_cellular_component": "GO:0005615 extracellular space;GO:0005739 mitochondrion;GO:0031012 extracellular matrix", "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0051881 regulation of mitochondrial membrane potential;GO:0045597 positive regulation of cell differentiation;GO:1903426 regulation of reactive oxygen species biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9N9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9S9-1", "uniprot_id": [ { "id": "E1B9S9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9S9", "type": "external" } ], "mass": 219533.0, "length": 1972, "protein_name": "Voltage-dependent L-type calcium channel subunit alpha", "gene_name": "CACNA1F", "organism": "Bovine", "refseq_name": "voltage-dependent L-type calcium channel subunit alpha-1F", "refseq_ac": [ { "id": "NP_001192592", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192592", "type": "external" } ], "gene_names_uniprotkb": "CACNA1F", "gene_names_refseq": "CACNA1F", "protein_names_uniprotkb": "Voltage-dependent L-type calcium channel subunit alpha", "protein_names_refseq": "voltage-dependent L-type calcium channel subunit alpha-1F", "tax_id": 9913, "disease": "", "pathway": " (bta:509779)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1F gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, and by benzothiazepines. Activates at more negative voltages and does not undergo calcium-dependent inactivation (CDI), due to incoming calcium ions, during depolarization., [UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 1, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008331 high voltage-gated calcium channel activity", "go_cellular_component": "GO:0005891 voltage-gated calcium channel complex", "go_biological_process": "GO:0050908 detection of light stimulus involved in visual perception;GO:0098703 calcium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9S9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000011000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9X0-1", "uniprot_id": [ { "id": "E1B9X0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9X0", "type": "external" } ], "mass": 207440.0, "length": 1834, "protein_name": "Sodium channel protein", "gene_name": "SCN4A", "organism": "Bovine", "refseq_name": "sodium channel protein type 4 subunit alpha isoform X1", "refseq_ac": [ { "id": "XP_003587508", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587508", "type": "external" } ], "gene_names_uniprotkb": "SCN4A", "gene_names_refseq": "SCN4A", "protein_names_uniprotkb": "Sodium channel protein", "protein_names_refseq": "sodium channel protein type 4 subunit alpha isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:517426)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0030424 axon;GO:0001518 voltage-gated sodium channel complex", "go_biological_process": "GO:0019228 neuronal action potential;GO:0019233 sensory perception of pain;GO:0086010 membrane depolarization during action potential;GO:0035725 sodium ion transmembrane transport;GO:0100001 regulation of skeletal muscle contraction by action potential", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9X0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1B9Y5-1", "uniprot_id": [ { "id": "E1B9Y5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1B9Y5", "type": "external" } ], "mass": 86399.0, "length": 753, "protein_name": "Serine/threonine-protein phosphatase with EF-hands", "gene_name": "PPEF2", "organism": "Bovine", "refseq_name": "serine/threonine-protein phosphatase with EF-hands 2", "refseq_ac": [ { "id": "NP_001192906", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192906", "type": "external" } ], "gene_names_uniprotkb": "PPEF2", "gene_names_refseq": "PPEF2", "protein_names_uniprotkb": "Serine/threonine-protein phosphatase with EF-hands; 3.1.3.16", "protein_names_refseq": "serine/threonine-protein phosphatase with EF-hands 2", "tax_id": 9913, "disease": "", "pathway": " (bta:530344)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.74", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.74", "type": "external" }, { "id": "3.1.3.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.52", "type": "external" }, { "id": "3.1.3.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.53", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0030145 manganese ion binding;GO:0005509 calcium ion binding;GO:0004722 protein serine/threonine phosphatase activity;GO:0051879 Hsp90 protein binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0050906 detection of stimulus involved in sensory perception;GO:0007601 visual perception;GO:0070301 cellular response to hydrogen peroxide;GO:0043409 negative regulation of MAPK cascade;GO:2001234 negative regulation of apoptotic signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1B9Y5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BA06-1", "uniprot_id": [ { "id": "E1BA06_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BA06", "type": "external" } ], "mass": 23938.0, "length": 211, "protein_name": "Hypoxanthine phosphoribosyltransferase", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Hypoxanthine phosphoribosyltransferase; 2.4.2.8", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.2.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.8", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0000166 nucleotide binding;GO:0004422 hypoxanthine phosphoribosyltransferase activity;GO:0052657 guanine phosphoribosyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0032264 IMP salvage;GO:0006166 purine ribonucleoside salvage;GO:0006178 guanine salvage;GO:0046100 hypoxanthine metabolic process;GO:0032263 GMP salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BA06-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BA56-1", "uniprot_id": [ { "id": "E1BA56_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BA56", "type": "external" } ], "mass": 25457.0, "length": 237, "protein_name": "Homeobox protein MIXL1", "gene_name": "MIXL1", "organism": "Bovine", "refseq_name": "homeobox protein MIXL1", "refseq_ac": [ { "id": "XP_002694024", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694024", "type": "external" } ], "gene_names_uniprotkb": "MIXL1", "gene_names_refseq": "MIXL1", "protein_names_uniprotkb": "Homeobox protein MIXL1; Homeodomain protein MIX; MIX1 homeobox-like protein 1; Mix.1 homeobox-like protein", "protein_names_refseq": "homeobox protein MIXL1", "tax_id": 9913, "disease": "", "pathway": " (bta:614854)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0002244 hematopoietic progenitor cell differentiation;GO:0001706 endoderm formation;GO:1901533 negative regulation of hematopoietic progenitor cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BA56-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BA64-1", "uniprot_id": [ { "id": "E1BA64_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BA64", "type": "external" } ], "mass": 42481.0, "length": 397, "protein_name": "Homeobox protein aristaless-like 4", "gene_name": "ALX4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ALX4", "gene_names_refseq": "", "protein_names_uniprotkb": "Homeobox protein aristaless-like 4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, 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polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0071837 HMG box domain binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0001942 hair follicle development;GO:0048666 neuron development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BA64-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BAD7-1", "uniprot_id": [ { "id": "E1BAD7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BAD7", "type": "external" } ], "mass": 75093.0, "length": 738, "protein_name": "SIX homeobox 5", "gene_name": "SIX5", "organism": "Bovine", "refseq_name": "homeobox 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"kg_view_protein": true }, { "uniprot_canonical_ac": "E1BAL0-1", "uniprot_id": [ { "id": "E1BAL0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BAL0", "type": "external" } ], "mass": 59652.0, "length": 547, "protein_name": "CAP-Gly domain containing linker protein 3", "gene_name": "CLIP3", "organism": "Bovine", "refseq_name": "CAP-Gly domain-containing linker protein 3", "refseq_ac": [ { "id": "NP_001192827", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192827", "type": "external" } ], "gene_names_uniprotkb": "CLIP3", "gene_names_refseq": "CLIP3", "protein_names_uniprotkb": "CAP-Gly domain containing linker protein 3", "protein_names_refseq": "CAP-Gly domain-containing linker protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:522965); (R-BTA-5357905)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, 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Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003779 actin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042393 histone binding", "go_cellular_component": "GO:0005819 spindle;GO:0005874 microtubule;GO:0031011 Ino80 complex;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0033044 regulation of chromosome organization;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BAN8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEE9-1", "uniprot_id": [ { "id": "F1MEE9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEE9", "type": "external" } ], "mass": 116315.0, "length": 1050, "protein_name": "Rho family-interacting cell polarization regulator 2", "gene_name": "RIPOR2", "organism": "Bovine", "refseq_name": "rho family-interacting cell polarization regulator 2 isoform X1", "refseq_ac": [ { "id": "XP_005223838", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223838", "type": "external" } ], "gene_names_uniprotkb": "RIPOR2", "gene_names_refseq": "FAM65B; RIPOR2", "protein_names_uniprotkb": "Rho family-interacting cell polarization regulator 2", "protein_names_refseq": "rho family-interacting cell polarization regulator 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0016324 apical plasma membrane;GO:0030175 filopodium;GO:0060171 stereocilium membrane;GO:0005829 cytosol", "go_biological_process": "GO:0006935 chemotaxis;GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0007517 muscle organ development;GO:0007605 sensory perception of sound", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEE9-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNS0-1", "uniprot_id": [ { "id": "FXL15_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNS0", "type": "external" } ], "mass": 33152.0, "length": 300, "protein_name": "F-box/LRR-repeat protein 15", "gene_name": "FBXL15", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "FBXL15", "gene_names_refseq": "", "protein_names_uniprotkb": "F-box/LRR-repeat protein 15", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8951664); (R-BTA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005737 cytoplasm;GO:0019005 SCF ubiquitin ligase complex", "go_biological_process": "GO:0000086 G2/M transition of mitotic cell cycle;GO:0016567 protein ubiquitination;GO:0030513 positive regulation of BMP signaling pathway;GO:0009953 dorsal/ventral pattern formation;GO:0030282 bone mineralization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BNS0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BC15-1", "uniprot_id": [ { "id": "RBM44_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BC15", "type": "external" } ], "mass": 117960.0, "length": 1051, "protein_name": "RNA-binding protein 44", "gene_name": "RBM44", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RBM44", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA-binding protein 44; RNA-binding motif protein 44", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:789298)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Component of intercellular bridges during meiosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells. Not required for fertility (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003730 mRNA 3'-UTR binding;GO:0003723 RNA binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045171 intercellular bridge;GO:0071013 catalytic step 2 spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BC15-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJW1-1", "uniprot_id": [ { "id": "HTRA4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJW1", "type": "external" } ], "mass": 51220.0, "length": 484, "protein_name": "Serine protease HTR4", "gene_name": "HTRA4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "HTRA4", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine protease HTR4; 3.4.21.-; High-temperature requirement factor A4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:514946)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Serine protease., [UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005576 extracellular region", "go_biological_process": "GO:0006508 proteolysis;GO:0043065 positive regulation of apoptotic process;GO:0012501 programmed cell death", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BJW1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BFE9-1", "uniprot_id": [ { "id": "BI2L2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BFE9", "type": "external" } ], "mass": 59190.0, "length": 529, "protein_name": "BAR/IMD domain-containing adapter protein 2-like 2", "gene_name": "BAIAP2L2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "BAIAP2L2", "gene_names_refseq": "", "protein_names_uniprotkb": "BAR/IMD domain-containing adapter protein 2-like 2; BAI1-associated protein 2-like protein 2; Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2; Pinkbar; Planar intestinal- and kidney-specific BAR domain protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9035034)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphoinositides-binding protein that induces the formation of planar or gently curved membrane structures. Binds to phosphoinositides, including to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) headgroups. There seems to be no clear preference for a specific phosphoinositide (By similarity)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008289 lipid binding;GO:0005543 phospholipid binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0070161 anchoring junction", "go_biological_process": "GO:0007009 plasma membrane organization;GO:0051017 actin filament bundle assembly;GO:0051764 actin crosslink formation;GO:0030838 positive regulation of actin filament polymerization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BFE9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BP74-1", "uniprot_id": [ { "id": "MARF1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BP74", "type": "external" } ], "mass": 192127.0, "length": 1742, "protein_name": "Meiosis regulator and mRNA stability factor 1", "gene_name": "MARF1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MARF1; LKAP", "gene_names_refseq": "", "protein_names_uniprotkb": "Meiosis regulator and mRNA stability factor 1; Limkain-b1; Meiosis arrest female protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 6, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0004540 RNA nuclease activity;GO:1905762 CCR4-NOT complex binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005777 peroxisome", "go_biological_process": "GO:0007143 female meiotic nuclear division;GO:0010468 regulation of gene expression;GO:0048477 oogenesis;GO:0051321 meiotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BP74-1", "record_type": "protein", "filter_code": "0000000.0000100.010000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNG2-1", "uniprot_id": [ { "id": "E1BNG2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNG2", "type": "external" } ], "mass": 73552.0, "length": 659, "protein_name": "alpha-1,2-Mannosidase", "gene_name": "MAN1A1", "organism": "Bovine", "refseq_name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase IA", "refseq_ac": [ { "id": "NP_001192901", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192901", "type": "external" } ], "gene_names_uniprotkb": "MAN1A1", "gene_names_refseq": "MAN1A1", "protein_names_uniprotkb": "alpha-1,2-Mannosidase; 3.2.1.-", "protein_names_refseq": "mannosyl-oligosaccharide 1,2-alpha-mannosidase IA-like; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA", "tax_id": 9913, "disease": "", "pathway": " (bta:530027); (R-BTA-964827)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment;GO:0000139 Golgi membrane", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0036503 ERAD pathway;GO:0045047 protein targeting to ER", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BNG2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BP85-1", "uniprot_id": [ { "id": "E1BP85_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BP85", "type": "external" } ], "mass": 61094.0, "length": 549, "protein_name": "Uridine-cytidine kinase", "gene_name": "UCKL1", "organism": "Bovine", "refseq_name": "uridine-cytidine kinase-like 1 isoform X5", "refseq_ac": [ { "id": "XP_005214967", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005214967", "type": "external" } ], "gene_names_uniprotkb": "UCKL1", "gene_names_refseq": "UCKL1", "protein_names_uniprotkb": "Uridine-cytidine kinase; 2.7.1.48", "protein_names_refseq": "uridine-cytidine kinase-like 1 isoform X5", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-73614)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May contribute to UTP accumulation needed for blast transformation and proliferation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.48", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004849 uridine kinase activity;GO:0043771 cytidine kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:0008655 pyrimidine-containing compound salvage;GO:0044206 UMP salvage;GO:0044211 CTP salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BP85-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCW1-1", "uniprot_id": [ { "id": "E1BCW1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCW1", "type": "external" } ], "mass": 200520.0, "length": 1756, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "UBR2", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase UBR2", "refseq_ac": [ { "id": "NP_001179567", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179567", "type": "external" } ], "gene_names_uniprotkb": "UBR2", "gene_names_refseq": "UBR2", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase UBR2", "tax_id": 9913, "disease": "", "pathway": " (bta:527153); (R-BTA-983168)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.3.2.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0070728 L-leucine binding;GO:0141053 histone H2A ubiquitin ligase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0000785 chromatin;GO:0000151 ubiquitin ligase complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway;GO:0050862 positive regulation of T cell receptor signaling pathway;GO:0032007 negative regulation of TOR signaling;GO:0007140 male meiotic nuclear division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCW1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BBH7-1", "uniprot_id": [ { "id": "E1BBH7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BBH7", "type": "external" } ], "mass": 112253.0, "length": 1008, "protein_name": "Anion exchange protein", "gene_name": "SLC4A5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC4A5", "gene_names_refseq": "", "protein_names_uniprotkb": "Anion exchange protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-425381)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008509 monoatomic anion transmembrane transporter activity;GO:0005452 solute:inorganic anion antiporter activity;GO:0008510 sodium:bicarbonate symporter activity;GO:0015293 symporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0006814 sodium ion transport;GO:0055085 transmembrane transport;GO:0003014 renal system process;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BBH7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BIH4-1", "uniprot_id": [ { "id": "E1BIH4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BIH4", "type": "external" } ], "mass": 103911.0, "length": 912, "protein_name": "Tyrosine-protein phosphatase non-receptor type", "gene_name": "PTPN3", "organism": "Bovine", "refseq_name": "tyrosine-protein phosphatase non-receptor type 3", "refseq_ac": [ { "id": "NP_001192616", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192616", "type": "external" } ], "gene_names_uniprotkb": "PTPN3", "gene_names_refseq": "PTPN3", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type; 3.1.3.48", "protein_names_refseq": "tyrosine-protein phosphatase non-receptor type 3", "tax_id": 9913, "disease": "", "pathway": " (bta:511010); (R-BTA-182971); (R-BTA-5675221)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act at junctions between the membrane and the cytoskeleton., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0051117 ATPase binding;GO:0017080 sodium channel regulator activity;GO:0008092 cytoskeletal protein binding;GO:0004725 protein tyrosine phosphatase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0001917 photoreceptor inner segment;GO:0009898 cytoplasmic side of plasma membrane", "go_biological_process": "GO:0051045 negative regulation of membrane protein ectodomain proteolysis;GO:0045930 negative regulation of mitotic cell cycle;GO:0098902 regulation of membrane depolarization during action potential;GO:1902305 regulation of sodium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BIH4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNY9-1", "uniprot_id": [ { "id": "E1BNY9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNY9", "type": "external" } ], "mass": 482191.0, "length": 4375, "protein_name": "E3 ubiquitin-protein ligase HUWE1", "gene_name": "HUWE1", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase HUWE1", "refseq_ac": [ { "id": "NP_001103474", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103474", "type": "external" } ], "gene_names_uniprotkb": "HUWE1", "gene_names_refseq": "HUWE1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HUWE1; 2.3.2.26; HECT, UBA and WWE domain-containing protein 1; HECT-type E3 ubiquitin transferase HUWE1; Upstream regulatory element-binding protein 1", "protein_names_refseq": "E3 ubiquitin-protein ligase HUWE1; E3Histone; HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase", "tax_id": 9913, "disease": "", "pathway": " (bta:511826); (R-BTA-6798695); (R-BTA-983168)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "15767685", "class_list": "", "function": "E3Histone is therefore a HECT domain E3 that likely plays an important role in the chromatin condensation, [RefSeq, PubMed]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, 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"https://www.rhea-db.org/rhea/?query=ec:3.1.6.14", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "1.1.1.205", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.205", "type": "external" }, { "id": "2.3.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-", "type": "external" }, { "id": "2.7.1.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.11", "type": "external" }, { "id": "2.3.2.34", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34", "type": "external" }, { "id": "2.3.2.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.4.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.25", "type": "external" }, { "id": "3.2.1.33", 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"3.4.19.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.1", "type": "external" }, { "id": "2.7.1.35", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35", "type": "external" }, { "id": "2.4.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.1", "type": "external" }, { "id": "3.5.1.23", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23", "type": "external" }, { "id": "3.5.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-", "type": "external" }, { "id": "3.4.22.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.52", "type": "external" }, { "id": "2.3.3.8", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.8", "type": "external" }, { "id": "5.4.2.11", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.11", "type": "external" }, { "id": "5.4.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.4", "type": "external" }, { "id": "3.3.2.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6", "type": "external" }, { "id": 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"go_molecular_function": "GO:0003677 DNA binding;GO:0034450 ubiquitin-ubiquitin ligase activity;GO:0140852 histone ubiquitin ligase activity;GO:0061630 ubiquitin protein ligase activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031965 nuclear membrane;GO:0000139 Golgi membrane", "go_biological_process": "GO:0030154 cell differentiation;GO:0006284 base-excision repair;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0031398 positive regulation of protein ubiquitination;GO:0070936 protein K48-linked ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BNY9-1", "record_type": "protein", "filter_code": "0000000.0000101.001000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BMK0-1", "uniprot_id": [ { "id": "E1BMK0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BMK0", "type": "external" } ], "mass": 45642.0, "length": 402, "protein_name": "Decapping nuclease", "gene_name": "DXO", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DXO", "gene_names_refseq": "", "protein_names_uniprotkb": "Decapping nuclease; 3.6.1.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, 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"go_molecular_function": "GO:0003723 RNA binding;GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0004518 nuclease activity", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006402 mRNA catabolic process;GO:0110155 NAD-cap decapping;GO:0000956 nuclear-transcribed mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BMK0-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MCE7-1", "uniprot_id": [ { "id": "F1MCE7_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MCE7", "type": "external" } ], "mass": 60104.0, "length": 532, "protein_name": "receptor protein serine/threonine kinase", "gene_name": "BMPR1A", "organism": "Bovine", "refseq_name": "bone morphogenetic protein receptor type-1A isoform X1", "refseq_ac": [ { "id": "XP_005226588", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005226588", "type": "external" } ], "gene_names_uniprotkb": "BMPR1A", "gene_names_refseq": "BMPR-IA; BMPR1A", "protein_names_uniprotkb": "receptor protein serine/threonine kinase; 2.7.11.30", "protein_names_refseq": "bone morphogenetic protein receptor type-1A isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-201451)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.30", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.30", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0005025 transforming growth factor beta receptor activity, type I;GO:0046332 SMAD binding", "go_cellular_component": "GO:0009897 external side of plasma membrane;GO:0005901 caveola;GO:0005886 plasma membrane;GO:0043235 receptor complex", "go_biological_process": "GO:0001525 angiogenesis;GO:0006955 immune response;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007179 transforming growth factor beta receptor signaling pathway;GO:1904707 positive regulation of vascular associated smooth muscle cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MCE7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJW7-1", "uniprot_id": [ { "id": "E1BJW7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJW7", "type": "external" } ], "mass": 95370.0, "length": 841, "protein_name": "Vacuolar protein sorting-associated protein 53 homolog", "gene_name": "VPS53", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "VPS53", "gene_names_refseq": "", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 53 homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6811440)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Acts as a component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0000938 GARP complex;GO:0005829 cytosol;GO:0055037 recycling endosome;GO:0010008 endosome membrane;GO:1990745 EARP complex", "go_biological_process": "GO:0015031 protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0007041 lysosomal transport;GO:0006622 protein targeting to lysosome;GO:0032456 endocytic recycling", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BJW7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MBI5-1", "uniprot_id": [ { "id": "F1MBI5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MBI5", "type": "external" } ], "mass": 96263.0, "length": 872, "protein_name": "Phosphodiesterase", "gene_name": "PDE4A", "organism": "Bovine", "refseq_name": "3',5'-cyclic-AMP phosphodiesterase 4A isoform X1", "refseq_ac": [ { "id": "XP_024849890", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024849890", "type": "external" } ], "gene_names_uniprotkb": "PDE4A", "gene_names_refseq": "PDE4A", "protein_names_uniprotkb": "Phosphodiesterase; 3.1.4.-", "protein_names_refseq": "3',5'-cyclic-AMP phosphodiesterase 4A isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-180024); (R-BTA-418555)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.1.4.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1", "type": "external" }, { "id": "3.6.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9", "type": "external" }, { "id": "3.1.4.17", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17", "type": "external" }, { "id": "3.6.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.1", "type": "external" }, { "id": "3.6.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25", "type": "external" }, { "id": "3.6.1.14", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0030552 cAMP binding;GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity;GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0007165 signal transduction;GO:0006198 cAMP catabolic process;GO:0141162 negative regulation of cAMP/PKA signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MBI5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BFC2-1", "uniprot_id": [ { "id": "E1BFC2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BFC2", "type": "external" } ], "mass": 147668.0, "length": 1320, "protein_name": "Lysine-specific demethylase", "gene_name": "KDM3A", "organism": "Bovine", "refseq_name": "lysine-specific demethylase 3A", "refseq_ac": [ { "id": "NP_001179801", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179801", "type": "external" } ], "gene_names_uniprotkb": "KDM3A", "gene_names_refseq": "JMJD1A; KDM3A", "protein_names_uniprotkb": "Lysine-specific demethylase; 1.14.11.65", "protein_names_refseq": "jumonji domain containing 1A; lysine-specific demethylase 3A", "tax_id": 9913, "disease": "", "pathway": " (bta:536073); (R-BTA-3214842)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "24459992", "class_list": "", "function": "Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Histone demethylases KDM3A, KDM4A, and KDM4C were expressed before and after embryonic genome activation, whereas KDM5B was mainly expressed during the blastocyst period., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.11.65", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.65", "type": "external" }, { "id": "1.14.99.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.99.66", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0140683 histone H3K9me/H3K9me2 demethylase activity;GO:0003682 chromatin binding;GO:0005506 iron ion binding;GO:0050681 nuclear androgen receptor binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0000118 histone deacetylase complex;GO:0000785 chromatin", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0070988 demethylation;GO:0046293 formaldehyde biosynthetic process;GO:0045893 positive regulation of DNA-templated transcription;GO:0030521 androgen receptor signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BFC2-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MDC0-1", "uniprot_id": [ { "id": "F1MDC0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MDC0", "type": "external" } ], "mass": 122961.0, "length": 1099, "protein_name": "Ankyrin repeat and IBR domain-containing protein 1", "gene_name": "ANKIB1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ANKIB1", "gene_names_refseq": "", "protein_names_uniprotkb": "Ankyrin repeat and IBR domain-containing protein 1; 2.3.2.31", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Might act as an E3 ubiquitin-protein ligase, or as part of E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000151 ubiquitin ligase complex", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MDC0-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BGQ2-1", "uniprot_id": [ { "id": "ZCHC4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BGQ2", "type": "external" } ], "mass": 59485.0, "length": 516, "protein_name": "rRNA N(6)-adenosine-methyltransferase ZCCHC4", "gene_name": "ZCCHC4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ZCCHC4", "gene_names_refseq": "", "protein_names_uniprotkb": "rRNA N(6)-adenosine-methyltransferase ZCCHC4; 2.1.1.-; Zinc finger CCHC domain-containing protein 4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "rRNA N6-methyltransferase that specifically methylates the adenine in position 4220 of 28S rRNA. N6-methylation of adenine(4220) in 28S rRNA is required for translation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003676 nucleic acid binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0008988 rRNA (adenine-N6-)-methyltransferase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm", "go_biological_process": "GO:0031167 rRNA methylation;GO:0045727 positive regulation of translation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BGQ2-1", "record_type": "protein", "filter_code": "0000000.0000100.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BHG3-1", "uniprot_id": [ { "id": "E1BHG3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BHG3", "type": "external" } ], "mass": 134752.0, "length": 1247, "protein_name": "Cell adhesion molecule-related/down-regulated by oncogenes", "gene_name": "CDON", "organism": "Bovine", "refseq_name": "cell adhesion molecule-related/down-regulated by oncogenes precursor", "refseq_ac": [ { "id": "NP_001179799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179799", "type": "external" } ], "gene_names_uniprotkb": "CDON", "gene_names_refseq": "CDON", "protein_names_uniprotkb": "Cell adhesion molecule-related/down-regulated by oncogenes", "protein_names_refseq": "Cdon homolog; cell adhesion molecule-related/down-regulated by oncogenes precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:536011); (R-BTA-525793); (R-BTA-5632681); (R-BTA-5635838)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015026 coreceptor activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "GO:0007155 cell adhesion;GO:0007399 nervous system development;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0098609 cell-cell adhesion;GO:0007224 smoothened signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BHG3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJI0-1", "uniprot_id": [ { "id": "E1BJI0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJI0", "type": "external" } ], "mass": 225369.0, "length": 1985, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "TTC3", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase TTC3 isoform 1", "refseq_ac": [ { "id": "NP_001103237", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103237", "type": "external" } ], "gene_names_uniprotkb": "TTC3", "gene_names_refseq": "TTC3", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase TTC3 isoform 1", "tax_id": 9913, "disease": "", "pathway": " (bta:506569)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus", "go_biological_process": "GO:0006511 ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BJI0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJR7-1", "uniprot_id": [ { "id": "E1BJR7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJR7", "type": "external" } ], "mass": 103865.0, "length": 911, "protein_name": "Tyrosine-protein phosphatase non-receptor type", "gene_name": "PTPN4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTPN4", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type; 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"secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005829 cytosol;GO:0030659 cytoplasmic vesicle membrane;GO:0005886 plasma membrane;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0006886 intracellular protein transport;GO:0051044 positive regulation of membrane protein ectodomain proteolysis;GO:2000010 positive regulation of protein localization to cell surface;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BHK6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MDU0-1", "uniprot_id": [ { "id": "F1MDU0_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MDU0", "type": "external" } ], "mass": 78162.0, "length": 755, 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positive regulation of wound healing;GO:0016192 vesicle-mediated transport;GO:0007030 Golgi organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BP90-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNK2-1", "uniprot_id": [ { "id": "E1BNK2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNK2", "type": "external" } ], "mass": 169995.0, "length": 1514, "protein_name": "MutL homolog 3", "gene_name": "MLH3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MLH3", "gene_names_refseq": "", "protein_names_uniprotkb": "MutL homolog 3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, 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"secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0030983 mismatched DNA binding;GO:0140664 ATP-dependent DNA damage sensor activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0032300 mismatch repair complex;GO:0005712 chiasma;GO:0001673 male germ cell nucleus;GO:0000795 synaptonemal complex", "go_biological_process": "GO:0006298 mismatch repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BNK2-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BIQ2-1", "uniprot_id": [ { "id": "E1BIQ2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BIQ2", "type": "external" } ], "mass": 124306.0, "length": 1188, "protein_name": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2", "gene_name": "AGAP2", "organism": "Bovine", "refseq_name": "arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2", "refseq_ac": [ { "id": "NP_001178968", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178968", "type": "external" } ], "gene_names_uniprotkb": "AGAP2", "gene_names_refseq": "AGAP2", "protein_names_uniprotkb": "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2; Centaurin-gamma-1; Phosphatidylinositol 3-kinase enhancer", "protein_names_refseq": "arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:504833)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, 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cytoplasm;GO:0098978 glutamatergic synapse;GO:0016020 membrane;GO:0098794 postsynapse", "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0043524 negative regulation of neuron apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BIQ2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BE82-1", "uniprot_id": [ { "id": "E1BE82_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BE82", "type": "external" } ], "mass": 130014.0, "length": 1223, "protein_name": "Pumilio homolog 1", "gene_name": "PUM1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PUM1", "gene_names_refseq": "", "protein_names_uniprotkb": "Pumilio homolog 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", 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"length": 327, "protein_name": "Mitochondrial fission factor", "gene_name": "MFF", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MFF", "gene_names_refseq": "", "protein_names_uniprotkb": "Mitochondrial fission factor", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0032991 protein-containing complex", "go_biological_process": "GO:0090314 positive regulation of protein targeting to membrane;GO:0000266 mitochondrial fission;GO:0090141 positive regulation of mitochondrial fission;GO:0016559 peroxisome fission;GO:0006626 protein targeting to mitochondrion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BLP4-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MDW1-1", "uniprot_id": [ { "id": "F1MDW1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MDW1", "type": "external" } ], "mass": 101517.0, "length": 906, "protein_name": "Methionine--tRNA ligase, cytoplasmic", "gene_name": "MARS1", "organism": "Bovine", "refseq_name": "methionine--tRNA ligase, cytoplasmic isoform X1", "refseq_ac": [ { "id": "XP_024847411", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024847411", "type": "external" } ], "gene_names_uniprotkb": "MARS1", "gene_names_refseq": "MARS1; MARS", "protein_names_uniprotkb": "Methionine--tRNA ligase, cytoplasmic; 6.1.1.10; Methionyl-tRNA synthetase", "protein_names_refseq": "methionine--tRNA ligase, cytoplasmic isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9856649)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Plays a role in the synthesis of ribosomal RNA in the nucleolus., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.1.1.4", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.4", "type": "external" }, { "id": "6.1.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.6", "type": "external" }, { "id": "6.1.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.15", "type": "external" }, { "id": "6.1.1.17", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.17", "type": "external" }, { "id": "6.1.1.10", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.10", "type": "external" }, { "id": "6.1.1.19", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.19", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "6.1.1.12", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.12", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "6.1.1.18", "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.18", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0000049 tRNA binding;GO:0004825 methionine-tRNA ligase activity", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0017101 aminoacyl-tRNA synthetase multienzyme complex;GO:0005737 cytoplasm", "go_biological_process": "GO:0006431 methionyl-tRNA aminoacylation;GO:0009303 rRNA transcription;GO:0071364 cellular response to epidermal growth factor stimulus;GO:0036120 cellular response to platelet-derived growth factor stimulus;GO:1901838 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MDW1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJH5-1", "uniprot_id": [ { "id": "E1BJH5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJH5", "type": "external" } ], "mass": 101331.0, "length": 894, "protein_name": "Mitogen-activated protein kinase kinase kinase kinase", "gene_name": "MAP4K3", "organism": "Bovine", "refseq_name": "mitogen-activated protein kinase kinase kinase kinase 3", "refseq_ac": [ { "id": "NP_001178091", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178091", "type": "external" } ], "gene_names_uniprotkb": "MAP4K3", "gene_names_refseq": "MAP4K3", "protein_names_uniprotkb": "Mitogen-activated protein kinase kinase kinase kinase; 2.7.11.1", "protein_names_refseq": "mitogen-activated protein kinase kinase kinase kinase 3", "tax_id": 9913, "disease": "", "pathway": " (bta:507624)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine kinase that plays a role in the response to environmental stress. 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"https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0008349 MAP kinase kinase kinase kinase activity;GO:0106310 protein serine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0034612 response to tumor necrosis factor;GO:0035556 intracellular signal transduction;GO:0009411 response to UV", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BJH5-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MAZ8-1", "uniprot_id": [ { "id": "F1MAZ8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MAZ8", "type": "external" } ], "mass": 89089.0, "length": 798, "protein_name": "MAP/microtubule affinity-regulating kinase 3", "gene_name": "MARK3", "organism": "Bovine", "refseq_name": "MAP/microtubule affinity-regulating kinase 3 isoform X2", "refseq_ac": [ { "id": "XP_059735357", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059735357", "type": "external" } ], "gene_names_uniprotkb": "MARK3", "gene_names_refseq": "MARK3", "protein_names_uniprotkb": "MAP/microtubule affinity-regulating kinase 3; 2.7.11.1", "protein_names_refseq": "MAP/microtubule affinity-regulating kinase 3 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:534872); (R-BTA-5673000); (R-BTA-5674135); (R-BTA-5675221); (R-BTA-9856649)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in sperm motility, especially in the regulation of flagellar function., [UniProtKB, UniProtKB, UniProtKB]; Serine/threonine-protein kinase. Involved in the specific phosphorylation of microtubule-associated proteins for MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Phosphorylates CDC25C on 'Ser-216'. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Regulates localization and activity of MITF by mediating its phosphorylation, promoting subsequent interaction between MITF and 14-3-3 and retention in the cytosol. Negatively regulates the Hippo signaling pathway and antagonizes the phosphorylation of LATS1. Cooperates with DLG5 to inhibit the kinase activity of STK3/MST2 toward LATS1. Phosphorylates PKP2 and KSR1., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, 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{ "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0106310 protein serine kinase activity;GO:0050321 tau-protein kinase activity;GO:0019903 protein 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"E1BK86-1", "record_type": "protein", "filter_code": "0000000.0000000.001000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BE13-1", "uniprot_id": [ { "id": "E1BE13_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BE13", "type": "external" } ], "mass": 533093.0, "length": 4888, "protein_name": "Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6", "gene_name": "BIRC6", "organism": "Bovine", "refseq_name": "dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6 isoform 1", "refseq_ac": [ { "id": "XP_024854609", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024854609", "type": "external" } ], "gene_names_uniprotkb": "BIRC6", "gene_names_refseq": "BIRC6", "protein_names_uniprotkb": "Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6; 2.3.2.24; BIR repeat-containing ubiquitin-conjugating enzyme; Baculoviral IAP repeat-containing protein 6; Ubiquitin-conjugating BIR domain enzyme 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"synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BE13-1", "record_type": "protein", "filter_code": "0000000.0000000.000100.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKT3-1", "uniprot_id": [ { "id": "E1BKT3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKT3", "type": "external" } ], "mass": 162931.0, "length": 1460, "protein_name": "Erbin", "gene_name": "ERBIN", "organism": "Bovine", "refseq_name": "erbin isoform X1", "refseq_ac": [ { "id": "XP_005221508", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221508", "type": "external" } ], "gene_names_uniprotkb": "ERBIN", "gene_names_refseq": "ERBIN", "protein_names_uniprotkb": "Erbin; Densin-180-like protein; Erbb2-interacting protein; Protein LAP2", "protein_names_refseq": "erbin isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:512866)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", 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0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0031965 nuclear membrane;GO:0030056 hemidesmosome;GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm", "go_biological_process": "GO:0010468 regulation of gene expression;GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway;GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane;GO:0032496 response to lipopolysaccharide;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BKT3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BIT6-1", "uniprot_id": [ { "id": "E1BIT6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BIT6", "type": "external" } ], "mass": 80472.0, "length": 711, "protein_name": "Polyunsaturated fatty acid lipoxygenase ALOX15", "gene_name": "ALOXE3", "organism": "Bovine", "refseq_name": "hydroperoxide isomerase ALOXE3", "refseq_ac": [ { "id": "XP_003587465", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587465", "type": "external" } ], "gene_names_uniprotkb": "ALOXE3", "gene_names_refseq": "ALOXE3", "protein_names_uniprotkb": "Polyunsaturated fatty acid lipoxygenase ALOX15; 1.13.11.12; 12/15-lipoxygenase; Arachidonate 12-lipoxygenase, leukocyte-type; Arachidonate 15-lipoxygenase; Arachidonate omega-6 lipoxygenase; Erythroid cell-specific 15-lipoxygenase; Hepoxilin A3 synthase Alox15; Linoleate 13S-lipoxygenase", "protein_names_refseq": "hydroperoxide isomerase ALOXE3", "tax_id": 9913, "disease": "", "pathway": " (bta:517001); (R-BTA-2142712)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", 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"biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.13.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.12", "type": "external" }, { "id": "1.13.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.31", "type": "external" }, { "id": "1.13.11.33", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.33", "type": "external" }, { "id": "1.13.11.34", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.34", "type": "external" }, { "id": "1.13.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-", "type": "external" } ], "go_molecular_function": "GO:0005506 iron ion binding;GO:0008289 lipid binding;GO:0004052 arachidonate 12(S)-lipoxygenase activity;GO:0016165 linoleate 13S-lipoxygenase activity;GO:0106255 hydroperoxy icosatetraenoate isomerase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005811 lipid droplet;GO:0016020 membrane", "go_biological_process": "GO:0034440 lipid oxidation;GO:0019369 arachidonate metabolic process;GO:0046513 ceramide biosynthetic process;GO:0061436 establishment of skin barrier;GO:0043651 linoleic acid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BIT6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BPA0-1", "uniprot_id": [ { "id": "E1BPA0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BPA0", "type": "external" } ], "mass": 96630.0, "length": 856, "protein_name": "Receptor-type tyrosine-protein phosphatase alpha", "gene_name": "PTPRA", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTPRA", "gene_names_refseq": "", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase alpha; 3.1.3.48", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-375165); (R-BTA-5673001)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tyrosine protein phosphatase which is involved in integrin-mediated focal adhesion formation. Following integrin engagement, specifically recruits BCAR3, BCAR1 and CRK to focal adhesions thereby promoting SRC-mediated phosphorylation of BRAC1 and the subsequent activation of PAK and small GTPase RAC1 and CDC42., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0043235 receptor complex", "go_biological_process": "GO:0007165 signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BPA0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BQ25-1", "uniprot_id": [ { "id": "E1BQ25_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BQ25", "type": "external" } ], "mass": 46709.0, "length": 418, "protein_name": "Inhibitor of growth protein", "gene_name": "ING3", "organism": "Bovine", "refseq_name": "inhibitor of growth protein 3", "refseq_ac": [ { "id": "NP_001179873", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179873", "type": "external" } ], "gene_names_uniprotkb": "ING3", "gene_names_refseq": "ING3", "protein_names_uniprotkb": "Inhibitor of growth protein", "protein_names_refseq": "inhibitor of growth protein 3", "tax_id": 9913, "disease": "", "pathway": " (bta:513000)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of an histone acetyltransferase complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0043997 histone H4K12 acetyltransferase activity;GO:0043995 histone H4K5 acetyltransferase activity;GO:0043996 histone H4K8 acetyltransferase activity;GO:0046972 histone H4K16 acetyltransferase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex;GO:0032777 piccolo histone acetyltransferase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:0051726 regulation of cell cycle;GO:1905168 positive regulation of double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BQ25-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BQ37-1", "uniprot_id": [ { "id": "E1BQ37_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BQ37", "type": "external" } ], "mass": 78693.0, "length": 728, "protein_name": "Splicing factor proline and glutamine rich", "gene_name": "SFPQ", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SFPQ", "gene_names_refseq": "", "protein_names_uniprotkb": "Splicing factor proline and glutamine rich", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8849468)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003723 RNA binding;GO:0003682 chromatin binding;GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding;GO:0000976 transcription cis-regulatory region binding", "go_cellular_component": "GO:0016607 nuclear speck;GO:0016363 nuclear matrix;GO:0042382 paraspeckles;GO:0005634 nucleus;GO:0030425 dendrite", "go_biological_process": "GO:0098963 dendritic transport of messenger ribonucleoprotein complex;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BQ37-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCK1-1", "uniprot_id": [ { "id": "E1BCK1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCK1", "type": "external" } ], "mass": 282003.0, "length": 2540, "protein_name": "Telomere-associated protein RIF1", "gene_name": "RIF1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RIF1", "gene_names_refseq": "", "protein_names_uniprotkb": "Telomere-associated protein RIF1; Rap1-interacting factor 1 homolog", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5693571)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM-phosphorylated TP53BP1. Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs. Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase. Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs. Promotes NHEJ of dysfunctional telomeres., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "", "go_cellular_component": "GO:0005634 nucleus;GO:0005819 spindle;GO:0035861 site of double-strand break;GO:0000781 chromosome, telomeric region;GO:0005654 nucleoplasm", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining;GO:0006281 DNA repair;GO:0000723 telomere maintenance;GO:0031509 subtelomeric heterochromatin formation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCK1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BI37-1", "uniprot_id": [ { "id": "E1BI37_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BI37", "type": "external" } ], "mass": 55617.0, "length": 488, "protein_name": "Ig-like domain-containing protein", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Ig-like domain-containing protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1236974); (R-BTA-1236977); (R-BTA-198933); (R-BTA-6798695); (R-BTA-983170)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, 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"go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030881 beta-2-microglobulin binding;GO:0042605 peptide antigen binding", "go_cellular_component": "GO:0030670 phagocytic vesicle membrane;GO:0042612 MHC class I protein complex;GO:0098553 lumenal side of endoplasmic reticulum membrane;GO:0005615 extracellular space;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0006955 immune response;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I;GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BI37-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BP87-1", "uniprot_id": [ { "id": "E1BP87_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BP87", "type": "external" } ], "mass": 222537.0, "length": 1935, "protein_name": "Myosin heavy chain 4", "gene_name": "MYH4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MYH4", "gene_names_refseq": "", "protein_names_uniprotkb": "Myosin heavy chain 4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, 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myofibril;GO:0016459 myosin complex;GO:0005737 cytoplasm;GO:0016460 myosin II complex", "go_biological_process": "GO:0006936 muscle contraction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BP87-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MD22-1", "uniprot_id": [ { "id": "F1MD22_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MD22", "type": "external" } ], "mass": 162332.0, "length": 1446, "protein_name": "Receptor-type tyrosine-protein phosphatase U", "gene_name": "PTPRU", "organism": "Bovine", "refseq_name": "receptor-type tyrosine-protein phosphatase U precursor", "refseq_ac": [ { "id": "NP_001178423", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178423", "type": "external" } ], "gene_names_uniprotkb": "PTPRU", "gene_names_refseq": "PTPRU", "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase U; 3.1.3.48; Pancreatic carcinoma phosphatase 2; Receptor-type protein-tyrosine phosphatase psi", "protein_names_refseq": "receptor-type tyrosine-protein phosphatase U precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:535675); (R-BTA-1433557)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2", "type": "external" }, { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.21", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21", "type": "external" }, { "id": "3.1.3.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "3.1.3.18", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18", "type": "external" } ], "go_molecular_function": "GO:0008013 beta-catenin binding;GO:0004725 protein tyrosine phosphatase activity;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0070161 anchoring junction;GO:0005911 cell-cell junction", "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation;GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0031175 neuron projection development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MD22-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BL95-1", "uniprot_id": [ { "id": "E1BL95_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BL95", "type": "external" } ], "mass": 153817.0, "length": 1354, "protein_name": "Centrosomal P4.1-associated protein", "gene_name": "CENPJ", "organism": "Bovine", "refseq_name": "centromere protein J isoform X1", "refseq_ac": [ { "id": "XP_002691898", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691898", "type": "external" } ], "gene_names_uniprotkb": "CENPJ", "gene_names_refseq": "CENPJ", "protein_names_uniprotkb": "Centrosomal P4.1-associated protein; Centromere protein J; Centrosome assembly and centriole elongation protein", "protein_names_refseq": "centromere protein J isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:613543); (R-BTA-2565942); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-6804115); (R-BTA-8854518)", "pathway_count": 9, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015631 tubulin binding", "go_cellular_component": "GO:0005874 microtubule;GO:0005814 centriole;GO:0005813 centrosome;GO:0036064 ciliary basal body", "go_biological_process": "GO:1902117 positive regulation of organelle assembly;GO:0007099 centriole replication;GO:0060271 cilium assembly;GO:0061511 centriole elongation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BL95-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BF68-1", "uniprot_id": [ { "id": "E1BF68_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BF68", "type": "external" } ], "mass": 119856.0, "length": 1045, "protein_name": "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16", "gene_name": "DHX16", "organism": "Bovine", "refseq_name": "pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16", "refseq_ac": [ { "id": "NP_001193139", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193139", "type": "external" } ], "gene_names_uniprotkb": "DHX16", "gene_names_refseq": "DHX16", "protein_names_uniprotkb": "Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16; 3.6.4.13; DEAH-box protein 16", "protein_names_refseq": "DEAH (Asp-Glu-Ala-His) box polypeptide 16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16", "tax_id": 9913, "disease": "", "pathway": " (bta:506405); (R-BTA-72163)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Required for pre-mRNA splicing as a component of the spliceosome. Contributes to pre-mRNA splicing after spliceosome formation and prior to the first transesterification reaction. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. Also plays a role in innate antiviral response by acting as a pattern recognition receptor sensing splicing signals in viral RNA. Mechanistically, TRIM6 promotes the interaction between unanchored 'Lys-48'-polyubiquitin chains and DHX16, leading to DHX16 interaction with RIGI and ssRNA to amplify RIGI-dependent innate antiviral immune responses., [UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, 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"https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "5.2.1.8", "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0003676 nucleic acid binding;GO:0003724 RNA helicase activity;GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005681 spliceosomal complex;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0071005 U2-type precatalytic spliceosome", "go_biological_process": "GO:0000398 mRNA splicing, via spliceosome;GO:0140374 antiviral innate immune response", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BF68-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MC11-1", "uniprot_id": [ { "id": "F1MC11_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MC11", "type": "external" } ], "mass": 55895.0, "length": 515, "protein_name": "Keratin, type I cytoskeletal 14", "gene_name": "KRT14", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "KRT14", "gene_names_refseq": "", "protein_names_uniprotkb": "Keratin, type I cytoskeletal 14; Cytokeratin-14; Keratin-14", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6805567); (R-BTA-6809371)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005198 structural molecule activity;GO:1990254 keratin filament binding;GO:0030280 structural constituent of skin epidermis", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005882 intermediate filament;GO:0005856 cytoskeleton;GO:0045178 basal part of cell", "go_biological_process": "GO:0045110 intermediate filament bundle assembly;GO:0030216 keratinocyte differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium;GO:0042633 hair cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MC11-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BPY4-1", "uniprot_id": [ { "id": "E1BPY4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BPY4", "type": "external" } ], "mass": 158945.0, "length": 1465, "protein_name": "Nuclear receptor coactivator", "gene_name": "NCOA2", "organism": "Bovine", "refseq_name": "nuclear receptor coactivator 2 isoform X1", "refseq_ac": [ { "id": "XP_024857606", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024857606", "type": "external" } ], "gene_names_uniprotkb": "NCOA2", "gene_names_refseq": "NCOA2", "protein_names_uniprotkb": "Nuclear receptor coactivator", "protein_names_refseq": "nuclear receptor coactivator 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:508162); (R-BTA-159418); (R-BTA-192105); (R-BTA-193368); (R-BTA-193807); (R-BTA-211976); (R-BTA-3214847); (R-BTA-400206); (R-BTA-5625886); (R-BTA-9018519); (R-BTA-9707564); (R-BTA-9841922)", "pathway_count": 12, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3. Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0046983 protein dimerization activity;GO:0016922 nuclear receptor binding;GO:0003682 chromatin binding;GO:0019904 protein domain specific binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048511 rhythmic process;GO:0010906 regulation of glucose metabolic process;GO:0019216 regulation of lipid metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BPY4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BE66-1", "uniprot_id": [ { "id": "E1BE66_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BE66", "type": "external" } ], "mass": 119776.0, "length": 1043, "protein_name": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform", "gene_name": "PIK3CD", "organism": "Bovine", "refseq_name": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2", "refseq_ac": [ { "id": "XP_010811548", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010811548", "type": "external" } ], "gene_names_uniprotkb": "PIK3CD", "gene_names_refseq": "PIK3CD", "protein_names_uniprotkb": "Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; 2.7.1.137; 2.7.1.153; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta", "protein_names_refseq": "phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1257604); (R-BTA-1660499); (R-BTA-389357); (R-BTA-512988); (R-BTA-6811558); (R-BTA-8853659); (R-BTA-9027276); (R-BTA-912526); (R-BTA-912631); (R-BTA-983695); (R-BTA-9927354)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.5.2", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0046934 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity;GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005942 phosphatidylinositol 3-kinase complex", "go_biological_process": "GO:0006935 chemotaxis;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway;GO:0010628 positive regulation of gene expression;GO:0030154 cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BE66-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEN8-1", "uniprot_id": [ { "id": "F1MEN8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEN8", "type": "external" } ], "mass": 72498.0, "length": 643, "protein_name": "Protein disulfide-isomerase A4", "gene_name": "PDIA4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PDIA4", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein disulfide-isomerase A4; 5.3.4.1; Endoplasmic reticulum resident protein 72", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003756 protein disulfide isomerase activity;GO:0015035 protein-disulfide reductase activity", "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen;GO:0042470 melanosome;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0009986 cell surface", "go_biological_process": "GO:0006457 protein folding;GO:0034976 response to endoplasmic reticulum stress", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEN8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BAT1-1", "uniprot_id": [ { "id": "E1BAT1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BAT1", "type": "external" } ], "mass": 84649.0, "length": 728, "protein_name": "Hook microtubule tethering protein 1", "gene_name": "HOOK1", "organism": "Bovine", "refseq_name": "protein Hook homolog 1", "refseq_ac": [ { "id": "NP_001193799", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193799", "type": "external" } ], "gene_names_uniprotkb": "HOOK1", "gene_names_refseq": "HOOK1", "protein_names_uniprotkb": "Hook microtubule tethering protein 1", "protein_names_refseq": "hook homolog 1; protein Hook homolog 1-like; protein Hook homolog 1", "tax_id": 9913, "disease": "", "pathway": " (bta:785042)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0003779 actin binding;GO:0042803 protein homodimerization activity;GO:0051959 dynein light intermediate chain binding", "go_cellular_component": "GO:0005874 microtubule;GO:0030897 HOPS complex;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0070695 FHF complex", "go_biological_process": "GO:0030705 cytoskeleton-dependent intracellular transport;GO:0010256 endomembrane system organization;GO:0031122 cytoplasmic microtubule organization;GO:0007032 endosome organization;GO:0007040 lysosome organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BAT1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKN0-1", "uniprot_id": [ { "id": "E1BKN0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKN0", "type": "external" } ], "mass": 293366.0, "length": 2711, "protein_name": "Histone-lysine N-methyltransferase 2B", "gene_name": "KMT2B", "organism": "Bovine", "refseq_name": "histone-lysine N-methyltransferase 2B isoform X2", "refseq_ac": [ { "id": "XP_003587289", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003587289", "type": "external" } ], "gene_names_uniprotkb": "KMT2B", "gene_names_refseq": "KMT2B", "protein_names_uniprotkb": "Histone-lysine N-methyltransferase 2B; 2.1.1.364; Trithorax homolog 2; WW domain-binding protein 7", "protein_names_refseq": "histone-lysine N-methyltransferase 2B isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:785776); (R-BTA-201722); (R-BTA-3214841); (R-BTA-8936459); (R-BTA-9772755)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place. Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 5, "predicted_n_glycosites": 0, "predicted_o_glycosites": 5, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 5, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.1.1.85", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.1.1.364", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364", "type": "external" }, { "id": "2.1.1.319", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319", "type": "external" }, { "id": "2.1.1.359", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359", "type": "external" }, { "id": "2.1.1.355", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.355", "type": "external" }, { "id": "2.1.1.354", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.354", "type": "external" }, { "id": "2.1.1.362", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.362", "type": "external" }, { "id": "2.1.1.361", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.361", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0140945 histone H3K4 monomethyltransferase activity;GO:0042800 histone H3K4 methyltransferase activity;GO:0045322 unmethylated CpG binding", "go_cellular_component": "GO:0035097 histone methyltransferase complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0032259 methylation;GO:0045893 positive regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BKN0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BC84-1", "uniprot_id": [ { "id": "E1BC84_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BC84", "type": "external" } ], "mass": 101842.0, "length": 910, "protein_name": "Trafficking kinesin protein 2", "gene_name": "TRAK2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TRAK2", "gene_names_refseq": "", "protein_names_uniprotkb": "Trafficking kinesin protein 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9013419); (R-BTA-9013425)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017022 myosin binding;GO:0050811 GABA receptor binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0030425 dendrite;GO:0031410 cytoplasmic vesicle", "go_biological_process": "GO:0006605 protein targeting;GO:0022008 neurogenesis;GO:0048311 mitochondrion distribution;GO:0047496 vesicle transport along microtubule", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BC84-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BPR4-1", "uniprot_id": [ { "id": "E1BPR4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BPR4", "type": "external" } ], "mass": 157463.0, "length": 1460, "protein_name": "SEC24 homolog B, COPII coat complex component", "gene_name": "SEC24B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SEC24B", "gene_names_refseq": "", "protein_names_uniprotkb": "SEC24 homolog B, COPII coat complex component", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-204005); (R-BTA-2132295); (R-BTA-5694530); (R-BTA-983170)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000149 SNARE binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane;GO:0030127 COPII vesicle coat;GO:0070971 endoplasmic reticulum exit site", "go_biological_process": "GO:0006886 intracellular protein transport;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport;GO:0090110 COPII-coated vesicle cargo loading", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BPR4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BPY0-1", "uniprot_id": [ { "id": "E1BPY0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BPY0", "type": "external" } ], "mass": 54821.0, "length": 501, "protein_name": "Wiskott-Aldrich syndrome protein family member", "gene_name": "WASF3", "organism": "Bovine", "refseq_name": "actin-binding protein WASF3", "refseq_ac": [ { "id": "NP_001179942", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179942", "type": "external" } ], "gene_names_uniprotkb": "WASF3", "gene_names_refseq": "WASF3", "protein_names_uniprotkb": "Wiskott-Aldrich syndrome protein family member; WASP family protein member", "protein_names_refseq": "WAS protein family member 3; actin-binding protein WASF3", "tax_id": 9913, "disease": "", "pathway": " (bta:540674); (R-BTA-2029482); (R-BTA-5663213)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0034237 protein kinase A regulatory subunit binding;GO:0071933 Arp2/3 complex binding", "go_cellular_component": "GO:0005856 cytoskeleton;GO:0098978 glutamatergic synapse;GO:0030027 lamellipodium;GO:0098794 postsynapse;GO:0031209 SCAR complex", "go_biological_process": "GO:0030036 actin cytoskeleton organization;GO:0098885 modification of postsynaptic actin cytoskeleton;GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BPY0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BPL3-1", "uniprot_id": [ { "id": "E1BPL3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BPL3", "type": "external" } ], "mass": 82928.0, "length": 752, "protein_name": "Iron-sulfur clusters transporter ABCB7, mitochondrial", "gene_name": "ABCB7", "organism": "Bovine", "refseq_name": "iron-sulfur clusters transporter ABCB7, mitochondrial isoform 1", "refseq_ac": [ { "id": "NP_001179712", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179712", "type": "external" } ], "gene_names_uniprotkb": "ABCB7", "gene_names_refseq": "ABCB7", "protein_names_uniprotkb": "Iron-sulfur clusters transporter ABCB7, mitochondrial; ATP-binding cassette sub-family B member 7, mitochondrial; ATP-binding cassette transporter 7", "protein_names_refseq": "ATP-binding cassette, sub-family B (MDR/TAP), member 7; iron-sulfur clusters transporter ABCB7, mitochondrial isoform 1", "tax_id": 9913, "disease": "", "pathway": " (bta:533669); (R-BTA-1369007)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis. Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis. In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1. May also play a role in hematopoiesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0140359 ABC-type transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0005743 mitochondrial inner membrane;GO:0031966 mitochondrial membrane", "go_biological_process": "GO:0006879 intracellular iron ion homeostasis;GO:0055085 transmembrane transport;GO:0016226 iron-sulfur cluster assembly;GO:0140466 iron-sulfur cluster export from the mitochondrion;GO:0070455 positive regulation of heme biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BPL3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BMY0-1", "uniprot_id": [ { "id": "E1BMY0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BMY0", "type": "external" } ], "mass": 142353.0, "length": 1316, "protein_name": "Poly [ADP-ribose] polymerase", "gene_name": "TNKS2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TNKS2", "gene_names_refseq": "", "protein_names_uniprotkb": "Poly [ADP-ribose] polymerase; 2.4.2.-; PARP", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-201681); (R-BTA-4641257); (R-BTA-5689880); (R-BTA-8948751)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.67", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.4.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.-", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.4.25.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0016779 nucleotidyltransferase activity;GO:0003950 NAD+ poly-ADP-ribosyltransferase activity;GO:1990404 NAD+-protein mono-ADP-ribosyltransferase activity;GO:0019899 enzyme binding", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0000781 chromosome, telomeric region;GO:0005635 nuclear envelope;GO:0005737 cytoplasm", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0070213 protein auto-ADP-ribosylation;GO:0070198 protein localization to chromosome, telomeric region;GO:0090263 positive regulation of canonical Wnt signaling pathway;GO:0000209 protein polyubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BMY0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BMK3-1", "uniprot_id": [ { "id": "E1BMK3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BMK3", "type": "external" } ], "mass": 119542.0, "length": 1069, "protein_name": "E3 ubiquitin-protein ligase RNF31", "gene_name": "RNF31", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "RNF31", "gene_names_refseq": "", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF31; 2.3.2.31; HOIL-1-interacting protein; RING finger protein 31; RING-type E3 ubiquitin transferase RNF31", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5357786); (R-BTA-5357905); (R-BTA-5357956)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.3.2.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0036435 K48-linked polyubiquitin modification-dependent protein binding;GO:0042802 identical protein binding;GO:0031625 ubiquitin protein ligase binding", "go_cellular_component": "GO:0071797 LUBAC complex;GO:0005829 cytosol;GO:0009898 cytoplasmic side of plasma membrane;GO:0035631 CD40 receptor complex", "go_biological_process": "GO:0097039 protein linear polyubiquitination;GO:0023035 CD40 signaling 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"protein_names_refseq": "spatacsin isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:507819)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, 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"https://www.uniprot.org/uniprot/F1MB07", "type": "external" } ], "mass": 103876.0, "length": 911, "protein_name": "DNA ligase", "gene_name": "LIG4", "organism": "Bovine", "refseq_name": "DNA ligase 4", "refseq_ac": [ { "id": "NP_001178055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178055", "type": "external" } ], "gene_names_uniprotkb": "LIG4", "gene_names_refseq": "LIG4", "protein_names_uniprotkb": "DNA ligase; 6.5.1.1", "protein_names_refseq": "DNA ligase 4", "tax_id": 9913, "disease": "", "pathway": " (bta:781252); (R-BTA-5693571)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyzes the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps. Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. 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(R-BTA-8985586); (R-BTA-9013106); (R-BTA-9013148); (R-BTA-9035034)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005096 GTPase activator activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0000146 microfilament motor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016459 myosin complex;GO:0098871 postsynaptic actin cytoskeleton;GO:0005829 cytosol;GO:0005884 actin filament", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0030048 actin filament-based movement;GO:0035023 regulation of Rho protein signal transduction;GO:0072673 lamellipodium morphogenesis;GO:0035385 Roundabout signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BNV7-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BDX1-1", "uniprot_id": [ { "id": "E1BDX1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BDX1", "type": "external" } ], "mass": 134043.0, "length": 1210, "protein_name": "CST complex subunit CTC1", "gene_name": "CTC1", "organism": "Bovine", "refseq_name": "CST complex subunit CTC1 isoform X1", "refseq_ac": [ { "id": "XP_002695914", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002695914", "type": "external" } ], "gene_names_uniprotkb": "CTC1", "gene_names_refseq": "CTC1", "protein_names_uniprotkb": "CST complex subunit CTC1", "protein_names_refseq": "CST complex subunit CTC1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:513500); 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43 kDa postsynaptic protein; Acetylcholine receptor-associated 43 kDa protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. 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"reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0033130 acetylcholine receptor binding;GO:0043495 protein-membrane adaptor activity;GO:0098879 structural constituent of postsynaptic specialization", "go_cellular_component": "GO:0005737 cytoplasm;GO:0045202 synapse;GO:0005794 Golgi apparatus;GO:0005856 cytoskeleton;GO:0005886 plasma membrane", "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0007271 synaptic transmission, cholinergic;GO:0071340 skeletal muscle acetylcholine-gated channel clustering;GO:1900075 positive regulation of neuromuscular synaptic transmission;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BJL1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BDC9-1", "uniprot_id": [ { "id": "E1BDC9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BDC9", "type": "external" } ], "mass": 79545.0, "length": 701, "protein_name": "Vacuolar protein sorting-associated protein 52 homolog", "gene_name": "VPS52", "organism": "Bovine", "refseq_name": "vacuolar protein sorting-associated protein 52 homolog isoform X1", "refseq_ac": [ { "id": "XP_005223289", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005223289", "type": "external" } ], "gene_names_uniprotkb": "VPS52", "gene_names_refseq": "VPS52", "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 52 homolog", "protein_names_refseq": "vacuolar protein sorting-associated protein 52 homolog isoform X1", "tax_id": 9913, "disease": "", 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0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0019905 syntaxin binding", "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0000938 GARP complex;GO:1990745 EARP complex;GO:0005829 cytosol;GO:0016020 membrane", "go_biological_process": "GO:0015031 protein transport;GO:0006605 protein targeting;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling;GO:0007041 lysosomal transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BDC9-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BI49-1", "uniprot_id": [ { "id": "E1BI49_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BI49", "type": "external" } ], "mass": 73202.0, "length": 641, "protein_name": "alpha-1,2-Mannosidase", "gene_name": "MAN1A2", "organism": "Bovine", "refseq_name": "mannosyl-oligosaccharide 1,2-alpha-mannosidase IB", "refseq_ac": [ { "id": "NP_001193806", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193806", "type": "external" } ], "gene_names_uniprotkb": "MAN1A2", "gene_names_refseq": "MAN1A2", "protein_names_uniprotkb": "alpha-1,2-Mannosidase; 3.2.1.-", "protein_names_refseq": "mannosyl-oligosaccharide 1,2-alpha-mannosidase IB", "tax_id": 9913, "disease": "", "pathway": " (bta:532645); (R-BTA-964827)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system;GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0036503 ERAD pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BI49-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKB2-1", "uniprot_id": [ { "id": "E1BKB2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKB2", "type": "external" } ], "mass": 74581.0, "length": 657, "protein_name": "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase", "gene_name": "NGLY1", "organism": "Bovine", "refseq_name": "peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase", "refseq_ac": [ { "id": "NP_001179716", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179716", "type": "external" } ], "gene_names_uniprotkb": "NGLY1", "gene_names_refseq": "NGLY1", "protein_names_uniprotkb": "Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase; 3.5.1.52; N-glycanase 1; Peptide:N-glycanase", "protein_names_refseq": "peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase", "tax_id": 9913, "disease": "", "pathway": " (bta:533736); (R-BTA-532668)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.52", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.52", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "1.14.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-", "type": "external" } ], "go_molecular_function": "GO:0000224 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006516 glycoprotein catabolic process;GO:0030513 positive regulation of BMP signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BKB2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BBS9-1", "uniprot_id": [ { "id": "E1BBS9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BBS9", "type": "external" } ], "mass": 222560.0, "length": 1980, "protein_name": "Ciliary rootlet coiled-coil, rootletin", "gene_name": "CROCC", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CROCC", "gene_names_refseq": "", "protein_names_uniprotkb": "Ciliary rootlet coiled-coil, rootletin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003779 actin binding;GO:0005200 structural constituent of cytoskeleton;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005813 centrosome;GO:0035253 ciliary rootlet;GO:0001917 photoreceptor inner segment;GO:0005814 centriole;GO:0036064 ciliary basal body", "go_biological_process": "GO:0008104 intracellular protein localization;GO:0007098 centrosome cycle;GO:1903566 positive regulation of protein localization to cilium;GO:0010457 centriole-centriole cohesion;GO:0045724 positive regulation of cilium assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BBS9-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BAS6-1", "uniprot_id": [ { "id": "E1BAS6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BAS6", "type": "external" } ], "mass": 303247.0, "length": 2683, "protein_name": "Helicase senataxin", "gene_name": "SETX", "organism": "Bovine", "refseq_name": "probable helicase senataxin isoform X1", "refseq_ac": [ { "id": "XP_010808825", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010808825", "type": "external" } ], "gene_names_uniprotkb": "SETX", "gene_names_refseq": "SETX", "protein_names_uniprotkb": "Helicase senataxin; 3.6.4.12; 3.6.4.13; SEN1 homolog", "protein_names_refseq": "probable helicase senataxin isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:534284)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0003723 RNA binding;GO:0004386 helicase activity;GO:0001147 transcription termination site sequence-specific DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity", "go_cellular_component": "GO:0016604 nuclear body;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0030426 growth cone", "go_biological_process": "GO:0006369 termination of RNA polymerase II transcription;GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0007283 spermatogenesis;GO:0007399 nervous system development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BAS6-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJ25-1", "uniprot_id": [ { "id": "E1BJ25_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJ25", "type": "external" } ], "mass": 68480.0, "length": 645, "protein_name": "Forkhead box N1", "gene_name": "FOXN1", "organism": "Bovine", "refseq_name": "forkhead box protein N1 isoform X1", "refseq_ac": [ { "id": "XP_005220165", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005220165", "type": "external" } ], "gene_names_uniprotkb": "FOXN1", "gene_names_refseq": "FOXN1", "protein_names_uniprotkb": "Forkhead box N1", "protein_names_refseq": "forkhead box protein N1 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005634 nucleus", "go_biological_process": "GO:0002360 T cell lineage commitment;GO:0030858 positive regulation of epithelial cell differentiation;GO:1902232 regulation of positive thymic T cell selection;GO:0006351 DNA-templated transcription;GO:0048514 blood vessel morphogenesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BJ25-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BF60-1", "uniprot_id": [ { "id": "E1BF60_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BF60", "type": "external" } ], "mass": 43549.0, "length": 378, "protein_name": "Ubiquitin carboxyl-terminal hydrolase 50", "gene_name": "USP50", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "USP50", "gene_names_refseq": "", "protein_names_uniprotkb": "Ubiquitin carboxyl-terminal hydrolase 50; 3.4.19.12", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Regulates the inflammasome signaling pathway by deubiquitinating 'Lys-63'-linked polyubiquitination of the PYCARD/ASC adapter protein. Regulates the ubiquitination and stability of the ACE2 protein. Acts as a negative regulator of the G2/M checkpoint pathway, by preventing serine/threonine kinase WEE1 degradation, thereby repressing entry into mitosis following activation of the G2/M DNA damage checkpoint., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0014069 postsynaptic density;GO:0030496 midbody", "go_biological_process": "GO:0016579 protein deubiquitination;GO:0032731 positive regulation of interleukin-1 beta production;GO:1900227 positive regulation of NLRP3 inflammasome complex assembly;GO:0007265 Ras protein signal transduction;GO:0007032 endosome organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BF60-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BLQ3-1", "uniprot_id": [ { "id": "E1BLQ3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BLQ3", "type": "external" } ], "mass": 30193.0, "length": 281, "protein_name": "Activating transcription factor 5", "gene_name": "ATF5", "organism": "Bovine", "refseq_name": "cyclic AMP-dependent transcription factor ATF-5", "refseq_ac": [ { "id": "NP_001179351", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179351", "type": "external" } ], "gene_names_uniprotkb": "ATF5", "gene_names_refseq": "ATF5", "protein_names_uniprotkb": "Activating transcription factor 5", "protein_names_refseq": "cyclic AMP-dependent transcription factor ATF-5", "tax_id": 9913, "disease": "", "pathway": " (bta:515654)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0003682 chromatin binding;GO:0019900 kinase binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005667 transcription regulator complex", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042981 regulation of apoptotic process;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BLQ3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MD24-1", "uniprot_id": [ { "id": "F1MD24_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MD24", "type": "external" } ], "mass": 73102.0, "length": 664, "protein_name": "Sodium/glucose cotransporter 1", "gene_name": "SLC5A1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC5A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium/glucose cotransporter 1; High affinity sodium-glucose cotransporter; Solute carrier family 5 member 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-189200); (R-BTA-8981373)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008324 monoatomic cation transmembrane transporter activity;GO:0015293 symporter activity;GO:0005412 D-glucose:sodium symporter activity;GO:0005372 water transmembrane transporter activity;GO:0015371 galactose:sodium symporter activity", "go_cellular_component": "GO:0016324 apical plasma membrane;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm", "go_biological_process": "GO:0006814 sodium ion transport;GO:0035623 renal D-glucose absorption;GO:0035377 transepithelial water transport;GO:0098719 sodium ion import across plasma membrane;GO:0150104 transport across blood-brain barrier", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MD24-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BHY6-1", "uniprot_id": [ { "id": "E1BHY6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BHY6", "type": "external" } ], "mass": 64334.0, "length": 597, "protein_name": "Progranulin", "gene_name": "GRN", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "GRN", "gene_names_refseq": "", "protein_names_uniprotkb": "Progranulin; Acrogranin; Proepithelin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6798695)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005125 cytokine activity;GO:0051087 protein-folding chaperone binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005764 lysosome;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane", "go_biological_process": "GO:0050793 regulation of developmental process;GO:0051649 establishment of localization in cell;GO:0051130 positive regulation of cellular component organization;GO:0048680 positive regulation of axon regeneration;GO:1903979 negative regulation of microglial cell activation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BHY6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BDI3-1", "uniprot_id": [ { "id": "E1BDI3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BDI3", "type": "external" } ], "mass": 137108.0, "length": 1226, "protein_name": "DNA polymerase subunit gamma-1", "gene_name": "POLG", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "POLG", "gene_names_refseq": "", "protein_names_uniprotkb": "DNA polymerase subunit gamma-1; 2.7.7.7; 3'-5' exodeoxyribonuclease; 5'-deoxyribose-phosphate lyase; Mitochondrial DNA polymerase catalytic subunit; PolG-alpha", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9913635)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0002020 protease binding", "go_cellular_component": "GO:0042645 mitochondrial nucleoid;GO:0005760 gamma DNA polymerase complex;GO:0005739 mitochondrion;GO:0000262 mitochondrial chromosome", "go_biological_process": "GO:0006264 mitochondrial DNA replication;GO:0045004 DNA replication proofreading;GO:0006284 base-excision repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BDI3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MDE6-1", "uniprot_id": [ { "id": "F1MDE6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MDE6", "type": "external" } ], "mass": 83007.0, "length": 757, "protein_name": "Amyloid beta protein binding family B member 2", "gene_name": "APBB2; LOC132345566", "organism": "Bovine", "refseq_name": "amyloid beta precursor protein binding family B member 2 isoform X1", "refseq_ac": [ { "id": "XP_005207921", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005207921", "type": "external" } ], "gene_names_uniprotkb": "APBB2; LOC132345566; LOC132345566", "gene_names_refseq": "APBB2", "protein_names_uniprotkb": "Amyloid beta protein binding family B member 2", "protein_names_refseq": "amyloid beta precursor protein binding family B member 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the ribosome., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0003723 RNA binding;GO:0060090 molecular adaptor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0022625 cytosolic large ribosomal subunit;GO:0005634 nucleus;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0042254 ribosome biogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006939 smooth muscle contraction;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MDE6-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MBA3-1", "uniprot_id": [ { "id": "F1MBA3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MBA3", "type": "external" } ], "mass": 129866.0, "length": 1179, "protein_name": "Integrin alpha-2", "gene_name": "ITGA2", "organism": "Bovine", "refseq_name": "integrin alpha-2 precursor", "refseq_ac": [ { "id": "NP_001159971", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159971", "type": "external" } ], "gene_names_uniprotkb": "ITGA2", "gene_names_refseq": "ITGA2", "protein_names_uniprotkb": "Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; VLA-2 subunit alpha", "protein_names_refseq": "CD49 antigen-like family member B; GPIa; VLA-2 alpha chain; VLA-2 subunit alpha; collagen receptor; integrin alpha-2 precursor; integrin alpha-2; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); platelet membrane glycoprotein Ia", "tax_id": 9913, "disease": "", "pathway": " (bta:281872); (R-BTA-216083); (R-BTA-3000170); (R-BTA-3000178); (R-BTA-8874081)", "pathway_count": 5, "publication_count": 2, "publication_id_list": "16928957;17408410", "class_list": "", "function": "Both the gpIb-VWF interaction and the integrin alpha(2)beta(1)-collagen interaction contribute to platelet adhesion under high shear stress; integrin alpha(II)beta(1) makes a greater contribution to adhesion to type I collagen because less VWF is bound, [RefSeq, PubMed]; Flow induced alpha2beta1 activation in cells on collagen, but not on fibronectin or fibrinogen. Conversely, alpha5beta1 and alphavbeta3 are activated on fibronectin and fibrinogen, but not collagen., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0038023 signaling receptor activity", "go_cellular_component": "GO:0009986 cell surface;GO:0008305 integrin complex;GO:0034666 integrin alpha2-beta1 complex", "go_biological_process": "GO:0007155 cell adhesion;GO:0007229 integrin-mediated signaling pathway;GO:0098609 cell-cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.3, "record_id": "F1MBA3-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNM8-1", "uniprot_id": [ { "id": "E1BNM8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNM8", "type": "external" } ], "mass": 41534.0, "length": 379, "protein_name": "Wnt inhibitory factor 1", "gene_name": "WIF1", "organism": "Bovine", "refseq_name": "wnt inhibitory factor 1 isoform X1", "refseq_ac": [ { "id": "XP_005206695", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005206695", "type": "external" } ], "gene_names_uniprotkb": "WIF1", "gene_names_refseq": "WIF1", "protein_names_uniprotkb": "Wnt inhibitory factor 1", "protein_names_refseq": "wnt inhibitory factor 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005102 signaling receptor binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface", "go_biological_process": "GO:0016055 Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BNM8-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MDK3-1", "uniprot_id": [ { "id": "F1MDK3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MDK3", "type": "external" } ], "mass": 135541.0, "length": 1285, "protein_name": "Period circadian regulator 1", "gene_name": "PER1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PER1", "gene_names_refseq": "", "protein_names_uniprotkb": "Period circadian regulator 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-9932298)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 4, "predicted_n_glycosites": 0, "predicted_o_glycosites": 4, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 4, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0031625 ubiquitin protein ligase binding;GO:0019900 kinase binding;GO:0000976 transcription cis-regulatory region binding;GO:0031490 chromatin DNA binding;GO:0070888 E-box binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0048511 rhythmic process;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MDK3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BGF3-1", "uniprot_id": [ { "id": "E1BGF3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BGF3", "type": "external" } ], "mass": 209778.0, "length": 2049, "protein_name": "Host cell factor 1", "gene_name": "HCFC1", "organism": "Bovine", "refseq_name": "host cell factor 1 isoform X1", "refseq_ac": [ { "id": "XP_015317010", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_015317010", "type": "external" } ], "gene_names_uniprotkb": "HCFC1", "gene_names_refseq": "HCFC1", "protein_names_uniprotkb": "Host cell factor 1; C1 factor", "protein_names_refseq": "host cell factor 1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:512908); (R-BTA-3214847); (R-BTA-5689603); (R-BTA-9772755)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:0140297 DNA-binding transcription factor binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0043025 neuronal cell body;GO:0035097 histone methyltransferase complex;GO:0048188 Set1C/COMPASS complex", "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0019046 release from viral latency;GO:0006338 chromatin remodeling;GO:0010628 positive regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BGF3-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCH6-1", "uniprot_id": [ { "id": "ISPD_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCH6", "type": "external" } ], "mass": 49510.0, "length": 445, "protein_name": "D-ribitol-5-phosphate cytidylyltransferase", "gene_name": "CRPPA", "organism": "Bovine", "refseq_name": "D-ribitol-5-phosphate cytidylyltransferase isoform X4", "refseq_ac": [ { "id": "XP_002686725", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002686725", "type": "external" } ], "gene_names_uniprotkb": "CRPPA; ISPD", "gene_names_refseq": "CRPPA", "protein_names_uniprotkb": "D-ribitol-5-phosphate cytidylyltransferase; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; 2.7.7.40; Isoprenoid synthase domain-containing protein", "protein_names_refseq": "D-ribitol-5-phosphate cytidylyltransferase isoform X4", "tax_id": 9913, "disease": "", "pathway": " (bta:104968457); (R-BTA-9939291)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "Cytidylyltransferase required for protein O-linked mannosylation (By similarity). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (By similarity). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively. Not involved in dolichol production (By similarity)., [UniProtKB, UniProtKB]; Cytidylyltransferase required for protein O-linked mannosylation. Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate. CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively. Not involved in dolichol production., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.40", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.40", "type": "external" } ], "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0047349 D-ribitol-5-phosphate cytidylyltransferase activity;GO:0070567 cytidylyltransferase activity", "go_cellular_component": "GO:0005829 cytosol", "go_biological_process": "GO:0035269 protein O-linked glycosylation via mannose;GO:0008299 isoprenoid biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BCH6-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BLZ4-1", "uniprot_id": [ { "id": "ZFY26_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BLZ4", "type": "external" } ], "mass": 280355.0, "length": 2515, "protein_name": "Zinc finger FYVE domain-containing protein 26", "gene_name": "ZFYVE26", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ZFYVE26", "gene_names_refseq": "", "protein_names_uniprotkb": "Zinc finger FYVE domain-containing protein 26", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Phosphatidylinositol 3-phosphate-binding protein required for the abscission step in cytokinesis: recruited to the midbody during cytokinesis and acts as a regulator of abscission. May also be required for efficient homologous recombination DNA double-strand break repair (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 5, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0032266 phosphatidylinositol-3-phosphate binding;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005813 centrosome;GO:0030496 midbody;GO:0005769 early endosome;GO:0005764 lysosome;GO:0005770 late endosome", "go_biological_process": "GO:0007040 lysosome organization;GO:0000281 mitotic cytokinesis;GO:0000724 double-strand break repair via homologous recombination;GO:0032465 regulation of cytokinesis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BLZ4-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001001.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BI01-1", "uniprot_id": [ { "id": "E1BI01_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BI01", "type": "external" } ], "mass": 52901.0, "length": 473, "protein_name": "Dual specificity mitogen-activated protein kinase kinase 5", "gene_name": "MAP2K5", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "MAP2K5", "gene_names_refseq": "", "protein_names_uniprotkb": "Dual specificity mitogen-activated protein kinase kinase 5; 2.7.12.2; MAPK/ERK kinase 5", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": 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kinase activity", "go_cellular_component": "GO:0005819 spindle", "go_biological_process": "GO:0048009 insulin-like growth factor receptor signaling pathway;GO:0000165 MAPK cascade", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BI01-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BL69-1", "uniprot_id": [ { "id": "E1BL69_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BL69", "type": "external" } ], "mass": 67520.0, "length": 587, "protein_name": "REC8 meiotic recombination protein", "gene_name": "REC8", "organism": "Bovine", "refseq_name": "meiotic recombination protein REC8 homolog", "refseq_ac": [ { "id": "NP_001178217", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178217", "type": "external" } ], "gene_names_uniprotkb": "REC8", "gene_names_refseq": "REC8", "protein_names_uniprotkb": "REC8 meiotic recombination protein", "protein_names_refseq": "meiotic recombination protein REC8 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:516291)", "pathway_count": 1, "publication_count": 1, "publication_id_list": "22844258", "class_list": "", "function": "We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, 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binding;GO:0046872 metal ion binding;GO:0000166 nucleotide binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0070034 telomerase RNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000176 nuclear exosome (RNase complex);GO:0005829 cytosol", "go_biological_process": "GO:0006281 DNA repair;GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0019219 regulation of nucleobase-containing compound metabolic process;GO:0071028 nuclear mRNA surveillance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BMZ5-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MBM5-1", "uniprot_id": [ { "id": "F1MBM5_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MBM5", "type": "external" } ], "mass": 37913.0, "length": 337, "protein_name": "Torsin", "gene_name": "TOR1B", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TOR1B", "gene_names_refseq": "", "protein_names_uniprotkb": "Torsin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8856825)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, 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"type": "external" }, { "id": "7.2.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.1.5", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "3.6.4.10", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" }, { "id": "5.6.2.-", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-", "type": "external" }, { "id": "2.7.4.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "3.6.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15", "type": "external" }, { "id": "7.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1", "type": "external" }, { "id": "3.1.3.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1", "type": "external" }, { "id": "3.9.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1", "type": "external" }, { "id": "5.6.2.5", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5", "type": "external" }, { "id": "3.4.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-", "type": "external" }, { "id": "3.6.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-", "type": "external" }, { "id": "3.6.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-", "type": "external" }, { "id": "5.6.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.7", "type": "external" }, { "id": "3.1.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-", "type": "external" }, { "id": "3.4.21.53", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0042802 identical protein binding;GO:0019894 kinesin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005788 endoplasmic reticulum lumen;GO:0005635 nuclear envelope", "go_biological_process": "GO:0034504 protein localization to nucleus;GO:0007029 endoplasmic reticulum organization;GO:0071763 nuclear membrane organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MBM5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BPQ8-1", "uniprot_id": [ { "id": "E1BPQ8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BPQ8", "type": "external" } ], "mass": 60577.0, "length": 531, "protein_name": "Parafibromin", "gene_name": "CDC73", "organism": "Bovine", "refseq_name": "parafibromin", "refseq_ac": [ { "id": "NP_001178201", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178201", "type": "external" } ], "gene_names_uniprotkb": "CDC73", "gene_names_refseq": "CDC73", "protein_names_uniprotkb": "Parafibromin; Cell division cycle protein 73 homolog", "protein_names_refseq": "cell division cycle 73, Paf1/RNA polymerase II complex component, homolog; hyperparathyroidism 2 homolog; parafibromin", "tax_id": 9913, "disease": "", "pathway": " (bta:100139547); (R-BTA-201722); (R-BTA-5632684); (R-BTA-674695); (R-BTA-75955); (R-BTA-8866654); (R-BTA-9943411)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0000993 RNA polymerase II complex binding", "go_cellular_component": "GO:0016593 Cdc73/Paf1 complex", "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II;GO:0050680 negative regulation of epithelial cell proliferation;GO:0071222 cellular response to lipopolysaccharide;GO:0048147 negative regulation of fibroblast proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BPQ8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCZ0-1", "uniprot_id": [ { "id": "E1BCZ0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCZ0", "type": "external" } ], "mass": 138102.0, "length": 1224, "protein_name": "DNA-directed RNA polymerase", "gene_name": "POLRMT", "organism": "Bovine", "refseq_name": "DNA-directed RNA polymerase, mitochondrial", "refseq_ac": [ { "id": "NP_001192480", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192480", "type": "external" } ], "gene_names_uniprotkb": "POLRMT", "gene_names_refseq": "POLRMT", "protein_names_uniprotkb": "DNA-directed RNA polymerase; 2.7.7.6", "protein_names_refseq": "DNA-directed RNA polymerase, mitochondrial; polymerase (RNA) mitochondrial (DNA directed)", "tax_id": 9913, "disease": "", "pathway": " (bta:504757); (R-BTA-163282); (R-BTA-9913635)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB, UniProtKB]; DNA-dependent RNA polymerase catalyzes the transcription of mitochondrial DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA. In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand. Has DNA primase activity. Catalyzes the synthesis of short RNA primers that are necessary for the initiation of lagging-strand DNA synthesis from the origin of light-strand DNA replication (OriL)., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6", "type": "external" }, { "id": "3.1.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-", "type": "external" }, { "id": "2.7.7.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.1.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0003899 DNA-directed RNA polymerase activity;GO:0043565 sequence-specific DNA binding;GO:0001018 mitochondrial promoter sequence-specific DNA binding;GO:0000175 3'-5'-RNA exonuclease activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0000428 DNA-directed RNA polymerase complex;GO:0034245 mitochondrial DNA-directed RNA polymerase complex;GO:0042645 mitochondrial nucleoid", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006391 transcription initiation at mitochondrial promoter;GO:0006390 mitochondrial transcription", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCZ0-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BIU7-1", "uniprot_id": [ { "id": "E1BIU7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BIU7", "type": "external" } ], "mass": 176321.0, "length": 1617, "protein_name": "Tyrosine-protein phosphatase non-receptor type 23", "gene_name": "PTPN23", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PTPN23", "gene_names_refseq": "", "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 23; 3.1.3.48", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Plays a role in sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs) via its interaction with the ESCRT-I complex (endosomal sorting complex required for transport I), and possibly also other ESCRT complexes. May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004725 protein tyrosine phosphatase activity;GO:0019901 protein kinase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0016604 nuclear body", "go_biological_process": "GO:0015031 protein transport;GO:0030030 cell projection organization;GO:0010633 negative regulation of epithelial cell migration;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:1903393 positive regulation of adherens junction organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BIU7-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BPY3-1", "uniprot_id": [ { "id": "E1BPY3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BPY3", "type": "external" } ], "mass": 65245.0, "length": 586, "protein_name": "O-phosphoseryl-tRNA(Sec) selenium transferase", "gene_name": "SEPSECS", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SEPSECS", "gene_names_refseq": "", "protein_names_uniprotkb": "O-phosphoseryl-tRNA(Sec) selenium transferase; 2.9.1.2; Selenocysteine synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.9.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.9.1.2", "type": "external" } ], "go_molecular_function": "GO:0000049 tRNA binding;GO:0098621 O-phosphoseryl-tRNA(Sec) selenium transferase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0005829 cytosol", "go_biological_process": "GO:0006412 translation;GO:0001717 conversion of seryl-tRNAsec to selenocys-tRNAsec;GO:0001514 selenocysteine incorporation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BPY3-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEP6-1", "uniprot_id": [ { "id": "F1MEP6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEP6", "type": "external" } ], "mass": 34869.0, "length": 314, "protein_name": "Epithelial cell adhesion molecule", "gene_name": "EPCAM", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "EPCAM", "gene_names_refseq": "", "protein_names_uniprotkb": "Epithelial cell adhesion molecule; Tumor-associated calcium signal transducer 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-202733)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0098641 cadherin binding involved in cell-cell adhesion", "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0016328 lateral plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane", "go_biological_process": "GO:2000648 positive regulation of stem cell proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation;GO:0001657 ureteric bud development;GO:0023019 signal transduction involved in regulation of gene expression", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MEP6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BGJ7-1", "uniprot_id": [ { "id": "E1BGJ7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BGJ7", "type": "external" } ], "mass": 95749.0, "length": 834, "protein_name": "V-type proton ATPase subunit a", "gene_name": "ATP6V0A4; SVOPL", "organism": "Bovine", "refseq_name": "V-type proton ATPase 116 kDa subunit a 4", "refseq_ac": [ { "id": "NP_001192780", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192780", "type": "external" } ], "gene_names_uniprotkb": "ATP6V0A4; SVOPL; ATP6V0A4", "gene_names_refseq": "ATP6V0A4", "protein_names_uniprotkb": "V-type proton ATPase subunit a", "protein_names_refseq": "V-type proton ATPase 116 kDa subunit a 4", "tax_id": 9913, "disease": "", "pathway": " (bta:518832); (bta:518974); (R-BTA-1222556); (R-BTA-77387); (R-BTA-917977); (R-BTA-983712)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0046961 proton-transporting ATPase activity, rotational mechanism;GO:0051117 ATPase binding", "go_cellular_component": "GO:0016020 membrane;GO:0012505 endomembrane system;GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain;GO:0005768 endosome;GO:0005886 plasma membrane", "go_biological_process": "GO:0007605 sensory perception of sound;GO:0001503 ossification;GO:0097254 renal tubular secretion;GO:0097401 synaptic vesicle lumen acidification;GO:0007035 vacuolar acidification", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BGJ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MCQ1-1", "uniprot_id": [ { "id": "F1MCQ1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MCQ1", "type": "external" } ], "mass": 42775.0, "length": 389, "protein_name": "Arrestin-C", "gene_name": "ARR3", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ARR3", "gene_names_refseq": "", "protein_names_uniprotkb": "Arrestin-C; Cone arrestin; Retinal cone arrestin-3", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "May play a role in an as yet undefined retina-specific signal transduction. Could bind to photoactivated-phosphorylated red/green opsins., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0051219 phosphoprotein binding;GO:0002046 opsin binding", "go_cellular_component": "GO:0001750 photoreceptor outer segment;GO:0045202 synapse;GO:0001917 photoreceptor inner segment", "go_biological_process": "GO:0007165 signal transduction;GO:0007601 visual perception;GO:0002031 G protein-coupled receptor internalization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MCQ1-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BHY0-1", "uniprot_id": [ { "id": "E1BHY0_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BHY0", "type": "external" } ], "mass": 80950.0, "length": 741, "protein_name": "Solute carrier family 26 member 5", "gene_name": "SLC26A5", "organism": "Bovine", "refseq_name": "prestin", "refseq_ac": [ { "id": "NP_001179807", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179807", "type": "external" } ], "gene_names_uniprotkb": "SLC26A5", "gene_names_refseq": "SLC26A5", "protein_names_uniprotkb": "Solute carrier family 26 member 5", "protein_names_refseq": "prestin", "tax_id": 9913, "disease": "", "pathway": " (bta:536341)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008271 secondary active sulfate transmembrane transporter activity;GO:0042803 protein homodimerization activity;GO:0030507 spectrin binding;GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0016328 lateral plasma membrane;GO:0120249 lateral wall of outer hair cell", "go_biological_process": "GO:0055085 transmembrane transport;GO:0019532 oxalate transport;GO:0007605 sensory perception of sound;GO:1902476 chloride transmembrane transport;GO:1902358 sulfate transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BHY0-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BIX2-1", "uniprot_id": [ { "id": "E1BIX2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BIX2", "type": "external" } ], "mass": 194119.0, "length": 1717, "protein_name": "DNA-directed RNA polymerase subunit", "gene_name": "POLR1A", "organism": "Bovine", "refseq_name": "DNA-directed RNA polymerase I subunit RPA1", "refseq_ac": [ { "id": "NP_001179805", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179805", "type": "external" } ], "gene_names_uniprotkb": "POLR1A", "gene_names_refseq": "POLR1A", "protein_names_uniprotkb": "DNA-directed RNA polymerase subunit; 2.7.7.6", "protein_names_refseq": "DNA-directed RNA polymerase I subunit RPA1; polymerase (RNA) I polypeptide A, 194kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:536316); (R-BTA-5250924); (R-BTA-73762); (R-BTA-73772); (R-BTA-73863)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" 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"0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BE98-1", "uniprot_id": [ { "id": "E1BE98_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BE98", "type": "external" } ], "mass": 123142.0, "length": 1071, "protein_name": "Exportin-1", "gene_name": "XPO1", "organism": "Bovine", "refseq_name": "exportin-1", "refseq_ac": [ { "id": "NP_001179190", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179190", "type": "external" } ], "gene_names_uniprotkb": "XPO1", "gene_names_refseq": "XPO1", "protein_names_uniprotkb": "Exportin-1; Chromosome region maintenance 1 protein homolog", "protein_names_refseq": "exportin 1 (CRM1 homolog, yeast); exportin-1", "tax_id": 9913, "disease": "", "pathway": " (bta:510568); (R-BTA-141430); (R-BTA-141444); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-3769402); (R-BTA-450520); (R-BTA-5663220); (R-BTA-5687128); (R-BTA-69273); (R-BTA-9634638); (R-BTA-9648025); (R-BTA-9707616); 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"ec_number_list": [ { "id": "2.4.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-", "type": "external" }, { "id": "2.4.1.275", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275", "type": "external" }, { "id": "2.4.1.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22", "type": "external" }, { "id": "2.4.1.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38", "type": "external" }, { "id": "2.4.1.90", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0032580 Golgi cisterna membrane;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0005975 carbohydrate metabolic process;GO:0006665 sphingolipid metabolic process;GO:0009101 glycoprotein biosynthetic process;GO:0006688 glycosphingolipid biosynthetic process;GO:0022010 central nervous system myelination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCQ2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJM5-1", "uniprot_id": [ { "id": "E1BJM5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJM5", "type": "external" } ], "mass": 140104.0, "length": 1317, "protein_name": "PAS domain-containing serine/threonine-protein kinase", "gene_name": "MTERF4", "organism": "Bovine", "refseq_name": "transcription termination factor 4, mitochondrial isoform X1", "refseq_ac": [ { "id": "XP_010802248", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010802248", "type": "external" } ], "gene_names_uniprotkb": "MTERF4", "gene_names_refseq": "MTERF4; MTERFD2", "protein_names_uniprotkb": "PAS domain-containing serine/threonine-protein kinase; 2.7.11.1", "protein_names_refseq": "transcription termination factor 4, mitochondrial isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: regulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate in respiratory regulation., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008289 lipid binding;GO:0035091 phosphatidylinositol binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol", "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0035556 intracellular signal transduction;GO:0097009 energy homeostasis;GO:0043576 regulation of respiratory gaseous exchange;GO:0070092 regulation of glucagon secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BJM5-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKR6-1", "uniprot_id": [ { "id": "E1BKR6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKR6", "type": "external" } ], "mass": 177125.0, "length": 1583, "protein_name": "ATP binding cassette subfamily C member 8", "gene_name": "ABCC8", "organism": "Bovine", "refseq_name": "ATP-binding cassette sub-family C member 8 isoform X2", "refseq_ac": [ { "id": "XP_010810804", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_010810804", "type": "external" } ], "gene_names_uniprotkb": "ABCC8", "gene_names_refseq": "ABCC8", "protein_names_uniprotkb": "ATP binding cassette subfamily C member 8", "protein_names_refseq": "ATP-binding cassette sub-family C member 8 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1296025); (R-BTA-422356)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", 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0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0008281 sulfonylurea receptor activity;GO:0140359 ABC-type transporter activity;GO:0043531 ADP binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0032991 protein-containing complex;GO:0008282 inward rectifying potassium channel", "go_biological_process": "GO:0033198 response to ATP;GO:0071805 potassium ion transmembrane transport;GO:0055085 transmembrane transport;GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0046676 negative regulation of insulin secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BKR6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCU7-1", "uniprot_id": [ { "id": "E1BCU7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCU7", "type": "external" } ], "mass": 72263.0, "length": 643, "protein_name": "RNA N(6)-adenosine-methyltransferase METTL16", "gene_name": "METTL16", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "METTL16", "gene_names_refseq": "", "protein_names_uniprotkb": "RNA N(6)-adenosine-methyltransferase METTL16; 2.1.1.346; 2.1.1.348; Methyltransferase 10 domain-containing protein; Methyltransferase-like protein 16; RNA N(6)-adenosine-methyltransferase mettl16; U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003723 RNA binding;GO:0120048 U6 snRNA (adenine-(43)-N(6))-methyltransferase activity;GO:0035613 RNA stem-loop binding;GO:0030629 U6 snRNA 3'-end binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005654 nucleoplasm", "go_biological_process": "GO:0006397 mRNA processing;GO:0043488 regulation of mRNA stability;GO:0009451 RNA modification;GO:0032259 methylation;GO:0061014 positive regulation of mRNA catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCU7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BHT9-1", "uniprot_id": [ { "id": "E1BHT9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BHT9", "type": "external" } ], "mass": 60832.0, "length": 547, "protein_name": "Tubby-like protein", "gene_name": "TULP1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TULP1", "gene_names_refseq": "", "protein_names_uniprotkb": "Tubby-like protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005929 cilium", "go_biological_process": "GO:0016358 dendrite development;GO:0045494 photoreceptor cell maintenance;GO:0050766 positive regulation of phagocytosis;GO:0061512 protein localization to cilium;GO:0050908 detection of light stimulus involved in visual perception", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BHT9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJ49-1", "uniprot_id": [ { "id": "E1BJ49_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJ49", "type": "external" } ], "mass": 76385.0, "length": 686, "protein_name": "Complement C1s subcomponent", "gene_name": "MASP2", "organism": "Bovine", "refseq_name": "mannan-binding lectin serine protease 2 precursor", "refseq_ac": [ { "id": "NP_001179001", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179001", "type": "external" } ], "gene_names_uniprotkb": "MASP2", "gene_names_refseq": "MASP2", "protein_names_uniprotkb": "Complement C1s subcomponent; 3.4.21.104; Complement component 1 subcomponent s; MBL-associated serine protease 2; Mannan-binding lectin serine protease 2; Mannose-binding protein-associated serine protease 2", "protein_names_refseq": "mannan binding lectin serine peptidase 2; mannan-binding lectin serine protease 2 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:505819); (R-BTA-166662); (R-BTA-2855086)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "25729929", "class_list": "", "function": "Precursor of a serum protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface. MASP2 is cleaved and activated by MASP1 in response to lectin-binding to pathogen carbohydrates. Can activate prothrombin to thrombin., [UniProtKB, UniProtKB]; Serine protease component of the lectin complement pathway, which catalyzes cleavage and activation of C2 and C4, the next components of the complement pathway., [UniProtKB, UniProtKB]; The combination of the BMAP-28 genotype CC and the MASP-2 genotype GG was the best one, in which the somatic cell score was significantly lower than those in the other combinations. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 1, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.4.21.104", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.104", "type": "external" } ], "go_molecular_function": "GO:0005509 calcium ion binding;GO:0008233 peptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0048306 calcium-dependent protein binding;GO:0001855 complement component C4b binding", "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006508 proteolysis;GO:0045087 innate immune response;GO:0006958 complement activation, classical pathway;GO:0001867 complement activation, lectin pathway", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BJ49-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000001.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MBL9-1", "uniprot_id": [ { "id": "F1MBL9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MBL9", "type": "external" } ], "mass": 36411.0, "length": 312, "protein_name": "Speedy/RINGO cell cycle regulator family member A", "gene_name": "SPDYA", "organism": "Bovine", "refseq_name": "speedy protein A isoform X2", "refseq_ac": [ { "id": "XP_059747493", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059747493", "type": "external" } ], "gene_names_uniprotkb": "SPDYA", "gene_names_refseq": "SPDYA", "protein_names_uniprotkb": "Speedy/RINGO cell cycle regulator family member A", "protein_names_refseq": "speedy protein A isoform X2", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, 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"go_molecular_function": "GO:0019901 protein kinase binding;GO:0030295 protein kinase activator activity", "go_cellular_component": "GO:0005654 nucleoplasm", "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0006974 DNA damage response;GO:0000082 G1/S transition of mitotic cell cycle", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MBL9-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MCQ6-1", "uniprot_id": [ { "id": "F1MCQ6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MCQ6", "type": "external" } ], "mass": 128713.0, "length": 1133, "protein_name": "Inositol polyphosphate-5-phosphatase F", "gene_name": "INPP5F", "organism": "Bovine", "refseq_name": "phosphatidylinositide phosphatase SAC2 isoform X1", "refseq_ac": [ { "id": "XP_024841730", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024841730", "type": "external" } ], "gene_names_uniprotkb": "INPP5F", "gene_names_refseq": "INPP5F", "protein_names_uniprotkb": "Inositol polyphosphate-5-phosphatase F", "protein_names_refseq": "phosphatidylinositide phosphatase SAC2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:539889); (R-BTA-1660516)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.3.64", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64", "type": "external" }, { "id": "3.1.3.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-", "type": "external" }, { "id": "3.1.3.95", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95", "type": "external" }, { "id": "3.1.3.36", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36", "type": "external" } ], "go_molecular_function": "GO:0016791 phosphatase activity;GO:0042803 protein homodimerization activity;GO:0034595 phosphatidylinositol phosphate 5-phosphatase activity;GO:0052833 inositol monophosphate 4-phosphatase activity;GO:0043812 phosphatidylinositol-4-phosphate phosphatase activity", "go_cellular_component": "GO:0005769 early endosome;GO:0005905 clathrin-coated pit;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body", "go_biological_process": "GO:0008344 adult locomotory behavior;GO:2000145 regulation of cell motility;GO:0001921 positive regulation of receptor recycling;GO:0072583 clathrin-dependent endocytosis;GO:0046856 phosphatidylinositol dephosphorylation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MCQ6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BHH1-1", "uniprot_id": [ { "id": "E1BHH1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BHH1", "type": "external" } ], "mass": 63147.0, "length": 575, "protein_name": "DNA polymerase", "gene_name": "POLL", "organism": "Bovine", "refseq_name": "DNA polymerase lambda", "refseq_ac": [ { "id": "NP_001179488", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179488", "type": "external" } ], "gene_names_uniprotkb": "POLL", "gene_names_refseq": "POLL", "protein_names_uniprotkb": "DNA polymerase; 2.7.7.7", "protein_names_refseq": "DNA polymerase lambda; polymerase (DNA directed), lambda; polymerase (DNA) lambda", "tax_id": 9913, "disease": "", "pathway": " (bta:522307); (R-BTA-5693571)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "2.7.7.49", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.7.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.31", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.7.102", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.102", "type": "external" }, { "id": "4.2.99.-", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-", "type": "external" } ], "go_molecular_function": "GO:0003887 DNA-directed DNA polymerase activity;GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0016829 lyase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break", "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0006287 base-excision repair, gap-filling;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BHH1-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKJ7-1", "uniprot_id": [ { "id": "E1BKJ7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKJ7", "type": "external" } ], "mass": 63478.0, "length": 577, "protein_name": "Insulin-like growth factor 2 mRNA-binding protein 1", "gene_name": "IGF2BP1", "organism": "Bovine", "refseq_name": "insulin-like growth factor 2 mRNA-binding protein 1", "refseq_ac": [ { "id": "NP_001179383", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179383", "type": "external" } ], "gene_names_uniprotkb": "IGF2BP1", "gene_names_refseq": "IGF2BP1", "protein_names_uniprotkb": "Insulin-like growth factor 2 mRNA-binding protein 1; IGF-II mRNA-binding protein 1; VICKZ family member 1", "protein_names_refseq": "insulin-like growth factor 2 mRNA-binding protein 1", "tax_id": 9913, "disease": "", "pathway": " (bta:516853)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003730 mRNA 3'-UTR binding;GO:0045182 translation regulator activity;GO:0048027 mRNA 5'-UTR binding;GO:1990247 N6-methyladenosine-containing RNA reader activity", "go_cellular_component": "GO:0005634 nucleus;GO:0030027 lamellipodium;GO:0030426 growth cone;GO:0048471 perinuclear region of cytoplasm;GO:0030175 filopodium", "go_biological_process": "GO:0006417 regulation of translation;GO:0051028 mRNA transport;GO:0010610 regulation of mRNA stability involved in response to stress;GO:0070934 CRD-mediated mRNA stabilization;GO:2000767 positive regulation of cytoplasmic translation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BKJ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BGQ7-1", "uniprot_id": [ { "id": "E1BGQ7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BGQ7", "type": "external" } ], "mass": 60291.0, "length": 533, "protein_name": "Neuropilin and tolloid-like protein 1", "gene_name": "NETO1", "organism": "Bovine", "refseq_name": "neuropilin and tolloid-like protein 1 precursor", "refseq_ac": [ { "id": "NP_001179623", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179623", "type": "external" } ], "gene_names_uniprotkb": "NETO1", "gene_names_refseq": "NETO1", "protein_names_uniprotkb": "Neuropilin and tolloid-like protein 1; Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1", "protein_names_refseq": "neuropilin (NRP) and tolloid (TLL)-like 1; neuropilin and tolloid-like protein 1 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:530407)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0035255 ionotropic glutamate receptor binding", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:1904115 axon cytoplasm;GO:0060076 excitatory synapse;GO:0098839 postsynaptic density membrane;GO:0098685 Schaffer collateral - CA1 synapse", "go_biological_process": "GO:0007613 memory;GO:0008542 visual learning;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane;GO:0099645 neurotransmitter receptor localization to postsynaptic specialization membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BGQ7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCN3-1", "uniprot_id": [ { "id": "E1BCN3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCN3", "type": "external" } ], "mass": 82356.0, "length": 747, "protein_name": "Protein-arginine deiminase type-4", "gene_name": "PADI4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PADI4", "gene_names_refseq": "", "protein_names_uniprotkb": "Protein-arginine deiminase type-4; 3.5.3.15; Peptidylarginine deiminase IV; Protein-arginine deiminase type IV", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3247509)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 0, "predicted_o_glycosites": 2, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.3.15", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.3.15", "type": "external" } ], "go_molecular_function": "GO:0004668 protein-arginine deiminase activity;GO:0005509 calcium ion binding;GO:0042802 identical protein binding;GO:0140794 histone arginine deiminase activity;GO:0140795 histone H3R2 arginine deiminase activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0032991 protein-containing complex", "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0043687 post-translational protein modification;GO:0045087 innate immune response;GO:0019827 stem cell population maintenance", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCN3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BIN2-1", "uniprot_id": [ { "id": "E1BIN2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BIN2", "type": "external" } ], "mass": 105490.0, "length": 957, "protein_name": "Anion exchange protein", "gene_name": "SLC4A9", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC4A9", "gene_names_refseq": "", "protein_names_uniprotkb": "Anion exchange protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-425381)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0140900 chloride:bicarbonate antiporter activity;GO:0008510 sodium:bicarbonate symporter activity;GO:0140892 sodium,bicarbonate:chloride antiporter activity", "go_cellular_component": "GO:0016323 basolateral plasma membrane;GO:0005886 plasma membrane;GO:0045177 apical part of cell", "go_biological_process": "GO:0046541 saliva secretion;GO:0055085 transmembrane transport;GO:0015701 bicarbonate transport;GO:0051453 regulation of intracellular pH", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BIN2-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MCT1-1", "uniprot_id": [ { "id": "F1MCT1_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MCT1", "type": "external" } ], "mass": 106379.0, "length": 965, "protein_name": "Proprotein convertase subtilisin/kexin type 6", "gene_name": "PCSK6", "organism": "Bovine", "refseq_name": "proprotein convertase subtilisin/kexin type 6 isoform X1", "refseq_ac": [ { "id": "XP_024837782", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024837782", "type": "external" } ], "gene_names_uniprotkb": "PCSK6", "gene_names_refseq": "PCSK6", "protein_names_uniprotkb": "Proprotein convertase subtilisin/kexin type 6; Paired basic amino acid cleaving enzyme 4; Subtilisin-like proprotein convertase 4; Subtilisin/kexin-like protease PACE4", "protein_names_refseq": "proprotein convertase subtilisin/kexin type 6 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:524684); (R-BTA-167060); (R-BTA-8963889); (R-BTA-9768727)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0048406 nerve growth factor binding;GO:0008201 heparin binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0009986 cell surface;GO:0016020 membrane;GO:0031012 extracellular matrix", "go_biological_process": "GO:0016486 peptide hormone processing;GO:0032902 nerve growth factor production;GO:0032940 secretion by cell;GO:0009100 glycoprotein metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MCT1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BHJ4-1", "uniprot_id": [ { "id": "CP26B_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BHJ4", "type": "external" } ], "mass": 57414.0, "length": 512, "protein_name": "Cytochrome P450 26B1", "gene_name": "CYP26B1", "organism": "Bovine", "refseq_name": "cytochrome P450 26B1", "refseq_ac": [ { "id": "NP_001179722", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179722", "type": "external" } ], "gene_names_uniprotkb": "CYP26B1", "gene_names_refseq": "CYP26B1", "protein_names_uniprotkb": "Cytochrome P450 26B1; 1.14.13.-", "protein_names_refseq": "cytochrome P450 26B1; cytochrome P450, family 26, subfamily B, polypeptide 1", "tax_id": 9913, "disease": "", "pathway": " (bta:540868); (R-BTA-211916); (R-BTA-5365859)", "pathway_count": 3, "publication_count": 1, "publication_id_list": "19393038", "class_list": "", "function": "A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (By similarity). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (By similarity). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (By similarity). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (By similarity). Involved in the convertion of atRA to all-trans-4-oxo-RA. Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (By similarity). Shows preference for the following substrates: atRA > 9-cis-RA > 13-cis-RA (By similarity). Plays a central role in germ cell development: acts by degrading RAs in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis. Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry. Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints. Essential for postnatal survival (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Also has a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.14.13.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.-", "type": "external" } ], "go_molecular_function": "GO:0008401 retinoic acid 4-hydroxylase activity;GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen;GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0001972 retinoic acid binding", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0071300 cellular response to retinoic acid;GO:0007417 central nervous system development;GO:0042573 retinoic acid metabolic process;GO:0006805 xenobiotic metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BHJ4-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BC50-1", "uniprot_id": [ { "id": "E1BC50_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BC50", "type": "external" } ], "mass": 135560.0, "length": 1207, "protein_name": "ADAM metallopeptidase with thrombospondin type 1 motif 3", "gene_name": "ADAMTS3", "organism": "Bovine", "refseq_name": "A disintegrin and metalloproteinase with thrombospondin motifs 3 precursor", "refseq_ac": [ { "id": "NP_001179726", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179726", "type": "external" } ], "gene_names_uniprotkb": "ADAMTS3", "gene_names_refseq": "ADAMTS3", "protein_names_uniprotkb": "ADAM metallopeptidase with thrombospondin type 1 motif 3", "protein_names_refseq": "A disintegrin and metalloproteinase with thrombospondin motifs 3 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:534082); (R-BTA-1650814); (R-BTA-5173214)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0046872 metal ion binding", "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix", "go_biological_process": "GO:0006508 proteolysis;GO:0030199 collagen fibril organization;GO:0016485 protein processing;GO:0030198 extracellular matrix organization;GO:0010573 vascular endothelial growth factor production", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BC50-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BMP9-1", "uniprot_id": [ { "id": "E1BMP9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BMP9", "type": "external" } ], "mass": 69876.0, "length": 617, "protein_name": "Tyrosine-protein kinase", "gene_name": "ZAP70", "organism": "Bovine", "refseq_name": "tyrosine-protein kinase ZAP-70", "refseq_ac": [ { "id": "NP_001179946", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179946", "type": "external" } ], "gene_names_uniprotkb": "ZAP70", "gene_names_refseq": "ZAP70", "protein_names_uniprotkb": "Tyrosine-protein kinase; 2.7.10.2", "protein_names_refseq": "tyrosine-protein kinase ZAP-70; zeta-chain (TCR) associated protein kinase 70kDa", "tax_id": 9913, "disease": "", "pathway": " (bta:504509); (R-BTA-202430); (R-BTA-202433); (R-BTA-9013407)", "pathway_count": 4, "publication_count": 1, "publication_id_list": "26163934", "class_list": "", "function": "The surface expression of CTLA-4 was increased in subclinical stages of paratuberculosis infection while levels of ZAP-70 were decreased in CD4+ T cells of both subclinical and clinical animals, indicating a change in T cell phenotype with disease state., [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.1.1.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.13", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "3.6.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6", "type": "external" }, { "id": "2.3.1.168", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168", "type": "external" }, { "id": "2.3.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" }, { "id": "3.6.5.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-", "type": "external" } ], "go_molecular_function": "GO:0001784 phosphotyrosine residue binding;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0004713 protein tyrosine kinase activity", "go_cellular_component": "GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0042101 T cell receptor complex;GO:0045121 membrane raft;GO:0001772 immunological synapse", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0050852 T cell receptor signaling pathway;GO:0002250 adaptive immune response;GO:0045059 positive thymic T cell selection;GO:0045582 positive regulation of T cell differentiation", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BMP9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MBU9-1", "uniprot_id": [ { "id": "F1MBU9_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MBU9", "type": "external" } ], "mass": 184097.0, "length": 1634, "protein_name": "Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta", "gene_name": "PIK3C2B", "organism": "Bovine", "refseq_name": "phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X2", "refseq_ac": [ { "id": "XP_059731620", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059731620", "type": "external" } ], "gene_names_uniprotkb": "PIK3C2B", "gene_names_refseq": "PIK3C2B", "protein_names_uniprotkb": "Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta", "protein_names_refseq": "phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta isoform X2", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-1660499)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0035091 phosphatidylinositol binding;GO:0016303 1-phosphatidylinositol-3-kinase activity;GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005829 cytosol;GO:0030139 endocytic vesicle", "go_biological_process": "GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process;GO:0016477 cell migration;GO:0048015 phosphatidylinositol-mediated signaling;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MBU9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKV9-1", "uniprot_id": [ { "id": "E1BKV9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKV9", "type": "external" } ], "mass": 104377.0, "length": 916, "protein_name": "DNA repair endonuclease XPF", "gene_name": "ERCC4", "organism": "Bovine", "refseq_name": "DNA repair endonuclease XPF", "refseq_ac": [ { "id": "NP_001192289", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192289", "type": "external" } ], "gene_names_uniprotkb": "ERCC4", "gene_names_refseq": "ERCC4", "protein_names_uniprotkb": "DNA repair endonuclease XPF; DNA excision repair protein ERCC-4", "protein_names_refseq": "DNA repair endonuclease XPF; excision repair cross-complementing rodent repair deficiency, complementation group 4", "tax_id": 9913, "disease": "", "pathway": " (bta:516371); (R-BTA-5685938); (R-BTA-5696395); (R-BTA-5696400); (R-BTA-6782135); (R-BTA-6783310)", "pathway_count": 6, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic component of a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair, and which is essential for nucleotide excision repair (NER) and interstrand cross-link (ICL) repair., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004520 DNA endonuclease activity;GO:0003697 single-stranded DNA binding;GO:0042802 identical protein binding;GO:0003684 damaged DNA binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005694 chromosome;GO:0000110 nucleotide-excision repair factor 1 complex;GO:0070522 ERCC4-ERCC1 complex;GO:0016604 nuclear body", "go_biological_process": "GO:0006281 DNA repair;GO:0009411 response to UV;GO:0000712 resolution of meiotic recombination intermediates;GO:0061819 telomeric DNA-containing double minutes formation;GO:1905765 negative regulation of protection from non-homologous end joining at telomere", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BKV9-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BM98-1", "uniprot_id": [ { "id": "E1BM98_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BM98", "type": "external" } ], "mass": 73938.0, "length": 663, "protein_name": "Solute carrier family 24 member 2", "gene_name": "SLC24A2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC24A2", "gene_names_refseq": "", "protein_names_uniprotkb": "Solute carrier family 24 member 2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-425561)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015293 symporter activity;GO:0015297 antiporter activity;GO:0005262 calcium channel activity;GO:0008273 calcium, potassium:sodium antiporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0005886 plasma membrane;GO:0098794 postsynapse;GO:0098793 presynapse", "go_biological_process": "GO:0070588 calcium ion transmembrane transport;GO:0006874 intracellular calcium ion homeostasis;GO:0060292 long-term synaptic depression;GO:0071486 cellular response to high light intensity;GO:0060291 long-term synaptic potentiation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BM98-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MBI8-1", "uniprot_id": [ { "id": "F1MBI8_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MBI8", "type": "external" } ], "mass": 148609.0, "length": 1346, "protein_name": "Synaptic Ras GTPase activating protein 1", "gene_name": "SYNGAP1", "organism": "Bovine", "refseq_name": "ras/Rap GTPase-activating protein SynGAP", "refseq_ac": [ { "id": "NP_001192395", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192395", "type": "external" } ], "gene_names_uniprotkb": "SYNGAP1", "gene_names_refseq": "SYNGAP1", "protein_names_uniprotkb": "Synaptic Ras GTPase activating protein 1", "protein_names_refseq": "ras/Rap GTPase-activating protein SynGAP; synaptic Ras GTPase activating protein 1 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:790307)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005096 GTPase activator activity", "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0014069 postsynaptic density;GO:0016020 membrane;GO:0043198 dendritic shaft", "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0050804 modulation of chemical synaptic transmission;GO:1902531 regulation of intracellular signal transduction;GO:0098880 maintenance of postsynaptic specialization structure", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MBI8-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BEI6-1", "uniprot_id": [ { "id": "E1BEI6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BEI6", "type": "external" } ], "mass": 350131.0, "length": 3054, "protein_name": "Serine-protein kinase ATM", "gene_name": "ATM", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "ATM", "gene_names_refseq": "", "protein_names_uniprotkb": "Serine-protein kinase ATM; 2.7.11.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-2559586); (R-BTA-349425); (R-BTA-5685938); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5693548); (R-BTA-5693565); (R-BTA-5693568); (R-BTA-5693571); (R-BTA-5693579); (R-BTA-5693607); (R-BTA-5693616); (R-BTA-6803204); (R-BTA-6803207); (R-BTA-6804756); (R-BTA-6804757); (R-BTA-6804760); (R-BTA-69473); (R-BTA-69541); (R-BTA-9664873)", "pathway_count": 20, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates DYRK2, CHEK2, p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9, UBQLN4 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation. Phosphorylation of DYRK2 in nucleus in response to genotoxic stress prevents its MDM2-mediated ubiquitination and subsequent proteasome degradation. Phosphorylates ATF2 which stimulates its function in DNA damage response. Phosphorylates ERCC6 which is essential for its chromatin remodeling activity at DNA double-strand breaks., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "3.1.3.48", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "3.4.19.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-", "type": "external" }, { "id": "2.3.2.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26", "type": "external" }, { "id": "1.14.11.66", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.66", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "1.14.11.69", "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" }, { "id": "3.6.4.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "2.1.1.357", "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357", "type": "external" }, { "id": "3.4.19.12", "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.3.2.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004677 DNA-dependent protein kinase activity", "go_cellular_component": "GO:0098850 extrinsic component of synaptic vesicle membrane;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005782 peroxisomal matrix;GO:0005813 centrosome", "go_biological_process": "GO:0010506 regulation of autophagy;GO:0010628 positive regulation of gene expression;GO:0030335 positive regulation of cell migration;GO:0043065 positive regulation of apoptotic process;GO:0045785 positive regulation of cell adhesion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BEI6-1", "record_type": "protein", "filter_code": "0000000.0000001.001000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BL72-1", "uniprot_id": [ { "id": "E1BL72_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BL72", "type": "external" } ], "mass": 98777.0, "length": 887, "protein_name": "Dolichyl-phosphate-mannose--protein mannosyltransferase", "gene_name": "POMT2", "organism": "Bovine", "refseq_name": "protein O-mannosyl-transferase 2 isoform X1", "refseq_ac": [ { "id": "XP_005212256", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005212256", "type": "external" } ], "gene_names_uniprotkb": "POMT2", "gene_names_refseq": "POMT2", "protein_names_uniprotkb": "Dolichyl-phosphate-mannose--protein mannosyltransferase; 2.4.1.109", "protein_names_refseq": "protein O-mannosyl-transferase 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-8932504); (R-BTA-8932505); (R-BTA-8932506); (R-BTA-9768727)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.109", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.109", "type": "external" } ], "go_molecular_function": "GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum", "go_biological_process": "GO:0035269 protein O-linked glycosylation via mannose", "synthesized_glycan_count": 1677, "hit_score": 0.1, "record_id": "E1BL72-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BE83-1", "uniprot_id": [ { "id": "E1BE83_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BE83", "type": "external" } ], "mass": 163507.0, "length": 1446, "protein_name": "FA complementation group D2", "gene_name": "FANCD2", "organism": "Bovine", "refseq_name": "Fanconi anemia group D2 protein isoform X1", "refseq_ac": [ { "id": "XP_024838445", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838445", "type": "external" } ], "gene_names_uniprotkb": "FANCD2", "gene_names_refseq": "FANCD2", "protein_names_uniprotkb": "FA complementation group D2", "protein_names_refseq": "Fanconi anemia group D2 protein isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-6783310)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0070182 DNA polymerase binding", "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0016604 nuclear body;GO:0000793 condensed chromosome;GO:0005856 cytoskeleton", "go_biological_process": "GO:0006281 DNA repair;GO:0010332 response to gamma radiation;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0036297 interstrand cross-link repair;GO:0007129 homologous chromosome pairing at meiosis", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BE83-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BK33-1", "uniprot_id": [ { "id": "E1BK33_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BK33", "type": "external" } ], "mass": 170971.0, "length": 1572, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "MAST1", "organism": "Bovine", "refseq_name": "microtubule-associated serine/threonine-protein kinase 1", "refseq_ac": [ { "id": "NP_001178457", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178457", "type": "external" } ], "gene_names_uniprotkb": "MAST1", "gene_names_refseq": "MAST1", "protein_names_uniprotkb": "non-specific serine/threonine protein kinase; 2.7.11.1", "protein_names_refseq": "microtubule-associated serine/threonine-protein kinase 1", "tax_id": 9913, "disease": "", "pathway": " (bta:539825)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 3, "predicted_n_glycosites": 0, "predicted_o_glycosites": 3, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 3, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0008017 microtubule binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0043025 neuronal cell body;GO:0015630 microtubule cytoskeleton;GO:0043005 neuron projection", "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0007010 cytoskeleton organization;GO:0007420 brain development", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BK33-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BH60-1", "uniprot_id": [ { "id": "E1BH60_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BH60", "type": "external" } ], "mass": 124601.0, "length": 1118, "protein_name": "Phosphoinositide phospholipase C", "gene_name": "PLCL2", "organism": "Bovine", "refseq_name": "inactive phospholipase C-like protein 2", "refseq_ac": [ { "id": "NP_001179184", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179184", "type": "external" } ], "gene_names_uniprotkb": "PLCL2", "gene_names_refseq": "PLCL2", "protein_names_uniprotkb": "Phosphoinositide phospholipase C; 3.1.4.11", "protein_names_refseq": "inactive phospholipase C-like protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:510408)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.1.4.11", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11", "type": "external" } ], "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0004435 phosphatidylinositol-4,5-bisphosphate 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"NP_001179452", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179452", "type": "external" } ], "gene_names_uniprotkb": "KCNMB4", "gene_names_refseq": "KCNMB4", "protein_names_uniprotkb": "Calcium-activated potassium channel subunit beta; BK channel subunit beta; BKbeta; Calcium-activated potassium channel, subfamily M subunit beta; Charybdotoxin receptor subunit beta; K(VCA)beta; Maxi K channel subunit beta; Slo-beta", "protein_names_refseq": "calcium-activated potassium channel subunit beta-4; potassium large conductance calcium-activated channel, subfamily M, beta member 4", "tax_id": 9913, "disease": "", "pathway": " (bta:520448); (R-BTA-1296052)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015459 potassium channel regulator activity;GO:0015269 calcium-activated potassium channel activity", "go_cellular_component": "GO:0008076 voltage-gated potassium channel complex", "go_biological_process": "GO:0005513 detection of calcium ion;GO:0019228 neuronal action potential", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCE5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKP7-1", "uniprot_id": [ { "id": "E1BKP7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKP7", "type": "external" } ], "mass": 96937.0, "length": 869, "protein_name": "receptor protein-tyrosine kinase", "gene_name": "MUSK", "organism": "Bovine", "refseq_name": "muscle, skeletal receptor tyrosine-protein kinase isoform X1", "refseq_ac": [ { "id": "XP_059745177", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059745177", "type": "external" } ], "gene_names_uniprotkb": "MUSK", "gene_names_refseq": "MUSK", "protein_names_uniprotkb": "receptor protein-tyrosine kinase; 2.7.10.1", "protein_names_refseq": "muscle, skeletal receptor tyrosine-protein kinase isoform X1", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0017147 Wnt-protein binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0045211 postsynaptic membrane", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007528 neuromuscular junction development;GO:0030154 cell differentiation;GO:0010604 positive regulation of macromolecule metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BKP7-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BDX8-1", "uniprot_id": [ { "id": "E1BDX8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BDX8", "type": "external" } ], "mass": 534723.0, "length": 4671, "protein_name": "Cytoplasmic dynein 1 heavy chain 1", "gene_name": "DYNC1H1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DYNC1H1", "gene_names_refseq": "", "protein_names_uniprotkb": "Cytoplasmic dynein 1 heavy chain 1; Cytoplasmic dynein heavy chain 1; Dynein heavy chain, cytosolic", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-141430); (R-BTA-141444); (R-BTA-2132295); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-2565942); (R-BTA-3371497); (R-BTA-380259); (R-BTA-380270); (R-BTA-380284); (R-BTA-380320); (R-BTA-5620912); (R-BTA-5663220); (R-BTA-6798695); (R-BTA-6807878); (R-BTA-6811436); (R-BTA-8854518); (R-BTA-9646399); (R-BTA-9648025)", "pathway_count": 19, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Plays a role in mitotic spindle assembly and metaphase plate congression., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0008569 minus-end-directed microtubule motor activity;GO:0051959 dynein light intermediate chain binding;GO:0045505 dynein intermediate chain binding;GO:0042802 identical protein binding", "go_cellular_component": "GO:0005874 microtubule;GO:0030286 dynein complex;GO:0005813 centrosome;GO:0005938 cell cortex;GO:0030175 filopodium", "go_biological_process": "GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0051293 establishment of spindle localization;GO:0090235 regulation of metaphase plate congression;GO:1905832 positive regulation of spindle assembly", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BDX8-1", "record_type": "protein", "filter_code": "0000000.0000001.000100.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BD54-1", "uniprot_id": [ { "id": "E1BD54_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BD54", "type": "external" } ], "mass": 71953.0, "length": 655, "protein_name": "Anion exchange transporter", "gene_name": "SLC26A7", "organism": "Bovine", "refseq_name": "anion exchange transporter", "refseq_ac": [ { "id": "NP_001180075", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180075", "type": "external" } ], "gene_names_uniprotkb": "SLC26A7", "gene_names_refseq": "SLC26A7", "protein_names_uniprotkb": "Anion exchange transporter; Solute carrier family 26 member 7", "protein_names_refseq": "anion exchange transporter", "tax_id": 9913, "disease": "", "pathway": " (bta:617196); (R-BTA-427601)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "5.6.1.6", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6", "type": "external" }, { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" }, { "id": "1.8.5.1", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1", "type": "external" } ], "go_molecular_function": "GO:0005254 chloride channel activity;GO:0140900 chloride:bicarbonate antiporter activity;GO:0019531 oxalate transmembrane transporter activity;GO:0015116 sulfate transmembrane transporter activity", "go_cellular_component": "GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0055038 recycling endosome membrane;GO:0016328 lateral plasma membrane", "go_biological_process": "GO:0055085 transmembrane transport;GO:0019532 oxalate transport;GO:0015705 iodide transport;GO:1902358 sulfate transmembrane transport;GO:1905039 carboxylic acid transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BD54-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MEA6-1", "uniprot_id": [ { "id": "F1MEA6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MEA6", "type": "external" } ], "mass": 120649.0, "length": 1054, "protein_name": "DIS3-like exonuclease 1", "gene_name": "DIS3L", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "DIS3L", "gene_names_refseq": "", "protein_names_uniprotkb": "DIS3-like exonuclease 1; 3.1.13.1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. 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activity;GO:0042393 histone binding", "go_cellular_component": "GO:0016604 nuclear body;GO:0000776 kinetochore;GO:0035861 site of double-strand break;GO:0005634 nucleus;GO:0005737 cytoplasm", "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0006303 double-strand break repair via nonhomologous end joining;GO:0045830 positive regulation of isotype switching", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BDS6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BGA6-1", "uniprot_id": [ { "id": "E1BGA6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BGA6", "type": "external" } ], "mass": 94335.0, "length": 831, "protein_name": "Conserved oligomeric Golgi complex subunit 3", "gene_name": "COG3", 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"filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BLD1-1", "uniprot_id": [ { "id": "E1BLD1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BLD1", "type": "external" } ], "mass": 289338.0, "length": 2610, "protein_name": "E3 ubiquitin-protein ligase", "gene_name": "HECTD1", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase HECTD1 isoform X1", "refseq_ac": [ { "id": "XP_002696742", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002696742", "type": "external" } ], "gene_names_uniprotkb": "HECTD1", "gene_names_refseq": "HECTD1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase; 2.3.2.26", "protein_names_refseq": "E3 ubiquitin-protein ligase HECTD1 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:536240)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from 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"E1BLL5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BLL5", "type": "external" } ], "mass": 35981.0, "length": 320, "protein_name": "Kynurenine formamidase", "gene_name": "AFMID", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "AFMID", "gene_names_refseq": "", "protein_names_uniprotkb": "Kynurenine formamidase; 3.5.1.9; Arylformamidase; FKF; KFA; KFase; N-formylkynurenine formamidase", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites., [UniProtKB, HAMAP, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "3.5.1.9", "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.9", "type": "external" } ], "go_molecular_function": "GO:0004061 arylformamidase activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005737 cytoplasm", "go_biological_process": "GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BLL5-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNS9-1", "uniprot_id": [ { "id": "E1BNS9_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNS9", "type": "external" } ], "mass": 36015.0, "length": 332, "protein_name": "L-lactate dehydrogenase", "gene_name": "LDHC", "organism": "Bovine", "refseq_name": "L-lactate dehydrogenase C chain isoform 1", "refseq_ac": [ { "id": "NP_001106720", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106720", "type": "external" } ], "gene_names_uniprotkb": "LDHC", "gene_names_refseq": "LDHC", "protein_names_uniprotkb": "L-lactate dehydrogenase; 1.1.1.27", "protein_names_refseq": "L-lactate dehydrogenase C chain isoform 1; L-lactate dehydrogenase C", "tax_id": 9913, "disease": "", "pathway": " (bta:537256); (R-BTA-70268)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "28238530", "class_list": "", "function": "Hyaluronic acid induces sperm capacitation involving lactate dehydrogenase (LDH) and creatine kinase (CK) activities, thereby reducing oxidative metabolism, and this process is mediated by mAC., [RefSeq, PubMed]; Possible role in sperm motility., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.1.1.27", "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27", "type": "external" } ], "go_molecular_function": "GO:0004459 L-lactate dehydrogenase (NAD+) activity;GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0031514 motile cilium", "go_biological_process": "GO:0019752 carboxylic acid metabolic process;GO:0006089 lactate metabolic process;GO:0042867 pyruvate catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BNS9-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BKZ1-1", "uniprot_id": [ { "id": "E1BKZ1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BKZ1", "type": "external" } ], "mass": 56362.0, "length": 519, "protein_name": "Glutathione reductase", "gene_name": "GSR", "organism": "Bovine", "refseq_name": "glutathione reductase, mitochondrial", "refseq_ac": [ { "id": "NP_001107662", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107662", "type": "external" } ], "gene_names_uniprotkb": "GSR", "gene_names_refseq": "GSR", "protein_names_uniprotkb": "Glutathione reductase; 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Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Liver biopsy is a valuable tool for detecting oxidative stress and for diagnosing hepatic dysfunction in cattle from glutathione and glutathione reductase levels., [RefSeq, PubMed]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.1.7", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.1.7", "type": "external" } ], "go_molecular_function": "GO:0050660 flavin adenine dinucleotide binding;GO:0004362 glutathione-disulfide reductase (NADPH) activity;GO:0050661 NADP binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0009897 external side of plasma membrane", "go_biological_process": "GO:0045454 cell redox homeostasis;GO:0034599 cellular response to oxidative stress;GO:0006749 glutathione metabolic process", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BKZ1-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BGY4-1", "uniprot_id": [ { "id": "E1BGY4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BGY4", "type": "external" } ], "mass": 20766.0, "length": 184, "protein_name": "Tumor necrosis factor ligand superfamily member 4", "gene_name": "TNFSF4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "TNFSF4", "gene_names_refseq": "", "protein_names_uniprotkb": "Tumor necrosis factor ligand superfamily member 4; OX40 ligand", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5669034)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Cytokine that binds to TNFRSF4. 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}, { "id": "2.7.10.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.10.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0017147 Wnt-protein binding;GO:0031435 mitogen-activated protein kinase kinase kinase binding", "go_cellular_component": "GO:0016020 membrane;GO:0045202 synapse;GO:0005886 plasma membrane;GO:0030424 axon;GO:0043235 receptor complex", "go_biological_process": "GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0016055 Wnt signaling pathway;GO:0030335 positive regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BC57-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BL71-1", "uniprot_id": [ { "id": "E1BL71_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BL71", "type": "external" } ], "mass": 83385.0, "length": 731, "protein_name": "S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1", "gene_name": "TYW1", "organism": "Bovine", "refseq_name": "tRNA wybutosine-synthesizing protein 1 homolog", "refseq_ac": [ { "id": "NP_001179682", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179682", "type": "external" } ], "gene_names_uniprotkb": "TYW1", "gene_names_refseq": "TYW1", "protein_names_uniprotkb": "S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1; 4.1.3.44; Radical S-adenosyl methionine and flavodoxin domain-containing protein 1; tRNA wybutosine-synthesizing protein 1 homolog; tRNA-yW-synthesizing protein", 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Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.1.3.44", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.3.44", "type": "external" } ], "go_molecular_function": "GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0010181 FMN binding;GO:0102521 tRNA-4-demethylwyosine synthase activity", "go_cellular_component": "", "go_biological_process": "GO:0008033 tRNA processing;GO:0031591 wybutosine biosynthetic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BL71-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJ09-1", "uniprot_id": [ { "id": "E1BJ09_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJ09", "type": "external" } ], "mass": 110066.0, "length": 1006, "protein_name": "E3 ubiquitin-protein ligase MIB1", "gene_name": "MIB1", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase MIB1", "refseq_ac": [ { "id": "NP_001192959", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192959", "type": "external" } ], "gene_names_uniprotkb": "MIB1", "gene_names_refseq": "MIB1", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MIB1; 2.3.2.27; DAPK-interacting protein 1; E3 ubiquitin-protein ligase mib1; Mind bomb homolog 1; RING-type E3 ubiquitin transferase MIB1", "protein_names_refseq": "E3 ubiquitin-protein ligase MIB1; mindbomb E3 ubiquitin protein ligase 1; mindbomb homolog 1", "tax_id": 9913, "disease": "", "pathway": " (bta:533735)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, 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cell division", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BC46-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MC36-1", "uniprot_id": [ { "id": "F1MC36_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MC36", "type": "external" } ], "mass": 107071.0, "length": 962, "protein_name": "Sodium/calcium exchanger 1", "gene_name": "SLC8A1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SLC8A1", "gene_names_refseq": "", "protein_names_uniprotkb": "Sodium/calcium exchanger 1; Na(+)/Ca(2+)-exchange protein 1; Solute carrier family 8 member 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-418359); (R-BTA-425561); (R-BTA-5578775)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0005432 calcium:sodium antiporter activity;GO:0030506 ankyrin binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0045202 synapse;GO:0030424 axon;GO:0098794 postsynapse;GO:0042383 sarcolemma", "go_biological_process": "GO:0007154 cell communication;GO:0006874 intracellular calcium ion homeostasis;GO:0006883 intracellular sodium ion homeostasis;GO:0030501 positive regulation of bone mineralization;GO:0035994 response to muscle stretch", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MC36-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BDK7-1", "uniprot_id": [ { "id": "E1BDK7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BDK7", "type": "external" } ], "mass": 86003.0, "length": 777, "protein_name": "Zinc phosphodiesterase ELAC protein 2", "gene_name": "ELAC2", "organism": "Bovine", "refseq_name": "zinc phosphodiesterase ELAC protein 2", "refseq_ac": [ { "id": "NP_001179994", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179994", "type": "external" } ], "gene_names_uniprotkb": "ELAC2", "gene_names_refseq": "ELAC2", "protein_names_uniprotkb": "Zinc phosphodiesterase ELAC protein 2; 3.1.26.11; ElaC homolog protein 2; Ribonuclease Z 2; tRNA 3 endonuclease 2; tRNase Z 2", "protein_names_refseq": "elaC homolog 2; zinc phosphodiesterase ELAC protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:509256)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0046872 metal ion binding;GO:0042781 3'-tRNA processing endoribonuclease activity", "go_cellular_component": "GO:0005634 nucleus;GO:0042645 mitochondrial nucleoid;GO:0005654 nucleoplasm;GO:0005739 mitochondrion", "go_biological_process": "GO:1990180 mitochondrial tRNA 3'-end processing", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BDK7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BLR4-1", "uniprot_id": [ { "id": "E1BLR4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BLR4", "type": "external" } ], "mass": 93870.0, "length": 830, "protein_name": "Inactive rhomboid protein", "gene_name": "RHBDF2", "organism": "Bovine", "refseq_name": "inactive rhomboid protein 2", "refseq_ac": [ { "id": "XP_005221360", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005221360", "type": "external" } ], "gene_names_uniprotkb": "RHBDF2", "gene_names_refseq": "RHBDF2", "protein_names_uniprotkb": "Inactive rhomboid protein; Rhomboid family member; Rhomboid veinlet-like protein; iRhom", "protein_names_refseq": "inactive rhomboid protein 2", "tax_id": 9913, "disease": "", "pathway": " (bta:517903)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004252 serine-type endopeptidase activity", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005886 plasma membrane", "go_biological_process": "GO:0050709 negative regulation of protein secretion;GO:0042058 regulation of epidermal growth factor receptor signaling pathway;GO:0050708 regulation of protein secretion", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BLR4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BF82-1", "uniprot_id": [ { "id": "E1BF82_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BF82", "type": "external" } ], "mass": 73767.0, "length": 642, "protein_name": "Kinetochore protein NDC80", "gene_name": "NDC80", "organism": "Bovine", "refseq_name": "kinetochore protein NDC80 homolog", "refseq_ac": [ { "id": "NP_001193512", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193512", "type": "external" } ], "gene_names_uniprotkb": "NDC80", "gene_names_refseq": "NDC80", "protein_names_uniprotkb": "Kinetochore protein NDC80", "protein_names_refseq": "NDC80 homolog, kinetochore complex component; kinetochore protein NDC80 homolog", "tax_id": 9913, "disease": "", "pathway": " (bta:538789); (R-BTA-141430); (R-BTA-141444); (R-BTA-2467813); (R-BTA-2500257); (R-BTA-5663220); (R-BTA-9648025)", "pathway_count": 7, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008017 microtubule binding;GO:0042802 identical protein binding;GO:0140483 kinetochore adaptor activity", "go_cellular_component": "GO:0031262 Ndc80 complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0016607 nuclear speck", "go_biological_process": "GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007051 spindle organization;GO:0000132 establishment of mitotic spindle orientation;GO:0007052 mitotic spindle organization", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BF82-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MDS3-1", "uniprot_id": [ { "id": "F1MDS3_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MDS3", "type": "external" } ], "mass": 70650.0, "length": 640, "protein_name": "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial", "gene_name": "PCK2", "organism": "Bovine", "refseq_name": "phosphoenolpyruvate carboxykinase [GTP], mitochondrial", "refseq_ac": [ { "id": "NP_001192523", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001192523", "type": "external" } ], "gene_names_uniprotkb": "PCK2", "gene_names_refseq": "PCK2", "protein_names_uniprotkb": "Phosphoenolpyruvate carboxykinase [GTP], mitochondrial; 4.1.1.32; Phosphoenolpyruvate carboxykinase, cytosolic [GTP]; Serine-protein kinase PCK1; Serine/threonine-protein kinase PCK2", "protein_names_refseq": "phosphoenolpyruvate carboxykinase [GTP], mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:282856); (R-BTA-70263)", "pathway_count": 2, "publication_count": 1, "publication_id_list": "12388798", "class_list": "", "function": "Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. Can play an active role in glyceroneogenesis and gluconeogenesis. Also acts as a serine/threonine-protein kinase: phosphorylates and activates ACSL4, thereby promoting ferroptosis., [UniProtKB, UniProtKB, UniProtKB]; Transition to lactation does not alter expression of the mitochondrial form of PEPCK. Publication Status: Online-Only, [RefSeq, PubMed]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "2.7.11.25", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0016301 kinase activity;GO:0004613 phosphoenolpyruvate carboxykinase (GTP) activity;GO:0004674 protein serine/threonine kinase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix", "go_biological_process": "GO:0006094 gluconeogenesis;GO:0046327 glycerol biosynthetic process from pyruvate;GO:0032869 cellular response to insulin stimulus;GO:0042594 response to starvation;GO:0071333 cellular response to glucose stimulus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "F1MDS3-1", "record_type": "protein", "filter_code": "0000000.0000101.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BPA4-1", "uniprot_id": [ { "id": "E1BPA4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BPA4", "type": "external" } ], "mass": 57487.0, "length": 530, "protein_name": "Carbonic anhydrase", "gene_name": "CA9", "organism": "Bovine", "refseq_name": "carbonic anhydrase 9 isoform X2", "refseq_ac": [ { "id": "XP_002689744", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002689744", "type": "external" } ], "gene_names_uniprotkb": "CA9", "gene_names_refseq": "CA9", "protein_names_uniprotkb": "Carbonic anhydrase; 4.2.1.1", "protein_names_refseq": "carbonic anhydrase 9 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:511923); (R-BTA-1475029)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Reversible hydration of carbon dioxide., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "4.2.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.1", "type": "external" }, { "id": "4.2.1.69", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.69", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004089 carbonate dehydratase activity;GO:0140677 molecular function activator activity", "go_cellular_component": "GO:0005886 plasma membrane", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BPA4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BFR4-1", "uniprot_id": [ { "id": "E1BFR4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BFR4", "type": "external" } ], "mass": 214480.0, "length": 1929, "protein_name": "Plexin-A1", "gene_name": "PLXNA1", "organism": "Bovine", "refseq_name": "plexin-A1 isoform X2", "refseq_ac": [ { "id": "XP_024838888", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024838888", "type": "external" } ], "gene_names_uniprotkb": "PLXNA1", "gene_names_refseq": "PLXNA1", "protein_names_uniprotkb": "Plexin-A1", "protein_names_refseq": "plexin-A1 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:531240); (R-BTA-399954); (R-BTA-399955); (R-BTA-399956); (R-BTA-9696273)", "pathway_count": 5, "publication_count": 1, "publication_id_list": "30573663", "class_list": "", "function": "Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Acts as coreceptor of TREM2 for SEMA6D in dendritic cells and is involved in the generation of immune responses and skeletal homeostasis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0017154 semaphorin receptor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0098978 glutamatergic synapse;GO:0002116 semaphorin receptor complex", "go_biological_process": "GO:0097485 neuron projection guidance;GO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell;GO:0071526 semaphorin-plexin signaling pathway;GO:0007416 synapse assembly;GO:0030334 regulation of cell migration", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BFR4-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BMA5-1", "uniprot_id": [ { "id": "E1BMA5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BMA5", "type": "external" } ], "mass": 36041.0, "length": 322, "protein_name": "uridine/cytidine kinase", "gene_name": "UCK2", "organism": "Bovine", "refseq_name": "uridine-cytidine kinase 2 isoform X1", "refseq_ac": [ { "id": "XP_059740815", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_059740815", "type": "external" } ], "gene_names_uniprotkb": "UCK2", "gene_names_refseq": "UCK2", "protein_names_uniprotkb": "uridine/cytidine kinase; 2.7.1.48", "protein_names_refseq": "uridine-cytidine kinase 2 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-73614)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.48", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0004849 uridine kinase activity;GO:0042802 identical protein binding;GO:0043771 cytidine kinase activity", "go_cellular_component": "GO:0005737 cytoplasm", "go_biological_process": "GO:0044206 UMP salvage;GO:0044211 CTP salvage", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BMA5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BM97-1", "uniprot_id": [ { "id": "E1BM97_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BM97", "type": "external" } ], "mass": 97724.0, "length": 877, "protein_name": "Hyperpolarization activated cyclic nucleotide gated potassium channel 1", "gene_name": "HCN1", "organism": "Bovine", "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1", "refseq_ac": [ { "id": "NP_001193509", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193509", "type": "external" } ], "gene_names_uniprotkb": "HCN1", "gene_names_refseq": "HCN1", "protein_names_uniprotkb": "Hyperpolarization activated cyclic nucleotide gated potassium channel 1", "protein_names_refseq": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1", "tax_id": 9913, "disease": "", "pathway": " (bta:538255); (R-BTA-1296061)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.8.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-", "type": "external" } ], "go_molecular_function": "GO:0005272 sodium channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0030552 cAMP binding;GO:0042802 identical protein binding;GO:0005248 voltage-gated sodium channel activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0034702 monoatomic ion channel complex;GO:0098978 glutamatergic synapse;GO:0048787 presynaptic active zone membrane;GO:0030424 axon", "go_biological_process": "GO:0051289 protein homotetramerization;GO:0071320 cellular response to cAMP;GO:0035725 sodium ion transmembrane transport;GO:0003254 regulation of membrane depolarization;GO:0071805 potassium ion transmembrane transport", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BM97-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BFK4-1", "uniprot_id": [ { "id": "E1BFK4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BFK4", "type": "external" } ], "mass": 176285.0, "length": 1570, "protein_name": "Telomerase-binding protein EST1A", "gene_name": "SMG6", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "SMG6", "gene_names_refseq": "", "protein_names_uniprotkb": "Telomerase-binding protein EST1A; 3.1.-.-", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-975957)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER)., [UniProtKB, UniProtKB, UniProtKB]; Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "3.6.1.62", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62", "type": "external" }, { "id": "3.1.3.16", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16", "type": "external" }, { "id": "3.6.4.13", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13", "type": "external" }, { "id": "4.2.99.18", "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18", "type": "external" } ], "go_molecular_function": "GO:0016787 hydrolase activity;GO:0030145 manganese ion binding;GO:0043021 ribonucleoprotein complex binding;GO:0042162 telomeric DNA binding;GO:0070182 DNA polymerase binding", "go_cellular_component": "GO:0005730 nucleolus;GO:0005829 cytosol;GO:0000781 chromosome, telomeric region;GO:0035145 exon-exon junction complex;GO:0005697 telomerase holoenzyme complex", "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:1904354 negative regulation of telomere capping", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BFK4-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BP88-1", "uniprot_id": [ { "id": "E1BP88_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BP88", "type": "external" } ], "mass": 60069.0, "length": 548, "protein_name": "Cyclic AMP-responsive element-binding protein 3-like protein 4", "gene_name": "CREB3L4", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CREB3L4", "gene_names_refseq": "", "protein_names_uniprotkb": "Cyclic AMP-responsive element-binding protein 3-like protein 4", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:529566)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific", "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0005634 nucleus;GO:0005794 Golgi apparatus", "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006986 response to unfolded protein;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BP88-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BJQ1-1", "uniprot_id": [ { "id": "E1BJQ1_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BJQ1", "type": "external" } ], "mass": 112888.0, "length": 1020, "protein_name": "Glycine cleavage system P protein", "gene_name": "GLDC", "organism": "Bovine", "refseq_name": "glycine dehydrogenase (decarboxylating), mitochondrial", "refseq_ac": [ { "id": "NP_001179880", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179880", "type": "external" } ], "gene_names_uniprotkb": "GLDC", "gene_names_refseq": "GLDC", "protein_names_uniprotkb": "Glycine cleavage system P protein; 1.4.4.2", "protein_names_refseq": "glycine dehydrogenase (decarboxylating), mitochondrial", "tax_id": 9913, "disease": "", "pathway": " (bta:507688); (R-BTA-6783984)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "1.4.4.2", "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.4.2", "type": "external" } ], "go_molecular_function": "GO:0004375 glycine dehydrogenase (decarboxylating) activity;GO:0030170 pyridoxal phosphate binding;GO:0016829 lyase activity;GO:0016594 glycine binding", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005960 glycine cleavage complex", "go_biological_process": "GO:0006546 glycine catabolic process;GO:0019464 glycine decarboxylation via glycine cleavage system", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BJQ1-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BBY7-1", "uniprot_id": [ { "id": "E1BBY7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BBY7", "type": "external" } ], "mass": 94509.0, "length": 840, "protein_name": "Heat shock 70 kDa protein 4", "gene_name": "HSPA4", "organism": "Bovine", "refseq_name": "heat shock 70 kDa protein 4", "refseq_ac": [ { "id": "NP_001107664", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107664", "type": "external" } ], "gene_names_uniprotkb": "HSPA4", "gene_names_refseq": "HSPA4", "protein_names_uniprotkb": "Heat shock 70 kDa protein 4", "protein_names_refseq": "heat shock 70 kDa protein 4; heat shock 70kDa protein 4", "tax_id": 9913, "disease": "", "pathway": " (bta:536558); (R-BTA-3371453)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000774 adenyl-nucleotide exchange factor activity", "go_cellular_component": "GO:0005737 cytoplasm;GO:0005634 nucleus;GO:0005829 cytosol;GO:0070062 extracellular exosome", "go_biological_process": "GO:0006457 protein folding;GO:0051131 chaperone-mediated protein complex assembly;GO:0030150 protein import into mitochondrial matrix", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BBY7-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BL90-1", "uniprot_id": [ { "id": "E1BL90_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BL90", "type": "external" } ], "mass": 132412.0, "length": 1195, "protein_name": "Partner and localizer of BRCA2", "gene_name": "PALB2", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "PALB2", "gene_names_refseq": "", "protein_names_uniprotkb": "Partner and localizer of BRCA2", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5693568); (R-BTA-5693579)", "pathway_count": 4, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003677 DNA binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0032991 protein-containing complex", "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BL90-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "F1MAV6-1", "uniprot_id": [ { "id": "F1MAV6_BOVIN", "url": "https://www.uniprot.org/uniprot/F1MAV6", "type": "external" } ], "mass": 86872.0, "length": 790, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "RFWD3", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase RFWD3 isoform X1", "refseq_ac": [ { "id": "XP_002694769", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002694769", "type": "external" } ], "gene_names_uniprotkb": "RFWD3", "gene_names_refseq": "RFWD3", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "E3 ubiquitin-protein ligase RFWD3 isoform X1", "tax_id": 9913, "disease": "", "pathway": " (bta:540072)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0002039 p53 binding;GO:0097371 MDM2/MDM4 family protein binding", "go_cellular_component": "GO:0005737 cytoplasm;GO:0016605 PML body;GO:0005829 cytosol;GO:0035861 site of double-strand break", "go_biological_process": "GO:0016567 protein ubiquitination;GO:0036297 interstrand cross-link repair;GO:2000001 regulation of DNA damage checkpoint;GO:0010212 response to ionizing radiation;GO:0000724 double-strand break repair via homologous recombination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "F1MAV6-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BLB2-1", "uniprot_id": [ { "id": "E1BLB2_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BLB2", "type": "external" } ], "mass": 36137.0, "length": 316, "protein_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2", "gene_name": "TNFAIP1", "organism": "Bovine", "refseq_name": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2", "refseq_ac": [ { "id": "NP_001179219", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179219", "type": "external" } ], "gene_names_uniprotkb": "TNFAIP1", "gene_names_refseq": "TNFAIP1", "protein_names_uniprotkb": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1", "protein_names_refseq": "BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; tumor necrosis factor, alpha-induced protein 1 (endothelial)", "tax_id": 9913, "disease": "", "pathway": " (bta:539674); (R-BTA-9696264); (R-BTA-9696270)", "pathway_count": 3, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0031463 Cul3-RING ubiquitin ligase complex", "go_biological_process": "GO:0051260 protein homooligomerization;GO:0006955 immune response;GO:0016477 cell migration;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BLB2-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNE7-1", "uniprot_id": [ { "id": "E1BNE7_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNE7", "type": "external" } ], "mass": 50184.0, "length": 456, "protein_name": "Caveolae associated protein 1", "gene_name": "CAVIN1", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "CAVIN1", "gene_names_refseq": "", "protein_names_uniprotkb": "Caveolae associated protein 1", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-73863); 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3.1.-.-", "protein_names_refseq": "exonuclease 1", "tax_id": 9913, "disease": "", "pathway": " (bta:506390); (R-BTA-5358565); (R-BTA-5685938); (R-BTA-5685942); (R-BTA-5693537); (R-BTA-5693568); (R-BTA-5693579); (R-BTA-5693607); (R-BTA-5693616); (R-BTA-6804756); (R-BTA-69473)", "pathway_count": 11, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis., [UniProtKB, UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.1.48", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48", "type": "external" }, { "id": "6.5.1.1", "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1", "type": "external" }, { "id": "2.7.7.7", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7", "type": "external" }, { "id": "5.6.2.4", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4", "type": "external" }, { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" }, { "id": "5.6.2.1", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1", "type": "external" }, { "id": "2.7.11.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1", "type": "external" }, { "id": "3.1.-.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-", "type": "external" }, { "id": "5.6.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3", "type": "external" }, { "id": "3.6.4.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-", "type": "external" } ], "go_molecular_function": "GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0004519 endonuclease activity;GO:0035312 5'-3' DNA exonuclease activity;GO:0003682 chromatin binding", "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body", "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0051321 meiotic cell cycle;GO:0002376 immune system process;GO:0006298 mismatch repair", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BF15-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BNT4-1", "uniprot_id": [ { "id": "E1BNT4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BNT4", "type": "external" } ], "mass": 85653.0, "length": 783, "protein_name": "E3 ubiquitin-protein ligase RNF43", "gene_name": "RNF43", "organism": "Bovine", "refseq_name": "E3 ubiquitin-protein ligase RNF43 precursor", "refseq_ac": [ { "id": "NP_001178123", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001178123", "type": "external" } ], "gene_names_uniprotkb": "RNF43", "gene_names_refseq": "RNF43", "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF43; 2.3.2.27; RING finger protein 43; RING-type E3 ubiquitin transferase RNF43", "protein_names_refseq": "E3 ubiquitin-protein ligase RNF43 precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:784035); (R-BTA-4641263)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification., [UniProtKB, UniProtKB]", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.3.2.27", "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27", "type": "external" } ], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0005109 frizzled binding", "go_cellular_component": "GO:0005886 plasma membrane;GO:0005635 nuclear envelope;GO:0005789 endoplasmic reticulum membrane", "go_biological_process": "GO:0016055 Wnt signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0072089 stem cell proliferation", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BNT4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BB11-1", "uniprot_id": [ { "id": "E1BB11_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BB11", "type": "external" } ], "mass": 91056.0, "length": 810, "protein_name": "Sodium/hydrogen exchanger", "gene_name": "SLC9A2", "organism": "Bovine", "refseq_name": "sodium/hydrogen exchanger 2", "refseq_ac": [ { "id": "XP_002691231", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_002691231", "type": "external" } ], "gene_names_uniprotkb": "SLC9A2", "gene_names_refseq": "SLC9A2", "protein_names_uniprotkb": "Sodium/hydrogen exchanger", "protein_names_refseq": "sodium/hydrogen exchanger 2", "tax_id": 9913, "disease": "", "pathway": " (bta:526134); (R-BTA-425986)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0016324 apical plasma membrane", "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0051453 regulation of intracellular pH;GO:0071805 potassium ion transmembrane transport;GO:0098719 sodium ion import across plasma membrane", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BB11-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BB31-1", "uniprot_id": [ { "id": "E1BB31_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BB31", "type": "external" } ], "mass": 39498.0, "length": 360, "protein_name": "RING-type E3 ubiquitin transferase", "gene_name": "BIRC7", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "BIRC7", "gene_names_refseq": "", "protein_names_uniprotkb": "RING-type E3 ubiquitin transferase; 2.3.2.27", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": "", "pathway_count": 0, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process;GO:0004869 cysteine-type endopeptidase inhibitor activity", "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005813 centrosome", "go_biological_process": "GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process;GO:0046330 positive regulation of JNK cascade;GO:0006915 apoptotic process;GO:0016567 protein ubiquitination", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BB31-1", "record_type": "protein", "filter_code": "0000000.0000000.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BB36-1", "uniprot_id": [ { "id": "E1BB36_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BB36", "type": "external" } ], "mass": 51660.0, "length": 446, "protein_name": "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase", "gene_name": "MGAT2", "organism": "Bovine", "refseq_name": "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase", "refseq_ac": [ { "id": "XP_005211790", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_005211790", "type": "external" } ], "gene_names_uniprotkb": "MGAT2", "gene_names_refseq": "MGAT2", "protein_names_uniprotkb": "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; 2.4.1.143; Beta-1,2-N-acetylglucosaminyltransferase II; GlcNAc-T II; Mannoside acetylglucosaminyltransferase 2; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II", "protein_names_refseq": "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase", "tax_id": 9913, "disease": "", "pathway": " (bta:101906103); (R-BTA-975578)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 2, "predicted_n_glycosites": 2, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 2, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "2.4.1.143", "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.143", "type": "external" } ], "go_molecular_function": "GO:0008455 alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity;GO:0030145 manganese ion binding;GO:0042803 protein homodimerization activity", "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005795 Golgi stack", "go_biological_process": "GO:0006487 protein N-linked glycosylation;GO:0009312 oligosaccharide biosynthetic process", "synthesized_glycan_count": 8635, "hit_score": 0.1, "record_id": "E1BB36-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000010000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BBD8-1", "uniprot_id": [ { "id": "E1BBD8_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BBD8", "type": "external" } ], "mass": 94883.0, "length": 840, "protein_name": "Oxysterol-binding protein", "gene_name": "OSBPL7", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "OSBPL7", "gene_names_refseq": "", "protein_names_uniprotkb": "Oxysterol-binding protein", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (bta:508936); (R-BTA-192105)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0015485 cholesterol binding", "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0097038 perinuclear endoplasmic reticulum;GO:0005776 autophagosome", "go_biological_process": "GO:0006869 lipid transport;GO:0071397 cellular response to cholesterol;GO:1901800 positive regulation of proteasomal protein catabolic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BBD8-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BBL5-1", "uniprot_id": [ { "id": "E1BBL5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BBL5", "type": "external" } ], "mass": 34564.0, "length": 308, "protein_name": "Growth/differentiation factor 15", "gene_name": 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"GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0002686 negative regulation of leukocyte migration;GO:0040015 negative regulation of multicellular organism growth", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BBL5-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BBM6-1", "uniprot_id": [ { "id": "E1BBM6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BBM6", "type": "external" } ], "mass": 30612.0, "length": 286, "protein_name": "Ventral anterior homeobox 2", "gene_name": "VAX2", "organism": "Bovine", "refseq_name": "ventral anterior homeobox 2", "refseq_ac": [ { "id": "NP_001179242", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179242", "type": "external" } ], 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Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. 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activity", "go_cellular_component": "GO:0005634 nucleus;GO:0031391 Elg1 RFC-like complex", "go_biological_process": "GO:0008283 cell population proliferation;GO:0006974 DNA damage response;GO:0045740 positive regulation of DNA replication;GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0033260 nuclear DNA replication", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCE1-1", "record_type": "protein", "filter_code": "0000000.0000000.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCH5-1", "uniprot_id": [ { "id": "E1BCH5_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCH5", "type": "external" } ], "mass": 126200.0, "length": 1123, "protein_name": "non-specific serine/threonine protein kinase", "gene_name": "LATS1", "organism": "Bovine", "refseq_name": "serine/threonine-protein kinase LATS1", "refseq_ac": [ { "id": "NP_001179795", 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"https://www.rhea-db.org/rhea/?query=ec:2.7.11.25", "type": "external" }, { "id": "2.7.11.24", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24", "type": "external" }, { "id": "2.7.11.22", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22", "type": "external" }, { "id": "2.7.11.13", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13", "type": "external" }, { "id": "2.7.11.23", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23", "type": "external" }, { "id": "2.7.12.1", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1", "type": "external" }, { "id": "2.7.12.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2", "type": "external" }, { "id": "2.7.11.17", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17", "type": "external" }, { "id": "2.7.11.39", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39", "type": "external" }, { "id": "2.7.10.2", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2", "type": "external" }, { "id": "2.7.1.150", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150", "type": "external" }, { "id": "2.7.11.12", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12", "type": "external" }, { "id": "2.7.11.31", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31", "type": "external" }, { "id": "2.7.11.26", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26", "type": "external" }, { "id": "2.7.11.21", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21", "type": "external" }, { "id": "2.7.1.153", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153", "type": "external" }, { "id": "2.7.1.137", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137", "type": "external" }, { "id": "2.7.1.154", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154", "type": "external" }, { "id": "4.1.1.32", "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32", "type": "external" }, { "id": "2.7.11.38", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38", "type": "external" }, { "id": "2.7.11.11", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11", "type": "external" }, { "id": "3.1.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-", "type": "external" }, { "id": "2.7.4.6", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6", "type": "external" }, { "id": "2.7.13.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3", "type": "external" }, { "id": "2.7.4.18", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18", "type": "external" }, { "id": "3.1.24.-", "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-", "type": "external" }, { "id": "2.7.11.-", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-", "type": "external" }, { "id": "2.7.11.4", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4", "type": "external" }, { "id": "2.7.2.3", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3", "type": "external" }, { "id": "2.7.11.10", "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10", "type": "external" } ], "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0030331 nuclear estrogen receptor binding", "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome", "go_biological_process": "GO:0017015 regulation of transforming growth factor beta receptor signaling pathway;GO:0043065 positive regulation of apoptotic process;GO:0051301 cell division;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:1900181 negative regulation of protein localization to nucleus", "synthesized_glycan_count": 0, "hit_score": 0.2, "record_id": "E1BCH5-1", "record_type": "protein", "filter_code": "0000000.0000101.010000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCI6-1", "uniprot_id": [ { "id": "E1BCI6_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCI6", "type": "external" } ], "mass": 106779.0, "length": 971, "protein_name": "Reversion-inducing cysteine-rich protein with Kazal motifs", "gene_name": "RECK", "organism": "Bovine", "refseq_name": "reversion-inducing cysteine-rich protein with Kazal motifs precursor", "refseq_ac": [ { "id": "NP_001179394", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001179394", "type": "external" } ], "gene_names_uniprotkb": "RECK", "gene_names_refseq": "RECK", "protein_names_uniprotkb": "Reversion-inducing cysteine-rich protein with Kazal motifs", "protein_names_refseq": "reversion-inducing cysteine-rich protein with Kazal motifs precursor", "tax_id": 9913, "disease": "", "pathway": " (bta:517232); (R-BTA-163125)", "pathway_count": 2, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation. Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7. ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex. Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity. Also inhibits metalloproteinase activity of MMP2 and MMP14 (MT1-MMP)., [UniProtKB, UniProtKB]", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0015026 coreceptor activity;GO:0004866 endopeptidase inhibitor activity;GO:0017147 Wnt-protein binding;GO:0008191 metalloendopeptidase inhibitor activity", "go_cellular_component": "GO:0005886 plasma membrane;GO:1990909 Wnt signalosome;GO:0098552 side of membrane", "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0030336 negative regulation of cell migration;GO:0001955 blood vessel maturation;GO:0060070 canonical Wnt signaling pathway;GO:0060828 regulation of canonical Wnt signaling pathway", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCI6-1", "record_type": "protein", "filter_code": "0000000.0000001.010000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCL3-1", "uniprot_id": [ { "id": "E1BCL3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCL3", "type": "external" } ], "mass": 32246.0, "length": 290, "protein_name": "Nucleophosmin", "gene_name": "", "organism": "Bovine", "refseq_name": "", "refseq_ac": [], "gene_names_uniprotkb": "", "gene_names_refseq": "", "protein_names_uniprotkb": "Nucleophosmin", "protein_names_refseq": "", "tax_id": 9913, "disease": "", "pathway": " (R-BTA-3899300); (R-BTA-606279); (R-BTA-6804115); (R-BTA-8869496); (R-BTA-9833482)", "pathway_count": 5, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 1, "predicted_n_glycosites": 0, "predicted_o_glycosites": 1, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 1, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [], "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0042393 histone binding", "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:1990904 ribonucleoprotein complex", "go_biological_process": "GO:0010824 regulation of centrosome duplication;GO:0000055 ribosomal large subunit export from nucleus;GO:0006338 chromatin remodeling;GO:0042127 regulation of cell population proliferation;GO:0043066 negative regulation of apoptotic process", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCL3-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000001000.001.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCN4-1", "uniprot_id": [ { "id": "E1BCN4_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCN4", "type": "external" } ], "mass": 75715.0, "length": 678, "protein_name": "Long-chain-fatty-acid--CoA ligase ACSBG2", "gene_name": "ACSBG2", "organism": "Bovine", "refseq_name": "long-chain-fatty-acid--CoA ligase ACSBG2 isoform X2", "refseq_ac": [ { "id": "XP_024850729", "url": "https://www.ncbi.nlm.nih.gov/protein/XP_024850729", "type": "external" } ], "gene_names_uniprotkb": "ACSBG2", "gene_names_refseq": "ACSBG2", "protein_names_uniprotkb": "Long-chain-fatty-acid--CoA ligase ACSBG2; 6.2.1.15; 6.2.1.3; Acyl-CoA synthetase bubblegum family member 2; Arachidonate--CoA ligase ACSBG2", "protein_names_refseq": "long-chain-fatty-acid--CoA ligase ACSBG2 isoform X2", "tax_id": 9913, "disease": "", "pathway": " (bta:526688)", "pathway_count": 1, "publication_count": 0, "publication_id_list": "", "class_list": "", "function": "", "predicted_glycosites": 0, "predicted_n_glycosites": 0, "predicted_o_glycosites": 0, "predicted_c_glycosites": 0, "predicted_s_glycosites": 0, "mined_glycosites": 0, "mined_n_glycosites": 0, "mined_o_glycosites": 0, "mined_c_glycosites": 0, "mined_s_glycosites": 0, "reported_n_glycosites": 0, "reported_o_glycosites": 0, "reported_c_glycosites": 0, "reported_s_glycosites": 0, "reported_n_glycosites_with_glycan": 0, "reported_o_glycosites_with_glycan": 0, "reported_c_glycosites_with_glycan": 0, "reported_s_glycosites_with_glycan": 0, "total_reported_n_glycosites": 0, "total_reported_o_glycosites": 0, "total_reported_c_glycosites": 0, "total_reported_s_glycosites": 0, "total_n_glycosites": 0, "total_o_glycosites": 0, "total_c_glycosites": 0, "total_s_glycosites": 0, "reported_fully_resolved_glycans": 0, "reported_phosphosites": 0, "reported_mutagensis": 0, "reported_glycation": 0, "reported_snv": 0, "reported_interactions": 0, "missing_score": 10000, "biomarker_type": "", "glycan_count": 0, "disease_count": 0, "glyco_site_count": 0, "binding_glycan_count": 0, "secondary_ac_list": "", "ec_number_list": [ { "id": "6.2.1.3", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.3", "type": "external" }, { "id": "6.2.1.15", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.15", "type": "external" }, { "id": "6.2.1.-", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-", "type": "external" }, { "id": "6.2.1.76", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.76", "type": "external" }, { "id": "6.2.1.2", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.2", "type": "external" }, { "id": "6.2.1.25", "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.25", "type": "external" } ], "go_molecular_function": "GO:0005524 ATP binding;GO:0047617 fatty acyl-CoA hydrolase activity;GO:0047676 arachidonate-CoA ligase activity", "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol", "go_biological_process": "", "synthesized_glycan_count": 0, "hit_score": 0.1, "record_id": "E1BCN4-1", "record_type": "protein", "filter_code": "0000000.0000001.100000.010000000000000000.0000000000000.000.00000", "kg_view_protein": true }, { "uniprot_canonical_ac": "E1BCV3-1", "uniprot_id": [ { "id": "E1BCV3_BOVIN", "url": "https://www.uniprot.org/uniprot/E1BCV3", "type": "external" } ], "mass": 37928.0, "length": 326, "protein_name": "Ras association domain family member 2", "gene_name": "RASSF2", "organism": "Bovine", "refseq_name": "ras association domain-containing protein 2", "refseq_ac": [ { "id": "NP_001422055", "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001422055", "type": "external" } ], "gene_names_uniprotkb": "RASSF2", "gene_names_refseq": "RASSF2", "protein_names_uniprotkb": "Ras association domain family member 2", "protein_names_refseq": "Ras association (RalGDS/AF-6) domain family 2; 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